text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in alloxan-diabetes , the concentration of acetylcarnitine was increased in all four tissues examined , but the total acid-soluble carnitine concentration was increased sevenfold in the liver and twofold in kidney cortex . | NA | {
"id": "C0001040",
"name": "acetylcarnitine",
"pos": [
43,
58
]
} | {
"id": "C0007258",
"name": "carnitine",
"pos": [
131,
140
]
} |
release of growth hormone was increased by 45min incubation in 1mum-prostaglandin e ( 2 ) in the absence of theophylline , or in 10nm-prostaglandin e ( 2 ) , 0.1mum-prostaglandin a ( 1 ) or 1mum-prostaglandin b ( 1 ) in the presence of 0.5mm-theophylline . | NA | {
"id": "C0033559",
"name": "prostaglandin",
"pos": [
68,
81
]
} | {
"id": "C0033554",
"name": "prostaglandin",
"pos": [
195,
208
]
} |
over 1000 semi-synthetic penicillins were tested for inhibitory activity against the beta-lactamase of escherichia coli b11 and 18 showed a fractional inhibition similar to or higher than that of methicillin . | NA | {
"id": "C0030842",
"name": "penicillins",
"pos": [
25,
36
]
} | {
"id": "C0025643",
"name": "methicillin",
"pos": [
196,
207
]
} |
the k ( i ) was 0.004mum and k ( i ) /k ( m ) with ampicillin and p-hydroxyampicillin ( brl 2333 ) was about 0.0001 . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
51,
61
]
} | {
"id": "C0002645",
"name": "p-hydroxyampicillin",
"pos": [
66,
85
]
} |
with chloride , bromide or iodide as the predominant anion , atp synthesis linked to the oxidation of pyruvate or succinate and atp hydrolysis stimulated by 2,4-dinitrophenol are much more sensitive to triethyltin than they are when nitrate or isethionate is the predominant anion . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
5,
13
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
275,
280
]
} |
with chloride , bromide or iodide as the predominant anion , atp synthesis linked to the oxidation of pyruvate or succinate and atp hydrolysis stimulated by 2,4-dinitrophenol are much more sensitive to triethyltin than they are when nitrate or isethionate is the predominant anion . | NA | {
"id": "C0006222",
"name": "bromide",
"pos": [
16,
23
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
275,
280
]
} |
with chloride , bromide or iodide as the predominant anion , atp synthesis linked to the oxidation of pyruvate or succinate and atp hydrolysis stimulated by 2,4-dinitrophenol are much more sensitive to triethyltin than they are when nitrate or isethionate is the predominant anion . | NA | {
"id": "C0021966",
"name": "iodide",
"pos": [
27,
33
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
275,
280
]
} |
with chloride , bromide or iodide as the predominant anion , atp synthesis linked to the oxidation of pyruvate or succinate and atp hydrolysis stimulated by 2,4-dinitrophenol are much more sensitive to triethyltin than they are when nitrate or isethionate is the predominant anion . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
233,
240
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
275,
280
]
} |
when nitrate or isethionate is the predominant anion , oxygen uptake stimulated by 2,4-dinitrophenol is not inhibited by triethyltin . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
5,
12
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
47,
52
]
} |
in the presence of nitrate or isethionate anions , inhibition of atp synthesis is directly related to the binding of triethyltin to mitochondria . | NA | {
"id": "C0028125",
"name": "nitrate",
"pos": [
19,
26
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
42,
48
]
} |
increased accumulation of ( 3 h ) catecholamines formed from ( 3 h ) dopa after treatment with caffeine and aminophylline . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
34,
48
]
} | {
"id": "C0013023",
"name": "dopa",
"pos": [
69,
73
]
} |
although classical myocardial infarction was confirmed to be relatively infrequent , myocardial disorders with many of the features of ischaemic heart disease are an important cause of death in rural jamaicans . | NA | {
"id": "C0027051",
"name": "myocardial infarction",
"pos": [
19,
40
]
} | {
"id": "C0151744",
"name": "of the",
"pos": [
116,
122
]
} |
the detection of virus-neutralizing antibody and high titres of neuraminidase-inhibiting antibody for hong kong/68 virus , and the production of precipitin lines corresponding to influenza a ribonucleoprotein and haemagglutinin and neuraminidase antigens of hong kong virus in immunodiffusion tests indicated that the sw... | NA | {
"id": "C0475463",
"name": "neutralizing antibody",
"pos": [
23,
44
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
339,
347
]
} |
a few hours after medication , plasma cholinesterase was almost completely inhibited , regardless of the dose given , while erythrocyte cholinesterase was almost completely inhibited , regardless of the dose given , while erythrocyte cholinesterase was inhibited down to 40-60 % of the pretreatment level , depending on ... | NA | {
"id": "C0008429",
"name": "plasma cholinesterase",
"pos": [
31,
52
]
} | {
"id": "C0001044",
"name": "erythrocyte cholinesterase",
"pos": [
222,
248
]
} |
plasma cholinesterase was inhibited to a greater extent than erythrocyte cholinesterase but showed a more rapid recovery of activity . | NA | {
"id": "C0008429",
"name": "plasma",
"pos": [
0,
6
]
} | {
"id": "C0001044",
"name": "erythrocyte cholinesterase",
"pos": [
61,
87
]
} |
the roles of alanine as a major precursor among amino acids for hepatic gluconeogenesis and as a major end product of the degradation of amino acids in rat tissues . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
13,
20
]
} | {
"id": "C0002520",
"name": "amino acids",
"pos": [
137,
148
]
} |
[ action of insulin on the transmembranous glucose content in the isolated perfused rat heart . vii . influencing of the glucose uptake and the distribution volume as well as the glycogen content by proinsulin ] . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
12,
19
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
199,
209
]
} |
the dissociation constant of the enzyme-nadh complex is unaffected by inactivation of the enzyme with iodoacetamide , and the affinity of the enzyme for nad ( + ) and pyridine-3-aldehyde-adenine dinucleotide ( paad ( + ) ) appears to be similarly unaffected . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
33,
39
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
142,
148
]
} |
enzyme inactivated with iodoacetamide has lost the ability to form normal ternary complexes of the type enzyme-nadh-acetamide and enzyme-paad ( + ) -hydroxylamine that are characteristic of the native enzyme . | NA | {
"id": "C0026741",
"name": "complexes",
"pos": [
82,
91
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
201,
207
]
} |
the results are discussed and taken to confirm that the order of magnitude of the value of the redox state of the cytoplasmic nad couple in rat liver is controlled by the phosphorylation state of the adenine nucleotide system . | NA | {
"id": "C0027270",
"name": "nad",
"pos": [
126,
129
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
200,
218
]
} |
solutions of anionic liquid ion-exchangers in organic solvents are potentially useful for extracting steroidal glucosiduronic acids from biological fluids and for purifying mixtures of these acids by chromatography . | NA | {
"id": "C0003075",
"name": "anionic",
"pos": [
13,
20
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
28,
31
]
} |
separation from an organic solution of tetraheptylammonium chloride may be accomplished by extraction with water under the following conditions , which promote transfer of a glucosiduronate to the aqueous phase : ( 1 ) an appropriate solvent ( diluent ) as the organic phase , ( 2 ) the presence in the two-phase mixture... | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
59,
67
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
327,
332
]
} |
separation from an organic solution of tetraheptylammonium chloride may be accomplished by extraction with water under the following conditions , which promote transfer of a glucosiduronate to the aqueous phase : ( 1 ) an appropriate solvent ( diluent ) as the organic phase , ( 2 ) the presence in the two-phase mixture... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
327,
332
]
} | {
"id": "C0022023",
"name": "ion",
"pos": [
481,
484
]
} |
light-scattering studies showed that both respiratory substrate and a permeant anion such as phosphate or acetate are required for rapid and massive entry of k ( + ) , which occurs in an electrophoretic process rather than in exchange for h ( + ) . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
79,
84
]
} | {
"id": "C0031603",
"name": "phosphate",
"pos": [
93,
102
]
} |
peptide hormones labelled with radioactive iodine were partitioned into the aqueous two-phase polymer systems developed by albertsson ( 1960 ) and the conditions required for separation of free from antibody-bound hormone have been worked out . | NA | {
"id": "C0597192",
"name": "peptide hormones",
"pos": [
0,
16
]
} | {
"id": "C0019932",
"name": "hormone",
"pos": [
214,
221
]
} |
dietary cholesterol induces a hemolytic anemia in guinea pigs , accompanied by changes in the lipid composition of red cells and of plasma lipoproteins . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
94,
99
]
} | {
"id": "C0023820",
"name": "lipoproteins",
"pos": [
139,
151
]
} |
the results show that cellular enlargement is associated with an increase in the basal lipolysis as well as the release of glycerol induced by salbutamol ( a beta ( 2 ) -receptor agonist ) , noradrenaline , adrenaline , and isopropyl-noradrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
191,
204
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
237,
247
]
} |
three glycosides of 13-hydroxydocosanoic acid isolated from candida bogoriensis were characterized by quantitating the amount of carbohydrate , acetate , and hydroxy acid in each , and by gas-liquid chromatography and mass spectrometry of their methyl ester , trimethylsilyl ether derivatives . | NA | {
"id": "C0017977",
"name": "glycosides",
"pos": [
6,
16
]
} | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
129,
141
]
} |
thin-layer chromatography revealed important differences among the plasmas from the three species , but all possessed hematosides and hexosamine-containing gangliosides . | NA | {
"id": "C0016897",
"name": "hematosides",
"pos": [
118,
129
]
} | {
"id": "C0017082",
"name": "gangliosides",
"pos": [
156,
168
]
} |
purification and characterization of lymphocyte mediators in cellular immunity : comparative studies on migration inhibitory factor ( mif ) chemotactic factor for macrophages and lymphotoxin . | NA | {
"id": "C0024297",
"name": "lymphocyte mediators",
"pos": [
37,
57
]
} | {
"id": "C0024320",
"name": "lymphotoxin",
"pos": [
179,
190
]
} |
reaction of alkylating mutagens and carcinogens with nucleic acids : detection and estimation of a small extent of methylation at o-6 of guanine in dna by methyl methanesulphonate in vitro . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
53,
66
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
148,
151
]
} |
developmental changes in rat adrenal tyrosine hydroxylase , dipamine- -hydroxylase and catecholamine levels : effect of denervation . | NA | {
"id": "C0041491",
"name": "tyrosine hydroxylase",
"pos": [
37,
57
]
} | {
"id": "C0020364",
"name": "hydroxylase",
"pos": [
71,
82
]
} |
the specific radioactivity of plasma d-glucose and the incorporation of ( 14 ) c into plasma l-lactate , liver glycogen and skeletal-muscle glycogen was measured as a function of time after the intraperitoneal injection of d- [ 6- ( 14 ) c ] glucose and d- [ 6- ( 3 ) h ] glucose into newborn , 2- , 10- and 30-day-old r... | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
105,
119
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
140,
148
]
} |
the specific radioactivity of plasma l-lactate and the incorporation of ( 14 ) c into plasma d-glucose , liver glycogen and skeletal-muscle glycogen were measured as a function of time after the intraperitoneal injection of l- [ u- ( 14 ) c ] lactate into 2- , 10- and 30-day-old rats . | NA | {
"id": "C0023902",
"name": "liver glycogen",
"pos": [
105,
119
]
} | {
"id": "C0017911",
"name": "glycogen",
"pos": [
140,
148
]
} |
this is because the method is applicable to complex mixtures of nucleotides in which such substances as ribonucleotides are present in very large excess over deoxyribonucleotides , and it is not necessary to equilibrate the nucleotide-precursor pool with radioactive phosphate . | NA | {
"id": "C0035548",
"name": "ribonucleotides",
"pos": [
104,
119
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
224,
234
]
} |
this is because the method is applicable to complex mixtures of nucleotides in which such substances as ribonucleotides are present in very large excess over deoxyribonucleotides , and it is not necessary to equilibrate the nucleotide-precursor pool with radioactive phosphate . | NA | {
"id": "C0011529",
"name": "deoxyribonucleotides",
"pos": [
158,
178
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
224,
234
]
} |
other polynucleotides and trna also exert an inhibitory effect that is prevented by albumin , but nucleotides have no effect . | NA | {
"id": "C0032550",
"name": "polynucleotides",
"pos": [
6,
21
]
} | {
"id": "C0028630",
"name": "nucleotides",
"pos": [
98,
109
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0022023",
"name": "ion",
"pos": [
113,
116
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0016327",
"name": "fluoride",
"pos": [
167,
175
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0038720",
"name": "sulphate",
"pos": [
178,
186
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
189,
197
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0006222",
"name": "bromide",
"pos": [
200,
207
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0028125",
"name": "nitrate",
"pos": [
210,
217
]
} |
as observed in other protein systems , lyotropic activity increased in the series formamide < urea < guanidinium ion , and in the guanidinium salts in the anion order fluoride < sulphate < chloride < bromide < nitrate < iodide . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
155,
160
]
} | {
"id": "C0021966",
"name": "iodide",
"pos": [
220,
226
]
} |
low activities of guanidinium fluoride and sulphate were attributable to counter-effects of the anions , which acted as structural stabilizers . | NA | {
"id": "C0016327",
"name": "fluoride",
"pos": [
30,
38
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
96,
102
]
} |
low activities of guanidinium fluoride and sulphate were attributable to counter-effects of the anions , which acted as structural stabilizers . | NA | {
"id": "C0038720",
"name": "sulphate",
"pos": [
43,
51
]
} | {
"id": "C0003075",
"name": "anions",
"pos": [
96,
102
]
} |
five glucocorticoids , when administered daily to rats for 5-7 days at a dosage of 5mg/kg , were in the following order of effectiveness with respect to their ability to decrease the weight gain of whole animals and the vastus lateralis , vastus medialis and gluteus medius muscles : corticosterone < prednisolone < tria... | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
316,
329
]
} | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
364,
387
]
} |
however , triamcinolone was as effective as triamcinolone acetonide in causing a significant effect at 0.05mg/kg , although it had a far lower catabolic potency than the acetonide . | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
10,
23
]
} | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
44,
67
]
} |
normal ribosomal function was renewed between 12 and 18h after the administration of triamcinolone and betamethasone at 5mg/kg , but decreased activity persisted for more than 48h after similar doses of dexamethasone or triamcinolone acetonide . | NA | {
"id": "C0040864",
"name": "triamcinolone",
"pos": [
85,
98
]
} | {
"id": "C0040866",
"name": "triamcinolone acetonide",
"pos": [
220,
243
]
} |
activation of the beta-receptors caused a small and inconsistent hyperpolarization which became more pronounced and also more reproducible on replacing the chloride content of the bathing fluid by the larger anion isethionate.8 . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
156,
164
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
208,
213
]
} |
drug interactions in experimental hepatic porphyria : a model for the exacerbation by drugs of human variegate porphyria . | NA | {
"id": "C0162533",
"name": "hepatic porphyria",
"pos": [
34,
51
]
} | {
"id": "C0162532",
"name": "variegate porphyria",
"pos": [
101,
120
]
} |
whereas the low incorporation of acids into total phospholipids reflected the relative stability of the major phospholipid fractions in sperm , the minor phospholipids , particularly phosphatidylinositol , showed comparatively high metabolic activity . | NA | {
"id": "C0771648",
"name": "of",
"pos": [
30,
32
]
} | {
"id": "C0031676",
"name": "phospholipids",
"pos": [
154,
167
]
} |
sodium dodecyl sulfate-polyacrylamide gel electrophoresis of solubilized membrane proteins reveals only two labeled protein bands out of the 15 present , and the presence of 50-1 x 10 ( 6 ) iodide atoms per ghost does not alter this pattern . | NA | {
"id": "C0025252",
"name": "membrane proteins",
"pos": [
73,
90
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
116,
123
]
} |
gas chromatography-mass spectrometry was used to quantitate serotonin , n-acetylserotonin , 5-methoxytryptamine , and melatonin in single rat pineal glands . | NA | {
"id": "C0036751",
"name": "serotonin",
"pos": [
60,
69
]
} | {
"id": "C0000589",
"name": "5-methoxytryptamine",
"pos": [
92,
111
]
} |
[ steroid saponins with more than one sugar chain . vi . lanatigoside and lanagitoside , two bisdesmosidic 22-hydroxyfurostanol glycosides from the leaves of digitalis lanata ehrh ] . | NA | {
"id": "C0007004",
"name": "sugar",
"pos": [
38,
43
]
} | {
"id": "C0017977",
"name": "glycosides",
"pos": [
128,
138
]
} |
[ analysis of the interaction of peripheral serotonin antagonists with tryptamine and n , n-dimethyltryptamine on rabbit electrocorticograms ] . | NA | {
"id": "C0041248",
"name": "tryptamine",
"pos": [
71,
81
]
} | {
"id": "C0027183",
"name": "dimethyltryptamine",
"pos": [
92,
110
]
} |
it is concluded that liver disease should be included among the constant features of the cryoglobulin-associated syndrome , and the speculation is advanced that in cryoglobulinaemic patients both cirrhosis and chronic hepatitis may be caused by the same pathogenic mechanism ( s ) . | NA | {
"id": "C0023895",
"name": "liver",
"pos": [
21,
26
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
196,
205
]
} |
the main determinant of brain tryptophan and serotonin concentrations does not appear to be plasma tryptophan alone , but the ratio of this amino acid to other plasma neutral amino acids ( that is , tyrosine , phenylalanine , leucine , isoleucine , and valine ) that compete with it for uptake into the brain . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
140,
150
]
} | {
"id": "C0301715",
"name": "neutral amino acids",
"pos": [
167,
186
]
} |
the evidence relating to intravascular coagulation in renal disease is reviewed , and it is suggested that there is a high incidence of localized fibrinogen or fibrin degradation in the kidney , which is related more to factors such as the presence of uraemia and microangiopathic haemolytic anaemia rather than to the d... | NA | {
"id": "C0022658",
"name": "renal disease",
"pos": [
54,
67
]
} | {
"id": "C0041948",
"name": "uraemia",
"pos": [
252,
259
]
} |
plasma adrenaline , noradrenaline , and free fatty acids were estimated before treatment , immediately after sedation with diazapam 0.2 mg/kg body weight in the phobic patients , during induction of oral anaesthesia , and during and after surgery . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
7,
17
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
20,
33
]
} |
[ so-called thrombotic microangiopathy of the kidney with bilateral kidney cortex necrosis during hemolytic-uremic ( nephropathic ) syndrome in a child ] . | NA | {
"id": "C0022656",
"name": "bilateral kidney cortex",
"pos": [
58,
81
]
} | {
"id": "C0022658",
"name": "nephropathic",
"pos": [
117,
129
]
} |
the 16s ( 18s ) ribosomal ribonucleic acids from a number of organisms were screened for the presence of ( some of ) the post-transcriptionally modified oligomers found in escherichia coli 16s ribosomal ribonucleic acid . | NA | {
"id": "C0035701",
"name": "ribosomal ribonucleic acids",
"pos": [
16,
43
]
} | {
"id": "C0035702",
"name": "16s ribosomal ribonucleic acid",
"pos": [
189,
219
]
} |
in the protein fraction , the acidic amino acids , glutamic and aspartic acid , and the neutral amino acids , glycine and alanine , predominated . | NA | {
"id": "C0815040",
"name": "acidic amino acids",
"pos": [
30,
48
]
} | {
"id": "C0004015",
"name": "aspartic acid",
"pos": [
64,
77
]
} |
the structural part responsible for this activity of lps is the lipid moiety ( lipid a ) , because the lipid a prepared from either the lps of escherichia coli or the endotoxic glycolipid of a heptose-less mutant ( r595 ) of salmonella minnesota affected mitochondrial oxidative phosphorylation as did lps , whereas the ... | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
79,
86
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
302,
305
]
} |
by sucrose gradient analysis and diethylaminoethyl-cellulose chromatography , the proteins initially made in response to putrescine appear to be composed of many classes , including membrane-bound proteins . | NA | {
"id": "C0033684",
"name": "proteins",
"pos": [
82,
90
]
} | {
"id": "C0025252",
"name": "membrane",
"pos": [
182,
190
]
} |
escherichia coli cells are shown to be attracted to the l-amino acids alanine , asparagine , aspartate , cysteine , glutamate , glycine , methionine , serine , and threonine , but not to arginine , cystine , glutamine , histidine , isoleucine , leucine , lysine , phenylalanine , tryptophan , tyrosine , or valine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
58,
69
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
270,
277
]
} |
escherichia coli cells are shown to be attracted to the l-amino acids alanine , asparagine , aspartate , cysteine , glutamate , glycine , methionine , serine , and threonine , but not to arginine , cystine , glutamine , histidine , isoleucine , leucine , lysine , phenylalanine , tryptophan , tyrosine , or valine . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
58,
69
]
} | {
"id": "C0017890",
"name": "glycine",
"pos": [
128,
135
]
} |
( i ) there was synthesis of fatty acids at the predeprivation rate even though the fatty acids synthesized accumulated as free fatty acids rather than as esterified fatty acids ; | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
29,
40
]
} | {
"id": "C0015688",
"name": "free fatty acids",
"pos": [
123,
139
]
} |
spectroscopic microanalysis of the element-characteristic x rays produced by a scanning electron microprobe was employed to detect calcium and carbon in both intact and thin-sectioned spores of bacillus cereus t and b. megaterium qm b1551 . | NA | {
"id": "C0013879",
"name": "element",
"pos": [
35,
42
]
} | {
"id": "C0007009",
"name": "carbon",
"pos": [
143,
149
]
} |
the purified enzyme could readily synthesize sah from adenosine and homocysteine , but could hydrolyze only negligible amounts of sah . | NA | {
"id": "C0036001",
"name": "sah",
"pos": [
45,
48
]
} | {
"id": "C0001443",
"name": "adenosine",
"pos": [
54,
63
]
} |
a number of compounds structurally similar to adenosine and homocysteine were found to inhibit synthesis of sah from adenosine and homocysteine . | NA | {
"id": "C0001443",
"name": "adenosine",
"pos": [
46,
55
]
} | {
"id": "C0036001",
"name": "sah",
"pos": [
108,
111
]
} |
colchicine , demecolcine , and vinblastine , compounds known to disaggregate microtubules , i.e. , have an effect opposite to that of d ( 2 ) o , inhibited the release of histamine and counteracted the effects of d ( 2 ) o . | NA | {
"id": "C0009262",
"name": "colchicine",
"pos": [
0,
10
]
} | {
"id": "C0011259",
"name": "demecolcine",
"pos": [
13,
24
]
} |
these findings suggest that transfer factor acts on the immunocompetent cells that respond to antigens with lymphokine production , but has little , if any , effect on cells that respond to antigens by blastogenesis . | NA | {
"id": "C0040673",
"name": "transfer factor",
"pos": [
28,
43
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
108,
118
]
} |
failure of transfer factor to produce positive skin tests or mif production in a patient with nezelof 's syndrome may be evidence that lymphokine-producing cells are thymus derived . | NA | {
"id": "C0040673",
"name": "transfer factor",
"pos": [
11,
26
]
} | {
"id": "C0024297",
"name": "lymphokine",
"pos": [
135,
145
]
} |
since rheumatoid nodules grow centrifugally at the expense of the palisading fibroblast layer it seems possible that the central necrotic areas are caused by release of collagenase and protease from the highly cellular palisading zone resulting in the destruction of the extracellular collagen matrix . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
77,
87
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
276,
284
]
} |
a protein that binds catecholamines with a specificity parallel to that of their in vivo effects on cardiac contractility ( isoproterenol > epinephrine or norepinephrine > dopamine > dihydroxyphenylalanine ) was solubilized from a microsomal fraction of canine ventricular myocardium . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
21,
35
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
124,
137
]
} |
a protein that binds catecholamines with a specificity parallel to that of their in vivo effects on cardiac contractility ( isoproterenol > epinephrine or norepinephrine > dopamine > dihydroxyphenylalanine ) was solubilized from a microsomal fraction of canine ventricular myocardium . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
21,
35
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
183,
205
]
} |
a protein that binds catecholamines with a specificity parallel to that of their in vivo effects on cardiac contractility ( isoproterenol > epinephrine or norepinephrine > dopamine > dihydroxyphenylalanine ) was solubilized from a microsomal fraction of canine ventricular myocardium . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
140,
151
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
155,
169
]
} |
the psoralen-dna is not a potent inhibitor , but competes with single-stranded dna from bacteriophage fd for the recbc dnase to roughly the same extent as does normal duplex dna . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
63,
82
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
174,
177
]
} |
biochemical method for inserting new genetic information into dna of simian virus 40 : circular sv40 dna molecules containing lambda phage genes and the galactose operon of escherichia coli . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
62,
65
]
} | {
"id": "C0012925",
"name": "circular",
"pos": [
87,
95
]
} |
we have developed methods for covalently joining duplex dna molecules to one another and have used these techniques to construct circular dimers of sv40 dna and to insert a dna segment containing lambda phage genes and the galactose operon of e. coli into sv40 dna . | NA | {
"id": "C0012925",
"name": "circular",
"pos": [
129,
137
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
261,
264
]
} |
the method involves : ( a ) converting circular sv40 dna to a linear form , ( b ) adding single-stranded homodeoxypolymeric extensions of defined composition and length to the 3 ' ends of one of the dna strands with the enzyme terminal deoxynucleotidyl transferase ( c ) adding complementary homodeoxypolymeric extension... | NA | {
"id": "C0012854",
"name": "dna molecules",
"pos": [
372,
385
]
} | {
"id": "C0012925",
"name": "circular dna",
"pos": [
558,
570
]
} |
acylation of transfer rna with labeled amino acids and determination of codon responses of aminoacyl-trnas demonstrate that a species of seryl-trna and a species of arginyl-trna recognize the codon uga . | NA | {
"id": "C0002520",
"name": "amino acids",
"pos": [
39,
50
]
} | {
"id": "C0035714",
"name": "aminoacyl-trnas",
"pos": [
91,
106
]
} |
[ activity in vitro of some semisynthetic penicillins produced in antibiotic factories of jassy , on pathogenic staphylococci . ii . action of cloxacillin and dicloxacillin ] . | NA | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
143,
154
]
} | {
"id": "C0012093",
"name": "dicloxacillin",
"pos": [
159,
172
]
} |
micro fluorometric binding studies of fluorescein-albumin conjugates and determination of fluorescein-protein conjugates in single fibroblasts . | NA | {
"id": "C0001924",
"name": "albumin",
"pos": [
50,
57
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
102,
109
]
} |
comparative studies on the transport of aminopterin , methotrexate , and methasquin by the l1210 leukemia cell . | NA | {
"id": "C0002583",
"name": "aminopterin",
"pos": [
40,
51
]
} | {
"id": "C0025677",
"name": "methotrexate",
"pos": [
54,
66
]
} |
isoenzyme spectrum of hapalopilus nidulans : composition of a ( leucine ) aminopeptidase from active subunits -- characterization of enzymes with narrow substrate specificity ] . | NA | {
"id": "C0022173",
"name": "isoenzyme",
"pos": [
0,
9
]
} | {
"id": "C0014442",
"name": "enzymes",
"pos": [
133,
140
]
} |
[ a cytochemical study of nucleic acids ( dna and rna ) and glycogen in the leukocytes of young children with the toxic form of pneumonia ] . | NA | {
"id": "C0028606",
"name": "nucleic acids",
"pos": [
26,
39
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
42,
45
]
} |
studies of the l1210 antileukemic activity of o-2,2'-cyclocytidine , monoacetate ( anhydro-ara-c ; nsc-129220 ) -- comparison with cytosine arabinoside ( nsc-63878 ) with respect to treatment schedule dependency . | NA | {
"id": "C0010557",
"name": "anhydro-ara-c",
"pos": [
83,
96
]
} | {
"id": "C0010711",
"name": "cytosine arabinoside",
"pos": [
131,
151
]
} |
studies on the product of the reaction between activated hageman factor ( factor xii ) and plasma thromboplastin antecedent ( factor xi ) . | NA | {
"id": "C0015527",
"name": "activated hageman factor",
"pos": [
47,
71
]
} | {
"id": "C0015525",
"name": "factor",
"pos": [
126,
132
]
} |
[ blood volume determination in mechanic intestinal obstruction . ( a contribution on the problem of volumetry in ileus ) ] . | NA | {
"id": "C0021843",
"name": "intestinal obstruction",
"pos": [
41,
63
]
} | {
"id": "C1258215",
"name": "ileus",
"pos": [
114,
119
]
} |
ampicillin was slightly more active than penicillin g : all isolates were inhibited by 0.5mug./ml . or less . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
0,
10
]
} | {
"id": "C0030827",
"name": "penicillin g",
"pos": [
41,
53
]
} |
[ studies on experimental cadmium poisoning . i. effect of pre-administration of heavy metals and vitamins on acute cadmium poisoning in mice ] . | NA | {
"id": "C0006632",
"name": "cadmium",
"pos": [
26,
33
]
} | {
"id": "C0347988",
"name": "heavy metals",
"pos": [
81,
93
]
} |
effect of the number of hapten molecules introduced in homologous protein on antibody synthesis against the hapten and the new antigenic determinants . | NA | {
"id": "C0018593",
"name": "hapten",
"pos": [
24,
30
]
} | {
"id": "C0003316",
"name": "antigenic",
"pos": [
127,
136
]
} |
[ the behaviour of blood sugar and serum insulin ( iri ) after oral administration of glucose in different stages of myocardial infarction ] . | NA | {
"id": "C0005802",
"name": "blood sugar",
"pos": [
19,
30
]
} | {
"id": "C0017725",
"name": "glucose",
"pos": [
86,
93
]
} |
mg-excess ( 9.3 mm ) , noradrenaline and adrenaline were capable of reducing the increase of acetylcholine release from cortical slices evoked by ouabain , phmb or by ca replacement by ba , but not by na removal.7 . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
23,
36
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
41,
51
]
} |
the effect of intracarotid epinephrine , norepinephrine , and angiotensin on the regional cerebral blood flow in man . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
27,
38
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
41,
55
]
} |
a double-blind comparison of slow-release tetracycline and tetracycline hydrochloride in purulent exacerbations of chronic bronchitis . | NA | {
"id": "C0039644",
"name": "tetracycline",
"pos": [
42,
54
]
} | {
"id": "C0546879",
"name": "tetracycline",
"pos": [
59,
71
]
} |
isolation of prekallikrein activator from guinea pig serum or plasma adsorbed to immune precipitates or celite : possible relationship to hageman factor . | NA | {
"id": "C0015527",
"name": "prekallikrein activator",
"pos": [
13,
36
]
} | {
"id": "C0015525",
"name": "hageman factor",
"pos": [
138,
152
]
} |
conversion of hageman factor ( factor xii ) of the guinea pig to prekallikrein activator and inhibition of the formed kallikrein by a natural plasma inhibitor . | NA | {
"id": "C0015525",
"name": "factor xii",
"pos": [
31,
41
]
} | {
"id": "C0015527",
"name": "prekallikrein",
"pos": [
65,
78
]
} |
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