id stringlengths 24 24 | question stringlengths 21 168 | context stringlengths 79 19.2k | answer stringclasses 2
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56b8ed4b156496395c000004 | Is there any link between conserved noncoding elements and alternative splicing in vertebrates? | Some of the most highly conserved sequences occur in genes encoding RNA binding proteins, particularly the RNA splicing-associated SR genes. Differences in sequence conservation between plants and animals are likely to reflect differences in the biology of the organisms, with plants being much more able to tolerate gen... | yes |
57134d511174fb1755000002 | Is muscle regeneration possible in mdx mice with the use of induced mesenchymal stem cells? | Purified iMSCs displayed fibroblast-like morphology, formed three-dimensional spheroid structures, and expressed characteristic mesenchymal stem cell surface markers such as CD29, CD33, CD73, CD90, and CD105. Moreover, iMSCs were capable of differentiating into adipogenic, osteogenic, and chondrogenic lineages. Transpl... | yes |
571e06447de986d80d000016 | Is the SDHAF2 gene encoding a protein necessary for flavination of SDHA? | Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in SDHAF2, required for flavination of SDHA. At present, these are RET proto-oncogene, von Hippel-Lindau disease tumor suppressor gene (VHL), neurofibromatosis type 1 tumor su... | yes |
530cf4fe960c95ad0c00000a | Is zolpidem an antibiotic? | Zolpidem is a short-acting imidazopyridine hypnotic drug that is metabolized mainly by CYP3A4. FGIN-1-27 and alpidem, like the neurosteroid 3 alpha,21-dehydroxy-5 alpha-pregnane-20-one (THDOC), clonazepam and zolpidem (the direct allosteric modulators of gamma-aminobutyric acidA receptors) delay the onset of isoniazid ... | no |
530cf4fe960c95ad0c00000c | Can desvenlafaxine be used at a dose of 50mg/day? | Long-term use of desvenlafaxine was safe and well tolerated, with a clinical benefit/risk profile similar to that in other populations. e objective of this study was to evaluate the long-term safety of desvenlafaxine for continuation treatment of major depressive disorder (MDD) in Japanese patients. This was a phase 3,... | yes |
530cf4fe960c95ad0c00000d | Can ferric carboxymaltose be used to treat anemia in inflammatory bowel disease patients? | Intravenous iron should be preferred where oral iron is poorly tolerated or where it has failed in moderate to severe anemia, and in combination with erythropoietin Ferric carboxymaltose is much more convenient, and has been shown to be more effective than iron sucrose in a large randomized tria nemia and iron deficien... | yes |
54d63d873706e89528000006 | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | The most widely shared subset of genes-common to five of six disorders-included ANK3, AS3MT, CACNA1C, CACNB2, CNNM2, CSMD1, DPCR1, ITIH3, NT5C2, PPP1R11, SYNE1, TCF4, TENM4, TRIM26, and ZNRD1. Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associatio... | yes |
553fbe9fe00431e071000001 | Is the regulation of Vsr endonuclease independent of the growth phase of bacteria? | Growth phase-dependent regulation of Vsr endonuclease Vsr endonuclease levels are growth phase dependent. Growth phase-dependent regulation of Vsr endonuclease may contribute to 5-methylcytosine mutational hot spots in Escherichia coli. Using rabbit polyclonal antibodies, we have shown that the Dcm cytosine methylase o... | no |
56c85f675795f9a73e000013 | Are there interactomes available for POU5F1 and SOX2? | The interactomes of POU5F1 and SOX2 enhancers in human embryonic stem cells. We assayed long-range chromosomal interactions on putative enhancers of POU5F1 and SOX2 genes in human embryonic stem cells (hESCs) using 4C-Seq technique. We discovered that their frequent interacting regions mainly overlap with early DNA rep... | yes |
515ae990d24251bc050000ad | Is Rheumatoid Arthritis related to myopathy? | Prevalence of risk factors for statin-induced myopathy in rheumatoid arthritis patients we describe a patient with rheumatoid arthritis and respiratory failure associated with proximal myopathy secondary to HCQ Occurrence of chloroquine-induced myopathy after low-dose treatment of rheumatoid arthritis for seven years a... | yes |
570908e3cf1c325851000012 | Is EZH2 associated with prostate cancer? | The role of EZH2 in the regulation of the activity of matrix metalloproteinases in prostate cancer cells EZH2 plays an active role in this process by repressing the expression of TIMP2 and TIMP3 in prostate cancer cells The TIMP genes are derepressed by knockdown of EZH2 expression in human prostate cancer cells but re... | yes |
5319a7b2b166e2b806000028 | Is there any cross-talk between the Wnt and the Akt pathways? | Our data demonstrate that engaging Wnt signaling at the receptor level by this method leads to necessary crosstalk between multiple signaling pathways including activation of Akt, mTOR, Wnt/β-catenin, PKA/CREB, and inhibition of RhoA/ROCK that substantially increase human β-cell proliferation while maintaining the β-ce... | yes |
5523e8cc7b523f2123000007 | Has the protein GFP been used in transgenesis for live protein imaging? | we review recent advancement in the functional studies of the three different GnRH neuron systems, mainly focusing on the electrophysiological analysis of the GnRH-green fluorescent protein (GFP) transgenic animals. founders were found to be transgenic for GFP. GFP expression was detected in a wide range of murine tiss... | yes |
52b2f0d84003448f55000009 | Is the Snord116 cluster associated with the Prader-Willi syndrome? | All three deletions included SNORD116, but only two encompassed parts of SNURF-SNRPN, implicating SNORD116 as the major contributor to the Prader-Willi phenotype. Our case adds further information about genotype-phenotype correlation and supports the hypothesis that SNORD116 plays a major role in the pathogenesis of Pr... | yes |
53380000d6d3ac6a34000059 | Is poly (ADP- ribosylation) involved in transcriptional control? | Histone phosphorylation, ubiquitylation, SUMOylation and poly-ADP-ribosylation, as well as ATP-dependent nucleosome remodeling complexes, play equally pivotal roles in the maintenance of transcriptional fidelity oly(ADP-ribose) polymerase-1 (PARP-1; EC 2.4.2.30) is an abundant nuclear protein that is involved in DNA re... | yes |
51490275d24251bc0500003d | Is nimodipine recommended for prevention of vasospasm in aneurysmal subarachnoid hemorrhage patients? | This article discusses some of these unresolved issues, including the use of medications such as nimodipine, antifibrinolytics, statins, and magnesium; coiling or clipping for aneurysm securement; and the prevention and treatment of potential complications. The results of this study were as follows: nimodipine demonstr... | yes |
56c1f002ef6e394741000038 | Is lenvatinib effective for thyroid cancer? | New insights in the treatment of radioiodine refractory differentiated thyroid carcinomas: to lenvatinib and beyond. However, even more impressive responses and progression-free survival benefits were seen in the phase III SELECT trial with lenvatinib, giving even higher hopes for the future management of what was cons... | yes |
56c0968def6e394741000026 | Was tamoxifen tested for treatment of glioma patients? | Tamoxifen might have a role in the initial treatment of high-grade gliomas and should be studied in future Phase II trials building on the newly established platform of concurrent chemoradiotherapy. The addition of high-dose tamoxifen to standard radiotherapy does not improve the survival of patients with diffuse intri... | yes |
532f0ca1d6d3ac6a3400002f | Are there any animal models for Niemann-Pick C1 disease? | Several animal models were used to analyze the impaired pathways. We investigated components of the surfactant system in both NPC1 mutant mice and felines and in NPC2 mutant mice near the end of their expected life span. Thus far, studies of NPC mice have been performed mainly to study the brain and neurodegeneration... | yes |
51542eacd24251bc05000084 | Does HER2 under-expression lead to favorable response to trastuzumab? | over-expression of HER2 is reported in approximately 20% of gastric tumours, challenging the use of targeted therapies. In patients with advanced gastric or gastro-oesophageal junction cancer, addition of trastuzumab to chemotherapy significantly improved overall survival compared with chemotherapy alone. Addition of ... | no |
52ffb5d12059c6d71c00007c | Is the PTPN22 gene a biomarker for rheumatoid arthritis? | TPN22 is a tyrosine phosphatase and functions as a damper of TCR signals. A C-to-T single nucleotide polymorphism (SNP) located at position 1858 of human PTPN22 cDNA and converting an arginine (R620) to tryptophan (W620) confers the highest risk of rheumatoid arthritis among non-HLA genetic variations that are known to... | yes |
5314d0e4dae131f84700000e | Can administration of the thyrotropin releasing hormone reduce fatigue in cancer patients? | TRH administration was associated with significant improvement (p < 0.05) in fatigue levels as measured by the Visual Analog Scale-Energy (VAS-E), was associated with significant (p < 0.05) improvement in sleep disturbances and improved quality of life. This decrease in CRP level with TRH administration was associated... | yes |
56b0eb3b0a360a5e45000019 | Is curcumin a phytochemical? | we analyzed turmeric from different agroclimatic regions for influence of various factors on its growth and yield of important phytochemicals The phytochemical, curcumin, has been reported to play many beneficial roles. Curcumin (CUR), the major component in Curcuma longa, has been shown as a potent chemopreventive phy... | yes |
54ede5c394afd61504000006 | Is Fanconi anemia presented as a genetically and clinically heterogeneous disease entity? | Fanconi anaemia (FA) is a rare, autosomal recessive, genetically complex, DNA repair deficiency syndrome in man. Patients with FA exhibit a heterogeneous spectrum of clinical features. The most significant and consistent phenotypic characteristics are stem cell loss, causing progressive bone marrow failure and sterilit... | yes |
56ae71cb0a360a5e45000010 | Is there evidence for de novo genesis of enhancers in vertebrates? | De novo genesis of enhancers in vertebrates. Evolutionary innovation relies partially on changes in gene regulation. While a growing body of evidence demonstrates that such innovation is generated by functional changes or translocation of regulatory elements via mobile genetic elements, the de novo generation of enhanc... | yes |
551c4ffc6b348bb82c000010 | Is TNNI3K a cardiac-specific protein? | cardiomyocyte-specific kinase TNNI3K We report that cardiac troponin I-interacting kinase (TNNI3K), a cardiomyocyte-specific kinase, TNNI3K, a cardiac-specific kinase, The cardiac troponin I-interacting kinase (TNNI3K), a novel cardiac specific kinase, is associated with cardiomyocyte hypertrophy Human cardiac tropo... | yes |
51588c1ad24251bc05000094 | Is factor XI deficient in Hemophilia C? | Factor XI deficiency is a rare hematologic disorder. Hemophilia C (factor XI deficiency) affects both genders and it is usually asymptomatic, Congenital factor XI deficiency (also known as the Rosenthal syndrome or hemophilia C) rare case of an acute cerebral aneurysm rupture in a patient with a known factor XI deficie... | yes |
551910c5622b194345000007 | Are EDNRB mutations involved in the development of Hirschsprung disease? | QTL analysis identifies a modifier locus of aganglionosis in the rat model of Hirschsprung disease carrying Ednrb(sl) mutations As reported previously, when the same null mutation of the Ednrb gene, Ednrb(sl), was introgressed into the F344 strain, almost 60% of F344-Ednrb(sl/sl) pups did not show any symptoms of agang... | yes |
5717bacacb4ef8864c00000d | Can the apoptosis regulator BAX trigger the release of cytochrome c? | 6-Shogaol reduced the mitochondrial membrane potential (MMP) and released cytochrome c from mitochondria to cytosol via Bax activation. Moreover, overexpression of ERβ prevented Bax activation, cytochrome c release, caspase-3 activation, and PARP cleavage during apoptosis. In this study, we demonstrated that EV71 infe... | yes |
56e0797451531f7e3300000f | Are optogenetics tools used in the study and treatment of epilepsy? | The emerging revolutionary technique of optogenetics enables manipulation of the activity of specific neuronal populations in vivo with exquisite spatiotemporal resolution using light. We used optogenetic approaches to test the role of hippocampal excitatory neurons in the lithium-pilocarpine model of acute elicited se... | yes |
54f4627e64850a5854000007 | Is micro RNA 1 (miR-1) implicated in cardiac arrhythmias? | Dysfunction of the gap junction protein connexin 43 (Cx43), an established miR-1 target, during cardiac hypertrophy leads to ventricular tachyarrhythmias (VT). miR-1 overexpression may contribute to the increased susceptibility of the heart to AVB, which provides us novel insights into the molecular mechanisms underlyi... | yes |
516c1041298dcd4e51000070 | Does thyroid hormone signaling affect microRNAs expression in the heart? | e show that the heart regulates systemic energy homeostasis via MED13, a subunit of the Mediator complex, which controls transcription by thyroid hormone and other nuclear hormone receptors. MED13, in turn, is negatively regulated by a heart-specific microRNA, miR-208a. On the other hand, T₃ treatment increased miR-350... | yes |
5547d72ef35db75526000008 | Do all archaea possess multiple origins of DNA replication? | Origins differ in number and structure across the three domains of life and their properties determine the dynamics of chromosome replication. Bacteria and some archaea replicate from single origins, whereas most archaea and all eukaryotes replicate using multiple origins. Replication starts at a single Ori site in bac... | no |
55088e412e93f0133a000001 | Is p100 the precursor protein molecule of the NF-kappaB transcription factor subunit p50? | We previously reported that alymphoplasia (aly/aly) mice, which have a natural loss-of-function mutation in the Nik gene, which encodes a kinase essential for the processing of p100 to p52 in the alternative nuclear factor-κB (NF-κB) pathway, show mild osteopetrosis with an increase in several parameters of bone format... | no |
5149b575d24251bc05000047 | Is there a difference in the rate between gene fusion and gene fission? | we illustrate arrangement diversity within closely related organisms, estimate arrangement turnover frequency and establish, for the first time, branch-specific rate estimates for fusion, fission, domain addition and terminal loss. Rate and polarity of gene fusion and fission in Oryza sativa and Arabidopsis thaliana We... | yes |
54d762653706e89528000014 | Can cognitive behavioral therapy improve fatigue in cancer patients? | Physical activity, educational interventions, and cognitive-behavioral therapy have the most supportive data and can be recommended to patients with confidence. For women undergoing radiotherapy (3 RCTs), hypnosis combined with cognitive-behavioral therapy improved distress and fatigue. Patients in the CBT group repor... | yes |
550ae16bc2af5d5b70000009 | Is protein Fbw7 a SCF type of E3 ubiquitin ligase? | FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box protein)-type ubiquitin ligase. However, very few E3 ubiquitin ligases are known to target G-CSFR for ubiquitin-proteasome pathway. Here we identified F-box and WD repe... | yes |
5361677c7d100faa09000008 | Is there increased incidence of incontinence in athletes? | Urinary incontinence affects women of all ages, including top female athletes, but is often under-reported. The highest prevalence of urinary incontinence is reported in those participating in high impact sports. The prevalence of female stress urinary incontinence is high, and young adults are also affected, including... | yes |
56a8adb0a17756b72f000003 | Are there enhancer RNAs (eRNAs)? | active enhancers are transcribed, producing a class of noncoding RNAs called enhancer RNAs (eRNAs). eRNAs are distinct from long noncoding RNAs (lncRNAs), but these two species of noncoding RNAs may share a similar role in the activation of mRNA transcription eRNAs may then facilitate enhancer-promoter interaction or ... | yes |
56b8a222156496395c000001 | Are conserved noncoding elements associated with the evolution of animal body plans? | Here, we discuss the evidence that CNEs are part of the core gene regulatory networks (GRNs) that specify alternative animal body plans. The major animal groups arose>550 million years ago. We propose that the cis-regulatory inputs identified by CNEs arose during the "re-wiring" of regulatory interactions that occurred... | yes |
56ae69fb0a360a5e4500000d | Are DNA methylation maps applicable to the diagnosis of non-small-cell lung carcinomas? | Here we present a genome-wide DNA methylation analysis of NSCLC samples and paired lung tissues, where we combine MethylCap and next generation sequencing (MethylCap-seq) to provide comprehensive DNA methylation maps of the tumor and paired lung samples. Analysis of the MethylCap-seq data revealed a strong positive cor... | yes |
550aef0ec2af5d5b7000000a | Is the protein product of the cylindromatosis gene (CYLD) a deubiquitinating enzyme? | CYLD was originally identified as a tumor suppressor gene mutated in familial cylindromatosis, an autosomal dominant predisposition to multiple benign neoplasms of the skin known as cylindromas. The CYLD protein is a deubiquitinating enzyme that acts as a negative regulator of NF-κB and JNK signaling through its intera... | yes |
531d34be267d7dd053000004 | Has the presence of delayed enhancement been documented in athletes performing strenuous exercise? | Atypical findings such as marked cardiac dilation, reduced deformation, or small patches of delayed gadolinium enhancement may be commonly encountered in well-trained athletes, but, at present, the prognostic significance of such findings is unknown. On CMR, DGE localized to the interventricular septum was identified ... | yes |
52b2f09f4003448f55000008 | Is triadin involved in cardiac function? | Junctin (JCN), a 26-kd sarcoplasmic reticulum (SR) transmembrane protein, forms a quaternary protein complex with the ryanodine receptor, calsequestrin, and triadin in the SR lumen of cardiac muscle. Within this complex, calsequestrin, triadin, and JCN appear to be critical for normal regulation of ryanodine receptor-m... | yes |
51487821d24251bc0500002f | Is Mammaprint approved by the United States Food and Drug Administration? | an FDA-cleared 70-gene signature of MammaPrint panel on MammaPrint, the first and only assay for breast cancer management that has been cleared by the FDA. The MammaPrint assay has the advantages of a 510(k) clearance by the US Food and Drug Administration, a larger gene number which may enhance further utility, and t... | yes |
53636e727d100faa0900000d | Are microRNA (miR) regulated through DNA methylation of their promoters? | We found that Tcf3 down-regulation in the context of constitutively active Wnt signaling does not result from promoter DNA methylation but is likely to be caused by a plethora of mechanisms at both the RNA and protein level as shown by the observed decrease in activating histone marks (H3K4me3 and H3-acetylation) and t... | yes |
513596225274a5fb0700000d | Are nucleosomes positioned at DNA replication origins? | yeast origins are characterized by an asymmetric pattern of positioned nucleosomes flanking the ACS. The origin sequences are sufficient to maintain a nucleosome-free origin; however, ORC is required for the precise positioning of nucleosomes flanking the origin. Here, we identify nucleosome occupancy as a likely candi... | no |
54d901ec4b1fd0d33c000006 | Does nimotuzumab improve survival of glioblastoma patients? | The survival times were similar to those seen in historical data of standard therapy. The survival time of a matched population treated at the same hospital with irradiation alone was decreased (median 8.0 and 12.2 mo for GBM and AA patients, respectively) compared with that of the patients who received nimotuzumab and... | yes |
5321b8a39b2d7acc7e000009 | Is there a relation between ANP and transcapillary albumin escape? | Thus, in a large ethnically homogeneous cohort of diabetic subjects, our data show: (1) a significant association of C708/T polymorphism with microalbuminuria in long-term diabetes and with both lower plasma ANP levels and widespread albumin leakage hese results suggest a possible role of PND gene in conferring protect... | yes |
56d34fbcf22319765a000009 | Can chronological age be predicted by measuring telomere length? | Human somatic cells gradually lose telomeric repeats with age. This study investigated if one could use a correlation between telomere length and age, to predict the age of an individual from their DNA. Therefore, telomere length measurement by real-time quantitative PCR cannot be used to predict age of a person, due t... | no |
514cbbf9d24251bc05000065 | Is there an association between c-reactive protein concentrations and outcomes of subarachnoid hemorrhage patients? | Besides the baseline characteristics, daily interleukin-6 (IL-6), procalcitonin, C-reactive protein levels, and leukocyte counts were prospectively measured until day 14 after subarachnoid hemorrhage. Occurrence of infectious complications and application of therapeutic hypothermia were assessed as confounding factors.... | yes |
53372b66d6d3ac6a34000057 | Can RNASeq be used for the analysis of nascent transcripts? | Here, we utilize nascent RNA sequencing to document dosage compensation during transcriptional elongation. Here we show that RNA-seq can also be used for studying nascent RNAs undergoing transcription Conversely, the nuclear fraction shows an enrichment of unprocessed RNA compared with total RNA-seq, making it suitable... | yes |
56e310a151531f7e33000017 | Do RNA:DNA hybrids preferentially form in high or low GC regions? | Intrinsic termination signals for multisubunit bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [poly(U)] tract, and it has been proposed that steric clash of the stem-loop with the exit pore of the RNAP imposes a shearing force on the RNA in the downstream RNA:DNA hybrid... | yes |
56a292ae496b62f23f000001 | Are shadow enhancers associated with development? | Critical developmental control genes sometimes contain "shadow" enhancers that can be located in remote positions, including the introns of neighboring genes These results suggest that shadow enhancers represent a novel mechanism of canalization whereby complex developmental processes "bring about one definite end-resu... | yes |
53319653d6d3ac6a3400003e | Does prudent diet reduce cardiovascular risk? | Using this approach, large prospective studies have reported reductions in CVD risk ranging from 10 to 60% in groups whose diets can be variously classified as ‘Healthy’, ‘Prudent’, Mediterranean’ or ‘DASH compliant’. Our findings suggest that a heart healthy dietary pattern is associated with moderately reduced risk o... | yes |
553a54babc4f83e828000019 | Are there Conserved Noncoding Elements (CNEs) in plant genomes? | Conservation and functional element discovery in 20 angiosperm plant genomes The detailed view of conservation across angiosperms revealed not only high coding-sequence conservation but also a large set of previously uncharacterized intergenic conservation Conserved noncoding sequences highlight shared components of re... | yes |
530cf4fe960c95ad0c000009 | Can tetracycline affect tooth formation? | he results of that study, reported earlier (Rebich et al., 1983), indicated that over one-fifth of the American Indian children had discoloration of the dentition due to ingestion of tetracycline during the years of tooth formatio ale Wistar rats prelabeled with tetracycline to mark surfaces of bone and tooth formation... | yes |
530cf4fe960c95ad0c000003 | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | Here we refine our approach, and apply it to novel variants found in 2266 patients across two large cohorts with inherited sudden death syndromes, namely catecholaminergic polymorphic ventricular tachycardia (CPVT) or Brugada syndrome (BrS). Calsequestrin-associated catecholaminergic polymorphic ventricular tachycardia... | yes |
530cf4fe960c95ad0c000002 | Does Apolipoprotein E (ApoE) have anti-inflammatory activity? | have previously reported that apolipoprotein E (apoE), a protein component of very-low-density lipoproteins (VLDL) and high-density lipoproteins and a potent plasma-borne atheroprotective factor, exerts anti-inflammatory activity in macrophages by switching the activation profile from M1 ("classic") to M2 ("alternative... | yes |
530cf4fe960c95ad0c000005 | Is the ACE inhibitor indicated for lung cancer treatment? | The angiotensin converting enzyme (ACE) inhibitors are used widely as antihypertensive agents, and it has been suggested that they decrease the risk of some cancers, although available data are conflicting. Using cell viability and fluorescent activated cell sorting analysis tests, we demonstrated that captopril inhib... | no |
55425615ed966d112c000003 | Are genes symmetrically distributed between leading and lagging DNA strand in bacteria? | Genomic DNA is used as the template for both replication and transcription, whose machineries may collide and result in mutagenesis, among other damages. Because head-on collisions are more deleterious than codirectional collisions, genes should be preferentially encoded on the leading strand to avoid head-on collision... | no |
531616bdb166e2b806000003 | Is c-myc subject to regulation by the circadian clock? | The current study encompasses the investigation of simultaneous expression of four circadian clock genes (Bmal1, Clock, Per1 and Per2) and three clock-controlled cell cycle genes (Myc, Cyclin D1 and Wee1) Our results suggest that aberrant expression of circadian clock genes can lead to aberrant expression of their down... | yes |
531c380db166e2b80600003f | is there an increase in ultrasound comets after intense exercise? | Healthy athletes developed subclinical increase in pulmonary water content immediately after an Ironman race at sea level, as shown by the increased number of ULCs related to cardiac changes occurring during exercise. Increased EVLW is associated with estimated PCWP and indices of left ventricular systolic and diastoli... | yes |
57135fae1174fb1755000004 | Can cffDNA be used for non-invasive testing? | Non-invasive prenatal testing using cell-free fetal DNA in maternal circulation The identification of cell-free fetal DNA (cffDNA) in maternal circulation has made non-invasive prenatal testing (NIPT) possible. In recent years, technical advances in the molecular analysis of fetal DNA (e.g., digital PCR and massively p... | yes |
56cab4c75795f9a73e00001f | Do U6-associated proteins Lsm4 and Lsm6 interact with SMN? | SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6. Interestingly, SMN also interacts with at least two of the U6-associated Sm-like (Lsm) proteins, Lsm4 and Lsm6 Furthermore, we present evidence for two separate binding sites in SMN for Sm/Lsm proteins. Interestingly, SMN ... | yes |
56cf2a153975bb303a000004 | Does MVIIA and MVIIC bind to the same calcium channel? | We examined the post-pubertal behavioral effects of neonatal (postnatal day 7) medial prefrontal cortex infusion of either vehicle or N-type and P/Q-type presynaptic voltage-dependent calcium channel blockers (omega-conotoxins MVIIA and MVIIC respectively; 6.8 and 45 pmol infused respectively) in rat pups. Additionally... | no |
56f7d9dd09dd18d46b000014 | Is arimoclomol a co-inducer of the heat shock response? | Arimoclomol is a hydroxylamine derivative, a group of compounds which have unique properties as co-inducers of heat shock protein expression, but only under conditions of cellular stress. In this review we summarize the evidence for the neuroprotective effects of enhanced heat shock protein expression by Arimoclomol a... | yes |
536172d17d100faa09000009 | Has silicon been used in treatment of incontinence ? | an artificial anal sphincter. Worldwide, there are two established devices on the market: the artificial bowel sphincter® (ABS) from A. M. S. (Minnetonka, MN, USA) and the soft anal band® from A. M. I. (Feldkirch, Austria). How to implant the artificial anal sphincter? Both devices consist of a silicon cuff which can b... | yes |
56ebfac12ac5ed1459000001 | Does the 3D structure of the genome remain stable during cell differentiation? | We identify large, megabase-sized local chromatin interaction domains, which we term 'topological domains', as a pervasive structural feature of the genome organization. The domains are stable across different cell types and highly conserved across species, indicating that topological domains are an inherent property o... | no |
516d4b27298dcd4e51000077 | Does dronedarone affect T3 and T4 levels? | Amiodarone resulted in increased T4, T4/T3 and rT3, whereas dronedarone did not alter the thyroid hormone profile in normal animals. Fifty-five Wistar rats were randomly allocated to a 2-week oral treatment with either vehicle (n=18), amiodarone (30 mg/kg, n=20), or dronedarone (30 mg/kg, n=17). Thyroid function was si... | no |
513f4892bee46bd34c000014 | Does triiodothyronine (T3) has cardiac angiogenic effects? | T3-induced cardiac sprouting angiogenesis in adult hypothyroid mice was associated with PDGF-BB, PDGFR-β and downstream activation of Akt. L-T3 significantly increased angiogenesis and cell survival and enhanced the expression of nuclear-encoded transcription factors involved in these processes. T(3) administration res... | yes |
54d8f37b4b1fd0d33c000004 | Is the HRC Ser96Ala variant associated with sudden cardiac death in patients with dilated cardiomyopathy? | The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM. The Ser96Ala (S96A) mutation within the histidine rich Ca(2+) binding protein (HRC) has recently been l... | yes |
5512c91b6a8cde6b7200000b | Are BRAF mutations common in melanoma? | patients with BRAF-mutant melanoma. BRAF-mutated melanoma The RAS/RAF/MEK/ERK pathway has been reported to be activated in over 80% of all cutaneous melanomas, making it the focus of many scientific studies in the melanoma field. Discoveries of mutations and aberrant expression of components in this cascade, in partic... | yes |
511a1e12df1ebcce7d000009 | Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) tissue? | ver the last few years, advances in methodology have made it possible to recover peptides from FFPE tissues that yield a reasonable representation of the proteins recovered from identical fresh or frozen specimens. Thus, laser capture microdissection of FFPE tissue coupled with downstream proteomic analysis is a valid ... | yes |
550311dae9bde69634000018 | Is aganglionic megacolon a feature of Down syndrome? | Down syndrome (DS) is recognized by characteristic facial features, intellectual disability, and an increased risk for cardiac malformations and duodenal atresia. Recently, Hirschsprung disease (HSCR), or congenital aganglionic megacolon, has been seen more often among patients with DS Of the 17 patients with HD who we... | yes |
56c5a7605795f9a73e000002 | Does HuR protein regulate the splicing process? | HuR and TIA1/TIAL1 are involved in regulation of alternative splicing of SIRT1 pre-mRNA Here we describe experiments showing that HuR and TIA1/TIAL1, two kinds of RNA-binding proteins, were involved in the regulation of alternative splicing of SIRT1 pre-mRNA under normal and stress circumstances HuR increased SIRT1-∆Ex... | yes |
55030a6ce9bde6963400000f | Is Titin the largest single protein molecule found in Nature? | Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. Titin is the largest protein in mammals; it forms an elastic filament along the myofibril of cardiac and skeletal muscles. Titin is recently known as the largest protein w... | yes |
532627d0d6d3ac6a34000001 | Does ventriculoperitoneal shunt improve normal pressure hydrocephalus? | Clinical improvement depends not only on the capability to restore the cerebrospinal fluid dynamic, but also on the ability of cerebral parenchyma to recover the metabolic function. After shunting, the global CMRglu significantly increased (2.95 ± 0.44 vs 4.38 ± 0.68, p = 10(-7)) in all INPH patients with a mean perce... | yes |
51680b05298dcd4e51000064 | Does Serca2a bind PLN in the heart? | The human phospholamban Arg14-deletion mutant localizes to plasma membrane and interacts with the Na/K-ATPase. Moreover, PLN-R14Del did not co-immunoprecipitate with SERCA2a (as did WT-PLN), n this review, we attempted to highlight the functional significance of PLN in vertebrate cardiac physiology. We will refer to th... | yes |
56d1d56b67f0cb3d66000004 | Is there any role for long noncoding RNAs in adipogenesis? | Long noncoding RNAs regulate adipogenesis. Here we profiled the transcriptome of primary brown and white adipocytes, preadipocytes, and cultured adipocytes and identified 175 lncRNAs that are specifically regulated during adipogenesis. Many lncRNAs are adipose-enriched, strongly induced during adipogenesis, and bound a... | yes |
532bf6f2d6d3ac6a34000015 | Is there any research that relates the function of Notch Signaling with Alzheimer Disease? | RIP regulates signaling pathways by abrogating or releasing signaling molecules. Since the discovery, already >15 years ago, of its catalytic component, presenilin, and even much earlier with the identification of amyloid precursor protein as its first substrate, γ-secretase has been commonly associated with Alzheimer'... | yes |
54fc845e6ea36a810c000005 | Was modafinil tested for schizophrenia treatment? | Modafinil improves antipsychotic-induced parkinsonism but not excessive daytime sleepiness, psychiatric symptoms or cognition in schizophrenia and schizoaffective disorder: a randomized, double-blind, placebo-controlled study. CONCLUSION: The data suggest that modafinil was a safe adjunctive treatment which improved pa... | yes |
514cc8dcd24251bc05000066 | Is depression associated with poor prognosis of brain tumor patients? | Before surgery 27 patients (35%) had BDI scores indicating the presence of depression. These scores were significantly higher in patients with a history of depression (p = 0.017) and in those with a lower functional outcome (p = 0.015). A lower functional status (KPS score < or = 70) in patients was significantly assoc... | yes |
5161cfa3298dcd4e5100003d | Have germline variants been associated to colorectal cancer? | Overall, we identified aberrant transcripts in 8% of the patients (familial cases 30%; early-onset manifestation 21%). In eight of them, two different out-of-frame pseudoexons were found consisting of a 167-bp insertion from intron 4 in five families with a shared founder haplotype and a 83-bp insertion from intron 10 ... | yes |
5156beb4d24251bc05000089 | Can Alzheimer's disease related miRNAs be detected in patients' blood? | miRNAs are aberrantly expressed in AD, and these have been implicated in the regulation of amyloid-β (Aβ) peptide, tau, inflammation, cell death, and other aspects which are the main pathomechanisms of AD. In addition, regulation of miRNAs varies in blood, and cerebral spinal fluid may indicate alterations in AD. miRNA... | yes |
54cf449cf693c3b16b000009 | Is it possible to visualize subtahalamic nucleus by using transcranial ultrasound? | After measuring thermal effects of TCS and imaging artefact sizes of DBS lead using a skull phantom, we prospectively enrolled 34 patients with DBS of globus pallidus internus, ventro-intermediate thalamic or subthalamic nucleus. TCS had no influence on lead temperature, electrical parameters of DBS device or clinical ... | yes |
533e50fdc45e13371400000f | Do thyroid hormone receptors change after brain injury? | For example, the T3 receptor alpha was predominantly expressed in stroke-tissue, indicating that regeneration of nerves in stroke tissue may be facilitated by increased T3 receptor alpha expression. TRα expression was also increased in human infants with IVH. Thus, in infants with IVH the combined elevation in deiodin... | yes |
5321ae889b2d7acc7e000006 | Is gastro esophageal reflux related to burning mouth syndrome? | Our results suggest that there is no causal connection between LPR episodes and the occurrence of intraoral burning sensations in the examined patients. As reported below, although this symptom may well be diagnostically misleading, careful diagnosis based on clinical signs may distinguish patients with BMS from those ... | no |
513cdc38bee46bd34c000007 | Is thrombophilia related to increased risk of miscarriage? | Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH for illustrative purposes, a patient presenting with combined thrombophilia--both genetic and acquired--will be discussed. This patient had suffered severe gestational complications that led to devastating obstetrical outcome... | yes |
56c313d150c68dd416000002 | Does nifedipine inhibit L-type calcium channels? | Nifedipine, an L-type calcium channel blocker, reduced the expression of synaptogamin and syntaxin and blocked the suppressive effect of vecuronium, suggesting that both agents inhibit presynaptic L-type calcium channels. Treatment with nifedipine to inhibit calcium influx via the L-type channel Cav1.2 (alpha(1C)) inhi... | yes |
54d76ac63706e89528000016 | Is there any data to suggest that TRH (thyrotropin releasing hormone) administration can improve symptom severity of amyotrophic lateral sclerosis patients? | These central nervous system (CNS)-mediated effects provide the rationale for use of TRH and its analogs in the treatment of brain and spinal injury, and CNS disorders like schizophrenia, Alzheimer's disease, epilepsy, amyotrophic lateral sclerosis, Parkinson's disease, depression, shock and ischemia. The Effect of TRH... | yes |
54297ed2289fd6cb07000001 | Can siRNA affect response to afatinib treatment? | On the other hand, miR-146a enhanced the inhibition of cell proliferation by drugs targeting EGFR, including both TKIs (gefitinib, erlotinib, and afatinib) and a monoclonal antibody (cetuximab) These effects were independent of the EGFR mutation status (wild type, sensitizing mutation or resistance mutation), but were ... | yes |
517a8a718ed59a060a00003e | Does triiodothyronine stimulate red blood cell sodium potassium pump? | reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels. The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes. at hyperthyroid pat... | no |
56c1f00aef6e39474100003d | Is selumetinib effective in thyroid cancer? | A phase I trial of vertical inhibition of IGF signalling using cixutumumab, an anti-IGF-1R antibody, and selumetinib, an MEK 1/2 inhibitor, in advanced solid tumours. BACKGROUND: We completed a phase I clinical trial to test the safety and toxicity of combined treatment with cixutumumab (anti-IGF-1R antibody) and selum... | yes |
56cae51f5795f9a73e000025 | Are immune cells affected in Amyotrophic Lateral Sclerosis? | Therapeutic immunization of mSOD1 mice with a myelin-derived peptide led to CP activation, and was followed by the accumulation of immunoregulatory cells, including IL-10-producing monocyte-derived macrophages and Foxp3(+) regulatory T cells, and elevation of the neurotrophic factors IGF-1 and GDNF in the diseased spin... | yes |
531b4269b166e2b80600003e | Is thyroid hormone therapy indicated in patients with heart failure? | Patients with chronic heart failure and subclinical hypothyroidism significantly improved their physical performance when normal TSH levels were reached. Early and sustained physiological restoration of circulating L-T3 levels after MI halves infarct scar size and prevents the progression towards heart failure. This be... | no |
54edf05494afd6150400000e | Is there a mouse model for Fanconi anemia? | Cyclophosphamide promotes engraftment of gene-modified cells in a mouse model of Fanconi anemia without causing cytogenetic abnormalities We compared Cy preconditioning with fludarabine (Flu) or cytarabine (AraC) or no conditioning as a control in fanca ( -/- ) mutant mice receiving gene-modified bone marrow cells We c... | yes |
553fb11fc6a5098552000003 | Could Hyperthermic intraperitoneal chemotherapy (HIPEC) be effective for the treatment of recurrent ovarian cancer? | The use of HIPEC after aggressive cytoreductive surgery in patients with ovarian cancer with peritoneal dissemination can be performed with acceptable postoperative morbidity rates. Knowledge of the factors associated with the onset of these postoperative adverse events allows better management of the same and offers t... | yes |
5319abc9b166e2b80600002d | Is Rac1 involved in cancer cell invasion? | In the Matrigel invasion assay, knockdown of CCR1 and inhibition of the ERK and Rac signaling pathways significantly decreased the number of invading cells. These results demonstrated for the first time that the interaction of CCR1 with CCL5 caused by increased expression of CCR1 promotes invasion of PC3PR cells by inc... | yes |
56d8ba1851531f7e33000005 | Is the gene SLC6A2 associated with orthostatic intolerance? | Orthostatic intolerance is a debilitating syndrome characterized by tachycardia on assumption of upright posture. The norepinephrine (NE) transporter (NET) has been implicated in a genetic form of the disorder. Thus attenuated baroreflex function and reduced sympathetic outflow may contribute to the orthostatic intole... | yes |
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