text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the bile salts of ursodeoxycholic acid , glycoursodeoxycholic acid , tauroursodeoxycholic acid , chenodeoxycholic acid , glycochenodeoxycholic acid , and taurochenodeoxycholic acid were each found to inhibit pepsin proteolytic activity in vitro at various concentrations against the refined substrate n-apdt . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
97,
118
]
} | {
"id": "C0017903",
"name": "glycochenodeoxycholic acid",
"pos": [
121,
147
]
} |
the bile salts of ursodeoxycholic acid , glycoursodeoxycholic acid , tauroursodeoxycholic acid , chenodeoxycholic acid , glycochenodeoxycholic acid , and taurochenodeoxycholic acid were each found to inhibit pepsin proteolytic activity in vitro at various concentrations against the refined substrate n-apdt . | NA | {
"id": "C0008024",
"name": "chenodeoxycholic acid",
"pos": [
97,
118
]
} | {
"id": "C0039356",
"name": "taurochenodeoxycholic acid",
"pos": [
154,
180
]
} |
a total of 1,022 patients with hydatid disease were treated by surgical operations in our hospital , 201 of whom had lung echinococcosis . | NA | {
"id": "C0013502",
"name": "hydatid disease",
"pos": [
31,
46
]
} | {
"id": "C0013505",
"name": "lung echinococcosis",
"pos": [
117,
136
]
} |
the amino acid pattern , the plasma catecholamines , dopamine , noradrenaline and adrenaline , serotonin in plasma and platelets , and monoamine oxidase ( mao ) b-activity in platelets were not different from controls . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
64,
77
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
82,
92
]
} |
in the controls , the levels of gaba , asp and glu in the brain increased , those of tau and gly decreased and those of pe , thr , ser , gln , ala and leu did not change during the experimental period . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
47,
50
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
137,
140
]
} |
after anoxic exposure the levels of gaba , tau , pe , asp , thr , glu , gln and ala , and the total free amino acid level in the brain decreased until the 7th day of life and thereafter rapidly increased . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
66,
69
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
72,
75
]
} |
in the controls , the gln level in csf was high , arg , asp and glu levels in csf were almost the same during infancy and childhood , and the levels of orn , lys , his , tau , thr , ser , asn , gly , ala , val , met , ile , leu , tyr and phe in csf decreased with age until pre-school age . | NA | {
"id": "C0017797",
"name": "gln",
"pos": [
22,
25
]
} | {
"id": "C0061472",
"name": "glu",
"pos": [
64,
67
]
} |
in the newborns and infants among the anoxic children , the levels of most free amino acids in csf were relatively high compared with those of the controls and , except glu and gln , decreased with age during infancy . | NA | {
"id": "C0061472",
"name": "glu",
"pos": [
169,
172
]
} | {
"id": "C0017797",
"name": "gln",
"pos": [
177,
180
]
} |
these results suggest that ethanol affects the gamma-aminobutyric acid-benzodiazepine receptor complex by changing release , metabolism , and/or excretion of an endogenous benzodiazepine ligand . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
125,
135
]
} | {
"id": "C0221102",
"name": "excretion",
"pos": [
145,
154
]
} |
glucose and acetaldehyde react covalently with albumin to form the post-translationally modified group of proteins , the glycosylated albumins and the acetaldehyde albumins , respectively . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
106,
114
]
} | {
"id": "C0001924",
"name": "albumins",
"pos": [
164,
172
]
} |
our results indicate that prolonged exposure of purified human serum albumin to acetaldehyde results in a major acetaldehyde albumin fraction that lacks the ability to bind madds and diazepam . | NA | {
"id": "C0304925",
"name": "human serum albumin",
"pos": [
57,
76
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
125,
132
]
} |
the data reported here suggest that ethanol-mediated increases in tissue prostaglandin ( pg ) e levels ( pge1 plus pge2 ) are correlated with the growth retardation . | NA | {
"id": "C0033559",
"name": "prostaglandin",
"pos": [
73,
86
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
115,
119
]
} |
to further characterize this drug-induced enzyme inhibition , erythrocyte aldehyde dehydrogenase activities were measured in patients undergoing therapy with nitrate ester antianginals ( isosorbide dinitrate and nitroglycerin ) and sulfonylurea hypoglycemics ( chlorpropamide and tolazamide ) . | NA | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
232,
244
]
} | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
280,
290
]
} |
drank a mean of 14 ounces of absolute alcohol and were otherwise comparable to the first group but stopped drinking in the second trimester , and never drank at all during pregnancy . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
123,
139
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
172,
181
]
} |
infants whose mothers stopped drinking in the second trimester were superior to those whose mothers continued to drink throughout pregnancy in observed state control , need for stimulation , motor tone , tremulousness , and asymmetries in reflexive behavior . | NA | {
"id": "C0032980",
"name": "second trimester",
"pos": [
46,
62
]
} | {
"id": "C0032961",
"name": "pregnancy",
"pos": [
130,
139
]
} |
a study has been undertaken to compare the induction characteristics of the new intravenous anaesthetic agent 2,6 di-isopropyl phenol , newly prepared in a lipid emulsion ( propofol ) with those of thiopentone . | NA | {
"id": "C0031428",
"name": "phenol",
"pos": [
127,
133
]
} | {
"id": "C0033487",
"name": "propofol",
"pos": [
173,
181
]
} |
a method for analyzing the carbohydrate composition of glycoproteins and similar glycoconjugates by methanolysis followed by reverse-phase high-pressure liquid chromatography of the perbenzoylated methyl glycosides has been developed . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
27,
39
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
81,
96
]
} |
a method for analyzing the carbohydrate composition of glycoproteins and similar glycoconjugates by methanolysis followed by reverse-phase high-pressure liquid chromatography of the perbenzoylated methyl glycosides has been developed . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
27,
39
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
204,
214
]
} |
a method for analyzing the carbohydrate composition of glycoproteins and similar glycoconjugates by methanolysis followed by reverse-phase high-pressure liquid chromatography of the perbenzoylated methyl glycosides has been developed . | NA | {
"id": "C0017968",
"name": "glycoproteins",
"pos": [
55,
68
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
81,
96
]
} |
selective removal of heparan sulfate chains from proteoheparan sulfate with a commercial preparation of heparitinase . | NA | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
21,
36
]
} | {
"id": "C0062503",
"name": "proteoheparan sulfate",
"pos": [
49,
70
]
} |
procedures employing the commercial preparation of heparitinase were developed for isolating a protein-enriched core molecule from proteoheparan sulfate by selective removal of the heparan sulfate chains . | NA | {
"id": "C0062503",
"name": "proteoheparan sulfate",
"pos": [
131,
152
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
181,
196
]
} |
a convenient method for the synthesis of a new selenium-containing amino acid , l-selenodjenkolate ( 3,3'-methylenediselenobis ( 2-aminopropionic acid ) ) , is described . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
67,
77
]
} | {
"id": "C0001898",
"name": "2-aminopropionic acid",
"pos": [
129,
150
]
} |
a foreign protein , sheep albumin , was injected into the ventricles at days 14e , 16e , 18e , 20e and on the day of birth . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
10,
17
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
26,
33
]
} |
after the foreign albumin had been left within the ventricle for several hours , some of the cells of the cortical plate also contained the protein , again mimicking the normal distribution of albumin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
140,
147
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
193,
200
]
} |
there were significant differences between diabetics and controls in the levels of threonine , serine , glutamine , glycine , iso-leucine , leucine , tyrosine , phenylalanine , histidine and in 3-methyl-histidine . | NA | {
"id": "C0019602",
"name": "histidine",
"pos": [
177,
186
]
} | {
"id": "C0025780",
"name": "methyl-histidine",
"pos": [
196,
212
]
} |
this method allowed for the detection of serum sufentanil in the terminal elimination phase of sufentanil in a patient receiving 1.5 micrograms/kg and will allow for studies to determine the pharmacokinetics and metabolism of sufentanil in a wide variety of patient groups now receiving this agent . | NA | {
"id": "C0221102",
"name": "elimination",
"pos": [
74,
85
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
212,
222
]
} |
tricuspid regurgitation is generally a functional disorder , and frequently occurs in association with left sided valvular heart disease , cardiomyopathy or congenital heart disease . | NA | {
"id": "C0040961",
"name": "tricuspid regurgitation",
"pos": [
0,
23
]
} | {
"id": "C0018824",
"name": "valvular heart disease",
"pos": [
114,
136
]
} |
a total of 594 patients admitted for cerebrovascular disease ( cvd ) and for peripheral vascular disease ( pvd ) , were examined in a study aimed at clarifying by a simple , inexpensive out-patient method , a ) the relationship existing between the different locations of the vascular disease : brain , lower limbs , cor... | NA | {
"id": "C0085096",
"name": "peripheral vascular disease",
"pos": [
77,
104
]
} | {
"id": "C0042373",
"name": "vascular disease",
"pos": [
276,
292
]
} |
kallikrein , prekallikrein , factor xia-like activity , and high molecular weight kininogen antigen were found in bal of patients with ards , suggesting that the kallikrein-kinin cascade may be activated in the lungs of patients with ards . | NA | {
"id": "C0033024",
"name": "prekallikrein",
"pos": [
13,
26
]
} | {
"id": "C0022478",
"name": "kallikrein",
"pos": [
162,
172
]
} |
our results indicated that hdp solutions between 2.76 and 22.10 mg/ml ( histamine base , 1 to 8 mg/ml ) show no evidence of degradation over a 4-month period when kept at 12 degrees c , unless gas sterilization techniques were used in preparing the solutions bacterial contamination was frequent , and at lower concentra... | NA | {
"id": "C0019588",
"name": "histamine",
"pos": [
72,
81
]
} | {
"id": "C0062740",
"name": "hdp",
"pos": [
365,
368
]
} |
exogenous sns response was assessed as change in plasma epinephrine and norepinephrine concentrations from basal levels during inhalation challenge . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
56,
67
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
72,
86
]
} |
neither plasma epinephrine nor norepinephrine increased significantly from basal concentrations in normal or asthmatic subjects after maximal challenge ( p greater than 0.33 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
15,
26
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
31,
45
]
} |
physicians should consider the possibility of primary htlv-iii infection when evaluating patients who belong to one of the risk groups for the acquired immunodeficiency syndrome and who have prolonged febrile illnesses . | NA | {
"id": "C0019693",
"name": "htlv-iii infection",
"pos": [
54,
72
]
} | {
"id": "C0001175",
"name": "acquired immunodeficiency syndrome",
"pos": [
143,
177
]
} |
overweight ( weight greater than 110 % ) nonsmoking men in the framingham study had 30-year mortality rates up to 3.9 higher than men of desirable weight ( weight , 100 % to 109 % ) . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
0,
10
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
156,
162
]
} |
although several risk factors for heart disease including high blood pressure , diabetes mellitus , and lipid and lipoprotein abnormalities are associated with overweight , overweight is not consistently associated with coronary heart disease risk . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
104,
109
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
114,
125
]
} |
although the health hazards due to excessive obesity and excessive leanness are multiple and diverse , weight recommendations for over 40 years have been based solely on the risk of dying . | NA | {
"id": "C0039870",
"name": "leanness",
"pos": [
67,
75
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
103,
109
]
} |
death rates for overweight and underweight persons were compared with rates for persons of average weight . | NA | {
"id": "C0497406",
"name": "overweight",
"pos": [
16,
26
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
99,
105
]
} |
prospective epidemiologic studies in men and women have shown that abdominal obesity is associated with increased risk for ischemic heart disease , stroke , and death independent of the total degree of obesity . | NA | {
"id": "C0311277",
"name": "abdominal obesity",
"pos": [
67,
84
]
} | {
"id": "C0028754",
"name": "obesity",
"pos": [
202,
209
]
} |
these data confirm the previously reported increasing trimethoprim-sulfamethoxazole resistance which is probably plasmid-mediated and specify the resistances associated with trimethoprim-sulfamethoxazole resistance . | NA | {
"id": "C0038689",
"name": "sulfamethoxazole",
"pos": [
67,
83
]
} | {
"id": "C0041044",
"name": "trimethoprim-sulfamethoxazole",
"pos": [
174,
203
]
} |
in the second experiment , increasing the zinc level with the diet ( 70 g crude protein from egg albumin ) from 11.6 to 300 mg/kg dry matter restored the zincaemia either in the high protein group ( 140 g crude protein/kg dry matter ) or in the low protein group ( 70 g crude protein/kg dry matter ) . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
97,
104
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
276,
283
]
} |
a 58 year old woman with cushing 's disease was admitted to hospital for acute ischaemia of the lower limbs due to fulminant streptococcal gangrene ( necrosing fasciitis ) . | NA | {
"id": "C0238124",
"name": "streptococcal gangrene",
"pos": [
125,
147
]
} | {
"id": "C0015645",
"name": "fasciitis",
"pos": [
160,
169
]
} |
four serum enzymes and isoenzymes used in the diagnosis of acute myocardial infarction ( ami ) , lactate dehydrogenase ld and ld-1 , creatine kinase ( ck ) , and ck-mb have been adapted to the technicon ra-1000 automated clinical chemistry analyzer . | NA | {
"id": "C0014442",
"name": "enzymes",
"pos": [
11,
18
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
23,
33
]
} |
on the contrary , with the exception of the aminosugars glucosamine , galactosamine , and mannosamine , increased attachment of candida to vaginal epithelial cells was found in the presence of dextrose , galactose , mannose , alpha-methyl-mannoside , n-acetyl-glucosamine , n-acetyl-galactosamine , and n-acetyl-mannosam... | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
56,
67
]
} | {
"id": "C0001056",
"name": "n-acetyl-glucosamine",
"pos": [
251,
271
]
} |
serum pepsinogen a ( pepsinogen i ) levels and urinary pepsinogen a phenotypes were studied in relation to abo blood group , age and sex in 700 healthy blood donors . | NA | {
"id": "C0077923",
"name": "pepsinogen i",
"pos": [
21,
33
]
} | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
55,
65
]
} |
this study was designed to evaluate the influence of a vlcd on lipids and lipoproteins , especially on hdl subfractions ( hdl2 , hdl3 ) in obese women . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
63,
69
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
74,
86
]
} |
a solid-phase sandwich enzyme immunoassay for human chorionic gonadotropin ( hcg ) employing monoclonal antibodies directed against beta- and alpha-subunits is described . | NA | {
"id": "C0018062",
"name": "human chorionic gonadotropin",
"pos": [
46,
74
]
} | {
"id": "C0017963",
"name": "alpha-subunits",
"pos": [
142,
156
]
} |
all the plasmids determined the synthesis of aph ( 3 ' ) -- aminoglycoside phosphotransferase responsible for the in-vivo resistance of the strains containing it to neomycin and paromomycin . | NA | {
"id": "C0027603",
"name": "neomycin",
"pos": [
165,
173
]
} | {
"id": "C0030576",
"name": "paromomycin",
"pos": [
178,
189
]
} |
at the same time glucose completely inhibited oleandomycin biosynthesis when added either as an only carbohydrate component or in combination with galactose or fructose , while the presence of the other two monosaccharides did not prevent antibiotic production , though the mycelium productivity was lowered as compared ... | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
101,
113
]
} | {
"id": "C0026492",
"name": "monosaccharides",
"pos": [
207,
222
]
} |
in the first series of the experiments it was shown that under the action of ultrasound such antibiotics as benzylpenicillin , streptomycin , ampicillin , lincomycin , monomycin , rifampicin and gentamicin , and antiseptic drugs such as furacin , rivanol and iodinol did not change their antibacterial ( bacteriostatic a... | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
108,
124
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
142,
152
]
} |
in plaque reduction assays dhpg , acyclovir , fiac , and fmau were inhibitory to six herpes types 1 and 2 virus strains at concentrations of 0.2-2.4 microm . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
27,
31
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
34,
43
]
} |
in guinea pig vaginal infections , dhpg provided significantly greater inhibition of herpetic lesions than did acyclovir . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
35,
39
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
111,
120
]
} |
in a herpes type 2 infection model in mice , dhpg , and fmau were active at 5 mg/kg , whereas acyclovir and fiac showed no statistically significant effect at 80 mg/kg . | NA | {
"id": "C0017066",
"name": "dhpg",
"pos": [
45,
49
]
} | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
94,
103
]
} |
the antiviral effect of acyclovir ( acv ; 9- ( 2-hydroxyethoxymethyl ) guanine ) on the replication of channel catfish virus ( ccv ) , a poikilothermic herpesvirus , in brown bullhead cells ( bb ) was studied in vitro . | NA | {
"id": "C0001367",
"name": "acyclovir",
"pos": [
24,
33
]
} | {
"id": "C0018321",
"name": "guanine",
"pos": [
71,
78
]
} |
the effects of three other antiviral agents , adenine-beta-d-arabinofuranoside ( ara-a ) , phosphonoacetic acid ( paa ) , and phosphonoformic acid ( pfa ) on ccv replication were evaluated either individually or in combination with acv . | NA | {
"id": "C0031681",
"name": "phosphonoacetic acid",
"pos": [
91,
111
]
} | {
"id": "C0070895",
"name": "phosphonoformic acid",
"pos": [
126,
146
]
} |
the results indicated that interactions with acv with ara-a , pfa and paa were primarily additive . | NA | {
"id": "C0070895",
"name": "pfa",
"pos": [
62,
65
]
} | {
"id": "C0031681",
"name": "paa",
"pos": [
70,
73
]
} |
in addition , one monoclonal antibody ( bef29 ) reacts strongly with cytochrome p-450f , and another antibody ( bea33 ) reacts weakly with cytochrome p-450a . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
18,
28
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
101,
109
]
} |
this result suggests that electrolytes decrease the activity coefficient of the dipolar ions , a salting-in phenomenon . | NA | {
"id": "C0013832",
"name": "electrolytes",
"pos": [
26,
38
]
} | {
"id": "C0022023",
"name": "ions",
"pos": [
88,
92
]
} |
the role of vitamin d metabolites in the regulation of hepatic 25-hydroxyvitamin d production was investigated by examining the effects of 25-hydroxyvitamin d , 1,25-dihydroxyvitamin d , and 24,25-dihydroxyvitamin d on the synthesis of [ 25-3h ] hydroxyvitamin d by rachitic rat liver homogenates . | NA | {
"id": "C0012328",
"name": "dihydroxyvitamin d",
"pos": [
166,
184
]
} | {
"id": "C0020337",
"name": "hydroxyvitamin d",
"pos": [
246,
262
]
} |
in addition to glutamate , mitochondrial ggt used 5-hydroxytryptophan , tryptophan , and cysteine as amino donors in the transamination to glyoxylate . | NA | {
"id": "C0000578",
"name": "5-hydroxytryptophan",
"pos": [
50,
69
]
} | {
"id": "C0041249",
"name": "tryptophan",
"pos": [
72,
82
]
} |
other phosphorylated sugars tested , glucosamine-6-p , n-acetylglucosamine-6-p , galactose-6-p , fructose-6-p , ribose-5-p , and arabinose-5-p , do not affect the rate of the reaction when assayed in the presence of mannose-6-32p . | NA | {
"id": "C0017718",
"name": "glucosamine",
"pos": [
37,
48
]
} | {
"id": "C0001056",
"name": "n-acetylglucosamine",
"pos": [
55,
74
]
} |
this alternate route may be the reason that i-cell fibroblasts contain a normal level of lysosomal acid phosphatase . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
46,
50
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
51,
62
]
} |
we measured concentrations of 5-fu in cancerous and normal cervical tissues in 16 patients with cervical cancer to whom uft or tegafur had been administered . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
32,
34
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
127,
134
]
} |
the results were as follows : concentrations of 5-fu in cancerous tissues measured 30 minutes and 2 hours after uft administration were 0.181 +/- 0.034 microgram/g and 0.562 +/- 0.145 micrograms/g respectively , while in patients to whom tegafur had been administered , they were 0.105 +/- 0.030 microgram/g and 0.126 +/... | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
50,
52
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
238,
245
]
} |
the comparison of 5-fu concentrations in cancerous tissues within each individual patient indicated that the value was higher after uft administration than after tegafur administration in 13 cases ( 81.3 % ) . | NA | {
"id": "C0016360",
"name": "fu",
"pos": [
20,
22
]
} | {
"id": "C0016778",
"name": "tegafur",
"pos": [
162,
169
]
} |
these data did not support recent suggestions that patients with these diseases showed exaggerated immunological responses to either virus and emphasised the need to incorporate adequate laboratory and disease controls when seroepidemiological studies are performed on sera containing rheumatoid factors and autoantibodi... | NA | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
285,
303
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
308,
322
]
} |
a rabbit antiserum against the major internal protein , p27 , of a psoriasis associated retrovirus-like particle has been applied in an immunofluorescence assay for the detection of antigens cross reacting with p27 in patients with psoriatic arthritis , seronegative rheumatoid arthritis , or ankylosing spondylitis . | NA | {
"id": "C0033860",
"name": "psoriasis",
"pos": [
67,
76
]
} | {
"id": "C0003872",
"name": "psoriatic arthritis",
"pos": [
232,
251
]
} |
diagnoses included non-hodgkin 's lymphoma ( 15 patients ) , t-cell lymphoma ( 2 ) , acute lymphoblastic leukemia ( 3 ) , hodgkin 's disease ( 1 ) , and breast cancer ( 1 ) . | NA | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
19,
42
]
} | {
"id": "C0079772",
"name": "t-cell lymphoma",
"pos": [
61,
76
]
} |
when superimposed on regional ischemia , global ischemia resulted in a 6-fold increase in infarct size after 15 minutes of coronary occlusion ( p less than 0.05 ) , a 2.2-fold increase after 30 minutes of coronary occlusion ( p less than 0.05 ) , and no significant increase after 60 minutes of coronary occlusion . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
30,
38
]
} | {
"id": "C0021308",
"name": "infarct",
"pos": [
90,
97
]
} |
reperfusion prior to global ischemia completely prevented infarct extension with 0.4 % less infarction ( not significant ) in this group versus the controls without global ischemia . | NA | {
"id": "C0021308",
"name": "infarction",
"pos": [
92,
102
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
172,
180
]
} |
these results clearly demonstrate that infarct extension occurring when global ischemia is superimposed on regional ischemia is greatest early in infarct evolution but that reflow to the region at risk before global ischemic arrest prevents the additional infarction . | NA | {
"id": "C0022116",
"name": "ischemia",
"pos": [
79,
87
]
} | {
"id": "C0021308",
"name": "infarction",
"pos": [
256,
266
]
} |
spermatozoa were able to activate pmn in the presence of heat-inactivated serum ( only antibody , no complement ) , serum obtained from a patient with agammaglobulinemia ( without antibodies and only complement as opsonin ) , and in mgegta agammaglobulinemic serum ( only the alternative pathway of complement intact ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
180,
190
]
} | {
"id": "C0029122",
"name": "opsonin",
"pos": [
214,
221
]
} |
this study reports data on metabolic parameters of human spermatozoa in the presence of a met-enkephalin analogue : d-ala2-mephe4-met- ( o ) -ol-enkephalin , fk 33824 , sandoz , basel , switzerland ( damme ) , and its receptor antagonist naloxone hydrochloride , endo laboratories , garden city , new york . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
90,
104
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
145,
155
]
} |
this study reports data on metabolic parameters of human spermatozoa in the presence of a met-enkephalin analogue : d-ala2-mephe4-met- ( o ) -ol-enkephalin , fk 33824 , sandoz , basel , switzerland ( damme ) , and its receptor antagonist naloxone hydrochloride , endo laboratories , garden city , new york . | NA | {
"id": "C0014295",
"name": "met-enkephalin",
"pos": [
90,
104
]
} | {
"id": "C0949300",
"name": "damme",
"pos": [
200,
205
]
} |
effects of nine choline ethers , ( ch3 ) 3 nch2ch ( r ) -o-r ' , on the muscarinic and nicotinic receptors of longitudinal smooth muscle of guinea-pig ileum were studied to understand the role of electronic/steric factors at the ether-oxygen in stimulating the cholinergic receptors . | NA | {
"id": "C0034830",
"name": "nicotinic receptors",
"pos": [
87,
106
]
} | {
"id": "C0034792",
"name": "cholinergic receptors",
"pos": [
261,
282
]
} |
in incubation experiments with 3h-adrenaline , formation of metanephrine was inhibited , neuronal uptake and oxidative deamination remaining unaffected . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
34,
44
]
} | {
"id": "C0025562",
"name": "metanephrine",
"pos": [
60,
72
]
} |
the hemodynamic effects of the dihydropyridine-derivative bay k 8644 ( methyl-1,4-dihydro-2 , 6-dimethyl-3-nitro-4- ( 2-trifluoro-methylphenyl ) -pyridine-5-carboxylate ) , a chemical analogue of nifedipine , were evaluated in 9 conscious , chronically instrumented dogs . | NA | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
31,
46
]
} | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
196,
206
]
} |
despite diffuse disease of the lungs ( often with widespread inflammation or obliteration of blood vessels ) in sarcoidosis , pulmonary hypertension is uncommon , occurring in 1 % to 4 % of cases . | NA | {
"id": "C0024115",
"name": "disease of the lungs",
"pos": [
16,
36
]
} | {
"id": "C0020542",
"name": "pulmonary hypertension",
"pos": [
126,
148
]
} |
the placental receptor has a high content of acidic amino acids and a relatively low number of aromatic and hydrophobic amino acid residues . | NA | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
45,
63
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
120,
130
]
} |
a prospective series comprising 52 knees in 48 patients suffering from medial or lateral unicompartmental gonarthrosis and treated by means of high tibial osteotomy shows , by comparing mechanical axis ( ma ) 0 degrees corrected knees , how important is the overcorrection of the ma into valgus in medial osteoarthritis ... | NA | {
"id": "C0409959",
"name": "gonarthrosis",
"pos": [
106,
118
]
} | {
"id": "C0029408",
"name": "osteoarthritis",
"pos": [
305,
319
]
} |
daily postoperative nitrogen balance , fractional albumin renewal rate , and whole-body tyrosine appearance , oxidation , and incorporation into protein were not significantly different among the three groups . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
50,
57
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
145,
152
]
} |
a diet containing only branched-chain amino acids in isomolar ratios was as effective at maintaining protein retention and whole-body protein synthesis and albumin renewal postoperatively when compared with a standard amino acid formula . | NA | {
"id": "C0002521",
"name": "branched-chain amino acids",
"pos": [
23,
49
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
218,
228
]
} |
when a polyester antimicrobial incise drape ( loban 2 antimicrobial film ) was applied to an operative area after a one-minute skin preparation using either 70 % alcohol or 2 % iodine in 90 % alcohol , the clean wound infection rate ( 1.3 % ) and overall wound infection rate ( 2.5 % ) were comparable to those following... | NA | {
"id": "C0009450",
"name": "infection",
"pos": [
218,
227
]
} | {
"id": "C0043241",
"name": "wound infection",
"pos": [
255,
270
]
} |
the hydrolysis of vinyl acetate ( formation of acetic acid ) has been studied in vitro with rat liver and lung microsomes , rat and human plasma and purified esterases ( such as acetylcholine esterase , butyrylcholine esterase , carboxyl esterase ) . | NA | {
"id": "C0001044",
"name": "acetylcholine esterase",
"pos": [
178,
200
]
} | {
"id": "C0008429",
"name": "butyrylcholine esterase",
"pos": [
203,
226
]
} |
the rate of increase in the renal cd content is dependent on the ratio of cd : zn in the injected metalloprotein , and is appreciably less when the constant dose of protein-bound cd is given as a ( 2.4 cd:1 zn ) mt , than as a ( 3.0 cd:1 zn ) mt . | NA | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
98,
112
]
} | {
"id": "C0025545",
"name": "mt",
"pos": [
243,
245
]
} |
binding of cd2+ allowed cam to bind 2 moles chlorpromazine , or to form a complex with skeletal muscle troponin-i , troponin-t , or phosphodiesterase . | NA | {
"id": "C0041199",
"name": "troponin",
"pos": [
103,
111
]
} | {
"id": "C0077404",
"name": "troponin-t",
"pos": [
116,
126
]
} |
they consider that the cerebral hemorrhage must be related to the autoimmune disorders that occur in sle . | NA | {
"id": "C0004364",
"name": "autoimmune disorders",
"pos": [
66,
86
]
} | {
"id": "C0024141",
"name": "sle",
"pos": [
101,
104
]
} |
the presence of these atypical features in patients whose lower motor neuron involvement would otherwise be consistent with juvenile-onset spinal muscular atrophy should raise the suspicion of the presence of hexosaminidase-a deficiency and gm2 gangliosidosis that can be proved by appropriate enzyme assays . | NA | {
"id": "C0039373",
"name": "hexosaminidase-a deficiency",
"pos": [
209,
236
]
} | {
"id": "C0268274",
"name": "gm2 gangliosidosis",
"pos": [
241,
259
]
} |
these observations encourage radical treatment of the primary cancer in patients with advanced malignant neoplasms who are disabled by cerebellar dysfunction , and lend support to a current hypothesis that paraneoplastic cerebellar degeneration is due to anticerebellar purkinje cell antibodies elaborated by the primary... | NA | {
"id": "C0007760",
"name": "cerebellar dysfunction",
"pos": [
135,
157
]
} | {
"id": "C0393534",
"name": "paraneoplastic cerebellar degeneration",
"pos": [
206,
244
]
} |
specific cytoplasmic staining was seen both in explanted root-pulp tissues and in immature fibroblast-like pulp cells from monolayer cell cultures of bovine root pulps , which indicate that the pulp cells are responsible for inhibitor production . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
91,
101
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
using the chinchilla model of pneumococcal otitis media , significant snhl was demonstrated after purulent otitis media , especially at higher frequencies . | NA | {
"id": "C0029882",
"name": "otitis media",
"pos": [
43,
55
]
} | {
"id": "C0029888",
"name": "purulent otitis media",
"pos": [
98,
119
]
} |
chlorhexidine gluconate is a derivative of chlorhexidine and is a popular disinfectant with a strong bactericidal action that is widely used for preoperative sterilization in ear surgery . | NA | {
"id": "C0055361",
"name": "chlorhexidine gluconate",
"pos": [
0,
23
]
} | {
"id": "C0008196",
"name": "chlorhexidine",
"pos": [
43,
56
]
} |
immunohistochemical studies demonstrated that macrophages , fibroblasts and osteoclasts produced collagenase and prostaglandins in the bone resorption processes , suggesting that these cells are responsible for the resorption observed . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
60,
71
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
185,
190
]
} |
the uptake of acetate , 3-hydroxybutyrate , esterified fatty acids and plasma free fatty acids accounted for about 25 , 13 , 60 and 4 % of milk fatty acid carbon respectively , after correction for the oxidation of acetate , but not of the other substrates . | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
78,
94
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
144,
154
]
} |
it is proposed that the total metabolites of linoleic and linolenic acids are the most appropriate measure of the essential fatty acid status of the fetal lamb . | NA | {
"id": "C0023752",
"name": "linolenic acids",
"pos": [
58,
73
]
} | {
"id": "C0015686",
"name": "essential fatty acid",
"pos": [
114,
134
]
} |
the results demonstrated that the level of specific antibody in the serum of mice immunised with gliadin is markedly reduced when gluten is present in the diet on which the animals were raised . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
97,
104
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
130,
136
]
} |
the suppression of the antibody response to gliadin in the gluten-fed mice appeared to be antigen-specific , as std mice responded normally to unrelated antigens such as sheep red blood cells ( srbc ) . | NA | {
"id": "C0017622",
"name": "gliadin",
"pos": [
44,
51
]
} | {
"id": "C2362561",
"name": "gluten",
"pos": [
59,
65
]
} |
investigations failed to show any of the demonstrable causes of pancreatitis , but on family study four close paternal relatives were found to have had chronic pancreatitis , three with radiological calcification . | NA | {
"id": "C0030305",
"name": "pancreatitis",
"pos": [
64,
76
]
} | {
"id": "C0149521",
"name": "chronic pancreatitis",
"pos": [
152,
172
]
} |
in the arthrotomy group the synovial fluid hyaluronic acid concentration fell after surgery but it was unaffected by the injection of sodium hyaluronate . | NA | {
"id": "C0020196",
"name": "hyaluronic acid",
"pos": [
43,
58
]
} | {
"id": "C0087000",
"name": "sodium hyaluronate",
"pos": [
134,
152
]
} |
the ratio of the histidine dipeptides anserine and carnosine which are present in skeletal muscle , are so different between sheep , cattle , horse and kangaroo that detection of adulteration can be rapidly achieved by chromatography on a partisil-10 scx column with 0.2 m lithium formate , ph 2.9 . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
27,
37
]
} | {
"id": "C0003134",
"name": "anserine",
"pos": [
38,
46
]
} |
the ratio of the histidine dipeptides anserine and carnosine which are present in skeletal muscle , are so different between sheep , cattle , horse and kangaroo that detection of adulteration can be rapidly achieved by chromatography on a partisil-10 scx column with 0.2 m lithium formate , ph 2.9 . | NA | {
"id": "C0012512",
"name": "dipeptides",
"pos": [
27,
37
]
} | {
"id": "C0007267",
"name": "carnosine",
"pos": [
51,
60
]
} |
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