text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
by contrast , 5 microm hemin or less was sufficient to raise intracellular heme levels , as indicated by the relative heme-saturation of tryptophan oxygenase in hepatocytes . | NA | {
"id": "C0018988",
"name": "hemin",
"pos": [
23,
28
]
} | {
"id": "C0018966",
"name": "heme",
"pos": [
118,
122
]
} |
[ animal lipoxygenases . the nature of substrates and changes in conformation of reticulocyte lipoxygenase in its interaction with membranes ] . | NA | {
"id": "C2936592",
"name": "lipoxygenases",
"pos": [
9,
22
]
} | {
"id": "C0023837",
"name": "lipoxygenase",
"pos": [
94,
106
]
} |
clusterin , a glycoprotein that elicits cell aggregation , has previously been isolated from ram rete testis fluid , and has been partially characterized . | NA | {
"id": "C0055966",
"name": "clusterin",
"pos": [
0,
9
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
14,
26
]
} |
vasoactive intestinal peptide dose-dependently stimulated progesterone , 20 alpha-hydroxypregn-4-ene-3-one ( 20 alpha-oh-progesterone ) , and estrogen production with an approximate ed50 value of 3 x 10 ( -8 ) m . | NA | {
"id": "C0012311",
"name": "20 alpha-hydroxypregn-4-ene-3-one",
"pos": [
73,
106
]
} | {
"id": "C0033308",
"name": "progesterone",
"pos": [
121,
133
]
} |
the quantification in plasma and urine of 2-dicyclopropylmethylamino-2-oxazoline ( s-3341 ) , a new antihypertensive drug is described using a sensitive gas chromatographic negative ion mass spectrometric method with ammonia as moderating gas . | NA | {
"id": "C0002607",
"name": "ammonia",
"pos": [
217,
224
]
} | {
"id": "C0017110",
"name": "gas",
"pos": [
239,
242
]
} |
in these two patients , viral dna sequences were not detected in the plasma or platelet fraction , whereas the mononuclear cell dna contained small amounts of a 7.2 kb size unintegrated hepatitis b genome . | NA | {
"id": "C0012939",
"name": "viral dna",
"pos": [
24,
33
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
128,
131
]
} |
these results indicate that the human igm monoclonal anti-dna autoantibodies that express the dominant 16/6 idiotype are polyspecific , bind to platelets , and interact with a platelet epitope that does not appear to involve dna , protein , or sialic acid . | NA | {
"id": "C0021013",
"name": "idiotype",
"pos": [
108,
116
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
185,
192
]
} |
high-molecular weight dnas of fresh bone marrow cells from 32 patients with fresh leukemia were assayed for the presence of transmissible activated transforming genes by a dna-mediated gene transfer technique using nih/3t3 cells . | NA | {
"id": "C0012854",
"name": "dnas",
"pos": [
22,
26
]
} | {
"id": "C0000702",
"name": "a dna",
"pos": [
170,
175
]
} |
the metabolism of the main beta-adrenoceptor stimulants which are not catechol derivatives involves conjugation with glucuronic or sulphuric acids in several animal species and conjugation with sulphuric acid in man . | NA | {
"id": "C0038786",
"name": "sulphuric acids",
"pos": [
131,
146
]
} | {
"id": "C0038784",
"name": "sulphuric acid",
"pos": [
194,
208
]
} |
pretreatment with noradrenaline ( 0.5 and 1.0 nmol ) significantly increased the effect of hypothalamic stimulation on feeding , whereas injection of 1.0 , 2.0 and 4.0 nmol of adrenaline or dopamine was ineffective . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
18,
31
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
176,
186
]
} |
this paper reviews analytical techniques for the detection and identification of amphetamines and amphetamine-like substances in non-biological samples . | NA | {
"id": "C0002667",
"name": "amphetamines",
"pos": [
81,
93
]
} | {
"id": "C0002658",
"name": "amphetamine",
"pos": [
98,
109
]
} |
the effects of the co-carcinogenic phorbol ester , phorbol myristate acetate ( pma ) , on n-formyl-met-leu-phe ( fmlp ) -induced human polymorphonuclear leukocyte chemokinesis and release of granular lysozyme and beta-glucuronidase were compared with those of the inactive phorbol didecanoate ( pdd ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
35,
48
]
} | {
"id": "C0039654",
"name": "phorbol myristate acetate",
"pos": [
51,
76
]
} |
methionine enkephalin , leucine enkephalin , [ d-ala2 , d-leu5 ] enkephalin , alpha-neoendorphin , beta-endorphin , dynorphin ( 1-13 ) and ethylketocyclazocine inhibited the contractions of rabbit ear artery ring segments elicited by transmural nerve stimulation at 8 hz . | NA | {
"id": "C0014295",
"name": "methionine enkephalin",
"pos": [
0,
21
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
65,
75
]
} |
methionine enkephalin , leucine enkephalin , [ d-ala2 , d-leu5 ] enkephalin , alpha-neoendorphin , beta-endorphin , dynorphin ( 1-13 ) and ethylketocyclazocine inhibited the contractions of rabbit ear artery ring segments elicited by transmural nerve stimulation at 8 hz . | NA | {
"id": "C0014294",
"name": "leucine enkephalin",
"pos": [
24,
42
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
65,
75
]
} |
naloxone antagonized the actions of opioids and ethylketocyclazocine , and was more effective against methionine enkephalin , leucine enkephalin and [ d-ala2 , d-leu5 ] enkephalin than against alpha-neoendorphin , ethylketocyclazocine and dynorphin ( 1-13 ) . | NA | {
"id": "C0014295",
"name": "methionine enkephalin",
"pos": [
102,
123
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
169,
179
]
} |
naloxone antagonized the actions of opioids and ethylketocyclazocine , and was more effective against methionine enkephalin , leucine enkephalin and [ d-ala2 , d-leu5 ] enkephalin than against alpha-neoendorphin , ethylketocyclazocine and dynorphin ( 1-13 ) . | NA | {
"id": "C0014294",
"name": "leucine enkephalin",
"pos": [
126,
144
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
169,
179
]
} |
the effects of a 5'-substituted analogue of adenosine , 5'-n-ethylcarboxamidoadenosine ( neca ) have been studied on glucagon secretion in vitro , using the isolated pancreas of the rat perfused in the presence of glucose ( 2.8 mm ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
44,
53
]
} | {
"id": "C0050789",
"name": "5",
"pos": [
56,
57
]
} |
neca provoked a peak of glucagon secretion , the kinetics of which were comparable to those previously obtained with adenosine . | NA | {
"id": "C0050789",
"name": "neca",
"pos": [
0,
4
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
117,
126
]
} |
a comparison of relative potency between adenosine and neca showed that neca was about 800 fold more potent than adenosine in inducing glucagon secretion . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
41,
50
]
} | {
"id": "C0050789",
"name": "neca",
"pos": [
72,
76
]
} |
in view of the recent m1 and m2 subclassification of muscarinic receptors and the suggestion of separate populations of muscarinic receptors on oxyntic and histamine cells in the gastric mucosa , we have analysed the effects of mcn-a 343 , classified as an m1-selective agonist , on gastric acid secretion by the mouse ,... | NA | {
"id": "C0384752",
"name": "m2",
"pos": [
29,
31
]
} | {
"id": "C0034826",
"name": "muscarinic receptors",
"pos": [
120,
140
]
} |
ablations in the cns included pithing , spinalization and decerebration combined with acute and chronic surgical preparation and noradrenaline/adrenaline infusions . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
129,
142
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
143,
153
]
} |
cholinoceptor agonists ( arecoline congruent to carbachol greater than acetylcholine greater than pilocarpine ) potentiated contractions to field stimulation of rat vas deferens via the activation of an atropine-sensitive muscarinic receptor . | NA | {
"id": "C3536927",
"name": "cholinoceptor agonists",
"pos": [
0,
22
]
} | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
98,
109
]
} |
pge-analogues were the most potent compounds , the rank order of potency being 16 , 16 dimethyl pge2 greater than pge2 greater than pgf2 alpha greater than u-46619 greater than pgd2 greater than pgi2 . | NA | {
"id": "C0033559",
"name": "pge",
"pos": [
0,
3
]
} | {
"id": "C0012472",
"name": "pge2",
"pos": [
114,
118
]
} |
the motor disorder of 100 patients with severe psychiatric illness is described and the contribution of previous treatment , hospitalization and possible neurological disorder is considered . | NA | {
"id": "C0221163",
"name": "motor disorder",
"pos": [
4,
18
]
} | {
"id": "C0004936",
"name": "psychiatric illness",
"pos": [
47,
66
]
} |
the conflict of paradigms between the concept that this motor disorder has two distinct aetiologies , psychiatric and neurological , and the concept that both motor and mental disorder are an expression of underlying cerebral disorder is discussed . | NA | {
"id": "C0221163",
"name": "motor disorder",
"pos": [
56,
70
]
} | {
"id": "C0004936",
"name": "mental disorder",
"pos": [
169,
184
]
} |
bleeding from the tumour was detected in two cases and the extent of each haematoma was precisely determined by ct . | NA | {
"id": "C0019080",
"name": "bleeding",
"pos": [
0,
8
]
} | {
"id": "C0018944",
"name": "haematoma",
"pos": [
74,
83
]
} |
plasma testosterone , oestradiol , luteinising hormone ( lh ) growth hormone and prolactin were measured serially in 140 patients with advanced prostatic carcinoma ( t3 , t4 , mi and mo ) randomised in a trial of diethylstilboestrol 3 mg/day against estramustine 560 mg/day . | NA | {
"id": "C0014912",
"name": "oestradiol",
"pos": [
22,
32
]
} | {
"id": "C0014921",
"name": "estramustine",
"pos": [
250,
262
]
} |
the total adenine nucleotide pool , phosphocreatine , creatine and glycogen were decreased before tpn , and only glycogen returned to normal after tpn compared with controls . | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
36,
51
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
54,
62
]
} |
in many patients who develop epilepsy the disease is short lived and the overall number of seizures small . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
29,
37
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
91,
99
]
} |
stilboestrol increased supine plasma renin and angiotensin ii values but the response of renin-angiotensin-aldosterone activity to erect posture was progressively reduced during treatment . | NA | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
47,
61
]
} | {
"id": "C0003018",
"name": "angiotensin",
"pos": [
95,
106
]
} |
to quantitate cell proliferation in the infarcts from 12 h to 25 days after ischemia , gerbils were injected with [ 3h ] thymidine 4 h prior to sacrifice , and autoradiographs were prepared from sectioned brains . | NA | {
"id": "C0021308",
"name": "infarcts",
"pos": [
40,
48
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
76,
84
]
} |
horseradish peroxidase conjugates of either the lectin wheat germ agglutinin ( wga-hrp ) or choleragenoid ( b-hrp ) have been shown to be sensitive neuroanatomical tracers . | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
79,
86
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
110,
113
]
} |
injection of wga-hrp resulted in labeling of predominantly small cell bodies , whereas b-hrp gave rise to labeling of somewhat larger cell bodies . | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
13,
20
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
89,
92
]
} |
by increasing the concentration of the injected wga-hrp solution the number of labeled cells increased substantially , while a corresponding increase in the concentration of b-hrp resulted in a relatively small increase in the number of labeled cells . | NA | {
"id": "C0078473",
"name": "wga-hrp",
"pos": [
48,
55
]
} | {
"id": "C0019941",
"name": "hrp",
"pos": [
176,
179
]
} |
thus , low doses of the drug may preferentially activate inhibitory presynaptic serotonin receptors ( autoreceptors ) , decrease serotonin metabolism and thereby increase feeding . | NA | {
"id": "C0206129",
"name": "presynaptic",
"pos": [
68,
79
]
} | {
"id": "C0206128",
"name": "autoreceptors",
"pos": [
102,
115
]
} |
biochemical and electrophysiological studies of mammalian cns indicate that the amino-acid , glycine , is a major inhibitory neurotransmitter whose location is , for the large part , confined to the spinal cord and brain stem . | NA | {
"id": "C0002520",
"name": "amino-acid",
"pos": [
80,
90
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
93,
100
]
} |
dense quiescent cultures of chick embryo fibroblasts infected by ny 68 virus ( ts mutant for transformation of rous sarcoma virus ) were stimulated to proliferate either by addition of growth factors in cultures maintained at 41 degrees c or by expression of transformation ( by the cell transfer from 41 to 37 degrees c... | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
41,
52
]
} | {
"id": "C0007634",
"name": "cell",
"pos": [
283,
287
]
} |
bilirubin ( an albumin ligand ) has no effect on albumin modulation of platelet response until the bilirubin/protein ratio exceeds 2 . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
15,
22
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
109,
116
]
} |
both activator protein and albumin bind to the monomeric form of gm2 ganglioside and not to the micellar form of the substrate . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
15,
22
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
27,
34
]
} |
in one of these , it was shown that the subcellular distribution of exogenously added porcine insulin or porcine 125i-labeled insulin was different from the distribution of endogenous insulin . | NA | {
"id": "C0724601",
"name": "porcine",
"pos": [
86,
93
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
184,
191
]
} |
the plasma lipoproteins are large spherical macromolecular structures containing hydrophobic core lipids with phospholipids , cholesterol , and specific proteins ( apoproteins ) providing an amphipathic interface with the hydrophilic environment of the plasma . | NA | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
11,
23
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
117,
123
]
} |
the plasma lipoproteins are large spherical macromolecular structures containing hydrophobic core lipids with phospholipids , cholesterol , and specific proteins ( apoproteins ) providing an amphipathic interface with the hydrophilic environment of the plasma . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
15,
23
]
} | {
"id": "C0003601",
"name": "apoproteins",
"pos": [
164,
175
]
} |
the nature and mass ratios of these surface lipids are themselves dependent upon the activity of apoprotein-stimulated catabolic enzymes and other proteins which mediate the exchange of surface lipids between lipoprotein particles . | NA | {
"id": "C0003601",
"name": "apoprotein",
"pos": [
97,
107
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
147,
155
]
} |
the nature and mass ratios of these surface lipids are themselves dependent upon the activity of apoprotein-stimulated catabolic enzymes and other proteins which mediate the exchange of surface lipids between lipoprotein particles . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
44,
50
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
209,
220
]
} |
the most completely characterized lipoprotein receptor is the ldl ( low density lipoprotein ) or apo-b , e ( ldl ) receptor . | NA | {
"id": "C0065059",
"name": "lipoprotein",
"pos": [
34,
45
]
} | {
"id": "C0034821",
"name": "ldl",
"pos": [
109,
112
]
} |
the distribution of antigenic determinants recognized by mabs has been studied on the hepatic ( apo b-100 ) and intestinal ( apo b-48 ) forms of apo b and on fragments generated by limited proteolysis of apo b . | NA | {
"id": "C0205666",
"name": "apo",
"pos": [
96,
99
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
204,
209
]
} |
the distribution of antigenic determinants recognized by mabs has been studied on the hepatic ( apo b-100 ) and intestinal ( apo b-48 ) forms of apo b and on fragments generated by limited proteolysis of apo b . | NA | {
"id": "C0103839",
"name": "apo b-48",
"pos": [
125,
133
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
204,
209
]
} |
apo b-100 specific mabs coupled to sepharose have been used to isolate separately apo-b-containing lipoproteins of intestinal and hepatic origin and their respective lipid and apolipoprotein compositions have been determined . | NA | {
"id": "C0205666",
"name": "apo b-100",
"pos": [
0,
9
]
} | {
"id": "C0003593",
"name": "apo-b",
"pos": [
82,
87
]
} |
apo b-100 specific mabs coupled to sepharose have been used to isolate separately apo-b-containing lipoproteins of intestinal and hepatic origin and their respective lipid and apolipoprotein compositions have been determined . | NA | {
"id": "C0003593",
"name": "apo-b",
"pos": [
82,
87
]
} | {
"id": "C0003591",
"name": "apolipoprotein",
"pos": [
176,
190
]
} |
less than 9 % of the variation in lipid or lipoprotein levels was related to age or relative body weight . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
34,
39
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
43,
54
]
} |
the new derivative epirubicin ( 4'-epidoxorubicin ) is already available clinically as a better tolerated drug , with confirmed efficacy on doxorubicin responsive diseases . | NA | {
"id": "C0014582",
"name": "4",
"pos": [
32,
33
]
} | {
"id": "C0013089",
"name": "doxorubicin",
"pos": [
140,
151
]
} |
the 12-o-tetradecanoylphorbol-13-acetate treatment had this same effect on burkitt 's lymphoma cells ( raji or namalwa ) but the opposite effect on normal cells ( epstein-barr virus-immortalized lymphocytes or fetal fibroblasts ) where it enhanced the formation of ta-dna transcripts up to the levels found in untreated ... | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
216,
227
]
} |
the interaction of photodynamic therapy ( pdt ) and hyperthermia was studied in the radiation-induced-fibrosarcoma experimental mouse tumor system by tumor regrowth experiments as well as in vivo to in vitro cloning assays . | NA | {
"id": "C0027666",
"name": "radiation-induced",
"pos": [
84,
101
]
} | {
"id": "C0027651",
"name": "tumor",
"pos": [
150,
155
]
} |
there appeared to be two categories of cell types based on rh-123 uptake : those which progressively accumulate the dye , such as ehrlich ascites tumor cells , carcinoma-derived lines mcf-7 , paca-2 , ej , hela , and normal fibroblast line ccl 64 ; | NA | {
"id": "C0007125",
"name": "ehrlich ascites tumor",
"pos": [
130,
151
]
} | {
"id": "C0007097",
"name": "carcinoma",
"pos": [
160,
169
]
} |
on the other hand , lacto-series gangliosides , with longer sugar moieties increased with a concomitant decrease in ganglio-series ganglioside gm3 , and the ganglioside profile became more complex . | NA | {
"id": "C0016897",
"name": "ganglioside gm3",
"pos": [
131,
146
]
} | {
"id": "C0017082",
"name": "ganglioside",
"pos": [
157,
168
]
} |
however , as determined by absorption experiments , the majority of antibodies in each antiserum are directed against the respective synthetic peptide , and only a small portion are reactive with native immunoglobulin m . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
68,
78
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
87,
96
]
} |
diversity of human pancreatic cancer cell proteinases : role of cell membrane metalloproteinases in collagenolysis and cytolysis . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
42,
53
]
} | {
"id": "C0025543",
"name": "metalloproteinases",
"pos": [
78,
96
]
} |
total plasminogen activator ( pa ) activity , tissue-type pa ( t-pa ) activity , urokinase-like pa activity , and immunoreactive t-pa were measured in benign breast tumors ( fibroadenomas ) , primary breast carcinomas , axillary node metastases , and chest wall recurrences . | NA | {
"id": "C0032143",
"name": "tissue-type pa",
"pos": [
46,
60
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
131,
133
]
} |
both t-pa activity and immunoreactive t-pa were significantly lower in chest wall recurrences compared with primary carcinomas . | NA | {
"id": "C0032143",
"name": "t-pa",
"pos": [
5,
9
]
} | {
"id": "C0032144",
"name": "pa",
"pos": [
97,
99
]
} |
other thiols like cysteamine , namely cysteine , n-acetylcysteine , and dithiothreitol , were found to be similar in their potential to induce gsh elevation in chinese hamster ovary cells . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
38,
46
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
49,
65
]
} |
three dna adducts were observed in liver and two were observed in lung dna hydrolysates from rats given injections of [ 3h ] bp . | NA | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
6,
17
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
71,
74
]
} |
enzymically hydrolyzed dna analyzed by hplc revealed three adducts , two of which cochromatographed with the two dna adducts isolated from human bronchus dna adduct which had the same retention time as did the major liver and lung dna adduct from rats given i.p . injections of [ 3h ] -6-nbp . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
23,
26
]
} | {
"id": "C0242958",
"name": "dna adduct",
"pos": [
231,
241
]
} |
in each case the major adduct from dna hydrolysates of rat liver and lung , human bronchus , and s. typhimurium , all treated with [ 3h ] -6-nbp , cochromatographed with the major dna adduct isolated from liver and lung dna of rats given [ 3h ] bp . | NA | {
"id": "C0242958",
"name": "dna adduct",
"pos": [
180,
190
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
220,
223
]
} |
the results show that : pseudouridine excretion by chick embryo fibroblasts transformed by rous sarcoma virus is several times higher than that of normal cells ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
64,
75
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
154,
159
]
} |
none of the growth factors tested either alone or in combination , including platelet-derived growth factor , epidermal growth factor , alpha-type transforming growth factor , and beta-type transforming growth factor , were capable of inducing melanoma colony formation to the 12-fold stimulation observed with the plate... | NA | {
"id": "C0040688",
"name": "alpha",
"pos": [
136,
141
]
} | {
"id": "C0040691",
"name": "transforming growth factor",
"pos": [
190,
216
]
} |
after i.v . injection , blood nitrosamine concentrations declined in an apparently biexponential manner with a terminal half-life of 10 min for ndma and 12 min for [ 2h6 ] ndma . | NA | {
"id": "C0028197",
"name": "nitrosamine",
"pos": [
30,
41
]
} | {
"id": "C0012431",
"name": "ndma",
"pos": [
172,
176
]
} |
besides , a highly significant correlation was found in these tumors between various c-19 steroids ( dehydroepiandrosterone and androstane-3 alpha , 17 beta-diol , r = 0.97 , p less than 0.01 ) , suggesting a possible conversion of c-19 precursors into potent androgens in the tumors . | NA | {
"id": "C0038317",
"name": "steroids",
"pos": [
90,
98
]
} | {
"id": "C0002854",
"name": "androstane",
"pos": [
128,
138
]
} |
for neither monoclonal antibody was there any association between antibody reactivity and the morphological subtype of lymphoma examined or the type of cell surface immunoglobulin expressed . | NA | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
12,
22
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
66,
74
]
} |
the transforming activity is characterized by stimulation of anchorage-independent growth of normal rat kidney fibroblasts and competition with 125i-epidermal growth factor for binding to normal rat kidney cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
111,
122
]
} | {
"id": "C0007634",
"name": "normal",
"pos": [
188,
194
]
} |
using monoclonal antibodies to mr 70,000 glycoprotein epitopes characteristic of ecotropic , xenotropic , or dualtropic viruses , antigens marking each virus form were found on thymocytes of allogeneic 4-wk and 4-mo chimeras as well as on the cells of akr mice and of akr mice reconstituted with syngeneic marrow . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
54,
62
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
130,
138
]
} |
at either 6 or 24 h after injection with cis-ddp , the rate of elution of the dna was substantially increased by pk , indicating a large contribution of dna-protein cross-links . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
78,
81
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
155,
156
]
} |
dehydroascorbic acid is the principal form for the cellular uptake by blood cells of vitamin c . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
0,
20
]
} | {
"id": "C0003968",
"name": "vitamin c",
"pos": [
85,
94
]
} |
since previous studies from this laboratory had shown a higher content of ascorbic acid and dehydroascorbic acid ( dha ) in chronic lymphocytic leukemia ( cll ) lymphocytes when compared to their normal counterparts , dha uptake was characterized using these cells . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
74,
87
]
} | {
"id": "C0011177",
"name": "dha",
"pos": [
218,
221
]
} |
when analyzed in light of the 3-fold greater cellular dha and ascorbic acid content in b-cell cll as compared to normal lymphocytes , these kinetic parameters support the occurrence of a concentration-dependent transport system for dha . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
62,
75
]
} | {
"id": "C0011177",
"name": "dha",
"pos": [
232,
235
]
} |
we have found that tpa and teleocidin markedly enhance the transformation of c3h 10t1/2 mouse fibroblasts when these cells are transfected with the cloned h-ras human bladder cancer oncogene . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
94,
105
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
117,
122
]
} |
while the fluid is usually a benign effusion , the clinical picture and ct pattern may suggest a subdural abscess ( empyema ) necessitating further subdural punctures . | NA | {
"id": "C0038539",
"name": "subdural abscess",
"pos": [
97,
113
]
} | {
"id": "C0014009",
"name": "empyema",
"pos": [
116,
123
]
} |
the same dichotomy between the levels of the two decarboxylases was observed for meningiomas , in which odc levels were higher in atypical forms ( with karyokinesis ) then in typical forms ( without karyokinesis ) . | NA | {
"id": "C0007054",
"name": "decarboxylases",
"pos": [
49,
63
]
} | {
"id": "C0029282",
"name": "odc",
"pos": [
104,
107
]
} |
time dependence of f uptake in demineralized enamel from 1,000-ppm fluoride naf and na2fpo3 solutions . | NA | {
"id": "C0016327",
"name": "f",
"pos": [
17,
18
]
} | {
"id": "C0037508",
"name": "naf",
"pos": [
76,
79
]
} |
this effect may be due to the stimulation to division of haematopoietic progenitor cells , offsetting the lysis of other non-adherent cells . | NA | {
"id": "C0018956",
"name": "haematopoietic progenitor cells",
"pos": [
57,
88
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
116,
119
]
} |
the cells mostly found in centriacinous pericellular collagenization and in fibrous tissue were fibroblasts , myofibroblasts were less frequent whereas ito 's cells were much reduced or missing . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
4,
9
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
113,
124
]
} |
it was concluded that carcinogenicity of hexestrol was not based on its conversion to diethylstilbestrol . | NA | {
"id": "C0019467",
"name": "hexestrol",
"pos": [
41,
50
]
} | {
"id": "C0012203",
"name": "diethylstilbestrol",
"pos": [
86,
104
]
} |
the interaction of menadione with reduced glutathione ( gsh ) led to a removal of menadione and formation of menadione-gsh conjugate and glutathione disulfide ( gssg ) . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
56,
59
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
161,
165
]
} |
the changes in thiol level were essentially biphasic with an initial rapid decrease in gsh and appearance of gssg ( less than 1 min ) followed by secondary less pronounced changes . | NA | {
"id": "C0017817",
"name": "gsh",
"pos": [
87,
90
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
109,
113
]
} |
the modification of specific amino acid residues in acid-soluble nuclear proteins ( h ) and non-histone nuclear proteins ( nh ) was studied after exposing the cells to various doses of alkylating agents overnight . | NA | {
"id": "C0019652",
"name": "histone",
"pos": [
96,
103
]
} | {
"id": "C0028589",
"name": "nuclear proteins",
"pos": [
104,
120
]
} |
a superfamily of proteins was defined which includes the fabps , the cellular retinol and retinoic acid binding proteins , the p2 protein of peripheral nerve myelin , and a polypeptide known as 422 whose synthesis is induced during differentiation of 3t3-l1 cells to adipocytes . | NA | {
"id": "C0060095",
"name": "fabps",
"pos": [
57,
62
]
} | {
"id": "C0067032",
"name": "p2 protein",
"pos": [
127,
137
]
} |
the protein transferred several different neutral glycosphingolipids and ganglioside gm1 equally well , but failed to accelerate phosphatidylcholine or sphingomyelin intervesicular movement . | NA | {
"id": "C0600570",
"name": "neutral glycosphingolipids",
"pos": [
42,
68
]
} | {
"id": "C0037906",
"name": "sphingomyelin",
"pos": [
152,
165
]
} |
these experiments provide compelling evidence for a broad role of the fabps in the transport , utilization and cellular economy of free fatty acids in the liver and small intestine , and also in protecting several aspects of cellular function against the modulatory effects of fatty acids , fatty acyl-coa esters , and o... | NA | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
131,
147
]
} | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
277,
288
]
} |
inhibition of colony formation by the phorbol ester tumor promoter 12-o-tetradecanoylphorbol 13-acetate ( tpa ) over a wide range of concentrations ( 10 ( -4 ) -10 ( 2 ) ng/ml ) was examined in two normal human diploid fibroblast strains and eight cell lines derived from various human tumors . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
38,
51
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
67,
103
]
} |
it did not affect the concentrations nor the spectral properties of cytochromes p-450 in hepatic and pulmonary microsomes , whereas it stimulated , especially in aroclor-pre-treated animals , cytosolic enzyme activities involved in nadp reduction ( glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase ... | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
327,
338
]
} | {
"id": "C0061516",
"name": "gssg",
"pos": [
351,
355
]
} |
lipid peroxidation aldehydes of the 4-hydroxy-alpha , beta-unsaturated type , as well as the tobacco-smoke related alpha , beta-unsaturated aldehyde , acrolein , were highly cytotoxic and decreased the intracellular thiol content in cultured human bronchial fibroblasts after treatment with micromolar concentrations . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
19,
27
]
} | {
"id": "C0001204",
"name": "acrolein",
"pos": [
151,
159
]
} |
the induction of microsomal ndma demethylase activity by isopropanol , ethanol , acetone , and fasting was closely related to the increase of dna methylation by ndma in an incubation system in vitro . | NA | {
"id": "C0022237",
"name": "isopropanol",
"pos": [
57,
68
]
} | {
"id": "C0001962",
"name": "ethanol",
"pos": [
71,
78
]
} |
the latter is a fibrous calcium silicate which is increasingly being used to replace asbestos in various industrial applications . | NA | {
"id": "C0086983",
"name": "silicate",
"pos": [
32,
40
]
} | {
"id": "C0003947",
"name": "asbestos",
"pos": [
85,
93
]
} |
in the present study , mt activity in normal fibroblasts was decreased to between 40 and 20 % of the constitutive level by 15 or 24 h exposure of the cells to exogenous o6-methylguanine ( o6-meg ) . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
45,
56
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
150,
155
]
} |
urinary free dopamine and dihydroxyphenylacetic acid , but not norepinephrine or normetanephrine , in spontaneously hypertensive rats significantly increased between the ages of 7 and 11 weeks , reflecting the dopamine changes in tissue and suggesting a selective increase of the rate of dopamine synthesis and release . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
63,
77
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
81,
96
]
} |
this activity appeared within 1 minute of exposure to angiotensin ii , and was blocked by saralasin , an angiotensin ii antagonist . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
90,
99
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
105,
119
]
} |
electrograms obtained during mapping were analyzed to determine the prevalence of local conduction failure during vt ( defined as a portion of the local electrogram that did not repeat with every tachycardia cycle ) . | NA | {
"id": "C0042514",
"name": "vt",
"pos": [
114,
116
]
} | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
196,
207
]
} |
it can be safely used in patients with unstable angina pectoris , multivessel coronary disease ( in selected instances ) , multiple stenoses in single vessels , stenoses in coronary artery bypass grafts , and recent total coronary occlusion . | NA | {
"id": "C0010068",
"name": "coronary disease",
"pos": [
78,
94
]
} | {
"id": "C0151814",
"name": "coronary occlusion",
"pos": [
222,
240
]
} |
att-20 mouse pituitary tumor cells , which can be stimulated to synthesize and secrete pro-opiomelanocortin peptides , can biosynthetically label beta-lipotropin ( beta-lph ) with [ 35s ] methionine . | NA | {
"id": "C0033195",
"name": "pro-opiomelanocortin",
"pos": [
87,
107
]
} | {
"id": "C0023832",
"name": "beta-lipotropin",
"pos": [
146,
161
]
} |
we measured free thyroxin ( ft4 ) and free triiodothyronine ( ft3 ) in serum of patients taking the anti-epileptic drugs phenytoin and carbamazepine , both by equilibrium dialysis procedures and analog-type radioimmunoassays . | NA | {
"id": "C3537002",
"name": "anti-epileptic drugs",
"pos": [
100,
120
]
} | {
"id": "C0031507",
"name": "phenytoin",
"pos": [
121,
130
]
} |
by the use of a multiple discontinuous density gradient , very low density lipoproteins , low density lipoproteins and high density lipoproteins are sharply separated , without contamination of other lipoproteins or albumin . | NA | {
"id": "C0023825",
"name": "very low density lipoproteins",
"pos": [
58,
87
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
200,
212
]
} |
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