text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
isolation of the fetal gamma-globin gene and demonstration that the fetal gamma- and adult beta a-globin genes lie within eight kilobase segments of homologous dna . | NA | {
"id": "C0017033",
"name": "gamma-globin",
"pos": [
23,
35
]
} | {
"id": "C0005221",
"name": "beta",
"pos": [
91,
95
]
} |
amino acid analysis of sea raven antifreeze showed that it contains a high amount of half-cystine , hydrophilic amino acids , and only an average amount of alanine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
112,
123
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
156,
163
]
} |
with maximum phospholipid uptake these lipoproteins had a similar density , size , and lipid composition to hdl2a , a phospholipid-rich subfraction of hdl isolated from human plasma between 1.100 to 1.125 g/ml . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
39,
51
]
} | {
"id": "C0023779",
"name": "lipid",
"pos": [
125,
130
]
} |
significant oxidation of gsh occurred during the collection of bile samples resulting in significant time-dependent alterations in the ratio of biliary gsh to gssg . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
25,
28
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
159,
163
]
} |
inhibition of oxidation by acidification of bile during its collection established the true contribution of gsh and gssg to total biliary efflux . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
108,
111
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
116,
120
]
} |
labeling is abolished in a competitive manner by nonradioactive msa but not by similar concentrations of insulin , proinsulin , or epidermal growth factor in all three tissues examined . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
105,
112
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
115,
125
]
} |
if a slight molar excess of cytochrome c is added to the isolated reductase complex in the presence of antimycin , there is rapid reduction of one equivalent of c type cytochrome by succinate , after which reduction of the remaining c type cytochrome is inhibited . | NA | {
"id": "C0010749",
"name": "cytochrome c",
"pos": [
28,
40
]
} | {
"id": "C1256752",
"name": "c type cytochrome",
"pos": [
233,
250
]
} |
oxy hb f , in turn , exhibits a rate indistinguishable from that of oxy hb a . | NA | {
"id": "C0015936",
"name": "hb f",
"pos": [
4,
8
]
} | {
"id": "C0019046",
"name": "hb",
"pos": [
72,
74
]
} |
the fluorescent atp derivative 2',3'-o- ( 2,4,6-trinitrocyclohexadienylidine ) adenosine 5'-triphosphate ( tnp-atp ) binds specifically with enhanced fluorescence to the atp site of purified eel electroplax sodium-potassium adenosine triphosphatase , ( na , k ) -atpase . | NA | {
"id": "C0001479",
"name": "sodium-potassium",
"pos": [
207,
223
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
263,
269
]
} |
extracts of frozen human pituitary glands contain , in addition to normal growth hormone ( hgh ( mr = 22,005 ) , a variant of lower molecular weight ( approximately 20,000 ) ( singh , r. n. p. , seavey , b. k. and lewis , u. j . ( 1974 ) endocrinol . res . commun . 1 , 449-464 ) . | NA | {
"id": "C0037663",
"name": "normal growth",
"pos": [
67,
80
]
} | {
"id": "C3714500",
"name": "hgh",
"pos": [
91,
94
]
} |
formation and characterization of myosin hybrids containing essential light chains and heavy chains from different muscle myosins . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
34,
40
]
} | {
"id": "C0027100",
"name": "heavy chains",
"pos": [
87,
99
]
} |
light chain exchange in nh4cl was also used to hybridize the essential light chains of fast muscle myosin with the heavy chains of cardiac myosin and to hybridize the essential light chains of cardiac myosin with the heavy chains of fast muscle myosin . | NA | {
"id": "C0027096",
"name": "myosin",
"pos": [
99,
105
]
} | {
"id": "C0027100",
"name": "heavy chains",
"pos": [
217,
229
]
} |
while first the amino propeptides and then the carboxyl propeptides were fairly rapidly cleaved from procollagen i , only the carboxyl propeptides were split off procollagen iii , leaving pn-collagen iii . | NA | {
"id": "C0033235",
"name": "procollagen",
"pos": [
101,
112
]
} | {
"id": "C0009325",
"name": "collagen",
"pos": [
191,
199
]
} |
d-ala , mephe , met , enkephalin ( sandoz fk 33-824 ) is a stable long acting analog of methionine-enkephalin . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
22,
32
]
} | {
"id": "C0014295",
"name": "methionine-enkephalin",
"pos": [
88,
109
]
} |
ten patients ingested clomiphene citrate alone , whereas 9 patients continued estrogen treatment during clomiphene supplementation . | NA | {
"id": "C0546859",
"name": "clomiphene citrate",
"pos": [
22,
40
]
} | {
"id": "C0009008",
"name": "clomiphene",
"pos": [
104,
114
]
} |
concentrations of aldosterone , corticosterone , 11-deoxycorticosterone , progesterone , 17-hydroxyprogesterone , 11-deoxycortisol , cortisol , and cortisone determined simultaneously in human amniotic fluid throughout gestation . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
74,
86
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
89,
111
]
} |
previous studies have shown that serum levels of the somatomedin , nonsuppressible insulin-like activity ( nsila-s ) , are extremely low in patients with thalassemia major . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
53,
64
]
} | {
"id": "C0028318",
"name": "nonsuppressible insulin-like activity",
"pos": [
67,
104
]
} |
the adrenocorticoid responses to low dose acth of plasma aldosterone ( aldo ) , corticosterone ( b ) , 11-deoxycorticosterone ( doc ) , 18-hydroxycorticosterone ( 18-ohb ) , 18-hydroxycorticosterone ( 18-oh-doc ) , and cortisol ( f ) were compared . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
80,
94
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
174,
198
]
} |
the addition of guanylylimidodiphosphate or gtp to the incubation mixture increased , in a dose-dependent manner , the apparent kamg of the enzyme in the abnormal tissue toward normal , suggesting a defective nucleotide regulatory site in the adenylate cyclase of hyperparathyroid glands . | NA | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
16,
40
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
44,
47
]
} |
both the 17-hydroxy and 17-deoxy pathways of adrenocortical steroid biosynthesis were examined by measuring serum concentrations of 17-hydroxyprogesterone , cortisol , progesterone , deoxycorticosterone , corticosterone , and aldosterone and the excretion of free deoxycorticosterone , 18-hydroxydeoxycorticosterone , corticosterone , 18-hydroxycorticosterone , cortisol , and aldosterone . | NA | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
132,
154
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
168,
180
]
} |
both the 17-hydroxy and 17-deoxy pathways of adrenocortical steroid biosynthesis were examined by measuring serum concentrations of 17-hydroxyprogesterone , cortisol , progesterone , deoxycorticosterone , corticosterone , and aldosterone and the excretion of free deoxycorticosterone , 18-hydroxydeoxycorticosterone , corticosterone , 18-hydroxycorticosterone , cortisol , and aldosterone . | NA | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
188,
202
]
} | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
335,
359
]
} |
the value of the enzyme-linked immunosorbent assay ( elisa ) for the serological diagnosis of typhoid or paratyphoid fevers was tested with a collection of five sets of sera from 23 individuals who had no history of salmonella infection from a nonendemic area ( set 1 ) and from 143 patients from a highly endemic area ( sets 2 to 5 ) . | NA | {
"id": "C0041466",
"name": "typhoid",
"pos": [
94,
101
]
} | {
"id": "C0036117",
"name": "salmonella infection",
"pos": [
216,
236
]
} |
the value of the enzyme-linked immunosorbent assay ( elisa ) for the serological diagnosis of typhoid or paratyphoid fevers was tested with a collection of five sets of sera from 23 individuals who had no history of salmonella infection from a nonendemic area ( set 1 ) and from 143 patients from a highly endemic area ( sets 2 to 5 ) . | NA | {
"id": "C0030528",
"name": "paratyphoid fevers",
"pos": [
105,
123
]
} | {
"id": "C0036117",
"name": "salmonella infection",
"pos": [
216,
236
]
} |
the relationship between plasmodium falciparum gametocytemia and the complement components c3 , c4 , and c3b was investigated in 141 ambulant rural nigerian school children . | NA | {
"id": "C0009506",
"name": "complement",
"pos": [
69,
79
]
} | {
"id": "C0009511",
"name": "c3b",
"pos": [
105,
108
]
} |
in mongrel dogs , the effect of end-to-side portacaval shunt on plasma , cerebrospinal fluid ( csf ) and brain tyramine , tyrosine , dopamine , norepinephrine , and epinephrine were studied . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
144,
158
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
165,
176
]
} |
female b/w mice spontaneously develop an autoimmune disease that is similar to systemic lupus erythematosus . | NA | {
"id": "C0004364",
"name": "autoimmune disease",
"pos": [
41,
59
]
} | {
"id": "C0024141",
"name": "systemic lupus erythematosus",
"pos": [
79,
107
]
} |
individual variation in the effects of dietary cholesterol on plasma lipoproteins and cellular cholesterol homeostasis in man . | NA | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
39,
58
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
95,
106
]
} |
these effects on plasma lipoproteins were accompanied by three changes in freshly isolated blood mononuclear cells : ( a ) an increase in cell cholesterol content ( mean change , +17 % ; p < 0.01 ) ; | NA | {
"id": "C1321301",
"name": "blood",
"pos": [
91,
96
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
138,
142
]
} |
also , their percent increase in flux of the large protein ( igm ) was greater than for the small protein ( albumin ) ( p < 0.05 ) . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
51,
58
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
108,
115
]
} |
using a panel of monoclonal antibodies and rabbit heteroantisera , we have studied the cell surface markers of peripheral blood ( pb ) sezary cells from six patients with mycosis fungoides or sezary syndrome , disease grouped within the spectrum of cutaneous t cell lymphomas ( ctcl ) . | NA | {
"id": "C0036920",
"name": "sezary syndrome",
"pos": [
192,
207
]
} | {
"id": "C0079773",
"name": "the",
"pos": [
233,
236
]
} |
these results indicate that : ( a ) suppression of hepatic glucose production by physiologic hyperinsulinemia is not impaired by uremia , ( b ) insulin-mediated glucose uptake by the liver is normal in uremic subjects , and ( c ) tissue insensitivity to insulin is the primary cause of insulin resistance in uremia . | NA | {
"id": "C0020459",
"name": "hyperinsulinemia",
"pos": [
93,
109
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
286,
304
]
} |
at least four out of 97 low birth weight ( less than 1750 g ) newborn infants who had received only limited skin disinfection with 3 % hexachlorophane ( hcp ) emulsion developed spongioform myelinopathy in association with detectable amounts of hcp in their brains . | NA | {
"id": "C0977469",
"name": "3",
"pos": [
131,
132
]
} | {
"id": "C0019435",
"name": "hcp",
"pos": [
245,
248
]
} |
ten laboratory strains of oral microorganisms and 17 recent clinical isolates were examined for their ability to concentrate fluoride from a 1 ppm ( 0.05 mm naf ( fluoride solution . | NA | {
"id": "C0037508",
"name": "naf",
"pos": [
157,
160
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
163,
171
]
} |
study of the kinetics of in vitro release of known antigens from short ragweed pollen revealed a slow release of age ( 1.5 % to 4 % release after 16 min ) but a rapid release of other highly allergenic components . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
51,
59
]
} | {
"id": "C0002092",
"name": "allergenic",
"pos": [
191,
201
]
} |
partial delipidization of ldl-in with heptane in the presence of starch permitted selective extraction of greater than 98 % of the neutral lipids from the native lipoprotein particle . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
139,
145
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
162,
173
]
} |
these partially delipidated polar lipid : protein particles were compared with native ldl-in with respect to charge , apoprotein content , suppressive activity for lymphocytes , and specific binding to the lymphocyte ldl-in receptor . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
42,
49
]
} | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
118,
128
]
} |
binding of bacterial endotoxin ( lps ) to encephalitogenic myelin basic protein and modulation of characteristic biologic activities of lps . | NA | {
"id": "C0014264",
"name": "bacterial endotoxin",
"pos": [
11,
30
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
136,
139
]
} |
myelin basic protein , isolated from central nervous system tissue and an inducer of experimental allergic encephalomyelitis in animals , has been demonstrated to form a stable molecular complex with the lipid a region of gram-negative bacterial lipopolysaccharides ( endotoxins ) . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
8,
9
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
246,
265
]
} |
myelin basic protein , isolated from central nervous system tissue and an inducer of experimental allergic encephalomyelitis in animals , has been demonstrated to form a stable molecular complex with the lipid a region of gram-negative bacterial lipopolysaccharides ( endotoxins ) . | NA | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
246,
265
]
} | {
"id": "C0014264",
"name": "endotoxins",
"pos": [
268,
278
]
} |
a number of lipid a-induced characteristic properties of endotoxin , such as b lymphocyte proliferative response in c3h/st mice , complement activation of normal human serum , limulus lysate gelation , and lethal effects in mice , are modified as a result of binding of myelin basic protein with lipopolysaccharides . | NA | {
"id": "C0023767",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
296,
315
]
} |
a number of lipid a-induced characteristic properties of endotoxin , such as b lymphocyte proliferative response in c3h/st mice , complement activation of normal human serum , limulus lysate gelation , and lethal effects in mice , are modified as a result of binding of myelin basic protein with lipopolysaccharides . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
57,
66
]
} | {
"id": "C0023810",
"name": "lipopolysaccharides",
"pos": [
296,
315
]
} |
antiserum against purified human alpha-lymphotoxin ( anti-lt serum ) inhibited an adcc reaction with human pbl as effector cells and antibody-coated mouse p815 mastocytoma cells as targets . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
0,
9
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
133,
141
]
} |
when activated with the mitogenic lectin , concanavalin a , a subset of human peripheral blood mononuclear cells differentiate into potent suppressor cells that negatively modulate both cellular and humoral immune reactions . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
78,
112
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
186,
194
]
} |
the relatively low frequency of ctl-p was enriched nearly 10-fold ( to 1/2300 ) by passage of nude spleen cells over a column of nylon wool . | NA | {
"id": "C0018956",
"name": "ctl-p",
"pos": [
32,
37
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
106,
111
]
} |
after priming nude spleen cells for 7 days in conventional mlc , 1 to 3 % of the mlc cells could be operationally identified as ctl-p . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
26,
31
]
} | {
"id": "C0018956",
"name": "ctl-p",
"pos": [
128,
133
]
} |
the data obtained provide a reproducible reference system of considerable use in ragweed allergen chemistry and enable one to predict conditions for isolation of ragweed antigens . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
89,
97
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
170,
178
]
} |
blood lymphocytes from 18 patients with cutaneous t-cell lymphoma ( sezary syndrome and mycosis fungoides ) were characterized using multiparameter laser flow microfluorimetry ( fmf ) and automated image analysis ( aia ) and the results correlated with routine blood smears , cytogenetic studies and observations made on pha-stimulated normal t-lymphocytes in vitro . | NA | {
"id": "C0079773",
"name": "cutaneous t-cell lymphoma",
"pos": [
40,
65
]
} | {
"id": "C0036920",
"name": "sezary",
"pos": [
68,
74
]
} |
this may be due to a formation of a larger set of antigenic determinants when the hapten was homogenized in freund 's complete adjuvant or to a formation of a larger repertoire of lymphocytes capable of recognizing these determinants as it might be the result of pretreatment with cyclophosphamide . | NA | {
"id": "C0003316",
"name": "antigenic",
"pos": [
50,
59
]
} | {
"id": "C0018593",
"name": "hapten",
"pos": [
82,
88
]
} |
the diffusion of water , methanol and ethanol at constant temperature ( 37 degrees c ) , has been examined over periods up to 4 h . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
25,
33
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
38,
45
]
} |
average permeability coefficients of water , methanol and ethanol were determined as 16.5 +/- 5.9 x 10 ( -3 ) cm hr-1 , 5.6 x 10 ( -3 ) cm hr-1 and 5.8 +/- 3.1 x 10 ( -3 ) cm hr-1 respectively . | NA | {
"id": "C0001963",
"name": "methanol",
"pos": [
45,
53
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
58,
65
]
} |
the butyrophenone neuroleptic spiperone shows the greatest selectivity for these two binding sites , having at least a 3000-fold difference between its dissociation constants ( 2-12 nm versus 35,000 nm ) for the high- and low-affinity sites , respectively . | NA | {
"id": "C0006525",
"name": "butyrophenone",
"pos": [
4,
17
]
} | {
"id": "C0037956",
"name": "spiperone",
"pos": [
30,
39
]
} |
local injections of kainic acid , which destroyed cholinergic and gaba neurons in the caudatoputamen and in the nucleus accumbens , caused a rapid ( 70-90 % ) decrease in the soluble guanylate cyclase and a slower 50-60 % fall in the particulate guanylate cyclase in these nuclei . | NA | {
"id": "C1097411",
"name": "soluble guanylate cyclase",
"pos": [
175,
200
]
} | {
"id": "C0018358",
"name": "guanylate cyclase",
"pos": [
246,
263
]
} |
there was a relative increase in the myelin protein synthesis rate in the starved rats , indicating preferential utilization of limited protein precursors for myelin protein synthesis . | NA | {
"id": "C0033665",
"name": "protein",
"pos": [
44,
51
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
166,
173
]
} |
2,4-dinitrophenol caused some inhibition of [ 4-14c ] ala uptake whereas ouabain , kcn , or amino acids at 1 mm concentration were without effect . | NA | {
"id": "C0002563",
"name": "ala",
"pos": [
54,
57
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
92,
103
]
} |
tyrosine hydroxylase , the rate-limiting enzyme in catecholamine biosynthesis , catalyzes the conversion of tyrosine to dopa , cyclic amp-dependent protein phosphorylation conditions alter tyrosine hydroxylase activity in rat striatal homogenates . | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
51,
64
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
120,
124
]
} |
potassium was superior in releasing the biogenic amines and acetylcholine , while the putative amino acid transmitters were generally releasable by both agents . | NA | {
"id": "C0005496",
"name": "biogenic amines",
"pos": [
40,
55
]
} | {
"id": "C0001041",
"name": "acetylcholine",
"pos": [
60,
73
]
} |
a high performance liquid chromatographic method was modified to analyze simultaneously ceramides , cerebrosides , and higher neutral glycosphingolipids . | NA | {
"id": "C0007745",
"name": "ceramides",
"pos": [
88,
97
]
} | {
"id": "C0007805",
"name": "cerebrosides",
"pos": [
100,
112
]
} |
the contents of glutamic acid , glutamine , taurine , phosphoethanolamine , cystathionine , and homocarnosine remain unchanged for long periods in human brain . | NA | {
"id": "C0061472",
"name": "glutamic",
"pos": [
16,
24
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
32,
41
]
} |
glycine content rises rapidly , as do the contents of most amino acid components of proteins . | NA | {
"id": "C0017890",
"name": "glycine",
"pos": [
0,
7
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
59,
69
]
} |
incubations of isolated sciatic nerves of diabetic rats in a medium containing [ 33p ] orthophosphate gave decreased labeling of phosphatidylinositol and substantial changes in the labeling pattern of phosphatidylinositol phosphate and 4,5-bisphosphate from that of controls . | NA | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
129,
149
]
} | {
"id": "C0071655",
"name": "phosphatidylinositol phosphate",
"pos": [
201,
231
]
} |
and that it does not change the apparent km 's for substrates , l-tryptophan and oxygen , and coenzyme , reduced biopterin or dmph4 ; | NA | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
94,
102
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
113,
122
]
} |
maximal stimulation by 100 microm-dopamine resulted in a 5 -- 10-fold increase in adenylate cyclase activity with half-maximal stimulation occurring at a concentration of 1 microm . l-noradrenaline and l-adrenaline were some 10 times less potent than dopamine whilst the alpha- and beta-adrenoreceptor agonists , l-phenylephrine and dl-isoprenaline were inactive . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
184,
197
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
204,
214
]
} |
labeling of the ppi precursors , phosphatidic acid ( pa ) and phosphatidylinositol ( pi ) , was considerably lower in the purified myelin than in total brain . | NA | {
"id": "C0071655",
"name": "ppi",
"pos": [
16,
19
]
} | {
"id": "C0031621",
"name": "phosphatidylinositol",
"pos": [
62,
82
]
} |
rapid uptake of adenosine is apparently mediated by a nucleoside carrier , a conclusion based on its inhibition by a variety of purine and pyrimidine nucleosides . | NA | {
"id": "C0028621",
"name": "nucleoside",
"pos": [
54,
64
]
} | {
"id": "C0034287",
"name": "pyrimidine nucleosides",
"pos": [
139,
161
]
} |
male albino rats were exposed to manganese through drinking solution containing mncl2 . 4h2o ( 1 mg/ml ) in water . | NA | {
"id": "C0024706",
"name": "manganese",
"pos": [
33,
42
]
} | {
"id": "C0065642",
"name": "mncl2",
"pos": [
80,
85
]
} |
the loss of this excitability correlates with the simultaneous dissolution of the subaxolemmal network of cytoskeletal proteins and the release of its proteins into the perfusate . | NA | {
"id": "C0010852",
"name": "cytoskeletal proteins",
"pos": [
106,
127
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
151,
159
]
} |
the authors report the late results of surgical treatment of 129 intramedullary gliomas ( 48 ependymomas , 53 astrocytomas , 13 spongioblastomas , five glioblastomas , one oligodendroglioma , and nine others ) , with follow-up periods ranging from 1 to 27 years . | NA | {
"id": "C0017638",
"name": "gliomas",
"pos": [
80,
87
]
} | {
"id": "C0014474",
"name": "ependymomas",
"pos": [
93,
104
]
} |
the authors report the late results of surgical treatment of 129 intramedullary gliomas ( 48 ependymomas , 53 astrocytomas , 13 spongioblastomas , five glioblastomas , one oligodendroglioma , and nine others ) , with follow-up periods ranging from 1 to 27 years . | NA | {
"id": "C0004114",
"name": "astrocytomas",
"pos": [
110,
122
]
} | {
"id": "C0017636",
"name": "glioblastomas",
"pos": [
152,
165
]
} |
the presence of a subdural hematoma could only be suggested by thickened arachnoid structures crossing the hypodense area , indicating the wall between cyst and hematoma . | NA | {
"id": "C0018946",
"name": "subdural hematoma",
"pos": [
18,
35
]
} | {
"id": "C0018944",
"name": "hematoma",
"pos": [
161,
169
]
} |
[ 19f ] fluoro-3-deoxy-glucose [ 3-fdg ( f-18 ) ] was studied to determine whether it is a suitable tracer for evaluating the metabolic function of the brain and myocardium . | NA | {
"id": "C0011501",
"name": "deoxy-glucose",
"pos": [
17,
30
]
} | {
"id": "C0046056",
"name": "fdg",
"pos": [
35,
38
]
} |
102 : 1009 , 1972 ) that cholesterol intake early in life is inversely related to an animal 's subsequent hypercholesterolemic response to dietary cholesterol was tested . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
25,
36
]
} | {
"id": "C0008395",
"name": "dietary cholesterol",
"pos": [
139,
158
]
} |
recent evidence that pyridoxal phosphate may interact with glucocorticoid receptors raises the possibility that the role of vitamin b-6 in these and other organs may involve metabolic regulation by a mechanism independent of the well-established coenzyme function of this vitamin . | NA | {
"id": "C0034266",
"name": "pyridoxal phosphate",
"pos": [
21,
40
]
} | {
"id": "C0009235",
"name": "coenzyme",
"pos": [
246,
254
]
} |
the metabolism and elimination of chloramphenicol-3-monosuccinate was studied in 45 infants and children , ages 3 days to 16 years , during intravenous administration . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
4,
14
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
19,
30
]
} |
acyclovir [ 9- ( 2-hydroxyethoxymethyl ) guanine , zoviraxtm ] is a selective antiviral agent with indications for the treatment of the herpes virus group of injections . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
0,
9
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
41,
48
]
} |
the results are discussed in terms of the role of strionigral pathways in mediating the acute effects of kainic acid on the nigrostriatal dopaminergic system and are interpreted in light of the recently described phenomenon of presumed dopamine cell depolarization inactivation . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
138,
150
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
236,
244
]
} |
the phenethylamine compounds da , epinine , ( - ) -norepinephrine , ( + ) -norepinephrine , ( - ) -epinephrine , ( + ) -epinephrine and ( - ) -phenylephrine are active at similar concentrations . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
51,
65
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
120,
131
]
} |
sickle cell lung disease , or acute `` '' chest syndrome , '' '' occurs with greatest frequency in adults , is due primarily to pulmonary infarction , and may lead to cor pulmonale . | NA | {
"id": "C0002895",
"name": "sickle cell",
"pos": [
0,
11
]
} | {
"id": "C0742343",
"name": "acute",
"pos": [
30,
35
]
} |
four of them died of severe blunt injury , three of moderate injuries combined with traumatic asphyxia and suffocation . | NA | {
"id": "C0011065",
"name": "died",
"pos": [
13,
17
]
} | {
"id": "C0004044",
"name": "suffocation",
"pos": [
107,
118
]
} |
a gradation of myocardial injury , including transient arrhythmia , contusion , and lethal ventricular fibrillation , can be produced by varying the power of the charge in a modified captive bolt pistol . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
55,
65
]
} | {
"id": "C0042510",
"name": "ventricular fibrillation",
"pos": [
91,
115
]
} |
isolated rat livers were perfused for 90 minutes at temperatures from 37 degrees to 43 degrees c. to evaluate the effects of heat alone on bile production , alanine aminotransferase , and asparate aminotransferase release , and light and electron microscopic structure . | NA | {
"id": "C0001899",
"name": "alanine aminotransferase",
"pos": [
157,
181
]
} | {
"id": "C0002594",
"name": "aminotransferase",
"pos": [
197,
213
]
} |
calculations based on the arteriovenous differences of adrenaline and noradrenaline suggest that adrenal medullary secretion contributed less than 2 % of circulating noradrenaline in the non-tumour patients . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
55,
65
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
166,
179
]
} |
plasma-adrenaline , however , is derived almost entirely from the adrenal gland , and its estimation appears superior to that of noradrenaline in the detection of a small adrenal phaeochromocytoma . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
129,
142
]
} |
the effect of induced protein deficiency on sister chromatid exchange ( sce ) frequency in experimental protein energy malnutrition ( pem ) was investigated . | NA | {
"id": "C0033626",
"name": "of",
"pos": [
11,
13
]
} | {
"id": "C0033677",
"name": "protein energy malnutrition",
"pos": [
104,
131
]
} |
effects of dietary fat versus carbohydrate on lipoprotein and hepatic lipids and tissue triglyceride lipases . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
46,
57
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
70,
76
]
} |
a significant contribution of lipoprotein remnants to the triglyceride rise in d < 1.006 lipoproteins seems unlikely since an isolated increase in vldl cholesterol is not observed . | NA | {
"id": "C0065058",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
89,
101
]
} |
none of four amino acids tested orally ( arginine , leucine , alanine , and phenylalanine ) caused increases in ir-gip concentrations , but they increased insulin concentrations . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
13,
24
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
82,
89
]
} |
although glucose-induced ir-gip responses were not inhibited by the amino acids ( 1 g/kg ) tested , increasing concentrations ( up to 1 g/kg ) of either alanine or arginine caused progressive inhibition of corn-oil-stimulated ir-gip responses , in spite of the expected amino-acid-induced rises in insulin concentrations . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
153,
160
]
} | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
270,
280
]
} |
in four patients , tsh suppressive doses of d-t4 were associated with a 12 % decrease in mean cholesterol and a 17 % decrease in mean ldl cholesterol concentrations . | NA | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
94,
105
]
} | {
"id": "C0023824",
"name": "in",
"pos": [
126,
128
]
} |
the largest reported kindred of a proband with type iii hyperlipoproteinemia was investigated by assessment of lipid and lipoprotein levels and very low density lipoprotein ( vldl ) isoapolipoprotein e distributions in all accessible family members ( 56 % of the 124 living blood relatives and 59 % of the 37 spouses ) . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
111,
116
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
188,
199
]
} |
the largest reported kindred of a proband with type iii hyperlipoproteinemia was investigated by assessment of lipid and lipoprotein levels and very low density lipoprotein ( vldl ) isoapolipoprotein e distributions in all accessible family members ( 56 % of the 124 living blood relatives and 59 % of the 37 spouses ) . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
61,
72
]
} | {
"id": "C0023825",
"name": "very low density",
"pos": [
144,
160
]
} |
since the isolation of the enkephalins five yr ago , there has been an explosive increase in knowledge concerning the effects of the opiates and opioid peptides . | NA | {
"id": "C0014298",
"name": "enkephalins",
"pos": [
27,
38
]
} | {
"id": "C0205753",
"name": "opioid peptides",
"pos": [
145,
160
]
} |
patients with unstable angina pectoris who reported chest pain within 24 hours of study had higher txb2 cs/ao ratios ( 5.8 +/- 2.8 , mean +/- s.d . ) than patients whose most recent anginal pain was more than 96 hours before study ( 1.3 +/- 0.6 ; p less than 0.05 ) , than those with nonischemic chest pain ( 1.2 +/- 0.4 ; p less than 0.05 ) , or with valvular or congenital nonischemic heart disease ( 1.2 +/- 0.6 ; p less than 0.05 ) . | NA | {
"id": "C0002965",
"name": "unstable",
"pos": [
14,
22
]
} | {
"id": "C0002962",
"name": "anginal pain",
"pos": [
182,
194
]
} |
these data suggest that local thromboxane release is associated with recent episodes of angina in patients with unstable angina pectoris , but whether this release is a cause or an effect is not yet known . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
88,
94
]
} | {
"id": "C0002965",
"name": "unstable",
"pos": [
112,
120
]
} |
in addition to reducing the clearance of intravenous propranolol by decreasing live blood flow , cimetidine also inhibited the metabolism of oral propranolol and thereby further reduced elimination . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
127,
137
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
186,
197
]
} |
although the 12e7 and xga antigens seem to be different antigenic determinants specified by different loci , we report here a sex-limited effect involving the xg phenotype on the expression of 12e7 antigen . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
56,
78
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
198,
205
]
} |
we report here the simultaneous localization , in the same histological section , of 3h-oestradiol and the enzyme dopamine-beta-hydroxylase in neurones of the rat lower brain stem with a combined technique of thaw-mount autoradiography and immunohistochemistry , demonstrating that noradrenaline- or adrenaline-containing neurones are oestradiol target cells . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
282,
295
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
300,
310
]
} |
we have compared the distribution of oxytocin , vasopressin and enkephalin immunoreactivity ( ir ) in the neurohypophysis of the rat , and report here that met-enkephalin-ir is invariably associated with nerve terminals that contain oxytocin-ir whereas the terminals that contain vasopressin-ir often , but not invariably , are leu-enkephalin immunoreactive . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
64,
74
]
} | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
156,
170
]
} |
we have compared the distribution of oxytocin , vasopressin and enkephalin immunoreactivity ( ir ) in the neurohypophysis of the rat , and report here that met-enkephalin-ir is invariably associated with nerve terminals that contain oxytocin-ir whereas the terminals that contain vasopressin-ir often , but not invariably , are leu-enkephalin immunoreactive . | NA | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
64,
74
]
} | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
328,
342
]
} |
the c-terminal portion of glicentin consists of the sequence of glucagon extended at its c terminus by an octapeptide , and differs slightly from the sequence of a proposed fragment of proglucagon . | NA | {
"id": "C0061309",
"name": "glicentin",
"pos": [
26,
35
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
185,
196
]
} |
the c-terminal portion of glicentin consists of the sequence of glucagon extended at its c terminus by an octapeptide , and differs slightly from the sequence of a proposed fragment of proglucagon . | NA | {
"id": "C0017687",
"name": "glucagon",
"pos": [
64,
72
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
185,
196
]
} |
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