text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
1962.-the nucleic acid of fowlpox virus obtained from purified inclusions was identified as deoxyribonucleic acid ( dna ) . | NA | {
"id": "C0028606",
"name": "nucleic acid",
"pos": [
10,
22
]
} | {
"id": "C0012854",
"name": "deoxyribonucleic acid",
"pos": [
92,
113
]
} |
[ demineralised water . 7. the possibility of bacterial growth in purified water and the influence of containers on it ] . | NA | {
"id": "C0043047",
"name": "water",
"pos": [
16,
21
]
} | {
"id": "C0991883",
"name": "purified water",
"pos": [
66,
80
]
} |
a comparative study of the biological value of sesame cake , sesame protein isolate and sesame protein hydrolysate . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
68,
75
]
} | {
"id": "C0033631",
"name": "protein hydrolysate",
"pos": [
95,
114
]
} |
some reactions of deuterium atoms in the radiolysis of amino acids , peptides , thiols , and alcohols in heavy water . | NA | {
"id": "C0011744",
"name": "deuterium",
"pos": [
18,
27
]
} | {
"id": "C0011745",
"name": "heavy water",
"pos": [
105,
116
]
} |
[ studies on the degradation , distribution and excretion of tritium-labelled cyclophosphamide in the human body . ii . metabolism of the cytostatic in vivo ] . | NA | {
"id": "C0221102",
"name": "excretion",
"pos": [
48,
57
]
} | {
"id": "C0025519",
"name": "metabolism",
"pos": [
120,
130
]
} |
[ progesterone , delta-4-pregnen-20alpha-ol-3-one , delta 4-pregnen-20beta-ol-3-one and 17alpha-hydroxy-progesterone in the plasma of the umbilical vein and the umbilical artery ] . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
2,
14
]
} | {
"id": "C0020387",
"name": "17alpha-hydroxy-progesterone",
"pos": [
88,
116
]
} |
the effect of adrenaline , noradrenaline , acetylcholine , histamine and 5-hydroxytryptamine on the rat mammary gland has also been tested . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
14,
24
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
27,
40
]
} |
[ comparative studies on the effect of reserpine , deserpidine and deserpidine derivatives on the absorption of serotonin by the thrombocytes ] . | NA | {
"id": "C0035179",
"name": "reserpine",
"pos": [
39,
48
]
} | {
"id": "C0175158",
"name": "absorption",
"pos": [
98,
108
]
} |
the thread model contracts also in the presence of dehydroascorbic acid , cystine , oxidized glutathione , or other oxidizing agents , and this contraction is reversed by reducing agents such as cysteine or ascorbic acid . | NA | {
"id": "C0011177",
"name": "dehydroascorbic acid",
"pos": [
51,
71
]
} | {
"id": "C0003968",
"name": "ascorbic acid",
"pos": [
207,
220
]
} |
the persistence of bacterial antigens is postulated to constitute a major antigenic stimulus responsible for active immunity in experimental hematogenous pyelonephritis . | NA | {
"id": "C0003321",
"name": "bacterial antigens",
"pos": [
19,
37
]
} | {
"id": "C0003320",
"name": "antigenic",
"pos": [
74,
83
]
} |
since k. pneumoniae failed to evoke capsular antibodies in the rat , resistance to infection with k. pneumoniae was produced only by means of passively transferred concentrated rabbit antiserum and not by prior infection . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
45,
55
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
184,
193
]
} |
investigation of the spectrophotometric method of measuring the ferric ion yield in the ferrous sulfate dosimeter . | NA | {
"id": "C0302583",
"name": "ferric ion",
"pos": [
64,
74
]
} | {
"id": "C0060282",
"name": "ferrous sulfate",
"pos": [
88,
103
]
} |
chick embryos were sacrificed at intervals after simultaneous injection of bapn and proline-c ( 14 ) , the collagen separated into neutral salt-extractable and residue fractions , and total hydroxyproline and hydroxyproline specific radioactivity determined in each fraction . | NA | {
"id": "C0033382",
"name": "proline",
"pos": [
84,
91
]
} | {
"id": "C0020388",
"name": "hydroxyproline",
"pos": [
209,
223
]
} |
when measured simultaneously , selenium-75 selenomethionine accumulated identically with sulfur-35 methionine across everted hamster intestinal sacs in the presence of carrier methionine . | NA | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
43,
59
]
} | {
"id": "C0025646",
"name": "methionine",
"pos": [
176,
186
]
} |
the apparent k ( m ) for l-methionine transport was 0.8 x 10 ( -3 ) m , as calculated from the beta emissions of s ( 35 ) -methionine or the gamma emissions of se ( 75 ) -selenomethionine . | NA | {
"id": "C0025646",
"name": "methionine",
"pos": [
27,
37
]
} | {
"id": "C0036584",
"name": "selenomethionine",
"pos": [
171,
187
]
} |
calcium , phosphorus and nitrogen metabolism in rickets , osteomalacia and hyperparathyroidism complicating chronic uremia and in the osteomalacia of the adult fanconi syndrome . | NA | {
"id": "C0035579",
"name": "rickets",
"pos": [
48,
55
]
} | {
"id": "C0029442",
"name": "osteomalacia",
"pos": [
134,
146
]
} |
effect of alpha-methyl-3,4-dihydroxyphenylalanine ( methyldopa ) , reserpine and related agents on some vascular responses in the dog . | NA | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
27,
49
]
} | {
"id": "C0025741",
"name": "methyldopa",
"pos": [
52,
62
]
} |
[ effect of high temperatures on the central nervous system -- changes in the concentration of noradrenalin and adrenalin in the brain stem in animals exposed to high temperatures ] . | NA | {
"id": "C0028351",
"name": "noradrenalin",
"pos": [
95,
107
]
} | {
"id": "C0014563",
"name": "adrenalin",
"pos": [
112,
121
]
} |
[ on the detection of local and systemic actions of heparin as well as heparinoid ointments ] . | NA | {
"id": "C0019134",
"name": "heparin",
"pos": [
52,
59
]
} | {
"id": "C0019142",
"name": "heparinoid",
"pos": [
71,
81
]
} |
the agglutinating antigen 51 was isolated from all strains from patients with urinary infections and abundant pyuria . | NA | {
"id": "C0042029",
"name": "urinary infections",
"pos": [
78,
96
]
} | {
"id": "C0034359",
"name": "pyuria",
"pos": [
110,
116
]
} |
[ effect of glutamic acid and caffeine on the content of glutamine , ammonia , glutamic and adenosinetriphosphoric acids in the greater hemispheres of the brain ] . | NA | {
"id": "C0061472",
"name": "glutamic acid",
"pos": [
12,
25
]
} | {
"id": "C0017797",
"name": "glutamine",
"pos": [
57,
66
]
} |
effect of monoamine oxidase inhibitors and pyrogallol on the pressor response to adrenaline , noradrenaline , normetanephrine and tyramine in the rat . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
81,
91
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
94,
107
]
} |
effect of monoamine oxidase inhibitors and pyrogallol on the pressor response to adrenaline , noradrenaline , normetanephrine and tyramine in the rat . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
94,
107
]
} | {
"id": "C0028385",
"name": "normetanephrine",
"pos": [
110,
125
]
} |
[ saponins and sapogenins . xiii . isolation of balanitesin , a new steroid saponin for the seed kernels of balanites roxburghii planch ] . | NA | {
"id": "C0036188",
"name": "sapogenins",
"pos": [
15,
25
]
} | {
"id": "C0038317",
"name": "steroid",
"pos": [
68,
75
]
} |
[ relation of some indices in the blood to the state of the lungs in patients with silicosis and anthracosilicosis ] . | NA | {
"id": "C0037116",
"name": "silicosis",
"pos": [
83,
92
]
} | {
"id": "C0003164",
"name": "anthracosilicosis",
"pos": [
97,
114
]
} |
[ paper chromatography in the practical study of the hydrolysis of some alkaloid esters . ii . alkaloids of the cocaine , aconitine and eserine groups ] . | NA | {
"id": "C0002062",
"name": "alkaloids",
"pos": [
95,
104
]
} | {
"id": "C0001159",
"name": "aconitine",
"pos": [
122,
131
]
} |
[ serological and clinical studies on virus diseases of the respiratory tract . iv . epidemiological observations on respiratory tract diseases during the years 1957-1961 ] . | NA | {
"id": "C0035204",
"name": "diseases of the respiratory tract",
"pos": [
44,
77
]
} | {
"id": "C0035242",
"name": "respiratory tract diseases",
"pos": [
117,
143
]
} |
[ a new basis for the scale of atomic weights of natural elements and isotopes -- carbon isotope c12 ] . | NA | {
"id": "C0022262",
"name": "isotopes",
"pos": [
70,
78
]
} | {
"id": "C0007017",
"name": "carbon isotope",
"pos": [
82,
96
]
} |
the anaesthetic management of children with glycogen-storage disease type iia ( pompe 's disease ) presents a variety of challenges . | NA | {
"id": "C0017919",
"name": "glycogen-storage disease",
"pos": [
44,
68
]
} | {
"id": "C0017921",
"name": "pompe 's disease",
"pos": [
80,
96
]
} |
similarly , chronic infusion of sotalol ( 1.5 mg x day-1 x rat-1 ) through an osmotic pump for 12 days in doca-salt ht rats significantly reduced ne and epinephrine ( e ) plasma levels compared with those observed in untreated doca-salt ht rats . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
146,
148
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
153,
164
]
} |
however , as in any other immunological system , routine verification of the specificity of the latex reagents against standard enterotoxins and toxin-free food extracts is necessary . | NA | {
"id": "C0014372",
"name": "enterotoxins",
"pos": [
128,
140
]
} | {
"id": "C0040549",
"name": "toxin",
"pos": [
145,
150
]
} |
the pia-arachnoid cells were then removed with detergent and base , leaving behind an ecm enriched in laminin , fibronectin , types i and iv collagen , and procollagen iii . | NA | {
"id": "C0009325",
"name": "collagen",
"pos": [
141,
149
]
} | {
"id": "C0033235",
"name": "procollagen",
"pos": [
156,
167
]
} |
this is the first reported outbreak of legionnaires ' disease caused by l. dumoffii , and it is the first time that nosocomial legionellosis has been linked to contaminated distilled water in canada . | NA | {
"id": "C0023241",
"name": "legionnaires",
"pos": [
39,
51
]
} | {
"id": "C0023240",
"name": "legionellosis",
"pos": [
127,
140
]
} |
over half ( 60 % ) had an arrhythmia , including sinus tachycardia ( 42 % ) , premature atrial and ventricular contractions ( 13 % ) , atrial fibrillation ( 3 % ) , and atrial flutter ( 1 % ) . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
26,
36
]
} | {
"id": "C0004238",
"name": "atrial",
"pos": [
169,
175
]
} |
over half ( 60 % ) had an arrhythmia , including sinus tachycardia ( 42 % ) , premature atrial and ventricular contractions ( 13 % ) , atrial fibrillation ( 3 % ) , and atrial flutter ( 1 % ) . | NA | {
"id": "C0003811",
"name": "arrhythmia",
"pos": [
26,
36
]
} | {
"id": "C0004239",
"name": "atrial flutter",
"pos": [
169,
183
]
} |
five of the antisera reacted with p21 , and of these , anti-serine , -valine , -arginine , and -aspartate peptide antibodies were specific for their cognate protein . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
12,
20
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
114,
124
]
} |
the human leukemia cell lines hl-60 , kg-1 , klm-2 , ml-3 , thp-1 , and u-937 were treated with the phorbol ester 12-o-tetradecanoylphorbol 13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
100,
113
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol 13-acetate",
"pos": [
114,
150
]
} |
n , n ' , n '' -triethylenephosphoramide , an active metabolite of thiotepa observed in all fluids , appeared to have a much slower total body clearance than thiotepa . | NA | {
"id": "C0039533",
"name": "triethylenephosphoramide",
"pos": [
16,
40
]
} | {
"id": "C0039871",
"name": "thiotepa",
"pos": [
158,
166
]
} |
we have examined a number of human adult tumors for igf messenger rna ( mrna ) expression and found igf-ii mrna levels were consistently elevated in two types , colon carcinoma and liposarcoma . | NA | {
"id": "C0037657",
"name": "igf",
"pos": [
52,
55
]
} | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
100,
106
]
} |
over 90 % of liposarcomas examined contained greatly elevated levels of igf-ii mrna while control tissue ( adipose ) contained very low or undetectable igf mrna levels . | NA | {
"id": "C0021666",
"name": "igf-ii",
"pos": [
72,
78
]
} | {
"id": "C0037657",
"name": "igf",
"pos": [
152,
155
]
} |
when the phorbol ester 12-o-tetradecanoylphorbol-13-acetate was used as a positive control , the extent of dye transfer was reduced to 2.9 +/- 2.1 cells within 2 h after incubation with 12-o-tetradecanoylphorbol-13-acetate ( 100 ng/ml ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
9,
22
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
186,
222
]
} |
we investigated the ability of nine fibroblast cell strains from patients with the hereditary form of retinoblastoma ( rb ) to handle various types of dna-damaging agents and compared the results with those obtained in nine normal strains . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
16,
19
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
36,
46
]
} |
the results suggest that normal human fibroblast cell strains exhibit a wide response to dna-damaging agents , especially chemical agents . | NA | {
"id": "C0007634",
"name": "normal",
"pos": [
25,
31
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
38,
48
]
} |
mcf-7 human mammary epithelial cells are known to express three distinct cytoskeletal intermediate filament proteins designated numbers 8 ( mr 52,000 ) , 18 ( mr 45,000 ) , and 19 ( mr 40,000 ) keratin . | NA | {
"id": "C0021769",
"name": "intermediate filament proteins",
"pos": [
86,
116
]
} | {
"id": "C0010803",
"name": "keratin",
"pos": [
194,
201
]
} |
using immunofluorescence , the 5e8 antibody was observed to stain many different human lung tumor cell lines and surgically excised human lung tumors including squamous cell carcinomas , adenocarcinomas , alveolar carcinomas , and a portion of the large cell tumors tested . | NA | {
"id": "C0001418",
"name": "adenocarcinomas",
"pos": [
187,
202
]
} | {
"id": "C0007120",
"name": "alveolar carcinomas",
"pos": [
205,
224
]
} |
the latter cell lines exhibit binding sites for csf-1 , suggesting that this colony stimulating factor might also have an embryological role in placental development . | NA | {
"id": "C0079784",
"name": "csf-1",
"pos": [
48,
53
]
} | {
"id": "C0009392",
"name": "colony stimulating factor",
"pos": [
77,
102
]
} |
the ras proteins are found at the plasma membrane , bind guanine nucleotides gdp and gtp and possess a gtpase activity . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
57,
64
]
} | {
"id": "C0018340",
"name": "gdp",
"pos": [
77,
80
]
} |
the ras proteins are found at the plasma membrane , bind guanine nucleotides gdp and gtp and possess a gtpase activity . | NA | {
"id": "C0018328",
"name": "guanine",
"pos": [
57,
64
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
103,
106
]
} |
histological diagnosis of the tumors was as follows : teratoma ( 3 cases ) , medulloblastoma ( 3 ) , glioblastoma ( 2 ) , astrocytoma ( 2 ) , ependymoma ( 2 ) , craniopharyngioma ( 1 ) , choroid plexus papilloma ( 1 ) , hamartoma ( 1 ) , lipoma ( 1 ) , melanotic progonoma ( 1 ) , and an undetermined type , probably med... | NA | {
"id": "C0027651",
"name": "tumors",
"pos": [
30,
36
]
} | {
"id": "C0018552",
"name": "hamartoma",
"pos": [
220,
229
]
} |
histological diagnosis of the tumors was as follows : teratoma ( 3 cases ) , medulloblastoma ( 3 ) , glioblastoma ( 2 ) , astrocytoma ( 2 ) , ependymoma ( 2 ) , craniopharyngioma ( 1 ) , choroid plexus papilloma ( 1 ) , hamartoma ( 1 ) , lipoma ( 1 ) , melanotic progonoma ( 1 ) , and an undetermined type , probably med... | NA | {
"id": "C0017636",
"name": "glioblastoma",
"pos": [
101,
113
]
} | {
"id": "C0004114",
"name": "astrocytoma",
"pos": [
122,
133
]
} |
patients with all forms of angina , stable effort and unstable rest angina , and those with coronary artery spasm have very frequent episodes of silent myocardial ischemia during ordinary activity . | NA | {
"id": "C0002962",
"name": "angina",
"pos": [
27,
33
]
} | {
"id": "C0002965",
"name": "unstable",
"pos": [
54,
62
]
} |
a 50 % decrease in adenine nucleotides and a 60 % decrease in adenosine triphosphate concentration was found in glucose perfused myopathic syrian hamster heart ( 240 days old ) whereas there was an 18 % decrease and 40 % decrease respectively in acidotic healthy syrian hamster heart re-equilibrated with a physiological... | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
19,
38
]
} | {
"id": "C0001480",
"name": "adenosine",
"pos": [
62,
71
]
} |
if a substrate such as pyruvate or ribose was used with either model cardiac performance returned to near normal , although adenine nucleotide and adenosine triphosphate concentrations were further depressed . | NA | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
124,
142
]
} | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
147,
169
]
} |
like the myopathic hearts the re-equilibrated acidotic hearts had high myocardial pyruvate concentrations , above normal ratios of phosphocreatine to creatine , and near normal oxygen consumption , developed pressure , dp/dt , and cyclic adenosine monophosphate concentrations when re-equilibrated with a medium containi... | NA | {
"id": "C0031634",
"name": "phosphocreatine",
"pos": [
131,
146
]
} | {
"id": "C0010286",
"name": "creatine",
"pos": [
150,
158
]
} |
like the myopathic hearts the re-equilibrated acidotic hearts had high myocardial pyruvate concentrations , above normal ratios of phosphocreatine to creatine , and near normal oxygen consumption , developed pressure , dp/dt , and cyclic adenosine monophosphate concentrations when re-equilibrated with a medium containi... | NA | {
"id": "C0001455",
"name": "cyclic adenosine monophosphate",
"pos": [
231,
261
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
393,
411
]
} |
like the myopathic hearts the re-equilibrated acidotic hearts had high myocardial pyruvate concentrations , above normal ratios of phosphocreatine to creatine , and near normal oxygen consumption , developed pressure , dp/dt , and cyclic adenosine monophosphate concentrations when re-equilibrated with a medium containi... | NA | {
"id": "C0001480",
"name": "adenosine triphosphate",
"pos": [
366,
388
]
} | {
"id": "C0001413",
"name": "adenine nucleotide",
"pos": [
393,
411
]
} |
these results support the hypothesis that m1 muscarinic coronary receptors are responsible for the redistribution of blood flow to the subendocardium ( increased endocardial to epicardial blood flow ratio ) during cholinergic coronary vasodilatation , whereas both m1 and m2 receptors are involved in increasing myocardi... | NA | {
"id": "C0034826",
"name": "muscarinic",
"pos": [
45,
55
]
} | {
"id": "C0384752",
"name": "m2 receptors",
"pos": [
272,
284
]
} |
a 11 mmol x litre-1 dose of l-propionylcarnitine and l-acetylcarnitine significantly improved the recovery of cardiac output after 90 min of ischaemia and 15 min of reperfusion , but l-carnitine did not . | NA | {
"id": "C0001040",
"name": "l-acetylcarnitine",
"pos": [
53,
70
]
} | {
"id": "C0007258",
"name": "l-carnitine",
"pos": [
183,
194
]
} |
the rates at which the amount of neurohypophysial hormone and opioid peptides decreased , and the changes in the ratios between the amount of vasopressin or oxytocin and opioid peptide in the neurohypophysis after dehydration and in the incubation medium after depolarization in vitro cast some doubt on , and can be exp... | NA | {
"id": "C0032017",
"name": "neurohypophysial hormone",
"pos": [
33,
57
]
} | {
"id": "C0030095",
"name": "oxytocin",
"pos": [
157,
165
]
} |
antisera raised against rat somatostatin cryptic peptide ( rscp ; corresponding to amino acids 63-77 of rat pro-somatostatin ) , somatostatin-28- ( 1-12 ) and somatostatin-28- ( 17-28 ) were used to compare the morphological distribution of these pro-somatostatin-derived sequences within the gastroenteropancreatic syst... | NA | {
"id": "C0037659",
"name": "somatostatin",
"pos": [
28,
40
]
} | {
"id": "C0074854",
"name": "somatostatin-28",
"pos": [
159,
174
]
} |
in the submandibular gland the small neutral amino acid l-serine and the aromatic amino acid l-phenylalanine were localized to central acinar cells , demilunar cells and ductal cells . | NA | {
"id": "C0301715",
"name": "neutral amino acid",
"pos": [
37,
55
]
} | {
"id": "C0036720",
"name": "serine",
"pos": [
58,
64
]
} |
in the submandibular gland the small neutral amino acid l-serine and the aromatic amino acid l-phenylalanine were localized to central acinar cells , demilunar cells and ductal cells . | NA | {
"id": "C0301713",
"name": "aromatic amino acid",
"pos": [
73,
92
]
} | {
"id": "C0031453",
"name": "phenylalanine",
"pos": [
95,
108
]
} |
to understand the role of proteinases in tumor invasion , the effects of inhibitors of metallo- , serine- , and cysteine-proteinases on this process were studied using 125i-iododeoxyuridine-labeled b16/bl6 cells grown on human amnion basement membrane . | NA | {
"id": "C0030940",
"name": "proteinases",
"pos": [
26,
37
]
} | {
"id": "C2717970",
"name": "cysteine-proteinases",
"pos": [
112,
132
]
} |
transfection of a full-length cdna in mouse fibroblasts results in stable expression of ngf receptors that are recognized by monoclonal antibodies to the human ngf receptor and that bind [ 125i ] ngf . | NA | {
"id": "C0132173",
"name": "ngf receptors",
"pos": [
88,
101
]
} | {
"id": "C0254837",
"name": "ngf receptor",
"pos": [
160,
172
]
} |
no effect on mhc class i antigen expression was found when the n-myc gene was expressed in rat fibroblasts , indicating that some of the effects caused by n-myc gene amplification are cell-type-specific . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
95,
106
]
} | {
"id": "C0007634",
"name": "cell-type",
"pos": [
184,
193
]
} |
tissue-specific modulation of hormone secretory pathways appears to be a novel response to developmentally induced changes in the requirements for a peptide hormone . | NA | {
"id": "C0019932",
"name": "hormone",
"pos": [
30,
37
]
} | {
"id": "C0597192",
"name": "peptide hormone",
"pos": [
149,
164
]
} |
bombesin caused a rapid transfer of 3h from the lipid inositol pool of prelabeled cells into inositol phosphates . | NA | {
"id": "C0021547",
"name": "inositol",
"pos": [
54,
62
]
} | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
93,
112
]
} |
in the reaction observed , the 3'oh end of one single-stranded dna molecule primes dna synthesis using a double-stranded dna molecule of homologous sequence as the template . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
47,
66
]
} | {
"id": "C0012854",
"name": "double-stranded dna",
"pos": [
105,
124
]
} |
kruppel ( kr ) , a segmentation gene of drosophila , encodes a protein sharing structural features of the dna-binding `` '' finger motif '' '' of tfiiia , a xenopus transcription factor . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
63,
70
]
} | {
"id": "C0040648",
"name": "transcription fact",
"pos": [
165,
183
]
} |
a conversion-dependent covalent binding to dna was observed in incubations with added dna which was 0.2 times the amount of binding to protein ( 37 pmol/mg dna ) . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
0,
1
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
156,
159
]
} |
this study examines the relationship between unbalanced growth , dnase ii activity , dna breakage and cell survival during the exposure of l5178y cells to hydroxyurea ( hu ) , excess thymidine ( dthr ) or hu with excess of four deoxyribonucleosides ( dnr ) . | NA | {
"id": "C0040077",
"name": "thymidine",
"pos": [
183,
192
]
} | {
"id": "C0011528",
"name": "deoxyribonucleosides",
"pos": [
228,
248
]
} |
glutathione readily reacted with p , p'-biphenoquinone , the principal oxidation product of p , p'-biphenol in the hrp-hydrogen peroxide system and resulted in the formation of several glutathione conjugates , p , p'-biphenol and small amounts of oxidized glutathione . | NA | {
"id": "C0017817",
"name": "glutathione",
"pos": [
0,
11
]
} | {
"id": "C0061516",
"name": "oxidized",
"pos": [
247,
255
]
} |
the spectrum of myeloproliferative disorders including myelofibrosis , myeloid metaplasia , and megakaryoblastic leukemia is seen in these patients . | NA | {
"id": "C0027022",
"name": "myeloproliferative",
"pos": [
16,
34
]
} | {
"id": "C0001815",
"name": "myeloid metaplasia",
"pos": [
71,
89
]
} |
since unsaturated fatty acids have been shown to control cell division experimentally the fatty acid composition in human mammary cancers as compared with the healthy surrounding tissue was studied . | NA | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
6,
29
]
} | {
"id": "C0015684",
"name": "fatty acid",
"pos": [
90,
100
]
} |
in the phospholipid fatty acids of mammary cancers there was a marked increase in the relative amounts of unsaturated fatty acids , especially arachidonic acid , while saturated fatty acids were decreased , as compared with a healthy reference breast tissue or lipomas . | NA | {
"id": "C0015684",
"name": "fatty acids",
"pos": [
20,
31
]
} | {
"id": "C0015690",
"name": "unsaturated fatty acids",
"pos": [
106,
129
]
} |
we investigated possible mechanisms associated with promotion of hepatocarcinogenesis by the synthetic estrogens mestranol ( m ) and ethinyl estradiol ( ee ) . | NA | {
"id": "C0025506",
"name": "mestranol",
"pos": [
113,
122
]
} | {
"id": "C0015011",
"name": "ethinyl",
"pos": [
133,
140
]
} |
these findings indicate that i3c inhibition of afb1 hepatocarcinogenesis in trout involves substantial changes in the pharmacokinetics of carcinogen distribution , metabolism and elimination , leading to significantly reduced initial hepatic-nuclear dna damage in vivo . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
164,
174
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
179,
190
]
} |
sodium saccharin alone induced a transient hyperplastic response of the cultured urothelium but did not induce significantly more foci than in controls , though a late toxic effect of saccharin may have masked focus induction . | NA | {
"id": "C0917900",
"name": "sodium saccharin",
"pos": [
0,
16
]
} | {
"id": "C0036023",
"name": "saccharin",
"pos": [
184,
193
]
} |
in combination with a single dose of 250 micrograms/ml mnu , sodium saccharin did not increase focus incidence compared with mnu treatment alone but following a single treatment with 25 micrograms/ml mnu which alone induced no foci , saccharin induced a significant number of foci indicating a promoting effect under the... | NA | {
"id": "C0917900",
"name": "sodium saccharin",
"pos": [
61,
77
]
} | {
"id": "C0036023",
"name": "saccharin",
"pos": [
234,
243
]
} |
the cross-sectional relationship of endogenous androgens ( testosterone , androstenedione , and dehydroepiandrosterone sulfate [ dhea-s ] ) , estrogen ( estradiol ) and progestin ( progesterone ) to serum levels of lipoprotein cholesterol ( very low-density [ vldl ] , low-density [ ldl ] , and high-density lipoprotein ... | NA | {
"id": "C0003591",
"name": "apolipoproteins",
"pos": [
334,
349
]
} | {
"id": "C0003593",
"name": "apo b",
"pos": [
364,
369
]
} |
this information can serve as a baseline for the evaluation of animal preparations of tachycardia and , when combined with knowledge of the location of the arrhythmogenic region furnished by intraoperative mapping , should lead to better understanding of the anatomic substrate for ventricular tachycardia . | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
86,
97
]
} | {
"id": "C0042514",
"name": "ventricular tachycardia",
"pos": [
282,
305
]
} |
these results indicate that endocardial catheter mapping combined with wire skeleton representation of computed positions of arrhythmogenic sites is reliable for guiding surgical therapy of ventricular tachycardia and since some of the ventricular tachycardias were inducible only during either preoperative or intraoper... | NA | {
"id": "C0039231",
"name": "tachycardia",
"pos": [
202,
213
]
} | {
"id": "C0042514",
"name": "ventricular tachycardias",
"pos": [
236,
260
]
} |
furthermore , analysis of the relationship between infarct size and collateral flow measured during ischemia in the two groups indicated that protection by h-sod was greatest in animals with the lowest collateral flows . | NA | {
"id": "C0021308",
"name": "infarct",
"pos": [
51,
58
]
} | {
"id": "C0022116",
"name": "ischemia",
"pos": [
100,
108
]
} |
the conference panel on special situations recommended that : the heimlich maneuver should only be performed on near-drowning victims when the rescuer suspects that foreign matter is obstructing the airway or the victim fails to respond appropriately to mouth-to-mouth ventilation , further investigation is needed to be... | NA | {
"id": "C0013142",
"name": "drowning",
"pos": [
117,
125
]
} | {
"id": "C0027516",
"name": "near-drowning",
"pos": [
400,
413
]
} |
several conditions that contribute to drowning and near drowning must be considered in the treatment of near-drowned victims . | NA | {
"id": "C0013142",
"name": "drowning",
"pos": [
38,
46
]
} | {
"id": "C0027516",
"name": "near drowning",
"pos": [
51,
64
]
} |
peripheral blood mononuclear cells were incubated with con a and then suppression of proliferation was measured by coculture of these cells with healthy volunteers ' mononuclear cells and phytohaemagglutinin . | NA | {
"id": "C1321301",
"name": "peripheral blood",
"pos": [
0,
16
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
178,
183
]
} |
antibodies of igg and iga isotypes were determined with elisa and those of ige isotype with rast . | NA | {
"id": "C0020852",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0021017",
"name": "isotype",
"pos": [
79,
86
]
} |
specific igg antibodies to micropolyspora faeni , thermoactinomyces vulgaris , aspergillus umbrosus and aspergillus fumigatus were measured by elisa from the serum samples obtained in the two surveys . | NA | {
"id": "C0004034",
"name": "aspergillus",
"pos": [
79,
90
]
} | {
"id": "C0004037",
"name": "aspergillus fumigatus",
"pos": [
104,
125
]
} |
simultaneous liquid-chromatographic determination of 3,4-dihydroxyphenylglycol , catecholamines , and 3,4-dihydroxyphenylalanine in plasma , and their responses to inhibition of monoamine oxidase . | NA | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
81,
95
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
106,
128
]
} |
this is a reversed-phase liquid-chromatographic method , with electrochemical detection , for simultaneously measuring , in plasma , the concentrations of the catecholamine precursor dihydroxyphenylalanine ( dopa ) ; | NA | {
"id": "C0007412",
"name": "catecholamine",
"pos": [
159,
172
]
} | {
"id": "C0013023",
"name": "dihydroxyphenylalanine",
"pos": [
183,
205
]
} |
inhibition of monoamine oxidase ( by administering deprenyl or tranylcypromine ) decreased plasma dhpg by greater than 65 % , plasma dopac by greater than 50 % , and plasma dopa by about 20 % , without consistently affecting norepinephrine or epinephrine . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
225,
239
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
243,
254
]
} |
simultaneous measurement of dopa , catecholamines , and dhpg may be useful for examining the synthesis , release , and intraneuronal metabolism of norepinephrine . | NA | {
"id": "C0013023",
"name": "dopa",
"pos": [
28,
32
]
} | {
"id": "C0007412",
"name": "catecholamines",
"pos": [
35,
49
]
} |
we suspect that a virus-induced decrease in clearance of the enzyme from serum is responsible for a similar increase of bone and liver isoenzyme activities and for the presence of these fragmented isoenzymes in transient hyperphosphatasemia . | NA | {
"id": "C0014442",
"name": "enzyme",
"pos": [
61,
67
]
} | {
"id": "C0022173",
"name": "isoenzymes",
"pos": [
197,
207
]
} |
these heterophilic antibodies complexed with the ovine antisera to human thyrotropin that are used in the ria system , in particular blocking the binding of tsh but also partly blocking interaction with the second antibody . | NA | {
"id": "C0003248",
"name": "heterophilic antibodies",
"pos": [
6,
29
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
214,
222
]
} |
these heterophilic antibodies complexed with the ovine antisera to human thyrotropin that are used in the ria system , in particular blocking the binding of tsh but also partly blocking interaction with the second antibody . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
55,
63
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
214,
222
]
} |
this paper illustrates several important points relating to the use of allopurinol in renal failure , or situations of purine overproduction : it is very easy to give too much allopurinol . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
119,
125
]
} | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
176,
187
]
} |
patients with hgprt deficiency are exquisitely sensitive to allopurinol , and careful monitoring of the effect on urinary purine levels is essential if xanthine colic is to be avoided . | NA | {
"id": "C0002144",
"name": "allopurinol",
"pos": [
60,
71
]
} | {
"id": "C0034140",
"name": "purine",
"pos": [
122,
128
]
} |
the word trismus , from the greek 'trismos ' , is defined as a prolonged , tetanic spasm of the jaw muscles by which the normal opening of the mouth is restricted ( locked jaw ) . | NA | {
"id": "C0041105",
"name": "trismus",
"pos": [
9,
16
]
} | {
"id": "C0037763",
"name": "spasm of",
"pos": [
83,
91
]
} |
other diabetic complications develop as diabetic nephropathy progresses , most notably cardiac and peripheral vascular disease . | NA | {
"id": "C0342257",
"name": "diabetic complications",
"pos": [
6,
28
]
} | {
"id": "C0011881",
"name": "diabetic nephropathy",
"pos": [
40,
60
]
} |
the effect of various exogenous cells on the in-vitro pwm stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated . | NA | {
"id": "C0007634",
"name": "the",
"pos": [
0,
3
]
} | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
114,
148
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.