id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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530cefaaad0bf1360c000004 | Is bapineuzumab effective for treatment of patients with Alzheimer's disease? | Thus far, results from two large phase 3 trial programs with bapineuzumab and solaneuzumab, respectively, have brought rather disappointing results. More recently, in phase III studies, bapineuzumab has been discontinued because it did not prove clinically effective (despite its significant effect on biomarkers), while... | no |
55031963e9bde6963400002a | Is desmin an intermediate filament protein involved in Dilated Cardiomyopathy (DCM)? | Desmin-related myofibrillar myopathy (DRM) is a cardiac and skeletal muscle disease caused by mutations in the desmin (DES) gene. Mutations in the central 2B domain of DES cause skeletal muscle disease that typically precedes cardiac involvement. However, the prevalence of DES mutations in dilated cardiomyopathy (DCM) ... | yes |
530cefaaad0bf1360c000008 | Is lambrolizumab effective for treatment of patients with melanoma ? | However, through parallel efforts that have showcased the efficacy of small-molecule BRAF and MAP-ERK kinase (MEK) inhibitors, as well as the immune checkpoint inhibitors, namely ipilimumab and the anti-PD1/PDL1 antibodies (lambrolizumab, nivolumab, MPDL3280), an opportunity exists to transform the treatment of melanom... | yes |
532361fd9b2d7acc7e000013 | Is cadasil syndrome a hereditary disease? | CADASIL is the most frequent hereditary small-vessel disease of the brain. The clinical impact of various MR imaging markers has been repeatedly studied in this disorder, but alterations of contrast between gray matter and normal-appearing white matter remain unknown. The aim of this study was to evaluate the contrast ... | yes |
56c048e2ef6e39474100001d | Is nintedanib effective for Idiopathic Pulmonary Fibrosis? | In this review, we present the positive results of recently published clinical trials regarding therapy for IPF, with emphasis on pirfenidone and nintedanib. Nintedanib: evidence for its therapeutic potential in idiopathic pulmonary fibrosis In the Phase II TOMORROW trial, treatment with 150 mg of nintedanib twice dai... | yes |
530cefaaad0bf1360c000010 | Is pesticide exposure associated with polyneuropathy? | As the syndrome occurred after the acute cholinergic syndrome but before organophosphate-induced delayed polyneuropathy, the syndrome was called 'intermediate syndrome'. The characteristic features of the IMS are weakness of the muscles of respiration (diaphragm, intercostal muscles and accessory muscles including neck... | yes |
530f685c329f5fcf1e000002 | Is there an association between borna virus and brain tumor? | Borna disease virus (BDV), a nonsegmented, negative-strand RNA virus, infects a wide variety of mammalian species and readily establishes a long-lasting, persistent infection in brain cells. To investigate the biological characteristics of field isolates of Borna disease virus (BDV), as well as to understand BDV infec... | no |
56e05a7b51531f7e3300000d | Does PU.1 (SPI1) affect NF-kB binding? | Recent data demonstrate that developmental transcription factors like the macrophage fate-determining Pu.1 set the stage for the activity of ubiquitous transcription factors activated by inflammatory stimuli, like NF-kB, AP-1, and interferon regulatory factors (IRFs). Within 1217 bp of upstream sequence, 3 sites for NF... | yes |
55423fc0ed966d112c000001 | Does the majority of the mitochondrial genomes abide to the second parity rule (PR2)? | a large number of mitochondrial genomes significantly deviate from the 2nd parity rule in contrast to the eubacterial ones mitochondria may be divided into three distinct sub-groups according to their overall deviation from the aforementioned parity rule. The behaviour of the large majority of the mitochondrial genomes... | no |
530cefaaad0bf1360c00000f | Is there an association between bruxism and reflux? | Sleep bruxism is prevalent in GERD patients, and GERD is highly associated with SB. There was a statistical trend towards tooth wear progression being associated with gastric risk factors (p < 0.05). This article presents a case report of a 27-year-old male smoker with tooth wear and dentin sensitivity caused by GERD ... | yes |
514a59c2d24251bc0500005d | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | To evaluate the cost effectiveness of the four medications with a US FDA-approved indication for PMDD: fluoxetine, sertraline, paroxetine and drospirenone plus ethinyl estradiol (DRSP/EE). All SSRIs (fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram, and clomipramine) were effective in reducing premenstrual s... | yes |
53124e84e3eabad02100000c | Is endostatin a proangiogenic factor? | endostatin (antiangiogenic factor antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin human endostatin (rh-endostatin), a potential antiangiogenic agent, antiangiogenic PF4 and endostatin Angiostatin and endostatin are endogenous inhibitors of angiogenesis with anticancer effects the antiangi... | no |
554763f0f35db75526000002 | Can botulism poisoning of a pregnant woman harm her fetus? | Two botulism outbreaks were attributed to commercial ready-to-eat meat products and 3 to foods served in restaurants; several cases were attributed to non-Native home-prepared foods. Three affected pregnant women delivered healthy infants. Botulinum toxin is not expected to be present in systemic circulation following ... | no |
5709152ecf1c325851000014 | Does a linker histone exist in the yeast genome? | Hho1p is a bona fide linker histone In Saccharomyces cerevisiae, HHO1 encodes a putative linker histone with very significant homology to histone H1 HHO1p may play a similar role to linker histones, but at restricted locations in the chromatin The putative linker histone in Saccharomyces cerevisiae, Hho1p, has two regi... | yes |
51763a278ed59a060a000030 | Can protein coding exons originate from ALU sequences? | The Alu element has been a major source of new exons during primate evolution. Thousands of human genes contain spliced exons derived from Alu elements. More than 25% of Alu exons analyzed by RNA-Seq have estimated transcript inclusion levels of at least 50% in the human cerebellum, indicating widespread establishment ... | yes |
56c1d85cef6e394741000034 | Is there evidence that tomato juice lowers cholesterol levels? | The hypocholesterolemic effect of tomato juice has been investigated in an intervention study with rats, along with the possible inhibition effect of bioactive tomato compounds binding to the HMGCR enzyme. The molecular modelling showed that components of tomato can bind to the active site of the enzyme and compete wit... | yes |
56c44ce83aaba2a675000001 | Are there transposon-free regions in mammalian genomes? | Transposon-free regions in mammalian genomes. Despite the presence of over 3 million transposons separated on average by approximately 500 bp, the human and mouse genomes each contain almost 1000 transposon-free regions (TFRs) over 10 kb in length. The majority of human TFRs correlate with orthologous TFRs in the mouse... | yes |
56d2ee61f22319765a000007 | Are messenger RNA molecules epigenetically methylated? | The most abundant mRNA post-transcriptional modification is N(6)-methyladenosine (m(6)A), which has broad roles in RNA biology. N(6)-methyladenosine (m6A) is the most abundant modified base in eukaryotic mRNA and has been linked to diverse effects on mRNA fate. Recently, methylation patterns have also been revealed in... | yes |
5316d4fcb166e2b806000005 | Is invasion and metastasis one of the hallmarks of cancer? | The pathogenesis of MM involves the accumulation of extensive cytogenetic changes, as well as cancer-related phenotypic alterations that facilitate tumor cell survival, invasion and metastasis. This review presents current knowledge regarding the biological characteristics of this disease that are linked to the so-call... | yes |
54cf48acf693c3b16b00000b | Is progesterone effective for treatment of patients with traumatic brain injury based on clinical trial data? | BACKGROUND: Progesterone has been associated with robust positive effects in animal models of traumatic brain injury (TBI) and with clinical benefits in two phase 2 randomized, controlled trials. The proportion of patients with a favorable outcome on the Glasgow Outcome Scale (good recovery or moderate disability) was... | no |
5545e926d355485447000002 | Is there a role for the cylindromatosis tumor suppressor (CYLD) in lung cancer? | Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells increased expression of CYLD directly blocks TRAIL-induced NF-κB activation, and consequently increases TRAIL-induced apoptosis in lung cancer cells. CYLD may act as a therapeutic target of lung can... | yes |
55435aeced966d112c000007 | Can we detect DNA strand asymmetries using dinucleotide relative abundance "genomic signatures"? | comparing the heterogeneities of bacterial genomes with respect to strand-independent first- and second-order features, (i) G + C content and (ii) dinucleotide relative abundance, the concept of a genomic signature was introduced with the observation of species-type specific Dinucleotide Relative Abundance Profiles (DR... | no |
5344194daeec6fbd07000006 | Is there any relationship between histone ubiquitylation and splicing? | histone H2B-specific deubiquitinase and demonstrate that H2B deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. H2B monoubiquitylation (H2BK123ub1) marks introns in Saccharomyces cerevisiae H2B ubiquitination by facilitating splicing pre-mRNA splicing plays a critica... | yes |
56cc947b5795f9a73e000033 | Can SUMO affect calcium homeostasis? | Increasing SUMOylation levels correlated inversely with calcium influx in sensory neurons. CRMP2 deSUMOylation by SUMO proteases SENP1 and SENP2 normalized calcium influx to those in the CRMP2AAA mutant. Thus, our results identify a novel role for SUMO modification in CRMP2/CaV2.2 signaling pathway Moreover, SUMO1 over... | yes |
52b2ecd34003448f55000003 | Have mutations in the GARS gene been identified to cause Charcot-Marie-Tooth Disease Type 2D (CMT2D)? | Charcot-Marie-Tooth disease type 2D is a hereditary axonal and glycyl-tRNA synthetase (GARS)-associated neuropathy that is caused by a mutation in GARS. Mutations in the GARS gene cause Charcot-Marie-Tooth 2D and distal spinal muscular atrophy type V - allelic disorders characterized by predominantly distal upper extr... | yes |
515df6f2298dcd4e5100002d | Does melanoma occur in people of African origin ? | ALM is the most common type of melanoma amongst Asians, Africans, ALM develops on palmar, plantar, and subungual skin, and its biology is different from that of other cutaneous melanomas, where sunlight is the major known environmental determinant We present four albinos with histologic diagnoses of skin cancer Four Ni... | yes |
551ae6c564b14b4618000001 | Are people with blood group O protected against severe Malaria? | Differential carbonylation of cytoskeletal proteins in blood group O erythrocytes: potential role in protection against severe malaria. . Our findings indicate a possible correlation between the protection against severe malaria in blood group O individuals and a specific pattern of 4-HNE-carbonylation of cytoskeleton ... | yes |
532aad53d6d3ac6a34000010 | Is there a crystal structure of the full-length of the flaviviridae NS5(Methyltransferase - RNA depended RNA Polymerase) ? | flavivirus NS5 harbors a methyltransferase (MTase) in its N-terminal ≈ 265 residues and an RNA-dependent RNA polymerase (RdRP) within the C-terminal part. One of the major interests and challenges in NS5 is to understand the interplay between RdRP and MTase as a unique natural fusion protein in viral genome replication... | yes |
56cf32e23975bb303a000006 | Can venlafaxine block NET and SERT? | Treatment for 14 days with 70 mg/kg per day venlafaxine, which inhibits both the NET and SERT, or 10 mg/kg per day phenelzine, a monoamine oxidase inhibitor, produced antidepressant-like effects on behavior without altering NET or SERT expression. Venlafaxine blocks both serotonin and norepinephrine transporters (SERT ... | yes |
572211540fd6f91b68000016 | Can vitamin B1 deficiency cause encephalopathy? | Wernicke's encephalopathy (WE) is a severe neurological syndrome caused by thiamine (vitamin B1) deficiency and clinically characterized by the sudden onset of mental status changes, ocular abnormalities, and ataxia Wernicke encephalopathy (or Wernicke-Korsakoff encephalopathy) is a rarely diagnosed neurological disord... | yes |
54f7291630767eb92e000002 | Are epigenetic modifications implicated in cardiovascular development and disease? | Gene expression regulation through the interplay of DNA methylation and histone modifications is well-established, although the knowledge about the function of epigenetic signatures in cardiovascular disease is still largely unexplored. The study of epigenetic markers is, therefore, a very promising frontier of science... | yes |
550895c12e93f0133a000002 | Can exosomes be detected in urine? | Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes is a fingerprint of the releasing cell type and of its status. For this reason, and because they are released in easily accessible body fluids such as blood and ... | yes |
56f7c44109dd18d46b000013 | Is Kanzaki disease associated with deficiency in alpha-N-acetylgalactosaminidase? | Kanzaki disease (OMIM#104170) is attributable to a deficiency in alpha-N-acetylgalactosaminidase (alpha-NAGA; E.C.3.2.1.49), which hydrolyzes GalNAcalpha1-O-Ser/Thr. Our findings suggest that the association of alpha-NAGA with its substrates is strongly affected by the amino acid substitution at R329 and that the ass... | yes |
5710a650cf1c32585100002b | Is Mycobacterium avium less susceptible to antibiotics than Mycobacterium tuberculosis? | The prevalence of MAC lung infection in two inner city hospitals was four times higher than that of TB. Most patients with combined infection were clinically consistent with MTB and responded to anti MTB treatment alone. The triplex PCR developed by us could be used to detect and differentiate M. tuberculosis, M. avium... | yes |
5544bcde5beec11c10000003 | Are there conserved noncoding elements identified between genomes of human and teleosts? | We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their developmental regulatory target genes, and phylogenetically and functio... | yes |
514b335dd24251bc05000061 | Does cortical spreading depression appear in ischemic penumbra following ischemic stroke? | During the subacute phase, the irreversible damage expands into the penumbra: multiple electrical and biological signals are triggered by periinfarct, spreading depression-like depolarizations leading to hypoxia and stepwise increase in lactate. Experimental and clinical studies indicate that waves of cortical spreadin... | yes |
5501b3b3e9bde69634000007 | Is phospholamban a regulatory/inhibitory protein of the Ca ATPase SERCA? | The membrane protein complex between the sarcoplasmic reticulum Ca(2+)-ATPase (SERCA) and phospholamban (PLN) controls Ca(2+) transport in cardiomyocytes, thereby modulating cardiac contractility. β-Adrenergic-stimulated phosphorylation of PLN at Ser-16 enhances SERCA activity via an unknown mechanism. Phospholamban (P... | yes |
5718a69e7de986d80d00000a | Is Alpers disease inherited in an autosomal recessive mode? | Alpers-Huttenlocher syndrome (AHS) is a very rare autosomal recessive disorder Alpers syndrome is an autosomal recessive mitochondrial DNA depletion disorder that affects children and young adults Alpers' syndrome is a fatal neurogenetic disorder first described more than 70 years ago. It is an autosomal recessive, dev... | yes |
56c02bc3ef6e394741000018 | Is vemurafenib effective for hairy-cell leukemia? | CONCLUSIONS: A short oral course of vemurafenib was highly effective in patients with relapsed or refractory hairy-cell leukemia. Our results strongly support and inform the clinical use of BRAF and MEK inhibitors in HCL. The therapeutic approach of vemurafenib in treatment-refractory hairy cell leukemia is promising a... | yes |
56c095b7ef6e394741000025 | Is there an association between TERT promoter mutation and survival of glioma patients? | Mutations lead to TERT upregulation and are associated with aggressive clinical behavior in glioblastomas. Kaplan-Meier's survival analysis showed that TERT promoter mutation (P=0.037), Isocitrate dehydrogenase (IDH) mutation (P<0.001), and 1p/19q codeletion (P<0.001) were associated with favorable overall survival (OS... | yes |
56cf27293975bb303a000003 | Does ziconotide bind to N-type calcium channels? | Since this region partially overlaps with residues previously implicated in block of the channel by omega-conotoxin GVIA, we assessed the effects of mutations in the putative EF hand domain on channel block by omega-conotoxin GVIA and the structurally related omega-conotoxin MVIIA. Both of the toxins irreversibly block... | yes |
52f77f892059c6d71c00002c | Is stop codon bypass possible? | In 1999, proof-of-concept for treating these disorders was obtained in a mouse model of muscular dystrophy, when administration of aminoglycosides restored protein translation by inducing the ribosome to bypass a PTC. Aminoglycosides can bypass nonsense mutations and are the prototypic agents for translational bypass t... | yes |
56e5b445edfc094c1f000001 | Is the protein β1-integrin recycled? | Pathways selectively regulating β1-integrin recycling are implicated in cancer invasion and metastasis, integrin-positive early and recycling endosomes LPA-induced recycling of β1 integrin, RCP-mediated recycling of α5β1 integrin CycD1 overexpression increased β1 integrin recycling inhibition of autophagy slowed dow... | yes |
55032179e9bde6963400002e | Are BBS mutations involved in syndromic Hirschsprung disease? | Epistasis between RET and BBS mutations modulates enteric innervation and causes syndromic Hirschsprung disease Here, we report 3 families with BBS and HSCR with concomitant mutations in BBS genes and regulatory RET elements, whose functionality is tested in physiologically relevant assays. Our data suggest that BBS mu... | yes |
5311ceeae3eabad021000008 | Is there any software for automated analysis of immuno-histochemistry images? | The LIM homeobox gene Lhx2 is expressed in cortical progenitors during development and also in the superficial layers of the neocortex in maturity. However, analysis of Lhx2 function at later stages of cortical development has been hampered by severe phenotypes associated with early loss of function. The vein graft sa... | yes |
56f555b609dd18d46b000007 | Is TALEN being used on stem cells? | Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Genetic correction of patient-derived induced pluripotent stem cells (iPSCs) by TALENs or CRISPR-Cas9 holds promise for DMD gene therapy; however, the safety of such nuclease treatme... | yes |
52f8a7eb2059c6d71c000052 | Is there an association between bruxism and reflux | Rhythmic masticatory muscle activity, including sleep bruxism (SB), can be induced in healthy individuals by experimental esophageal acidification, which plays an important role in the pathogenesis of gastroesophageal reflux disease (GERD). However, no robust evidence supports the association between SB and GERD. Sleep... | yes |
53443b13aeec6fbd0700000e | Can a peptide aptamer be used as protein inhibitor? | Peptide aptamers of LIM-only protein 2 (Lmo2) were previously used to successfully treat Lmo2-induced tumours in a mouse model of leukaemia. Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity. Accumulating work over the past decade has shown tha... | yes |
56e83a2342442bac75000001 | Are integrins part of the extracellular matrix? | Several constituents of the ECM provide adhesive cues, which serve as binding sites for cell trans-membrane receptors, such as integrins. We also determined that blocking β1integrins, the major class of receptors for all ECM proteins tested, Here, we elucidate a cross-scale mechanism for tissue assembly and ECM remodel... | yes |
54c26e29f693c3b16b000003 | Is Calcium homeostasis important in cardiac physiology and pathophysiology? | Maintenance of cellular calcium homeostasis is critical to regulating mitochondrial ATP production and cardiac contraction. the Ca(2+) signal regulates the most important activities of the cell, from the expression of genes, to heart and muscle contraction and other motility processes, to diverse metabolic pathways in... | yes |
55152c2946478f2f2c000005 | Is the gene DUX4 epigenetically regulated in somatic cells? | There are several genes on chromosome 4q35 region including DUX4 within D4Z4 repeats. Transcription of these genes is usually repressed by epigenetic modifications of this chromosomal region and also accumulation of transcriptional repressors to the repeat array. Recent studies provide compelling evidence that a retrot... | yes |
56f553aa09dd18d46b000005 | Have hESC been tested for the treatment of age-related macular degeneration? | Development of human embryonic stem cell therapies for age-related macular degeneration In this review, we describe recent approaches to develop cell-based therapies for the treatment of AMD. Recent research has focused on replacing the retinal pigment epithelium (RPE), a monolayer of cells vital to photoreceptor cell ... | yes |
554614bcd355485447000004 | Does d-tubocurarine (d-TC) induces irreversible inhibition of nicotinic acetylcholine receptor (nAChR) at the neuromuscular junction? | An integrated model describing the interaction of nondepolarizing neuromuscular blocking agents with reversible anticholinesterase agents is derived and compared with a naive model using experimental data obtained from four anesthetized dogs. Three consecutive but separate steady-state d-tubocurarine blocks (approximat... | no |
54f4b319d0d681a040000005 | Is zyxin a focal adhesion protein? | zyxin from FAs zyxin relocation from focal adhesions . Here we systematically examined the expression, localization, and function of zyxin, a focal adhesion protein focal adhesion protein zyxin Focal adhesions formed in the absence of α-actinins are delayed in their maturation, exhibit altered morphology, have decreas... | yes |
5162e9df298dcd4e5100004b | Could DNA (cytosine-5-)-methyltransferases serve as tumour markers? | Here, we report evidence of the overexpression of DNA methyltransferases 3B (DNMT3B) in invasive cervical cancer and of the inhibition of metastasis by DNMT3B interference. This study was designed to determine the significance of DNA methyltransferases (DNMTs) in DNA hypermethylation in esophageal squamous cell carcino... | yes |
54da0c524b1fd0d33c00000b | Is phospholamban phosphorylated by Protein kinase A? | cAMP-dependent protein kinase (PKA) phosphorylation of PLB phosphorylation of PLN, at either Ser(16) by PKA Activation of cardiac muscle sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) by beta1-agonists involves cAMP- and PKA-dependent phosphorylation of phospholamban (PLB), which relieves the inhibitory effects of PLB o... | yes |
54ff106b6ad7dcbc1200000c | Are there telemedicine applications for chronic pain management? | An integrated cognitive-behavioral and physical therapy group protocol has been developed and then implemented at remote sites using videoconferencing technology to provide pain management for veterans. Tele-pain management: use of videoconferencing technology in the delivery of an integrated cognitive-behavioral and ... | yes |
513efe01bee46bd34c00000e | Is paramyxovirus involved in human subacute thyroiditis? | Most cases of subacute thyroiditis are caused by a variety of viruses, for example, Coxsackie, cytomegalovirus, Epstein-Barr virus, and adenovirus. Influenza immunization or infection may cause subacute thyroiditis. Coxsackie virus has been reported to be one of the viruses associated with the disease. The etiology of ... | no |
56ae67a40a360a5e4500000c | Is there any link between the aurora B kinase and the polycomb protein ring1B? | The aurora B kinase and the polycomb protein ring1B combine to regulate active promoters in quiescent lymphocytes. We show that the Aurora B kinase and the polycomb protein Ring1B have essential roles in regulating transcriptionally active genes in quiescent lymphocytes. Ring1B and Aurora B bind to a wide range of acti... | yes |
55376b37bc4f83e82800000b | Is CD99 encoded by MIC2 gene? | We report 2 unusual cytogenetic findings in a pediatric Ewing sarcoma, an insertion of the MIC2 gene encoding CD99 from Xp to 10p and a submicroscopic deletion of the well-known tumor supressor gene KLF6 We obtained the final diagnosis of ES/PNET by immunohistochemical molecular study with positive staining for the MIC... | yes |
550e6688a103b7801600000d | Has the fungus Ashbya gossypii got many nuclei that share cytoplasm? | multinucleated Ashbya gossypii cells. multinucleated Ashbya gossypii fungal cells Nuclei in the filamentous, multinucleated fungus Ashbya gossypii divide asynchronously. multinucleated Ashbya gossypii cells We analyzed a unique asynchronous nuclear division cycle in a multinucleated filamentous fungus, Ashbya gossypii... | yes |
513f4249bee46bd34c000012 | Is microRNA(miRNA) 30 involved in post-ischemic cardiac remodeling? | The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosi Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an attrac... | yes |
530e131b5937551c09000002 | Is statin use associated with improved outcomes after aneurysmal subarachnoid hemorrhage? | Statins have been shown in two recent small phase I/II trials to be associated with a marked reduction in clinical and transcranial Doppler (TCD) evidence of vasospasm after aneurysmal subarachnoid haemorrhage (SAH). Statins did not result in reduced TCD velocities, clinical or angiographic vasospasm, or improvements ... | yes |
52cae04c03868f1b06000024 | Does molindone affect body weight? | Mean weight increased by 0.54 kg, and mean body mass index by 0.24 kg/m(2). A large-scale trial comparing a first-generation antipsychotic (molindone) with newer agents did not find significant differences in treatment response, although the newer antipsychotics were associated with more severe weight gain. No agent ... | yes |
5717fb557de986d80d000009 | Is the SDHAF2 gene encoding a protein necessary for flavination of SDHA? | the gene encoding the enzyme responsible for the flavination of SDHA (SDHAF2 or hSDH5) SDHAF2, required for flavination of SDHA Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in SDHAF2, required for flavination of SDHA. At... | yes |
516523fd298dcd4e51000055 | Could Arimidex (anastrozole) cause hot flashes? | More than a third of breast cancer patients undergoing aromatase inhibitor (AI) treatment report joint pain. In the first 6 weeks, emergence of joint pain was associated with increase in general pain, fatigue, disturbed sleep, hot flashes, vaginal dryness, and decreased sexual activity. Antiestrogen therapy can cause v... | yes |
54dcd8f61388e8454a000001 | Are Alu elements transcribed? | Alu RNAs in the human transcriptome Alu elements can be transcribed in two different ways, by two independent polymerases 'Free Alu RNAs' are transcribed by Pol III from their own promoter 'embedded Alu RNAs' are transcribed by Pol II as part of protein- and non-protein-coding RNAs Recent studies have demonstrated that... | yes |
5171833c8ed59a060a00000f | Are chromomethylases present in animal genomes? | Many plant, animal, and fungal genomes contain cytosine DNA methylation in asymmetric sequence contexts (CpHpH, H = A, T, C). However, at the SUPERMAN locus, asymmetric methylation was only completely abolished in drm1 drm2 chromomethylase 3 (cmt3) triple mutant plants. Although neither the drm1 drm2 double mutants nor... | no |
5321bb019b2d7acc7e00000b | Is low T3 syndrome related with high BNP in cardiac patients? | BNP and fT3 are independently associated with exercise capacity in severely compromised HF patients. fter adjustment for known confounders, NT-pro-BNP was significantly associated with fT3 and low-T3 syndrome. fT3 (HR 0.58, 95%CI 0.34-0.98) and low-T3 syndrome (HR 3.0, 95%CI 1.4-6.3) were predictive for mortality after... | yes |
52b2e97df828ad283c000012 | Has overexpression of sirtuins been reported to increase lifespan in budding yeast (Saccharomyces cerevisiae)? | In addition, Sir2 overexpression prevents Rif1 deletion from disrupting Sir2 at IGS1 and shortening lifespan. Roles for sirtuin proteins at telomeres are thought to promote lifespan in yeast and mammals. Overexpression of sirtuins (NAD(+)-dependent protein deacetylases) has been reported to increase lifespan in buddin... | yes |
531a31a1b166e2b806000035 | Is TREM2 associated with Alzheimer's disease? | Absence of TREM2 polymorphisms in patients with Alzheimer's disease and Frontotemporal Lobar Degeneration These data demonstrate that TREM2 coding region is highly conserved, implying a crucial role of this receptor. Further studies, including a functional analysis, are certainly required to clarify the role of TREM2 ... | yes |
5505ad7ff73303d458000007 | Does the protein mTOR regulate autophagy? | autophagy is negatively regulated by the mammalian target of rapamycin receptor (mTOR) Subjecting cells to starvation or rapamycin efficiently induces autophagy by inhibiting the MTOR signaling pathway triggering increased autophagic flux. Several pathways, including mTOR, have been shown to regulate autophagy. these ... | yes |
532f05bdd6d3ac6a34000026 | Has proteomics been used in the study of Pick's disease? | In Pick's disease, increased AGE, CML, CEL, HNE and MDAL bands of about 50 kDa were observed in the frontal cortex (but not in the occipital cortex) in association with increased density of glial acidic protein bands. Thus, brain and cerebrospinal fluid (CSF) samples from patients with Alzheimer's disease, Down syndrom... | yes |
52cb9b9b03868f1b0600002d | Are there any urine biomarkers for bladder cancer diagnosis? | CONCLUSIONS: Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer Novel promising markers are in va... | yes |
533d0f44c45e13371400000e | Is signal transducer and activator of transcription-3 (STAT3) critical for tumor angiogenesis progression? | (STAT3) is critical for cancer progression by regulating tumor cell survival, proliferation, and angiogenesis. Herein, we investigated the regulation of STAT3 activation and the therapeutic effects of Icaritin, a prenyl flavonoid derivative from Epimedium Genus, in renal cell carcinoma (RCC). Overall, these results s... | yes |
56cca4da5795f9a73e000034 | Is sumoylation implicated in myogenesis? | Sentrin/small ubiquitin-like modifier (SUMO)-specific protease 2 (SENP2) has broad de-SUMOylation activities in vitro, which is essential for embryonic heart development. Silencing SENP2 can reduce myostatin expression and, therefore, promote myogenesis of skeletal muscle. These results reveal the important role of SEN... | yes |
571f59cd0fd6f91b68000008 | Is the Miller-Fisher syndrome considered to be a variant of Guillain-Barré? | Miller Fisher syndrome is a variant of Guillain-Barre syndrome characterized by the classic triad of ophthalmoplegia, ataxia, and areflexia We are reporting a rare case of Miller-Fisher (MFS) variant of Guillain-Barré syndrome (GBS) as the first manifestation of SLE in a 41-year-old female Miller-Fisher syndrome is def... | yes |
553a5a34bc4f83e82800001a | Is Ctf4 involved in sister chromatid cohesion establishment? | In addition to Eco1, several other factors contribute to cohesion establishment, including Ctf4, Ctf18, Tof1, Csm3, Chl1 and Mrc1, but little is known about their roles. Here, we show that each of these factors facilitates cohesin acetylation. Moreover, the absence of Ctf4 and Chl1, but not of the other factors, causes... | yes |
52ce531f03868f1b06000031 | Are retroviruses used for gene therapy? | Several immunodeficiencies have been treated successfully by stem cell-targeted, retroviral-mediated gene transfer with reconstitution of the immune system following infusion of the transduced cells. In this work we have developed and tested a self-inactivating (SIN) gammaretroviral vector (SINfes.gp91s) containing a c... | yes |
53354eafd6d3ac6a34000044 | Is there a phylogenetic analysis for HIV? | The results of Burst and phylogenetic analysis suggested that the C. neoformans var. grubii strains could be separated into three nonredundant evolutionary groups (Burst group 1 to group 3). Phylogenetic trees were constructed to evaluate the relationships between the variants We analyzed pol (protease/reverse transcr... | yes |
515d9e5c298dcd4e5100000e | Are there randomised controlled trials on sevoflurane? | After Ethics Review Board approval, 44 ASA I-III patients undergoing elective gynaecological surgery were randomised after surgery to either hypercapnic hyperpnoea or control groups. Hypercapnic hyperpnoea in spontaneously breathing patients halves the time of recovery from sevoflurane-induced anaesthesia in the operat... | yes |
52b2ec944003448f55000002 | Can FOXOs modulate longevity? | Forkhead box O (FOXO) transcription factors have a conserved function in regulating metazoan lifespan. In contrast to FoxO1, FoxO3a and FoxO6 were specifically diminished in the CNS of HFD animals possibly contributing to the reduced lifespan observed in these animals. Interestingly, many target proteins of AMPK are so... | yes |
56c1f042ef6e394741000056 | Is there an association between FGFR3 mutation and plagiocephaly? | Series of neurosurgical interventions were carried out, principally for acrocephaly and posterior plagiocephaly. The most common achondroplasia mutation, a p.Gly380Arg in the fibroblast growth factor receptor 3 (FGFR3) gene, was detected. The most common mutation for achondroplasia (FGFR3 Gly380Arg, resulting in 1138... | yes |
533bf29cc45e133714000001 | Are CD44 variants (CD44v) associated with poor prognosis of metastasis? | CD44 variants and prognosis The CD44 variant (CD44v) isoforms have been noted as markers for tumour metastasis and prognosis in several adenocarcinomas. Positive CD44v3 expression was associated with more advanced pathological stage and poorer prognosis than negative CD44v3 expression CD44v6 expression in the adenocarc... | yes |
515df98f298dcd4e51000030 | Is Bladder training an effective method to treat urge incontinence ? | Mindfulness-based stress reduction appears to be a treatment worthy of further study, as in the short term, it is as effective as historical studies of drug treatment and bladder training in reducing urge incontinence and incontinence-related quality of life. All patients, irrespective of the results of cystometry were... | yes |
513f3ab6bee46bd34c00000f | Do proton pump inhibitors affect thyroxine absorption? | Proton-pump inhibitors, antacids and a long list of drugs may decrease thyroxine absorption Many commonly used drugs, such as bile acid sequestrants, ferrous sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, phosphate binders, raloxifene and proton-pump inhibitors, have also been shown to interfer... | yes |
5357b5ecf1005d6b58000007 | Is PER3 required for CHK2 activation in human cells? | Per3, a circadian gene, is required for Chk2 activation in human cells. Depletion of Per3 by siRNA almost completely abolished activation of checkpoint kinase 2 (Chk2) after inducing DNA damage in human cells. Per3 overexpression induced Chk2 activation in the absence of exogenous DNA damage, Per3 overexpression also l... | yes |
5324cf869b2d7acc7e000020 | Are there any clinical trials of the effect of evening primrose oil on postmenopausal symptoms ? | To analyze whether the time (morning/evening) of administration of a compound containing 60 mg of dry soy seed extract (glycine max) with 40% of total isoflavones, primrose oil and α-tocopherol modifies the effect on the climacteric syndrome. The object of this study was to evaluate the effect of different doses of a c... | yes |
572099930fd6f91b6800000f | Is acid alpha-glucosidase the enzyme that causes Pompe disease when mutant? | Pompe disease is an autosomal recessive genetic disorder characterized by a deficiency of the enzyme responsible for degradation of lysosomal glycogen (acid α-glucosidase (GAA)) Pompe disease is a systemic metabolic disorder characterized by lack of acid-alpha glucosidase (GAA) resulting in ubiquitous lysosomal glycoge... | yes |
56e073ad51531f7e3300000e | Is the optogenetics tool ChR2 light-sensitive? | Channelrhodospin-2 (ChR2), a light-sensitive ion channel, and its variants have emerged as new excitatory optogenetic tools not only in neuroscience, but also in other areas, including cardiac electrophysiology. Light-sensitive genes chiefly including the genetically targeted light-gated channels channelrhodopsin-2 (Ch... | yes |
5727b6410fd6f91b6800001b | Is autism one of the characteristics of Moebius syndrome? | The diagnosis of Moebius syndrome, a rare congenital disorder, is primarily based on congenital facial and abducent nerve palsy. Involvement of other cranial nerves is also common. Occasionally the V, X, XI, and XII cranial nerves are involved, resulting in a difficulty to chew, swallow, and cough, which often leads to... | yes |
55016397e9bde69634000006 | Is Sarcolipin a regulatory/inhibitory protein of the Calcium ATPase SERCA? | The activity of SERCA is regulated by two small, homologous membrane proteins called phospholamban (PLB, also known as PLN) and sarcolipin (SLN). Detailed structural information explaining this regulatory mechanism has been lacking, and the structural features defining the pathway through which cytoplasmic Ca(2+) enter... | yes |
56bf7d90ef6e394741000015 | Is the circadian clock involved in ribosome biogenesis? | The circadian clock coordinates ribosome biogenesis. Here we show that the circadian clock exerts its function also through the regulation of mRNA translation. Namely, the circadian clock influences the temporal translation of a subset of mRNAs involved in ribosome biogenesis by controlling the transcription of transla... | yes |
52b2f0864003448f55000007 | Can mutations in Calmodulin cause ventricular fibrillation? | We characterized a family presenting with a history of ventricular fibrillation (VF) and sudden death without ECG or echocardiographic abnormalities at rest. Two siblings died suddenly at the ages of 9 and 10 years, and another two were resuscitated from out-of-hospital cardiac arrest with documented VF at age 10 and 1... | yes |
532f09d2d6d3ac6a3400002b | Is rivaroxaban metabolized in kidneys? | The novel oral anticoagulants (i.e., dabigatran, apixaban, rivaroxaban) all undergo renal metabolism to varying degrees, and hence dosing, efficacy, and safety require special consideration in CKD patients. The new oral anticoagulants have relatively little data in patients with severe renal impairment, and all have an... | yes |
55001420e9bde69634000005 | Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | Mowat-Wilson syndrome is a genetic disease caused by heterozygous mutations or deletions of the zinc finger E-box-binding homeobox 2 (ZEB2) gene. The syndrome is characterized by typical facial features, moderate-to-severe mental retardation, epilepsy and variable congenital malformations, including Hirschsprung diseas... | yes |
550c44d1a103b7801600000a | Is PLK2 involved in alpha-synuclein phosphorylation in the nervous system? | Polo-like kinase 2 (PLK2) phosphorylates alpha-synuclein at serine 129 in central nervous system Here we submit evidence that polo-like kinase 2 (PLK2, also known as serum-inducible kinase or SNK) is a principle contributor to alpha-synuclein phosphorylation at Ser-129 in neurons PLK2 directly phosphorylates alpha-synu... | yes |
55422640ccca0ce74b000004 | Does GC content vary markedly within a given isochore? | The isochore, a large DNA sequence with relatively small GC variance, is one of the most important structures in eukaryotic genomes. Isochores are large regions of relatively homogeneous nucleotide composition Vertebrate genomes are comprised of isochores that are relatively long (>100 kb) regions with a relatively hom... | no |
5317606eb166e2b80600000d | Is tubulin acetylation involved in cell motility? | In this study, we found that paclitaxel induced tubulin acetylation in endothelial and tumor cells, at concentrations that affected cell motility but not proliferation (10(-8) to 10(-9) M, for 4 hours). Induction of tubulin acetylation correlated with inhibition of motility but not proliferation based on a comparison o... | yes |
5148e42cd24251bc0500003b | Can PLN mutations lead to dilated cardiomyopathy? | A PLN founder mutation (43 cases) and LMNA mutations (19 cases, 16 different mutations) were most prevalent and often demonstrated a specific phenotype. PLN mutation R14del was identified in 12 (12 %) ARVC patients and in 39 (15 %) DCM patients The PLN R14del founder mutation is present in a substantial number of patie... | yes |
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