text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
in all three kinds of hypertensive rats the diuretic activity of ds-511 was similar to that of hc in the excretion of urine and sodium , but the former was less kaliuretic than the latter . | physiologic_effect_of | {
"id": "C2266870",
"name": "diuretic activity",
"pos": [
44,
61
]
} | {
"id": "C0020261",
"name": "hc",
"pos": [
95,
97
]
} |
the onset of bronchodilation after both fenoterol and isoproterenol was rapid , but the effect from fenoterol lasted much longer , up to eight hours . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
13,
28
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
54,
67
]
} |
the degree of the positive chronotropic effect of dob was the same as that of da . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
18,
39
]
} | {
"id": "C0012963",
"name": "dob",
"pos": [
50,
53
]
} |
the degree of the positive chronotropic effect of dob was the same as that of da . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
18,
39
]
} | {
"id": "C0013030",
"name": "da",
"pos": [
78,
80
]
} |
both the rate and the amount were reduced by the mitosis inhibitors colchicine , vinblastine , and griseofulvin . | physiologic_effect_of | {
"id": "C1371740",
"name": "reduced",
"pos": [
34,
41
]
} | {
"id": "C0042670",
"name": "vinblastine",
"pos": [
81,
92
]
} |
both the rate and the amount were reduced by the mitosis inhibitors colchicine , vinblastine , and griseofulvin . | physiologic_effect_of | {
"id": "C1371740",
"name": "reduced",
"pos": [
34,
41
]
} | {
"id": "C0018242",
"name": "griseofulvin",
"pos": [
99,
111
]
} |
the decreased concentrations of these amino and keto acids may be the result of decreased protein degradation or increased protein synthesis , possibly mediated by insulin . | physiologic_effect_of | {
"id": "C1372531",
"name": "increased",
"pos": [
113,
122
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
164,
171
]
} |
both isomers produced some bronchodilation , but the effect of pseudoephedrine was less than half that of ephedrine . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
27,
42
]
} | {
"id": "C0033798",
"name": "pseudoephedrine",
"pos": [
63,
78
]
} |
both isomers produced some bronchodilation , but the effect of pseudoephedrine was less than half that of ephedrine . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
27,
42
]
} | {
"id": "C0014479",
"name": "ephedrine",
"pos": [
106,
115
]
} |
positive chronotropic responses to tyramine were also reduced but those to noradrenaline and isoprenaline were increased suggesting that tyramine releasable stores of noradrenaline were reduced . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
0,
8
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
93,
105
]
} |
positive chronotropic responses to tyramine were also reduced but those to noradrenaline and isoprenaline were increased suggesting that tyramine releasable stores of noradrenaline were reduced . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
0,
8
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
167,
180
]
} |
the new compound antagonized the cardiovascular effects , such as positive chronotropic , positive inotropic , or depressor arterial blood pressure responses , elicited by intravenous isoproterenol ; | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
66,
87
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
184,
197
]
} |
using 10 isolated , blood-perfused canine atrial , and ventricular preparations , the effects of d- and l-verapamil on sa nodal pacemaker activity and contractility were investigated . l-verapamil and d-verapamil produced dose-related negative chronotropic and inotropic effects in all experiments . l-verapamil was approximately 10 time more potent than d-verapamil both in inotropism and chronotropism . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
235,
256
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
357,
366
]
} |
analysis of the distribution of s16 , l18 , and l32 r-protein mrnas in polysome gradients indicates that the increased translation of these mrnas in insulin-treated myoblasts is due to the recruitment of mrnas that were not previously being translated . | physiologic_effect_of | {
"id": "C1372531",
"name": "increased translation",
"pos": [
109,
130
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
149,
156
]
} |
effects of physostigmine and of beating rate on the negative chronotropic and inotropic responses to tonic intramural parasympathetic nerve stimulation at a frequency of 5 hz for 2 min were investigated , using the isolated , blood-perfused dog atrium which was pretreated with propranolol . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
52,
73
]
} | {
"id": "C0033497",
"name": "propranolol",
"pos": [
278,
289
]
} |
this short-term treatment modified neither the resting heart rate nor the positive chronotropic effect induced by either intravenous noradrenaline or electrical stimulation of pre- and post-ganglionic nerve fibres of the right stellate ganglion . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
74,
95
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
133,
146
]
} |
positive chronotropic effects of intravenously administered norepinephrine as well as tyramine were not altered during histamine infusion . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
0,
21
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
60,
74
]
} |
positive inotropy induced by ouabain , by increased frequency , by x537a ( ro2-2985 ) , by calcium and by isoproterenol : the lack of correlation with phosphorylation of tni . | physiologic_effect_of | {
"id": "C1372805",
"name": "positive inotropy",
"pos": [
0,
17
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
106,
119
]
} |
a 200-microgram inhaled dose of the rapidly metabolized agonist , isoproterenol , induced bronchodilation of the same order as terbutaline 500 microgram ( 1-sec forced expiratory volume [ fev1 ] increased 9.5 % and 10.2 % ) . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
90,
105
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
127,
138
]
} |
intravenously administered enprofylline produces bronchodilation comparable to theophylline in a mean dose ratio of 3.8 . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
49,
64
]
} | {
"id": "C0039771",
"name": "theophylline",
"pos": [
79,
91
]
} |
ovs obtained on day 10 suppressed basal fsh secretion by approximately 45 % and luteinizing hormone-releasing hormone stimulated luteinizing hormone secretion by approximately 50 % ( p less than 0.05 , versus castrate serum ) . | physiologic_effect_of | {
"id": "C1372328",
"name": "obtained",
"pos": [
4,
12
]
} | {
"id": "C0023610",
"name": "luteinizing hormone-releasing hormone",
"pos": [
80,
117
]
} |
in comparison , the isoproterenol test , performed in 10 of these patients , showed a similar sensitivity but prenalterol had a lower positive chronotropic effect than isoproterenol ( p less than 0.0005 ) . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
134,
155
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
168,
181
]
} |
the duration was longer with an increased bronchodilation ( p less than 0.01 ) 6 h after d2343 inhalation compared with terbutaline . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
42,
57
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
120,
131
]
} |
the positive inotropic effect of ta-064 was more pronounced than the positive chronotropic effect , compared with those of isoproterenol . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
69,
90
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
123,
136
]
} |
further , the inhibition of gastric acid secretion with cimetidine reduces somatostatin release during insulin-induced hypoglycaemia . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
14,
24
]
} | {
"id": "C0008783",
"name": "cimetidine",
"pos": [
56,
66
]
} |
direct administration of ym-09538 to isolated atria caused dose-dependent negative chronotropic and inotropic effects , and the potency was 3-30 times less than that of propranolol . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
74,
95
]
} | {
"id": "C0033497",
"name": "propranolol",
"pos": [
169,
180
]
} |
pretreatment with five terbutaline inhalations induced almost equal bronchodilation compared with theophyllamine but the following five inhalations now gave only about one-fourth of the effects recorded after theophyllamine pretreatment . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
68,
83
]
} | {
"id": "C0002575",
"name": "theophyllamine",
"pos": [
209,
223
]
} |
after 120 min , when steady-state bronchodilation was achieved , five terbutaline inhalations ( 1.25 mg terbutaline sulphate ) were added to both treatment regimens . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
34,
49
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
104,
115
]
} |
after 120 min , when steady-state bronchodilation was achieved , five terbutaline inhalations ( 1.25 mg terbutaline sulphate ) were added to both treatment regimens . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
34,
49
]
} | {
"id": "C0039543",
"name": "terbutaline sulphate",
"pos": [
104,
124
]
} |
the oral low-dose combination gave significantly better bronchodilation than the high dose of terbutaline alone and caused significantly less tremor . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
56,
71
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
94,
105
]
} |
when t3 ( 10 pg/min , 40 pg/min , 0.1 microgram/min , or 0.4 microgram/min ) was continuously infused into the sinus node artery , both positive chronotropic and inotropic actions of norepinephrine ( 0.03 microgram -- 0.3 microgram ) were not influenced . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
136,
157
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
183,
197
]
} |
while propranolol inhibited the bronchodilation and vasodilation responses to isoprenaline in the same dose range as it blocked the heart rate response , atenolol and metoprolol had to be given in considerably higher doses to block these effects . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
32,
47
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
78,
90
]
} |
cytoprotection by prostaglandins is unrelated to the inhibition of gastric acid secretion since , ( a ) it is maximal at doses that have no effect on gastric secretion , and ( b ) anti-secretory compounds ( cimetidine , methscopolamine bromide ) and antacids are not cytoprotective . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
53,
63
]
} | {
"id": "C0008783",
"name": "cimetidine",
"pos": [
207,
217
]
} |
cytoprotection by prostaglandins is unrelated to the inhibition of gastric acid secretion since , ( a ) it is maximal at doses that have no effect on gastric secretion , and ( b ) anti-secretory compounds ( cimetidine , methscopolamine bromide ) and antacids are not cytoprotective . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
53,
63
]
} | {
"id": "C0141756",
"name": "methscopolamine bromide",
"pos": [
220,
243
]
} |
yet there was no evidence of decreased phagocytosis with concentrations of colchicine as high as 2.5 x 10 ( -4 ) mole per l ( 100 mug per ml ) . | physiologic_effect_of | {
"id": "C1371834",
"name": "decreased",
"pos": [
29,
38
]
} | {
"id": "C0009262",
"name": "colchicine",
"pos": [
75,
85
]
} |
right atria isolated from implanted rats were hyporesponsive to the positive chronotropic effects of isoproterenol and glucagon but not to dibutyryl camp or to cac12 . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
68,
89
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
101,
114
]
} |
right atria isolated from implanted rats were hyporesponsive to the positive chronotropic effects of isoproterenol and glucagon but not to dibutyryl camp or to cac12 . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
68,
89
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
119,
127
]
} |
buflomedil ( 10 mg/kg i.v . ) reduced pressor responses to norepinephrine ( noradrenaline ) and enhanced depressor responses to isoprenaline ( isoproterenol ) , without affecting depressor responses to acetylcholine and positive chronotropic responses to norepinephrine and isoprenaline . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
220,
241
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
274,
286
]
} |
although a significant linear regression was obtained between metabolic rate and heart rate , a low overall correlation coefficient may result from the existence of separate individual regressions and confounding changes in stroke volume and/or arteriovenous oxygen difference . | physiologic_effect_of | {
"id": "C1372398",
"name": "obtained",
"pos": [
45,
53
]
} | {
"id": "C0030054",
"name": "oxygen",
"pos": [
259,
265
]
} |
specifically , histamine h1-antagonists known to produce more central nervous system stimulation in humans share discriminative stimulus properties with amph and/or produce observable signs of stimulation in monkeys . | physiologic_effect_of | {
"id": "C2917138",
"name": "central nervous system stimulation",
"pos": [
62,
96
]
} | {
"id": "C0002658",
"name": "amph",
"pos": [
153,
157
]
} |
this was done by measuring the inhibition of the positive chronotropic response to 10 ( -6 ) m isoproterenol before and after treatment with the drug . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
49,
70
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
95,
108
]
} |
in comparable beta-receptor blocking doses lb46 did not show the negative chronotropic property possessed by propranolol . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
65,
86
]
} | {
"id": "C0033497",
"name": "propranolol",
"pos": [
109,
120
]
} |
the positive chronotropic action produced by acetylcholine was blocked by dichloro-isopropylnoradrenaline and pronethalol and potentiated by cocaine.5 . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0022245",
"name": "isopropylnoradrenaline",
"pos": [
83,
105
]
} |
the rank order of alpha-adrenoceptor agonists to produce positive chronotropic responses was adrenaline greater than noradrenaline greater than phenylephrine greater than methoxamine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
57,
78
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
120,
130
]
} |
the rank order of alpha-adrenoceptor agonists to produce positive chronotropic responses was adrenaline greater than noradrenaline greater than phenylephrine greater than methoxamine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
57,
78
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
117,
130
]
} |
in part , this appears to be related to the cardioinhibitory and negative chronotropic action of verapamil , but it is also likely to depend on increases in bioavailability of prazosin and higher plasma levels when the drug is given with verapamil . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
65,
86
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
238,
247
]
} |
a marked positive chronotropic stimulation maintained a sufficient cardiac index and a normal blood pressure in spite of a profound vasodilatation which was unresponsive to dopamine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
9,
30
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
173,
181
]
} |
bronchodilation in fev1 was significantly greater than placebo for both active drugs : two hours on albuterol and five hours on fenoterol . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
0,
15
]
} | {
"id": "C0001927",
"name": "albuterol",
"pos": [
100,
109
]
} |
the effects of selective lesioning of brain serotonin or catecholamine containing neurones on the anorectic activity of fenfluramine and amphetamine . | physiologic_effect_of | {
"id": "C2825056",
"name": "anorectic activity",
"pos": [
98,
116
]
} | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
120,
132
]
} |
influence of the extracellular ca ++ concentration on the positive chronotropic action of adrenaline in the isolated atria of newborn and adult guinea-pigs . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
58,
79
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
90,
100
]
} |
increased antibody formation in human subjects inoculated with influenza virus vaccine in a water in-oil emulsion . | physiologic_effect_of | {
"id": "C1372092",
"name": "increased",
"pos": [
0,
9
]
} | {
"id": "C0021403",
"name": "influenza virus vaccine",
"pos": [
63,
86
]
} |
further it was observed that propranolol with magnesium became more effective in blocking the positive chronotropic and inotropic responses to isoprenaline . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
94,
115
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
143,
155
]
} |
three adrenergic responses , i. e. noradrenaline calorigenic effect , positive isoproterenol chronotropic action and seminiferous duct contraction after noradrenaline use was studied in experimental albino male rats . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
70,
78
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
79,
92
]
} |
three adrenergic responses , i. e. noradrenaline calorigenic effect , positive isoproterenol chronotropic action and seminiferous duct contraction after noradrenaline use was studied in experimental albino male rats . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
70,
78
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
153,
166
]
} |
it was shown that hyperthyroidism provokes intensification of the beta-adrenergic responses examined ( noradrenaline calorigenic effect and positive isoproterenol chronotropic effect ) ; | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
140,
148
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
149,
162
]
} |
the results suggest that the erucic acid-induced lipidosis is prevented or eliminated by increased lipolysis and oxidation of fatty acids when such a diet is supplemented with carnitine and/or fish oil . | physiologic_effect_of | {
"id": "C1372379",
"name": "increased lipolysis",
"pos": [
89,
108
]
} | {
"id": "C0016157",
"name": "fish oil",
"pos": [
193,
201
]
} |
during hyperventilation , the cerebral perfusion pressure became elevated , and increases in cmro2 were often found , even in patients with severe diffuse spasm and cerebral ischemia . | physiologic_effect_of | {
"id": "C1372398",
"name": "increases",
"pos": [
80,
89
]
} | {
"id": "C0030054",
"name": "cmro2",
"pos": [
93,
98
]
} |
in the present study , the effects of adenosine and related compounds were observed on the concentration-effect curve for the positive chronotropic effect of norepinephrine in isolated spontaneously beating rat atria . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
126,
147
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
158,
172
]
} |
mean maximum percent increase in fev1 and median duration of bronchodilation were greater with bitolterol than with albuterol , but the differences were not statistically significant . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
61,
76
]
} | {
"id": "C0001927",
"name": "albuterol",
"pos": [
116,
125
]
} |
7 it is concluded that both the positive inotropic and the positive chronotropic responses to dopamine are mediated partially by a direct and partially by an indirect stimulant effect on beta-adrenoceptors in the dog heart . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
59,
80
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
94,
102
]
} |
in moderate hypothermia we observed : i ) larger duration of the positive chronotropic response to isoprenaline with a delayed and slightly lesser intensity in its maximum ; | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
65,
86
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
99,
111
]
} |
furthermore , the negative chronotropic effect of both verapamil and nifedipine was enhanced at high calcium levels . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
18,
39
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
55,
64
]
} |
the negative chronotropic action of amiodarone was significantly enhanced when amiodarone was administered in a perfusate containing low ( 0.6 mm ) instead of normal calcium . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0002598",
"name": "amiodarone",
"pos": [
79,
89
]
} |
a continuous infusion of 100 micrograms/min of amiodarone significantly suppressed the positive chronotropic effect of norepinephrine whether expressed in percent change or in absolute values ; | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
87,
108
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
119,
133
]
} |
bronchodilation following nabilone was intermediate between that of terbutaline and placebo in the healthy subjects but was equivalent to placebo in the asthmatics . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
0,
15
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
68,
79
]
} |
the beta 2-selective agonist terbutaline , eg , causes bronchodilation with less beta 1-cardiac excitation than does the beta 1-beta 2 nonselective agonist isoproterenol . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
55,
70
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
156,
169
]
} |
after oral administration to conscious heidenhain pouch dogs , ed50 values for the inhibition of near maximal gastric acid secretion stimulated by histamine were 7.1 , 5.4 , 0.74 and 0.69 mumol/kg for cimetidine , etintidine , ranitidine and tiotidine , respectively . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
83,
93
]
} | {
"id": "C0008783",
"name": "cimetidine",
"pos": [
201,
211
]
} |
after oral administration to conscious heidenhain pouch dogs , ed50 values for the inhibition of near maximal gastric acid secretion stimulated by histamine were 7.1 , 5.4 , 0.74 and 0.69 mumol/kg for cimetidine , etintidine , ranitidine and tiotidine , respectively . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
83,
93
]
} | {
"id": "C0034665",
"name": "ranitidine",
"pos": [
227,
237
]
} |
the sinus node is significantly more sensitive to the negative chronotropic action of verapamil than is the av junctional pacemaker , and this differential responsiveness appears to be related to the different intrinsic rates of the two pacemakers . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
54,
75
]
} | {
"id": "C0042523",
"name": "verapamil",
"pos": [
86,
95
]
} |
the fev1 mean values showed a mild bronchodilation 15 min after salbutamol ( +13.2 % , p less than 0.006 ) and procaterol ( +8 % , ns ) . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
35,
50
]
} | {
"id": "C0001927",
"name": "salbutamol",
"pos": [
64,
74
]
} |
the negative chronotropic responses to vagus stimulation were unaffected by noradrenaline ( 1.0 mumol/l ) in the presence of propranolol ( 1.0 mumol/l ) . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0033497",
"name": "propranolol",
"pos": [
125,
136
]
} |
we studied the effect of concomitant administration of chlordiazepoxide on the negative chronotropic effect of metoprolol in rabbits . | physiologic_effect_of | {
"id": "C1372752",
"name": "negative chronotropic",
"pos": [
79,
100
]
} | {
"id": "C0025859",
"name": "metoprolol",
"pos": [
111,
121
]
} |
methoxamine exerted positive inotropy of left atria and papillary muscles , the maxima being 43.2 +/- 2.7 and 26.8 +/- 4.4 % of the isoprenaline maxima . | physiologic_effect_of | {
"id": "C1372805",
"name": "positive inotropy",
"pos": [
20,
37
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
132,
144
]
} |
this was done in basal condition , after methacholine-induced bronchoconstriction and after bronchodilation by either salbutamol or oxytropium bromide inhalation . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
92,
107
]
} | {
"id": "C0001927",
"name": "salbutamol",
"pos": [
118,
128
]
} |
reversal of anticoagulation with protamine sulfate causes many adverse haemodynamic and haematologic effects which could be due to differences in the mechanism of action of standard and low molecular weight heparin . | physiologic_effect_of | {
"id": "C2917126",
"name": "reversal",
"pos": [
0,
8
]
} | {
"id": "C0033602",
"name": "protamine sulfate",
"pos": [
33,
50
]
} |
positive chronotropic actions of isoproterenol were prevented by decreasing the calcium level below 1.84 mm . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
0,
8
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
33,
46
]
} |
however , these positive effects were not suppressed by either imipramine or tetrodotoxin , although imipramine inhibited tyramine-induced actions and tetrodotoxin suppressed acetylcholine-induced positive chronotropic and inotropic effects in atropine-treated preparations . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
197,
218
]
} | {
"id": "C0004259",
"name": "atropine",
"pos": [
244,
252
]
} |
carteolol has little adrenergic beta-receptor stimulating effect in doses which block prominent positive chronotropic and inotropic effects of norepinephrine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
96,
117
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
143,
157
]
} |
moreover , dda antagonized the adenylate cyclase mediated flow response due to the pgi2 analogue , iloprost , as well as the positive chronotropic and inotropic actions of isoproterenol . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
125,
146
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
172,
185
]
} |
bronchodilation and side effects of 28 days treatment with either a full therapeutic dose of theophylline slow-release preparation 500 mg twice daily ( 400-600 mg ) , a slow-release terbutaline preparation 10 mg twice daily or combinations of the 2 drugs in full or half doses were evaluated in 31 asthmatic outpatients in a double-blind , randomized crossover design . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
0,
15
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
182,
193
]
} |
metaproterenol produced a greater degree of bronchodilation than albuterol and terbutaline 30 minutes after drug dosing . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
44,
59
]
} | {
"id": "C0001927",
"name": "albuterol",
"pos": [
65,
74
]
} |
metaproterenol produced a greater degree of bronchodilation than albuterol and terbutaline 30 minutes after drug dosing . | physiologic_effect_of | {
"id": "C1371299",
"name": "bronchodilation",
"pos": [
44,
59
]
} | {
"id": "C0039542",
"name": "terbutaline",
"pos": [
79,
90
]
} |
the increased gluconeogenesis in response to glucagon was correlated with a decreased pyruvate kinase flux and lactate output ; | physiologic_effect_of | {
"id": "C1372342",
"name": "increased gluconeogenesis",
"pos": [
4,
29
]
} | {
"id": "C0017687",
"name": "glucagon",
"pos": [
45,
53
]
} |
in both models of arf the atrial positive chronotropic responses to isoprenaline were significantly decreased whilst positive inotropic responses were not significantly different from controls . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
33,
54
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
68,
80
]
} |
pia ( 1 microm ) was as effective as 1 nm insulin in reducing lipolysis stimulated by 1 nm isoproterenol and more effective than insulin at higher isoproterenol concentrations . | physiologic_effect_of | {
"id": "C1371696",
"name": "reducing lipolysis",
"pos": [
53,
71
]
} | {
"id": "C0021641",
"name": "insulin",
"pos": [
129,
136
]
} |
in normal man , increases in the regional cerebral metabolic rate for oxygen leads to proportional increases in the rcbf ( 34 ) . | physiologic_effect_of | {
"id": "C1372398",
"name": "increases",
"pos": [
16,
25
]
} | {
"id": "C0030054",
"name": "oxygen",
"pos": [
70,
76
]
} |
parallel changes were found in the anorectic activity of metachlorophenylpiperazine ( m-cpp ) , a potent central 5ht agonist : chronic treatment with d-fenfluramine or metergoline caused respectively a decrease and in the effect of m-cpp on food intake . | physiologic_effect_of | {
"id": "C2825056",
"name": "anorectic activity",
"pos": [
35,
53
]
} | {
"id": "C0015827",
"name": "fenfluramine",
"pos": [
152,
164
]
} |
inhibition of gastric acid secretion by the combined use of cimetidine and pirenzepin has been studied in 5 cases of zollinger-ellison syndrome . | physiologic_effect_of | {
"id": "C1372721",
"name": "inhibition",
"pos": [
0,
10
]
} | {
"id": "C0008783",
"name": "cimetidine",
"pos": [
60,
70
]
} |
furthermore , mianserin reduced the pressor response to adrenaline.3 desipramine , maprotiline and mianserin , but not phentolamine enhanced the positive chronotropic effects of noradrenaline , without affecting those of isoprenaline.4 all four compounds abolished the clonidine-induced inhibition of heart rate responses to short term electrical stimulation of the spinal cord . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
145,
166
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
178,
191
]
} |
furthermore , mianserin reduced the pressor response to adrenaline.3 desipramine , maprotiline and mianserin , but not phentolamine enhanced the positive chronotropic effects of noradrenaline , without affecting those of isoprenaline.4 all four compounds abolished the clonidine-induced inhibition of heart rate responses to short term electrical stimulation of the spinal cord . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
145,
166
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
221,
233
]
} |
neither drug reduced the pressor or positive chronotropic responses to catecholamines ( epinephrine , phenylphrine , isoproterenol ) , however . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
36,
57
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
88,
99
]
} |
neither drug reduced the pressor or positive chronotropic responses to catecholamines ( epinephrine , phenylphrine , isoproterenol ) , however . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
36,
57
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
117,
130
]
} |
in fact , at some doses pa and napa accentuated the pressor and positive chronotropic effects of epinephrine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
64,
85
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
97,
108
]
} |
the degree of shift was five-fold ( positive chronotropic response ) and 20-fold ( decrease in diastolic blood pressure ) in the oxyfedrine group and 10- and 80-fold , respectively , in the propranolol group.4 in contrast to the partial blockade of the effects of isoprenaline , the haemodynamic response to oxyfedrine was largely unaltered , both in the cats pretreated with propranolol and in those pretreated with oxyfedrine . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
36,
57
]
} | {
"id": "C0022245",
"name": "isoprenaline",
"pos": [
264,
276
]
} |
hexamethonium inhibited dmpp , but affected neither sns per se nor the facilitatory effects of mcn-a-343 and ahr 602 on sns.4 mcn-a-343 , cocaine and desipramine ( but not ahr 602 or hexamethonium ) blocked the net cardiac noradrenaline uptake and increased the positive chronotropic effect of noradrenaline.5 prior perfusion with concentrations of cocaine and desipramine sufficient to block uptake reduced or abolished the facilitatory effects of both mcn-a-343 and ahr 602 on sns.6 cocaine , mcn-a-343 and ahr 602 displayed local anaesthetic properties on the guinea-pig wheal and frog nerve plexus tests , and their relative potencies in this respect were similar to those for inhibition of dmpp-evoked transmitter overflow . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
262,
283
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
294,
307
]
} |
calcium and ouabain acted synergistically.5 increasing calcium concentrations inhibited the positive chronotropic effect of noradrenaline in a manner similar to increasing ouabain concentrations.6 a hypothesis is proposed which explains the chronotropic effect of ouabain on the basis of two mechanisms : ( 1 ) increase of the catecholamine concentration affecting the pacemaker ; | physiologic_effect_of | {
"id": "C1372804",
"name": "positive",
"pos": [
92,
100
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
124,
137
]
} |
the positive chronotropic and inotropic effects of dobutamine and salbutamol and the flow-decreasing effect of phenylephrine were not influenced by endotoxin pretreatment . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0012963",
"name": "dobutamine",
"pos": [
51,
61
]
} |
in addition , the pa2 values of bunitrolol as an antagonist against the positive chronotropic and inotropic actions ( beta 1-adrenoceptor ) of isoproterenol were also determined by pharmacological methods using the isolated guinea pig atria . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
72,
93
]
} | {
"id": "C0022245",
"name": "isoproterenol",
"pos": [
143,
156
]
} |
the positive chronotropic responses to adrenaline ( 3-10 micrograms/kg ) , noradrenaline ( 3-10 micrograms/kg ) and phenylephrine ( 30-100 micrograms/kg ) produced by activating alpha 1-adrenoreceptors had a slower time course than did the chronotropic responses produced by activation of beta-adrenoreceptors . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0014563",
"name": "adrenaline",
"pos": [
78,
88
]
} |
the positive chronotropic responses to adrenaline ( 3-10 micrograms/kg ) , noradrenaline ( 3-10 micrograms/kg ) and phenylephrine ( 30-100 micrograms/kg ) produced by activating alpha 1-adrenoreceptors had a slower time course than did the chronotropic responses produced by activation of beta-adrenoreceptors . | physiologic_effect_of | {
"id": "C1372804",
"name": "positive chronotropic",
"pos": [
4,
25
]
} | {
"id": "C0028351",
"name": "noradrenaline",
"pos": [
75,
88
]
} |
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