text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
cholera toxin in the presence of gtp increased adenylate cyclase activity in a purified bovine thyroid plasma membrane preparation , whereas , in the presence of guanosine 5'- ( beta , gamma-imido ) -triphosphate ( gpp ( nh ) p ) , cholera toxin had no stimulatory effect . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
33,
36
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
215,
227
]
} |
similarly , prostaglandin e1 enhanced the adenylate cyclase activity induced by gtp but not by gpp ( nh ) p . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
80,
83
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
95,
107
]
} |
( 1 ) cholera toxin and prostaglandin e1 enhance thyroid adenylate cyclase activation by gtp ( or itp ) , but have no stimulatory effect on the gpp ( nh ) p ( or ipp ( nh ) p ) response ; | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
89,
92
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
144,
156
]
} |
( 2 ) the stimulatory effect of prostaglandin e1 on adenylate cyclase may result from decreased affinity for gdp at the guanine nucleotide regulatory site ; | NA | {
"id": "C0018340",
"name": "gdp",
"pos": [
109,
112
]
} | {
"id": "C0018328",
"name": "guanine",
"pos": [
120,
127
]
} |
the effect of a temperature shift from low ( 36 degrees c ) to high ( 40 degrees c ) temperature on human fibroblasts ( imr90 ) at various population doubling levels and imr90 cells transformed by sv40 virus infection at a population doubling level of 30 ( sv40/imr90 ) was examined . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
176,
181
]
} |
the basal 32p-labelling of phospholipids including phosphatidic acid , phosphatidylinositol , phosphatidylcholine , phosphatidylethanolamine and the polyphosphoinositides increased with na+ concentration [ 2 ] . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
71,
91
]
} | {
"id": "C0071655",
"name": "polyphosphoinositides",
"pos": [
149,
170
]
} |
we have investigated the nuclear protein matrix ( npm ) in the rabbit blood granulocyte and its precursor cells to determine ( a ) whether the npm composition is similar to other cells that have been studied and ( b ) to determine whether the dramatic morphological changes that the granulocyte nucleus undergoes during cell maturation are related to changes in the composition or structure of the npm . | NA | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
96,
111
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
179,
184
]
} |
the incidence of low and suboptimal birth weight was highest in first , fifth , and subsequent births , and conversely optimal weight was commonest in second , third , and fourth births . | NA | {
"id": "C0005612",
"name": "birth weight",
"pos": [
36,
48
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
127,
133
]
} |
data are presented on the quantitative distribution of individual catecholamines , noradrenaline ( na ) , dopamine ( da ) and adrenaline ( a ) determined within specific microdissected areas of the third thoracic segment of the cat spinal cord , using a radioenzymatic assay . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
83,
96
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
126,
136
]
} |
the use of galactose oxidase ( ec 1.1.3.9 ) and tritiated sodium borohydride for labeling of membrane glycoproteins , described by gahmberg and hakomori , has previously been applied to the study of myelin glycoproteins of experimental animals . | NA | {
"id": "C0025248",
"name": "membrane glycoproteins",
"pos": [
93,
115
]
} | {
"id": "C0129439",
"name": "myelin glycoproteins",
"pos": [
199,
219
]
} |
contribution of noradrenaline- , dopamine- and adrenaline-containing axons to the innervation of different regions of the spinal cord of the cat . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
16,
29
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
47,
57
]
} |
the quantitative distributions of noradrenaline ( na ) , dopamine ( da ) and adrenaline ( a ) were estimated throughout the grey and white matter at various levels of the cat spinal cord ( c5 , t3 , t10 and l2 ) . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
34,
47
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
77,
87
]
} |
fractionation of [ 35s ] methionine-labeled synaptic membranes by lectin affinity chromatography and analysis of [ 3h ] fucose labeling patterns indicated that , in contrast to the general reduction in labeling of brain proteins , the synthesis of synaptic glycoproteins was not altered by lsd . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
66,
72
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
262,
270
]
} |
rabbit anti-human fibronectin specifically labeled fibroblasts which comprised less than 5 % of the cell population , but did not bind to schwann cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
146,
150
]
} |
superfusion with yohimbine , isoprenaline , salbutamol or tazolol increased , while superfusion with propranolol decreased , the release of all three catecholamines . | NA | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
29,
41
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
150,
164
]
} |
the nrc is amending its regulations to permit licensees greater leeway in disposing of liquid scintillation media and animal carcasses containing tracer levels of hydrogen-3 ( tritium ) or carbon-14 . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
163,
171
]
} | {
"id": "C0041119",
"name": "tritium",
"pos": [
176,
183
]
} |
renal failure secondary to oxalate interstitial nephritis developed in three patients with malabsorption and steatorrhea following a jejunoileal bypass , extensive small intestine resection and a partial gastrectomy . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
91,
104
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
109,
120
]
} |
this report shows that it can also occur in patients with other bowel disorders that cause malabsorption and steatorrhea . | NA | {
"id": "C0021831",
"name": "bowel disorders",
"pos": [
64,
79
]
} | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
91,
104
]
} |
this report shows that it can also occur in patients with other bowel disorders that cause malabsorption and steatorrhea . | NA | {
"id": "C0024523",
"name": "malabsorption",
"pos": [
91,
104
]
} | {
"id": "C0038238",
"name": "steatorrhea",
"pos": [
109,
120
]
} |
this family study thus suggests that individuals with the fz phenotype are at risk for pulmonary emphysema and chronic obstructive airways disease , particularly in the presence of other risk factors , such as cigarette smoking and grain dust exposure . | NA | {
"id": "C0034067",
"name": "pulmonary",
"pos": [
87,
96
]
} | {
"id": "C0024117",
"name": "chronic obstructive airways disease",
"pos": [
111,
146
]
} |
clinical dextran derivatives in which from 5 to 50 % of the d-glucose units were oxidized acted as potent and specific enzyme-inhibitors , as did 10 % -oxidized derivatives of dextran fractions ranging in mol . wt . from 10 ( 4 ) to 2 x 10 ( 6 ) . | NA | {
"id": "C0011806",
"name": "dextran derivatives",
"pos": [
9,
28
]
} | {
"id": "C0086140",
"name": "dextran",
"pos": [
176,
183
]
} |
in contrast , periodate oxidation of ( 1 leads to 6 ) -alpha , ( 1 leads to 3 ) -alpha- , and ( 1 leads to 4 ) -alpha-linked oligosaccharides containing less than approximately 15 d-glucose units , and of sucrose and structurally related trisaccharides , yielded derivatives that were poor inhibitors . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
125,
141
]
} | {
"id": "C0041102",
"name": "trisaccharides",
"pos": [
238,
252
]
} |
immunohistochemical specificity test have shown this immunoreactive substance to belong to the gastrin group , sharing an antigenic determinant with cholecystokinin ( cck ) and pentagastrin ( common amino-acid sequence trp-met-asp-phe ) . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
95,
102
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
177,
189
]
} |
this rdna consists of 11 kb linear double-stranded dna molecules , each containing a single rrna gene copy . | NA | {
"id": "C0012933",
"name": "rdna",
"pos": [
5,
9
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
35,
54
]
} |
the axonal transport of two soluble enzymes of intermediary metabolism was evaluated : the nerve-specific form of the glycolytic enzyme enolase ( nse ) and the brain isozyme of creatine phosphokinase ( cpk ) . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
36,
42
]
} | {
"id": "C0022173",
"name": "isozyme",
"pos": [
166,
173
]
} |
the extracts were added to carcinomatous ( hela ) or to non-carcinomatous cells ( mrc5 fibroblasts or foetal human lung cells ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
74,
79
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
87,
98
]
} |
torsades de pointes spontaneously progressed to ventricular tachycardia with a uniform morphology in three patients and to ventricular fibrillation in four . | NA | {
"id": "C0040479",
"name": "torsades de pointes",
"pos": [
0,
19
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
48,
71
]
} |
our data suggest that torsades de pointes in this setting may be a rapid reentrant ventricular tachycardia closely related to recurrent sustained ventricular tachycardia and a precursor to ventricular fibrillation and sudden death . | NA | {
"id": "C0040479",
"name": "torsades de pointes",
"pos": [
22,
41
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
146,
169
]
} |
the choline formed in each instance is enzymically phosphorylated with [ gamma-32p ] atp to yield [ gamma-32p ] phosphorylcholine , which is isolated by anion-exchange chromatography and shown to be stoichiometrically related to lecithin , lysolecithin , and sphingomyelin . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
4,
11
]
} | {
"id": "C0031716",
"name": "phosphorylcholine",
"pos": [
112,
129
]
} |
transamination of branched-chain amino acids to ( alpha-oxoglutarate , catalyzed by leucine aminotransferase coupled to the glutamate dehydrogenase reaction , is used in an enzymic assay for determination of branched-chain amino acids in serum and tissue homogenates . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
18,
44
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
223,
234
]
} |
the specificity of the substrate for kallikrein was demonstrated by using plasma deficient in prekallikrein ( fletcher trait ) diluted with pooled normal human plasma . | NA | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
37,
47
]
} | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
94,
107
]
} |
reagents known to increase or decrease the yields of superoxide , peroxide or hydroxyl radicals have no effect on the photodamage . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
53,
63
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
66,
74
]
} |
by a combination of radioenzymatic assay and paper chromatography the concentrations of adrenaline , noradrenaline , dopamine , alpha-methylnoradrenaline and alpha-methyldopamine were determined concurrently in the same sample . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
88,
98
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
140,
153
]
} |
by a combination of radioenzymatic assay and paper chromatography the concentrations of adrenaline , noradrenaline , dopamine , alpha-methylnoradrenaline and alpha-methyldopamine were determined concurrently in the same sample . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
101,
114
]
} | {
"id": "C0025805",
"name": "alpha-methylnoradrenaline",
"pos": [
128,
153
]
} |
a differential displacement of the parent catecholamines was observed and the depletions were ranked : adrenaline less than dopamine less than noradrenaline . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
103,
113
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
143,
156
]
} |
clofibric acid disposition was studied in four healthy men after 1 wk of clofibrate ingestion ( 500 mg orally every 12 hr ) with and without probenecid ( 500 mg orally every 6 hr ) . | NA | {
"id": "C0009003",
"name": "clofibric acid",
"pos": [
0,
14
]
} | {
"id": "C0009002",
"name": "clofibrate",
"pos": [
73,
83
]
} |
the distributions of the highly abundant families of dna ( satellite dnas ) between the autosomes , sex chromosomes and b chromosomes of g.m . morsitans , g. austeni and g. pallidipes have been examined by in situ hybridisation . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
53,
56
]
} | {
"id": "C0012934",
"name": "satellite dnas",
"pos": [
59,
73
]
} |
to address these questions , the relationship between plasma aldosterone ( pa ) and prl responses to 2 different dopamine receptor antagonists , haloperidol and metoclopramide ( mcp ) was examined in rats . | NA | {
"id": "C2917388",
"name": "2",
"pos": [
101,
102
]
} | {
"id": "C0025853",
"name": "metoclopramide",
"pos": [
161,
175
]
} |
anti-insulin ige had a higher avidity for bovine compared with porcine insulin in both groups . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
5,
12
]
} | {
"id": "C0724601",
"name": "porcine insulin",
"pos": [
63,
78
]
} |
induction of metabolism probably does not play a part in this interaction because antipyrine half-lives and urinary d-glucaric acid excretion were not altered by chronic administration of sodium valproate to 8 patients receiving this drug alone . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
13,
23
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
132,
141
]
} |
it was found in 22 hospitalized epileptic patients taking dph , primidone , and phenobarbital as a combined therapy that the number of side effects per patient could be correlated only with the serum levels of dph . | NA | {
"id": "C0033148",
"name": "primidone",
"pos": [
64,
73
]
} | {
"id": "C0031412",
"name": "phenobarbital",
"pos": [
80,
93
]
} |
the correlation between seizures and menstrual cycle was studied in 69 females with epilepsy , mean age 28.7 years . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
24,
32
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
84,
92
]
} |
in the group of women with seizures related to menstrual cycle the course of epilepsy was worse , the premenstrual tension syndrome was present more often and cycles were prolonged as compared with females without correlation between seizures and cycle . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
77,
85
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
234,
242
]
} |
the great interest in new compounds able to increase gaba concentration in the brain as potential antiepileptic drugs has led to the synthesis of powerful inhibitors of gaba transaminase ( gaba-t ) e.g . gamma-acetylenic gaba ( gag ) and gamma-vinyl-gaba . | NA | {
"id": "C0016904",
"name": "gaba",
"pos": [
53,
57
]
} | {
"id": "C0048044",
"name": "gamma-vinyl-gaba",
"pos": [
238,
254
]
} |
the data therefore suggest that the glomerular epithelial cells synthesize and secret both sulfated gag ( heparan sulfate ) and nonsulfated gag ( hyaluronic acid ) into the culture medium , whereas the glomerular mesangial cells synthesize and secrete nonsulfated gag ( hyaluronic acid ) only into the culture medium . | NA | {
"id": "C0019143",
"name": "heparan",
"pos": [
106,
113
]
} | {
"id": "C0017973",
"name": "gag",
"pos": [
264,
267
]
} |
they exhibited ratios of 3- to 4-hydroxyproline , of total hydroxyproline to proline , and of hydroxylysine to lysine characteristic of type iv procollagen . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
33,
47
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
77,
84
]
} |
the model for the glomerular filter presented here is based on the relationship between basement membrane collagen and fibrillar collagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
106,
114
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
119,
137
]
} |
the glomerular basement membrane collagen is produced by the epithelial cell and present on its surface in a staggered organization as in fibrillar collagen . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
33,
41
]
} | {
"id": "C0969669",
"name": "fibrillar collagen",
"pos": [
138,
156
]
} |
these results suggested that the glomerular lesions induced by the two antisera were due to anticollagen antibodies while the tubulointerstitial lesions were due to antibodies directed against the noncollagenous portion of tbm . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
71,
79
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
165,
175
]
} |
although the residue was more polar than whole gbm it still contained significant amounts of glycine and hydroxyproline and could be further subfractionated with sds into a soluble fraction , the amino acid content of which was similar to whole gbm and a collagenous residue containing 317 residues/1,000 of glycine . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
196,
201
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
308,
315
]
} |
an increase in the hydroxylated amino acid content was found in gbm prepared from su fed rats and the glycine content was also higher . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
32,
42
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
102,
109
]
} |
the feeding of su diets provides a useful animal model with which to study the effect of dietary carbohydrate on renal gbm . | NA | {
"id": "C0376597",
"name": "su diets",
"pos": [
15,
23
]
} | {
"id": "C0012170",
"name": "dietary",
"pos": [
89,
96
]
} |
insulin analogues were less potent than insulin itself in inhibiting the binding of 125i-insulin to both glomeruli and tubules in the order of relative potency : insulin greater than despentapeptide insulin greater than proinsulin indicating the specificity of the binding . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
220,
230
]
} |
the carcinogenicity of quercetin , a flavonol , was tested in six-week-old ddy mice of both sexes . | NA | {
"id": "C0034392",
"name": "quercetin",
"pos": [
23,
32
]
} | {
"id": "C0060444",
"name": "flavonol",
"pos": [
37,
45
]
} |
an isolated liver perfusion system was used as a simplifying tool to study the metabolism and excretion of benzo ( alpha ) pyrene ( bp ) as a prototype carcinogen/mutagen . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
79,
89
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
94,
103
]
} |
glycosylated hemoglobins are minor components of human red cell hemoglobin , structurally , they are closely related to adult hemoglobin and are formed nonenzymatically by condensation of glucose or other reducing sugars with hemoglobin a . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
13,
23
]
} | {
"id": "C0019016",
"name": "hemoglobin a",
"pos": [
226,
238
]
} |
increased flexibility or distortion of the hemoglobin molecule allows more ready oxidation to methemoglobin but , more importantly , there is also rapid conversion of methemoglobin to hemichrome with resultant denaturation and precipitation . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
43,
53
]
} | {
"id": "C0025635",
"name": "methemoglobin",
"pos": [
167,
180
]
} |
pregnancy associated with chronic nephritis has to be interrupted in the first trimester as the particular conditions of pregnancy predispose to pyelonephritis . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
0,
9
]
} | {
"id": "C0032979",
"name": "first",
"pos": [
73,
78
]
} |
testosterone and medroxyprogesterone acetate were active inducers , d/1 norgestrel was less active , while epitestosterone , estradiol , and progesterone were ineffective . | NA | {
"id": "C0039601",
"name": "testosterone",
"pos": [
0,
12
]
} | {
"id": "C0014594",
"name": "epitestosterone",
"pos": [
107,
122
]
} |
the purpose of this study was to examine the effects of natural cannabinoids - including delta-9-tetrahydrocannabinol ( thc ) , cannabinol ( cbn ) , and cannabidiol ( cbd ) - on chromosome segregation . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
64,
76
]
} | {
"id": "C0039663",
"name": "delta-9-tetrahydrocannabinol",
"pos": [
89,
117
]
} |
the purpose of this study was to examine the effects of natural cannabinoids - including delta-9-tetrahydrocannabinol ( thc ) , cannabinol ( cbn ) , and cannabidiol ( cbd ) - on chromosome segregation . | NA | {
"id": "C0006864",
"name": "cannabinoids",
"pos": [
64,
76
]
} | {
"id": "C0006865",
"name": "cbn",
"pos": [
141,
144
]
} |
thirty-eight patients with ocular hypertension or glaucoma were treated with topical timolol for 12-30 months ( mean 20 ) . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
27,
46
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
50,
58
]
} |
thirty-eight patients suffering from recurrent affective disorder were treated at the lithium clinic of the department of clinical psychiatry , university of florence , with lithium carbonate for a period of 3-8 years ; | NA | {
"id": "C0023870",
"name": "lithium",
"pos": [
86,
93
]
} | {
"id": "C0085217",
"name": "lithium carbonate",
"pos": [
174,
191
]
} |
because of its almost iso-ionic composition the authors prefer the 153-electrolyte solution to isotonic saline . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
26,
31
]
} | {
"id": "C0013832",
"name": "electrolyte",
"pos": [
71,
82
]
} |
biochemical blood analyses and serological investigations with respect to infectious and parasitic disease were also systematically undertaken . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
74,
84
]
} | {
"id": "C0030499",
"name": "parasitic disease",
"pos": [
89,
106
]
} |
-- all strains tested were sensitive to the nitrofurans and related compounds ( furazolidone , nitrovin ) , flavomycin , carbadox , trimethoprim , rifamycin and the virginiamycin combination . | NA | {
"id": "C0028155",
"name": "nitrofurans",
"pos": [
44,
55
]
} | {
"id": "C0016855",
"name": "furazolidone",
"pos": [
80,
92
]
} |
-- all strains tested were sensitive to the nitrofurans and related compounds ( furazolidone , nitrovin ) , flavomycin , carbadox , trimethoprim , rifamycin and the virginiamycin combination . | NA | {
"id": "C0028155",
"name": "nitrofurans",
"pos": [
44,
55
]
} | {
"id": "C0028216",
"name": "nitrovin",
"pos": [
95,
103
]
} |
seizures and epilepsy in a mentally retarded population over the first 22 years of life . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
0,
8
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
13,
21
]
} |
the inhibition of rf latex agglutination detects those immune complexes which contain immunoglobulins g as antibodies . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
55,
71
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
107,
117
]
} |
it seems that there are no essential changes in hemostasis of term infant , but many coagulation factors exhibit deficient clotting activity as like vitamin k-dependent factors ( ii , vii , ix , x ) . | NA | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
85,
104
]
} | {
"id": "C0015491",
"name": "ix",
"pos": [
190,
192
]
} |
the recovery of erythroid committed percursor cells and pluripotent haemopoietic stem cells ( cfu-s ) was determined in polycythaemic mice treated with cyclophosphamide ( cy ) . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
46,
51
]
} | {
"id": "C0018956",
"name": "haemopoietic",
"pos": [
68,
80
]
} |
pyruvate and palmitate oxidations by cultured fibroblast suspensions were measured in optimized conditions and proved to be within normal range in the cells from friedreich 's patients . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
46,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
151,
156
]
} |
the potency of those antibiotics tested appears to be as follows : gentamicin greater than streptomycin greater than amikacin greater than sisomicin greater than kanamycin = tobramycin greater than kanendomycin = dibekacin . | NA | {
"id": "C0017436",
"name": "gentamicin",
"pos": [
67,
77
]
} | {
"id": "C0037209",
"name": "sisomicin",
"pos": [
139,
148
]
} |
the potency of those antibiotics tested appears to be as follows : gentamicin greater than streptomycin greater than amikacin greater than sisomicin greater than kanamycin = tobramycin greater than kanendomycin = dibekacin . | NA | {
"id": "C0002499",
"name": "amikacin",
"pos": [
117,
125
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
162,
171
]
} |
the potency of those antibiotics tested appears to be as follows : gentamicin greater than streptomycin greater than amikacin greater than sisomicin greater than kanamycin = tobramycin greater than kanendomycin = dibekacin . | NA | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
162,
171
]
} | {
"id": "C0012024",
"name": "dibekacin",
"pos": [
213,
222
]
} |
glutethimide , its metabolite glutaconimide , and congeners including those with anti-convulsant activity , 4-hydroxyglutaconimide and 4-aminoglutethimide , have all demonstrated concentration-dependent inhibition of corticosterone production by isolated rat adrenal cells . | NA | {
"id": "C0017845",
"name": "glutethimide",
"pos": [
0,
12
]
} | {
"id": "C0002555",
"name": "aminoglutethimide",
"pos": [
137,
154
]
} |
this assay procedure has been used to monitor simultaneously the plasma levels of neostigmine ( 4.7 to 33 ng per ml ) and pyridostigmine ( 2.7 to 18.6 ng per ml ) of a myasthenic patient over a period of twelve hours with repeated dosing of neostigmine bromide ( 30 mg ) and pyridostigmine bromide ( 60 mg ) . | NA | {
"id": "C0027679",
"name": "neostigmine",
"pos": [
82,
93
]
} | {
"id": "C0282261",
"name": "neostigmine bromide",
"pos": [
241,
260
]
} |
this assay procedure has been used to monitor simultaneously the plasma levels of neostigmine ( 4.7 to 33 ng per ml ) and pyridostigmine ( 2.7 to 18.6 ng per ml ) of a myasthenic patient over a period of twelve hours with repeated dosing of neostigmine bromide ( 30 mg ) and pyridostigmine bromide ( 60 mg ) . | NA | {
"id": "C0034261",
"name": "pyridostigmine",
"pos": [
122,
136
]
} | {
"id": "C0034262",
"name": "pyridostigmine bromide",
"pos": [
275,
297
]
} |
the mutant protein behaves identically to the wild-type protein with regard to elution position on various chromatographic columns , and both have similar molecular weights of about 50000 . | NA | {
"id": "C1564139",
"name": "mutant protein",
"pos": [
4,
18
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
56,
63
]
} |
rna-protein interactions in the 80-s rat liver ribosomes were studied by measuring cross-linking of proteins to rrnas induced by ultraviolet radiation , as already reported for free 40-s and 60-s subunits . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
0,
3
]
} | {
"id": "C0035701",
"name": "rrnas",
"pos": [
112,
117
]
} |
evaluation of the selectivity of alpha-adrenoreceptor blocking drugs for postsynaptic alpha 1- and alpha 2-adrenoreceptors in a simple animal model . | NA | {
"id": "C0034784",
"name": "alpha-adrenoreceptor",
"pos": [
33,
53
]
} | {
"id": "C0001639",
"name": "alpha 2-adrenoreceptors",
"pos": [
99,
122
]
} |
the effects of sulfur dioxide ( so2 ) are largely confined to the upper airways except during exercise or if the gas is taken up by a carrier aerosol . | NA | {
"id": "C0038777",
"name": "so2",
"pos": [
32,
35
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
113,
116
]
} |
inactivation of this effect by deoxyribonuclease indicated that the active nucleic acid moiety was dna . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
75,
87
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
99,
102
]
} |
white reports of paraneoplastic syndrome associated with plc abound from the western world -- a geographic area of low incidence of the tumour -- there is a paucity of information from the african continent generally , and specifically from nigeria . | NA | {
"id": "C0030472",
"name": "paraneoplastic",
"pos": [
17,
31
]
} | {
"id": "C0027651",
"name": "tumour",
"pos": [
136,
142
]
} |
[ the kleihauer test and directed prevention of hemolytic disease of the newborn caused by materno-fetal rh isoimmunization ] . | NA | {
"id": "C0014761",
"name": "of hemolytic disease",
"pos": [
45,
65
]
} | {
"id": "C0035404",
"name": "rh isoimmunization",
"pos": [
105,
123
]
} |
they provide about 1/4 of the lymphoreticular proliferations of the skin , a frequency which is comparable with that of cutaneous t-cell-lymphomas ( mycosis fungoides and sezary 's syndrome ) . | NA | {
"id": "C0079773",
"name": "of cutaneous t-cell-lymphomas",
"pos": [
117,
146
]
} | {
"id": "C0036920",
"name": "sezary 's syndrome",
"pos": [
171,
189
]
} |
the fatty acid composition of total lipids , triglycerides , free fatty acid pool , esterified cholesterol , phosphatidyl choline , and phosphatidyl ethanolamine of mammary tissue of lactating and nonlactating buffalo has been studied . | NA | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
4,
14
]
} | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
61,
76
]
} |
the distribution of long chain triglycerides , free fatty acids free cholesterol and esterified cholesterol in nonlactating mammary tissue was 76.1,4.2,4 and 0.5 percent of total lipids respectively and in lactating mammary tissue it was 68.3 , 1.2 , 2.7 and 0.3 percent respectively . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
69,
80
]
} | {
"id": "C0008387",
"name": "esterified cholesterol",
"pos": [
85,
107
]
} |
interferon treatment did not alter the steady-state level of intracellular viral rna as determined by hybridization of total cellular and polysomal poly ( a ) containing rna with mouse mammary tumor virus complementary dna . | NA | {
"id": "C0035736",
"name": "viral rna",
"pos": [
75,
84
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
170,
173
]
} |
evidence has accumulated that a woman 's weight before pregnancy and the weight gained during pregnancy directly affect infant birth weight , incidence of neonatal mortality , and growth and development of the infant during the first year of life . | NA | {
"id": "C0005910",
"name": "weight",
"pos": [
41,
47
]
} | {
"id": "C0005612",
"name": "infant birth weight",
"pos": [
120,
139
]
} |
we have used this lysed cell system in conjunction with nuclease digestion experiments to determine which specific nucleic acids ( dna or rna ) are involved in either the structure and/or microtubule-initiating capacity of kinetochores and centrosomes . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
115,
128
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
131,
134
]
} |
both rnase t1 and rnase a specifically attacked the amorphous pericentriolar material of the centrosomes , with a concomitant loss in the ability of this material to nucleate microtubule formation . | NA | {
"id": "C0018364",
"name": "rnase t1",
"pos": [
5,
13
]
} | {
"id": "C0014241",
"name": "rnase",
"pos": [
18,
23
]
} |
thus , the increase of net absorption during shell calcification was not due to enhanced mucosal capacity for calcium translocation , but rather to a better solubilization of calcium carbonate in the upper digestive tract . | NA | {
"id": "C0006675",
"name": "calcium",
"pos": [
110,
117
]
} | {
"id": "C0006681",
"name": "calcium carbonate",
"pos": [
175,
192
]
} |
this response was of the same magnitude as the reduction in pentagastrin-stimulated acid output , ( ii ) a marked increase in food-induced gastrin release , suggesting a relationship between antral gastrin release and fundal vagal innervation since antral ph remained constant and the amount of protein and the distension volume within the antrum were the same as before proximal vagotomy , ( iii ) a slowing down of the initial phase of gastric emptying of the liquid protein meal in 5 patients , a slight acceleration in 4 and no change in 2 . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
60,
72
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
198,
205
]
} |
various amino acids and guanidines ( l-lysine , l-aspartic and l-glutamic acids , creatine , taurocyamine and glycocyamine ) , studied in ileal ligated loops , increased intestinal calcium absorption in the rat . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
8,
19
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
82,
90
]
} |
dietary cholesterol was absorbed in the second as well as in the first half of the intestine , while the proportions of micellar cholesterol decreased continuously from the jejunum to the ileum . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
0,
19
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
129,
140
]
} |
electrophoretic analysis of rna labelled for 2 hrs at various times during regeneration shows that the product formed during the first phase of regeneration is mainly rrna and low molecular weight rna . | NA | {
"id": "C0035701",
"name": "rrna",
"pos": [
167,
171
]
} | {
"id": "C0035668",
"name": "rna",
"pos": [
197,
200
]
} |
in addition , human bpa increased the relative proportion of fetal hemoglobin in the hemoglobins synthesized by adult circulating bfu-e . | NA | {
"id": "C0015936",
"name": "fetal hemoglobin",
"pos": [
61,
77
]
} | {
"id": "C0019046",
"name": "hemoglobins",
"pos": [
85,
96
]
} |
there was no statistical difference in growth control of the experimental tumor when the electrotherapy was given after the half-life of the tumor was achieved . | NA | {
"id": "C0027659",
"name": "experimental tumor",
"pos": [
61,
79
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
141,
146
]
} |
2 the cyclic nucleotide phosphodiesterase inhibitors , theophylline , papaverine , quinine and 3-isobutyl-1-methylxanthine ( ibmx ) , all acted as vasodilators . | NA | {
"id": "C0039771",
"name": "theophylline",
"pos": [
55,
67
]
} | {
"id": "C0000096",
"name": "3-isobutyl-1-methylxanthine",
"pos": [
95,
122
]
} |
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