text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in vivo , adrenaline and noradrenaline evoked pressor effects which were of shorter duration and smaller magnitude in hormone-treated animals than in the controls . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
10,
20
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
25,
38
]
} |
furthermore , a subsequent fall in blood pressure to below normal was observed , not only with adrenaline but also with noradrenaline , in animals receiving thyroid hormones . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
95,
105
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
120,
133
]
} |
these changes might represent adaptative mechanisms in hyperthyroid states , and might depend on a greater sensitivity of endothelial beta 2-receptors to noradrenaline and adrenaline . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
154,
167
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
172,
182
]
} |
norepinephrine , epinephrine , alpha-methylnorepinephrine and 6-fluoronorepinephrine were full agonists , while methoxamine and phenylephrine were partial agonists in both systems . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
73,
84
]
} |
norepinephrine , epinephrine , alpha-methylnorepinephrine and 6-fluoronorepinephrine were full agonists , while methoxamine and phenylephrine were partial agonists in both systems . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
0,
14
]
} | {
"id": "C0025805",
"name": "alpha-methylnorepinephrine",
"pos": [
31,
57
]
} |
the dopac/dopamine and hva/dopamine ratios in extracted whole tissue were determined to obtain an index of dopaminergic activity in various rat brain regions 24 h following 10 days ' treatment with haloperidol ( 0.5 and 2 mg/kg ) or sulpiride ( 10 and 100 mg/kg ) . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
10,
18
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
107,
119
]
} |
this pg release was inhibited by acetylsalicylic acid ( 10 ( -5 ) - 10 ( -6 ) mol/l ) and indomethacin ( 10 ( -6 ) - 10 ( -9 ) mol/l ) but also by high concentrations ( 10 ( -3 ) - 10 ( -5 ) mol/l ) of the non-acid compounds 4-methyl-aminophenazone , the main active metabolite of dipyrone ( metamizol ) , and acetaminop... | NA | {
"id": "C0002586",
"name": "aminophenazone",
"pos": [
234,
248
]
} | {
"id": "C0012586",
"name": "metamizol",
"pos": [
292,
301
]
} |
the effect of tolazamide ( tz ) , a sulfonylurea , on 14c-2-deoxyglucose ( 14c-2dg ) tissue distribution and insulin levels of normal and obese mice was investigated using an in vivo physiological method . | NA | {
"id": "C0040372",
"name": "tolazamide",
"pos": [
14,
24
]
} | {
"id": "C0038766",
"name": "sulfonylurea",
"pos": [
36,
48
]
} |
a reversible equilibrium exists between beta h ( igh ) -crystallins ( predominantly hexamers ) and a portion of the beta l ( ow ) -crystallins ( predominantly dimers ) . | NA | {
"id": "C0005203",
"name": "beta",
"pos": [
40,
44
]
} | {
"id": "C0010422",
"name": "crystallins",
"pos": [
131,
142
]
} |
the results suggest the presence of sialic acid and galactose as the constituent carbohydrates of glycoconjugates in the interphotoreceptor matrices and rpe microvilli . | NA | {
"id": "C0007004",
"name": "carbohydrates",
"pos": [
81,
94
]
} | {
"id": "C0017906",
"name": "glycoconjugates",
"pos": [
98,
113
]
} |
total outflow facility was measured by two-level constant pressure anterior chamber perfusion in surgically untouched and totally iridectomized cynomolgus monkey eyes receiving bolus intracameral infusions of cyclic amp , dibutyryl cyclic amp , or 5'amp . | NA | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
209,
219
]
} | {
"id": "C0012054",
"name": "dibutyryl",
"pos": [
222,
231
]
} |
however , when bm cells are treated with lps and the tumor-promoting phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) simultaneously , they generate significant levels of csf . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
69,
82
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl-phorbol-13-acetate",
"pos": [
83,
120
]
} |
lipid a is as effective as lps in stimulating bm cells in the presence of tpa , but other mitogens , such as phytohemagglutinin ( pha ) , concanavalin a ( con a ) , or pokeweed mitogen ( pwm ) , are ineffective . | NA | {
"id": "C0023767",
"name": "lipid a",
"pos": [
0,
7
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
27,
30
]
} |
in a graphic presentation we tried to give a synopsis of morphological and clinical entities under the three morphologic notions bronchiolitis , alveolitis and bronchitis and emphysema . | NA | {
"id": "C0006271",
"name": "bronchiolitis",
"pos": [
129,
142
]
} | {
"id": "C0006277",
"name": "bronchitis",
"pos": [
160,
170
]
} |
penfield proposed that the meningocerebral scar that forms following trauma to the brain plays an important role in the development of posttraumatic epilepsy . | NA | {
"id": "C0270611",
"name": "trauma",
"pos": [
69,
75
]
} | {
"id": "C0014557",
"name": "posttraumatic epilepsy",
"pos": [
135,
157
]
} |
although effective when given prophylactically , prednisolone did not inhibit the activity of an already established epileptic focus whether induced by aluminum or by amygdala kindling , nor did it block pentylenetetrazol-induced seizures . | NA | {
"id": "C0014544",
"name": "epileptic",
"pos": [
117,
126
]
} | {
"id": "C0036572",
"name": "seizures",
"pos": [
230,
238
]
} |
baclofen is an analog of the inhibitory neurotransmitter , gaba , which is used clinically to control spasticity . | NA | {
"id": "C0004609",
"name": "baclofen",
"pos": [
0,
8
]
} | {
"id": "C0016904",
"name": "gaba",
"pos": [
59,
63
]
} |
the excitatory responses of identified and unidentified lateral hypothalamic area neurons to angiotensin ii were blocked by microiontophoretically applied saralasin , an angiotensin ii antagonist . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
155,
164
]
} | {
"id": "C0003009",
"name": "angiotensin ii",
"pos": [
170,
184
]
} |
at day 5 of infection , parasites were almost exclusively in reticulocytes in contrast to control infections in which parasites were found in oxyphilic erythrocytes at day 5 after infection . | NA | {
"id": "C0030499",
"name": "infections",
"pos": [
98,
108
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
180,
189
]
} |
parasitized reticulocytes were more readily opsonized by antibodies from immune serum when compared to parasitized oxyphilic red blood cells and when used to stimulate immune spleen cells the former were better stimulator cells than the latter . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
57,
67
]
} | {
"id": "C0020960",
"name": "immune serum",
"pos": [
73,
85
]
} |
two peptides which showed the same retention time as kallidin and bradykinin in a reverse phase high pressure liquid chromatography system were detected in cerebrospinal fluid of rats . | NA | {
"id": "C0022474",
"name": "kallidin",
"pos": [
53,
61
]
} | {
"id": "C0006100",
"name": "bradykinin",
"pos": [
66,
76
]
} |
antimicrobial and antifungal activity of some of the described compounds was tested in a preliminary screening . | NA | {
"id": "C1136254",
"name": "antimicrobial",
"pos": [
0,
13
]
} | {
"id": "C0003308",
"name": "antifungal",
"pos": [
18,
28
]
} |
a brief heating ( 3 min at 57 degrees c ) , which did not affect control subunit activity , enhanced protein synthesis inhibition of the toxin-treated subunits that released more 5 s rna , in the form of nucleoprotein complex ( es ) with protein l5 and phosphoproteins p1p2 ( rnph ) , than did heated control subunits [ ... | NA | {
"id": "C0028612",
"name": "nucleoprotein",
"pos": [
204,
217
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
260,
267
]
} |
a brief heating ( 3 min at 57 degrees c ) , which did not affect control subunit activity , enhanced protein synthesis inhibition of the toxin-treated subunits that released more 5 s rna , in the form of nucleoprotein complex ( es ) with protein l5 and phosphoproteins p1p2 ( rnph ) , than did heated control subunits [ ... | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
101,
108
]
} | {
"id": "C0031689",
"name": "phosphoproteins",
"pos": [
253,
268
]
} |
the presence of a cooh-terminal extension to the b-chain is consistent with the occurrence of a single base mutation in the region of the gene encoding one of the dibasic residue processing sites [ arg31 ( aga ) -- -- ile* ( aua ) ] with the result that the ratfish has utilised an alternative cleavage site within the c... | NA | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
319,
328
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
339,
349
]
} |
treatment of intact hepatocytes with the phorbol ester 12-o-tetradecanoyl phorbol 13-acetate ( tpa ) potentiated the ability of glucagon to increase intracellular cyclic amp concentrations . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
41,
54
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoyl",
"pos": [
55,
73
]
} |
advances in the study of cholinesterase biology have been facilitated by the development of polyclonal and monoclonal antibodies to acetylcholinesterase ( ache ) ( ec 3.1.1.7 ) and butyrylcholinesterase ( buche ) ( ec 3.1.1.8 ) in several laboratories . | NA | {
"id": "C0001044",
"name": "acetylcholinesterase",
"pos": [
132,
152
]
} | {
"id": "C0008429",
"name": "butyrylcholinesterase",
"pos": [
181,
202
]
} |
several applications are described , including an analysis of buche phylogeny within the higher primates , an immunodisplacement assay of ache in normal human red blood cells and cells from patients with paroxysmal nocturnal hemoglobinuria , a study of immunochemical differences between membrane-associated and soluble ... | NA | {
"id": "C0008429",
"name": "buche",
"pos": [
62,
67
]
} | {
"id": "C0001044",
"name": "ache",
"pos": [
320,
324
]
} |
similarities in this membrane-binding structure to those reported for trypanosome variant surface glycoproteins and thy-1 glycoprotein suggest an important new category of posttranslational modifications involving the attachment of cooh-terminal glycolipid . | NA | {
"id": "C0025248",
"name": "surface glycoproteins",
"pos": [
90,
111
]
} | {
"id": "C0017968",
"name": "glycoprotein",
"pos": [
122,
134
]
} |
during the 6-month study period , no differences were found in fasting plasma glucose , 24-hour insulin requirements , glycated hemoglobin , free fatty acids , low-density lipoprotein cholesterol concentrations , or high-density lipoprotein cholesterol/total cholesterol ratio between the patients in each treatment grou... | NA | {
"id": "C0023824",
"name": "low-density lipoprotein cholesterol",
"pos": [
160,
195
]
} | {
"id": "C0008377",
"name": "cholesterol",
"pos": [
259,
270
]
} |
the hcg injection given to the patients 36 hours before laparoscopy caused partial desensitization of adenylate cyclase of these cells to gonadotropins . | NA | {
"id": "C0018062",
"name": "hcg",
"pos": [
4,
7
]
} | {
"id": "C0018061",
"name": "gonadotropins",
"pos": [
138,
151
]
} |
in all dp and the normal subjects , plasma concentration of aldosterone ( pald ) , 18-hydroxycorticosterone ( p18-oh-b ) , corticosterone ( pb ) , 11-deoxycorticosterone ( pdoc ) and cortisol ( pf ) were measured before and after intravenous administration of angiotensin ii ( aii , 10 ng/kg/min , for 30 min ) or acth (... | NA | {
"id": "C0000172",
"name": "18-hydroxycorticosterone",
"pos": [
83,
107
]
} | {
"id": "C0010124",
"name": "corticosterone",
"pos": [
155,
169
]
} |
to clarify the precise mechanism by which unrelated peptides , cholecystokinin or carbamylcholine , modulate the somatostatin binding , the effect of a phorbol ester , 12-o-tetradecanoylphorbol-13-acetate ( tpa ) or a synthetic diacylglycerol analog , 1-oleyl-2-acetylglycerol ( oag ) on [ 125i-tyr1 ] somatostatin bindi... | NA | {
"id": "C0031586",
"name": "phorbol",
"pos": [
152,
159
]
} | {
"id": "C0039654",
"name": "12-o-tetradecanoylphorbol-13-acetate",
"pos": [
168,
204
]
} |
plasma lh , fsh and endogenous lhrh were determined by radioimmunoassay ( ria ) when 100 micrograms of lhrh superanalogue , des-gly10- [ d-leu6 ] -lhrh ethylamide ( leuprolide ) was intranasally administered to both 7 healthy subjects aged 22 to 63 years and 6 patients with various hypogonadism aged 22 to 43 years [ 2 ... | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
31,
35
]
} | {
"id": "C0085272",
"name": "leuprolide",
"pos": [
165,
175
]
} |
the elevation of plasma immunoreactive lhrh which was determined using ria having no immunocrossreactivity with leuprolide ( less than 0.01 % ) was observed at 6 hours after the administration of leuprolide in the healthy subjects ( 789 +/- 497 % ) . | NA | {
"id": "C0023610",
"name": "lhrh",
"pos": [
39,
43
]
} | {
"id": "C0085272",
"name": "leuprolide",
"pos": [
196,
206
]
} |
the plasma concentrations of pregnenolone ( 1449 ng/dl ) , progesterone ( 178 ng/dl ) , 17-oh-pregnenolone ( 1613 ng/dl ) , 17-oh-progesterone ( 180 ng/dl ) , dehydroepiandrosterone ( 3706 ng/dl ) , androstendione ( 824.6 ng/dl ) and testosterone ( 900 ng/dl ) were high , whereas deoxycorticosterone ( 15.7 ng/dl ) , co... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
29,
41
]
} | {
"id": "C0376260",
"name": "17-oh-pregnenolone",
"pos": [
88,
106
]
} |
the plasma concentrations of pregnenolone ( 1449 ng/dl ) , progesterone ( 178 ng/dl ) , 17-oh-pregnenolone ( 1613 ng/dl ) , 17-oh-progesterone ( 180 ng/dl ) , dehydroepiandrosterone ( 3706 ng/dl ) , androstendione ( 824.6 ng/dl ) and testosterone ( 900 ng/dl ) were high , whereas deoxycorticosterone ( 15.7 ng/dl ) , co... | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
59,
71
]
} | {
"id": "C0020387",
"name": "17-oh-progesterone",
"pos": [
124,
142
]
} |
after 4-7 days culture , these cells were transformed into fibroblast-like cells with a gradual depletion of lipid droplets and with abundant well-developed rough endoplasmic reticulum . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
31,
36
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
59,
69
]
} |
one peripherally located cell type is sparsely granulated and appears to be a precursor cell . | NA | {
"id": "C0007634",
"name": "cell type",
"pos": [
25,
34
]
} | {
"id": "C0018956",
"name": "precursor cell",
"pos": [
78,
92
]
} |
analysis of another thyroid membrane protein , human thyroid microsomal antigen ( mr = 110,000 by sds-page ) under the same conditions gave an s20 , w of 6.0 s and f/f0 = 1.3 , suggesting that this protein has a compact structure . | NA | {
"id": "C0025252",
"name": "membrane",
"pos": [
28,
36
]
} | {
"id": "C0033684",
"name": "protein",
"pos": [
198,
205
]
} |
the observed order of potency of adrenergic agonists ( kd values ) in competing for [ 125i ] cyp binding was : ( - ) isoproterenol ( 25 nm ) greater than ( - ) epinephrine ( 74 nm ) much greater than ( - ) norepinephrine ( 1900 nm ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
160,
171
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
206,
220
]
} |
since some 25 % of chloride absorption is coupled with bicarbonate secretion by an anion exchange mechanism , the impairment in chloride absorption should be accompanied by modifications in bicarbonate secretion . | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
83,
88
]
} | {
"id": "C0008203",
"name": "chloride",
"pos": [
128,
136
]
} |
the nonselective cck/gastrin antagonist , proglumide , but not the selective cck antagonist , asperlicin , antagonized the acid response to both pentagastrin and cck-8 . | NA | {
"id": "C0017151",
"name": "gastrin",
"pos": [
21,
28
]
} | {
"id": "C0030859",
"name": "pentagastrin",
"pos": [
145,
157
]
} |
these antibodies could be divided into two classes , and we present the results obtained with one representative antibody of each class . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
6,
16
]
} | {
"id": "C0021017",
"name": "antibody",
"pos": [
113,
121
]
} |
ang ii rapidly increased ne concentration in the arterial plasma of adult ducks , while avt increased epinephrine ( e ) concentration . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
25,
27
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
102,
113
]
} |
at a relatively high concentration ( 1.0 microgram/ml ) , a number of different steroids , including pregnenolone , 17 alpha-hydroxypregnenolone , corticosterone , cortisol , 11-deoxycorticosterone , 11-deoxycortisol , androstenedione , testosterone , progesterone , 17 alpha-hydroxyprogesterone , 20 beta-dihydroprogest... | NA | {
"id": "C0373704",
"name": "pregnenolone",
"pos": [
101,
113
]
} | {
"id": "C0376260",
"name": "17 alpha-hydroxypregnenolone",
"pos": [
116,
144
]
} |
the exg sequence is preceded by a putative signal peptide of 41 aa , a translational initiation codon , and a sequence resembling a ribosome-binding site five nucleotides ( nt ) before the initiation codon . | NA | {
"id": "C0009221",
"name": "codon",
"pos": [
96,
101
]
} | {
"id": "C0242610",
"name": "initiation codon",
"pos": [
189,
205
]
} |
about 15 % of the input ss dna template molecules are converted into ds dna fragments . | NA | {
"id": "C0012935",
"name": "ss dna",
"pos": [
24,
30
]
} | {
"id": "C0012854",
"name": "ds dna",
"pos": [
69,
75
]
} |
because of its high degree of species specificity and its heterodisperse distribution , this sequence provided a useful marker for rat dna in dna transfection experiments into mouse host cells . | NA | {
"id": "C0000702",
"name": "a",
"pos": [
3,
4
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
142,
145
]
} |
moreover , this sign was also found in seven of eight patients with non cirrhotic portal hypertension , but was seen neither in 100 patients with chronic alcoholism but without liver disease , nor in 10 cirrhotic patients with end-to-side portacaval shunts . | NA | {
"id": "C0020541",
"name": "portal hypertension",
"pos": [
82,
101
]
} | {
"id": "C0023895",
"name": "liver disease",
"pos": [
177,
190
]
} |
fetal weights showed a different pattern , there was a significant difference between the unsupplemented zinc-deficient group b and the other two groups which led us to think that the daily food consumption of groups b and c , even though enough to produce lower weight in the dams , was not sufficiently low to produce ... | NA | {
"id": "C0751992",
"name": "fetal weights",
"pos": [
0,
13
]
} | {
"id": "C0005910",
"name": "weight",
"pos": [
441,
447
]
} |
quantitation was performed with a recently developed lectin-mediated light scattering ( nephelometry ) method after separation of soluble proteins from the mucin . | NA | {
"id": "C0023206",
"name": "lectin",
"pos": [
53,
59
]
} | {
"id": "C0033684",
"name": "proteins",
"pos": [
138,
146
]
} |
inhibition of vitamin-k-dependent carboxylation versus antagonist concentration was determined for 2,3,5,6-tetrachloropyridin-4-ol ( tcp ) , phenindione , 2,6-dichloroindophenol sodium ( 2,6-dip ) , 2-chloro-1,4-naphthoquinone ( chloro-k3 ) , 2-chloro-3-phytyl-1,4-naphthoquinone ( chloro-k1 ) and warfarin . | NA | {
"id": "C0042878",
"name": "vitamin-k",
"pos": [
14,
23
]
} | {
"id": "C0027388",
"name": "naphthoquinone",
"pos": [
265,
279
]
} |
the potential thyrotoxic effect of sk & f 93479 ( an h2-receptor antagonist ) , aminoglutethimide ( ag ) and glutethimide were studied by examining their effects on 125iodide uptake and organification ( incorporation into thyroglobulin ) in cultured thyroid cells from the pig and rat . | NA | {
"id": "C0002555",
"name": "aminoglutethimide",
"pos": [
80,
97
]
} | {
"id": "C0017845",
"name": "glutethimide",
"pos": [
109,
121
]
} |
pathobiological endpoints used in these studies include alterations in incorporation rates of precursors into dna , rna and protein , in the clonal growth rate of cultured cells and in dna structure ( e.g . single-strand breaks , dna-protein crosslinks and chemical-dna adducts ) and the induction of differentiation , c... | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
110,
113
]
} | {
"id": "C0242958",
"name": "dna adducts",
"pos": [
266,
277
]
} |
this difference is probably due to oxidation of the enzymes involved in the conversion of methionine to cysteine , whereas n-acetylcysteine can still serve as a precursor of glutathione . | NA | {
"id": "C0010654",
"name": "cysteine",
"pos": [
104,
112
]
} | {
"id": "C0001047",
"name": "n-acetylcysteine",
"pos": [
123,
139
]
} |
polyhydroxylated flavonoids with a c2-c3 double bond ( flavones and flavonols ) were more effective inhibitors of the enzyme in both hepatic and intestinal microsomes than were the reduced homologues ( flavanonols , flavanones and flavan-3-ols ) . | NA | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
17,
27
]
} | {
"id": "C0016219",
"name": "flavones",
"pos": [
55,
63
]
} |
polyhydroxylated flavonoids with a c2-c3 double bond ( flavones and flavonols ) were more effective inhibitors of the enzyme in both hepatic and intestinal microsomes than were the reduced homologues ( flavanonols , flavanones and flavan-3-ols ) . | NA | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
17,
27
]
} | {
"id": "C0060444",
"name": "flavonols",
"pos": [
68,
77
]
} |
polyhydroxylated flavonoids with a c2-c3 double bond ( flavones and flavonols ) were more effective inhibitors of the enzyme in both hepatic and intestinal microsomes than were the reduced homologues ( flavanonols , flavanones and flavan-3-ols ) . | NA | {
"id": "C0596577",
"name": "flavonoids",
"pos": [
17,
27
]
} | {
"id": "C1257969",
"name": "flavanones",
"pos": [
216,
226
]
} |
levels of serum glutamic-oxalacetic transaminase ( sgot ) , glutamic-pyruvic transaminase ( sgpt ) , isocitrate dehydrogenase and ornithine-carbamyl transferase , bile flow and biliary excretion of an anionic model compound , phenolphthalein glucuronide ( pg ) , were measured on day 16 . | NA | {
"id": "C0002594",
"name": "transaminase",
"pos": [
36,
48
]
} | {
"id": "C0001899",
"name": "glutamic-pyruvic transaminase",
"pos": [
60,
89
]
} |
the elimination kinetics of organochlorine compounds ( dde , lindane , aldrin , heptachlor epoxide and heptachlor ) from day 2 to day 10 of breast feeding was studied in 39 volunteers who had a baby in the maternity department in nancy . | NA | {
"id": "C0020247",
"name": "organochlorine compounds",
"pos": [
28,
52
]
} | {
"id": "C0011038",
"name": "dde",
"pos": [
55,
58
]
} |
the elimination kinetics of organochlorine compounds ( dde , lindane , aldrin , heptachlor epoxide and heptachlor ) from day 2 to day 10 of breast feeding was studied in 39 volunteers who had a baby in the maternity department in nancy . | NA | {
"id": "C0020247",
"name": "organochlorine compounds",
"pos": [
28,
52
]
} | {
"id": "C0005038",
"name": "lindane",
"pos": [
61,
68
]
} |
the elimination kinetics of organochlorine compounds ( dde , lindane , aldrin , heptachlor epoxide and heptachlor ) from day 2 to day 10 of breast feeding was studied in 39 volunteers who had a baby in the maternity department in nancy . | NA | {
"id": "C0020247",
"name": "organochlorine compounds",
"pos": [
28,
52
]
} | {
"id": "C0002011",
"name": "aldrin",
"pos": [
71,
77
]
} |
the elimination kinetics of organochlorine compounds ( dde , lindane , aldrin , heptachlor epoxide and heptachlor ) from day 2 to day 10 of breast feeding was studied in 39 volunteers who had a baby in the maternity department in nancy . | NA | {
"id": "C0020247",
"name": "organochlorine compounds",
"pos": [
28,
52
]
} | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
103,
113
]
} |
the elimination kinetics of organochlorine compounds ( dde , lindane , aldrin , heptachlor epoxide and heptachlor ) from day 2 to day 10 of breast feeding was studied in 39 volunteers who had a baby in the maternity department in nancy . | NA | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
80,
98
]
} | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
103,
113
]
} |
on day 2 , contamination with lindane , aldrin , heptachlor epoxide and heptachlor averaged 43.8 , 23.5 , 25.4 and 7.4 ng/g fat , respectively , and the levels showed a linear decrease on subsequent days in all cases except that of heptachlor , for which no significant negative correlation with time could be demonstrat... | NA | {
"id": "C0019220",
"name": "heptachlor epoxide",
"pos": [
49,
67
]
} | {
"id": "C0019219",
"name": "heptachlor",
"pos": [
232,
242
]
} |
the micronucleus test using mouse bone-marrow polychromatic erythrocytes was used to study the extent to which benzo [ a ] pyrene ( bp ) mutagenicity was inhibited by mixtures of simple phenols ( resorcinol and pyrogallol ) with and without the complex hindered-phenol antioxidant dibunol ( 2,6-di-tert-butyl-4-methylphe... | NA | {
"id": "C0035197",
"name": "resorcinol",
"pos": [
196,
206
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
317,
323
]
} |
the micronucleus test using mouse bone-marrow polychromatic erythrocytes was used to study the extent to which benzo [ a ] pyrene ( bp ) mutagenicity was inhibited by mixtures of simple phenols ( resorcinol and pyrogallol ) with and without the complex hindered-phenol antioxidant dibunol ( 2,6-di-tert-butyl-4-methylphe... | NA | {
"id": "C0034303",
"name": "pyrogallol",
"pos": [
211,
221
]
} | {
"id": "C0031428",
"name": "phenol",
"pos": [
317,
323
]
} |
diet-induced changes in monooxygenase activities were found to be the best indicators of changes in microsome-mediated bp mutagenesis and afb1 mutagenesis and binding to dna in vitro , with a direct correlation between high ahh and/or ecd activities and the levels of mutagenic response to bp or afb1 in the ames assay a... | NA | {
"id": "C0003927",
"name": "ahh",
"pos": [
224,
227
]
} | {
"id": "C0000644",
"name": "ecd",
"pos": [
235,
238
]
} |
following single iv doses of 10 or 50 mg [ 14c ] dcm/kg dose-dependent metabolism to 14co2 and 14co and rapid pulmonary clearance of unchanged 14ch2cl2 characterized the elimination of dcm from the body . | NA | {
"id": "C0025519",
"name": "metabolism",
"pos": [
71,
81
]
} | {
"id": "C0221102",
"name": "elimination",
"pos": [
170,
181
]
} |
[ experiences with human insulin . results of a study in 1,267 diabetics previously treated with animal insulin ] . | NA | {
"id": "C0795635",
"name": "human insulin",
"pos": [
19,
32
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
104,
111
]
} |
one is the public epitope among dqw3 antigens , and the other is the private epitope that hu-23 recognizes . | NA | {
"id": "C0003320",
"name": "antigens",
"pos": [
37,
45
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
77,
84
]
} |
during immersion suppression of plasma noradrenaline and adrenaline was observed but no change occurred in plasma dopamine levels . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
39,
52
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
57,
67
]
} |
the predominant iri peak comigrated with marker insulin ( 95.7 +/- 0.8 % ) , another prominent peak occurred coincident with proinsulin standard ( 3.3 +/- 0.5 % ) , a third peak was present in the void volume ( 0.28 +/- 0.04 % ) . | NA | {
"id": "C0021641",
"name": "insulin",
"pos": [
48,
55
]
} | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
125,
135
]
} |
eighteen phaeochromocytomas , including both sporadic and familial cases , four cervical paragangliomas , two jugular paragangliomas , and one abdominal paraganglioma were examined immunohistochemically for the presence of s-100 protein . | NA | {
"id": "C0031511",
"name": "phaeochromocytomas",
"pos": [
9,
27
]
} | {
"id": "C0030421",
"name": "paraganglioma",
"pos": [
153,
166
]
} |
positive staining in cells morphologically similar to the sustentacular cells of normal paraganglia and adrenal medulla were found in all paragangliomas and in the benign and aggressively growing phaeochromocytomas . | NA | {
"id": "C0030421",
"name": "paragangliomas",
"pos": [
138,
152
]
} | {
"id": "C0031511",
"name": "phaeochromocytomas",
"pos": [
196,
214
]
} |
eda ( ectodermal dysplasia , anhidrotic ) is an x-linked recessive disorder characterized by hypohidrosis , hypoor anodontia , and hypotrichosis . | NA | {
"id": "C0162359",
"name": "eda",
"pos": [
0,
3
]
} | {
"id": "C0013575",
"name": "ectodermal dysplasia",
"pos": [
6,
26
]
} |
b lineage cells in the bone marrow are dynamically heterogeneous : a large majority are newly-formed , rapidly renewed cells , continuously produced from precursor cells within the bone marrow and disseminated during a terminal maturation phase via the blood stream . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C0018956",
"name": "precursor cells",
"pos": [
154,
169
]
} |
clones recognizing epitopes associated with one of the priming antigens and also with another unrelated d-region specificity . | NA | {
"id": "C0003316",
"name": "epitopes",
"pos": [
19,
27
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
63,
71
]
} |
an enzyme-linked immunosorbent assay performed with target cell membranes that were treated with streptolysin o in the presence and absence of neutralizing antibodies showed that the antibodies did not block primary binding of the toxin to the cells . | NA | {
"id": "C0475463",
"name": "neutralizing",
"pos": [
143,
155
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
183,
193
]
} |
these results show that the serum resistance of 144m-sr does not represent a failure to activate complement efficiently , but instead reflects failure of the assembled terminal complement complex c5b-9 to insert stably into the outer membrane of this strain . | NA | {
"id": "C0009498",
"name": "complement",
"pos": [
97,
107
]
} | {
"id": "C0009545",
"name": "complement complex c5b-9",
"pos": [
177,
201
]
} |
using an enzyme-linked immunoassay with isotype-specific conjugates , we found that antibody of all four subclasses of igg were evoked during the course of the immune responses of c3h/heau mice to b. abortus endotoxin . | NA | {
"id": "C0021017",
"name": "isotype",
"pos": [
40,
47
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
84,
92
]
} |
the effects of lipopolysaccharide ( lps ) -associated protein on the immunogenic properties of b. abortus endotoxin were examined by comparing responses to endotoxin with those to a purified b. abortus lps containing less than 1 % protein . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
15,
33
]
} | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
156,
165
]
} |
the endotoxin evoked strong primary and secondary responses in which antibody directed to lps determinants consisted mainly of igg3 and those to the protein determinants were largely igg1 antibody . | NA | {
"id": "C0014264",
"name": "endotoxin",
"pos": [
4,
13
]
} | {
"id": "C0023810",
"name": "lps",
"pos": [
90,
93
]
} |
because of the problem of charcoal in releasing emboli and depleting platelets we first developed coated activated charcoal hemoperfusion for clinical application . | NA | {
"id": "C0007955",
"name": "charcoal",
"pos": [
26,
34
]
} | {
"id": "C0001275",
"name": "activated charcoal",
"pos": [
105,
123
]
} |
in a prospectively randomised study the influence of 4 ml lidocaine 2 % plain or with epinephrine 1:100,000 or norepinephrine 1:20,000 on heart rate and blood pressure before , during and after a small surgical intervention ( tooth extraction ) was investigated in a normotensive ( n = 39 ) and a hypertensive group ( n ... | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
86,
97
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
111,
125
]
} |
the bioavailability of cloxacillin and flucloxacillin were compared after the oral administration , in capsule form , of 500 mg cloxacillin or 250 mg flucloxacillin to healthy volunteers . | NA | {
"id": "C0016267",
"name": "flucloxacillin",
"pos": [
39,
53
]
} | {
"id": "C0009077",
"name": "cloxacillin",
"pos": [
153,
164
]
} |
minocycline + gentamicin appeared at least as effective than metronidazole + gentamicin in preventing postoperative infectious complications associated with abdominal surgery or in treating intra-abdominal infections . | NA | {
"id": "C0009450",
"name": "infectious",
"pos": [
116,
126
]
} | {
"id": "C1112209",
"name": "intra-abdominal",
"pos": [
190,
205
]
} |
the effects of clofazamine ( 3- ( p-chloroanilino ) -10- ( p-chlorophenyl ) -2 , 10-dihydro-2- ( isopropylimino ) -phenazine ) at concentrations of 0.625-20 micrograms/ml on the mitogen-induced transformation , luminol-enhanced chemiluminescence , arachidonic acid metabolism and sulphydryl content of human mononuclear ... | NA | {
"id": "C0008996",
"name": "clofazamine",
"pos": [
15,
26
]
} | {
"id": "C0031375",
"name": "phenazine",
"pos": [
115,
124
]
} |
gliotoxin , a metabolite of the fungus aspergillus fumigatus , inhibited phagocytosis of particulate matter by rodent macrophages . | NA | {
"id": "C0004034",
"name": "fungus aspergillus",
"pos": [
32,
50
]
} | {
"id": "C0004037",
"name": "fumigatus",
"pos": [
51,
60
]
} |
effects of retinoic acid on hepatic cytochrome p-450 dependent enzymes in rats under different vitamin a status . | NA | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
11,
24
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
95,
104
]
} |
parallel to a sparing effect on liver reserves of vitamin a , retinoic acid maintained a normal activity of enzymes of xenobiotic metabolism . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
50,
59
]
} | {
"id": "C0040845",
"name": "retinoic acid",
"pos": [
62,
75
]
} |
the results indicate that the metabolism of mushroom-se is different from that of wheat-se or sodium selenate . | NA | {
"id": "C0036581",
"name": "se",
"pos": [
53,
55
]
} | {
"id": "C0074765",
"name": "sodium selenate",
"pos": [
94,
109
]
} |
incubation of rbcs with dl-alpha-tocopheryl acetate , at doses near to the plasma concentration in rat ( 6 micrograms/ml ) did not modify the osmotic fragility of rbcs but increasing doses of tocopherol induces changes in osmotic fragility which directly parallelled the vitamin e concentrations . | NA | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
24,
51
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
271,
280
]
} |
data from osmotic fragility after preincubation with dl-alpha-tocopheryl acetate and later incubation with these oxidizing drugs point to a possible toxic effect of higher dose vitamin e supplementation rather to a protective role on membrane stability . | NA | {
"id": "C0994472",
"name": "dl-alpha-tocopheryl acetate",
"pos": [
53,
80
]
} | {
"id": "C0042874",
"name": "vitamin e",
"pos": [
177,
186
]
} |
it was found that in rats in which the peritoneum layer was sutured a significantly higher amount of adhesion to scar developed . | NA | {
"id": "C0001511",
"name": "adhesion",
"pos": [
101,
109
]
} | {
"id": "C2004491",
"name": "scar",
"pos": [
113,
117
]
} |
these compounds may be protease-antiprotease complexes caused by tumour excretion of proteases into the serous effusions . | NA | {
"id": "C0030946",
"name": "protease",
"pos": [
23,
31
]
} | {
"id": "C0030940",
"name": "proteases",
"pos": [
85,
94
]
} |
rural patients were more often withdrawn , disoriented , confused/delirious and lacking contact in communication than urban patients ; | NA | {
"id": "C0009676",
"name": "confused",
"pos": [
57,
65
]
} | {
"id": "C0011206",
"name": "delirious",
"pos": [
66,
75
]
} |
freshly harvested cells from m3 , the less metastatic tumor , exhibited a similar low affinity for fibronectin , laminin , type iv collagen and the control protein albumin , while the highly metastatic mm3 cells attached preferentially to fibronectin . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
156,
163
]
} | {
"id": "C0001924",
"name": "albumin",
"pos": [
164,
171
]
} |
mediators of the reaction include reactive oxygen species , particularly singlet oxygen , that may elicit lipid peroxidation and the activation of complement . | NA | {
"id": "C0162772",
"name": "reactive oxygen species",
"pos": [
34,
57
]
} | {
"id": "C0074565",
"name": "singlet oxygen",
"pos": [
73,
87
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.