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RESULTS |
In this paper, we present a neural-network-based method to predict if a given mutation increases or decreases the protein thermodynamic stability with respect to the native structure. Using a dataset consisting of 1615 mutations, our predictor correctly classifies >80% of the mutations in the database. On the same task... |
AVAILABILITY |
The server is under construction and will be available at http://www.biocomp.unibo.itTrade, Commodities, and Shipping in the Medieval Mediterranean , by David Jacoby. (Variorum Collected Studies Series) 340 pages, b&w illustrations and maps, notes, index. Brookfield, VT: Ashgate, 1997. $94.95 (Cloth) ISBN 0-86078-620-X |
Western halves (occasionally referred to in this volume) goes back to early Armenian history and in many ways explains the complexities and contradictions of modern Armenian identity, mentality, and outlook. Nonetheless, this is a solid pioneering effort. The Armenian People is the best and most extensive narrative in ... |
This paper studies the buffer insertion algorithm for interconnect centric floorplanning. We develop a buffer insertion algorithm based on single-pair shortest-path algorithm. With the assumption that buffers could be inserted anywhere in dead space, the authors construct a graph which takes geometry grid cells on bord... |
In this paper, we analyze face-to-face negotiation interactions with the goal of predicting the respondent's immediate reaction (i.e., accept or reject) to a negotiation offer. Supported by the theory of social rapport, we focus on mutual behaviors which are defined as nonverbal characteristics that occur due to intera... |
1. Frost resistance (FR) is a fundamental process determining various aspects of plant life. Measurements of FR remain challenging as existing methods are time-and labour-intensive. 2. Here, we test the applicability of foliar summer FR measured via the ‘electrolyte leakage’ approach (FR PEL ), a simple and inexpensive... |
Heat pipe cooled traveling wave reactor (HPTWR) is a newly proposed heat pipe reactor. The HPTWR can achieve the low enrichment of loaded fuel, high power density, and long-term continuous operation for the power supply of decentralized electricity markets. Due to the excellent breeding capability of the HPTWR, the Th... |
The antinociceptive effect of alendronate was studied. The bisphosphonate was i.p. administered and two tests were carried out: acetic acid in mice and formalin test in rats. In the acetic acid test, alendronate induced a dose-dependent antinociceptive effect that was statistically significant for the doses of 10, 20 a... |
It is known that ocular motor dysfunction can be treated by utilizing vision therapy or vision training. However, the question remains on whether binocularly normal persons will have any significant change to their vergence ocular motor system if they go through vision training sessions. This study intends to explore t... |
Objective: This study compares maternal mood, marital satisfaction and infant temperament in 128 mothers admitted to the residential care unit of a parentcraft hospitaland 58 mothers in a demographically matched group. Method: Mothers were recruited from the residential care unit of a parentcraft hospital (Tresillian F... |
The Philippines’ state-sponsored commemoration of 500 years since 1521, dubbed “Victory and Humanity,” was wrought with intrigue and controversy. It failed to adequately weigh the complexity of the Philippine past as it marginalized other narratives. At the same time, the celebration itself was sidelined by attempts of... |
Purpose: Using a multilevel approach, this study analyzed the relationship between ball possession and distance covered at different speed sections: total distance (TD), distance covered between 14.1-21 km·h-1 (MIRD), 21.1-24 km·h-1 (HIRD), and > 24.1 km·h-1 (VHIRD). Methods: The sample included 1,520 matches played by... |
Gastric adenocarcinoma of fundic gland type [chief cell predominant type; (GA-FD-CCP)] is a rare gastric cancer variant arising from non-atrophic mucosa without Helicobacter pylori infection in the upper third portion of the stomach. GA-FD-CCP originates deep in the mucosal layer; hence, endoscopic lesion detection is ... |
Background: In malignant diseases, circulating amino acid profiles correlate with organ sites of malignancy. Direct effects of malignant cells on the extracellular amino acid profile are still uncertain. Methods: Free amino acids were measured in serum-free culture media (RPMI-1640) conditioned by two human pancreatic ... |
Direct infusion-mass spectrometry (DI-MS) currently serves as an alternative analytical tool for metabolomics owing to the unique high throughput advantage. Except the inherent shortcoming at significant matrix effect, there are two other primary technical obstacles dampening its wide applications, such as data alignme... |
Radiation accidents are uncontrolled and ill-defined, the exposure is nonuniform and may be partial body, forecasting a variable dose distribution and sparing of hematopoietic stem cells. We propose that the “best” treatment protocol available now for severely irradiated personnel with acute hematopoietic syndrome is t... |
We present a model of mixed lymphocyte culture (MLC) response which assumes one specificity per locus. It also assumes that an animal A will fail to stimulate animal B if, and only if, the set of specificities possessed by A is a subset of the set of specificities in B. The last assumption implies that non-stimulation ... |
OBJECTIVE |
We examined how combination DMARD therapies and TNF inhibitors therapies plus MTX (TNF/MTX) affect clinical and radiological outcomes compared with MTX monotherapy in early RA. |
METHODS |
We systematically searched EMBASE, PubMed and Ovid Medline for randomized controlled trials (RCTs) of combination therapy in early RA. We evaluated ACR responses, withdrawals for inefficacy and toxicity, HAQ and radiographic progression. Meta-analysis using Review Manager evaluated random effects odds ratios (ORs) and ... |
RESULTS |
A preliminary search identified 2029 citations; 15 were relevant RCTs (4200 randomized patients). Patients with active disease were enrolled. Compared with MTX monotherapy, both combination DMARDs and TNF/MTX increased ACR20-70 responses (OR 1.64-2.02 and 2.03-2.30, respectively), reduced withdrawals for inefficacy (OR... |
CONCLUSIONS |
In early active RA, both combination DMARDs and TNF/MTX are more effective than MTX monotherapy. DMARD and TNF/MTX combinations had equal efficacy on ACR response, withdrawals for inefficacy, disability and erosive progression. There is an apparent advantage for TNF/MTX combinations in the effect on toxicity with fewer... |
1 The effects of exogenous adenine nucleotides and structural analogues on the biphasic insulin response to an increase of glucose concentration in the physiological range (from 4.2 to 8.3 mm) were studied in the isolated perfused rat pancreas. Purinoceptor agonists were added either simultaneously or 15 min before inc... |
Internet service providers (ISPs) depend on one another to provide global network services. However, the profit-seeking nature of the ISPs leads to selfish behaviors that result in inefficiencies and disputes in the network. This concern is at the heart of the “network neutrality” debate, which also asks for an appropr... |
This investigation shows that there are four relevant methods of telephoning in Denmark for hearing-impaired persons: 1) Standard telephone without extra equipment for persons with a Speech Reception Threshold (SRT) up to about 40 dB in the better ear. 2) Standard telephone with receiving amplifier for persons with a S... |
Abstract In biological systems, the Keap1/Nrf2/antioxidant response element pathway determines the ability of mammalian cells to adapt and survive conditions of oxidative, electrophilic and inflammatory stress by regulating the production of cytoprotective enzymes NAD(P)H:quinone oxidoreductase 1 (NQO1, EC 1.6.99.2) be... |
Organisational justice has been identified as the glue that allows people to work together effectively. The increasing electronic monitoring and surveillance of workers that has emerged in the 21st century may be conceived as a continuation of former practices – indicated in words like ‘supervisor’ and ‘overseer’, with... |
Inflammation may play a role in increased risk of heart failure (HF) that is associated with obesity, metabolic syndrome (MS), and diabetes. This study investigated associations between inflammatory markers, MS, and incident HF in a population with a high prevalence of diabetes, obesity, and MS. The cohort consisted of... |
Background Socioeconomic inequalities in cardiovascular disease are stronger and more consistent in females compared with males. However, mechanisms underlying these inequalities and whether they emerge in early life are unclear. Methods Trajectories of 148 metabolic trait concentrations from age 7y to 25y in a contemp... |
The literature on Hospital Supply Chain performance is limited and assessing the performance of the Hospital Supply Chain (HSC) is currently a key challenge. The sector has to balance the seemingly incompatible demand of cost reduction and quality improvement. Despite hospital supply chain having a great impact on hosp... |
The development of digitized humanity information provides a new perspective on data-oriented studies of history. Many previous studies have ignored uncertainty in the exploration of historical figures and events, which has limited the capability of researchers to capture complex processes associated with historical ph... |
Objectives: The object of this study is to evaluate clinical, biochemical and ultrasonographyic findings in early diagnosis of Dengue Hemorrhagic Fever (DHF). Design: A case series. Place study: The study was carried out in Medical Department of CMH and Mayo Hospital, Lahore. Methodology: 351 patients suspected of DHF ... |
The purpose of the article is a realization of organic character to the lyrical concept of piano concerto in the French tradition, presented Concerto С.Saint-Saёns, actual intonation expressiveness which is determined "nеоcymbolism" (on E.Markova) to pоstvаnguard in music and "nео-Gоthic in art" in Ukrainian refraction... |
We experimentally explore the motion of falling spheres in strongly stratified fluids in which the fluid transitions from low density at the top to high density at the bottom and document an internal splash in which the falling sphere may reverse its direction of motion (from falling, to rising, to falling again) as it... |
The past decade has seen the explosion of experimental results on nanowires grown by catalyzed mechanisms. However, few are known on their electronic properties especially the influence of surfaces and catalysts. We demonstrate by an optical method how a curious electron-hole thermodynamic phase can help to characteriz... |
One of the two evening lectures at the jubilee meeting of the British Association for the Advancement of Science in 1881 was delivered by the printer, stationer, mathematician, and electrical experimenter William Spottiswoode. The meeting marked the triumphant return of the British Association for the Advancement of Sc... |
The subject of this research is examination of the activity of the Soviet pedagogues in teaching foreign students based on the materials of the Mongolian worker’s faculty. The object of this research is the Soviet-Mongolian cooperation in educational sphere that developed in the 1920s – 1930s. The Mongolian worker’s f... |
Evaluation of the Flinders Technology Associates Cards for Storage and Temperature Challenges in Field Conditions for Foot-and-Mouth Disease Virus Surveillance. |
Foot-and-mouth disease virus (FMDV) samples transported to the laboratory from far and inaccessible areas for diagnosis and identification of FMDV pose a major problem in a tropical country like India, where wide fluctuation of temperature over a large geographical area is common. Inadequate storage methods lead to spo... |
Cross talk is the key factor in determining the quality of stereoscopic television image. There is no normal distribution law of the stereoscopic television image cross talk value, so the traditional black and white image signal is not suitable for this 3DTV cross talk test. in this paper, we select a few points as the... |
“The Neely Conference: Developing Research Criteria to Define Medical Necessity in EMS” convened emergency medical services (EMS) physicians, researchers, administrators, providers, and federal agency representatives to begin the development of a set of uniform triage criteria and outcome measures that could be used to... |
Chronic venous stasis is an extremely complex clinical syndrome of pain and changes in the skin that can involve the superficial, deep, and perforating veins. This syndrome is commonly referred to as "the postphlebitic syndrome," implying that thrombophlebitis is its sole etiology. To test this hypothesis, we performed... |
If human beings care about their relative weight, a form of imitative obesity can emerge (in which people subconsciously keep up with the weight of the Joneses). Using Eurobarometer data on 29 countries, this paper provides cross-sectional evidence that overweight perceptions and dieting are influenced by a person's re... |
Digital competences are part of the profile of the educational professional in virtual situations. Better development of these capacities is assumed in emerging virtual education systems due to the educational models that emerged in a pandemic. The objective of the research was to analyze the digital competences in rem... |
We present dust color temperature, dust mass and Planck function distributions in the two far infrared cavities located within 0.25 of white dwarfs WD0038+730 and WD0531-022. For this, IRAS (Infrared Astronomical Satellite) data at longer wavelengths (60 and 100 mm) have been used. The dust color temperature is found t... |
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