task
stringclasses
5 values
input
stringlengths
89
339
functional_group
### Instruction: Does the molecule contain a ester group? CC(C)C[C@@H](C(=O)N[C@H]1CC(=O)N(C2CC2)C1)N1CCCCC1=O ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc([C@@H]2c3c(C(N2c2nc(C)ccc2)=O)oc2c(c3=O)cc(cc2)C)cc(c1OCC)OC ### Response: CCOc1ccc([C@@H]2c3c(oc4ccc(C)cc4c3=O)C(=O)N2c2cccc(C)n2)cc1OC
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCN(CC1CC[NH2+]CC1)S(=O)(=O)c1cn(CC)cn1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a ether group? COCc1nc(C)cc(Sc2cccs2)n1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCS(=O)(=O)c1ccc(C(=O)N(Cc2ccccn2)c2nc3cc(C)cc(C)c3s2)cc1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1ccc(CNC(=O)CS(=O)(=O)c2scc(C)n2)c(C)c1 ### Response: Cc1csc(S(=O)(=O)CC(=O)NCc2ccccc2C)n1
functional_group
### Instruction: Does the molecule contain a ether group? CC[NH+]1CCC[C@H](NC(=O)c2ccc(OC)c(O)c2)C1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. n1cnc(-n2ccnc2)cc1N1CCC(C(Nc2nocc2)=O)CC1 ### Response: O=C(Nc1ccon1)C1CCN(c2cc(-n3ccnc3)ncn2)CC1
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@H](Sc1ccc(N)cc1Cl)C(=O)NC1CC1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCn1nccc1CNC(=O)Cn1cc2c(n1)c(C)nn2C(C)C ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]NS(=O)(=O)c1ccc(C)cc1C Fragment 2: [4*]Cc1ccc(C)cc1 ### Response: Cc1ccc(CNS(=O)(=O)c2ccc(C)cc2C)cc1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(=O)Nc1c(C)cc(NC(=O)[C@H]2[C@@H](C=C(C)C)C2(C)C)cc1C ### Response: 3
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](Oc1ccc(F)cc1)C(=O)Nc1nc2c(s1)CCCC2 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c2c(cc3CCCc31)occ2CC(OCC(=O)c1c(ccc(c1)C)C)=O ### Response: Cc1ccc(C)c(C(=O)COC(=O)Cc2coc3cc4c(cc23)CCC4)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccc(N[5*])cc1O Fragment 2: [1*]C(=O)c1cnoc1C ### Response: CC[C@@H](C)NC(=O)c1ccc(NC(=O)c2cnoc2C)cc1O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. O=C(Nc1ccc(F)cc1)C(=O)N1C[C@H]2CCCC[C@H]2C1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(c1ccccn1)N1CCC([NH+]2CCC[C@H](C(=O)N3CCOCC3)C2)CC1 ### Response: 1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[NH+](CC(=O)Nc1cccc(S(N)(=O)=O)c1)Cc1ccc(F)c(F)c1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? FC(F)(F)c1ccnc(NCc2cn3ccsc3n2)n1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1N(C(CC1)=O)c1cc(OCC(Nc2c(C)c(C)ccc2)=O)ccc1 ### Response: Cc1cccc(NC(=O)COc2cccc(N3CCCC3=O)c2)c1C
ring_counting
### Instruction: Count the five-membered rings in the following molecule. N#Cc1ccc(Cl)cc1NCc1ccc([N+](=O)[O-])c(F)c1 ### Response: 0
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@@H]([13*])C1 Fragment 2: [5*]N1CCO[C@@H](C[8*])C1 ### Response: c1cnn(C[C@H]2CN(CCCOc3ccc4c(c3)OCO4)CCO2)c1
functional_group
### Instruction: Does the molecule contain a ketone group? C[C@@H]1OCC[C@@H]1C(=O)NC[C@@H](c1ccc(Cl)cc1)N1CCOCC1 ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCO[C@H]([13*])C1 Fragment 2: [6*]C(N)=O ### Response: Cc1cc2c(N3CCO[C@H](C(N)=O)C3)ncnc2s1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1(N([C@H]2C[C@H](CC)CCC2)[C@H](C)C(N2[C@@H]1CCCC2)=O)=O ### Response: CC[C@@H]1CCC[C@@H](N2C(=O)[C@H]3CCCCN3C(=O)[C@H]2C)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(c1ccc(c(C)c1)F)N/C(NCC1([O-])CCC1)=[NH+]/CC ### Response: CC/[NH+]=C(/NCc1ccc(F)c(C)c1)NCC1([O-])CCC1
functional_group
### Instruction: Does the molecule contain a halide group? Cc1cc(F)ccc1CCNc1ccc(Cl)cc1[N+](=O)[O-] ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [15*][C@H]1CCOC2(CCCCC2)C1 Fragment 2: [8*]C[C@@H]([8*])[NH3+] ### Response: [NH3+][C@@H](Cc1cccnc1)[C@H]1CCOC2(CCCCC2)C1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1ccco1 Fragment 2: [1*]C(=O)c1cc(C)n([9*])c1C ### Response: Cc1cccc(-n2c(C)cc(C(=O)N[C@H](CO)c3ccco3)c2C)c1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1cccc([16*])c1 Fragment 2: [14*]c1ccc(C)nn1 ### Response: Cc1ccc(-n2nccc2NC(=O)c2cccc(-c3ccoc3)c2)nn1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCN(CCC#N)Cc1nc(N)nc(Nc2ccc(F)cc2)n1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? CC(C)[C@H](NC(=O)[C@@H]1CC2=c3ccccc3=[NH+][C@@H]2[C@H]2c3ccccc3C(=O)N21)C(=O)NC1CCCC1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [9*]n1cnc2sc(C)c(C)c2c1=O Fragment 2: [1*]C(=O)C[8*] ### Response: Cc1sc2ncn(CC(=O)N[C@@H](c3ccccc3)C(C)C)c(=O)c2c1C
ring_counting
### Instruction: Count the six-membered rings in the following molecule. C[C@H](NC(=O)Cc1ccccc1)[P@@H](=O)[O-] ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]OCC Fragment 2: [15*][C@@]1(O)CS[C@H](C)C1 ### Response: CCOC(=O)C(F)(F)[C@@]1(O)CS[C@H](C)C1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC[C@@H](C)[C@H](C)n1c(CCl)nc2cc(Br)cnc21 ### Response: 5
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? O=C(N[C@H](c1ccccc1F)C1CCCC1)N1CCC(CO)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? CCCNS(=O)(=O)c1ccc(NC(=O)C2CCCCC2)cc1 ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCc1c(C[NH2+]C)cnn1-c1cccc(Br)c1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a sulfonyl group? O=S(=O)([N-]c1ccc([C@H]2C=c3ccccc3=[NH+]2)cc1)c1ccccc1Cl ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1c(CN2CCCC3(C2)OCCO3)nc2c(F)cccc21 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(Oc2ccccc2)cc(c1)/C=N\n1nnnc1N ### Response: Nc1nnnn1/N=C\c1cccc(Oc2ccccc2)c1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@@H]1OCC[C@H]1C(=O)N1CCCC[C@@H]1CN1CCOCC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccn([9*])n1 Fragment 2: [16*]c1ccccc1Cl ### Response: CC(C)c1nc(C2(NC(=O)c3ccn(-c4ccccc4Cl)n3)CCCC2)no1
functional_group
### Instruction: Does the molecule contain a ether group? Cc1cc(=O)oc2cc(OCC(=O)OCc3nc4ccccc4s3)ccc12 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. C(NNC([C@H](CC)Oc1ccccc1)=O)(c1ccc(cc1)OC)=O ### Response: CC[C@H](Oc1ccccc1)C(=O)NNC(=O)c1ccc(OC)cc1
functional_group
### Instruction: Does the molecule contain a amine group? CC1=C(C(=O)Nc2ccccc2C)[C@H](c2ccccc2C(F)(F)F)NC(=O)N1 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. S1(=O)(=O)C[C@@H](CC1)n1c2c(c(C)n1)[C@@H](C1CCCCC1)SCC(=N2)O ### Response: Cc1nn([C@@H]2CCS(=O)(=O)C2)c2c1[C@@H](C1CCCCC1)SCC(O)=N2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCn1ncc(C[NH2+]C)c1C1CC1 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [3*]O[C@@H]1CCOC2(CCOCC2)C1 Fragment 2: [16*]c1cccc(CBr)c1 ### Response: BrCc1cccc(O[C@@H]2CCOC3(CCOCC3)C2)c1
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)(C)c1ccc(S(=O)(=O)Nc2cccc(-c3c[nH+]c4n3CCC4)c2)cc1 ### Response: 2
canonicalization
### Instruction: Canonicalize the following SMILES string. Cc1c(Cl)c(n([C@H]2C[C@@](CCC2)(NC)C#N)n1)C ### Response: CN[C@]1(C#N)CCC[C@@H](n2nc(C)c(Cl)c2C)C1
functional_group
### Instruction: Does the molecule contain a carboxyl group? Cc1cc(NC(=O)COc2ccccc2C=O)ccc1N1CC[NH+](C)CC1 ### Response: No
functional_group
### Instruction: Does the molecule contain a nitrile group? C#CCNC(=O)CSc1nc2sc(C)c(C)c2c(=O)n1CCCC ### Response: No
functional_group
### Instruction: Does the molecule contain a halide group? CCn1c(=O)c(=O)[nH]c2cc(C(=O)Nc3ccc(C(C)C)cc3)ccc21 ### Response: No
canonicalization
### Instruction: Canonicalize the following SMILES string. C1CO[C@@H](C(Nc2ccc(cc2)NC(c2cn(C)c3c2cccc3)=O)=O)C1 ### Response: Cn1cc(C(=O)Nc2ccc(NC(=O)[C@H]3CCCO3)cc2)c2ccccc21
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)[C@@H]1CCC(=O)N(C)[C@H]1[13*] Fragment 2: [5*]NCCCOC ### Response: COCCCNC(=O)[C@@H]1CCC(=O)N(C)[C@H]1c1cccc(F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1OC2(C[C@H](SC(=[NH2+])N)C1)CCOCC2 ### Response: NC(=[NH2+])S[C@@H]1CCOC2(CCOCC2)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2c(CC1)ccc(C(CCC(N[C@@H]1C[C@@H](CC1)[NH+](C)C)=O)=O)c2 ### Response: C[NH+](C)[C@@H]1CC[C@H](NC(=O)CCC(=O)c2ccc3c(c2)CCC3)C1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1c(cc(OC)cc1)-c1cc2n(c(nc2c(C(N2CCC(CC2)C)=O)n1)C)[C@@H]1CCS(=O)(=O)C1 ### Response: COc1cccc(-c2cc3c(nc(C)n3[C@@H]3CCS(=O)(=O)C3)c(C(=O)N3CCC(C)CC3)n2)c1
functional_group
### Instruction: Does the molecule contain a thiol group? CCOC(=O)C1=C(C)N(CCc2cccs2)C(=O)N[C@H]1c1cccc(C#N)c1 ### Response: No
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCc1nn(C)cc1C[NH2+]Cc1ccc(NC(=O)C(C)C)cc1 ### Response: 3
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? N#Cc1ccc(Oc2cccc(NC(=O)[C@@H](O)c3ccccc3)c2)nc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1(ccnc(c1)OC(C)(C)C)CNC(=O)NC[C@@]1(O)c2ccccc2CC1 ### Response: CC(C)(C)Oc1cc(CNC(=O)NC[C@]2(O)CCc3ccccc32)ccn1
functional_group
### Instruction: Does the molecule contain a amide group? CC(C)c1ccc([C@@H]2[C@@H](C(N)=O)[C@@H](C)Nc3ncnn32)cc1 ### Response: Yes
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(c2c(c(C([O-])=O)cc([nH]2)=O)c1)C ### Response: Cc1cccc2c(C(=O)[O-])cc(=O)[nH]c12
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COCCN(Cc1cccnc1)C(=O)CC1(O)CCCCC1 ### Response: 2
ring_counting
### Instruction: Count the five-membered rings in the following molecule. C[C@H]1CN[C@H](c2cccc(C3CC3)c2)S1 ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. C(C(=O)Nc1c(Cl)cc(c(n1)C)Cl)OC(c1cc2c(CC[C@@H](C)C2)s1)=O ### Response: Cc1nc(NC(=O)COC(=O)c2cc3c(s2)CC[C@@H](C)C3)c(Cl)cc1Cl
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COc1ccccc1N1CCN(S(=O)(=O)c2ccc(Cl)c(C)c2Cl)CC1 ### Response: 1
functional_group
### Instruction: Does the molecule contain a amine group? Cc1cccc(C(=O)N2CCN(c3cnn(-c4ccccc4)c(=O)c3Cl)CC2)c1-n1cccc1 ### Response: No
functional_group
### Instruction: Does the molecule contain a hydroxyl group? C=CCSC1=NC(=O)[C@H]2C(=N1)NC(=O)C[C@@H]2C(=O)Nc1cc(F)ccc1F ### Response: No
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)c1ccccc1[16*] Fragment 2: [5*]N1CCN([5*])CC1 ### Response: CCSc1ccccc1C(=O)N1CCN(c2nc3c(S(C)(=O)=O)cccc3s2)CC1
canonicalization
### Instruction: Canonicalize the following SMILES string. O1[C@H](COCC1)C(N(CC(=O)N(C)C)C)=O ### Response: CN(C)C(=O)CN(C)C(=O)[C@H]1COCCO1
canonicalization
### Instruction: Canonicalize the following SMILES string. [O-]/C(=N\c1scnn1)C[NH+](CCC(C)C)C1CC1 ### Response: CC(C)CC[NH+](C/C([O-])=N/c1nncs1)C1CC1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCCOc1cc(N2CCN(C(=O)C(C)C)CC2)nc(C)n1 ### Response: 3
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CCOc1cc(C(F)(F)F)nc(CN)n1 ### Response: 2
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC(=O)[C@@H]1CCN(C(=O)c2cnn(CCC(C)C)c2C)c2ccccc21 ### Response: 4
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? Cn1c(SCC(=O)N2CCN(Cc3c(F)cccc3Cl)CC2)nnc1C(F)(F)F ### Response: 2
functional_group
### Instruction: Does the molecule contain a aromatic_ring group? O=C(c1ccc2c(c1)OCCO2)N1CCO[C@H](Cc2ccccc2)C1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [8*]Cn1c(C)c2c(=O)n([9*])[nH]c2cc1=O Fragment 2: [16*]c1ccccc1C ### Response: Cc1ccccc1-n1[nH]c2cc(=O)n(Cc3ccccc3)c(C)c2c1=O
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CCCC(=O)Nc1c2c(nn1-c1cccc(C)c1C)CSC2 ### Response: 2
functional_group
### Instruction: Does the molecule contain a halide group? C[C@H](c1ccc(F)cc1)N1Cc2cc(NC(=O)COc3ccccc3)ccc2OCC1=O ### Response: Yes
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COC(=O)[C@@H](c1ccc(C#N)cc1)N(C)Cc1nnc(C2CC2)n1C ### Response: 1
canonicalization
### Instruction: Canonicalize the following SMILES string. c1cc(ccc1OC)NC(/C(C#N)=C(\[C@@H]1[C@@H](C1)OCC)[O-])=O ### Response: CCO[C@@H]1C[C@@H]1/C([O-])=C(/C#N)C(=O)Nc1ccc(OC)cc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. COc1ccc(CCCC(=O)Nc2cccc(S(N)(=O)=O)c2)cc1F ### Response: 0
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC[C@H](C)[C@H](NC(=O)c1ccc([N+](=O)[O-])cc1)C(N)=O ### Response: 1
functional_group
### Instruction: Does the molecule contain a amide group? C[C@@H]1CC(C(=O)Nc2ccc(-n3cncn3)c(Cl)c2)C[C@@H](C)O1 ### Response: Yes
ring_counting
### Instruction: Count the six-membered rings in the following molecule. CC(C)OC(=O)C1=C(N)Oc2c(c(=O)oc3ccccc23)[C@]12C(=O)Nc1ccc(Br)cc12 ### Response: 4
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [1*]C(=O)CC[8*] Fragment 2: [5*]N1CCC([15*])CC1 ### Response: CO[C@@H](CNC(=O)CCC1CCN(C(C)=O)CC1)c1ccc(F)cc1
functional_group
### Instruction: Does the molecule contain a hydroxyl group? Cc1ccc([C@](O)(CC(=O)NNC(=O)c2oc3ccccc3c2C)C(F)(F)F)o1 ### Response: Yes
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [5*]N1CCc2sccc2[C@@H]1C Fragment 2: [4*]CC1=NC(=O)C2=C(c3ccccc3)CSC2=N1 ### Response: C[C@H]1c2ccsc2CCN1CC1=NC(=O)C2=C(c3ccccc3)CSC2=N1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [14*]c1nncn1CC Fragment 2: [1*]C(=O)c1cc(Br)ccc1F ### Response: CCn1cnnc1-c1cccc(NC(=O)c2cc(Br)ccc2F)c1
canonicalization
### Instruction: Canonicalize the following SMILES string. C1c2c(CC1)nc1c(c2C(N2CCN(c3cccc(c3C)C)CC2)=O)cccc1 ### Response: Cc1cccc(N2CCN(C(=O)c3c4c(nc5ccccc35)CCC4)CC2)c1C
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? COC1CC[NH+](CCNC(=O)NCC(C)(C)c2ccncc2)CC1 ### Response: 3
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1c(C)[nH]c2ccccc12 Fragment 2: [1*]C(=O)C[8*] ### Response: Cc1[nH]c2ccccc2c1CC(=O)N[C@H](C(N)=O)c1ccccc1
ring_counting
### Instruction: Count the five-membered rings in the following molecule. Cc1csc2[nH+]c(CN(C)[C@H](C)C(C)(C)C)cc(=O)n12 ### Response: 1
fragment_assembly
### Instruction: Assemble these two molecular fragments into a single molecule. Fragment 1: [16*]c1ccccc1F Fragment 2: [7*]Cc1c(C)n(C[8*])c2ccccc12 ### Response: Cc1c(/C=C/c2cccc[n+]2C)c2ccccc2n1Cc1ccccc1F
ring_counting
### Instruction: Count the five-membered rings in the following molecule. CC(C)n1nccc1NC(=O)NC[C@@H](O)c1ccc(Cl)c(F)c1 ### Response: 1
chain_length
### Instruction: What is the length of the longest acyclic carbon chain in the molecule? CC(C)Cn1nnnc1SCC(=O)Nc1ccc(F)c([N+](=O)[O-])c1 ### Response: 3