text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the possible role in these disorders of phosphatidylcholine and linoleic acid - both present in lecithin - is discussed , with relationship to these findings . | NA | {
"id": "C1959616",
"name": "phosphatidylcholine",
"pos": [
40,
59
]
} | {
"id": "C0031617",
"name": "lecithin",
"pos": [
96,
104
]
} |
the lupus anticoagulant , an immunoglobulin of the igg or igm class , is one of a group of antiphospholipid antibodies . | NA | {
"id": "C0085240",
"name": "lupus anticoagulant",
"pos": [
4,
23
]
} | {
"id": "C0162595",
"name": "antiphospholipid antibodies",
"pos": [
91,
118
]
} |
in 36 patients representing different clinical stages of multiple sclerosis ( ms ) ( 9 patients with acute exacerbations ; 21 patients in remission ; 5 patients with chronic progressive ms ) determinations of t lymphocyte populations using monoclonal antibodies against surface antigens ( okt3 ( pan t cells ) , okt4 ( h... | NA | {
"id": "C0026769",
"name": "multiple sclerosis",
"pos": [
57,
75
]
} | {
"id": "C0393665",
"name": "chronic progressive ms",
"pos": [
166,
188
]
} |
this study suggests that patients who develop cysts lined by apocrine epithelium may be at a greater risk of subsequent breast cancer than those with flattened epithelial cysts . | NA | {
"id": "C0010709",
"name": "cysts",
"pos": [
46,
51
]
} | {
"id": "C0014511",
"name": "epithelial cysts",
"pos": [
160,
176
]
} |
a decrease in prothrombin activity from 30.5 to 20.2 % was observed , associated with a decrease in vitamin k coagulation factors , after a mean of 4 days following commencement of amiodarone . | NA | {
"id": "C0033706",
"name": "prothrombin",
"pos": [
14,
25
]
} | {
"id": "C0005789",
"name": "coagulation factors",
"pos": [
110,
129
]
} |
the peak plasma concentrations in the patients with pyelonephritis ( 3.80 micrograms/ml ) and interstitial nephritis ( 3.74 micrograms/ml ) but not in those with glomerulonephritis ( 3.17 micrograms/ml ) differed from that in healthy volunteers ( 3.24 micrograms/ml ) . | NA | {
"id": "C0034186",
"name": "pyelonephritis",
"pos": [
52,
66
]
} | {
"id": "C0027707",
"name": "interstitial nephritis",
"pos": [
94,
116
]
} |
the effect of a single therapeutic dose of nifedipine ( 20 mg p.o . ) has been evaluated on basal and submaximal pentagastrin-stimulated gastric secretion and meal-stimulated gastrin release in healthy man . | NA | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
113,
125
]
} | {
"id": "C0017151",
"name": "gastrin",
"pos": [
175,
182
]
} |
the kinetics of chloroquine and its major metabolite desethylchloroquine were studied in patients with rheumatoid disease after single oral doses of chloroquine phosphate corresponding to 150 and 300 mg chloroquine base . | NA | {
"id": "C0055447",
"name": "chloroquine phosphate",
"pos": [
149,
170
]
} | {
"id": "C0008269",
"name": "chloroquine",
"pos": [
203,
214
]
} |
by comparing an ia+ p815 tumor line with its ia- clone as allogeneic stimulator cells , it was found that the ctlp activation was also independent of ia alloantigen on the stimulator cells . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
58,
68
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
183,
188
]
} |
three benzodiazepine ( bz ) receptor ligands of the beta-carboline group , namely the bz receptor agonist zk 93 423 , the partial agonist zk 91 296 , and the antagonist zk 93 426 , were studied in epilepsy-prone mongolian gerbils with different seizure types . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
197,
205
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
245,
252
]
} |
the non-hydrolyzable gtp analog , gpp ( nh ) p ( 10 ( -9 ) - 10 ( -4 ) m ) decreased the affinity of angiotensin ii receptors for the agonist by up to 50 % , but did not affect antagonist binding to the receptor . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
21,
24
]
} | {
"id": "C0018366",
"name": "gpp ( nh ) p",
"pos": [
34,
46
]
} |
the dopaminergic inhibition of the hydrosmotic action of avp may be at least in part responsible for the diuretic action of dopamine . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
4,
16
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
124,
132
]
} |
hgf cells were plated onto collagen-coated petri dishes under various conditions and the percentage of cells attaching to the collagen was determined . | NA | {
"id": "C0016030",
"name": "hgf",
"pos": [
0,
3
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
122,
125
]
} |
furthermore , two 40-45 kd polypeptides sharing common determinants with soluble antigens were found exclusively in ethanolic extracts but not in ciliary membranes : the cross-reactivity of these light polypeptides with ethanol-extracted antigens could be demonstrated only after beta-mercaptoethanol treatment . | NA | {
"id": "C0003316",
"name": "determinants",
"pos": [
55,
67
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
238,
246
]
} |
furthermore , two 40-45 kd polypeptides sharing common determinants with soluble antigens were found exclusively in ethanolic extracts but not in ciliary membranes : the cross-reactivity of these light polypeptides with ethanol-extracted antigens could be demonstrated only after beta-mercaptoethanol treatment . | NA | {
"id": "C0001962",
"name": "ethanol",
"pos": [
116,
123
]
} | {
"id": "C0025402",
"name": "mercaptoethanol",
"pos": [
285,
300
]
} |
bromocriptine treatment did not alter the distribution of microtubules and actin filaments in fibroblasts , whereas colchicine changed the distribution of microtubules in both prolactinoma cells and fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
189,
194
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
199,
210
]
} |
treatment on day 1 of culture prevented later lentoid formation and severely reduced the expression of all crystallins with the exception of the 34k beta-crystallin polypeptide . | NA | {
"id": "C0010422",
"name": "crystallins",
"pos": [
107,
118
]
} | {
"id": "C0005203",
"name": "beta-crystallin",
"pos": [
149,
164
]
} |
actin was the most abundant soluble cell component , and a proportion of the cells acquired a fibroblast-like morphology . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
77,
82
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
94,
104
]
} |
these points considered , alpha-crystallin is the major protein in the neonatal lens ( approximately 42 % , including hm-alpha ) , followed by the beta-crystallin ( approximately 36 % at most and probably less ) , the gamma-crystallins ( approximately 11 % ) and beta s-crystallin ( approximately 9 % ) . | NA | {
"id": "C0002257",
"name": "alpha-crystallin",
"pos": [
26,
42
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
270,
280
]
} |
these points considered , alpha-crystallin is the major protein in the neonatal lens ( approximately 42 % , including hm-alpha ) , followed by the beta-crystallin ( approximately 36 % at most and probably less ) , the gamma-crystallins ( approximately 11 % ) and beta s-crystallin ( approximately 9 % ) . | NA | {
"id": "C0005203",
"name": "beta-crystallin",
"pos": [
147,
162
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
270,
280
]
} |
these points considered , alpha-crystallin is the major protein in the neonatal lens ( approximately 42 % , including hm-alpha ) , followed by the beta-crystallin ( approximately 36 % at most and probably less ) , the gamma-crystallins ( approximately 11 % ) and beta s-crystallin ( approximately 9 % ) . | NA | {
"id": "C0017030",
"name": "gamma-crystallins",
"pos": [
218,
235
]
} | {
"id": "C0010422",
"name": "crystallin",
"pos": [
270,
280
]
} |
a hplc method for determination of ascorbic acid and dehydroascorbic acid in plasma and aqueous and vitreous humors of rabbits is described . | NA | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
35,
48
]
} | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
53,
73
]
} |
previously , we showed that the clotting factor thrombin binds to bovine corneal endothelial cells forming a covalent complex with a protein released by these cells into the culture media . | NA | {
"id": "C0005789",
"name": "clotting factor",
"pos": [
32,
47
]
} | {
"id": "C0040018",
"name": "thrombin",
"pos": [
48,
56
]
} |
based upon the amino acid sequence of bovine lens mip26k obtained from cdna cloning ( gorin , yancey , cline , revel and horwitz , 1984 ) , two octapeptides ( amino acid nos 252-259 , 240-247 ) near the c-terminus have been synthesized . | NA | {
"id": "C0301714",
"name": "based",
"pos": [
0,
5
]
} | {
"id": "C0002520",
"name": "amino",
"pos": [
159,
164
]
} |
either dna-synthesizing bfu-e have a higher buoyant density than non-dna-synthesizing bfu-e , or else cells of lower buoyant density normally inhibit dna synthesis in bfu-e . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
7,
10
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
152,
153
]
} |
the present study demonstrated that systemic administration of the adenosine analog , l-phenylisopropyladenosine ( l-pia ) , substantially prolonged the postictal depression and decreased the frequency of spiking that follows amygdala-kindled seizures in rats . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
67,
76
]
} | {
"id": "C0031484",
"name": "l-phenylisopropyladenosine",
"pos": [
86,
112
]
} |
male sprague-dawley rats were treated during 20 h with subcutaneously implanted tablets ( controlled release systems ) containing either adrenaline ( a ) , noradrenaline ( na ) , isoprenaline ( iso ) or just placebos . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
137,
147
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
156,
169
]
} |
of 360 mab obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cell lines , 30 mab were selected which reacted more strongly with tumor cells than with ( noncancerous ) fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
64,
69
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
248,
259
]
} |
in mixed culture of chinese hamster fibroblasts , clone 431 , and transformed murine l fibroblasts , clone b-82 , isoproterenol was found to protect only 431 cells against ionizing radiation . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
36,
47
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
158,
163
]
} |
in eeg , dose-response curves for six amino acids ( l-glutamine , l-alanine , l-arginine , l-methionine , l-serine and glycine ) showed two different functions within the range tested ( 10 ( -5 ) to 10 ( -2 ) m ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0001898",
"name": "l-alanine",
"pos": [
66,
75
]
} |
in eeg , dose-response curves for six amino acids ( l-glutamine , l-alanine , l-arginine , l-methionine , l-serine and glycine ) showed two different functions within the range tested ( 10 ( -5 ) to 10 ( -2 ) m ) . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
38,
49
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
119,
126
]
} |
the time course of concentrations in the plasma , aqueous and vitreous humor , ciliary body , and retina showed kinetics described by the exponential equation y = aebx with a half-life of 2.47 , 4.56 , 3.59 , and 3.22 hr , respectively ; | NA | {
"id": "C0022702",
"name": "kinetics",
"pos": [
112,
120
]
} | {
"id": "C0018517",
"name": "half-life",
"pos": [
175,
184
]
} |
due to the ubiquitous nature of airborne endotoxin , an understanding of pulmonary alterations which follow inhalation of environmentally realistic concentrations of purified bacteria derived lipopolysaccharide ( lps ) is important . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
41,
50
]
} | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
192,
210
]
} |
using lps derived from enterobacter agglomerans , a bacterium found in cotton and cotton mill dust , aqueous aerosols ( effective lps concentration 4 micrograms/m3 ) were generated and used to expose either normal hamsters ( n = 6 ) or those rendered endotoxin tolerant by pre-ip injection of 0.1 ld50 lps . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
251,
260
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
302,
305
]
} |
energy dispersive x-ray and line profile analysis showed that the major elements in the heavily calcified portions of the plaques were calcium and phosphorus . | NA | {
"id": "C0013879",
"name": "elements",
"pos": [
72,
80
]
} | {
"id": "C0031705",
"name": "phosphorus",
"pos": [
147,
157
]
} |
lipid x , as well as lipopolysaccharide and lipid a , enhanced o2- generation in mouse peritoneal macrophages and a macrophage-like cell line , j774.1 , and further induced the tumor-cytotoxic activity of peritoneal macrophages . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
21,
39
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
44,
51
]
} |
a small population of ompa , a major protein from the outer membrane of escherichia coli , was found covalently associated with either lipopolysaccharide or o-antigen polysaccharide . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
135,
153
]
} | {
"id": "C0069180",
"name": "o-antigen",
"pos": [
157,
166
]
} |
thirteen cases of malignant lymphoma , exclusive of mycosis fungoides , with initial involvement of the skin , were selected from 391 consecutive patients with non-hodgkin 's lymphoma . | NA | {
"id": "C0024299",
"name": "malignant lymphoma",
"pos": [
18,
36
]
} | {
"id": "C0024305",
"name": "non-hodgkin 's lymphoma",
"pos": [
160,
183
]
} |
when the spontaneous frequency of these oscillations exceeds the rate of external simulation , they appear between stimulated contractions and impart a variable ca2+-dependent component of diastolic tonus and a propensity for extrasystoles and arrhythmias to occur ; | NA | {
"id": "C0340464",
"name": "extrasystoles",
"pos": [
226,
239
]
} | {
"id": "C0003811",
"name": "arrhythmias",
"pos": [
244,
255
]
} |
we have proposed that the naturally occurring alkaloid ryanodine reduces the release of calcium from the sarcoplasmic reticulum ( sr ) in cardiac muscle cells . | NA | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
46,
54
]
} | {
"id": "C0035983",
"name": "ryanodine",
"pos": [
55,
64
]
} |
the foetal consequences of transplacental transmission of maternal cells and allogeneic cells injected into the maternal circulation were studied . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C3485979",
"name": "allogeneic cells",
"pos": [
77,
93
]
} |
stabile hybridoma cells , colonies of hybridoma cells 14 days after fusion of immune spleen and myeloma cells , myeloma cells and fibroblasts cultured in 96-well microculture plates were frozen by the method of two-step freezing . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
18,
23
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
130,
141
]
} |
the intermediate lobe of the rat pituitary gland is a homogeneous population of cells which synthesize and secrete various peptides related to acth and lipotropin derived from a common precursor , proopiomelanocortin . | NA | {
"id": "C0023832",
"name": "lipotropin",
"pos": [
152,
162
]
} | {
"id": "C0033195",
"name": "proopiomelanocortin",
"pos": [
197,
216
]
} |
data presented for 11 bulk commercial samples show that the most abundant amino acids are glycine , glutamic acid , aspartic acid , serine and alanine , but that their relative proportions vary considerably . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
74,
85
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
90,
97
]
} |
data presented for 11 bulk commercial samples show that the most abundant amino acids are glycine , glutamic acid , aspartic acid , serine and alanine , but that their relative proportions vary considerably . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
74,
85
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
143,
150
]
} |
their amino acid compositions are characterized by the presence of very large but variable proportions of hydroxyproline and substantial proportions of serine , proline and valine . | NA | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
106,
120
]
} | {
"id": "C0033382",
"name": "proline",
"pos": [
161,
168
]
} |
cultured chick embryo fibroblast , and rat spleen , cells rapidly and very efficiently import their own or each others cytosolic dna complexes into their respective cytosol fractions : the material recovered from the cytosol of recipient cells is characteristic of the presented material . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
22,
32
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
238,
243
]
} |
that ( ca2+-mg2+ ) -atpase and ca2+-atpase are probably expressions of the same ca2+-pump atpase in the plasma membrane of the cell . | NA | {
"id": "C0001473",
"name": "atpase",
"pos": [
20,
26
]
} | {
"id": "C0001476",
"name": "ca2",
"pos": [
80,
83
]
} |
a comparison of the lipid classes and essential fatty acid content of rat plasma lipoproteins and ovary . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
20,
25
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
81,
93
]
} |
radioactive riboflavin and homologs of riboflavin possessing an ethyl group in positions 7- or 8- , or both were used to investigate the covalent bonding of the flavins . | NA | {
"id": "C0035527",
"name": "riboflavin",
"pos": [
12,
22
]
} | {
"id": "C0016213",
"name": "flavins",
"pos": [
161,
168
]
} |
bovine granulosa cell membranes from small ( sfm ) and large ( lfm ) antral follicles were incubated with [ 3h ] heparin , a commercial radioactively labeled glycosaminoglycan ( gag ) . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
113,
120
]
} | {
"id": "C0017973",
"name": "glycosaminoglycan",
"pos": [
158,
175
]
} |
addition of unlabeled heparin ( 0.1-100 micrograms/ml ) displaced [ 3h ] heparin bound to sfm and lfm in a dose-dependent manner , as did dextran sulfate , a non-gag sulfated branched polysaccharide . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
22,
29
]
} | {
"id": "C0017973",
"name": "gag",
"pos": [
162,
165
]
} |
these experiments demonstrated that the gag heparin specifically bound to bovine granulosa cell membranes , and that significant differences existed between the binding characteristics of sfm and lfm . | NA | {
"id": "C0017973",
"name": "gag",
"pos": [
40,
43
]
} | {
"id": "C0019134",
"name": "heparin",
"pos": [
44,
51
]
} |
these data also indicate that there is a major interaction of insulin and insulin-like hormones with normal human platelets and support previous demonstrations of major insulin effects on platelet physiology in both normal and diabetic states . | NA | {
"id": "C0795635",
"name": "insulin",
"pos": [
62,
69
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
169,
176
]
} |
techniques used to restrict gut-derived lps availability included chronic daily gavage with neomycin and cefazolin for gut sterilization and with cholestyramine or lactulose to reduce endotoxin within the gut . | NA | {
"id": "C0023810",
"name": "lps",
"pos": [
40,
43
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
184,
193
]
} |
in addition , induction of endotoxin tolerance was produced by progressively higher doses of lps intraperitoneally ( i.p . ) , and polymyxin b was administered subcutaneously ( s.c. ) daily to neutralize the lipid a portion of circulating lps . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
27,
36
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
239,
242
]
} |
in addition , induction of endotoxin tolerance was produced by progressively higher doses of lps intraperitoneally ( i.p . ) , and polymyxin b was administered subcutaneously ( s.c. ) daily to neutralize the lipid a portion of circulating lps . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
208,
215
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
239,
242
]
} |
despite perfect blood glucose control and normal glucose flux rates , the concentration and rates of appearance and disappearance of alanine were significantly elevated in the diabetic animals before , during and after an exogenous glucose load . | NA | {
"id": "C0005802",
"name": "blood glucose",
"pos": [
16,
29
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
232,
239
]
} |
mechanism of the stimulation of insulin release in vitro by hb 699 , a benzoic acid derivative similar to the non-sulphonylurea moiety of glibenclamide . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
114,
127
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
138,
151
]
} |
a sulphonylurea group is thus not a prerequisite to trigger the sequence of events that is also thought to underlie the releasing effects of tolbutamide and glibenclamide . | NA | {
"id": "C0038766",
"name": "sulphonylurea",
"pos": [
2,
15
]
} | {
"id": "C0017628",
"name": "glibenclamide",
"pos": [
157,
170
]
} |
shock was characterized by reductions in cardiac output and blood pressure , and increased plasma concentrations of epinephrine , norepinephrine , thromboxane b2 , 6-keto pgf1 alpha , and lactate . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
116,
127
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
130,
144
]
} |
there were 20 episodes of abdominal pain ( peritonitis : 9 , pancreatitis : 4 , acute cholecystitis : 2 , duodenal ulcer : 3 , intestinal infarction : 1 , unexplained pain without diagnosis at laparotomy : 1 ) and 11 of gastrointestinal hemorrhage ( melaena or hematemesis : 4 ; | NA | {
"id": "C0017181",
"name": "gastrointestinal hemorrhage",
"pos": [
220,
247
]
} | {
"id": "C0025222",
"name": "melaena",
"pos": [
250,
257
]
} |
there were 20 episodes of abdominal pain ( peritonitis : 9 , pancreatitis : 4 , acute cholecystitis : 2 , duodenal ulcer : 3 , intestinal infarction : 1 , unexplained pain without diagnosis at laparotomy : 1 ) and 11 of gastrointestinal hemorrhage ( melaena or hematemesis : 4 ; | NA | {
"id": "C0017181",
"name": "gastrointestinal hemorrhage",
"pos": [
220,
247
]
} | {
"id": "C0018926",
"name": "hematemesis",
"pos": [
261,
272
]
} |
in order to elucidate the vasopressor mechanism of ang ii in the snake , and to test the presence of common adrenergic-ang receptors , the contractile response of isolated snake dorsal aorta to [ val5 ] ang ii and norepinephrine ( ne ) was studied using the cobra , naja naja and the rat snake , ptyas korros . | NA | {
"id": "C0003018",
"name": "ang",
"pos": [
51,
54
]
} | {
"id": "C0003009",
"name": "ang",
"pos": [
203,
206
]
} |
thallium ions ( 2.5 x 10 ( -3 ) and 5 x 10 ( -3 ) mol/l ) in sodium- and potassium- free magnesium ringer solution caused a large increase in effluxes of all the cations examined ( k+ , rb+ and na+ ) both in presence and absence of gramicidin . | NA | {
"id": "C0022023",
"name": "ions",
"pos": [
9,
13
]
} | {
"id": "C0007447",
"name": "cations",
"pos": [
162,
169
]
} |
the homologous patches in the sequences of all four enzymes suggest that those might correspond to contact points for the common substrates , e.g. , for the adenosine residue ( s ) and s-adenosylmethionine ( sam ) . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
157,
166
]
} | {
"id": "C0036002",
"name": "sam",
"pos": [
208,
211
]
} |
myocardial responsiveness to catecholamines was evaluated by measuring isoproterenol-stimulated adenylate cyclase activities in myocardial particulate fractions from fischer 344 rats of 3 , 12 , and 24 months of age . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
29,
43
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
71,
84
]
} |
fibrovascular proliferation from around the optic nerve head made a major contribution to the formation of membranes in the experiments with homologous fibroblasts but not those using the autologous cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
152,
163
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
199,
204
]
} |
the animals were treated with bromhexine ( bisolvon ) , ambroxol ( mucosolvan ) , or placebo from their 20th week of life for 10-17 weeks . | NA | {
"id": "C0006220",
"name": "bromhexine",
"pos": [
30,
40
]
} | {
"id": "C0002421",
"name": "ambroxol",
"pos": [
56,
64
]
} |
in the first phase , which was morphologically characterized by the destruction of the epithelium and keratocytes and by the infiltration of the cornea with polymorphonuclear leukocytes , an increase in the activity of lysosomal phosphatases and glycosidases ( beta-d-glucuronidase , acid beta-d-galactosidase , beta-d-n... | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
246,
258
]
} | {
"id": "C0017776",
"name": "glucuronidase",
"pos": [
268,
281
]
} |
in the first phase , which was morphologically characterized by the destruction of the epithelium and keratocytes and by the infiltration of the cornea with polymorphonuclear leukocytes , an increase in the activity of lysosomal phosphatases and glycosidases ( beta-d-glucuronidase , acid beta-d-galactosidase , beta-d-n... | NA | {
"id": "C0017976",
"name": "glycosidases",
"pos": [
246,
258
]
} | {
"id": "C0016955",
"name": "galactosidase",
"pos": [
296,
309
]
} |
discriminant function analysis revealed that the ratio of pepsinogen i to ii , in combination with the absolute level of pepsinogen ii , had a sensitivity of 80 % , a specificity of 73 % , and a positive predictive value of 87 % for atrophic gastritis in this population . | NA | {
"id": "C0077923",
"name": "pepsinogen i",
"pos": [
58,
70
]
} | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
121,
131
]
} |
from a prognostic point of view , the risk factors indicative of an unfavorable outcome of seizures were found as follows : a ) the presence of generalized tonic-clonic convulsions ( gtcs ) prior to the occurrence of minor seizures and persisting gtcs following the subsidence of minor seizures , b ) scanty epileptic ee... | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
308,
317
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
423,
430
]
} |
eight-day-old mice were given by gavage glutamate and aspartate mixtures providing each amino acid at 125 , 250 or 500 mg/kg body weight ( 250 , 500 and 1000 mg total dicarboxylic amino acids/kg ) and the degree and extent of neuronal necrosis were determined . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
88,
98
]
} | {
"id": "C0002524",
"name": "dicarboxylic amino acids",
"pos": [
167,
191
]
} |
the standard deviation ( s.d . ) of breath alcohol determinations increased with increase in the concentration of alcohol in the sample , being 0.036 mg/ml at a mean blood-ethanol concentration of 0.53 mg/ml . | NA | {
"id": "C0001962",
"name": "alcohol",
"pos": [
43,
50
]
} | {
"id": "C0684262",
"name": "blood-ethanol concentration",
"pos": [
166,
193
]
} |
the present results indicate that the greenish discoloration of decomposed cadavers is due to formation of a mixture of shb , choleglobin and possibly other denatured hemoglobin derivatives . | NA | {
"id": "C0038731",
"name": "shb",
"pos": [
120,
123
]
} | {
"id": "C0019046",
"name": "hemoglobin",
"pos": [
167,
177
]
} |
this metabolic state was accompanied by hyperinsulinism both in vivo and in vitro , suggesting that a state of insulin resistance has developed . | NA | {
"id": "C0020459",
"name": "hyperinsulinism",
"pos": [
40,
55
]
} | {
"id": "C0021655",
"name": "insulin resistance",
"pos": [
111,
129
]
} |
we performed the euglycemic insulin clamp technique on four patients with cushing 's syndrome , five obese patients and five normal volunteers , in order to determine the role of impairments in insulin responsiveness and insulin clearance in hypercorticism and obesity . | NA | {
"id": "C0010481",
"name": "cushing 's syndrome",
"pos": [
74,
93
]
} | {
"id": "C0001622",
"name": "hypercorticism",
"pos": [
242,
256
]
} |
we report a patient with a long history of pan-hypopituitarism treated with pituitary snuff who developed superior mediastinal fibrosis involving the visceral pericardium , retroperitoneal fibrosis , and a peculiar widespread nodular fibrosis of the lungs . | NA | {
"id": "C0016059",
"name": "fibrosis",
"pos": [
127,
135
]
} | {
"id": "C0035357",
"name": "retroperitoneal fibrosis",
"pos": [
173,
197
]
} |
progesterone was inhibitory at low concentrations but stimulatory at higher ones , while 17-hydroxyprogesterone was neither inhibitory nor stimulatory . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
0,
12
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
89,
111
]
} |
[ clinical aspects and pathophysiology of carcinoid and carcinoid syndrome with special reference to the pharmacology of 5-hydroxytryptamine ] . | NA | {
"id": "C0007095",
"name": "carcinoid",
"pos": [
42,
51
]
} | {
"id": "C0024586",
"name": "carcinoid syndrome",
"pos": [
56,
74
]
} |
[ influence of the ventilatory rate on the tensional effects of adrenaline and noradrenaline in perfusion ] . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
64,
74
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
79,
92
]
} |
[ a new cleansing-protective paste for the prevention of pyoderma and other industrial diseases of the skin ] . | NA | {
"id": "C0034212",
"name": "pyoderma",
"pos": [
57,
65
]
} | {
"id": "C0037274",
"name": "diseases of",
"pos": [
87,
98
]
} |
[ indices of blood coagulation processes ( fibrinogen , prothrombin , factor v and factor vii ) in the evaluation of functional conditions of the liver in botkin 's disease and cirrhosis ] . | NA | {
"id": "C0023895",
"name": "the",
"pos": [
99,
102
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
177,
186
]
} |
[ on the chromatographic purity test for lobeline , cocaine , pilocarpine and papaverine hydrochlorides . 11. on the behavior of alkaloid salt solutions on aluminum oxide columns ] . | NA | {
"id": "C0023929",
"name": "lobeline",
"pos": [
41,
49
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
129,
137
]
} |
[ on the chromatographic purity test for lobeline , cocaine , pilocarpine and papaverine hydrochlorides . 11. on the behavior of alkaloid salt solutions on aluminum oxide columns ] . | NA | {
"id": "C0031923",
"name": "pilocarpine",
"pos": [
62,
73
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
129,
137
]
} |
this compound was effective against gram-negative as well as gram-positive microorganisms , yeast , and fungi.a high order of microbiological activity was demonstrated with various higher amine salts of dicarboxylic and tricarboxylic acids , e.g. , tetradecylammonium oxalate , tetradecylammonium citrate , and so forth ... | NA | {
"id": "C0040887",
"name": "tricarboxylic acids",
"pos": [
220,
239
]
} | {
"id": "C0008857",
"name": "citrate",
"pos": [
297,
304
]
} |
[ variations of the blood sugar and blood pyruvates after administration of glucose to normal gravid women ] . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
20,
31
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
76,
83
]
} |
studies of adrenal nucleic acids : the influence of acth , unilateral adrenalectomy and growth hormone upon adrenal rna and dna in the dog . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
19,
32
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
124,
127
]
} |
[ on the behavior of glutamic oxalacetic transaminase , glutamic pyruvic transaminase , sorbitol dehydrogenase and cholinesterase of the serum following heart operations ] . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
41,
53
]
} | {
"id": "C0001899",
"name": "glutamic pyruvic",
"pos": [
56,
72
]
} |
in dinitrophenol-treated tissues , in which all permeability processes are irreversibly damaged and in which sucrose and pentoses penetrate into most of the cell water , the entry rate of pentoses and sucrose is initially similar but subsequently d-xylose and l-arabinose penetrate more rapidly than their corresponding ... | NA | {
"id": "C0030894",
"name": "pentoses",
"pos": [
121,
129
]
} | {
"id": "C0043375",
"name": "xylose",
"pos": [
249,
255
]
} |
in dinitrophenol-treated tissues , in which all permeability processes are irreversibly damaged and in which sucrose and pentoses penetrate into most of the cell water , the entry rate of pentoses and sucrose is initially similar but subsequently d-xylose and l-arabinose penetrate more rapidly than their corresponding ... | NA | {
"id": "C0030894",
"name": "pentoses",
"pos": [
121,
129
]
} | {
"id": "C0003682",
"name": "l-arabinose",
"pos": [
260,
271
]
} |
[ behavior of glutamic-oxalicacetic transaminase , glutamic-pyruvic transaminase , lactic dehydrogenase and cholinesterase in maternal and umbilical blood in normal pregnancies and in pregnancies complicated by pre-eclamptic states ] . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
36,
48
]
} | {
"id": "C0001899",
"name": "glutamic-pyruvic transaminase",
"pos": [
51,
80
]
} |
adrenaline and noradrenaline also cause a block in the release of oxytocin , and it is suggested that adrenaline blocks the central release of oxytocin as well as blocking its peripheral action . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
15,
28
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
[ examination of the digestion and absorption of lipids by means of the use of labeled fats ] . | NA | {
"id": "C0023779",
"name": "lipids",
"pos": [
49,
55
]
} | {
"id": "C0015677",
"name": "fats",
"pos": [
87,
91
]
} |
[ on a case of rare congenital heart abnormality . cor triloculare biatriatum with persistence of a bivalve ductus arteriosus ; perforation of the interatrial septum ; abnormalities of the great vessels ] . | NA | {
"id": "C0018798",
"name": "of",
"pos": [
12,
14
]
} | {
"id": "C0013274",
"name": "persistence",
"pos": [
83,
94
]
} |
[ the practical conditions of use of stabilized parasitic antigens in the immunological diagnosis of helminthiases ] . | NA | {
"id": "C0030499",
"name": "conditions",
"pos": [
16,
26
]
} | {
"id": "C0018889",
"name": "helminthiases",
"pos": [
101,
114
]
} |
1961.-two sialic acids , n-acetylneuraminic acid and n,7-o-diacetylneuraminic acid , were obtained in crude mixtures from whole cells of escherichia coli and from its endotoxin by weak acid hydrolysis followed by anion exchange resin chromatography . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
10,
22
]
} | {
"id": "C0067762",
"name": "n-acetylneuraminic acid",
"pos": [
25,
48
]
} |
the two sialic acids were separated on paper chromatograms , eluted , and assays for total and ester acyl groups showed the suspected n-acetyl derivative to contain 0.11 o-acyl and 1.16 n-acetyl groups per mole sialic acid and the diacetyl derivative to have 1.10 o-acyl and 0.93 n-acetyl groups per mole . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
8,
20
]
} | {
"id": "C0067762",
"name": "sialic acid",
"pos": [
211,
222
]
} |
although there is good correlation of the occurrence of sialic acids with the e. coli capsular antigen , k ( 1 ) , specific release of sialic acid from k ( 1 ) antigen with neuraminidase does not lessen its haptenic activity as measured by inhibition of specific agglutination . | NA | {
"id": "C0037025",
"name": "sialic acids",
"pos": [
56,
68
]
} | {
"id": "C0067762",
"name": "sialic",
"pos": [
135,
141
]
} |
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