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immunosuppression due to various disease states or treatments had been accompanied by malignant tumors , often lymphomas in unusual sites such as the central nervous system .
nichd_parent_of
{ "id": "C0006826", "name": "malignant tumors", "pos": [ 86, 102 ] }
{ "id": "C0024299", "name": "lymphomas", "pos": [ 111, 120 ] }
clinical signs of toxicosis included decreased feed consumption during afb1 administration , loss of body weight or failure to gain , and death .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0011065", "name": "death", "pos": [ 138, 143 ] }
typical clinical signs of toxicosis were manifested as ataxia on day 8 and tremor on day 11 .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 8, 22 ] }
{ "id": "C0040822", "name": "tremor", "pos": [ 75, 81 ] }
clinical signs of mcf included a mucopurulent catarrh , pyrexia ( 38.8 to 42.1 c ) , anorexia , and corneal opacity , and death occurred between postinoculation days 15 and 21 .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0015967", "name": "pyrexia", "pos": [ 56, 63 ] }
clinical signs of mcf included a mucopurulent catarrh , pyrexia ( 38.8 to 42.1 c ) , anorexia , and corneal opacity , and death occurred between postinoculation days 15 and 21 .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0003123", "name": "anorexia", "pos": [ 85, 93 ] }
clinical signs of mcf included a mucopurulent catarrh , pyrexia ( 38.8 to 42.1 c ) , anorexia , and corneal opacity , and death occurred between postinoculation days 15 and 21 .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0011065", "name": "death", "pos": [ 122, 127 ] }
all inoculated cats had clinical signs of feline cytauxzoonosis and died within 2 weeks after they were inoculated .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 24, 38 ] }
{ "id": "C0011065", "name": "died", "pos": [ 68, 72 ] }
all inoculated cats developed a parasitemia , but none developed clinical signs of disease and none died of the disease .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 65, 79 ] }
{ "id": "C0011065", "name": "died", "pos": [ 100, 104 ] }
cats subinoculated with parasitemic cat blood also developed parasitemias and they too did not develop clinical signs of infection nor died .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 103, 117 ] }
{ "id": "C0011065", "name": "died", "pos": [ 135, 139 ] }
clinical signs were green mucohemorrhagic fecal material , partially prolapsed rectum , anorexia , body weight loss , and dehydration .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 0, 14 ] }
{ "id": "C0003123", "name": "anorexia", "pos": [ 88, 96 ] }
a booklet containing all possible pairings of the eight characteristics was distributed to 219 participants who were asked which member of each pair should have greater weight for assigning an overall interview grade .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 56, 71 ] }
{ "id": "C0005910", "name": "weight", "pos": [ 169, 175 ] }
certain well-tried operative techniques are described , from tendon transplantation to arthrodeses of joints , and the relative merits of each procedure are evaluated and placed in perspective .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 143, 152 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 157, 166 ] }
[ elaboration of the procedures for the pharmacokinetic interpretation of aminoglycoside nephrotoxicity : the experimental evaluation of the safety of repeated gentamycin administration ] .
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 21, 31 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 123, 133 ] }
young people who are regular smokers predominantly smoke middle tar cigarettes while among experimental smokers there is a high incidence of low tar smoking , which might suggest that such cigarettes facilitate the taking up of the habit in children .
nichd_parent_of
{ "id": "C0027361", "name": "people", "pos": [ 6, 12 ] }
{ "id": "C0008059", "name": "children", "pos": [ 241, 249 ] }
this concept places growth hormone in the unique position of being the main driver and co-ordinator during childhood and adolescence of bone growth an mineralisation on the one hand , and of blood mineral homeostasis on the other .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 107, 116 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 121, 132 ] }
the synovial tissue in experimentally induced immune arthritis induced in the rabbit has been used as a model of rheumatoid arthritis to determine which cells may contribute to the growth of this tissue .
nichd_parent_of
{ "id": "C0003864", "name": "arthritis", "pos": [ 53, 62 ] }
{ "id": "C0003873", "name": "rheumatoid arthritis", "pos": [ 113, 133 ] }
a combined procedure involving ligation of the vertebral vein and detachable balloon occlusion of the fistula was used in two instances without complications and with complete cure of the avf .
nichd_parent_of
{ "id": "C0016169", "name": "fistula", "pos": [ 102, 109 ] }
{ "id": "C0003855", "name": "avf", "pos": [ 188, 191 ] }
sex differences were seen in many parameters as expected , but statistically significant treatment related effects were observed only in the food maze learning behavior and in the pentobarbital sleeping time in the puberty aged male offspring .
nichd_parent_of
{ "id": "C0004927", "name": "behavior", "pos": [ 160, 168 ] }
{ "id": "C0037313", "name": "sleeping", "pos": [ 194, 202 ] }
the results indicate that further progress in life-events research will require prospective designs , more sophisticated methods for gathering life-events data than the schedule of recent experiences , focus on qualitative features of events ( eg , undesirability or threat ) , and identification of personal characteris...
nichd_parent_of
{ "id": "C0205556", "name": "qualitative", "pos": [ 211, 222 ] }
{ "id": "C0018684", "name": "health", "pos": [ 379, 385 ] }
isolates from two cases of acute measles , one case of acute measles encephalitis and three patients with subacute sclerosing panencephalitis were compared .
nichd_parent_of
{ "id": "C0014038", "name": "encephalitis", "pos": [ 69, 81 ] }
{ "id": "C0038522", "name": "subacute sclerosing panencephalitis", "pos": [ 106, 141 ] }
there was no difference between masseter inhibitory periods evoked in either painful or non-painful muscles , and no particular configuration associated with pain sensation .
nichd_parent_of
{ "id": "C0030193", "name": "painful", "pos": [ 77, 84 ] }
{ "id": "C0231528", "name": "painful muscles", "pos": [ 92, 107 ] }
recordings disclosed disordered breathing during sleep in the form of pronounced periodic breathing of alternating hypopneas and hyperpneas , isolated hypopneic episodes and central apneas and periodic sighs , all combined with electrophysiologic `` '' microarousals , '' '' and a mixture of alpha and delta eeg wave act...
nichd_parent_of
{ "id": "C0037315", "name": "disordered", "pos": [ 21, 31 ] }
{ "id": "C0520680", "name": "central", "pos": [ 174, 181 ] }
a second set of equations was evaluated for the calculation of 95 % -prediction intervals for the particular sti permitting to define abnormalities of the sti in individual children .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 162, 172 ] }
{ "id": "C0008059", "name": "children", "pos": [ 173, 181 ] }
when the peg assay was applied to a selected panel of 440 sera from patients with various well-defined autoimmune diseases and to a group of 197 normal human control sera , matched sex and age to the patients , the method was found to be fairly specific for systemic lupus erythematosus , although the sera from some pat...
nichd_parent_of
{ "id": "C0004364", "name": "autoimmune", "pos": [ 103, 113 ] }
{ "id": "C0026896", "name": "myasthenia gravis", "pos": [ 331, 348 ] }
the pathological changes in joints of the infected animals included pannus formation and erosion , resembling changes that occur in arthritis in man , including rheumatoid arthritis .
nichd_parent_of
{ "id": "C0003864", "name": "arthritis", "pos": [ 132, 141 ] }
{ "id": "C0003873", "name": "rheumatoid arthritis", "pos": [ 161, 181 ] }
thirty-seven percent of the fatal infections were due to fungi and the incidence of fungal infection was as high during the second week of treatment as later .
nichd_parent_of
{ "id": "C3714514", "name": "infections", "pos": [ 34, 44 ] }
{ "id": "C0026946", "name": "fungal infection", "pos": [ 84, 100 ] }
although this study is preliminary , the described technique can provide further information about the possible relationship between behavioral ( sleep and/or feeding ) changes and the concomitant neurochemical fluctuations .
nichd_parent_of
{ "id": "C0004927", "name": "behavioral", "pos": [ 133, 143 ] }
{ "id": "C0037313", "name": "sleep", "pos": [ 146, 151 ] }
rats were under pentobarbital anesthesia , urethane anesthesia or flaxedil neuromuscular blockage and local anesthesia , fasted and unfasted rats were compared .
nichd_parent_of
{ "id": "C0002903", "name": "anesthesia", "pos": [ 30, 40 ] }
{ "id": "C0002921", "name": "local anesthesia", "pos": [ 102, 118 ] }
in a retrospective analysis , we studied the effects of posttransfusion hepatitis ( non-a , non-b ) and chromosomal leukemia upon the overall times of adult patients with acute nonlymphocytic leukemia ( anll ) .
nichd_parent_of
{ "id": "C0023418", "name": "overall", "pos": [ 134, 141 ] }
{ "id": "C0023467", "name": "acute nonlymphocytic leukemia", "pos": [ 171, 200 ] }
the similarity of this disease to human and experimental cardiomyopathy suggests that microvascular spasm may be a common denominator of many different cardiomyopathic syndromes .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 23, 30 ] }
{ "id": "C0039082", "name": "syndromes", "pos": [ 168, 177 ] }
during spontaneous episodes of st elevation recorded in hospital , 56 of the 114 patients had serious arrhythmias : ventricular fibrillation in two , ventricular tachycardia in 28 , ventricular couplets or bigeminy in 17 , second- or third-degree atrioventricular block in six and asystole in three .
nichd_parent_of
{ "id": "C0003811", "name": "arrhythmias", "pos": [ 102, 113 ] }
{ "id": "C0151517", "name": "third-degree atrioventricular block", "pos": [ 234, 269 ] }
powerful statistical tests of data normality in the procedure help the user evaluate both the necessity for and the success of the data transformation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 52, 61 ] }
{ "id": "C0220825", "name": "evaluate", "pos": [ 76, 84 ] }
comparison of the clinical features of crohn 's disease and ulcerative colitis with onset in childhood or adolescence .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 93, 102 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 106, 117 ] }
a combination of hypoxia and adrenaline perfusion produced ventricular arrhythmias in each of twenty-three preparations : there were frequent ventricular premature contractions in eighteen preparations , and ventricular tachycardia or fibrillation in five preparations .
nichd_parent_of
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 59, 82 ] }
{ "id": "C0042514", "name": "ventricular tachycardia", "pos": [ 208, 231 ] }
in the first instance the procedure is condemned as too major an operative procedure , poorly tolerated by elderly patients .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 26, 35 ] }
{ "id": "C0543467", "name": "operative procedure", "pos": [ 65, 84 ] }
in the second , it is a poor procedure if it requires revision in a patient incapable of withstanding more than one operation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 29, 38 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 116, 125 ] }
in 61 patients with pituitary adenoma , plasma tsh responses to sulpiride were significantly greater than those of normal controls , and the mean maximal increments were as follows : 1.65 +/- 0.24 micro units/ml in acromegaly ( n = 21 ) , 2.63+/- 0.55 micro units/ml in non-functioning pituitary adenoma ( n = 23 ) , and...
nichd_parent_of
{ "id": "C0032000", "name": "pituitary adenoma", "pos": [ 20, 37 ] }
{ "id": "C0338078", "name": "non-functioning pituitary adenoma", "pos": [ 270, 303 ] }
in 61 patients with pituitary adenoma , plasma tsh responses to sulpiride were significantly greater than those of normal controls , and the mean maximal increments were as follows : 1.65 +/- 0.24 micro units/ml in acromegaly ( n = 21 ) , 2.63+/- 0.55 micro units/ml in non-functioning pituitary adenoma ( n = 23 ) , and...
nichd_parent_of
{ "id": "C0032000", "name": "pituitary adenoma", "pos": [ 20, 37 ] }
{ "id": "C0033375", "name": "prolactin producing pituitary adenoma", "pos": [ 353, 390 ] }
these results suggest that the dopaminergic inhibitory influence on tsh secretion is increased in patients with pituitary adenoma , and that it is especially dominant in patients with prolactin producing pituitary adenoma .
nichd_parent_of
{ "id": "C0032000", "name": "pituitary", "pos": [ 112, 121 ] }
{ "id": "C0033375", "name": "prolactin producing", "pos": [ 184, 203 ] }
the majority of tumor-bearing ( 63 % ) showed marked histiocytosis which was either diffuse or nodular involving primarily lymph nodes draining the site of the tumor .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 16, 21 ] }
{ "id": "C0019618", "name": "histiocytosis", "pos": [ 53, 66 ] }
comparison of intestinal arteriolar characteristics in vivo were made in normal rats , normal rats injected intraperitoneally twice daily with either 0.15 mmol/l saline or 16.6 mmol/l glucose in 0.15 mmol/l saline ( total value 5 % of body weight ) , and in streptozotocin treated rats ( plasma glucose greater than 22.2...
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 36, 51 ] }
{ "id": "C0005910", "name": "weight", "pos": [ 240, 246 ] }
after penetrating the human organism , these parasites never mature to adult worms but can produce a lot of various symptoms which are dependent on the kind of manifestation .
nichd_parent_of
{ "id": "C0029235", "name": "organism", "pos": [ 28, 36 ] }
{ "id": "C0030498", "name": "parasites", "pos": [ 45, 54 ] }
the liver appears to selectively trap heavily piliated organisms since reperfusion of bacteria through a second liver results in significantly less trapping than occurs with the first perfusion .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 55, 64 ] }
{ "id": "C0004611", "name": "bacteria", "pos": [ 86, 94 ] }
the tumor-host relationship is an essential factor in the onset , development , and recovery from malignancies .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 4, 9 ] }
{ "id": "C0006826", "name": "malignancies", "pos": [ 98, 110 ] }
both of the large groups , lateral and central facial skull fractures , are further divided into isolated fractures of particular localisations ( zygomatic arc , orbital floor fracture etc . ) and compound fractures of varying degrees ( lateral or central impression fractures of the mid-face grade i-iii ) .
nichd_parent_of
{ "id": "C0016658", "name": "fractures", "pos": [ 60, 69 ] }
{ "id": "C0016662", "name": "compound", "pos": [ 197, 205 ] }
in a collaborative study of 2 standard procedures ( procedure i , presented in j. assoc . off . anal . chem . 60 , 546-562 ( 1977 ) and procedure ii in the bacteriological analytical manual , 1978 ) , 7 laboratories evaluated the invasive potential of escherichia coli .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 39, 48 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 216, 225 ] }
the efficacy of doxepin compared with that of placebo was thus documented in several depressive and pain parameters , indicating that doxepin is a valuable treatment for patients with chronic pain and depression .
nichd_parent_of
{ "id": "C0030193", "name": "pain", "pos": [ 100, 104 ] }
{ "id": "C0150055", "name": "chronic pain", "pos": [ 184, 196 ] }
using a procedure that gave the greatest reproducibility , mssmet analyses of urinary steroids were evaluated with packed ( 3-m 3 % ov-101 ) and capillary ( 50-m ov-101 wcot fused silica ) columns .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 8, 17 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 100, 109 ] }
the techniques have been used to study changes in the biochemical composition of body fluids and tissues in different human diseases : metabolic disorder , neurological disorders and certain types of cancer .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 124, 132 ] }
{ "id": "C0027765", "name": "neurological disorders", "pos": [ 156, 178 ] }
the procedure described has been successfully applied to the investigation of the metabolic pattern of aminopyrine in rat plasma and cell incubation media .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 4, 13 ] }
{ "id": "C0220825", "name": "investigation", "pos": [ 61, 74 ] }
these changes can conveniently be placed into five broad categories : ( 1 ) physiologic changes in skin and appendages caused principally by the hormonal milieu , ( 2 ) cutaneous tumors affected by pregnancy , ( 3 ) diseases specifically associated with pregnancy , ( 4 ) genital infections of perinatal importance , and...
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 216, 224 ] }
{ "id": "C0037274", "name": "dermatologic diseases", "pos": [ 333, 354 ] }
infections were classified as by primary or secondary pathogens , depending on the importance of the isolated organism as a mastitis pathogen .
nichd_parent_of
{ "id": "C0029235", "name": "organism", "pos": [ 110, 118 ] }
{ "id": "C0450254", "name": "pathogen", "pos": [ 133, 141 ] }
however , few studies , regardless of level of success , have used an analytic procedure to identify those components of the evaluation system that , if refined further , could improve reliability .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 79, 88 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 125, 135 ] }
these procedures , combined with recent advances in anesthesia , may have reduced the occurrence of fatal cardiac arrests caused by the elicitation of the reflex during ocular surgery , however , for numerous reasons , the reflex remains of optometric interest .
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 6, 16 ] }
{ "id": "C0002903", "name": "anesthesia", "pos": [ 52, 62 ] }
the impressive and significant success rate for complete resolution of verrucous lesions without subsequent scarring has shown this approach to be an effective treatment for plantar warts .
nichd_parent_of
{ "id": "C0043037", "name": "verrucous", "pos": [ 71, 80 ] }
{ "id": "C0042548", "name": "plantar warts", "pos": [ 174, 187 ] }
studies carried out in foreign countries ( us and uk , mainly ) indicate that maternal characteristics , such as age , parity , social class , and prenatal care , are related to child 's growth , mortality , and morbidity , as well as to cigarette smoking .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 87, 102 ] }
{ "id": "C0030563", "name": "parity", "pos": [ 119, 125 ] }
the main conclusion from the coverage checks was that the census probably missed about 241,000 people net ( about half of one per cent of the population ) including some 36,000 children aged 0-4 .
nichd_parent_of
{ "id": "C0027361", "name": "people", "pos": [ 95, 101 ] }
{ "id": "C0008059", "name": "children", "pos": [ 177, 185 ] }
we conclude that the addition of dextrose to a crystalloid priming solution decreases intraoperative fluid requirements and helps restore precardiopulmonary bypass hemoglobin without the need for diuretics or blood products .
nichd_parent_of
{ "id": "C0005889", "name": "fluid", "pos": [ 101, 106 ] }
{ "id": "C0456388", "name": "blood products", "pos": [ 209, 223 ] }
the results of angioplasty were also studied in 36 children who underwent this procedure to treat coarctation of the aorta ( involving 21 native and 15 recurrent lesions ) .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 79, 88 ] }
{ "id": "C0087111", "name": "treat", "pos": [ 92, 97 ] }
for many years , the only available vaccine against a parasite in australia has been the attenuated babesia bovis vaccine produced by the tick fever research centre of the queensland department of primary industries .
nichd_parent_of
{ "id": "C0042210", "name": "vaccine", "pos": [ 36, 43 ] }
{ "id": "C0042211", "name": "attenuated", "pos": [ 89, 99 ] }
peak concentrations were 3 to 5-fold lower for the ip route in mice and the oral route in dogs , and the bioavailabilities were 85 % and 40 % , respectively .
nichd_parent_of
{ "id": "C0013153", "name": "route", "pos": [ 54, 59 ] }
{ "id": "C1527415", "name": "oral route", "pos": [ 76, 86 ] }
we investigated the dissociation by fluid phase hapten of igg antibodies bound to cell surface hapten in the presence and absence of anti-igg antibodies .
nichd_parent_of
{ "id": "C0005889", "name": "fluid", "pos": [ 36, 41 ] }
{ "id": "C0003241", "name": "antibodies", "pos": [ 142, 152 ] }
since such anti-edema drugs as 1,2-bis ( nicotinamido ) propane were proved to be potent suppressors of the enhanced atpase activity , further speculations on the role of this effect for ischemic brain edema are offered .
nichd_parent_of
{ "id": "C0013604", "name": "edema", "pos": [ 16, 21 ] }
{ "id": "C0006114", "name": "brain edema", "pos": [ 196, 207 ] }
the presence of a characteristic radiographic finding , the ring sequestrum , is virtually diagnostic of this abnormality .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 46, 53 ] }
{ "id": "C0011900", "name": "diagnostic", "pos": [ 91, 101 ] }
the imaging potential of mr and its noninvasive characteristics warrant priority for further examination of mr as a useful modality in the diagnosis of tmj pain and dysfunction .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 48, 63 ] }
{ "id": "C0695347", "name": "modality", "pos": [ 123, 131 ] }
patients that underwent this procedure were evaluated to identify the possible reasons for the double puncture .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 29, 38 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 44, 53 ] }
in contrast , significant positive relationships of cancer incidence with population density were found for all cancer , for cancer of the lung for both sexes , for stomach , colonic , and prostatic cancer for males , and for lymphomas , thyroid , breast , and ovarian cancer for females .
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 52, 58 ] }
{ "id": "C0024299", "name": "lymphomas", "pos": [ 226, 235 ] }
analysis of remission induction rates for 1,117 children 18 months to 10 years of age ( group 1 ) and 90 infants less than 18 months of age ( group 2 ) with acute lymphoid leukemia ( all ) and of duration of continuous complete remission ( ccr ) for 454 in group 1 and 33 in group 2 revealed that infants fared significa...
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 48, 56 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 297, 304 ] }
in the present study , we demonstrate an abnormal spectrin alpha subunit in two kindreds with hereditary elliptocytosis ( he ) that is qualitatively identical to hpp spectrin .
nichd_parent_of
{ "id": "C0013902", "name": "hereditary elliptocytosis", "pos": [ 94, 119 ] }
{ "id": "C0520739", "name": "hpp", "pos": [ 162, 165 ] }
clinical expression of he in these families ranges from mild elliptocytosis without hemolysis to severe poikilocytic hemolytic anemia clinically resembling hpp .
nichd_parent_of
{ "id": "C0013902", "name": "elliptocytosis", "pos": [ 61, 75 ] }
{ "id": "C0520739", "name": "hpp", "pos": [ 156, 159 ] }
thirty children acutely infected by plasmodium falciparum and suffering either benign uncomplicated malaria ( 17 cases ) , or cerebral malaria ( 13 cases ) , were investigated for t-cell number and subset distribution among peripheral blood mononuclear cells using okt3 , okt4 , and okt8 monoclonal antibodies , and for ...
nichd_parent_of
{ "id": "C0024530", "name": "malaria", "pos": [ 100, 107 ] }
{ "id": "C0024534", "name": "cerebral malaria", "pos": [ 126, 142 ] }
nk activity was found elevated in uncomplicated cases of malaria , in contrast to patients suffering cerebral malaria , who exhibited a profound depression of nk activity .
nichd_parent_of
{ "id": "C0024530", "name": "malaria", "pos": [ 57, 64 ] }
{ "id": "C0024534", "name": "cerebral", "pos": [ 101, 109 ] }
there were 19 brachial plexus injuries , 13 cases with cervical spondylopathic radiculopaties without myelopathy and 7 patients presented brachial plexopathy with systemic cancer .
nichd_parent_of
{ "id": "C0161446", "name": "brachial plexus injuries", "pos": [ 14, 38 ] }
{ "id": "C0700251", "name": "brachial plexopathy", "pos": [ 138, 157 ] }
the current results lend further support to our hypothesis that endogenous estrogens in the host , acting through the cytosol binding protein in the fungus , inhibit mycelial-to-yeast-form transformation , thus explaining the resistance of women to paracoccidioidomycosis .
nichd_parent_of
{ "id": "C0016832", "name": "fungus", "pos": [ 149, 155 ] }
{ "id": "C0043393", "name": "yeast-form", "pos": [ 178, 188 ] }
these studies in a mother and child describe the effects of multiple antibodies directed against the tsh receptor that influenced thyroid function in the fetus and infant .
nichd_parent_of
{ "id": "C0008059", "name": "child", "pos": [ 30, 35 ] }
{ "id": "C0021270", "name": "infant", "pos": [ 164, 170 ] }
it was observed that the slow atrial or junctional rhythms that appeared after intraatrial correction of transposition of the great arteries rarely progressed to life-threatening rhythm disorders in childhood or adolescence , but the prognosis in adult life remains unknown .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 199, 208 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 212, 223 ] }
thus , ejection fraction at rest has little discriminate value relative to the diagnosis of coronary artery disease , but does have value in evaluating the extent of disease in patients after myocardial infarction .
nichd_parent_of
{ "id": "C0018799", "name": "the", "pos": [ 75, 78 ] }
{ "id": "C0027051", "name": "myocardial infarction", "pos": [ 192, 213 ] }
the percentage of individuals bearing children was 75.7 % for ad versus 70.8 % for their normal siblings .
nichd_parent_of
{ "id": "C0027361", "name": "individuals", "pos": [ 18, 29 ] }
{ "id": "C0008059", "name": "children", "pos": [ 38, 46 ] }
consistent with this notion was the detection of ecp/ep-x in the fluid of phagocytic vacuoles containing amastigotes and associated with the ingested organisms at the same time as the parasites began to show structural alterations .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 150, 159 ] }
{ "id": "C0030498", "name": "parasites", "pos": [ 184, 193 ] }
three malignant tumors ( 3ll carcinoma , mfs6 sarcoma , and b16 f1 melanoma ) were transplanted in mice with congenital ( beige ) or acquired ( anti-asialo gm1-treated ) defects of natural killer cell ( nk ) activity .
nichd_parent_of
{ "id": "C0006826", "name": "malignant tumors", "pos": [ 6, 22 ] }
{ "id": "C1261473", "name": "sarcoma", "pos": [ 46, 53 ] }
these data suggest that nk cell-mediated resistance does not play an appreciable role in the regulation of the levels of tumor-associated macrophages in established malignancy .
nichd_parent_of
{ "id": "C0027651", "name": "tumor", "pos": [ 121, 126 ] }
{ "id": "C0006826", "name": "malignancy", "pos": [ 165, 175 ] }
to evaluate the patient who has had some asbestos exposure , the physician should focus on the pulmonary system , take a thorough occupational history , conduct a physical examination and pulmonary function studies , and obtain chest films .
nichd_parent_of
{ "id": "C0220825", "name": "evaluate", "pos": [ 3, 11 ] }
{ "id": "C0031809", "name": "physical", "pos": [ 163, 171 ] }
a focal neoplasm is a circumscribed mass less than 2 cm in diameter and without associated edema .
nichd_parent_of
{ "id": "C0027651", "name": "neoplasm", "pos": [ 8, 16 ] }
{ "id": "C0577559", "name": "a", "pos": [ 95, 96 ] }
we report 2 cases of this unusual and interesting condition , and review the embryogenesis of mullerian duct abnormalities associated with renal agenesis , as well as the clinical findings , diagnosis and management .
nichd_parent_of
{ "id": "C0037088", "name": "clinical", "pos": [ 171, 179 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 191, 200 ] }
the disease recurred more frequently ( 35.1 per cent ) in the 57 patients with no receptors in the tumor than in the 45 with at least 1 receptor ( 17.8 per cent ) .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 4, 11 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 99, 104 ] }
this finding suggests that prompt decompression of the brachial plexus following these injuries may reduce the amount of neurologic impairment and reduce the morbidity of these injuries .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 5, 12 ] }
{ "id": "C3263723", "name": "injuries", "pos": [ 177, 185 ] }
cancer risk factors were identified in individual patients with predisposing genetic and congenital disorders : neurofibromatosis ( brain tumor ) , hereditary immunodeficiency ( lymphoma ) , down 's syndrome ( leukemia ) , xy gonadal dysgenesis ( germ cell tumor ) , giant nevus ( melanoma ) , and meningocele ( sacral t...
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 0, 6 ] }
{ "id": "C0024299", "name": "lymphoma", "pos": [ 178, 186 ] }
cancer risk factors were identified in individual patients with predisposing genetic and congenital disorders : neurofibromatosis ( brain tumor ) , hereditary immunodeficiency ( lymphoma ) , down 's syndrome ( leukemia ) , xy gonadal dysgenesis ( germ cell tumor ) , giant nevus ( melanoma ) , and meningocele ( sacral t...
nichd_parent_of
{ "id": "C0006826", "name": "cancer", "pos": [ 0, 6 ] }
{ "id": "C0025202", "name": "melanoma", "pos": [ 281, 289 ] }
partial laryngectomy was the procedure utilized to treat 26 patients with either marked limitation of vocal cord motion or fixation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 29, 38 ] }
{ "id": "C0087111", "name": "treat", "pos": [ 51, 56 ] }
if an inhibitor is present , the procedure needs careful re-evaluation , but in general , surgical indications should be those of the general population and routine procedures should be followed .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 33, 42 ] }
{ "id": "C0543467", "name": "surgical", "pos": [ 90, 98 ] }
of these , 52 subjects had niddm , 10 had insulin-dependent diabetes mellitus ( iddm ) , and 80 were nondiabetics ( nd ) .
nichd_parent_of
{ "id": "C0011849", "name": "niddm", "pos": [ 27, 32 ] }
{ "id": "C0011854", "name": "insulin-dependent diabetes mellitus", "pos": [ 42, 77 ] }
the use of each characteristic to classify individuals by bp category may help clinicians to use cross-sectional data when deciding on the treatment of raised bp .
nichd_parent_of
{ "id": "C1521970", "name": "characteristic", "pos": [ 16, 30 ] }
{ "id": "C0005823", "name": "bp", "pos": [ 159, 161 ] }
further evidence has been provided by the recent discoveries of hpv structural proteins ( viral antigens ) and hpv type 11 dna in lesions of cin , and hpv 16 and 18 dna predominantly in invasive cervical carcinomas .
nichd_parent_of
{ "id": "C0021344", "name": "hpv", "pos": [ 64, 67 ] }
{ "id": "C0999806", "name": "hpv 16", "pos": [ 151, 157 ] }
ninety clinic outpatients were divided evenly into three groups according to headache type -- migraine , cluster , and mixed .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 77, 85 ] }
{ "id": "C0149931", "name": "migraine", "pos": [ 94, 102 ] }
computed tomography may be of value in the evaluation of fractures of long bones in those cases in which clinical examination and plain radiographs fail to give adequate information as to the status of healing .
nichd_parent_of
{ "id": "C0220825", "name": "evaluation", "pos": [ 43, 53 ] }
{ "id": "C0031809", "name": "clinical examination", "pos": [ 105, 125 ] }
the value of cerebrospinal fluid ( csf ) lactate and lactate dehydrogenase ( ld ) activity in the rapid diagnosis of meningitis was investigated in three groups of patients -- a 'no meningitis ' , an aseptic meningitis and a bacterial meningitis group .
nichd_parent_of
{ "id": "C0025289", "name": "meningitis", "pos": [ 117, 127 ] }
{ "id": "C0025290", "name": "aseptic meningitis", "pos": [ 200, 218 ] }
the value of cerebrospinal fluid ( csf ) lactate and lactate dehydrogenase ( ld ) activity in the rapid diagnosis of meningitis was investigated in three groups of patients -- a 'no meningitis ' , an aseptic meningitis and a bacterial meningitis group .
nichd_parent_of
{ "id": "C0025289", "name": "meningitis", "pos": [ 117, 127 ] }
{ "id": "C0085437", "name": "bacterial meningitis", "pos": [ 225, 245 ] }
therefore , future efforts must be directed at defining the natural history and infectivity of individuals showing evidence of htlv iii or lav infection and toward specific antiviral therapy for those with infection and a vaccine for those at high risk for htlv iii infection and , consequently , aids .
nichd_parent_of
{ "id": "C0009450", "name": "infection", "pos": [ 143, 152 ] }
{ "id": "C0019693", "name": "htlv iii infection", "pos": [ 257, 275 ] }
the gamut of disease identified included congenital anomalies , neoplasm , trauma , torsion , varicocele , hydrocele , epididymo-orchitis , epididymal cyst/spermatocele , and post-radiation fibrosis .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 13, 20 ] }
{ "id": "C0027651", "name": "neoplasm", "pos": [ 64, 72 ] }
the cardiac arrhythmia pilot study ( caps ) is a 10-center study sponsored by the national heart , lung , and blood institute to determine whether postinfarction ventricular arrhythmias can be satisfactorily reduced for 1 year after acute myocardial infarction .
nichd_parent_of
{ "id": "C0003811", "name": "cardiac arrhythmia", "pos": [ 4, 22 ] }
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 162, 185 ] }