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nicolas-favre 's disease , also called lymphogranuloma venereum , a venereally transmitted disease caused by chlamydia trachomatis , is usually presenting as an inguinal lymphadenopathy or an anorectal syndrome .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 17, 24 ] }
{ "id": "C0039082", "name": "syndrome", "pos": [ 202, 210 ] }
the prognosis even of severe lupus nephritis in childhood and adolescence has improved in recent years .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 48, 57 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 62, 73 ] }
measurements were made of birthweight , length , head circumference , and triceps skinfold at 10 days , and of weight , height , head circumference , and triceps at 5 years .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 40, 46 ] }
{ "id": "C0262499", "name": "head circumference", "pos": [ 129, 147 ] }
to examine the role of the noradrenergic system in anxiety disorders , 23 patients ( nine with generalized anxiety disorders and 14 with panic disorders ) were studied for four weeks with clonidine hydrochloride , a predominantly presynaptic noradrenergic agonist , and with placebo .
nichd_parent_of
{ "id": "C0003469", "name": "anxiety disorders", "pos": [ 51, 68 ] }
{ "id": "C0270549", "name": "generalized anxiety disorders", "pos": [ 95, 124 ] }
a high index of suspicion and careful attention to clinical findings were reliable for establishing the diagnosis and indicating the timing of myofascial decompression .
nichd_parent_of
{ "id": "C0037088", "name": "clinical findings", "pos": [ 51, 68 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 104, 113 ] }
the consumption of solid feed by the hematologically examined calves developed more quickly than in other gdr rearing farms due to the early ad libitum supply with this feed component and the composition of fluid feed with milk .
nichd_parent_of
{ "id": "C0005889", "name": "fluid", "pos": [ 207, 212 ] }
{ "id": "C0026131", "name": "milk", "pos": [ 223, 227 ] }
laser nephelometry is a suitable technique for the quantitative determination and differentiation of both lectins and glycoconjugates in the low-picomolar range .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 51, 63 ] }
{ "id": "C1514721", "name": "range", "pos": [ 155, 160 ] }
the implications of this finding for the assay of beta-galactosidase under physiological conditions for prenatal diagnosis are discussed .
nichd_parent_of
{ "id": "C0037088", "name": "finding", "pos": [ 25, 32 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 113, 122 ] }
of the 62 patients with organisms 39 ( 63 % ) had previously received an antibiotic appropriate to the sensitivity of the pathogen .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 24, 33 ] }
{ "id": "C0450254", "name": "pathogen", "pos": [ 122, 130 ] }
staph . aureus , str . pneumoniae and anaerobes were the organisms most frequently found in empyemata following pneumonia , whilst gram-negative enteric bacilli , the most frequently isolated organisms , were the predominant pathogens in postoperative cases .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 57, 66 ] }
{ "id": "C0450254", "name": "pathogens", "pos": [ 225, 234 ] }
furthermore , in details of the structure , the active sequence nucleosomes look almost exactly like the average yeast nucleosome in repeat length , in the length of dna associated with the core particle , in the amount and type of heterogeneity found within and between the oligomeric and monomeric repeat lengths of dna , in the occurrence of discrete spacer lengths including the characteristic five nucleotide increments ( i.e. , 5 , 15 , 25 , ... base pairs ) , and in the length of dna between yeast nucleosomes .
nichd_parent_of
{ "id": "C1521970", "name": "characteristic", "pos": [ 383, 397 ] }
{ "id": "C1444754", "name": "length", "pos": [ 478, 484 ] }
the inhibitory is presented in a number of body fluids including serum , breast milk , gastrointestinal washing , lung washings and bile .
nichd_parent_of
{ "id": "C0005889", "name": "body fluids", "pos": [ 43, 54 ] }
{ "id": "C0026131", "name": "breast milk", "pos": [ 73, 84 ] }
to ensure that the signal is representative of the particular substance to be measured and not a result of some other substance in the biological matrix , a range of analytical methods have been employed .
nichd_parent_of
{ "id": "C0439861", "name": "substance", "pos": [ 62, 71 ] }
{ "id": "C0005889", "name": "substance", "pos": [ 118, 127 ] }
these findings confirm that mechanically induced injury of the oral mucosa may cause ulceration in people susceptible to aphthous stomatitis .
nichd_parent_of
{ "id": "C0041582", "name": "ulceration", "pos": [ 85, 95 ] }
{ "id": "C0038363", "name": "aphthous stomatitis", "pos": [ 121, 140 ] }
objective responses were noted in 11 patients ( 37 % ) with the following malignancies : non-hodgkin 's lymphoma ( 4 ) , acute non-lymphoblastic leukemia ( 2 ) , chronic granulocytic leukemia in blast crisis ( 1 ) , carcinoma of the breast ( 3 ) , and small cell carcinoma of the lung ( 1 ) .
nichd_parent_of
{ "id": "C0006826", "name": "malignancies", "pos": [ 74, 86 ] }
{ "id": "C0678222", "name": "carcinoma of the breast", "pos": [ 216, 239 ] }
previous methods used for purifying bacteriophage particles , and also the procedures employed in the isolation and purification of the oligomers generated by the bacteriophage action , have been so modified as to provide a more direct route to the degradation products .
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 75, 85 ] }
{ "id": "C0013153", "name": "route", "pos": [ 236, 241 ] }
fragments from four human pituitary adenomas ( three pituitary prolactinomas ; one acth-secreting adenoma ) were transplanted into the pituitary fossa of total-body irradiated , hypophysectomized rats .
nichd_parent_of
{ "id": "C0032000", "name": "pituitary adenomas", "pos": [ 26, 44 ] }
{ "id": "C0033375", "name": "pituitary prolactinomas", "pos": [ 53, 76 ] }
fragments from four human pituitary adenomas ( three pituitary prolactinomas ; one acth-secreting adenoma ) were transplanted into the pituitary fossa of total-body irradiated , hypophysectomized rats .
nichd_parent_of
{ "id": "C0032000", "name": "pituitary adenomas", "pos": [ 26, 44 ] }
{ "id": "C1306214", "name": "acth-secreting adenoma", "pos": [ 83, 105 ] }
the dual approach utilizing dermatoglyphic and cytogenetic studies may aid in identifying persons with an enhanced risk for having children with down syndrome .
nichd_parent_of
{ "id": "C0027361", "name": "persons", "pos": [ 90, 97 ] }
{ "id": "C0008059", "name": "children", "pos": [ 131, 139 ] }
compared to normal children , pre-natally infected infants had significantly elevated igm concentrations throughout the first year of life and elevated iga levels for the first 6 months .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 19, 27 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 51, 58 ] }
sucrose density-gradient ultracentrifugation studies suggest that the mrf- and c1q-reactive substances in both bullous pemphigoid sera and blister fluids are of a size compatible with immune complexes .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 92, 102 ] }
{ "id": "C0005889", "name": "fluids", "pos": [ 147, 153 ] }
a t : b co-culture system was used to test for the presence of disordered immune homeostasis in the autoimmune disease , chronic idiopathic thrombocytopenic purpura ( itp ) .
nichd_parent_of
{ "id": "C0021053", "name": "disordered immune", "pos": [ 63, 80 ] }
{ "id": "C0004364", "name": "autoimmune disease", "pos": [ 100, 118 ] }
amongst patients with primary glomerulonephritis , higher levels were observed in minimal change nephropathy than in other types .
nichd_parent_of
{ "id": "C0017658", "name": "glomerulonephritis", "pos": [ 30, 48 ] }
{ "id": "C0027721", "name": "minimal change nephropathy", "pos": [ 82, 108 ] }
a mean ratio of 1.49 +/- 0.67 ( sd ) was obtained in the group of prepubertal children and infants greater than or equal to 2 mo of age .
nichd_parent_of
{ "id": "C0008059", "name": "children", "pos": [ 78, 86 ] }
{ "id": "C0021270", "name": "infants", "pos": [ 91, 98 ] }
all grades of ventricular arrhythmias were seen with occasional vebs in five patients , frequent in three , multifocal in four , coupled beats in two , and short runs of ventricular tachycardia in one patient .
nichd_parent_of
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 14, 37 ] }
{ "id": "C0042514", "name": "ventricular tachycardia", "pos": [ 170, 193 ] }
errors in external rotation are not always avoidable with this procedure , but they are tolerated with a lower surgical mortality than in the more complex method of osteosynthesis .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 63, 72 ] }
{ "id": "C0543467", "name": "surgical", "pos": [ 111, 119 ] }
in addition , data were available for nearly a 10-year span from houston , texas , as the monthly detections of the sexually transmitted diseases ( std ) of syphilis and gonorrhea .
nichd_parent_of
{ "id": "C0036916", "name": "sexually transmitted diseases", "pos": [ 116, 145 ] }
{ "id": "C0039128", "name": "syphilis", "pos": [ 157, 165 ] }
in addition , data were available for nearly a 10-year span from houston , texas , as the monthly detections of the sexually transmitted diseases ( std ) of syphilis and gonorrhea .
nichd_parent_of
{ "id": "C0036916", "name": "sexually transmitted diseases", "pos": [ 116, 145 ] }
{ "id": "C0018081", "name": "gonorrhea", "pos": [ 170, 179 ] }
the data on std ( 3,024 cases of primary syphilis and 179,064 cases of gonorrhea ) , when analyzed by cosinor analysis , also revealed circannual rhythmicity .
nichd_parent_of
{ "id": "C0036916", "name": "std", "pos": [ 12, 15 ] }
{ "id": "C0018081", "name": "gonorrhea", "pos": [ 71, 80 ] }
the procedure has proven to be safe and effective , creating a permanent biliary enteric fistula comparable to standard surgical procedures , but does not require a laparotomy/duodenotomy .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 4, 13 ] }
{ "id": "C0543467", "name": "surgical procedures", "pos": [ 120, 139 ] }
among diagnostic methods the radio-iodine test was reason for a wrong diagnosis most commonly ( 66 % ) .
nichd_parent_of
{ "id": "C0430022", "name": "diagnostic", "pos": [ 6, 16 ] }
{ "id": "C0022885", "name": "test", "pos": [ 42, 46 ] }
to determine whether receptor and/or postreceptor abnormalities of insulin action were responsible for insulin resistance in nonobese patients with non-insulin-dependent diabetes mellitus ( niddm ) and to assess the role of insulin resistance in their impaired glucose tolerance , insulin dose-response characteristics , insulin binding to monocytes , and insulin secretion were compared in 10 nonobese patients with niddm and six age-weight-matched nondiabetic volunteers .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 303, 318 ] }
{ "id": "C0005910", "name": "weight", "pos": [ 435, 441 ] }
analyses are made for somatic size and gain during infancy , childhood , adolescence , and the postnatal span from birth to early adulthood .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 61, 70 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 73, 84 ] }
the main substance of daycare seems to be behavioural , although a nursing- , paramedical or medical necessity must at least formally be present .
nichd_parent_of
{ "id": "C0004927", "name": "behavioural", "pos": [ 42, 53 ] }
{ "id": "C0006147", "name": "nursing", "pos": [ 67, 74 ] }
despite the fact that fewer lsh hamsters died when vsv was injected via the latter routes , the histopathology of the vsv-induced disease at early times after infection was identical irrespective of the route of virus administration .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 130, 137 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 159, 168 ] }
when goat anti-rd 114 p30 serum was used in the peroxidase-anti-peroxidase tissue staining procedure , p30-related antigen was detected in sections of all placental specimens ( early and term pregnancies , blighted ova , hydatidiform moles , destructive moles and choriocarcinomas ) .
nichd_parent_of
{ "id": "C0020217", "name": "hydatidiform moles", "pos": [ 221, 239 ] }
{ "id": "C0008493", "name": "destructive moles", "pos": [ 242, 259 ] }
a retrospective review of 143 patients with head or neck tumors who had received radiation therapy in the head and neck area for benign conditions during childhood or adolescence was conducted .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 154, 163 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 167, 178 ] }
the procedure is simple , shortens the duration of the operation and allows for both pre- and postoperative radiotherapy .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 4, 13 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 55, 64 ] }
the phadebact gonococcus test , a coagglutination procedure for the confirmation of identity of presumptive n gonorrhoeae isolates , was evaluated under normal working conditions in a routine diagnostic laboratory and compared with an immunofluorescence technique .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 50, 59 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 137, 146 ] }
all subjects were evaluated by history and physical examination , intradermal skin testing to the common aeroallergens , measurements of ige antibody to common aeroallergens with the rast , and serum ige levels .
nichd_parent_of
{ "id": "C0220825", "name": "evaluated", "pos": [ 18, 27 ] }
{ "id": "C0031809", "name": "physical examination", "pos": [ 43, 63 ] }
advantages of this procedure are ( 1 ) that it is quicker and easier to perform than a procedure requiring kirschner wires or plates , ( 2 ) no special equipment is needed , and ( 3 ) motion can often be started as early as 10 days after the operation .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 19, 28 ] }
{ "id": "C0543467", "name": "operation", "pos": [ 242, 251 ] }
these results suggest a potential role for mtf generation in the activation of blood coagulation in neoplasia and also suggest the possibility that inhibition of mtf generation by warfarin may be partially responsible for the decreased fpa values previously reported in anticoagulated cancer patients .
nichd_parent_of
{ "id": "C0027651", "name": "neoplasia", "pos": [ 100, 109 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 285, 291 ] }
even though virus did not replicate in ltk- cells , the presence of virus antigen could be observed by use of an anti-complement immunofluorescent technique at 4 h post-infection and the vzv-specific thymidine kinase could be detected in vzv-infected ltk- cells .
nichd_parent_of
{ "id": "C0042776", "name": "virus", "pos": [ 12, 17 ] }
{ "id": "C0042338", "name": "vzv", "pos": [ 238, 241 ] }
mean platelet monoamine oxidase activity was reduced compared with control values in groups of headache-free male ( but not female ) patients suffering from classical migraine and from tension headache .
nichd_parent_of
{ "id": "C0018681", "name": "headache", "pos": [ 95, 103 ] }
{ "id": "C0033893", "name": "tension headache", "pos": [ 185, 201 ] }
growth failure was common -- 57 % were below the third percentile in weight , 37 % in length , and 17 % in head circumference .
nichd_parent_of
{ "id": "C1444754", "name": "length", "pos": [ 86, 92 ] }
{ "id": "C0262499", "name": "head", "pos": [ 107, 111 ] }
the most common features of this illness are severe upper gastrointestinal symptoms ( abdominal pain , nausea , vomiting , hematemesis ) followed by the onset of generalized edema and ascites .
nichd_parent_of
{ "id": "C0042963", "name": "vomiting", "pos": [ 112, 120 ] }
{ "id": "C0018926", "name": "hematemesis", "pos": [ 123, 134 ] }
all of the methods of free t4 measurement in critical illness were nonspecific , and two of the methods failed to suggest hypothyroidism in two patients with primary hypothyroidism and another associated critical illness .
nichd_parent_of
{ "id": "C0020676", "name": "hypothyroidism", "pos": [ 122, 136 ] }
{ "id": "C0700502", "name": "primary hypothyroidism", "pos": [ 158, 180 ] }
the possible relationship between ganglioside levels and ganglioside profiles in malignant tumors and the formation of metastasis was investigated by the analysis of gangliosides in metastasizing smt-2a and nonmetastasizing mt-w9a mammary carcinomas as well as in metastases formed from smt-2a tumors .
nichd_parent_of
{ "id": "C0006826", "name": "malignant tumors", "pos": [ 81, 97 ] }
{ "id": "C0678222", "name": "mammary carcinomas", "pos": [ 231, 249 ] }
on the basis of the activities of the isoenzymes for the test persons ( children and adults of either sex ) an arrangement in the groups pathologic -- suspicious -- normal can be carried out which is compared with the physiologic parameters and the clinic .
nichd_parent_of
{ "id": "C0027361", "name": "persons", "pos": [ 62, 69 ] }
{ "id": "C0008059", "name": "children", "pos": [ 72, 80 ] }
in various other tumors remission was observed in soft tissue sarcomas ( 3/8 ) , thyroid cancer ( 1/7 ) , osteogenic sarcoma ( 1/4 ) , oesophageal cancer ( 2/4 ) , lung cancer ( 2/4 ) , bladder cancer ( 1/2 ) and hepatoma ( 1/2 ) .
nichd_parent_of
{ "id": "C1261473", "name": "soft tissue sarcomas", "pos": [ 50, 70 ] }
{ "id": "C0029463", "name": "osteogenic sarcoma", "pos": [ 106, 124 ] }
both cases were etiologically similar but located differently , so that two methods of surgically intervention were used .
nichd_parent_of
{ "id": "C0184661", "name": "methods", "pos": [ 76, 83 ] }
{ "id": "C0543467", "name": "surgically", "pos": [ 87, 97 ] }
the authors are considering pathogenesis of postoperative pancreatitis , discrepancy about the interpretation of the obtained laboratory parameters , the clinical finding and give a short description of the complication during postoperative pancreatitis , which actually has forced them for the surgical intervention .
nichd_parent_of
{ "id": "C0037088", "name": "clinical", "pos": [ 154, 162 ] }
{ "id": "C0009566", "name": "complication", "pos": [ 207, 219 ] }
a comparative study of uterine activity in labour induced with prostaglandin f2alpha or oxytocin and in spontaneous labour .
nichd_parent_of
{ "id": "C0022864", "name": "labour", "pos": [ 43, 49 ] }
{ "id": "C0474461", "name": "spontaneous labour", "pos": [ 104, 122 ] }
the lack of measurable cf antibodies in rf positive cases was apparently due to the inhibitory effect of rf ( s ) in the cf test .
nichd_parent_of
{ "id": "C0003241", "name": "antibodies", "pos": [ 26, 36 ] }
{ "id": "C0035448", "name": "rf", "pos": [ 105, 107 ] }
this procedure is virtually without complications and should , therefore , be done routinely in cases of abdominal neoplasms for evaluation of the operability , to confirm the angiographic findings indicating intravenous tumor invasion or extravenous compression , and as a primary examination in the assessment of possible or known abdominal tumors in children .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 5, 14 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 129, 139 ] }
to determine the relation between the sudden infant death syndrome ( sids ) and asymmetric septal hypertrophy ( ash ) , pathologic obervations weree made in 45 infants who died with sids .
nichd_parent_of
{ "id": "C0011065", "name": "died", "pos": [ 172, 176 ] }
{ "id": "C0038644", "name": "sids", "pos": [ 182, 186 ] }
several reflexes have the ability to produce apnea , in addition to the relatively common sleep apnea ;
nichd_parent_of
{ "id": "C0003578", "name": "apnea", "pos": [ 45, 50 ] }
{ "id": "C0037315", "name": "sleep apnea", "pos": [ 90, 101 ] }
recovery of cadmium from spiked filters was quantitative over a wide range of dilutions and for a variety of instrumental readout and calculation combinations .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 44, 56 ] }
{ "id": "C1514721", "name": "range", "pos": [ 69, 74 ] }
the patient with recurrent malignant ventricular arrhythmias ( ventricular fibrillation or ventricular tachycardia with syncope ) presents a complex therapeutic problem .
nichd_parent_of
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 37, 60 ] }
{ "id": "C0042510", "name": "ventricular", "pos": [ 91, 102 ] }
the patient with recurrent malignant ventricular arrhythmias ( ventricular fibrillation or ventricular tachycardia with syncope ) presents a complex therapeutic problem .
nichd_parent_of
{ "id": "C0085612", "name": "ventricular arrhythmias", "pos": [ 37, 60 ] }
{ "id": "C0042514", "name": "ventricular tachycardia", "pos": [ 91, 114 ] }
evaluations of maternal antropometric characteristics indicate that variations in birth weight and recumbent length of the newborn are affected more by maternal nutritional status than by maternal stature .
nichd_parent_of
{ "id": "C1521970", "name": "characteristics", "pos": [ 38, 53 ] }
{ "id": "C1444754", "name": "length", "pos": [ 109, 115 ] }
the paper describes the procedures and evaluation of a four-session introductory training program in behavior modification .
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 24, 34 ] }
{ "id": "C0220825", "name": "evaluation", "pos": [ 39, 49 ] }
( 2 ) a history of such behavioral symptoms as enuresis , encopresis , social apathy or inertia , defiant aggressiveness , sudden tantrums , crying spasms , insomnia , eccentric sleeping and waking schedule , pain agnosia , and self-injury , all occurring only in the growth-retarding environment ;
nichd_parent_of
{ "id": "C0004927", "name": "behavioral", "pos": [ 24, 34 ] }
{ "id": "C0037313", "name": "sleeping", "pos": [ 178, 186 ] }
five cases of neurological disorders occurring after extra-corporeal circulation are presented owing to the singular nature of the clinical picture made up by the essential element of a progressive brachial diplegia , free from any sensory disorder .
nichd_parent_of
{ "id": "C0027765", "name": "neurological disorders", "pos": [ 14, 36 ] }
{ "id": "C0221165", "name": "diplegia", "pos": [ 207, 215 ] }
in summary , idiopathic thrombocytopenic purpura ( as defined here ) should be treated initially with glucocorticoids unless there is life-threatening hemorrhage ( such as intracranial bleeding ) , in which case emergency splenectomy is indicated , since it generally gives the most prompt improvement in platelet count of all modes of the disease and to better define the cause of the thrombocytopenia .
nichd_parent_of
{ "id": "C0019080", "name": "hemorrhage", "pos": [ 151, 161 ] }
{ "id": "C0151699", "name": "intracranial bleeding", "pos": [ 172, 193 ] }
the prolongation of the disease-free interval in osteogenic sarcoma has permitted consideration of entirely new surgical approaches for this tumor in which radical amputation has traditionally been employed .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 24, 31 ] }
{ "id": "C0027651", "name": "tumor", "pos": [ 141, 146 ] }
the patterns of drug resistance and the frequency of conjugative r plasmids in intestinal escherichia coli from 88 patients treated for a skin disease ( acne vulgaris ) with low oral doses of tetracycline are reported .
nichd_parent_of
{ "id": "C0037274", "name": "skin disease", "pos": [ 138, 150 ] }
{ "id": "C0001144", "name": "acne", "pos": [ 153, 157 ] }
eight of 27 ( 30 % ) individual autistic children , 13 of 25 ( 52 % ) severely retarded children , two of 23 ( 9 % ) mildly retarded children , and none of the control children had statistically significant blood 5-ht levels elevations ( hyperserotonemia ) .
nichd_parent_of
{ "id": "C0027361", "name": "individual", "pos": [ 21, 31 ] }
{ "id": "C0008059", "name": "children", "pos": [ 168, 176 ] }
platelet monoamine oxidase ( mao ) activity was studied in 31 individuals suffering from early childhood autism and was not significantly different from that found in normal children or adults .
nichd_parent_of
{ "id": "C0027361", "name": "individuals", "pos": [ 62, 73 ] }
{ "id": "C0008059", "name": "children", "pos": [ 174, 182 ] }
the effects of method and time of fixation , staining , incubation time , and variations in procedures were evaluated .
nichd_parent_of
{ "id": "C0184661", "name": "procedures", "pos": [ 92, 102 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 108, 117 ] }
the localisation of lesions and the presence of changes in the placenta justify the conclusion that the disease developed , as a rule , as a result of hematogenic transplacental infection .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 104, 111 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 178, 187 ] }
whether an active accumulation of ototoxic substances or their metabolites occurs in the cochlea , or whether there exists a delayed elimination of these products from the endo-and perilymphatic fluids , following a passive equilibrium between the blood and the body tissues , is still a subject for discussion .
nichd_parent_of
{ "id": "C0439861", "name": "substances", "pos": [ 43, 53 ] }
{ "id": "C0005889", "name": "fluids", "pos": [ 195, 201 ] }
some diseases are more frequent in the latter half of life , while others -- such as the hereditary disorders -- are rare and occur only in a mild degree .
nichd_parent_of
{ "id": "C0012634", "name": "diseases", "pos": [ 5, 13 ] }
{ "id": "C0019247", "name": "hereditary disorders", "pos": [ 89, 109 ] }
diagnosis of blood disease is more difficult in the elderly because symptoms of anaemia such as weakness , shortness of breath and mental disorder are often attributed to old age .
nichd_parent_of
{ "id": "C0018939", "name": "diagnosis", "pos": [ 0, 9 ] }
{ "id": "C0002871", "name": "anaemia", "pos": [ 80, 87 ] }
the effect of the procedure on cardiac output was evaluated in a separate study of six subjects .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 18, 27 ] }
{ "id": "C0220825", "name": "evaluated", "pos": [ 50, 59 ] }
in order to investigate the combined effects of diabetes and hypertension on the pathogenesis of cardiovascular disease , adult male and female shr rats which develop hypertension spontaneously were given a single , 10 mg or 15 mg/100 g body wt . injection of alloxan s.c. to induce moderate or severe diabetes .
nichd_parent_of
{ "id": "C0007222", "name": "the", "pos": [ 24, 27 ] }
{ "id": "C0020538", "name": "hypertension", "pos": [ 167, 179 ] }
a quantitative enzyme analysis of 32 fetal human brains of 6 -- 42 weeks gestational age range was carried out for the major glycolytic and pentose phosphate shunt enzymes .
nichd_parent_of
{ "id": "C0392762", "name": "quantitative", "pos": [ 2, 14 ] }
{ "id": "C1514721", "name": "range", "pos": [ 89, 94 ] }
the relationship between chronic differences in sleep duration and waking behaviors was explored by comparing two groups of 10 healthy male university students who regularly slept nocturnally for 7-8 h or for 9.5-10.5 h .
nichd_parent_of
{ "id": "C0004927", "name": "behaviors", "pos": [ 74, 83 ] }
{ "id": "C0037313", "name": "slept", "pos": [ 174, 179 ] }
it was postulated that there were behavioral deficits in the control group attirbutable either to selective sleep stage deprivation or to the general consequence of reduced sleep per se or to both of these factors .
nichd_parent_of
{ "id": "C0004927", "name": "behavioral", "pos": [ 34, 44 ] }
{ "id": "C0037313", "name": "sleep", "pos": [ 173, 178 ] }
( d ) to help him consider whether his tendencies to misconstrue , and as a result to act misguidedly , can be understood by reference to the experiences he had with attachment figures during his childhood and adolescence , and perhaps may still be having .
nichd_parent_of
{ "id": "C0231335", "name": "childhood", "pos": [ 196, 205 ] }
{ "id": "C0001578", "name": "adolescence", "pos": [ 210, 221 ] }
[ familial asymmetrical septal hypertrophy with and without obstruction : clinical findings in patients with echocardiographically confirmed diagnosis ( author 's transl ) ] .
nichd_parent_of
{ "id": "C0037088", "name": "clinical", "pos": [ 74, 82 ] }
{ "id": "C0011900", "name": "diagnosis", "pos": [ 141, 150 ] }
this disorder is characterized by intermittent abdominal pains , neurological symptoms of central as well as peripheral genesis , and by psychotic syndromes .
nichd_parent_of
{ "id": "C0012634", "name": "disorder", "pos": [ 5, 13 ] }
{ "id": "C0039082", "name": "syndromes", "pos": [ 147, 156 ] }
antidepressants and pain : a review of the pharmacological data supporting the use of certain tricyclics in chronic pain .
nichd_parent_of
{ "id": "C0030193", "name": "pain", "pos": [ 20, 24 ] }
{ "id": "C0150055", "name": "chronic pain", "pos": [ 108, 120 ] }
from the close correlation between the statistical virus counts and the complement fixation titers for murine gs antigen of the tumors and their cultures , these viruses propagated in human cancer cells were confirmed to be infectious viruses of nude mouse origin .
nichd_parent_of
{ "id": "C0027651", "name": "tumors", "pos": [ 128, 134 ] }
{ "id": "C0006826", "name": "cancer", "pos": [ 190, 196 ] }
a case with an astrocytoma in the right basal ganglia , suspected of having originated from the posterior ventro-lateral part of the thalamus , without any clinical findings indicating severe internal hydrocephalus and cortical damaged , showed dissociation of sleep stages between the two hemispheres , i.e. , the affected side always fell earlier into deeper stages of sleep and was more difficult to arouse by sonic stimulations than the other side .
nichd_parent_of
{ "id": "C0037088", "name": "clinical findings", "pos": [ 156, 173 ] }
{ "id": "C0085639", "name": "fell", "pos": [ 336, 340 ] }
using two case-histories it is shown that atypical radiological findings caused the delay in diagnosis of pulmonary embolism depsite clinical signs ( such as fever and intermittent dyspnoea ; cyanosis , haemoptoe and cough reflex were absent ) .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 133, 147 ] }
{ "id": "C0015967", "name": "fever", "pos": [ 158, 163 ] }
using two case-histories it is shown that atypical radiological findings caused the delay in diagnosis of pulmonary embolism depsite clinical signs ( such as fever and intermittent dyspnoea ; cyanosis , haemoptoe and cough reflex were absent ) .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 133, 147 ] }
{ "id": "C0010520", "name": "cyanosis", "pos": [ 192, 200 ] }
since the presence of bactericidal , and not bacteriostatic , organisms has been associated with resistance to colonization of the throat by group a streptococci , this higher prevalence of bactericidal organisms in older individuals suggests that bacterial interference may be one of the mechanisms that account for the greater resistance of adults than children to streptococcal throat infection .
nichd_parent_of
{ "id": "C0027361", "name": "individuals", "pos": [ 222, 233 ] }
{ "id": "C0008059", "name": "children", "pos": [ 355, 363 ] }
this m. pulmonis-induced hydrocephalus may be a useful model for elucidating the pathogenesis of certain types of congenital hydrocephalus in humans .
nichd_parent_of
{ "id": "C0020255", "name": "hydrocephalus", "pos": [ 25, 38 ] }
{ "id": "C0020256", "name": "congenital hydrocephalus", "pos": [ 114, 138 ] }
these studies suggest that the cl procedure may be of value in the investigation of nonspecific opsonins in human serum .
nichd_parent_of
{ "id": "C0184661", "name": "procedure", "pos": [ 34, 43 ] }
{ "id": "C0220825", "name": "investigation", "pos": [ 67, 80 ] }
to characterize this resistance to gpic agent , we compared the disease and infection in previously infected guinea pigs with that in animals infected for the first time .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 64, 71 ] }
{ "id": "C0009450", "name": "infection", "pos": [ 76, 85 ] }
isolates of either corynebacterium diphtheriae or propionibacterium acnes from osteomyelitis are not necessarily contaminants , as shown by the cases of three patients who had bone and joint infections in which these organisms were pathogenic ( one in pure culture and two in mixed cultures ) .
nichd_parent_of
{ "id": "C0029235", "name": "organisms", "pos": [ 217, 226 ] }
{ "id": "C0450254", "name": "pathogenic", "pos": [ 232, 242 ] }
no evidence was found to support the view that cases of sids are subjected to chronic hypoxia before death as significantly more medial muscle tissue in the pulmonary arterioles and small arteries was found in the chronic hypoxic group compared to the sids , non-hypoxic , and acute hypoxic groups .
nichd_parent_of
{ "id": "C0011065", "name": "death", "pos": [ 101, 106 ] }
{ "id": "C0038644", "name": "sids", "pos": [ 252, 256 ] }
this investigation assessed the physical characteristics , functional capacities , and body composition of 45 professional fire fighters , aged 23 through 49 years .
nichd_parent_of
{ "id": "C0220825", "name": "investigation", "pos": [ 5, 18 ] }
{ "id": "C0031809", "name": "physical", "pos": [ 32, 40 ] }
numerous adverse effects including upper respiratory and gastrointestinal complaints , anemia , liver function abnormalities , and possibly aplastic anemia have been noted at tnt levels below the current standard of 1.5 mg/m3 .
nichd_parent_of
{ "id": "C0002871", "name": "anemia", "pos": [ 87, 93 ] }
{ "id": "C0002874", "name": "aplastic anemia", "pos": [ 140, 155 ] }
diplostomum spathaceum which is widespread throughout utah in desert , mountain valley , and high alpine lakes , causes a disease known as diplostomatosis or eye fluke disease .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 122, 129 ] }
{ "id": "C0015397", "name": "eye", "pos": [ 158, 161 ] }
as predicted from the spontaneous noise measurements , a low frequency impedance feature is observed between 1 and 30 hz which is voltage and temperature dependent , disappears after substantial reduction in [ ki+ ] , and is unaffected by the state of na+ conduction or active transport .
nichd_parent_of
{ "id": "C1521970", "name": "feature", "pos": [ 81, 88 ] }
{ "id": "C0039476", "name": "temperature", "pos": [ 142, 153 ] }
dosages of 20 and 10 ppm methylmercury were toxic to rabbits while 1 ppm did not produce clinical signs or death .
nichd_parent_of
{ "id": "C3540840", "name": "clinical signs", "pos": [ 89, 103 ] }
{ "id": "C0011065", "name": "death", "pos": [ 107, 112 ] }
no differences in wound healing were observed in pair-fed rats moved to a 30 degrees room postoperatively , among rats with or without fracture , nor among rats with femoral fracture given testosterone or saline subcutaneously .
nichd_parent_of
{ "id": "C0016658", "name": "fracture", "pos": [ 135, 143 ] }
{ "id": "C0015802", "name": "femoral fracture", "pos": [ 166, 182 ] }
nineteen patients had stage ii or iii disease at the time of initial examination , and only six had resectable tumors .
nichd_parent_of
{ "id": "C0012634", "name": "disease", "pos": [ 38, 45 ] }
{ "id": "C0027651", "name": "tumors", "pos": [ 111, 117 ] }