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Capillary liquid chromatography/microelectrospray mass spectrometry has been applied to the detection of deoxyribonucleoside adducts of the food-derived mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) from in vivo sources. Adjustments were made to a previously described methodology such that analyte detection coul... |
This paper presents a way to improve the torque control characteristics of railway vehicle at low speed region using the high frequency injection method. In traction drives, the demanded robustness, which can only be reached with expensive, specially constructed speed sensors, limits the speed quantization (often only ... |
Effects of person- and process-focused feedback, parental lay theories, and prosocial self-concept on children's prosocial behavior were investigated with 143 9- and 10-year-old children who participated in a single session. Parents reported entity (person-focused) and incremental (process-focused) beliefs related to p... |
We developed a new photonic colloidal crystal array based on hydrophobic monomer styrene (St) and hydrophilic monomers acrylic acid (AAc), methacrylic acid (MAc), and itaconic acid (IAc) by free radical emulsion polymerization method. These St/AAc, St/Mac, and St/IAc nanoparticles were characterized with respect to par... |
Interdigitated electrode systems are used in a variety of applications, including electrostatic adhesion technology. They are used as a climbing robot or as industrial grippers allowing the manipulation of flat plates [1] . Recently, this technology has been used with success in the application of electrostatic separat... |
Concentrated, persistent poverty is an enduring scar on the U.S. economic and social landscape. The geographic concentrations of poverty in central cities and remote rural areas strongly suggest that “place matters” in generating and maintaining poverty and that policy should pay attention to places as well as people. ... |
In order to determine whether angiotensin II may influence sympathetically mediated arteriolar constriction in man, we have examined the effect of angiotensin II, infused directly into the left brachial artery of normal subjects, on the reduction in forearm blood flow produced by a lower-body negative pressure (LBNP) o... |
Hyaline (HI) and skein‐like inclusions (SLI) are characteristic of familial and sporadic amyotrophic lateral sclerosis (ALS). The HIs are usually round eosinophilic structures, some of which consist of cores and halos and are called Lewy body‐like HIs. The HIs, composed of various amounts of granule‐associated thick fi... |
This developmental process by which analysts consolidate their professional identities after formal training is a topic which has not been discussed sufficiently in the psychoanalytic literature. The aim of this paper is to elucidate the process of identity formation with particular emphasis on how the 'work ego' of ea... |
A three-electrode scanning ion conductance microscope (SICM) was used to investigate the local current-voltage properties of a single nanopore. In this experimental configuration, the response measured is a function of changes in the resistances involved in the pathways of ion migration. Single-nanopore membranes utili... |
Religious organizations are in evidence, management models varied and are no guarantee of success. Management theories are generalizable to churches, but they are also specifically specific and face challenges (in this they are not unlike profit-making companies). In the Administration, a research on such organizations... |
The existing method of graph-based process model discovery has weaknesses in detecting parallel relationship (XOR, AND, and OR). The algorithm only works on a particular graph structure, so it must be reconfigured when applied to other different structures. To answer this problem, this paper proposes an improved method... |
Changes in the sensitivity of adenylate cyclase and steady‐state levels of cyclic AMP (adenosine 3′,5′‐monophosphate) occur in mammalian brain during ischemic episodes. In our previous investigation with the gerbil model of bilateral ischemia there was an indication that ischemic conditions produced an enhancement of G... |
Abstract The United Nations Framework Conventions on Climate Change (UNFCCC) asks their Parties to submit a National Inventory Report (NIR) for greenhouse gas (GHG) emissions on an annual basis. However, when many countries are quickly growing their economy, resulting in substantial GHG emissions, their inventory repor... |
OBJECTIVE |
Although a common procedure, nasogastric (NG) intubation is also painful and unsatisfactory. Previous studies showed the benefits of local anesthesia in various forms over lubricant jelly alone, but they are rarely used due to their inconvenience and unavailability. The authors conducted a double-blind randomized contr... |
MATERIAL AND METHOD |
Patients who fulfilled the indications for NG intubation were randomized to receive either 10% lidocaine spray or placebo (normal saline) spray to the nostril and throat prior to NG intubation. NG tubes lubricated with 2% lidocaine jelly were then inserted by experienced physicians. Physician, who sprayed, inserted the... |
RESULTS |
Sixty patients were included in the present study. Thirty one randomly received lidocaine spray and 29 received placebo spray. There were more female patients in the lidocaine group (65% vs. 28%, p=0.04), but ages, indications for NG intubation, size of NG tube, and physicians' experience in the procedure were similar ... |
CONCLUSION |
10% lidocaine spray plus 2% lidocaine jelly lubrication was more effective in relieving patients' pain, discomfort, and resulted in higher physicians' satisfaction. There were also no additional side effects as compared to 2% lidocaine jelly lubrication alone. Therefore, it should be recommended for routine application... |
The radiation damage in the optical active media of collider detectors and beamline instrumentation is an outstanding problem. The exposed doses reach unprecedented levels in some current and projected implementations. In order to mitigate this, the development of optical materials with higher radiation resistance is u... |
Accessible online at: www.karger.com/ibe A main thrust of modern journalism, it seems, is to try to worry people. Good news doesn’t sell newspapers and in the absence of catastrophe worrying people is second best to reporting disasters. Fortunately, there are always plenty of pots of worry bubbling quietly away on the ... |
Examples are given of the possibility of obtaining diesel fuel from plants. Tests have shown that the liquid from the trunk of the Brazilian jungle tree, Cobaifera langsdorfii, is virtually pure diesel oil. A hole drilled into the tree collects hydrocarbons from capillaries, ruptured by drilling. An acre of 100 mature ... |
We describe an unusual presentation of a localized form of polyarteritis nodosa (PAN) manifested by acute onset of severe calf pain. Biopsies of the gastrocnemius muscle and fascia revealed an acute necrotizing arteritis with fasciitis. The lumens of affected vessels were occluded by thrombi. PAN localized to calf musc... |
While touch interaction with tabletops is now widely accepted as a very natural and intuitive form of input, only little research has been carried out to understand whether and how it might interfere with our natural ways of gestural communication. This poster presents a study that aims at understanding the importance ... |
Two narratives have emerged to describe recent health care reforms in the United States of America (US) and the United Kingdom (UK). One narrative speaks of revolution, that the adoptions of the Affordable Care Act 2010 (ACA) in the US, and the Health and Social Care Act 2012 (HSCA) in the UK, have resulted in fundamen... |
‘House-wives have, in down-right cold blood, inflicted inhuman tortures to their husbands . . . have a look around our hospitals and the stories would tell themselves’, decries Ruff Wanzie in her December 1965 women’s advice column for the Cameroon Times.1 For evidence, she cites the death of a man bitten by a snake wh... |
The variety of functionals, defined in the basic space () n R D of finitary infinitely differentiable functions and assuming extension on () ( ) t x 1 , () () n R D x functions, is examined in the work. This operation correctness condition and its role in the generalized interpretation of equations of mathem atic... |
AUTHORS’ NOTE: This paper represents the views of the authors and not the official position of the Academy of Health Sciences, the U.S. Army, or any government agency unless so designated by authorized documents. We thank the staffs of the Academy of Health Sciences, U.S. Army, and the Health Care Service Support Activ... |
High angular resolution diffusion imaging (HARDI) improves upon more traditional diffusion tensor imaging (DTI) in its ability to resolve the orientations of crossing and branching neural fibre tracts. The HARDI signals are measured over a spherical shell in q-space, and are usually used as an input to q-ball imaging (... |
Cell‐penetrating peptides (CPPs) are attractive vectors for in vivo and in vitro cellular uptake. Their use is, however, limited by insufficient understanding of their preference for a target cell. Here, a new CPP screening method is presented that uses mRNA display. After incubating the target cell lines, such as huma... |
In this research, the objectives are achieved experimentally and numerically. The experimental works consisting tensile, flexural and torsion tests at room temperature (25 o C) for two materials; tungsten carbide and a novel that was eggshell powder mixing with polyester, to find a mechanical properties (Young's modul... |
The study was carried out to evaluate velocity of development of fibrosis of liver in patients with chronic hepatitis C using laboratory tests. The sampling of 150 patients with chronic hepatitis C were examined to analyze blood serum in phase of reactivation detecting concentration of hyaluronic acid, alpha-fetoprotei... |
The electronic and radio equipment technology has made it possible to communicate by means of hand-held terminals directly via satellite. Networks, in which such a service will be offered, are called Satellite Personal Communication Networks. Several S-PCN operators, e.g. Ellipso, Globalstar, ICO-P, Iridium and Odyssey... |
Abstract An electrostatic field was applied to the GH4169 alloy during ageing, and the defect evolution process and mechanism were investigated using positron annihilation spectroscopy and vacuum inverted pendulum mechanical spectrometer. The results indicated that atomic thermal vibration and vacancy mobility can be i... |
Nowadays, cryptography based on the elliptic curve discrete logarithm problem is widely de ployed. This is due to its advantages compared to traditional asymmetric schemes relying on the hardness of factoring large numbers or of break ing the discrete logarithm problem in finite fields. The NIST curves provide a stan... |
We theoretically and experimentally report on fast self-focusing of light in a photorefractive semiconductor. In these applications, semiconductor materials are very attractive considering their high sensitivity at telecommunication wavelengths (1.55 mum), short response time and memory effect. Photorefractive self- fo... |
The BEAMS (battlefield emission and multiple scattering) model is a 26-stream radiative transfer algorithm for the prediction of diffuse radiance in finite 3D non-uniform aerosol clouds. It has been developed by the US Army Research Laboratory as a visualization tool that satisfies the need for visual simulations to sh... |
OBJECTIVE |
By in silico analysis of colon cancer data from the Cancer Genome Atlas (TCGA) database, we develop a prognostic signature to improve the stratification of high-risk stage II colon cancer patients. |
METHOD |
RNA sequencing (RNA-Seq) data from 187 stage II colon cancer patients was obtained from the TCGA data portal. We excluded cases without a sufficient amount of survival data (n=21), leaving 166 stage II colon cancer patients to be selected for further survival analysis. Differentially expressed lncRNAs and miRNAs were u... |
RESULTS |
The multivariate analysis indicates that 2 lncRNAs (WASIR2 and MIR31HG) and 2 miRNAs (hsa-mir-200a and hsa-mir-155) exhibited an independently significant prognostic value for stage II colon cancer. The 4 lncRNA-miRNA signatures for predicting the overall survival (OS) was constructed with the formula: Risk score=exp W... |
CONCLUSIONS |
These findings indicate that the 4 lncRNA-miRNA prognostic signature could be a marker for survival of stage II colon cancer patients.An open-label, dose-escalating study of Maxy-G34, a novel potent, long-acting Pegylated G-CSF, compared with pegfilgrastim (PF) for the treatment of chemotherapy induced neutropenia (CIN... |
e14500 Background: rhG-CSF reduces the incidence and duration of CIN in patients (pts) receiving myelosuppressive chemotherapy. Maxy-G34 is a recombinant, modified human G-CSF, containing three 5 kD PEG groups. These modifications alter both renal and receptor mediated clearance, leading to a longer half-life and the p... |
METHODS |
The primary efficacy endpoint was duration of severe, Grade 4 neutropenia (G4N) in treatment cycle 1. Adults with high-risk Stage I-IIIa breast cancer eligible for TAC chemotherapy received Maxy-G34 at 10, 30, 45, 60 or 100 μg/kg or the active control PF 6 mg, given sub- cutaneously 24-hours after each dose of TAC for ... |
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