task
stringclasses
5 values
input
stringlengths
89
339
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCOC(=O)[C@H]1C=C(C#N)O[C@@H](c2ccc(C)cc2)C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N1CCOCC1)c1c(CNC(N2CCC(c3nc(C)no3)CC2)=O)cccc1 ### Response: Cc1noc(C2CCN(C(=O)NCc3ccccc3CN3CCOCC3)CC2)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1 Fragment 2: [1*]C(=O)C([8*])(C)C ### Response: COc1ccc(NC(=O)C(C)(C)c2cccc(F)c2)c(OC)c1OC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(OCCn2cc[nH+]c2)c(/C=C/C(=O)[O-])n1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a carboxyl group? CCC[NH2+][C@@H]([C@@H]1COCCO1)[C@H]1CCCc2cccnc21 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)N(CC(C)(C)O)C(=O)N[C@@H](c1cccc(C(F)(F)F)c1)C1CC1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN1CC(Oc2ccccc2)=NC(SCC(=O)Nc2cc(C)ccc2C)=N1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(CC)ccc1NC(=O)C(N1CCCC1)=O ### Response: CCc1ccc(NC(=O)C(=O)N2CCCC2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cc1ccccc1 Fragment 2: [16*]c1ccccc1 ### Response: Cn1cc(S(=O)(=O)N2CCC[C@@H]2Cc2ccccc2)cn1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]CC(=O)[O-] Fragment 2: [1*]C(C)=O ### Response: CC(=O)N1CCC[C@H](C(=O)N(CC(=O)[O-])CC(F)(F)F)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#CC1=C(N)OC2=C(C(=O)CCC2)[C@H]1c1cc([N+](=O)[O-])ccc1Cl ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1ccc(C(=O)NC[C@@H]2C[C@@H](O)C[NH+]2Cc2ccccc2)c(C)n1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ketone group? O=S1(=O)CCc2[nH]c3cc(F)c(F)c(F)c3c2C1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(C)C(=O)[C@H]1CC[C@H](CNC(=O)Nc2cccc(C#N)c2)O1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? O=C(N1CCN(CCc2ccccc2)CC1)C1(c2cc(-c3cccs3)on2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CC=CCC1 Fragment 2: [1*]C(=O)N[5*] ### Response: Cc1nc(CNC(=O)N[C@@H]2CC=CCC2)sc1C
functional_group
### Instruction: Does the molecule contain a sulfonyl group? Cc1ccc([C@@H](C)[NH2+][C@@H](C)CCC(=O)[O-])cc1F ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1ccccc1NC(=O)[C@H](C#N)Cc1cccnc1 ### Response: 0
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#C[C@@H](NC(=O)c1cn(Cc2cccnc2)nn1)c1cccc(Cl)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CC(C)(C)C)C(=O)c1ccc(CNC(=O)C2CCCC2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? COc1cc(NC(=O)c2ccccc2SCC#N)cc(OC)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [1*]C(=O)C[4*] ### Response: CCCNC(=O)C[NH+]1CC[C@]2(O)CCCC[C@@H]2[C@@H]1c1ccc(OC)cc1OC
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccc(cc1)OC)[C@H]([NH2+]CC1(CCOCC1)SC)C1CC1 ### Response: COc1ccc([C@H]([NH2+]CC2(SC)CCOCC2)C2CC2)cc1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1ccccc1NC(=S)N1CCN(c2ccc(F)cc2)CC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C)[NH+]1CCC(CCNC(=O)NCCc2c3c([nH]c2C)cccc3)CC1 ### Response: CC[NH+]1CCC(CCNC(=O)NCCc2c(C)[nH]c3ccccc23)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1C(=O)/C(=C2\Sc3ccc(OC)cc3N2C)SC1=S Fragment 2: [8*]CC=C ### Response: C=CCN1C(=O)/C(=C2\Sc3ccc(OC)cc3N2C)SC1=S
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nn2c(C)c(C(=O)NCc3ccccc3F)cnc2c1-c1ccc(F)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c(OC)cc1)[C@H](c1[nH+]ccn1C)Nc1ncc(Cl)cc1F ### Response: COc1ccccc1[C@@H](Nc1ncc(Cl)cc1F)c1[nH+]ccn1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(F)c(OC)c(F)c1 Fragment 2: [4*]Cc1ccccc1Cl ### Response: COc1c(F)cc(NC(=O)NCc2ccccc2Cl)cc1F
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1sc2nc(C)nc(N3CC[NH+](C[C@@H]4CCCO4)CC3)c2c1C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=[N+]([O-])c1cc2c(c(C[NH+]3CCN(c4ccc(F)cc4)CC3)c1)OCOC2 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. NC(=O)COC(=O)c1cc(-c2ccc(Cl)cc2)nn1-c1ccccc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(Cc1cc(ccc1F)F)C(=O)O[C@H](Cn1cccn1)C ### Response: C[C@@H](Cn1cccn1)OC(=O)CCc1cc(F)ccc1F
functional_group
### Instruction: Does the molecule contain a ether group? CO[C@H]1CCC[C@H]1n1c([C@@H](C)Cl)nc2cnccc21 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ketone group? COc1ccc(Nc2nc(NCCO)nc3c2cnn3C)cc1Cl ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CCCCC1 Fragment 2: [1*]C(=O)[C@@H]1CC(=O)N([10*])C1 ### Response: O=C1NC2(CCN(C(=O)[C@@H]3CC(=O)N(C4CCCCC4)C3)CC2)Nc2ccccc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)C[C@@H]1CCCCC[NH+]1CC1CC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCCn1c2c(c(=O)n(C)c1=O)[C@H](c1ccc(OC)cc1)[C@@H](NC(=O)c1ccccc1)C(=O)N2 ### Response: 4
functional_group
### Instruction: Does the molecule contain a nitrile group? CCC(CC)[NH+](Cc1cnn2c1NCCC2)CC(C)C ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NC(N1CCC(CC1)[NH+]1CCCC1)=O)CN(C1CC1)C(=O)OC(C)(C)C ### Response: CC(C)(C)OC(=O)N(CCNC(=O)N1CCC([NH+]2CCCC2)CC1)C1CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc2nccnc2cc1OC(=O)c1sccc1Br ### Response: O=C(Oc1ccc2nccnc2c1)c1sccc1Br
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC1(C)[C@@](C)(C(=O)[O-])[C@@]12CC[C@@H]2C(=O)NCc1ccco1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ester group? Cc1ccc(OCC(=O)Nc2nnc(-c3ccn(C(C)C)n3)o2)cc1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[NH+]1CCN(CC(=O)Nc2ccc(N3CCCCC3)cc2)CC1 ### Response: 3
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H](NC(=O)C1C(C)(C)C1(C)C)c1ccc(Br)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1c(c2c(ccc(OC)c2)cc1)/C=C1/NC(N(C1=O)Cc1ccc(cc1)Br)=O)C ### Response: COc1ccc2ccc(OC)c(/C=C3/NC(=O)N(Cc4ccc(Br)cc4)C3=O)c2c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN(CCCNS(=O)(=O)c1cn(C)cn1)c1ccccc1F ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](Nc1ccc(C(=O)[O-])cc1)C1CC[NH+](C)CC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(C(=O)NCc2nc3ccccc3n2CC(=O)N(c2ccccc2)C(C)C)cc1 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CSc1ccc(NC(=O)N2CCN(c3ncccc3C#N)CC2)cc1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c12c(sc(C(=O)N(c3cccc4ncccc34)C)c2)CCC1 ### Response: CN(C(=O)c1cc2c(s1)CCC2)c1cccc2ncccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C[NH+]1CCC(C(N)=O)CC1)(=O)Nc1ncc(Cc2c(cccc2)Cl)s1 ### Response: NC(=O)C1CC[NH+](CC(=O)Nc2ncc(Cc3ccccc3Cl)s2)CC1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. N#CC1=C(SCC(=O)Nc2cccc(Cl)c2)N=C([O-])[C@H](C#N)C12CCCCC2 ### Response: 3
functional_group
### Instruction: Does the molecule contain a nitro group? CNC(=O)[C@H]1CCCN(c2cc(C)c([N+](=O)[O-])cn2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [12*]S(=O)(=O)c1c(C)cc(C)cc1C Fragment 2: [16*]c1cccc(F)c1 ### Response: Cc1cc(C)c(S(=O)(=O)Nc2ncn(Cc3cccc(F)c3)n2)c(C)c1
functional_group
### Instruction: Does the molecule contain a halide group? CC1=C(C#N)[C@](NC(=O)c2cncc(Br)c2)(C(F)(F)F)C([O-])=N1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ester group? C[C@H](Oc1cccc(C#N)c1)C(=O)NC[C@]1(N2CCOCC2)CCSC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [nH]1c[nH+]c(CN2CCC(CC2)N(CC)S(=O)(C)=O)c1 ### Response: CCN(C1CCN(Cc2c[nH]c[nH+]2)CC1)S(C)(=O)=O
functional_group
### Instruction: Does the molecule contain a amine group? COCc1nc(CNc2cc(NC(C)=O)c(F)cc2F)cs1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cc(C)c(C(=O)N2CC[C@@H](NC(=O)OC(C)(C)C)[C@H](C)C2)c(=O)[nH]1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(NCc1ccccc1OCC1CC1)c1cc2cccnn2n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCCc1cccc(c1)Cl)C[C@H]1N(Cc2sccc2)CCNC1=O ### Response: O=C(C[C@@H]1C(=O)NCCN1Cc1cccs1)NCCc1cccc(Cl)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H](C)(c1ccncc1)N(C(=O)NCc1c(OC(C)(C)C)cccc1)C ### Response: C[C@H](c1ccncc1)N(C)C(=O)NCc1ccccc1OC(C)(C)C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CCc2sc(C(=O)N3CC[S@@](=O)C(C)(C)C3)cc2C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@H]1(N(S(=O)(c2c([C@@H]1O)cccc2)=O)C)Cc1c(C)nn(c1C)C ### Response: Cc1nn(C)c(C)c1C[C@@H]1[C@@H](O)c2ccccc2S(=O)(=O)N1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)(C)OC(=O)N1CCc2ncn(Cc3cc(F)c(F)c(F)c3)c(=O)c2C1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. O(c1cc2c(cc1)CCc1c(C(=O)N[C@@H](C(C)C)C)noc1-2)C ### Response: COc1ccc2c(c1)-c1onc(C(=O)N[C@H](C)C(C)C)c1CC2
functional_group
### Instruction: Does the molecule contain a amine group? CC[NH+]1CCC[C@@H]1CNC(=O)c1nc2nc(C)cc(C)n2n1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1nc(C(=O)N2CCc3sccc3[C@@H]2c2cccs2)nn1-c1ccc(F)cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(Nc1ccc(Oc2cnccn2)cc1)[C@@H]1C[C@@H]1c1ccc(F)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [3*]OC(C)C ### Response: CC(C)OC(=O)c1ccc(NC(=O)C[NH+]2CCn3cccc3[C@@H]2C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nc([O-])c2sc([14*])cc2n1 Fragment 2: [16*]c1ccccc1 ### Response: Cc1ccc(S(=O)(=O)Cc2nc([O-])c3sc(-c4ccccc4)cc3n2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(cc(c(cc1)F)NC(C1(CC1)c1ccc(Cl)cc1)=O)NC(C)=O ### Response: CC(=O)Nc1ccc(F)c(NC(=O)C2(c3ccc(Cl)cc3)CC2)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(NCc1ccc(cc1)F)[C@H](SCc1ncoc1C(C)C)C ### Response: CC(C)c1ocnc1CS[C@H](C)C(=O)NCc1ccc(F)cc1
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccc2ncc(C(=O)Nc3ncccc3OCc3ccncc3)n2c1 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1cccc(C(=O)N[C@H](C(=O)N2CCCC2)C2CCN(C(=O)CCc3ccccc3)CC2)c1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1CNC(=O)C[C@@H](NC(N)=O)c1cccs1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(Cl)c(cc(C(N(CC)CC)=O)c1)NC(=O)[C@@H]1[NH2+]CC=C1 ### Response: CCN(CC)C(=O)c1ccc(Cl)c(NC(=O)[C@H]2C=CC[NH2+]2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nn(CC(=O)N[C@@H]2CCCC[C@H]2C)c(=O)c2cc3sc(C)cc3n12 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [1*]C(=O)c1cc([14*])nc(SC)c1C#N ### Response: CSc1nc(C2CC2)cc(C(=O)NCC#Cc2ccccc2)c1C#N
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [16*]c1ccc(F)cc1F ### Response: O=c1[nH]c(CSc2nnc(-c3ccccc3)n2-c2ccc(F)cc2F)nc2ccccc12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1cc(NC(=O)CSc2nnnn2-c2ccccc2)ccc1Cl ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(C)nc2ncnn12 Fragment 2: [1*]C(C)=O ### Response: CC(=O)N(C)c1cccc(Nc2cc(C)nc3ncnn23)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [5*][NH2+][C@@H]([8*])C ### Response: CC(=O)Nc1cccc([C@@H](C)[NH2+]Cc2ccccn2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](CNC(=O)c1ccc(C(N)=S)cc1)Oc1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [8*]CC=C ### Response: C=CCn1c(SCC(=O)N2N=C(c3ccc(C)cc3)C[C@H]2c2ccco2)nc2ccccc2c1=O
functional_group
### Instruction: Does the molecule contain a amide group? CCOC(=O)c1c(NC(=O)CCc2ccc(C)o2)sc2c1CCCC2 ### Response: Yes
functional_group
### Instruction: Does the molecule contain a ketone group? CC(C)n1ncc2cc(NC(=O)c3c[nH]c4cc(Cl)ccc34)cnc21 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCC(=O)N1CCN(C(=O)NC[C@H]2CCC(C)(C)c3ccccc32)CC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a amine group? CC(C)C[C@H](C[NH3+])CN1CC[NH+](CC2CC2)CC1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCOC(=O)[C@H]1CCCN(C(=O)c2cn(CCc3ccccc3)nn2)C1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCCC Fragment 2: [16*]c1ccccc1[16*] ### Response: CCCNC(=O)CNC(=O)Nc1ccccc1SC1CCCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[S@@](=O)c1ccc(C[NH2+][C@H](c2cc3ccccc3o2)C2CC2)cc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1c([14*])nc2ccccc21 Fragment 2: [5*]NCc1ccc(OC)cc1 ### Response: COc1ccc(CNC(=O)[C@@H](C)n2c(C(F)(F)F)nc3ccccc32)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(/C([S-])=[NH+]/c2c(cc(C)cc2)C)nc2ccccc2c1 ### Response: Cc1ccc(/[NH+]=C(\[S-])c2ccc3ccccc3n2)c(C)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H]1CCCCN1C(=O)Nc1noc2c1COc1ccccc1-2 ### Response: 1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(/C=C/SCc1ccco1)N1CCc2[nH]ncc2C1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(sc(n1)C)C(C1=C([O-])C(N([C@H]1c1c(Cl)cccc1)CCC[NH+](C)C)=O)=O ### Response: Cc1nc(C)c(C(=O)C2=C([O-])C(=O)N(CCC[NH+](C)C)[C@H]2c2ccccc2Cl)s1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)c1ccc(N2C(=O)N=C(O)/C(=C/c3ccc(N(CC)CC)cc3)C2=O)cc1 ### Response: 4
functional_group
### Instruction: Does the molecule contain a nitrile group? N#Cc1cccnc1OCC[C@H]1CCC[NH2+]C1 ### Response: Yes