text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the repetitive polynucleotides polyinosinic and polyguanylic acid and their deoxyanalogues , actin and vimentin , were found to have the antigenic epitope . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
137,
146
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
147,
154
]
} |
there are two distinct patterns of binding , either as low molecular weight immune complexes or as free antibody directed against collagen . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
76,
92
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
104,
112
]
} |
fibroblasts migrate in vitro in response to a variety of chemoattractants including cellular , humoral , and connective tissue components . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
0,
11
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
84,
92
]
} |
patients in the acute phase of the disease failed to respond to partially purified nuclear antigen , ebna , or to cell extracts that contained ebna as the predominant ebv antigen . | NA | {
"id": "C0069115",
"name": "nuclear antigen",
"pos": [
83,
98
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
171,
178
]
} |
they showed a strong specific response to cell extracts enriched in early antigen ( ea ) and virus capsid antigen ( vca ) . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
74,
81
]
} | {
"id": "C0003342",
"name": "virus",
"pos": [
93,
98
]
} |
we report on a 5-year , prospective , double-blind trial of 1,25 dihydroxycholecalciferol ( calcitriol ) versus placebo in 76 hemodialysis patients without biochemical or radiological evidence of bone disease . | NA | {
"id": "C0012328",
"name": "dihydroxycholecalciferol",
"pos": [
65,
89
]
} | {
"id": "C0006674",
"name": "calcitriol",
"pos": [
92,
102
]
} |
we suggest that the fibrinopeptide a is produced intraperitoneally and the antithrombin iii-concentration in dialysate is sufficient to inhibit the fibrin formation after acceleration by heparin . | NA | {
"id": "C0016022",
"name": "fibrinopeptide a",
"pos": [
20,
36
]
} | {
"id": "C0015982",
"name": "fibrin",
"pos": [
148,
154
]
} |
untreated patients with a chronic progressive ms have higher t-helper cell ( okt4+ ) counts and a higher ratio okt4+/okt8+ than other ms patients , ond or healthy controls . | NA | {
"id": "C0393665",
"name": "chronic progressive ms",
"pos": [
26,
48
]
} | {
"id": "C0026769",
"name": "ms",
"pos": [
134,
136
]
} |
in comparison , for co-trimoxazole , the proportion of sulphamethoxazole eliminated in urine is 15 % , that of the acetylated derivative 47 % , and that of trimethoprim is also 75 % . | NA | {
"id": "C0041044",
"name": "co-trimoxazole",
"pos": [
20,
34
]
} | {
"id": "C0038689",
"name": "sulphamethoxazole",
"pos": [
55,
72
]
} |
this enhanced response to exogenous dopamine can be considered as a further argument favoring the existence of a deficit in dopaminergic activity during hypertension . | NA | {
"id": "C0013030",
"name": "dopamine",
"pos": [
36,
44
]
} | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
124,
136
]
} |
to determine whether pinacidil 's metabolism or effects were influenced by either liver disease or the subject 's debrisoquin phenotype , eight patients with chronic stable cirrhosis and 13 healthy subjects were studied . | NA | {
"id": "C0023895",
"name": "liver disease",
"pos": [
82,
95
]
} | {
"id": "C0023890",
"name": "cirrhosis",
"pos": [
173,
182
]
} |
isradipine ( sandoz pn 200-110 ) , a new dihydropyridine calcium channel antagonist , was evaluated in a randomized , double-blind , placebo-controlled trial for antihypertensive efficacy in 24 patients with essential hypertension . | NA | {
"id": "C0071304",
"name": "isradipine",
"pos": [
0,
10
]
} | {
"id": "C2945601",
"name": "dihydropyridine calcium",
"pos": [
41,
64
]
} |
since the insulin-like stimulatory effect of human igg on adipocyte lipogenesis , exerted through its fc moiety , is not neutralized by anti-insulin antisera , igg may contribute significantly to the non-suppressible insulin-like activity ( nsila ) of plasma . | NA | {
"id": "C0795635",
"name": "insulin",
"pos": [
10,
17
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
217,
224
]
} |
neither igg nor nsilp stimulate 35s-sulphate uptake by porcine cartilage , unlike serum somatomedin and crude nsila-s preparations ; | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
88,
99
]
} | {
"id": "C0028318",
"name": "nsila",
"pos": [
110,
115
]
} |
radiographic films of 40 patients participating in a single centre patient blind study of auranofin versus aurothioglucose were evaluated in a random order by one reader . | NA | {
"id": "C0004320",
"name": "auranofin",
"pos": [
90,
99
]
} | {
"id": "C0018033",
"name": "aurothioglucose",
"pos": [
107,
122
]
} |
a regimen of physical therapy ( pressure therapy , antalgic electrotherapy and exercise therapy ) with or without calcitonin was investigated in 24 patients randomly assigned to 2 groups , one given physical therapy alone ( group i ) and the other physical therapy plus salmon calcitonin 100 mrc units daily for 3 weeks ... | NA | {
"id": "C0006668",
"name": "calcitonin",
"pos": [
114,
124
]
} | {
"id": "C0073994",
"name": "salmon calcitonin",
"pos": [
270,
287
]
} |
established therapeutic agents include penicillins , aminoglycosides , and chloramphenicol , though newer expanded-spectrum cephalosporins such as cefuroxime , ceftriaxone , and cefotaxime are being used with increasing frequency . | NA | {
"id": "C0007562",
"name": "cefuroxime",
"pos": [
147,
157
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
178,
188
]
} |
established therapeutic agents include penicillins , aminoglycosides , and chloramphenicol , though newer expanded-spectrum cephalosporins such as cefuroxime , ceftriaxone , and cefotaxime are being used with increasing frequency . | NA | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
160,
171
]
} | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
178,
188
]
} |
ludwig 's angina ( la ) is an infection of the submandibular and sublingual spaces usually initiated by abscesses of the inferior molars due to mixed oral flora . | NA | {
"id": "C0024081",
"name": "ludwig 's angina",
"pos": [
0,
16
]
} | {
"id": "C0009450",
"name": "infection",
"pos": [
30,
39
]
} |
the oxidation of p5c ( glutamic acid semialdehyde ) by a mitochondrial dehydrogenase may be the same enzyme that oxidizes succinic acid semi-aldehyde but different from that oxidizing acetaldehyde . | NA | {
"id": "C0001992",
"name": "aldehyde",
"pos": [
41,
49
]
} | {
"id": "C0000966",
"name": "acetaldehyde",
"pos": [
184,
196
]
} |
immunoprecipitation of the labelled translation products or of serum proteins showed that the mrna activity and the synthesis of alpha 1-acid glycoprotein , an acute phase reactant , was elevated by the methylmercury treatment as well as by the turpentine-induced inflammatory response . | NA | {
"id": "C0029297",
"name": "alpha 1-acid glycoprotein",
"pos": [
129,
154
]
} | {
"id": "C0001347",
"name": "acute phase reactant",
"pos": [
160,
180
]
} |
receptors exhibited a high degree of specificity for leu-enkephalin as evidenced by the poor competition shown by a variety of enkephalin analogues and naloxone and the lack of effect of other unrelated peptides present in the intestinal tract . | NA | {
"id": "C0014294",
"name": "leu-enkephalin",
"pos": [
53,
67
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
127,
137
]
} |
using the medaka , oryzias latipes ( orange-red variety ) , the mechanisms of action on leucophores of adenosine and adenine nucleotides , including cyclic amp , were studied . | NA | {
"id": "C0001413",
"name": "adenine nucleotides",
"pos": [
117,
136
]
} | {
"id": "C0001455",
"name": "cyclic amp",
"pos": [
149,
159
]
} |
toxicity of cadmium administration to the toad and the treatment of its poisoning with edta . | NA | {
"id": "C0006635",
"name": "toxicity",
"pos": [
0,
8
]
} | {
"id": "C0032343",
"name": "poisoning",
"pos": [
72,
81
]
} |
the lipid composition of the various lipoprotein fractions was estimated after separation in a density gradient by ultracentrifugation . | NA | {
"id": "C0023779",
"name": "lipid",
"pos": [
4,
9
]
} | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
37,
48
]
} |
gold entered the eye and was accumulated in the aqueous humor , iris-ciliary body , and cornea ( measured by flameless atomic absorption spectroscopy ) of rabbits given gold sodium thiomalate by subcutaneous infusion for 4 weeks . | NA | {
"id": "C0018026",
"name": "gold",
"pos": [
0,
4
]
} | {
"id": "C0018034",
"name": "gold sodium thiomalate",
"pos": [
169,
191
]
} |
as a first step in an ongoing study on the correlation of oncogene expression and tumorigenicity in hybrids made by fusing d98ah2 ( d98 ) carcinoma cells with normal diploid human fibroblasts , we determined which oncogenes are expressed in the d98 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
180,
191
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
249,
254
]
} |
by combining anion exchange chromatography , gel filtration , agarose gel electrophoresis , hydrophobic interaction chromatography , and affinity chromatography on iminodiacetic acid-sepharose cl 4b and lysine sepharose 4b we were able to isolate seven different water soluble reiter antigens from one single reiter soni... | NA | {
"id": "C0003075",
"name": "anion",
"pos": [
13,
18
]
} | {
"id": "C0021966",
"name": "i",
"pos": [
364,
365
]
} |
cell-by-cell autofluorescence correction for low signal-to-noise systems : application to epidermal growth factor endocytosis by 3t3 fibroblasts . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
0,
4
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
133,
144
]
} |
a dose of 20 mg alpha-tocopherol acetate ( alpha-t-ac ) was injected subcutaneously in 5 premature newborns . alpha-t-ac and alpha-t were assayed by high-pressure liquid chromatography . | NA | {
"id": "C1999896",
"name": "alpha-tocopherol acetate",
"pos": [
16,
40
]
} | {
"id": "C0969677",
"name": "alpha-t",
"pos": [
125,
132
]
} |
the main symptoms are epiphora , pain and inflammation in the medial canthal area and headache . | NA | {
"id": "C0030193",
"name": "pain",
"pos": [
33,
37
]
} | {
"id": "C0018681",
"name": "headache",
"pos": [
86,
94
]
} |
this disposition of acetaminophen was examined in an overfed rat model of human obesity following iv administration of a subtoxic 303 +/- 5 mg/kg dose based upon ideal body weight . | NA | {
"id": "C1257763",
"name": "overfed",
"pos": [
53,
60
]
} | {
"id": "C0028754",
"name": "obesity",
"pos": [
80,
87
]
} |
small-cell bronchial carcinoma is most probably present in patients with bronchial carcinoma and neuron-specific enolase serum concentrations above 25 micrograms/l . | NA | {
"id": "C0149925",
"name": "small-cell",
"pos": [
0,
10
]
} | {
"id": "C0007121",
"name": "bronchial carcinoma",
"pos": [
73,
92
]
} |
in a randomized cross-over trial of four groups of patients ( total 49 patients ) the serum concentrations of isosorbide dinitrate ( isdn ) , isosorbide-2-mononitrate ( is-2-mn ) and isosorbide-5-mononitrate ( is-5-mn ) were measured under steady-state conditions after administration of 20 , 40 , 60 and 80 mg , respect... | NA | {
"id": "C0064079",
"name": "isosorbide-5-mononitrate",
"pos": [
183,
207
]
} | {
"id": "C0022252",
"name": "isdn",
"pos": [
335,
339
]
} |
three opioid peptide systems [ i.e . endorphin ( end ) , enkephalin , dynorphin ( dyn ) ] , are present in the hypothalamus , acting on different opiate receptor subtypes ( i.e . mu , delta , kappa ) . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
6,
20
]
} | {
"id": "C0014242",
"name": "endorphin",
"pos": [
37,
46
]
} |
three opioid peptide systems [ i.e . endorphin ( end ) , enkephalin , dynorphin ( dyn ) ] , are present in the hypothalamus , acting on different opiate receptor subtypes ( i.e . mu , delta , kappa ) . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
6,
20
]
} | {
"id": "C0014298",
"name": "enkephalin",
"pos": [
57,
67
]
} |
three opioid peptide systems [ i.e . endorphin ( end ) , enkephalin , dynorphin ( dyn ) ] , are present in the hypothalamus , acting on different opiate receptor subtypes ( i.e . mu , delta , kappa ) . | NA | {
"id": "C0205753",
"name": "opioid peptide",
"pos": [
6,
20
]
} | {
"id": "C0013355",
"name": "dynorphin",
"pos": [
70,
79
]
} |
in addition , the effects of four other types of benzodiazepine ( flurazepam , chlordiazepoxide , midazolam , and medazepam ) , all tested at a 10-nm concentration , corroborated these findings . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
49,
63
]
} | {
"id": "C0008188",
"name": "chlordiazepoxide",
"pos": [
79,
95
]
} |
in addition , the effects of four other types of benzodiazepine ( flurazepam , chlordiazepoxide , midazolam , and medazepam ) , all tested at a 10-nm concentration , corroborated these findings . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
49,
63
]
} | {
"id": "C0026056",
"name": "midazolam",
"pos": [
98,
107
]
} |
in addition , the effects of four other types of benzodiazepine ( flurazepam , chlordiazepoxide , midazolam , and medazepam ) , all tested at a 10-nm concentration , corroborated these findings . | NA | {
"id": "C0005064",
"name": "benzodiazepine",
"pos": [
49,
63
]
} | {
"id": "C0025051",
"name": "medazepam",
"pos": [
114,
123
]
} |
under these conditions gtp and the gtp analog , guanylylimidodiphosphate ( gmp-pnp ) , stimulated a time- and dose-dependent increase in lh release and inositol phosphate accumulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
23,
26
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
75,
82
]
} |
these actions of gtp and gmp-pnp were not observed unless atp was included in the treatment media . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
17,
20
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
25,
32
]
} |
we also evaluated the actions of pertussis toxin and cholera toxin on mediating the effect of gtp , gmp-pnp , and gnrh on lh release and inositol phosphate accumulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
94,
97
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
100,
107
]
} |
after treatment with these agents , no changes were observed in the ability of gnrh , gtp , or gmp-pnp to stimulate either lh release or inositol phosphate accumulation . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
86,
89
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
95,
102
]
} |
the additional observation that gnrh- , gtp- , or gmp-pnp-stimulated lh release and inositol phosphate accumulation were blocked by a potent gnrh antagonist suggests that a g protein is functionally associated with the gnrh receptor recognition site . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
40,
43
]
} | {
"id": "C0018366",
"name": "gmp-pnp",
"pos": [
50,
57
]
} |
depletion of hypothalamic norepinephrine ( ne ) and epinephrine by administration of diethyldithiocarbamate abolished the stimulatory effects of intraventricular ( ivt ) angiotensin ii ( aii ) on lh release in ovariectomized rats pretreated with estradiol and progesterone . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
26,
40
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
52,
63
]
} |
aii receptor blockade with ivt saralasin prevented the lh rise due to aii without modifying that due to ne . | NA | {
"id": "C0036193",
"name": "saralasin",
"pos": [
31,
40
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
70,
73
]
} |
these findings demonstrate that e2 has a direct inhibitory action on expression of pituitary aii receptors that is not accompanied by a decrease in aii-stimulated prl secretion . | NA | {
"id": "C0003018",
"name": "aii",
"pos": [
93,
96
]
} | {
"id": "C0003009",
"name": "aii",
"pos": [
148,
151
]
} |
proglucagon , synthesized in the pancreatic islets and the intestinal l-cells , contains in its precursor structure glucagon , glicentin , and two glucagon-like peptides ( glp-i and glp-ii ) separated by an intervening peptide ( ip-ii ) . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
0,
11
]
} | {
"id": "C0061309",
"name": "glicentin",
"pos": [
127,
136
]
} |
proglucagon , synthesized in the pancreatic islets and the intestinal l-cells , contains in its precursor structure glucagon , glicentin , and two glucagon-like peptides ( glp-i and glp-ii ) separated by an intervening peptide ( ip-ii ) . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
0,
11
]
} | {
"id": "C0014361",
"name": "glucagon-like",
"pos": [
147,
160
]
} |
in contrast to the processing of proglucagon in the pancreas , in which glucagon is liberated , in the cell line we found the intestinal pattern of peptides consisting of glicentin , at least two forms of glp-i [ glp-i- ( 1-37 ) and glp-i- ( 7-37 ) ] , glp-ii , ip-ii , and an amidated form of ip-ii . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
33,
44
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
72,
80
]
} |
in contrast to the processing of proglucagon in the pancreas , in which glucagon is liberated , in the cell line we found the intestinal pattern of peptides consisting of glicentin , at least two forms of glp-i [ glp-i- ( 1-37 ) and glp-i- ( 7-37 ) ] , glp-ii , ip-ii , and an amidated form of ip-ii . | NA | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
33,
44
]
} | {
"id": "C0061309",
"name": "glicentin",
"pos": [
171,
180
]
} |
the existence of a single glucagon gene in the rat genome and indistinguishable glucagon mrnas in pancreas and intestine indicates that the neoplastic transformation that occurred in these islet cells is associated with a phenotypic switch in the differential posttranslational processing of proglucagon to a pattern tha... | NA | {
"id": "C0017687",
"name": "glucagon",
"pos": [
26,
34
]
} | {
"id": "C0072092",
"name": "proglucagon",
"pos": [
292,
303
]
} |
incubating the cells with the ca++ channel antagonists d600 ( 50 microm ) , verapamil ( 50 microm ) , and the dihydropyridine nifedipine ( 0.1 microm ) decreased basal pomc mrna levels , whereas the dihydropyridine bayk 8644 ( 0.1 microm ) , which activates the ca++ channel , increased pomc mrna levels after 2 days . | NA | {
"id": "C0028066",
"name": "nifedipine",
"pos": [
126,
136
]
} | {
"id": "C0012315",
"name": "dihydropyridine",
"pos": [
199,
214
]
} |
compared with former reports , idiopathic inflammatory bowel disease ( iibd ) such as crohn 's disease ( 32.2 % ) and ulcerative colitis ( 18.4 % ) were decreased . | NA | {
"id": "C0021390",
"name": "inflammatory bowel disease",
"pos": [
42,
68
]
} | {
"id": "C0010346",
"name": "disease",
"pos": [
95,
102
]
} |
to elucidate the mechanisms of stimulatory actions of gnrh on rat granulosa cells ( gc ) , we have compared the actions of a gnrh agonist with those of a tumor-promoting phorbol ester , 12-0-tetradecanoylphorbol 13-acetate ( tpa ) and ca+2 ionophore , a23187 . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
170,
183
]
} | {
"id": "C0039654",
"name": "tetradecanoylphorbol",
"pos": [
191,
211
]
} |
in combination with tpa , gnrha had no influence on tpa-stimulated pg synthase activity , but increased pge accumulation to levels comparable to those with a23187 plus tpa . | NA | {
"id": "C0033554",
"name": "pg",
"pos": [
67,
69
]
} | {
"id": "C0033559",
"name": "pge",
"pos": [
104,
107
]
} |
the regulation of dna synthesis in 19 day rat fetal lung epithelial ( alveolar type ii ) and mesenchymal ( fibroblast ) cells by protein growth factors has been studied . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
107,
117
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
120,
125
]
} |
norepinephrine concentrations and tyrosine hydroxylase activity were determined in the brains of moderate-seizure and severe-seizure genetically epilepsy-prone rats ( geprs ) and in nonepileptic control rats . | NA | {
"id": "C0036572",
"name": "seizure",
"pos": [
106,
113
]
} | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
145,
153
]
} |
this phenomenon of drug-induced seizures is apt to occur particularly in certain types of childhood epilepsy that are refractory to therapy and are accompanied by slow spike-wave discharges in the eeg , such as the lennox-gastaut syndrome . | NA | {
"id": "C0036572",
"name": "seizures",
"pos": [
32,
40
]
} | {
"id": "C0014544",
"name": "types",
"pos": [
81,
86
]
} |
this phenomenon of drug-induced seizures is apt to occur particularly in certain types of childhood epilepsy that are refractory to therapy and are accompanied by slow spike-wave discharges in the eeg , such as the lennox-gastaut syndrome . | NA | {
"id": "C0014544",
"name": "types",
"pos": [
81,
86
]
} | {
"id": "C0238111",
"name": "lennox-gastaut syndrome",
"pos": [
215,
238
]
} |
the academic achievement scores of 122 children with epilepsy were examined in relation to demographic and clinical seizure variables . | NA | {
"id": "C0014544",
"name": "epilepsy",
"pos": [
53,
61
]
} | {
"id": "C0036572",
"name": "seizure",
"pos": [
116,
123
]
} |
the effects of excision repair and presence of plasmid pkm101 on the mutagenicities and cytotoxicities of the anthracycline derivatives adriamycin , daunomycin , carminomycin , and 4-demethoxydoxorubicin were examined in strains of salmonella typhimurium . | NA | {
"id": "C0011015",
"name": "daunomycin",
"pos": [
149,
159
]
} | {
"id": "C0007308",
"name": "carminomycin",
"pos": [
162,
174
]
} |
male mice ( c57bl/6j ) at 2 weeks of age were divided into two groups and maintained on a vitamin a-deficient or vitamin a- ( retinyl acetate ) supplemented diet . | NA | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
90,
99
]
} | {
"id": "C0073109",
"name": "retinyl acetate",
"pos": [
126,
141
]
} |
heavy metal intoxication with cd and hg causes proximal tubular abnormalities , i.e. , aminoaciduria , glycosuria , phosphaturia . | NA | {
"id": "C0347988",
"name": "heavy metal",
"pos": [
0,
11
]
} | {
"id": "C0025424",
"name": "hg",
"pos": [
37,
39
]
} |
cupric sulfate was the most toxic of the three sulfates , but the differences between the toxicity of the aluminum sulfate and aluminum ammonium sulfate were less clear . | NA | {
"id": "C0056301",
"name": "cupric sulfate",
"pos": [
0,
14
]
} | {
"id": "C0038720",
"name": "sulfates",
"pos": [
47,
55
]
} |
clones encoding the angiogenic endothelial cell mitogen , basic fibroblast growth factor ( fgf ) , have been isolated from human cdna libraries made from kidney , fetal heart , fetal liver , term placenta , and a breast carcinoma . | NA | {
"id": "C0016026",
"name": "endothelial cell mitogen",
"pos": [
31,
55
]
} | {
"id": "C0380603",
"name": "basic fibroblast growth",
"pos": [
58,
81
]
} |
a human endothelial cdna expression library , based on the escherichia coli plasmid puc9 , was screened with a heterologous antibody raised against purified bovine aortic endothelial plasminogen activator inhibitor ( pai ) . | NA | {
"id": "C0030190",
"name": "endothelial plasminogen activator inhibitor",
"pos": [
171,
214
]
} | {
"id": "C0032145",
"name": "pai",
"pos": [
217,
220
]
} |
certain newly established epstein-barr virus-containing burkitt 's lymphoma cell lines do not express the cytotoxic t-lymphocyte-detected membrane antigen ( lydma ) through which ebv infection is normally controlled by the host . | NA | {
"id": "C0006413",
"name": "burkitt 's lymphoma",
"pos": [
56,
75
]
} | {
"id": "C0149678",
"name": "ebv infection",
"pos": [
179,
192
]
} |
we have identified a class of transformed nih3t3 mouse fibroblasts that arise at low frequencies in transfection experiments with dna from both neoplastic and non-neoplastic cells and that may result from a low level of spontaneous transformation of nih3t3 cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
55,
66
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
257,
262
]
} |
antibody effects on assembly and competitive binding data indicate these antibodies bind to two sites , critical for clathrin interactions , located in the same region of the clathrin heavy chain . | NA | {
"id": "C0008905",
"name": "clathrin",
"pos": [
117,
125
]
} | {
"id": "C0530079",
"name": "clathrin heavy chain",
"pos": [
175,
195
]
} |
whereas gp 80 from the serum is glycosylated with complex-type oligosaccharides , gp 80 from the plasma membrane has high mannose glycans . | NA | {
"id": "C0028959",
"name": "oligosaccharides",
"pos": [
63,
79
]
} | {
"id": "C0032594",
"name": "glycans",
"pos": [
130,
137
]
} |
phase iii cells also respond to pdgf by rapid actin reorganization and increased levels of c-fos and c-myc mrna , similar to growth-arrested phase ii fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
10,
15
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
150,
161
]
} |
low concentrations of the synthetic glucocorticoid , dexamethasone ( dex ) , reduce urokinase-type pa mrna levels in two cell types , namely a human fibrosarcoma line , ht1080 , and synovial fibroblast-like cells isolated from human joints . | NA | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
191,
201
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
207,
212
]
} |
the nucleotide sequence of the fission yeast dna topoisomerase ii gene : structural and functional relationships to other dna topoisomerases . | NA | {
"id": "C0012863",
"name": "dna topoisomerase ii",
"pos": [
45,
65
]
} | {
"id": "C0949775",
"name": "dna topoisomerases",
"pos": [
122,
140
]
} |
injections of talc failed to cause arachnoiditis or meningitis probably because sufficient particulate talc could not be injected through the narrow catheter . | NA | {
"id": "C0003708",
"name": "arachnoiditis",
"pos": [
35,
48
]
} | {
"id": "C0025289",
"name": "meningitis",
"pos": [
52,
62
]
} |
urinary adrenaline , noradrenaline , heart rate , and subjective ratings were obtained from 9 healthy males during six different physical activities , ranging in intensity from lying down to running . | NA | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
8,
18
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
21,
34
]
} |
the ingestion of glucose ( lg x kg-1 body weight ) 45 min before exercise produced a 50 % rise in blood glucose and a 3-fold rise in plasma insulin at zero min of exercise . | NA | {
"id": "C0017725",
"name": "glucose",
"pos": [
17,
24
]
} | {
"id": "C0005802",
"name": "in blood glucose",
"pos": [
95,
111
]
} |
the in vitro activity of tetracycline , ciprofloxacin and two recently developed 1-aryl-fluoroquinolones , a56610 and a56620 , was tested against 65 beta-lactamase-negative and 35 beta-lactamase-positive neisseria gonorrhoeae strains , 12 chlamydia trachomatis , 50 mycoplasma hominis , 28 ureaplasma urealyticum and 50 ... | NA | {
"id": "C0008809",
"name": "ciprofloxacin",
"pos": [
40,
53
]
} | {
"id": "C0949665",
"name": "fluoroquinolones",
"pos": [
88,
104
]
} |
over 80 % of the number of synthesized dna molecules comprised a single population of short dna fragments ( 60-200 bases , on average 120 bases in length ) and the number of fragments increased , depending on the incubation time . | NA | {
"id": "C0012854",
"name": "dna",
"pos": [
39,
42
]
} | {
"id": "C0000702",
"name": "a",
"pos": [
218,
219
]
} |
the sequential polypeptides ( l-arg-xaa-gly ) n where xaa represents amino acid residues ala , val and leu , were employed as models of arginine-rich histones , in studying their interactions with nucleic acids . | NA | {
"id": "C0017890",
"name": "gly",
"pos": [
40,
43
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
69,
79
]
} |
in the presence of f1 no antibody recognition could be observed with the anti-a antisera , while anti-b and anti-c antisera showed strong binding . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
25,
33
]
} | {
"id": "C0020960",
"name": "antisera",
"pos": [
115,
123
]
} |
the relative distribution of three glycine-enzyme complexes shows only small differences between the native and trypsin-digested enzyme . | NA | {
"id": "C0026741",
"name": "enzyme",
"pos": [
43,
49
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
129,
135
]
} |
these results , together with the data on smith degradation of the synthesized polysaccharide , indicate that the repeating trisaccharide units of the main chain of the polysaccharide arise from the galnac-mannac-glcnac moiety of the glycolipid intermediates and that the sugar residues in the lateral branches of the po... | NA | {
"id": "C0041102",
"name": "trisaccharide",
"pos": [
124,
137
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
365,
380
]
} |
these results , together with the data on smith degradation of the synthesized polysaccharide , indicate that the repeating trisaccharide units of the main chain of the polysaccharide arise from the galnac-mannac-glcnac moiety of the glycolipid intermediates and that the sugar residues in the lateral branches of the po... | NA | {
"id": "C0032594",
"name": "polysaccharide",
"pos": [
79,
93
]
} | {
"id": "C0028959",
"name": "oligosaccharide",
"pos": [
365,
380
]
} |
rat pepsinogen has an amino acid composition characteristic of c-type pepsinogens and is much more homologous in amino acid sequence with c-type pepsinogens than a-type pepsinogens . | NA | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
4,
14
]
} | {
"id": "C0030915",
"name": "c",
"pos": [
138,
139
]
} |
these results indicate that the major form of rat pepsinogen can be classified as a c type pepsinogen . | NA | {
"id": "C0030913",
"name": "pepsinogen",
"pos": [
50,
60
]
} | {
"id": "C0030915",
"name": "a c",
"pos": [
82,
85
]
} |
the enzyme propylamine transferase , catalyzing the transfer of the propylamine moiety from s-adenosyl ( 5 ' ) -3-methylthiopropylamine to several amine acceptors , has been purified 643-fold in 20 % yield from sulfolobus solfataricus , an extreme thermophilic archaebacterium optimally growing at 87 degrees c . | NA | {
"id": "C0033504",
"name": "propylamine",
"pos": [
11,
22
]
} | {
"id": "C0002508",
"name": "amine",
"pos": [
147,
152
]
} |
the lipopolysaccharide consisted of the r form , containing per mole , three moles of l-glycero-d-manno-heptopyranose , one mole of 3-deoxy-d-manno-2-octulosonic acid ( docla ) and lipid a . | NA | {
"id": "C0023810",
"name": "lipopolysaccharide",
"pos": [
4,
22
]
} | {
"id": "C0023767",
"name": "lipid a",
"pos": [
181,
188
]
} |
the oxygen affinity of hb-icbs and alpha 2icbs beta 2 is independent of chloride concentration , while the alpha 2 beta 2icbs hybrid shows a reduced response to this anion . | NA | {
"id": "C0008203",
"name": "chloride",
"pos": [
72,
80
]
} | {
"id": "C0003075",
"name": "anion",
"pos": [
166,
171
]
} |
among a series of inositol phosphates containing between one and six phosphates and varying in their positions , inositol 1,4,5-trisphosphate was found to be bound strongest both by aldolase a [ ( l ] 0.5 = 0.58 microm ) and aldolase b [ ( l ] 0.5 = 0.83 microm ) . | NA | {
"id": "C0021554",
"name": "inositol phosphates",
"pos": [
18,
37
]
} | {
"id": "C0021547",
"name": "inositol",
"pos": [
113,
121
]
} |
the size of the oligo ( ra ) and oligo ( rg ) primer molecules has been determined by urea/polyacrylamide gel electrophoresis : longer oligoribonucleotides are synthesized when their utilization is prevented by omitting dntp . | NA | {
"id": "C0028953",
"name": "oligo",
"pos": [
16,
21
]
} | {
"id": "C0028956",
"name": "oligoribonucleotides",
"pos": [
135,
155
]
} |
the scintigraphic evaluation of myocardial infarction and regional ventricular performance using technetium-99m hexakis ( t-butylisonitrile ) technetium ( i ) ( tbi ) : a new myocardial imaging agent . | NA | {
"id": "C0303611",
"name": "technetium-99m",
"pos": [
97,
111
]
} | {
"id": "C0039411",
"name": "technetium",
"pos": [
142,
152
]
} |
living cells from 14 thymuses were also cocultivated with monkey cell lines and with human embryonic lung fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
7,
12
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
106,
117
]
} |
a variety of lipids , lipoprotein ( lp ) lipids and apo-lp were measured in 72 patients of both sexes suffering from cerebrovascular arteriopathy and compared with a control group matched for age and sex . | NA | {
"id": "C0023820",
"name": "lipoprotein",
"pos": [
22,
33
]
} | {
"id": "C0023779",
"name": "lipids",
"pos": [
41,
47
]
} |
from october 1983 , ( installation of the extracorporeal shock wave lithotripsy unit ) to august 1985 , 207 patients presented at the katharinenhospital stuttgart with complicated renal stone disease ( 70 borderline stones , 77 partial and 60 complete staghorn calculi ) . | NA | {
"id": "C0022650",
"name": "renal stone",
"pos": [
180,
191
]
} | {
"id": "C0333014",
"name": "staghorn calculi",
"pos": [
252,
268
]
} |
failure of indomethacin to impair the diuretic and natriuretic effects of the loop diuretic torasemide in healthy volunteers . | NA | {
"id": "C0012798",
"name": "diuretic",
"pos": [
38,
46
]
} | {
"id": "C0354100",
"name": "loop diuretic",
"pos": [
78,
91
]
} |
when the antigen bears an epitope recognized by the specific b cell , the subsequent presentation of this antigen is 10 ( 2 ) -10 ( 4 ) -fold more efficient , as compared to the same , but nonhaptenated protein . | NA | {
"id": "C0003320",
"name": "antigen",
"pos": [
9,
16
]
} | {
"id": "C0003316",
"name": "epitope",
"pos": [
26,
33
]
} |
to investigate cellular mechanisms controlling activated autoreactive t lymphocytes , a limiting dilution system was established employing cloned autoreactive major histocompatibility complex class ii specific lymphocytes ( a2/7 ) as stimulator cells for autologous peripheral blood mononuclear cells . | NA | {
"id": "C0007634",
"name": "cellular",
"pos": [
15,
23
]
} | {
"id": "C1321301",
"name": "cells",
"pos": [
295,
300
]
} |
in addition , a potent relaxant effect occurred when supramaximal concentrations of noradrenaline and adrenaline , but not of phenylephrine , were used . | NA | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
84,
97
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
102,
112
]
} |
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