text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
dopamine can be released in the substantia nigra for the dendrites of nigrostriatal dopaminergic neurones , to be involved there in the self-regulation of the dopaminergic cells , to control the release of neurotransmitters from nigral afferent fibres and to influence the activity of nigral non-dopaminergic cells . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
0,
8
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
296,
308
]
} |
in the long history of screening for antibiotics , fungi and actinomycetes have been the only producers of beta-lactam antibiotics although several phytopathogenic bacteria have been reported to produce toxins with a beta-lactam structure . | NA | {
"id": "C0026458",
"name": "beta-lactam antibiotics",
"pos": [
107,
130
]
} | {
"id": "C0282215",
"name": "beta-lactam",
"pos": [
217,
228
]
} |
the association between house dust allergy and asthma has long been recognized , and it has been demonstrated that a major allergen in house dust is related to the presence of mites of the genus dermatophagoides . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
123,
131
]
} | {
"id": "C0524581",
"name": "house dust",
"pos": [
135,
145
]
} |
recently , strong evidence for block of ion channels by cationic drug molecules has been obtained by recording current from single ach-activated channels in the presence of permanently charged quaternary derivatives of lignocaine . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
40,
43
]
} | {
"id": "C0007447",
"name": "cationic",
"pos": [
56,
64
]
} |
this phosphorylated protein has similar characteristics to those of the intestinal membrane protein whose synthesis is stimulated by 1,25- ( oh ) 2d . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
20,
27
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
83,
99
]
} |
in bacteria , insertion ( is ) and transposable ( tn ) elements not only translocate their own dna , but also promote the rearrangement of both bacterial chromosomes and the plasmic genomes carrying them . | NA | {
"id": "C0012868",
"name": "transposable",
"pos": [
35,
47
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
95,
98
]
} |
it can also promote the translocation of dna segments flanked by two copies of is1 to give rise to transposable elements responsible for antibiotic resistance and enterotoxin production . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
41,
44
]
} | {
"id": "C0012868",
"name": "transposable",
"pos": [
99,
111
]
} |
in 13 patients the predominant ct finding was an empty sella with variable enhancement of the adenoma and residual pituitary tissue . | NA | {
"id": "C0014008",
"name": "empty sella",
"pos": [
49,
60
]
} | {
"id": "C0032002",
"name": "pituitary",
"pos": [
115,
124
]
} |
in a prospective study of women in the first trimester who were at risk for recurrent abortion , data from 20 pregnancies with normal outcomes were contrasted with those of 9 pregnancies that aborted spontaneously between 7 and 12 weeks . | NA | {
"id": "C0032979",
"name": "first trimester",
"pos": [
39,
54
]
} | {
"id": "C0032961",
"name": "pregnancies",
"pos": [
175,
186
]
} |
moreover , maternal serum estriol and estetrol levels were determined from the same samples in the 4 groups to find a possible relationship with the corresponding copper levels . | NA | {
"id": "C0014927",
"name": "estriol",
"pos": [
26,
33
]
} | {
"id": "C0014899",
"name": "estetrol",
"pos": [
38,
46
]
} |
a simultaneous pattern of acute phase reactants ( alpha 1-glycoprotein , alpha 1-antitrypsin , beta 2-glycoprotein and haptoglobin ) was related to the content of these hormones . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
26,
47
]
} | {
"id": "C0029297",
"name": "alpha 1-glycoprotein",
"pos": [
50,
70
]
} |
a simultaneous pattern of acute phase reactants ( alpha 1-glycoprotein , alpha 1-antitrypsin , beta 2-glycoprotein and haptoglobin ) was related to the content of these hormones . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
26,
47
]
} | {
"id": "C0002191",
"name": "alpha",
"pos": [
73,
78
]
} |
a simultaneous pattern of acute phase reactants ( alpha 1-glycoprotein , alpha 1-antitrypsin , beta 2-glycoprotein and haptoglobin ) was related to the content of these hormones . | NA | {
"id": "C0001347",
"name": "acute phase reactants",
"pos": [
26,
47
]
} | {
"id": "C0018595",
"name": "haptoglobin",
"pos": [
119,
130
]
} |
the shape of the susceptibility distribution is determined by the effects of all environmental carcinogens ( both known and unknown ) to which the population has been exposed , as well as by differences in genetic susceptibility between members of the population . | NA | {
"id": "C0012655",
"name": "susceptibility",
"pos": [
17,
31
]
} | {
"id": "C0314657",
"name": "genetic susceptibility",
"pos": [
206,
228
]
} |
all sessions followed a 10 minute pretreatment with either saline , the training dose of cocaine , four probe doses of cocaine hcl ( 1.0 , 2.5 , 7.5 , 10 mg/kg ) , four probe doses of norcocaine ( 1.0 , 2.5 , 5.0 , 7.5 mg/kg ) or four probe doses of n-allylnorcocaine ( 5.0 , 7.5 , 10 , 20 mg/kg ) . | NA | {
"id": "C0009170",
"name": "cocaine",
"pos": [
89,
96
]
} | {
"id": "C0282108",
"name": "cocaine hcl",
"pos": [
119,
130
]
} |
in this series , 19 cases were treated : 8 recent cases of phlebitis , in which results were all too often imperfect ( 5 failures ) , 11 post-phlebitic syndromes , in which there were 9 good results . | NA | {
"id": "C0031542",
"name": "phlebitis",
"pos": [
59,
68
]
} | {
"id": "C0032807",
"name": "post-phlebitic syndromes",
"pos": [
137,
161
]
} |
twenty-four-hour 201-thallium chloride redistribution images in conjunction with immediate postexercise images were evaluated to determine their value in distinguishing coronary artery ischemia from remote infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
185,
193
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
206,
216
]
} |
[ treatment of diabetes mellitus in the adult or so-called maturity-onset diabetes . the role of oral antidiabetics ] . | NA | {
"id": "C0011849",
"name": "diabetes mellitus",
"pos": [
15,
32
]
} | {
"id": "C0011860",
"name": "maturity-onset",
"pos": [
59,
73
]
} |
3-deazaadenosine may perturb cellular methylation and thereby lead to an increase in the frequency of differentiation of 3t3-l1 fibroblasts to fat cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
29,
37
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
128,
139
]
} |
when prairie dogs ( cynomys ludovicianus ) are fed a diet containing cholesterol , a marked increase in gallbladder mucin secretion parallels the evolution of cholesterol supersaturated bile . | NA | {
"id": "C0008395",
"name": "diet",
"pos": [
53,
57
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
159,
170
]
} |
the severity of the c fetus ssp jejuni gastroenteritis poses a possible reclassification from diarrhea or gastroenteritis to acute dysentery syndrome . | NA | {
"id": "C0017160",
"name": "gastroenteritis",
"pos": [
39,
54
]
} | {
"id": "C0013369",
"name": "dysentery",
"pos": [
131,
140
]
} |
plasma amino acid profiles along with hemoglobin , hematocrit , albumin , protein , blood urea nitrogen and serum creatinine values for ten patients undergoing abdominal operations were studied before operation and for 16 days there-after at different intervals . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
64,
71
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
74,
81
]
} |
we have found sonography clinically helpful in patients with undiagnosed pain in the groin , questionable inguinal or femoral region hernias , masses of the groin , postoperative complaints after inguinal or femoral herniorrhaphies and possible femoral aneurysms or pseudoaneurysms . | NA | {
"id": "C0002940",
"name": "aneurysms",
"pos": [
253,
262
]
} | {
"id": "C1510412",
"name": "pseudoaneurysms",
"pos": [
266,
281
]
} |
previous evidence has documented the hyperglycemia and glucose intolerance that occur during prolonged infusions of somatostatin and in patients with somatostatinoma . | NA | {
"id": "C0020456",
"name": "hyperglycemia",
"pos": [
37,
50
]
} | {
"id": "C0271650",
"name": "glucose intolerance",
"pos": [
55,
74
]
} |
they were classified as adenomas , adenocarcinomas , squamous cell or basal cell carcinomas , and mixed cell carcinomas . | NA | {
"id": "C0007117",
"name": "basal cell carcinomas",
"pos": [
70,
91
]
} | {
"id": "C0007097",
"name": "carcinomas",
"pos": [
109,
119
]
} |
as compared with the rhodamine procedure , use of ans permitted to increase 5-fold the sensitivity of free fatty acid estimation , to elevate 6-fold the accuracy of the analysis , to overcome the step of fatty acid elution from chromatogramms and to decrease the time required for analysis . | NA | {
"id": "C0015688",
"name": "free fatty acid",
"pos": [
102,
117
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
204,
214
]
} |
a spectrum of histologic findings and multiple theories of pathogenesis have resulted in numerous names for the lesion , including multilocular cyst , benign cystic nephroma , cystic hamartoma , cystic lymphangioma , cystic wilms tumor , and perlmann tumor . | NA | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
183,
192
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
251,
256
]
} |
gallstones were diagnosed in 123 cases and surgery or autopsy in 70 of these patients confirmed stones in 69 . | NA | {
"id": "C0008350",
"name": "gallstones",
"pos": [
0,
10
]
} | {
"id": "C0006736",
"name": "stones",
"pos": [
96,
102
]
} |
the purpose of this investigation was to determine whether ventricular ectopic beats , or ventricular premature beats ( vpbs ) , on routine electrocardiograms in men without apparent heart disease predict the later occurrence of clinical manifestations of ischemic heart disease ( ihd ) . | NA | {
"id": "C0018799",
"name": "heart disease",
"pos": [
183,
196
]
} | {
"id": "C0151744",
"name": "the",
"pos": [
205,
208
]
} |
a double-blind , randomized , crossover study was performed in 15 patients with stable angina to evaluate the effect of breathing carbon monoxide ( co ) , which raised the carboxyhemoglobin ( cohb ) from 1.09 % to 2.02 % , versus breathing compressed , purified air , which lowered the cohb from 1.07 % to 1.00 % on exercise duration until angina . | NA | {
"id": "C0340288",
"name": "stable angina",
"pos": [
80,
93
]
} | {
"id": "C0002962",
"name": "angina",
"pos": [
340,
346
]
} |
significant increased in vo2 max , hdl-c , hdl-c/total cholesterol , and a decrease in percent body fat were documented after training . | NA | {
"id": "C0023822",
"name": "hdl-c",
"pos": [
35,
40
]
} | {
"id": "C0008377",
"name": "hdl-c",
"pos": [
43,
48
]
} |
thirty patients with ventricular septal defect and d-transposition of the great arteries or double outlet right ventricle underwent placement of an intraventricular baffle to achieve physiologic correction . | NA | {
"id": "C0040761",
"name": "transposition of the great",
"pos": [
53,
79
]
} | {
"id": "C0013069",
"name": "double outlet right ventricle",
"pos": [
92,
121
]
} |
moreover , the occurrence of coronary aneurysm did not correlate with the presence of signs of carditis , because the frequency of carditis was the same in patients with and without aneurysm . | NA | {
"id": "C0018789",
"name": "of coronary aneurysm",
"pos": [
26,
46
]
} | {
"id": "C0002940",
"name": "aneurysm",
"pos": [
182,
190
]
} |
eighty-eight patients with preexcitation were studied to determine how 30 patients with documented spontaneous paroxysmal atrial fibrillation differed from 58 patients without this arrhythmia . | NA | {
"id": "C0032915",
"name": "preexcitation",
"pos": [
27,
40
]
} | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
181,
191
]
} |
thirteen patients ( all with paroxysmal sustained ventricular tachycardia ) manifested slowing of the tachycardia without conversion , whereas in one patient with incessant ventricular tachycardia , the tachycardia became less frequent and nonsustained after intravenous aprindine . | NA | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
50,
73
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
203,
214
]
} |
recent evidence suggests that immunofluorescence is superior to immunohistochemistry for the study of lymphomas , since the latter procedure often results in identification of polyclonal cytoplasmic immunoglobulins or negative immunostaining in non-hodgkin 's lymphomas marking monoclonal with immunofluorescence . | NA | {
"id": "C0024299",
"name": "lymphomas",
"pos": [
102,
111
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphomas",
"pos": [
245,
269
]
} |
the relationship between serum angiotensin-converting enzyme activity and inflammatory bowel disease was investigated in 37 patients who had crohn 's disease , 31 patients who had ulcerative colitis , and 104 control subjects . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
74,
100
]
} | {
"id": "C0010346",
"name": "crohn 's",
"pos": [
141,
149
]
} |
a newly developed methodology for the assessment of mode of inheritance of continuously distributed traits in nuclear families , structured exploratory data analysis ( seda ) , is applied to lipid and lipoprotein measurements . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
191,
196
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
201,
212
]
} |
furthermore , amino acid analyses of the tryptic peptides indicated that ca1 3n is characterized by the substitution 253 gly leads to arg , confirming the identity of this variant with ca1 guam . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
14,
24
]
} | {
"id": "C0017890",
"name": "gly",
"pos": [
121,
124
]
} |
the invariable association between diuresis and recovery of renal function , the recurrence of renal failure when fluid reaccumulated and the finding of markedly depressed filtration fractions lead us to postulate that renal failure in minimal change nephrotic syndrome may be due to a reversible alteration in glomerular hemodynamics which is related to fluid retention and associated intrarenal edema . | NA | {
"id": "C0037088",
"name": "finding",
"pos": [
142,
149
]
} | {
"id": "C0013604",
"name": "edema",
"pos": [
397,
402
]
} |
the most common diabetes syndromes in animals occur in the context of obesity , hyperinsulinemia and insulin resistance . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
80,
96
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
101,
119
]
} |
the atypical measles syndrome is a relatively new disease that was first recognized 15 years ago . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
21,
29
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
50,
57
]
} |
it was characterized by a two- to three-day prodrome of high fever , cough , headache , and myalgia followed by a rash that resembled rocky mountain spotted fever , scarlet fever , or varicella and associated with roentgenographic evidence of pneumonia with or without pleural effusion . | NA | {
"id": "C0015231",
"name": "three-day",
"pos": [
34,
43
]
} | {
"id": "C0015230",
"name": "rash",
"pos": [
114,
118
]
} |
however , during pregnancy , urinary levels increased to 430 micrograms during the first trimester and 863 micrograms during the third trimester . | NA | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
17,
26
]
} | {
"id": "C0032979",
"name": "first trimester",
"pos": [
83,
98
]
} |
in the cord blood , the percentage of the minor hemoglobin hbf1c , which has been shown to be a mixture of acetylated glycosylated hbf , and the ratios hbf1c/hbf and hba1/hba were significantly increased in fetuses delivered of diabetic mothers . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
48,
58
]
} | {
"id": "C0015936",
"name": "hbf",
"pos": [
158,
161
]
} |
in the cord blood , the percentage of the minor hemoglobin hbf1c , which has been shown to be a mixture of acetylated glycosylated hbf , and the ratios hbf1c/hbf and hba1/hba were significantly increased in fetuses delivered of diabetic mothers . | NA | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
48,
58
]
} | {
"id": "C0019016",
"name": "hba",
"pos": [
171,
174
]
} |
the fetal correlation coefficients were r = -0.56 ( p less than 0.01 ) for plasma glucose compared to norepinephrine and r = -0.58 ( p less than 0.01 ) for plasma glucose compared to epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
102,
116
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
183,
194
]
} |
by means of a modified radioenzymatic assay , simultaneous determinations of the parent catecholamines , epinephrine ( e ) , norepinephrine ( ne ) , and dopamine ( da ) , and their deaminated metabolites , 3,4-dihydroxyphenylacetic acid ( dopac ) and 3,4-dihydroxyphenylglycol ( dopeg ) , were made in amniotic fluid obtained during the second ( n = 44 ) and third ( n = 20 ) trimesters of normal pregnancies . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
105,
116
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
125,
139
]
} |
dipivefrin , an epinephrine prodromal drug , was used in conjunction with timolol maleate to evaluate the safety and effectiveness of combined therapy . | NA | {
"id": "C0058415",
"name": "dipivefrin",
"pos": [
0,
10
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
16,
27
]
} |
results of previous experiments in this laboratory indicate that lipids , especially cholesterol and cholesteryl ester , preferentially accumulate in re-endothelialized , as compared with de-endothelialized , areas of aorta ( am j pathol 1980 , 99:81-104 ) . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
85,
96
]
} | {
"id": "C0008387",
"name": "cholesteryl ester",
"pos": [
101,
118
]
} |
such stimulus could be the result of recent endocytosis of surface receptors in combination with antigen , antibody , or immune complexes and/or recent mitosis , or possibly some unrelated autophagic incident . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
107,
115
]
} | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
121,
137
]
} |
in the absence of 1,25 ( oh ) 2d3 , treatment of cultures for 20-24 h with 10 ( -5 ) and 10 ( -6 ) m estradiol led to inhibition of 25-hydroxyvitamin d3 [ 25 ( oh ) d3 ] -1-hydroxylase activity . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
132,
152
]
} | {
"id": "C2713074",
"name": "25 ( oh ) d3",
"pos": [
155,
167
]
} |
newborn animals had no detectable gastrin binding , high serum gastrin levels ( 800-1,200 pg/ml ) , low antral gastrin levels ( 0.5-2.0 micrograms/g tissue ) , or high ph of gastric contents ( ph greater than 5.0 ) and did not respond to pentagastrin . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
34,
41
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
238,
250
]
} |
monocrotaline , a pyrrolizidine alkaloid derived from crotalaria spectabilis , is known to be toxic to a variety of domestic and laboratory animals and to humans . | NA | {
"id": "C0085241",
"name": "monocrotaline",
"pos": [
0,
13
]
} | {
"id": "C0034335",
"name": "pyrrolizidine alkaloid",
"pos": [
18,
40
]
} |
to establish whether the sensitivity to exogenous bradykinin was affected by the presence of angiotensin , vasodepressor dose-response curves to injected bradykinin were performed in conscious rats before and during a 1-h infusion of angiotensin i ( 30 ng/min ) , angiotensin ii ( 30 and 300 mg/min ) , and [ sar2 , ala8 ] angiotensin ii ( 5 micrograms/min ) . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
93,
104
]
} | {
"id": "C0003006",
"name": "angiotensin i",
"pos": [
323,
336
]
} |
to establish whether the sensitivity to exogenous bradykinin was affected by the presence of angiotensin , vasodepressor dose-response curves to injected bradykinin were performed in conscious rats before and during a 1-h infusion of angiotensin i ( 30 ng/min ) , angiotensin ii ( 30 and 300 mg/min ) , and [ sar2 , ala8 ] angiotensin ii ( 5 micrograms/min ) . | NA | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
93,
104
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
323,
337
]
} |
large amounts of circulating antibody and immune complexes were formed , and their deposition led to peripheral tissue injury . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
29,
37
]
} | {
"id": "C0003313",
"name": "immune",
"pos": [
42,
48
]
} |
we recommend the rahn-otis end-tidal sampler in young infants and children , and the haldane-priestley tube in older children , since these were most acceptable to the children and their parents . | NA | {
"id": "C1455726",
"name": "older children",
"pos": [
111,
125
]
} | {
"id": "C0008059",
"name": "children",
"pos": [
168,
176
]
} |
when the immunofluorescence technique ( ift ) with crithidia luciliae and the farr assay with 3h-labelled-pm2 dna were applied to a selected panel of 536 sera from patients with various well-defined autoimmune diseases , positive results were obtained only with serum samples from patients with systemic lupus erythematosus ( sle ) . | NA | {
"id": "C0004364",
"name": "autoimmune",
"pos": [
199,
209
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
295,
323
]
} |
these results , together with the results on serum antiglobulin levels , indicate that patients with rheumatoid arthritis produce antibodies of both igg and igm immunoglobulin class which may have pathogenetic significance in the more severe arthritis found in this condition . | NA | {
"id": "C0020852",
"name": "antibodies",
"pos": [
130,
140
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
161,
181
]
} |
raised levels of circulating immune complexes were found in the plasma of 47 % of patients with psoriasis and in 58 % of those with psoriatic arthritis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
96,
105
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
132,
151
]
} |
the levels of acute phase proteins ( c-reactive protein , fibrinogen , alpha-1-antitrypsin , and the 9th component of complement ) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
14,
34
]
} | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
37,
55
]
} |
the levels of acute phase proteins ( c-reactive protein , fibrinogen , alpha-1-antitrypsin , and the 9th component of complement ) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
14,
34
]
} | {
"id": "C0016006",
"name": "fibrinogen",
"pos": [
58,
68
]
} |
the levels of acute phase proteins ( c-reactive protein , fibrinogen , alpha-1-antitrypsin , and the 9th component of complement ) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis . | NA | {
"id": "C0001347",
"name": "acute phase proteins",
"pos": [
14,
34
]
} | {
"id": "C0002191",
"name": "alpha-1-antitrypsin",
"pos": [
71,
90
]
} |
the levels of acute phase proteins ( c-reactive protein , fibrinogen , alpha-1-antitrypsin , and the 9th component of complement ) were normal in those patients with psoriasis but were significantly raised in patients with psoriatic arthritis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
166,
175
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
223,
242
]
} |
the most firmly established pain models have used pain caused by cancer , parturition ( including episiotomy ) , surgery postoperatively , oral surgery , and headache . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
28,
32
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
158,
166
]
} |
on the other hand , there is substantial evidence that combinations of an optimal dose of aspirin or acetaminophen with a narcotic ( eg , codeine , hydrocodone , or oxycodone ) produce an additive analgesic effect greater than that obtained by doubling the dose of either constituent administered alone . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
138,
145
]
} | {
"id": "C0020264",
"name": "hydrocodone",
"pos": [
148,
159
]
} |
on the other hand , there is substantial evidence that combinations of an optimal dose of aspirin or acetaminophen with a narcotic ( eg , codeine , hydrocodone , or oxycodone ) produce an additive analgesic effect greater than that obtained by doubling the dose of either constituent administered alone . | NA | {
"id": "C0009214",
"name": "codeine",
"pos": [
138,
145
]
} | {
"id": "C0030049",
"name": "oxycodone",
"pos": [
165,
174
]
} |
we reviewed the previously reported cases of non-hodgkin 's lymphoma with spontaneous myeloid leukemia in the light of our findings , and such cases may , in fact , represent myeloblastomas ( granulocytic sarcomas ) rather than non-hodgkin 's lymphoma . | NA | {
"id": "C0023470",
"name": "myeloid",
"pos": [
86,
93
]
} | {
"id": "C0152276",
"name": "granulocytic sarcomas",
"pos": [
192,
213
]
} |
though no pathognomonic symptoms or syndrome occur in enteric tuberculosis , this disease should be included in the differential diagnosis of patients with vague abdominal complaints , weight loss , and anorexia . | NA | {
"id": "C0039082",
"name": "syndrome",
"pos": [
36,
44
]
} | {
"id": "C0012634",
"name": "disease",
"pos": [
82,
89
]
} |
a comparison of the 21 patients with clinically occult micrometastases shows eight ( 38 % ) alive with ned , whereas four of 20 ( 20 % ) with clinically demonstrable as well as histologically proven nodal metastases are alive with ned . | NA | {
"id": "C1513276",
"name": "micrometastases",
"pos": [
55,
70
]
} | {
"id": "C0027627",
"name": "metastases",
"pos": [
205,
215
]
} |
high-dose vitamin a palmitate reduced the severity of herpetic keratitis , but the low or moderate doses did not , and none of the vitamin a treatments affected virus recovery . | NA | {
"id": "C0073115",
"name": "vitamin a palmitate",
"pos": [
10,
29
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
131,
140
]
} |
guinea pigs were administered chloramphenicol or kanamycin sulfate with ethacrynic acid to compare the ototoxicity of chloramphenicol and ethacrynic acid with the ototoxicity of kanamycin and ethacrynic acid . | NA | {
"id": "C0700540",
"name": "kanamycin sulfate",
"pos": [
49,
66
]
} | {
"id": "C0022487",
"name": "kanamycin",
"pos": [
178,
187
]
} |
side effects necessitated permanent discontinuation of the drug in 2 respondent patients , but in no case did neutropenia or agranulocytosis develop . | NA | {
"id": "C0023530",
"name": "neutropenia",
"pos": [
110,
121
]
} | {
"id": "C0001824",
"name": "agranulocytosis",
"pos": [
125,
140
]
} |
the apo-c peptides of the variant lipoprotein contained 45.2 +/- 1.3 ( n = 9 ) % of apo c-ii compared with 21.5 +/- 5.4 ( n = 30 ) % for hypertriglyceridaemic controls . | NA | {
"id": "C0003594",
"name": "apo-c",
"pos": [
4,
9
]
} | {
"id": "C0052190",
"name": "apo c-ii",
"pos": [
84,
92
]
} |
however , the addition of rabbit lipoprotein-free plasma as a source of exogenous esterified cholesterol transfer activity to incubations of pig lipoproteins resulted in a distribution of the newly formed esterified [ 3h ] cholesterol which was very similar to that in incubated human plasma . | NA | {
"id": "C0008387",
"name": "esterified",
"pos": [
82,
92
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
223,
234
]
} |
when isolated lipoprotein fractions were added to lipoprotein-free plasma in increasing concentration over a physiological range , a highly significant linear relationship between plasma viscosity and chylomicron concentrations ( r = 0.98 , p less than 0.001 ) was apparent . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
14,
25
]
} | {
"id": "C0008731",
"name": "chylomicron",
"pos": [
201,
212
]
} |
a matched case-control study has therefore been performed with cases of malignant lymphoma ( hodgkin 's disease and non-hodgkin lymphoma ) . | NA | {
"id": "C0024299",
"name": "malignant",
"pos": [
72,
81
]
} | {
"id": "C0019829",
"name": "hodgkin 's disease",
"pos": [
93,
111
]
} |
a matched case-control study has therefore been performed with cases of malignant lymphoma ( hodgkin 's disease and non-hodgkin lymphoma ) . | NA | {
"id": "C0024299",
"name": "malignant",
"pos": [
72,
81
]
} | {
"id": "C0024305",
"name": "non-hodgkin lymphoma",
"pos": [
116,
136
]
} |
the secondary phase obeyed first-order kinetics , and the half-life was dependent on the dose of paraquat instilled . | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
39,
47
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
58,
67
]
} |
two primary bile acids , cholic acid ( ca ) and chenodeoxycholic acid ( cdca ) , and one secondary bile acid , deoxycholic acid ( dca ) , were measured by radioimmunoassay in pregnancy serum from 30 healthy women , 49 women with itching and 45 with intrahepatic cholestasis of pregnancy . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
48,
69
]
} | {
"id": "C0011479",
"name": "deoxycholic acid",
"pos": [
111,
127
]
} |
pentagastrin , and analogue of gastrin , depressed intake by 35-50 % ( p less than 0.05 ) when it was infused at 9 microgram/kg per h during 30 min of feeding . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
0,
12
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
31,
38
]
} |
the biological significance of gastrointestinal hormones as signals of satiety in normal sheep is not known since doses of pentagastrin and cck that suppressed intake also interfered quite markedly with motility . | NA | {
"id": "C0017182",
"name": "gastrointestinal hormones",
"pos": [
31,
56
]
} | {
"id": "C0008328",
"name": "cck",
"pos": [
140,
143
]
} |
hepatic and renal flavin contents were directly proportional to dietary riboflavin , fad being conserved at the expense of riboflavin and fmn . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
72,
82
]
} | {
"id": "C0016388",
"name": "fmn",
"pos": [
138,
141
]
} |
an experiment is reported in which copper , as cupric oxide , was fed to two breeds of laying hen for 336 d at levels equivalent to 150 , 300 , 450 , 600 and 750 mg added cu/kg diet . | NA | {
"id": "C0009968",
"name": "copper",
"pos": [
35,
41
]
} | {
"id": "C0056598",
"name": "cupric oxide",
"pos": [
47,
59
]
} |
when incubated with 3t3-l1 fibroblasts , the carbocyclic analogue of adenosine caused a 20-fold increase in the cellular concentration of s-adenosyl-homocysteine . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
27,
38
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
112,
120
]
} |
nicotinamide adenine dinucleotide ( nad ) dependent urocanase ( 4'-imidazolone-5'-propionate hydro-lyase , ec 4.2.1.49 ) from pseudomonas putida was found to catalyze an exchange reaction between solvent and the 4'-hydrogen of urocanate or imidazolepropionate at a rate faster than that of overall deuterium was compared to unlabeled urocanate as a substrate , no isotope rate effect was noted . | NA | {
"id": "C0042053",
"name": "urocanase",
"pos": [
52,
61
]
} | {
"id": "C0020239",
"name": "hydro-lyase",
"pos": [
93,
104
]
} |
nicotinamide adenine dinucleotide ( nad ) dependent urocanase ( 4'-imidazolone-5'-propionate hydro-lyase , ec 4.2.1.49 ) from pseudomonas putida was found to catalyze an exchange reaction between solvent and the 4'-hydrogen of urocanate or imidazolepropionate at a rate faster than that of overall deuterium was compared to unlabeled urocanate as a substrate , no isotope rate effect was noted . | NA | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
215,
223
]
} | {
"id": "C0011744",
"name": "deuterium",
"pos": [
298,
307
]
} |
ca2+ , mg2+-dependent adenosine 5'-triphosphatase ( atpase ) in sarcoplasmic reticulum vesicles is labeled with the triplet probe , 5-iodoacetamidoesin . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
7,
10
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
52,
58
]
} |
the interaction of purified succinate dehydrogenase and succinate -- ubiquinone reductase ( complex ii ) with lipids was explored by using two ( arylazido ) phospholipids , one with the reactive nitrene in the head-group region of the bilayer [ 1-palmitoyl-2- ( 2-azido-4-nitrobenzoyl ) -sn-glycero-3- [ 3h ] phosphocholine ( plii ) ] and one with the nitrene on the methyl terminus of one of the fatty acid chains [ 1-myristoyl-2- [ 12- [ ( 2-azido-4-nitrophenyl ) amino ] lauroyl ] -sn-glycero-3- [ 14c ] phos phocholine ( pli ) ] . | NA | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
28,
51
]
} | {
"id": "C0283592",
"name": "complex ii",
"pos": [
92,
102
]
} |
complex ii was found to interact with lipid vesicles , with the smaller subunit of succinate dehydrogenase , cii-3 , and cii-4 all inserted into the interior of the bilayer . | NA | {
"id": "C0283592",
"name": "complex ii",
"pos": [
0,
10
]
} | {
"id": "C0038615",
"name": "succinate dehydrogenase",
"pos": [
83,
106
]
} |
the large subunit of succinate dehydrogenase was found to be held above the bilayer in complex ii and not labeled by either probe . | NA | {
"id": "C0038615",
"name": "succinate",
"pos": [
21,
30
]
} | {
"id": "C0283592",
"name": "complex ii",
"pos": [
87,
97
]
} |
amino acid composition analyses indicate that the toxin consists of approximately 1018 residues with high content of acidic amino acid residues . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
0,
10
]
} | {
"id": "C0815040",
"name": "acidic amino acid",
"pos": [
117,
134
]
} |
these kinetic differences may provide a means to assay for the protein subunit that converts alpha-c-polymerase to alpha-a1-polymerase , and provide a basis for isolation and characterization of other dna replication-association proteins . | NA | {
"id": "C0599220",
"name": "protein subunit",
"pos": [
63,
78
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
229,
237
]
} |
in contrast , the stokes radius for the factor va present in serum is significantly smaller ( 50.5 a ) and equivalent to the stokes radius obtained upon activation of isolated factor v with thrombin . | NA | {
"id": "C0015501",
"name": "factor va",
"pos": [
40,
49
]
} | {
"id": "C0015498",
"name": "factor v",
"pos": [
176,
184
]
} |
this result is taken as evidence for an imidazolium -- thiolate ion-pair interaction between his-159 and cys-25 wherein neutralization of the charge on the thiolate anion by methylthiolation would be expected to cause a marked decrease in the pk of his-159 . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
64,
67
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
165,
170
]
} |
the amino acid composition is unusual with 11 % by weight of the residues being either proline or hydroxyproline . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
87,
94
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
98,
112
]
} |
insulin mrna sequences were estimated by transcription of insulin mrna to [ 3h ] cdna and hybridization of cdna with plasmid pi19 dna containing rat proinsulin i sequences . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
0,
7
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
149,
159
]
} |
the dynamic behavior of various types of cytochromes c in the redox reaction with iron hexacyanides was studied using a temperature-jump method in order to elucidate the molecular mechanism of the redox reaction of cytochromes with their oxidoreductants . | NA | {
"id": "C1256752",
"name": "types",
"pos": [
32,
37
]
} | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
215,
226
]
} |
under a constant concentration of anion , the redox reaction of various types of cytochrome c with iron hexacyanides was analyzed according to the scheme : ( see formula in text ) where c ( iii ) and c ( ii ) are ferric and ferrous cytochromes , respectively , fe ( iii ) and fe ( ii ) are ferri- and ferrocyanides , respectively , c ( iii ) . fe ( ii ) is the ferricytochrome-ferrocyanide complex and c ( ii ) . fe ( iii ) is the ferrocytochrome-ferricyanide complex . | NA | {
"id": "C1256752",
"name": "types",
"pos": [
72,
77
]
} | {
"id": "C0010798",
"name": "cytochromes",
"pos": [
232,
243
]
} |
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