task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a ketone group? O=C(COc1ccc(Cl)c2cccnc12)NCCc1nnc2n1CCCCC2 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitro group? CCOCCOC(=O)Nc1c(C)cccc1CC ### Response: No
functional_group
### Instruction: Does the molecule contain a amine group? Cc1ccc(N2C(N)=[NH+]C[C@]23C[C@@H](C)CC(C)(C)C3)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH2+]C[C@H]1CCCCN1S(=O)(=O)N(C)CCS(C)(=O)=O ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(=O)c1ccc(-n2cncn2)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1n[nH]c([C@@H]2CN(C(=O)c3ccc4c(c3)nnn4C)CCO2)n1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]C(C)C Fragment 2: [3*]OC(C)C ### Response: COC(=O)[C@H]1C(=O)C2=C(C[C@@H]1C)Nc1ccccc1N[C@@H]2c1cccc(OC)c1OC(C)C
canonicalization
### Instruction: Canonicalize the following SMILES string. O=S(=O)(NC(C)(C)c1ccc(cc1)[N+]([O-])=O)c1cc(F)cc(c1)F ### Response: CC(C)(NS(=O)(=O)c1cc(F)cc(F)c1)c1ccc([N+](=O)[O-])cc1
canonicalization
### Instruction: Canonicalize the following SMILES string. O=C(N1CCN(CC(Nc2noc(C)c2)=O)CC1)C1(O)CCCC1 ### Response: Cc1cc(NC(=O)CN2CCN(C(=O)C3(O)CCCC3)CC2)no1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(NC(=O)N2CCN(c3ccc(F)cn3)CC2)s1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? Cc1ccc(NC(=O)[C@@H]2CCCCC[C@H]2[NH3+])c(C)c1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cncn1 Fragment 2: [1*]C(=O)C[NH+]([5*])C ### Response: COc1ccc(NC(=O)C[NH+](C)[C@H](C)c2ccc(-n3cncn3)cc2)cc1Cl
canonicalization
### Instruction: Canonicalize the following SMILES string. O(CC(F)(F)F)CCN1C([C@@](NC1=O)(c1ccc([N+]([O-])=O)cc1)C)=O ### Response: C[C@@]1(c2ccc([N+](=O)[O-])cc2)NC(=O)N(CCOCC(F)(F)F)C1=O
functional_group
### Instruction: Does the molecule contain a aldehyde group? Nc1nnc(SCC(=O)N2CC[NH+](C34CC5CC(CC(C5)C3)C4)CC2)s1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1cc(CNC(=O)c2cnc3c(cnn3C(C)C)c2)ccn1 ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cn1c(=O)[nH]c(=O)c2c1nc(N/N=C/c1ccc(Br)cc1)n2Cc1ccccc1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [1*]C(=O)c1cc(C)ccc1F ### Response: CCN(Cc1noc(C2CC2)n1)C(=O)c1cc(C)ccc1F
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [13*][C@H]1[C@H]([NH3+])CCCCN1CC ### Response: CCN1CCCC[C@@H]([NH3+])[C@@H]1c1cccc(C2CC2)c1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CC[NH2+][C@@H](c1ccc(Br)c2ccccc12)[C@H]1CCOC1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1C[C@@H](N(CC1)C(c1cnccc1)=O)c1nc(C)c(cn1)C(=O)N1CCOCC1 ### Response: Cc1nc([C@H]2CCCCN2C(=O)c2cccnc2)ncc1C(=O)N1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCC[C@H](C)NC(=O)[C@@H]1CCCN(Cn2c3c(sc2=O)CCCC3)C1 ### Response: 5
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*][C@@H](C)S(=O)(=O)c1ccc2c(c1)OCCCO2 Fragment 2: [16*]c1ccccc1 ### Response: C[C@H](c1ccccc1)S(=O)(=O)c1ccc2c(c1)OCCCO2
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)(NCc1ccccc1OCC1CC1)N[C@H]1C[C@@H]2O[C@H]1CC2 ### Response: O=C(NCc1ccccc1OCC1CC1)N[C@H]1C[C@H]2CC[C@@H]1O2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1 Fragment 2: [3*]Oc1cccc([16*])c1 ### Response: O=C(c1ccccc1F)N1CCS[C@@H]1c1cccc(OCc2ccccc2)c1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@H](NC(=O)C[C@H](O)c1ccccc1)c1ccc(S(C)(=O)=O)c(F)c1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC1(C)Cc2occc2[C@@H]([NH2+]Cc2ccc(COC3CCOCC3)cc2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(C)=O Fragment 2: [1*]C(=O)c1ccc(N[5*])cc1 ### Response: CC(=O)Nc1ccc(C(=O)OCC(=O)N[C@](C)(C#N)C2CC2)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=[N+]([O-])c1ccc(/C=C(\Cl)C=C2SC(=S)N=C2[O-])cc1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[NH+]1[C@H]2CC[C@@H]1CN(Cn1c(=S)n(C(F)F)c3ccccc31)CC2 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*]C1CC1 Fragment 2: [8*]C(C)(C)C ### Response: C[C@H]1CN(C(=O)c2cc(C3CC3)nn2C(C)(C)C)CC(C)(C)O1
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? C[C@H](CNC(=O)N(C)Cc1ccc(C(F)(F)F)cc1)c1ccsc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cncc(C2=N[C@H]([C@H]3CC(=O)N(Cc4cnccc4)C3)N=C2)c1 ### Response: O=C1C[C@H]([C@@H]2N=CC(c3cccnc3)=N2)CN1Cc1cccnc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C(=O)c1c(F)ccc(N)c1F)c1ccc(F)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(CN2CCN(CC2)C(=O)Nc2c(C[NH+](C)C3CCCCC3)cccc2)ccncc1 ### Response: C[NH+](Cc1ccccc1NC(=O)N1CCN(Cc2ccncc2)CC1)C1CCCCC1
functional_group
### Instruction: Does the molecule contain a thiol group? NC(=O)C1CCN(C(=O)c2cc(-c3ccc(F)cc3)[nH]n2)CC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CCCC Fragment 2: [1*]C(=O)C1CCCCC1 ### Response: CCCCC(=O)NC1CCN(C(=O)C2CCCCC2)CC1
functional_group
### Instruction: Does the molecule contain a nitro group? COc1cccc([C@@H](CNC(=O)C2=NN(c3ccccc3)C(=O)CC2)[NH+]2CCCC2)c1 ### Response: No
functional_group
### Instruction: Does the molecule contain a amide group? Cc1ccccc1-c1nn2c(=O)cc(N3CCN(C(=O)Nc4ccccc4F)CC3)nc2s1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@@]1(CCC)(CN(C(CNCC#C)=O)CC1)C(=O)[O-] ### Response: C#CCNCC(=O)N1CC[C@](CCC)(C(=O)[O-])C1
canonicalization
### Instruction: Canonicalize the following SMILES string. n1nc(n(c1COc1c(cccc1)Cl)C)SCC(c1c(cc(cc1)O)O)=O ### Response: Cn1c(COc2ccccc2Cl)nnc1SCC(=O)c1ccc(O)cc1O
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CN(C(=O)c1ccc(Cl)cc1Cl)c1cccc2ncccc12 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1c(C(=O)N2CC[C@@H](c3ccccc3)[C@H]2C)cnn1-c1ccncc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(-n2ccnc2)ccc(/C=C/C(Nc2ccc(C)c(NC(=O)C)c2)=O)c1 ### Response: CC(=O)Nc1cc(NC(=O)/C=C/c2ccc(-n3ccnc3)cc2)ccc1C
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [7*]Cc1ccc([14*])o1 Fragment 2: [7*]C1C(=O)N([10*])C(=O)C(C#N)=C1C ### Response: C=CCN1C(=O)C(C#N)=C(C)/C(=C/c2ccc(-c3ccc(Cl)c(C(=O)OC(C)C)c3)o2)C1=O
functional_group
### Instruction: Does the molecule contain a halide group? [NH3+][C@]1(C(=O)[O-])CCC[C@@H]1CCn1cc(I)cn1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(N(C(C)C)C(=O)[C@@H]1[C@@H](C)C1)C(Nc1ccccc1C(F)(F)F)=O ### Response: CC(C)N(CC(=O)Nc1ccccc1C(F)(F)F)C(=O)[C@H]1C[C@@H]1C
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(CC(Nc2ccncc2)=O)c(c1)OC ### Response: COc1ccccc1CC(=O)Nc1ccncc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)c1nn(CC(C)(C)O)c2c1CCCC2 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*][C@H]([8*])c1cccc(F)c1 Fragment 2: [4*][C@@H]([8*])c1ccccc1 ### Response: COc1ccc(C[NH2+][C@H](c2ccccc2)c2cccc(F)c2)cc1OC
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@@H]1CN(c2ccc([N+](=O)[O-])cc2S(N)(=O)=O)C[C@@H](C)O1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a ether group? CCOC(=O)[C@@H]1CCCC[C@H]1N1CCN(C(=O)[C@@H]2C[C@@H]2C)CC1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(C)nnc(NC(=O)Cn2ccc3c2cc(cc3)Br)s1 ### Response: Cc1nnc(NC(=O)Cn2ccc3ccc(Br)cc32)s1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(=O)c1cccc(OCc2c(C#N)cccc2)c1 ### Response: N#Cc1ccccc1COc1cccc(C=O)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C(COc1ncnc2ccc(Br)cc12)Nc1ccccc1Cl ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(NCC)nc(-c2n(CCC)ccn2)cc(C)n1 ### Response: CCCn1ccnc1-c1cc(C)nc(NCC)n1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(=O)Nc1ccc(S(=O)(=O)NCCC(=O)N[C@@H]2CCCc3ccccc32)cc1 ### Response: 0
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1C(=O)NCC(=O)N1C[C@@H]1CN(C)CCO1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. Cc1cnc2nc(C[C@H](O)C(F)(F)F)[nH]c2c1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NCC1(O)CCCCC1 Fragment 2: [1*]C(=O)[C@@H]([8*])C ### Response: Cc1ccc2c(c1)C(=O)N([C@@H](C)C(=O)NCC1(O)CCCCC1)C2=O
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cc(OC)c(OC)cc1C Fragment 2: [1*]C(=O)c1cc(C)no1 ### Response: COc1cc(C)c(NC(=O)c2cc(C)no2)cc1OC
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]C(C)(C)C Fragment 2: [4*][C@@H]([8*])C1CC1 ### Response: Cc1csc([C@H](NC(=O)N[C@H](C)c2nc(C(C)(C)C)no2)C2CC2)n1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Fc1cc(C[NH2+]CCCn2cc[nH+]c2)cc(F)c1F ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. O=C1NCCc2ccc(S(=O)(=O)N3CCC[C@@H](c4ncc[nH]4)C3)cc21 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)C[4*] Fragment 2: [5*]Nc1cccc(N[5*])c1 ### Response: C[C@H]1CCC[NH+](CC(=O)Nc2cccc(NC(=O)c3ccccc3)c2)C1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCC1C[NH+]([C@@H](Cc2c[nH]c3ccccc23)C(=O)[O-])C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(C[NH+]1CCCC[C@@H]1CN1CCOCC1)NCCC1=CCCCC1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. C[C@H]1CCC[C@H](C1)CNC(C(=O)Nc1c(=O)n(ccc1C)C)=O ### Response: Cc1ccn(C)c(=O)c1NC(=O)C(=O)NC[C@@H]1CCC[C@H](C)C1
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1[nH]nc(C(=O)N2CCC[C@@H](C[NH+]3CCN(c4ccccn4)CC3)C2)c1[N+](=O)[O-] ### Response: No
functional_group
### Instruction: Does the molecule contain a aldehyde group? Cc1cc(OC(=O)[C@@H](C)Sc2nncn2C)cc(C(C)C)c1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccncc1 Fragment 2: [12*]S(=O)(=O)c1ccc(F)cc1 ### Response: O=S(=O)(Nc1ccncc1)c1ccc(F)cc1
functional_group
### Instruction: Does the molecule contain a ketone group? CCOc1cc(C)ccc1NC(=O)C(=O)NCc1cccc(Cl)c1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. [C@H]1(CC(=O)N(C)C21CCN(c1cccc(C(=O)N(C)C)n1)CC2)C(=O)[O-] ### Response: CN(C)C(=O)c1cccc(N2CCC3(CC2)[C@H](C(=O)[O-])CC(=O)N3C)n1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@@H]1CCO[C@]2(CCOC2)C1 Fragment 2: [16*]c1cccc(F)c1 ### Response: C[C@@](O)(c1cccc(F)c1)[C@@H]1CCO[C@]2(CCOC2)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(C[C@@H]1CCOC1)C(=O)NC[C@@H](c1ccccc1)[NH+]1CCCC1 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? C[C@@H](CNC(=O)N(C)CCOc1ccc(F)cc1)c1ccsc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(COc1ccc(Br)cc1)NC(=S)Nc1ccc(Cl)cc1C(=O)[O-] ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1cccc(F)c1[16*] Fragment 2: [6*]C(=O)OC ### Response: COC(=O)c1c(F)cccc1NC(=O)[C@@H]1Cc2cc(C)c(C)cc2O1
functional_group
### Instruction: Does the molecule contain a amide group? Cn1ncc2c1CCc1sc(NC(=O)C3CC3)nc1-2 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1c2c(sc1N1CCC(C(=O)NC(C)C)CC1)c(=O)n(cn2)CC(=O)N[C@@H]1CCc2c1cccc2 ### Response: CC(C)NC(=O)C1CCN(c2nc3ncn(CC(=O)N[C@@H]4CCc5ccccc54)c(=O)c3s2)CC1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]Nc1ccc(N[5*])cc1 Fragment 2: [8*]CC1CC1 ### Response: C[C@H](Nc1ccc(NC(=O)[C@H]2CC(=O)N(CC3CC3)C2)cc1)c1ccccc1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1ccc([C@@H]2CCCC[C@@H](C)C2=O)s1 ### Response: No
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CSc1ccccc1NC(=O)[C@@H](C)Oc1cccc(C=O)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(-c2nnn(CC(=O)N[C@H]3CCCn4c(C)nnc43)n2)cc1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? C[C@@H](OC(=O)c1cccnc1SC(F)F)C(=O)NC1CC1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a ether group? COCc1ccc(C(=O)N2C[C@H](c3ccc(OC)cc3)C[C@H]2C)cc1 ### Response: Yes
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cc1ccc(S(C)(=O)=O)cc1C(=O)Nc1cnn(C(C)(C)C)c1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NC[C@H]1CCCO1 Fragment 2: [12*]S(C)(=O)=O ### Response: CS(=O)(=O)Nc1ccccc1C(=O)NC[C@H]1CCCO1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CN(Cc1ccsc1)C(=O)c1cccnc1Cl ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1cccc(F)c1 Fragment 2: [16*]c1ccccc1OC ### Response: COc1ccccc1CC(=O)/N=C1/S[C@@H]2CS(=O)(=O)C[C@@H]2N1c1cccc(F)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1noc(C)c1COc1ccc(C(=O)N2CC[NH+](Cc3nc(-c4ccsc4)no3)CC2)cc1 ### Response: 3
canonicalization
### Instruction: Canonicalize the following SMILES string. C1[C@@H](C(=O)OCC)CCC[NH+]1Cc1c(cccc1)C#N ### Response: CCOC(=O)[C@H]1CCC[NH+](Cc2ccccc2C#N)C1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C=CCN1CCN(C(=O)[C@@H](C)Oc2ccccc2C(C)C)CC1 ### Response: 2
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N([5*])CC[8*] Fragment 2: [5*]N([5*])CC1CC[NH+](C)CC1 ### Response: COc1ccc(CCN(CC2CC[NH+](C)CC2)C(=O)c2scnc2C)cc1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1cccs1 Fragment 2: [11*]Sc1nnc([14*])o1 ### Response: Fc1ccc(Oc2ccnc(Sc3nnc(-c4cccs4)o3)n2)cc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? CCOCCCNc1nnnn1-c1ccccc1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [4*]Cc1ccccc1[16*] Fragment 2: [4*]CC=C ### Response: C=CCOc1ccccc1C[NH+]1CCC[C@@H]1CN1CCOCC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? [NH3+][C@@H](Cc1csc([C@@H]2CSCCS2)n1)c1ccccc1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1CN(CCCCNC(=O)c2ccccc2-c2cncnc2)C[C@H](C)O1 ### Response: 0
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(ccc(c1)N1CCOCC1)NC(=O)c1cc(-c2ccccn2)nc2ccccc12 ### Response: O=C(Nc1ccc(N2CCOCC2)cc1)c1cc(-c2ccccn2)nc2ccccc12
functional_group
### Instruction: Does the molecule contain a amide group? Cc1nc(COC(=O)[C@@H]2CSCN2C(=O)CC(C)(C)C)sc1C ### Response: Yes