text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in order to grade motion sickness objectively , the following 11 adrenal hormones were investigated in subjects with different motion sickness susceptibility : aldosterone , corticosterone , 11-deoxycorticosterone , progesterone , 17-oh-progesterone , 11-deoxycortisol , cortisol , cortisone , testosterone , androstendi... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
216,
228
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
231,
249
]
} |
thus , chromosomal rearrangements induced by dtmp deprivation may be the critical changes that lead to oncogenic transformation in response to thymine nucleotide depletion . | NA | {
"id": "C0040079",
"name": "dtmp",
"pos": [
45,
49
]
} | {
"id": "C0040090",
"name": "thymine nucleotide",
"pos": [
143,
161
]
} |
the human enzyme required a reducing system , ascorbic acid and methylene blue , for maximal activity and was able to oxidize d-tryptophan , 5-hydroxy-l-tryptophan as well as l-tryptophan , but kinetic studies indicated that the best substrate of the enzyme was l-tryptophan . | NA | {
"id": "C0000578",
"name": "5-hydroxy-l-tryptophan",
"pos": [
141,
163
]
} | {
"id": "C0041249",
"name": "l-tryptophan",
"pos": [
262,
274
]
} |
heparan sulphate and heparin are chemically related alpha beta-linked glycosaminoglycans composed of alternating sequences of glucosamine and uronic acid . | NA | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
0,
16
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
70,
88
]
} |
heparan sulphate and heparin are chemically related alpha beta-linked glycosaminoglycans composed of alternating sequences of glucosamine and uronic acid . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
21,
28
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
70,
88
]
} |
we conclude from these and other observations that heparan sulphate and heparin are separate families of n-sulphated glycosaminoglycans . | NA | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
51,
67
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
117,
135
]
} |
we conclude from these and other observations that heparan sulphate and heparin are separate families of n-sulphated glycosaminoglycans . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
72,
79
]
} | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
117,
135
]
} |
caldesmon was not a substrate of myosin light-chain kinase or phosphorylase kinase , both calmodulin-activated protein kinases . | NA | {
"id": "C0031713",
"name": "phosphorylase kinase",
"pos": [
62,
82
]
} | {
"id": "C0033640",
"name": "protein kinases",
"pos": [
111,
126
]
} |
results are presented that permitted characterization of ten of these antibodies with respect to their immunoglobulin class , their recognition of calf or human terminal-transferase mr species by immunoblotting techniques and their recognition of distinct antigenic sites . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
70,
80
]
} | {
"id": "C0021017",
"name": "immunoglobulin class",
"pos": [
103,
123
]
} |
these findings suggest that wga binds with high affinity to internal glcnac residues in large oligosaccharides containing repeat sequences of gal beta ( 1 -- -- 4 ) glcnac beta ( 1 -- -- 3 ) ( i.e . polylactosamine-type glycans ) . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
94,
110
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
220,
227
]
} |
similarity in the amino acid composition was observed , but immunological cross-reactivity was not observed among alanine : glyoxylate aminotransferases from yeast and vertebrate liver . | NA | {
"id": "C0002520",
"name": "amino",
"pos": [
18,
23
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
114,
121
]
} |
both enzymes were capable of degrading endogenously labelled neuronal proteins , including slowly axonally transported soluble proteins and rapidly transported membrane-bound proteins , as well as casein . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
70,
78
]
} | {
"id": "C0007292",
"name": "transported",
"pos": [
148,
159
]
} |
derivatives of glyoxal bis ( guanylhydrazone ) ( gbg ) , such as methylglyoxal bis ( guanylhydrazone ) and ethylglyoxal bis ( guanylhydrazone ) , are potent inhibitors of s-adenosylmethionine decarboxylase ( ec 4.1.1.50 ) , the key enzyme required for the synthesis of spermidine and spermine . | NA | {
"id": "C0017992",
"name": "glyoxal",
"pos": [
15,
22
]
} | {
"id": "C0034338",
"name": "methylglyoxal",
"pos": [
65,
78
]
} |
'cafeteria diet ' induced an increase of the 32 kda uncoupling protein in electrophoresed proteins of brown-fat mitochondria . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} | {
"id": "C0949610",
"name": "proteins",
"pos": [
90,
98
]
} |
the bacterium grew with cyanuric acid , biuret , urea or nh4+ as sole source of nitrogen , and each substrate was entirely metabolized concomitantly with growth . | NA | {
"id": "C0005667",
"name": "biuret",
"pos": [
40,
46
]
} | {
"id": "C0041942",
"name": "urea",
"pos": [
49,
53
]
} |
biuret ( 1 mol ) was converted stoichiometrically into 1.1 mol of nh4+ , about 1 mol of co2 and 1.0 mol of urea , which was conclusively identified . | NA | {
"id": "C0005667",
"name": "biuret",
"pos": [
0,
6
]
} | {
"id": "C0041942",
"name": "urea",
"pos": [
107,
111
]
} |
the procedure involves extraction with non-ionic detergent and h.p.l.c . using , sequentially , gel-permeation , anion-exchange and reverse-phase columns . | NA | {
"id": "C0022023",
"name": "ionic",
"pos": [
43,
48
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
113,
118
]
} |
in particular , the technique was used to study the kinetics of pa mrna formation in a human melanoma cell line ( bowes ) after exposure to the tumour promoter 12-o-tetradecanoylphorbol 13-acetate ( tpa ) . | NA | {
"id": "C0032144",
"name": "pa",
"pos": [
3,
5
]
} | {
"id": "C0032143",
"name": "tpa",
"pos": [
199,
202
]
} |
the effect was time- and dose-dependent : the increase in pa-specific mrna was clearly visible as early as 4 h after initiation of tpa treatment in bowes cells . | NA | {
"id": "C0032144",
"name": "pa",
"pos": [
58,
60
]
} | {
"id": "C0032143",
"name": "tpa",
"pos": [
131,
134
]
} |
it was blocked completely by pretreatment of the cells with actinomycin d , indicating that tpa caused enhancement of synthesis of pa mrna rather than inhibition of pa mrna degradation . | NA | {
"id": "C0032143",
"name": "tpa",
"pos": [
92,
95
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
165,
167
]
} |
it is concluded that endopeptidase-24.11 has the general capacity to hydrolyse and inactivate the family of tachykinin peptides , including substance p and neurokinin a . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
108,
118
]
} | {
"id": "C0038585",
"name": "substance p",
"pos": [
140,
151
]
} |
it is concluded that endopeptidase-24.11 has the general capacity to hydrolyse and inactivate the family of tachykinin peptides , including substance p and neurokinin a . | NA | {
"id": "C0039241",
"name": "tachykinin",
"pos": [
108,
118
]
} | {
"id": "C0038581",
"name": "neurokinin a",
"pos": [
156,
168
]
} |
the procedure is based on acetolysis of the intact glycoconjugate , extraction of the peracetylated carbohydrate fragments and analysis by fast atom bombardment mass spectrometry . | NA | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
51,
65
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
100,
112
]
} |
high mannose oligosaccharides yield a series of peracetylated hexose oligomers whereas complex-type oligosaccharides afford a series of n-acetyl-lactosamine containing species . | NA | {
"id": "C0024742",
"name": "mannose",
"pos": [
5,
12
]
} | {
"id": "C0019494",
"name": "hexose",
"pos": [
62,
68
]
} |
lectin stimulation of human peripheral blood mononuclear cells causes an increase in neopterin , biopterin , 6-hydroxymethylpterin and 6-formylpterin , as was determined by hplc after iodine oxidation of the acid extract . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
85,
94
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
97,
106
]
} |
the release of both cellular neopterin and biopterin , but not of 6-hydroxymethylpterin and its aldehyde , is controlled by interferon-gamma . | NA | {
"id": "C0068527",
"name": "neopterin",
"pos": [
29,
38
]
} | {
"id": "C0005562",
"name": "biopterin",
"pos": [
43,
52
]
} |
cis-unsaturated fatty acids such as arachidonate or oleate stimulated synexin polymerization at sub-micromolar concentrations , while saturated fatty acids , a trans unsaturated fatty acid or a fatty acid methyl ester had little effect . | NA | {
"id": "C0015690",
"name": "unsaturated",
"pos": [
4,
15
]
} | {
"id": "C1257879",
"name": "trans",
"pos": [
160,
165
]
} |
[ 3h ] inositol phosphates ( ip2 and ip3 ) were generated upon incubation of membranes from [ 3h ] inositol-labeled cells indicating the presence of a membrane-associated polyphosphoinositide phosphodiesterase ( ppi pde ) . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
7,
15
]
} | {
"id": "C0021549",
"name": "ip3",
"pos": [
37,
40
]
} |
[ 3h ] inositol phosphates ( ip2 and ip3 ) were generated upon incubation of membranes from [ 3h ] inositol-labeled cells indicating the presence of a membrane-associated polyphosphoinositide phosphodiesterase ( ppi pde ) . | NA | {
"id": "C0021554",
"name": "inositol",
"pos": [
7,
15
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
99,
107
]
} |
the effects of superoxide dismutase , catalase , and hydroxyl radical scavengers on the reaction provide evidence for superoxide formation as the rate determing step followed by fast reactions that involve peroxide and hydroxyl radical . | NA | {
"id": "C0038836",
"name": "superoxide",
"pos": [
15,
25
]
} | {
"id": "C0031180",
"name": "peroxide",
"pos": [
206,
214
]
} |
although the total amount of cerebroside was not different , the relative proportion of the bands of glucosylceramide separated on borated thin-layer plates was greatly modified in the disease . | NA | {
"id": "C0007805",
"name": "cerebroside",
"pos": [
29,
40
]
} | {
"id": "C0017770",
"name": "glucosylceramide",
"pos": [
101,
117
]
} |
male long-evans rats consumed the alcohol and aldehyde dehydrogenase inhibitors pyrazole , cyanamide or disulfiram , for 6 days . | NA | {
"id": "C2917344",
"name": "aldehyde dehydrogenase inhibitors",
"pos": [
46,
79
]
} | {
"id": "C0012772",
"name": "disulfiram",
"pos": [
104,
114
]
} |
with [ me-14c ] choline , labelling of cell pellet , intracellular choline , phosphocholine and total lipid extract is inhibited by hemicholinium-3 in a dose-dependent way between 6.25 x 10 ( -6 ) m and 10 ( -3 ) m . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
16,
23
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
77,
91
]
} |
it is concluded that hemicholinium-3 might be able to induce a depression of the intracellular choline and phosphocholine pool which could provoke a serious quantitative deficiency of major phospholipids in krebs cells . | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
95,
102
]
} | {
"id": "C0031716",
"name": "phosphocholine",
"pos": [
107,
121
]
} |
polymyxin b ( pb ) , a cationic polypeptide antibiotic , binds lipid a , the active moiety of lps , with high affinity and abrogates several biological responses to lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
63,
70
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
165,
168
]
} |
hapten inhibition studies revealed that the antigenic determinant contained cp and a lysine residue from the protein carrier . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
0,
6
]
} | {
"id": "C0003316",
"name": "antigenic determinant",
"pos": [
44,
65
]
} |
the specificity of the serum igg anti-cp activity after immunization with disulphide-linked cp-s-s-protein conjugates was confirmed since anti-cp activity was inhibited by preincubation of the antisera with cp conjugated to an unrelated protein carrier ( cp-s-s-ova ) , but not by the corresponding unconjugated protein ... | NA | {
"id": "C0007292",
"name": "protein carrier",
"pos": [
237,
252
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
347,
354
]
} |
the effect of adrenal steroids ( mineralo- and glucocorticoids ) as well as that of the adrenocorticotrophic peptide tetracosactide ( beta 1-24 corticotropin ) on the renal kallikrein activity and on the urinary kallikrein excretion of rats was investigated . | NA | {
"id": "C0010192",
"name": "tetracosactide",
"pos": [
117,
131
]
} | {
"id": "C0001655",
"name": "corticotropin",
"pos": [
144,
157
]
} |
the time dependent increase in labelled phospholipids is indicative of a recycling of the choline methyl-groups in this lipid fraction via cdpcholine and/or s-adenosylmethionine ; | NA | {
"id": "C0008405",
"name": "choline",
"pos": [
90,
97
]
} | {
"id": "C0010725",
"name": "cdpcholine",
"pos": [
139,
149
]
} |
[ use of an rnase inhibitor from the human placenta in specific fragmentation of high molecular weight rna by ribonuclease h ] . | NA | {
"id": "C0014241",
"name": "rnase",
"pos": [
12,
17
]
} | {
"id": "C0085431",
"name": "ribonuclease h",
"pos": [
110,
124
]
} |
the lipopolysaccharide from pseudomonas aeruginosa o12 ( lanyi classification ) gave on mild acid hydrolysis an o-specific polysaccharide built of d-ribose and n-acetyl-d-galactosamine . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
4,
22
]
} | {
"id": "C0069180",
"name": "o-specific polysaccharide",
"pos": [
112,
137
]
} |
both forms contain the related antigenic determinants but have some differences in the antigenic structure . | NA | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
31,
53
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
87,
96
]
} |
the potency of the method is demonstrated by cloning a single-stranded polynucleotide a ( 93 nucleotide residues ( n. r. ] in plasmid vector pbr327 . | NA | {
"id": "C0032550",
"name": "polynucleotide",
"pos": [
71,
85
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
93,
103
]
} |
lack of correlation between blood gold concentrations and clinical response in patients with definite or classic rheumatoid arthritis receiving auranofin or gold sodium thiomalate . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
144,
153
]
} |
lack of correlation between blood gold concentrations and clinical response in patients with definite or classic rheumatoid arthritis receiving auranofin or gold sodium thiomalate . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
34,
38
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
157,
179
]
} |
we investigated the correlation between whole blood gold concentrations and clinical outcomes in 59 auranofin-treated patients and 51 gold sodium thiomalate-treated patients who completed a 21-week , placebo-controlled , multicenter parallel trial . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
52,
56
]
} | {
"id": "C0004320",
"name": "auranofin",
"pos": [
100,
109
]
} |
we investigated the correlation between whole blood gold concentrations and clinical outcomes in 59 auranofin-treated patients and 51 gold sodium thiomalate-treated patients who completed a 21-week , placebo-controlled , multicenter parallel trial . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
52,
56
]
} | {
"id": "C0018034",
"name": "gold sodium",
"pos": [
134,
145
]
} |
fifty-three patients ( 34 who had diffuse scleroderma , and 19 who had crest syndrome [ calcinosis , raynaud 's phenomenon , esophageal dysmotility , sclerodactyly , and telangiectasias ] ) were studied by noninvasive procedures , including resting electrocardiogram ( ecg ) , continuous 24-hour holter ecg monitoring , ... | NA | {
"id": "C0206138",
"name": "crest",
"pos": [
71,
76
]
} | {
"id": "C0006663",
"name": "calcinosis",
"pos": [
88,
98
]
} |
forty-eight patients had ventricular arrhythmias , with multiform ventricular premature beats in 21 ( 40 % ) , pairs of runs of ventricular tachycardia in 15 patients ( 28 % ) , and 1 or more runs of ventricular tachycardia in 7 ( 13 % ) . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
140,
151
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
200,
223
]
} |
hospital records from 1974 through 1983 contained the cases of 20 patients over 18 years old admitted with supraglottitis ( epiglottitis ) . | NA | {
"id": "C0749165",
"name": "supraglottitis",
"pos": [
107,
121
]
} | {
"id": "C0014541",
"name": "epiglottitis",
"pos": [
124,
136
]
} |
the pre-operative diagnosis of choledocholithiasis , or common bile-duct stones , is important in patients with cholelithiasis . | NA | {
"id": "C0701818",
"name": "choledocholithiasis",
"pos": [
31,
50
]
} | {
"id": "C0008350",
"name": "cholelithiasis",
"pos": [
112,
126
]
} |
blood ethanol concentrations ( bec ) were determined in long-sleep ( ls ) and short-sleep ( ss ) mice during a 30 min period following ethanol ( etoh ) administration . | NA | {
"id": "C0684262",
"name": "blood ethanol concentrations",
"pos": [
0,
28
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
135,
142
]
} |
differences in absorption rate and peak bec are concluded to be unrelated to etoh neurosensitivity in these mice . | NA | {
"id": "C0684262",
"name": "bec",
"pos": [
40,
43
]
} | {
"id": "C0001962",
"name": "etoh",
"pos": [
77,
81
]
} |
immune complexes ( ic ) formed in the presence of excess antigen with native human anionic ( aa ) or cationic ( ca ) albumin and anti-human albumin rabbit gamma globulin were administered to 51 female wistar rats . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
117,
124
]
} | {
"id": "C0304925",
"name": "human albumin",
"pos": [
134,
147
]
} |
this plasminogen activator was removed by passage through a sepharose column coupled with a monoclonal antibody against t-pa , but not by passage through a column coupled with a monoclonal antibody against u-pa . | NA | {
"id": "C0032144",
"name": "plasminogen activator",
"pos": [
5,
26
]
} | {
"id": "C0032143",
"name": "t-pa",
"pos": [
120,
124
]
} |
our clinical and immunological studies of 114 cases of systemic sclerosis , 54 of raynaud 's disease and 46 of other connective tissue diseases , centered on the diagnostic and prognostic significance of anticentromere antibodies ( aca ) . | NA | {
"id": "C0036421",
"name": "systemic sclerosis",
"pos": [
55,
73
]
} | {
"id": "C0009782",
"name": "of",
"pos": [
201,
203
]
} |
the aca occurred in 21 of 84 patients with acrosclerosis , in four of 54 patients with raynaud 's disease but in none of 30 patients with diffuse scleroderma or transitional form , acrosclerosis-diffuse scleroderma , or 46 cases of other connective tissue diseases . | NA | {
"id": "C0036421",
"name": "diffuse scleroderma",
"pos": [
138,
157
]
} | {
"id": "C0009782",
"name": "of",
"pos": [
229,
231
]
} |
these results also indicate that in humans contact sensitivity to candida antigen occurs during later life because c. albicans is a ubiquitous organism . | NA | {
"id": "C0982054",
"name": "candida antigen",
"pos": [
66,
81
]
} | {
"id": "C0006837",
"name": "c",
"pos": [
122,
123
]
} |
previous studies have indicated that retinoids , such as all-trans-retinoic acid and 13-cis-retinoic acid , can modulate connective tissue metabolism in human skin fibroblast cultures . | NA | {
"id": "C0035339",
"name": "retinoids",
"pos": [
37,
46
]
} | {
"id": "C0022265",
"name": "13-cis-retinoic acid",
"pos": [
85,
105
]
} |
a gradual decrease in cell volume with age , combined with a constant haemoglobin concentration in the cells , indicates release of haemoglobin from the red cells during their lifespan . | NA | {
"id": "C0019016",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0019046",
"name": "haemoglobin",
"pos": [
132,
143
]
} |
estimation of heat-labile alkaline phosphatase isoenzyme in the serum of 45 healthy non-pregnant women and 98 women in the second and third trimesters of pregnancy revealed a statistically significant reduction of this isoenzyme during pregnancy . | NA | {
"id": "C0032981",
"name": "third trimesters",
"pos": [
134,
150
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
236,
245
]
} |
now that normal serum levels of the heat-labile alkaline phosphatase isoenzyme in pregnancy have been established it is possible to use estimations of the enzyme as part of the assessment of maternal liver function in pregnancy . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
69,
78
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
155,
161
]
} |
the increase in forearm blood flow induced by adrenaline , noradrenaline or angiotensin was significantly less in women treated for at least 6 weeks with clonidine compared with that induced in the women by infusions given before treatment . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
46,
56
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
59,
72
]
} |
the minimum inhibitory concentrations for erythromycin , clindamycin , lincomycin , tetracycline and minocycline have been determined for 92 clinical and three culture collection isolates of actinomyces . | NA | {
"id": "C0008947",
"name": "clindamycin",
"pos": [
57,
68
]
} | {
"id": "C0023726",
"name": "lincomycin",
"pos": [
71,
81
]
} |
when casein was reacted with caffeic acid at ph 7 in the presence of monophenol monooxygenase ( tyrosinase ; ec 1.14.18.1 ) , no chemical loss of tryptophan occurred , although fluorodinitrobenzene-reactive lysine fell by 23 % . | NA | {
"id": "C0041484",
"name": "monophenol",
"pos": [
69,
79
]
} | {
"id": "C0012524",
"name": "tyrosinase",
"pos": [
96,
106
]
} |
the assay was used to study the effect of the cu-antagonist molybdenum on the distribution of available cu in digesta from sheep given dried grass either untreated ( 1.6 mg mo/kg dry matter ( dm ) ) or treated with ammonium molybdate ( 11.6 mg mo/kg dm ) . | NA | {
"id": "C0026402",
"name": "molybdenum",
"pos": [
60,
70
]
} | {
"id": "C0051721",
"name": "ammonium molybdate",
"pos": [
215,
233
]
} |
effect of dietary protein concentration and ambient temperature on the energy , protein and water metabolism of the rat . | NA | {
"id": "C0012177",
"name": "dietary protein",
"pos": [
10,
25
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
80,
87
]
} |
protein-deficient weanling rats fed on a 30 g casein/kg diet for 3 weeks lost albumin but maintained the level of serum alpha-1-antitrypsin , the most abundant protease inhibitor in blood . alpha-1-antitrypsins from malnourished rats and control rats ( given 250 g casein/kg diet ) differed ; | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
0,
7
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
78,
85
]
} |
the amino sugar and neutral sugar contents of both preparations of alpha-1-antitrypsin were the same . | NA | {
"id": "C0002531",
"name": "amino sugar",
"pos": [
4,
15
]
} | {
"id": "C0007004",
"name": "sugar",
"pos": [
28,
33
]
} |
of these , in addition to the well-known hypertrophy of the pancreas attributable to dietary trypsin inhibitors , the observed atrophy of the thymus and the doubling in weight of the small intestine are related to the protein or lectin content of the bean diet , or both . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
218,
225
]
} | {
"id": "C0023206",
"name": "lectin",
"pos": [
229,
235
]
} |
in a previous study ( kindt et al . 1983 , 1984 ) it was assumed that a protein hydrolysate , devoid of phenylalanine , together with intact protein as given to children with phenylketonuria ( pku ) , was equivalent to egg or milk protein . | NA | {
"id": "C0033631",
"name": "protein",
"pos": [
72,
79
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
231,
238
]
} |
the purpose of the present study was to evaluate whether the quality of the protein hydrolysate , together with intact protein ( 'pku protein ' ) , is equivalent to egg or milk protein . | NA | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
76,
95
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
177,
184
]
} |
four protein sources were used : ( 1 ) egg protein , ( 2 ) protein hydrolysate , ( 3 ) protein hydrolysate diluted with non-essential amino acids , ( 4 ) protein hydrolysate mixed with food proteins ( 'pku protein ' ) , comparable with the diet previously used ( kindt et al . 1983 , 1984 ) . | NA | {
"id": "C0013700",
"name": "egg protein",
"pos": [
39,
50
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
206,
213
]
} |
four protein sources were used : ( 1 ) egg protein , ( 2 ) protein hydrolysate , ( 3 ) protein hydrolysate diluted with non-essential amino acids , ( 4 ) protein hydrolysate mixed with food proteins ( 'pku protein ' ) , comparable with the diet previously used ( kindt et al . 1983 , 1984 ) . | NA | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
59,
78
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
206,
213
]
} |
the protein hydrolysate alone and the protein hydrolysate diluted with non-essential amino acids gave a npu greater than 80 . | NA | {
"id": "C0033631",
"name": "protein",
"pos": [
4,
11
]
} | {
"id": "C0033684",
"name": "npu",
"pos": [
104,
107
]
} |
there were net losses of all amino acids across the forestomachs except for lysine , methione , d-alanine and d-glutamic acid for which there were net gains . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
29,
40
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
98,
105
]
} |
hmura was identified as the 2'-deoxyribonucleoside 5- ( hydroxymethyl ) -2'-deoxyuridine ( hmdu ) by subjecting the irradiated dna to enzymatic digestion and analyzing the mixture of 2'-deoxyribonucleosides by high-pressure liquid chromatography . | NA | {
"id": "C0011535",
"name": "deoxyuridine",
"pos": [
76,
88
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
186,
206
]
} |
those in 3t3-l1 fibroblasts were linear with an apparent kd of 0.48 nm and a receptor activity of 140 fmol/mg of cell protein for alpha 2m-ch3nh2 , an apparent kd of 0.29 nm and a receptor activity of 110 fmol/mg of cell protein for alpha 2m-pm , and an apparent kd of 0.35 nm and a receptor activity of 210 fmol/mg of c... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
16,
27
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
319,
323
]
} |
in biological and reconstituted membranes , preferential binding of phospholipid to the integral protein and exclusion of cholesterol in close vicinity of the membrane protein have been recognized . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
97,
104
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
159,
175
]
} |
on the basis of this work , it can be expected that flexible lipids readily accommodate the rough hydrophobic surface of integral proteins and stabilize the structure of the protein , while rigid lipids such as cholesterol are removed from the immediate environment of the membrane protein , if the protein does not inte... | NA | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
273,
289
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
299,
306
]
} |
at least one 2',5'-phosphodiester bond was important in forming each epitope , suggesting that the ribose phosphate backbone is a critical element in defining an antigenic domain of an oligonucleotide . | NA | {
"id": "C0003316",
"name": "epitope",
"pos": [
69,
76
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
162,
171
]
} |
the distribution of flavoproteins as revealed by the measurement of fad was different from that of nadph oxidase and cytochrome b , and followed the elution profile of nadh cytochrome c reductase . | NA | {
"id": "C0016223",
"name": "flavoproteins",
"pos": [
20,
33
]
} | {
"id": "C0068355",
"name": "nadph oxidase",
"pos": [
99,
112
]
} |
a mathematical model is presented which includes the following elementary process of mitochondrial energy transduction : hydrogen supply , proton translocation by the respiratory chain , proton-driven atp synthesis by the f0f1-atpase , passive back-flow of protons ( leak ) and carrier-mediated exchange of adenine nucle... | NA | {
"id": "C0013879",
"name": "elementary",
"pos": [
63,
73
]
} | {
"id": "C0020275",
"name": "hydrogen",
"pos": [
121,
129
]
} |
by comparing standard curves made with the isolated proteins to the values obtained in the presence of various amounts of the membrane-protein complex , one can calculate the content of this peptide in the membrane . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
52,
60
]
} | {
"id": "C0025252",
"name": "membrane-protein",
"pos": [
126,
142
]
} |
the inhibitor of specific-mediated hexose transport , cytochalasin b was found to inhibit equally basal and stimulated 3-o-methyl-d-glucose uptake but there was a cytochalasin b-insensitive uptake component in excess of l-glucose uptake . | NA | {
"id": "C0010737",
"name": "cytochalasin b",
"pos": [
54,
68
]
} | {
"id": "C0010739",
"name": "cytochalasin",
"pos": [
163,
175
]
} |
this study is the first to show that the lateral diffusion coefficient of integral proteins in a native membrane varies as the membrane protein concentration . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
83,
91
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
127,
143
]
} |
in other hormone responsive systems , phorbol ester ( phorbol myristate acetate , pma ) , a tumor promoter , has been implicated in the regulation of various transport processes through the activation of protein kinase c and cytoskeletal protein phosphorylation . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
38,
51
]
} | {
"id": "C0039654",
"name": "pma",
"pos": [
82,
85
]
} |
synaptic plasma membrane mg2+-atpase and microsomal membrane ( ca2+ + mg2+ ) -atpase did not respond to the inhibitor . | NA | {
"id": "C0001477",
"name": "mg2",
"pos": [
25,
28
]
} | {
"id": "C0001473",
"name": "atpase",
"pos": [
78,
84
]
} |
the proportion of 18:1 or 18:2 in the c-2 position of phosphatidylcholine correlated with the proportion of the respective fatty acids in microsomal free unsaturated fatty acids which could be incorporated effectively , except for the group of clofibric acid-fed rats . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
123,
134
]
} | {
"id": "C0015688",
"name": "free",
"pos": [
149,
153
]
} |
the selectivity for palmitoyl-coa was particularly enhanced when the mixed acyl-coa substrate was presented to the microsomes in molar concentrations equivalent to the molar ratios of the fatty acids in position 2 of sn-phosphatidylcholine . | NA | {
"id": "C0030239",
"name": "palmitoyl-coa",
"pos": [
20,
33
]
} | {
"id": "C0001374",
"name": "acyl-coa",
"pos": [
75,
83
]
} |
this temperature dependence of rna release was confirmed for alpha 2u-globulin mrna by use of a recombinant dna probe . | NA | {
"id": "C0035668",
"name": "rna",
"pos": [
31,
34
]
} | {
"id": "C0035696",
"name": "mrna",
"pos": [
79,
83
]
} |
by contrast , the cysteinyldopa quinones decayed via an acid-catalysed unimolecular cyclisation involving the cysteine side chain to form a cyclic quinone-imine observed directly for the first time . | NA | {
"id": "C0010665",
"name": "cysteinyldopa",
"pos": [
18,
31
]
} | {
"id": "C0010654",
"name": "cysteine",
"pos": [
110,
118
]
} |
the addition of cysteine had little effect on cysteinyldopa quinone decay and did not prevent quinone-imine formation . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
16,
24
]
} | {
"id": "C0010665",
"name": "cysteinyldopa",
"pos": [
46,
59
]
} |
a significant fraction of the in vitro synthesized hexokinase attained a conformation characteristic of the native enzyme as judged by the observations that it could be immunoprecipitated by monoclonal antibodies recognizing the native enzyme but not by antibodies recognizing denatured hexokinase , and limited tryptic ... | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
191,
212
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
254,
264
]
} |
lipopolysaccharide labeled with fluorescein isothiocyanate ( fitc-lps ) was used to examine interactions between endotoxin and plasma membrane in isolated rat hepatocytes and mouse neuroblastoma nb41a3 cells . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
66,
69
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
113,
122
]
} |
the point of cleavage is usually marked by a basic pair of amino acids containing arginine . | NA | {
"id": "C0301714",
"name": "basic",
"pos": [
45,
50
]
} | {
"id": "C0003765",
"name": "arginine",
"pos": [
82,
90
]
} |
two of the canavanine-treated proteins ( albumin and transferrin ) which underwent marked changes in electrophoretic mobility were more sensitive than untreated proteins to proteolysis by staphylococcus aureus v8 proteinase . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
41,
48
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
161,
169
]
} |
the identification of these compounds allowed us to conclude that the metabolism of 2 alpha-hydroxyprogesterone is similar to that of progesterone in this cellular system . | NA | {
"id": "C0020387",
"name": "alpha-hydroxyprogesterone",
"pos": [
86,
111
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
134,
146
]
} |
the inhibitory effect was prevented by treating the cells with a monoclonal antibody , bf 26 , raised against renocortin , a lipocortin-like protein formed in rat kidney medulla interstitial cells in culture . | NA | {
"id": "C0103403",
"name": "renocortin",
"pos": [
110,
120
]
} | {
"id": "C0065042",
"name": "lipocortin",
"pos": [
125,
135
]
} |
hemin also inhibited purified phosphorylase b kinase , indicating that hemin concentrations above 10 microm markedly inhibit multiple protein kinases . | NA | {
"id": "C0031713",
"name": "phosphorylase b kinase",
"pos": [
30,
52
]
} | {
"id": "C0033640",
"name": "protein kinases",
"pos": [
134,
149
]
} |
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