task
stringclasses
5 values
input
stringlengths
89
339
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [14*]c1nc2sc(C)c(C)c2c(=O)[nH]1 ### Response: Cc1ccc(-c2cnc(CCC(=O)O[C@H](C)c3nc4sc(C)c(C)c4c(=O)[nH]3)o2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nc(C2CC[NH+](Cc3ccc(CSC(F)F)o3)CC2)no1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc([C@@H]([C@H]2C[NH+]3CCN2CC3)O)cc1OC)OC ### Response: COc1cc(OC)cc([C@H](O)[C@H]2C[NH+]3CCN2CC3)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSC(=S)n1c2ccccc2c2ccccc21 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1nnc(cc1)-n1nccc1)(=O)Nc1ccccc1Cl ### Response: O=C(Nc1ccccc1Cl)c1ccc(-n2cccn2)nn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](NC(=O)[C@H]1C[C@@H]1c1ccco1)c1noc(-c2ccc(Cl)cc2)n1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(CSc1cn[nH]n1)Nc1ccc2c(c1)C(=O)c1ccccc1C2=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(S(=O)(=O)NCC[C@@H](O)c2ccccc2)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)[C@H](NC(=O)[C@@H]1CC(=O)N(Cc2ccco2)C1)c1cccs1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1ncnc1NC(=O)NCc1nc(-c2ccccc2)cs1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cc2ccccc2oc1=O Fragment 2: [3*]OCc1c(OC)cccc1OC ### Response: COc1cccc(OC)c1COC(=O)c1cc2ccccc2oc1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(N2C(=O)/C(SC2=S)=C/c2ccc(C(=O)OC)cc2)c1)F ### Response: COC(=O)c1ccc(/C=C2\SC(=S)N(c3ccc(F)cc3)C2=O)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(C1=C(C(=O)N(CCCN2CCOCC2)[C@@H]1c1sccc1)[O-])c1ccc(cc1)C ### Response: Cc1ccc(C(=O)C2=C([O-])C(=O)N(CCCN3CCOCC3)[C@@H]2c2cccs2)cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. Clc1ccc(cc1)COC1CN(C(=O)COc2ccc(OC)cc2)C1 ### Response: COc1ccc(OCC(=O)N2CC(OCc3ccc(Cl)cc3)C2)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C(C)(C)C(=O)OC Fragment 2: [5*]NS(=O)(=O)c1c(C)noc1C ### Response: COC(=O)C(C)(C)NS(=O)(=O)c1c(C)noc1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCC[C@@H](C)C(=O)N(C)[C@H](C)c1ccc(-n2cncn2)cc1 ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc2ncc(NC(=O)c3ccc(Cl)cc3)c(=O)n2c1 ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)[C@@H]1C=C[C@@H]([NH3+])C1)c1ccc(C(F)(F)F)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(C)ccc1-n1c(NCc2c(nccc2)OC2CCCC2)nnn1 ### Response: Cc1ccc(-n2nnnc2NCc2cccnc2OC2CCCC2)cc1
functional_group
### Instruction: Does the molecule contain a amide group? CC1CCN(C(=O)c2ccc(NCc3ccco3)nc2)CC1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccccc1Br)Nc1cc(Cl)ccc1-n1cncn1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC(C)(C)c1ccc(OC[C@H](C)C[NH3+])cc1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H]1CCCN(C(=O)NCC(C)(C)c2ccncc2)CC1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C([NH+]1C[C@@H](CCC1)c1nn(c(=O)n1CC)C)c1ccc(OC)c(C)c1C ### Response: CCn1c([C@@H]2CCC[NH+](Cc3ccc(OC)c(C)c3C)C2)nn(C)c1=O
functional_group
### Instruction: Does the molecule contain a hydroxyl group? O=C(CCNC(=O)[C@@H]1SCCc2ccccc21)NCc1cccnc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[C@@H](C)[C@@H](Cl)c1cc(C)c(F)cc1F ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](N2CC[S@](C(C)(C2)C)=O)C=CC1 ### Response: CC1(C)CN([C@H]2C=CCCC2)CC[S@]1=O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[NH+](C)Cc1cc(NC(=O)CCCC(=O)N2CCCCCC2)[nH]n1 ### Response: No
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC[NH+](Cc1ccccc1NC(C)=O)[C@@H]1CCN(c2ccccc2)C1=O ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cnc2c(C)cccn2c1=O Fragment 2: [3*]O[C@@H]([8*])CC ### Response: CC[C@@H](OC(=O)c1cnc2c(C)cccn2c1=O)c1cccc(OC)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H](O)[C@@H](C)Nc1ccc2sccc2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1nnn([9*])c1C Fragment 2: [1*]C(C)=O ### Response: CC(=O)Nc1ccc(NC(=O)c2nnn(-c3ccc(C)c(C)c3)c2C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [1*]C(=O)C[4*] ### Response: N#Cc1ccc(NCC(=O)N2CC[NH+](C3CC3)CC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)N(C)Cc1ccc(N(C)C)cc1)C(=O)N1CCCCC1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(-n2cc(CNC(=O)c3nc4nccc(C)n4n3)nn2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(nc(n1)NCCc1sc(N)nn1)C1CCCC1 ### Response: Nc1nnc(CCNc2nccc(C3CCCC3)n2)s1
functional_group
### Instruction: Does the molecule contain a nitrile group? Cc1nnc([S-])n1CC[NH3+] ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)c1nc(C)c2ccc(OC)cc2n1 Fragment 2: [14*]c1nc(C)c2ccc(OC)cc2n1 ### Response: COc1ccc2c(C)nc(N(C)CC[NH+]3CCCC[C@@H]3C)nc2c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CO[C@]1(C)C[C@@H](N(C)C(=O)CNC(=O)c2cc(C)oc2C)C1(C)C ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1nccn1-c1cc(N2CCC(C(=O)N3CCN(c4ccc(O)cc4)CC3)CC2)ncn1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCCNC(=O)N1C[C@@H](c2ccc(OC)cc2)[C@@H]2[C@H]1C1CC[NH+]2CC1 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSC[C@H](C)N(C)S(=O)(=O)N1CCc2ccccc2C1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1ccc(Cl)cc1NC(=O)[C@@H](C)n1ncc(-c2ccccc2)nc1=O ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCCNC(=O)CN1CCN(C(=O)Nc2ccncc2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCC(=O)NC2(CCCC2)C1=O Fragment 2: [8*]CN1CCC(=O)NC2(CCCC2)C1=O ### Response: CC1(C)C(CN2CCC(=O)NC3(CCCC3)C2=O)C1(C)C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1ccc(-n2nc(S[C@H](C)C(=O)Nc3ccccc3C)ccc2=O)cc1Cl ### Response: 0
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(NC(=O)NCCc2ccc(N(C)C)cc2)c(OC)c1 ### Response: 2
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@@H](CNC(=O)NC1CCCC1)c1ccccc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[NH+](CCCN(C1)Cc1cn2ccccc2c1C#N)Cc1ccccc1 ### Response: N#Cc1c(CN2CCC[NH+](Cc3ccccc3)CC2)cn2ccccc12
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)I)C(N1CC[C@@H]([C@H](C)C1)[NH3+])=O ### Response: C[C@@H]1CN(C(=O)c2ccc(I)cc2)CC[C@@H]1[NH3+]
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(NC(=O)c2c(nc(s2)C2CCCC2)C)cc2NC(COc2c1)=O ### Response: Cc1nc(C2CCCC2)sc1C(=O)Nc1ccc2c(c1)NC(=O)CO2
functional_group
### Instruction: Does the molecule contain a amide group? CSc1ncc(CNC(=O)CC2CC[NH+](C(C)C)CC2)n1C ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [11*]S[C@@H]1CCCc2ccccc21 Fragment 2: [14*]c1nnc([14*])n1N ### Response: COCCc1nnc(S[C@@H]2CCCc3ccccc32)n1N
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(Cc2nn3c(=O)/c(=C\c4ccccc4OC)sc3nc2=O)cc1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. COc1ccc(-c2nn(-c3ccccc3)cc2C(=O)OCCCl)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)/C=C/CBr ### Response: 4
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cn1cccc(C(=O)NCc2cc(-c3ccc4c(c3)OCCO4)on2)c1=O ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C#CCn1/c(=N/C(=O)CCOc2ccccc2)sc2cc(F)ccc21 ### Response: 3
functional_group
### Instruction: Does the molecule contain a carboxyl group? C[C@@H]1CN(C(=O)NC(=O)c2ccc(F)c(Cl)c2)C[C@@H](C)O1 ### Response: No
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(NCCc1nc2ccccc2[nH]1)N1CCN(c2ccccc2F)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aldehyde group? NC(=O)c1n[nH]c2ccc(NC(=O)c3cccc4cn[nH]c34)cc12 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(cc2OCOc12)N1C(C[C@@H](C1)C(NCc1c(OC)nccc1)=O)=O ### Response: COc1ncccc1CNC(=O)[C@H]1CC(=O)N(c2ccc3c(c2)OCO3)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C([C@H]1CN(C(=O)C2=CN3CCS(=O)(=O)N=C3C=C2)c2ccccc2O1)N1CCOCC1 ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1cc(C)n2nc(SCC(=O)N(C3CCC(C)CC3)C3CC3)nc2n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCN1CCO[C@@H](c2ccc(C)cc2C)C1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCc1cc(NC(=O)N[C@@H]2CCC[C@H](C(F)(F)F)C2)n(C)n1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O[C@@H](CN1CCN(c2cc(Cl)ncn2)CC1)c1ccc(Cl)cc1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [5*]NCc1ccccc1OC ### Response: COc1ccccc1CNC(=O)c1cn[nH]c1-c1cccs1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. c1ccc(OCC[NH+]2CCN(c3ccccc3)CC2)cc1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1cc([16*])c2ccccc2n1 Fragment 2: [7*]Cc1cc(C#N)n(C)c1C ### Response: Cc1c(/C=C/c2cc(C(=O)[O-])c3ccccc3n2)cc(C#N)n1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CCCCCC1=O Fragment 2: [16*]c1c(F)cc(C#C)cc1F ### Response: C#Cc1cc(F)c(NC(=O)NCCCN2CCCCCC2=O)c(F)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1 Fragment 2: [8*][C@@H](OC)C(=O)N/N=C(\C)c1ccc(O)cc1 ### Response: CO[C@@H](C(=O)N/N=C(\C)c1ccc(O)cc1)c1ccccc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1c(F)cc(NC(=O)C(=O)N[C@H](C)c2ccc3c(c2)CCCC3)cc1F ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C1/C(=C\c2ccc(Cl)cc2)S(=O)(=O)[C@@H](c2ccccc2)N1c1ccccc1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1oc2ccccc2c1C Fragment 2: [5*]N1CCO[C@]([13*])(C)C1 ### Response: Cc1c(C(=O)N2CCO[C@@](C)(C(N)=O)C2)oc2ccccc12
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)OC(=O)[C@H](C)CNC(=O)N1CCO[C@H](c2ccccc2Cl)C1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc([N+](=O)[O-])c1 Fragment 2: [6*]C(=O)NNc1ncnc2c1cnn2C ### Response: Cn1ncc2c(NNC(=O)c3cccc([N+](=O)[O-])c3)ncnc21
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H](C)N1C[C@H](C(=O)N2CCc3ccc([N+](=O)[O-])cc3C2)CC1=O ### Response: 5
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(N(CCc2ccccc2)C[C@@H](C(=O)OCC(=O)NC(=O)NC)C1)=O ### Response: CNC(=O)NC(=O)COC(=O)[C@H]1CC(=O)N(CCc2ccccc2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@](CN(C1)C(=O)C[C@@H](COC)C)(CC)C([O-])=O ### Response: CC[C@]1(C(=O)[O-])CCCN(C(=O)C[C@H](C)COC)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CSCc1ccc(NC(=O)c2cc(F)c(F)cc2[N+](=O)[O-])cc1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CCn1c(CC[NH3+])nnc1Sc1ncnc2ccc(F)cc12 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. o1c(C)c(cc1C)C[NH+]1CCC(CC1)CNC(C(Nc1c(OC)ccc(c1)C)=O)=O ### Response: COc1ccc(C)cc1NC(=O)C(=O)NCC1CC[NH+](Cc2cc(C)oc2C)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC1CCCCC1 Fragment 2: [3*]OCC ### Response: CCOc1cc(Br)ccc1C(=O)NC1CCCCC1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(CNC(=O)N(C)[C@@H](C)c2ccc(C)cc2)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1ccc(c(O)c1)O)CNc1n2ncnc2nc(C)c1C ### Response: Cc1nc2ncnn2c(NCCc2ccc(O)c(O)c2)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1csc(SCc2ccc(C(=O)N3CCN(C[C@@H]4CCCO4)CC3)cc2)n1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N(C)S(=O)(=O)c1cc([16*])c(F)c(F)c1 Fragment 2: [16*]c1cccc(C#C)c1 ### Response: C#Cc1cccc(N(C)S(=O)(=O)c2cc(F)c(F)c(C(=O)[O-])c2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? c1coc(C[NH2+]C2CCCC2)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(C)c(NC(=O)c2cc(Br)ccc2I)cc1OC ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOC(=O)c1c(-c2ccccc2)csc1NC(=O)c1ccncc1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a sulfonyl group? C[C@@H](Cn1cncn1)Nc1ccc2nnc(-c3ccccc3F)n2n1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [10*]N1CNc2ccccc2C1=O Fragment 2: [8*][C@H](C)C(=O)/N=c1/[nH]c2ccccc2s1 ### Response: C[C@H](C(=O)/N=c1/[nH]c2ccccc2s1)N1CNc2ccccc2C1=O
canonicalization
### Instruction: Canonicalize the following SMILES string. C([C@H]1CN(CCO1)Cc1ccccc1)(=O)NCCC(Nc1ccccc1)=O ### Response: O=C(CCNC(=O)[C@H]1CN(Cc2ccccc2)CCO1)Nc1ccccc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccccc1C#N Fragment 2: [5*]NCc1c(CC)nn(C)c1OC ### Response: CCc1nn(C)c(OC)c1CNC(=O)c1ccccc1C#N
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCc1n[nH]c(=S)n1CCNC(=O)c1cc(C)nc2c1c(=O)[nH]n2C ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccc(F)cc1NC(=O)c1ccnc(OC2CCC2)c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]Oc1ccc(Cl)cc1Cl Fragment 2: [5*]Nc1cc(C)ccc1OC ### Response: COc1ccc(C)cc1NC(=O)CNC(=O)COc1ccc(Cl)cc1Cl
functional_group
### Instruction: Does the molecule contain a ether group? O=C(Cc1cn2ccccc2n1)NCc1ccccc1Cn1ccnc1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CN1C(=O)C[C@H](NC(=O)[C@@]2(C)CC2(Cl)Cl)[C@H]1c1ccc(Cl)cc1 ### Response: 1