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Pts with treatment-naive CD20+ B-cell FL and ≥1 bi-dimensionally measurable lesion (CT scan; largest dimension >1.5cm) were allocated on a per-center basis to receive induction G IV 1000mg + standard CHOP (3-weekly, 6–8 cycles) or B IV 90mg/m2(4-weekly, 4–6 cycles). Induction responders received G-maintenance every 3 m... |
The overall safety population comprised 81 pts (G-B: n=41; G-CHOP: n=40). Baseline characteristics (age, sex, FLIPI status, bone marrow involvement, bulky disease [lesion ≥7cm], time from diagnosis) were balanced between arms. Median observation time from study start was 31 months (G-B) and 33 months (G-CHOP). |
The maintenance safety population comprised 72 pts (n=36 from each induction therapy arm). Most pts completed maintenance (G-B: 81%; G-CHOP: 72%). There were 17 discontinuations (24%; G-B: n=7; G-CHOP: n=10), due to an adverse event (AE)/intercurrent illness (n=9), insufficient therapeutic response (n=5), administrativ... |
During 2 years’ maintenance most pts had AEs: G-B, 100% (44% grade ≥3); G-CHOP, 78% (31% grade ≥3). The most common AE (all grades) was cough (G-B: 17%; G-CHOP: 11%). The grade ≥3 AEs mainly reflected infections and cytopenia. Six G-B pts (17%) experienced 7 grade ≥3 infections; 4 were considered treatment related (gen... |
At the end of maintenance, all pts with data available (G-B: n=41; G-CHOP: n=39) had experienced B-cell depletion ( 0.07x109cells/L). Median IgG levels remained within normal range during maintenance. |
In the overall safety population, complete response (CR) rate (based on CT scan rather than PET) as best overall response increased from end of induction (G-B: 37%; G-CHOP: 35%) to end of maintenance (G-B: 61%; G-CHOP: 70%). PFS rate at 32 months after first study drug was 92% (G-B) and 84% (G-CHOP). Median PFS was not... |
G-maintenance after G-chemotherapy induction was associated with a high CR rate in pts with previously untreated FL. Opportunistic infections occurred infrequently. Clinically relevant neutropenia was experienced by 14% of pts who received G-B induction but was not observed in G-CHOP pts. A phase III trial (GALLIUM) is... |
Disclosures Off Label Use: Obinutuzumab is a type II CD20 monoclonal antibody which is licensed for use in combination with chlorambucil in untreated patients with CLL but is not currently approved for use in follicular lymphoma.. Grigg: Roche: Consultancy. Dreyling: Roche: Honoraria, Research Funding. Rule: Roche: Hon... |
[1]: /lookup/external-ref?link_type=CLINTRIALGOV&access_num=NCT00825149&atom=%2Fbloodjournal%2F124%2F21%2F1743.atomAcoustic Performances of High Insulation Ventilating Windows Integrated with Rolling Shutter Boxes |
High Sound Insulation Ventilating Windows (HSIVW) have been recently proposed for noise control in buildings close to motorways or railways, where noise barriers are not effective or too expensive. These windows are characterized by good insulation performances and at the same time allow airflow through the window itse... |
By constructing a technology spillover connectedness index and connectedness matrix, this paper studies the technology spillover connectedness among innovation agents in China from the perspective of network topology. An empirical study based on invention patent data finds that there is noticeable technology spillover ... |
Biotyper analysis of Nannizziopsis guarroi, a fatal fungal pathogen in lizards, was described recently. Hypocrealean fungal infections in captive reptiles appear with an increasing frequency during the last decade. Therefore, the aim of this study was to proof Matrix-assisted laser desorption ionization-time-of-flight ... |
The plethora of base-mental alloys and metal-free restorations and ever rising cost of palladium alloys has given this full-feature PFM system a definite place in modern dentistry. Thanks to the minimum tooth reduction necessary, GES PureGold has a number of clinical and aesthetic advantages. The system's gold substruc... |
Aim. The article deals with assessing the effect of different types of motor activity performed during physical education classes on myopia development. Materials and methods. 42 female university students aged 18 years participated in the study. All participants are characterized by acquired uncomplicated myopia. Thre... |
This paper presents the characterization and synthesis results for a hardware implementation of a reconfigurable digital logic cancellation circuit auxiliary for multi-mode Σ∆ modulator that is capable to perform the analog-to-digital conversion for GSM, CDMA and WLAN standards. The Σ∆ modulator reconfigures its mash t... |
A new and novel scheme for a high speed all-optical half adder based on single Quantum-dot semiconductor optical amplifier (QD-SOA) assisted Mach-Zehnder interferometer (MZI) is theoretically investigated and discussed. In this proposed scheme, pair of input data streams are simultaneously drive the switch to produce s... |
PCT No. PCT/SU88/00048 Sec. 371 Date Jun. 19, 1989 Sec. 102(e) Date Jun. 19, 1989 PCT Filed Feb. 29, 1988 PCT Pub. No. WO89/05451 PCT Pub. Date Jun. 15, 1989.The scanning device for ultrasonic control of articles comprises a suspension assembly (7) for mounting ultrasonic transducers on a motion mechanism (6) of the sc... |
BACKGROUND |
Elevated plasma levels of very low-density lipoprotein (VLDL) are associated with an increased risk for focal glomerulosclerosis, which is analogous to atherosclerosis. One feature of focal glomerulosclerosis is the presence of foam cells derived from the infiltration of circulating monocytes. Mesangial cells are able ... |
METHODS |
For adhesion studies, mesangial cells isolated from Sprague-Dawley rats were treated with VLDL for six hours, followed by a one-hour incubation with Tamm-Horsfall protein-1 (THP-1) cells. Mesangial MCP-1 mRNA levels were determined by reverse transcription-polymerase chain reaction. MCP-1 protein was determined by soli... |
RESULTS |
VLDL (100 to 300 microg/mL) significantly enhanced the expression and secretion of MCP-1 (54 to 285 ng/well) in mesangial cells. Such an effect was accompanied by the increased adhesion of monocytes to mesangial cells and later the formation of foam cells from monocytes after ingesting excessive amounts of VLDL lipids.... |
CONCLUSIONS |
Our results demonstrate that elevated levels of VLDL, through the action of MCP-1, may contribute to the infiltration of monocytes into the mesangium and subsequent foam cell formation. Hence, VLDLs may play a role in the pathogenesis of focal glomerulosclerosis. One of the mechanisms of such effect may be mediated thr... |
Abstract Minkowski space-time is specified with respect to a single coordinate frame by the set of timelike lines. Isotropy mappings are defined as automorphisms which leave the events of one timelike line invariant. We demonstrate the existence of two special types of isotropy mappings. The first type of isotropy mapp... |
Abstract Nystatin is an antifungal agent used for prophylaxis and treatment of candidiasis, especially oral mycosis. Efficacy of nystatin conventional dosage forms is limited by the short residence time and bitter taste of the drug. This research aims at designing an optimized formulation of oral mucoadhesive gel of ny... |
Untidy issues The performance of third parties. Technically clients of Traidcraft, their producers and suppliers of third world goods, are separate organizations. Traidcraft is not responsible for them. However Traidcraft’s marketing pitch is that it is enabling a better life for these producers. This is the added valu... |
Block cipher systems are widely used in cryptographic applications. The main problem in implementing any block cipher system is the fixed structure of s-boxes elements. In this paper we present a new method to build up dynamic look-up tables (s-boxes) changing with every change of the secret key in addition to an evalu... |
1Common-mode voltage produced by voltage source inverters is of great concern in motor drives because significant amount of common-mode conducted/bearing current is induced and interferes with system operation. As an alternative to inserting bulky passive filters to attenuate common-mode current, a new topology "active... |
Traffic forecasting is one of important functions in Intelligent transportation systems (ITSs) and is of great significance to user experience and urban traffic control. Edge computing, has been recognized as a promising technique for real-time and accurate traffic flow forecasting. In this paper, we propose Spatial-Te... |
As baby boomers age, diabetes mellitus, cancer, osteoarthritis, cardiovascular diseases, and orthopedic disorders are more widespread and the demand for better biomedical devices and functional biomaterials is increasing rapidly. Owing to the good biocompatibility, chemical stability, catalytic efficiency, plasticity, ... |
Scatterometry as a non-imaging indirect optical method in wafer metrology is also relevant to lithography masks designed for extreme ultraviolet lithography, where light with wavelengths in the range of 13 nm is applied. The solution of the inverse problem, i.e. the determination of periodic surface structures regardin... |
This paper presents numerical and experimental investigations of a superabrasive electroplated grinding wheel with a defined CBN grain pattern and a standard superabrasive grinding wheel with a stochastic grain distribution. Concerning the numerical studies, kinematic simulations for different process parameters are pe... |
We conducted this study to identify clinico‐pathologic and prognostic factors that are associated with fatty acid binding protein‐4 (FABP4) and to discuss its therapeutic potentials in patients with breast cancer (BC). In a total of 75 patients with an established diagnosis of invasive ductal carcinoma of the breast, w... |
We present multi-modality visualization strategies to convey information contained in registered Single Photon Emission Photography (SPECT) and Magnetic Resonance (MR) images of the brain. Multi-modality visualization provides a means to retrieve valuable information from the data which might otherwise remain obscured.... |
The article substantiates some prospective indicators of the financial reporting: profitable investments in tangible assets and financial investments, the appearance of which in an organization is a prerequisite for logical sequential operations for recognizing income. The interest of well-known user groups is revealed... |
ABSTRACT Continuous planting of banana disrupts the micro-ecological balance, resulting in severe fusarium wilt disease caused by Fusarium oxysporum f. sp. cubense (FOC). In this study, fifty-eight antagonistic bacterial strains were isolated from the rhizosphere soils in fields with different soil types and cropping h... |
Context Improving meat quality traits such as marbling is a well established breeding objective for many beef producers. More recently, the inclusion of feed efficiency is being considered. The main driving factors being the direct feed cost, as well as consumer concerns related to environmental sustainability of beef ... |
A statewide program in California to detect neural tube and other birth defects may revive enthusiasm for mass prenatal screening. Participation in the program is voluntary, but all expectant mothers are asked to sign a statement of "informed consent/refusal." So far California's program seems to be working well, but q... |
Abstract A simple and sensitive spectrophotometric method was described for the determination of carbaryl in its formulations, fortified water, food grains, polluted water, plant material (cabbage), soil, and biological samples (blood and urine) with the prepared coupling reagents. The method was based on alkaline hydr... |
This paper addresses the relationship between amnesty granted to perpetrators of serious human rights abuses and retributivism. It rebuts arguments advanced by Dan Markel and Lucy Allais in support of their claim that the granting of conditional amnesty—amnesty in exchange for perpetrators’ confessing to, and disclosi... |
One of the recurring and yet repetitively unanticipated challenges is the tug of war between homeowners and their mortgage lender/mortgage service over money. A standard condition of mortgages in the United States is that the borrower must have casualty insurance protecting not just the borrower, but also the bank. Whe... |
In recent years, the use of cleaner fish for biological control of sea lice has increased considerably. Along with this, a number of infectious diseases have emerged. The aim of this study was to investigate the susceptibility of lumpfish (Cyclopterus lumpus) to Betanodavirus since it was detected in asymptomatic wild ... |
Atomic force microscopy (AFM) has been used to investigate the local mechanical and structural properties of microtubules polymerized using guanylyl-alpha-beta-methylene diphosphonate (GMPCPP), a slowly hydrolyzable analogue of guanosine triphosphate. Using a combination of AFM imaging and local force spectroscopy, GMP... |
Confluent cultures of mouse aortic endothelial (END-D) were incubated with either [35S]methionine or 35SO4 2-, and the radiolabelled proteoglycans in media and cell layers were analysed for their hyaluronate-binding activity. The proteoglycan subfraction which bound to hyaluronate accounted for about 18% (media) and 10... |
BACKGROUND AND PURPOSE |
Previous reports have suggested that second branchial cleft cysts (BCCs) appear on sonograms as well-defined, cystic masses with thin walls and posterior enhancement. Previous CT and MR imaging findings, however, have indicated heterogeneity of these masses, and, in our experience, sonography also shows a similar varia... |
METHODS |
The sonograms of 17 adults with second BCCs were reviewed. Only patients with surgical or cytologic evidence of BCCs were included in this study. The features evaluated were the location, internal echogenicity, posterior enhancement, and presence of septa and fistulous tract. |
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