text stringlengths 57 1.72k | relation stringclasses 125
values | h dict | t dict |
|---|---|---|---|
the results of the study illustrate that artery pg of the pigeon are similar in distribution to those described for the human aorta and contain at least three types of pg , a chondroitin sulfate pg , a dermatan sulfate pg , and a polydisperse heparan sulfate pg . | NA | {
"id": "C0033692",
"name": "pg",
"pos": [
48,
50
]
} | {
"id": "C0033689",
"name": "chondroitin sulfate pg",
"pos": [
175,
197
]
} |
the phage t4 dna polymerase catalyzes dna synthesis at this preformed replication fork in the presence of gene 4 protein , but the amount of dna synthesized is less that 3 % of the amount synthesized by the combination of form ii of t7 dna polymerase and gene 4 protein . | NA | {
"id": "C0012892",
"name": "dna polymerase",
"pos": [
13,
27
]
} | {
"id": "C0012889",
"name": "ii",
"pos": [
227,
229
]
} |
tetraribonucleotides ( pppaccc or pppacca ) , synthesized by the t7 gene 4 protein on single-stranded dna , are used as primers by t7 dna polymerase to yield rna-terminated dna fragments . | NA | {
"id": "C0012935",
"name": "single-stranded dna",
"pos": [
86,
105
]
} | {
"id": "C0012854",
"name": "dna",
"pos": [
173,
176
]
} |
antibodies specific for the synthetic peptide were purified from immune sera by affinity chromatography on peptide-bound sepharose and characterized by a number of immunocytochemical techniques . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "immune sera",
"pos": [
65,
76
]
} |
the capacity of the liver microsomal mixed function oxidase system to metabolize a great variety of exogenous as well as endogenous compounds is thought to reflect the participation of multiple forms of the terminal oxidase , cytochrome p-450 , which have different broad , but overlapping , substrate specificities . | NA | {
"id": "C0003927",
"name": "microsomal mixed function oxidase",
"pos": [
26,
59
]
} | {
"id": "C0010762",
"name": "cytochrome",
"pos": [
226,
236
]
} |
they are analogous to data obtained for transducin , the gtp-binding regulatory protein from vertebrate rod outer segment discs , and for the putative inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase ( the substrate for islet-activating protein ) . | NA | {
"id": "C0018353",
"name": "gtp",
"pos": [
57,
60
]
} | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
162,
180
]
} |
rabbit antisera to different a. fumigatus antigen preparations varied in their reactivity in crossed immunoelectrophoresis tests , but line immunoelectrophoresis indicated that all the antisera contained the same qualitative antibody components to the fungus . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
7,
15
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
225,
233
]
} |
and ( 4 ) inverse qualitative distribution of the glycosaminoglycans , i.e. , decrease of heparan sulfate and chondroitin-6-sulfate and increase of hyaluronic acid and dermatan sulfate . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
50,
68
]
} | {
"id": "C0019143",
"name": "heparan sulfate",
"pos": [
90,
105
]
} |
sixty-four per cent of the fractures were segmental and 36 per cent were transverse with comminution . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
27,
36
]
} | {
"id": "C0476171",
"name": "comminution",
"pos": [
89,
100
]
} |
using radiolabeling with h2 35so4 , it is shown that peripheral blood mononuclear cells ( pbmc ) and their major subpopulations ( b cells , t cells , and monocytes ) , as well as mouse spleen cells , all secreted easily detectable proteoglycan . | NA | {
"id": "C1321301",
"name": "peripheral",
"pos": [
53,
63
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
192,
197
]
} |
the e2 protein ( 422 amino acid residues long ) of semliki forest virus is a spanning membrane protein which is made in the rough endoplasmic reticulum of the infected cell and transported to the cell surface . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
7,
14
]
} | {
"id": "C0025252",
"name": "membrane protein",
"pos": [
86,
102
]
} |
we introduced deletions of various sizes into the gene region encoding this part of the protein molecule and analyzed the transport behavior of the mutant proteins . | NA | {
"id": "C0033684",
"name": "protein",
"pos": [
88,
95
]
} | {
"id": "C0007292",
"name": "transport",
"pos": [
122,
131
]
} |
the recent discovery and characterization of several proteins that purify with endogenous , bound retinoid have given rise to the suggestion that these proteins , which are abundant in retina , perform a role in transport and function of vitamin a . | NA | {
"id": "C0035339",
"name": "retinoid",
"pos": [
98,
106
]
} | {
"id": "C0042839",
"name": "vitamin a",
"pos": [
238,
247
]
} |
antibodies from each antiserum reacted with a single component in retinal homogenates and supernatants which corresponded to the molecular weight and charge of the respective antigen ( non-sds and sds page , electrophoretic transfer to nitrocellulose , immunochemical staining ) . | NA | {
"id": "C0003241",
"name": "antibodies",
"pos": [
0,
10
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
21,
30
]
} |
modulators or analogues of cyclic nucleotides did not influence epidermal differentiation , and cyclic nucleotide levels did not change significantly in the first 10 min after increasing calcium . | NA | {
"id": "C0028631",
"name": "cyclic nucleotides",
"pos": [
27,
45
]
} | {
"id": "C0028630",
"name": "nucleotide",
"pos": [
103,
113
]
} |
cm-sm is a clonal line of human precursor mononuclear phagocytes inducible to macrophage differentiation in response to the tumor promoter phorbol ester 12-o-tetradecanoyl-phorbol-13-acetate ( tpa ) . | NA | {
"id": "C0031586",
"name": "phorbol ester",
"pos": [
139,
152
]
} | {
"id": "C0039654",
"name": "phorbol",
"pos": [
172,
179
]
} |
the transport of the naturally occurring amino acids , alanine , proline , and leucine was defined by studies of : ( 1 ) competitive inhibition with the system-specific synthetic amino acids , methyl-aib and bch , ( 2 ) the effect of the transcellular sodium gradient on transport , and ( 3 ) evaluation of the time-dependent increase of transport in amino acid-deficient medium ( adaptation ) . | NA | {
"id": "C0001898",
"name": "alanine",
"pos": [
55,
62
]
} | {
"id": "C0002520",
"name": "amino acid",
"pos": [
351,
361
]
} |
the effect of medium conditioned by confluent fibroblasts on ldl metabolism was tested to determine if the effects of cell density on ldl metabolism might be mediated by cellular secretion products . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
46,
57
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
103,
106
]
} |
swainsonine , an indolizidine alkaloid , found in plants of the genus swainsona , has been shown to be a strong inhibitor in vitro of the alpha-d-mannosidase activity in normal human fibroblasts . | NA | {
"id": "C0085535",
"name": "swainsonine",
"pos": [
0,
11
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
30,
38
]
} |
therefore , inhibition of alpha-d-mannosidase activity in extracts of harvested cells grown with swainsonine in the medium has been used to follow the association of the alkaloid with normal human fibroblasts in culture . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
80,
85
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
197,
208
]
} |
therefore , inhibition of alpha-d-mannosidase activity in extracts of harvested cells grown with swainsonine in the medium has been used to follow the association of the alkaloid with normal human fibroblasts in culture . | NA | {
"id": "C0085535",
"name": "swainsonine",
"pos": [
97,
108
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
170,
178
]
} |
swainsonine that could not be removed by extensive washing became associated with the cells within 1 min , and it is concluded that the alkaloid is internalized rapidly by the cells . | NA | {
"id": "C0085535",
"name": "swainsonine",
"pos": [
0,
11
]
} | {
"id": "C0002062",
"name": "alkaloid",
"pos": [
136,
144
]
} |
on freeze-fracture replicas we find : ( 1 ) a ninefold increase in small invaginations as the cell differentiates from the fibroblast to the adipocyte phenotype ; | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
94,
98
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
123,
133
]
} |
other cells flatten and attach to the substrate and resemble typical fibroblasts throughout the culture period . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
6,
11
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
69,
80
]
} |
some of the labelled components were shown to be proteoglycans and the labelled glycosaminoglycans released from them by trypsin were identified as hyaluronic acid ( 54 % ) , heparan sulphate ( 33 % ) and chondroitin sulphate ( 13 % ) . | NA | {
"id": "C0017973",
"name": "glycosaminoglycans",
"pos": [
80,
98
]
} | {
"id": "C0019143",
"name": "heparan sulphate",
"pos": [
175,
191
]
} |
spreading is slower in serum , in amniotic fluid lacking fibronectin and on type i collagen or cellular microexudate from fl cells or fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
125,
130
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
134,
145
]
} |
the highest reproducible concentration achieved was about 30 colonies ( containing fibroblasts , macrophages and endothelioid cells ) per 10 ( 6 ) nucleated marrow cells ( range 20-50 ) in mice 3-4 months old , and higher by 50 % in mice 14-15 months old . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
83,
94
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
164,
169
]
} |
this method allowed the cells to be grown in vitro for periods of up to 146 days , very considerably longer than in previously reported studies , and ensured that the cultures remained largely free from contaminating human fibroblasts . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
24,
29
]
} | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
223,
234
]
} |
the usher syndrome ( us ) refers to the combined neurosensory deficits of profound hearing impairment and retinitis pigmentosa . | NA | {
"id": "C0271097",
"name": "usher syndrome",
"pos": [
4,
18
]
} | {
"id": "C0018784",
"name": "neurosensory",
"pos": [
49,
61
]
} |
in order to evaluate the in vivo effects of biguanides on the insulin receptor , we have studied insulin binding to circulating monocytes of six normal controls , eight obese nondiabetic subjects , and six obese type ii diabetic patients , both before and after 4 days of treatment with the biguanide metformin ( 850 mg twice daily orally ) . | NA | {
"id": "C0005382",
"name": "biguanide",
"pos": [
44,
53
]
} | {
"id": "C0025598",
"name": "metformin",
"pos": [
301,
310
]
} |
cell-free translation of the tumor mrna produced authentic proopiomelanocortin of 35,000 mol wt , indicating that the acth and beta lph were produced by the tumor from a common precursor . | NA | {
"id": "C0033195",
"name": "proopiomelanocortin",
"pos": [
59,
78
]
} | {
"id": "C0023832",
"name": "beta lph",
"pos": [
127,
135
]
} |
the effect of oral tyrosine or tryptophan ingestion on plasma concentrations of norepinephrine ( ne ) , dopamine ( da ) , epinephrine ( epi ) , and 3,4-dihydroxyphenylacetic acid ( dopac ) was investigated in a double blind , placebo-controlled study in fasted men . | NA | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
80,
94
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
122,
133
]
} |
tyrosine ingestion induced within 45 min a significant but short-lasting ( approximately 30 min ) increase in plasma concentrations of ne , epi , and da and a coincident decrease in plasma dopac levels . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
6,
8
]
} | {
"id": "C0014563",
"name": "epi",
"pos": [
140,
143
]
} |
ingestion of tryptophan or lactose placebo did not after plasma da , epi , ne , or dopac levels . | NA | {
"id": "C0014563",
"name": "epi",
"pos": [
69,
72
]
} | {
"id": "C0028351",
"name": "ne",
"pos": [
75,
77
]
} |
they were treated with large doses of vitamin d3 derivatives [ 25-hydroxyvitamin d3 ( 25- ( oh ) d3 ) , 1,25- ( oh ) 2d3 , and 1 alpha-hydroxyvitamin d3 ] for 28 months and 6 yr , respectively . | NA | {
"id": "C0006657",
"name": "25-hydroxyvitamin d3",
"pos": [
63,
83
]
} | {
"id": "C2713074",
"name": "25",
"pos": [
106,
108
]
} |
these findings indicate that the fp activity of the dominant follicle correlates with its state of differentiation , as described by intrafollicular estradiol , progesterone , 17-hydroxyprogesterone levels and inhibin activity . | NA | {
"id": "C0033308",
"name": "progesterone",
"pos": [
161,
173
]
} | {
"id": "C0020387",
"name": "17-hydroxyprogesterone",
"pos": [
176,
198
]
} |
during srif infusion , the initial small decrease in blood glucose was followed by a rise of epinephrine from 25-46 ng/liter ( range ) to 117-143 ng/liter ( range ) ( p less than 0.05 ) at 80 min and norepinephrine from 204 +/- 16 to 418 +/- 60 ng/liter at 90 min ( p less than 0.05 ) . | NA | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
93,
104
]
} | {
"id": "C0028351",
"name": "norepinephrine",
"pos": [
200,
214
]
} |
during high-dosage hfsh administration , serum fsh levels increased to 273+/-44 ng/ml ( just above the normal range for fsh , 30-230 ng/ml ) . | NA | {
"id": "C0016774",
"name": "hfsh",
"pos": [
19,
23
]
} | {
"id": "C0733758",
"name": "fsh",
"pos": [
120,
123
]
} |
in the one man who received low dosage hfsh treatment , sperm counts were reduced to severely oligospermic levels , serum fsh was suppressed to undetectable levels , and serum lh bioactivity was markedly lowered during the t-alone period . | NA | {
"id": "C0016774",
"name": "hfsh",
"pos": [
39,
43
]
} | {
"id": "C0733758",
"name": "fsh",
"pos": [
122,
125
]
} |
the capacity of insulin to facilitate progesterone biosynthesis by ovarian cells was mimicked by the insulinlike somatomedin , multiplication stimulating activity , but not by epidermal growth factor , fibroblast growth factor , or porcine relaxin . | NA | {
"id": "C0037657",
"name": "somatomedin",
"pos": [
113,
124
]
} | {
"id": "C0021666",
"name": "multiplication stimulating activity",
"pos": [
127,
162
]
} |
these differences are two amino acids in the a chain , alpha loop , of beef insulin and the single terminal amino acid , alanine , which is common to pork and beef insulins . | NA | {
"id": "C0002520",
"name": "amino acid",
"pos": [
26,
36
]
} | {
"id": "C0001898",
"name": "alanine",
"pos": [
121,
128
]
} |
positive responses to both beef proinsulin and pork proinsulin demonstrated the capability of restricted recognition of more complex proteins represented by the c-peptide in these insulin preparations . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
32,
42
]
} | {
"id": "C0006558",
"name": "c-peptide",
"pos": [
161,
170
]
} |
positive responses to both beef proinsulin and pork proinsulin demonstrated the capability of restricted recognition of more complex proteins represented by the c-peptide in these insulin preparations . | NA | {
"id": "C0033362",
"name": "proinsulin",
"pos": [
32,
42
]
} | {
"id": "C0021641",
"name": "insulin preparations",
"pos": [
180,
200
]
} |
the addition of guanylylimidodiphosphate ( 0.1 mm ) , a nonhydrolyzable derivative of guanosine triphosphate ( gtp ) , to pmn membrane preparations reduced the fraction of high-affinity receptors detected in equilibrium binding studies from 21.3 +/- 0.13 to 11.8 +/- 0.05 % ( p less than 0.03 ) , without altering the binding affinities . | NA | {
"id": "C0018366",
"name": "guanylylimidodiphosphate",
"pos": [
16,
40
]
} | {
"id": "C0018353",
"name": "guanosine triphosphate",
"pos": [
86,
108
]
} |
the guanine nucleotide effects were greatest with nonhydrolyzable derivatives of gtp followed by gtp then guanosine diphosphate . | NA | {
"id": "C0018328",
"name": "guanine nucleotide",
"pos": [
4,
22
]
} | {
"id": "C0018353",
"name": "gtp",
"pos": [
97,
100
]
} |
to assess the possibility that a defect in the dopaminergic mechanism might enhance aldosterone secretion in hypertensive patients , we determined basal and adrenocorticotropic hormone ( acth ) -stimulated plasma aldosterone ( pa ) , cortisol , renin activity , and potassium concentrations before and during dopamine receptor stimulation with dopamine infusion and bromocriptine administration and dopamine receptor blockade with metoclopramide . | NA | {
"id": "C0282151",
"name": "dopaminergic",
"pos": [
47,
59
]
} | {
"id": "C0013030",
"name": "dopamine",
"pos": [
399,
407
]
} |
since the drug-enzyme complex ( bound drug ) is slowly dissociable , an excess of drug ( unbound or free drug ) above that required to bind all enzyme sites is required in order to compete with substrate for sites made available by enzyme-drug dissociation . | NA | {
"id": "C0026741",
"name": "enzyme complex",
"pos": [
15,
29
]
} | {
"id": "C0014442",
"name": "enzyme",
"pos": [
232,
238
]
} |
in fibroblasts from the other three patients no decrease in total cellular levels of ar were seen ; | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
3,
14
]
} | {
"id": "C0007634",
"name": "cellular",
"pos": [
66,
74
]
} |
utilizing a [ 14c ] formate incorporation technique , rates of total cellular de novo purine synthesis as well as rates of de novo adenine , de novo guanine , and thymine synthesis and incorporation into rna and dna were measured as a function of hypoxanthine concentration . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
86,
92
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
131,
138
]
} |
in normal human marrow cells , the rate of total de novo purine synthesis declined by 81 % , while the rate of de novo adenine and de novo guanine synthesis and incorporation into macromolecules declined by 89 and 75 % , respectively , when media hypoxanthine was increased from 0 to 10 microm . | NA | {
"id": "C0034140",
"name": "purine",
"pos": [
57,
63
]
} | {
"id": "C0001407",
"name": "adenine",
"pos": [
119,
126
]
} |
activities of beta-hexosaminidase and alpha-mannosidase were significantly higher in cells from acute monocytic and acute myelomonocytic leukaemias , and somewhat higher in the other myeloid leukaemias , when compared with control granulocytes . | NA | {
"id": "C0023479",
"name": "acute myelomonocytic leukaemias",
"pos": [
116,
147
]
} | {
"id": "C0023470",
"name": "myeloid leukaemias",
"pos": [
183,
201
]
} |
the results of this study show that the pa activity in the vein vessel wall is immunologically similar to or identical to the pa derived from melanoma cells which has previously been shown to cross-react with the tissue-like pa . | NA | {
"id": "C0032144",
"name": "pa",
"pos": [
40,
42
]
} | {
"id": "C0032143",
"name": "tissue",
"pos": [
213,
219
]
} |
the 293 cells were found to be as sensitive as hek cells and human embryo fibroblast ( hef ) cells for the cultivation of adenoviruses and herpes simplex virus ( hsv ) respectively . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
8,
13
]
} | {
"id": "C0016030",
"name": "fibroblast",
"pos": [
74,
84
]
} |
as a continuous cell line , 293 cells are preferable to hek and hef cells for the routine isolation of ophthalmic viruses . | NA | {
"id": "C0007634",
"name": "cells",
"pos": [
32,
37
]
} | {
"id": "C0016030",
"name": "hef",
"pos": [
64,
67
]
} |
benzylpenicillin consistently inhibited the growth of 90 % of the isolates recovered on media free of antibiotics while ampicillin and amoxicillin frequently inhibited 99 % or more of the bacteria recovered . | NA | {
"id": "C0030827",
"name": "benzylpenicillin",
"pos": [
0,
16
]
} | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
120,
130
]
} |
benzylpenicillin consistently inhibited the growth of 90 % of the isolates recovered on media free of antibiotics while ampicillin and amoxicillin frequently inhibited 99 % or more of the bacteria recovered . | NA | {
"id": "C0002680",
"name": "ampicillin",
"pos": [
120,
130
]
} | {
"id": "C0002645",
"name": "amoxicillin",
"pos": [
135,
146
]
} |
in one case , the patient had applied a vitamin e preparation to the affected area , and tissue lipid analysis demonstrated large quantities of tocopherol and tocopheryl acetate . | NA | {
"id": "C0042874",
"name": "vitamin e preparation",
"pos": [
40,
61
]
} | {
"id": "C0078373",
"name": "tocopheryl acetate",
"pos": [
159,
177
]
} |
disorders in the metabolism of metallothionein , a metalloprotein involved in cellular copper transport , may be the primary defect in this syndrome . | NA | {
"id": "C0025545",
"name": "metallothionein",
"pos": [
31,
46
]
} | {
"id": "C0025544",
"name": "metalloprotein",
"pos": [
51,
65
]
} |
these results suggest that , in dh , immune complexes or antibodies derived from the gut can be deposited in the kidney . | NA | {
"id": "C0003313",
"name": "immune complexes",
"pos": [
37,
53
]
} | {
"id": "C0003241",
"name": "antibodies",
"pos": [
57,
67
]
} |
it is manifested clinically in two forms : wolman disease , which is usually fatal in infancy , and cholesteryl ester storage disease ( cesd ) , which is clinically milder . | NA | {
"id": "C0043208",
"name": "wolman disease",
"pos": [
43,
57
]
} | {
"id": "C0008384",
"name": "cholesteryl ester storage",
"pos": [
100,
125
]
} |
monoclonal antibodies will be useful in investigations applicable to bovine research including purification of immunoglobulins , determining immunoglobulin concentration in colostrum and milk , reference reagents for bovine serology , antibody localization in tissue , gene sequencing , characterizing histocompatibility antigens , distinguishing and quantitating cell types in blood , milk , and udder tissue , and elucidating role of cell subpopulations in the immune response . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
0,
21
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
235,
243
]
} |
attenuation of f 1 had different effects on phonetic identification in different subject groups : while listeners with noise-induced hearing loss showed substantial improvement in identifying place of articulation , upward spread of masking did not consistently account for poor place identification in other types of sensorineural hearing impairment . | NA | {
"id": "C0018781",
"name": "noise-induced hearing loss",
"pos": [
119,
145
]
} | {
"id": "C0018784",
"name": "sensorineural hearing impairment",
"pos": [
318,
350
]
} |
in crie the major allergen ( antigen 23 ) exhibited the strongest `` '' radiostaining , '' '' and only a few other components of birch pollen extract were visibly radiostained . | NA | {
"id": "C0002092",
"name": "allergen",
"pos": [
18,
26
]
} | {
"id": "C0003320",
"name": "antigen",
"pos": [
29,
36
]
} |
the major allergen and a preparation containing mainly the minor allergens , antigens 25 and 19 , were isolated from a crude aqueous birch pollen extract by a combination of anion-exchange , size-exclusion , and chelate chromatography . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
65,
74
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
77,
85
]
} |
between normal and glaucomatous subjects , a group with ocular hypertension exists which is not homogeneous as 10 p. cent of these will develop glaucoma . | NA | {
"id": "C0028840",
"name": "ocular hypertension",
"pos": [
56,
75
]
} | {
"id": "C0017601",
"name": "glaucoma",
"pos": [
144,
152
]
} |
these data suggest that newborn fibroblasts generally have greater mitogenic responsiveness than adult fibroblasts and that age-associated loss of growth factor responsiveness may indeed contribute to the decreased proliferative capacity of old cells . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
32,
43
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
245,
250
]
} |
the fractures were epiphyseal ( salter-harris type iii , n = 4 ) , ligament avulsions from metacarpal head ( n = 17 ) , osteochondral ( n = 8 ) , oblique ( sagittal , n = 22 ) , vertical ( coronal , n = 4 ) , horizontal ( transverse , n = 4 ) , comminuted ( n = 31 ) , boxer 's fractures with extension into the joint ( n = 3 ) , loss of substance ( n = 6 ) , and occult compression with avascular necrosis ( n = 4 ) . | NA | {
"id": "C0016658",
"name": "fractures",
"pos": [
4,
13
]
} | {
"id": "C0476171",
"name": "comminuted",
"pos": [
245,
255
]
} |
the intralobular distribution of nicotinamide adenine dinucleotide phosphate ( nadph ) -cytochrome c ( p-450 ) reductase ( nadph : ferricytochrome oxidoreductase , ec 1.6.2.4 ) in rat liver has been investigated by means of two quantitative immunohistochemical techniques : microdensitometric quantitation of unlabeled antibody peroxidase-antiperoxidase staining and microfluorometric analysis of indirect fluorescent antibody staining . | NA | {
"id": "C0027303",
"name": "nicotinamide adenine dinucleotide phosphate",
"pos": [
33,
76
]
} | {
"id": "C0001413",
"name": "nadph",
"pos": [
123,
128
]
} |
lectins linked to fluorescein were used as carbohydrate probes to examine the goblet cell mucin and epithelial cell surface glycoconjugate alterations in an experimental rodent model of colonic neoplasia induced with parenteral 1,2-dimethylhydrazine dihydrochloride . | NA | {
"id": "C0007004",
"name": "carbohydrate",
"pos": [
43,
55
]
} | {
"id": "C0017906",
"name": "glycoconjugate",
"pos": [
124,
138
]
} |
the specificity and cross-reactivity of these eight monoclonal antibodies and one heterologous antiserum against each of the two central nervous system ( cns ) antigens were examined in a histological study using the immunoperoxidase , antibody sandwich technique in rat and human brain tissue . | NA | {
"id": "C0003250",
"name": "monoclonal antibodies",
"pos": [
52,
73
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
the specificity and cross-reactivity of these eight monoclonal antibodies and one heterologous antiserum against each of the two central nervous system ( cns ) antigens were examined in a histological study using the immunoperoxidase , antibody sandwich technique in rat and human brain tissue . | NA | {
"id": "C0020960",
"name": "antiserum",
"pos": [
95,
104
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
236,
244
]
} |
controls in this and other studies demonstrate that the ne labels only ne ( and possibly epinephrine ) terminals and not dopaminergic or serotonergic terminals . | NA | {
"id": "C0028351",
"name": "ne",
"pos": [
56,
58
]
} | {
"id": "C0014563",
"name": "epinephrine",
"pos": [
89,
100
]
} |
analysis of the antigenic heterogeneity of db region products by the technique of antibody-induced redistribution of cell surface antigens ( capping ) revealed the existence of two types of h-2 molecules reactive with the monoclonal anti-db antibody , b22-249r 1 ( h-2.m2 ) . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
82,
90
]
} | {
"id": "C0003250",
"name": "monoclonal",
"pos": [
222,
232
]
} |
however , when at4ii , at4iv and their subclones were tested on pokeweed mitogen stimulated peripheral blood mononuclear cells , it was found that at4iv provided help for immunoglobulin production whereas at4ii cells were strongly suppressive . | NA | {
"id": "C1321301",
"name": "peripheral blood mononuclear cells",
"pos": [
92,
126
]
} | {
"id": "C0007634",
"name": "cells",
"pos": [
211,
216
]
} |
human lymphocyte function associated antigen-1 ( lfa-1 ) : identification of multiple antigenic epitopes and their relationship to ctl-mediated cytotoxicity . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
86,
95
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
96,
104
]
} |
titration of each of the anti-lfa-1 mab in a 51chromium release cytolytic assay revealed quantitative differences in the ability of the different anti-lfa-1 mab to block cytolysis indicating distinct functional and antigenic epitopes exist on the human lfa-1 molecule . | NA | {
"id": "C0003320",
"name": "antigenic",
"pos": [
215,
224
]
} | {
"id": "C0003316",
"name": "epitopes",
"pos": [
225,
233
]
} |
in contrast , in vivo injection of anti-id serum before immunization with tbm resulted in a ) significant selective suppression of antibodies to the autologous collagenase-solubilized tbm moiety but not to antigenic determinants of the intact tbm nor to those of heterologous tbm , and b ) a corresponding decrease of tin . | NA | {
"id": "C0021013",
"name": "id",
"pos": [
40,
42
]
} | {
"id": "C0003316",
"name": "antigenic determinants",
"pos": [
206,
228
]
} |
sequential purification through aca54 gel filtration , deae-sephacel ion exchange chromatography , and buffer electrofocussing clearly resolved the b cell growth and differentiation factor ( bgdf ) from the csf activities but failed to separate bgdf from il 1 . | NA | {
"id": "C0021758",
"name": "bgdf",
"pos": [
191,
195
]
} | {
"id": "C0021764",
"name": "il 1",
"pos": [
255,
259
]
} |
the wehi-3-derived material responsible for bgdf/il 1 activity , however , exhibited different behavior on deae chromatography ( elution at 175 mm nacl ) to that reported for il 1 from the p388d1 cell line ( elution at 50 mm nacl ) . | NA | {
"id": "C0021758",
"name": "bgdf/il 1",
"pos": [
44,
53
]
} | {
"id": "C0021764",
"name": "il 1",
"pos": [
175,
179
]
} |
b cell growth and differentiation could be induced by wehi-3 bgdf/il 1 in cultures of normal spleen cells depleted of t cells and adherent cells but not in cultures of spleen cells from b cell-deficient cba/n mice , even though thymocytes from such mice displayed a normal response to il 1 . | NA | {
"id": "C0021758",
"name": "bgdf/il 1",
"pos": [
61,
70
]
} | {
"id": "C0021764",
"name": "il 1",
"pos": [
285,
289
]
} |
cytotoxicity tests with alloantisera were used to study the expression of hla-d region antigens in hla-dr-null mutants of a human lymphoblastoid cell line . | NA | {
"id": "C0019754",
"name": "hla-d",
"pos": [
74,
79
]
} | {
"id": "C0019764",
"name": "hla-dr",
"pos": [
99,
105
]
} |
the predominance of the relatively uncommon v region subgroup isotype kappa iii among the light chains of human monoclonal ( igm kappa ) anti-igg antibodies , ( i.e. , rheumatoid factors ) , was further documented through sequence analyses of ten such autoantibodies isolated from igm-anti-igg cold-insoluble immune complexes ( mixed cryoglobulins ) . | NA | {
"id": "C0035448",
"name": "rheumatoid factors",
"pos": [
168,
186
]
} | {
"id": "C0004358",
"name": "autoantibodies",
"pos": [
252,
266
]
} |
another pentameric molecule , the acute-phase reactant c-reactive protein ( crp ) , shares major amino acid sequence homology with sap although , in man , sap is not an acute-phase reactant . | NA | {
"id": "C0006560",
"name": "c-reactive protein",
"pos": [
55,
73
]
} | {
"id": "C0001347",
"name": "acute-phase reactant",
"pos": [
169,
189
]
} |
to determine if the heparin matrix of ingested granules could be degraded by fibroblasts after phagocytosis , the heparin within peritoneal mast cells was labeled with [ 35s ] sulfate in vivo . | NA | {
"id": "C0016030",
"name": "fibroblasts",
"pos": [
77,
88
]
} | {
"id": "C0007634",
"name": "the",
"pos": [
110,
113
]
} |
two distinct mechanisms of cytotoxicity by porcine alveolar macrophages in antibody-dependent and immobilized immune complex-dependent cellular cytotoxicity . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
75,
83
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
110,
124
]
} |
in order to determine whether the macrophage tumoricidal and larvicidal activation observed in mice as a result of s. mansoni infection are mediated through t cell-dependent ( lymphokine ) or b cell-dependent ( antibody or immune complex ) mechanisms , the development of macrophage populations with cytotoxic activity against schistosome larvae or tumor cells was monitored in s. mansoni-infected nude or mu-suppressed mice . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
211,
219
]
} | {
"id": "C0003313",
"name": "immune complex",
"pos": [
223,
237
]
} |
individuals with te recognized both anodic and cathodic antigens as allergens , whereas the other two groups recognized predominantly anodic antigens . | NA | {
"id": "C0002092",
"name": "allergens",
"pos": [
68,
77
]
} | {
"id": "C0003320",
"name": "antigens",
"pos": [
141,
149
]
} |
these findings demonstrate that these t lymphoma cell surface molecules do not represent the t cell immunoglobulin receptor for antigen unless gp 70 itself is an antigen receptor . | NA | {
"id": "C0034790",
"name": "t cell",
"pos": [
93,
99
]
} | {
"id": "C0034788",
"name": "antigen receptor",
"pos": [
162,
178
]
} |
thus sia profiles of precipitated human albumin ( hsa ) and anti-hsa as checkerboard analysis permit : ( 1 ) determination of optimal proportions of antibody and antigen , ( 2 ) titration of antiserum as to antigen-binding capacity and ( 3 ) estimation of the concentration of specific antibody in an antiserum . | NA | {
"id": "C0003241",
"name": "antibody",
"pos": [
149,
157
]
} | {
"id": "C0020960",
"name": "antiserum",
"pos": [
301,
310
]
} |
the procedure requires less than a microgram of radiolabeled antigen and can be used to titer antisera containing less than 1 microgram/ml of precipitating antibody . | NA | {
"id": "C0020960",
"name": "antisera",
"pos": [
94,
102
]
} | {
"id": "C0003241",
"name": "antibody",
"pos": [
156,
164
]
} |
the relative stability of hla antigens as shown in this report and the extensive polymorphism of the hla system make the elisa technique a promising tool for the analysis of hla antigens on non-living cells including , for example , medicolegal investigation of blood stains . | NA | {
"id": "C0019721",
"name": "hla antigens",
"pos": [
26,
38
]
} | {
"id": "C0019728",
"name": "a",
"pos": [
270,
271
]
} |
the antibiotics tested included penicillin/ampicillin , erythromycin , tetracycline , chloramphenicol and four third-generation cephalosporins , cefotaxime , cefoperazone , ceftriaxone and moxalactam . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
145,
155
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
173,
184
]
} |
three of the newer third-generation cephalosporins -- cefotaxime , cefoperazone and ceftriaxone -- were highly active against both h. influenzae and str . pneumoniae while moxalactam , though also active , was comparatively less effective . | NA | {
"id": "C0007554",
"name": "cefotaxime",
"pos": [
54,
64
]
} | {
"id": "C0007561",
"name": "ceftriaxone",
"pos": [
84,
95
]
} |
the test is unlikely to be of much help in differentiating partly treated bacterial meningitis from virus meningitis , but it is a valuable additional procedure for differentiating tuberculous meningitis from virus meningitis , highly modified bacterial meningitis and parameningeal septic states . | NA | {
"id": "C0041318",
"name": "tuberculous meningitis",
"pos": [
181,
203
]
} | {
"id": "C0085437",
"name": "bacterial meningitis",
"pos": [
244,
264
]
} |
of several dinitrobenzenes tested , 2,4-dinitrothiocyanatebenzene ( dntb ) was found to be the only one that did not induce contact sensitivity when applied to the guinea pig ear epicutaneously , but when applied epicutaneously it induced tolerance to 2,4-dinitrofluorobenzene ( dnfb ) . | NA | {
"id": "C0012459",
"name": "dinitrobenzenes",
"pos": [
11,
26
]
} | {
"id": "C0012463",
"name": "dinitrofluorobenzene",
"pos": [
256,
276
]
} |
the manner in which dnfb , dntb , and other dinitrobenzene compounds conjugated in vitro to soluble proteins , at physiologic ph , was examined . | NA | {
"id": "C0012463",
"name": "dnfb",
"pos": [
20,
24
]
} | {
"id": "C0012459",
"name": "dinitrobenzene",
"pos": [
44,
58
]
} |
untreated and complement ( c ' ) -treated ec induced strong cytotoxic t lymphocyte ( ctl ) activity in highly purified allogeneic t cells and , in analogy , tnp-modified ec led to the generation of tnp-self ctl , as tested in 4-h 51cr release assays against allogeneic or tnp-modified syngeneic ec or sc targets . | NA | {
"id": "C3485979",
"name": "allogeneic",
"pos": [
119,
129
]
} | {
"id": "C0007634",
"name": "sc",
"pos": [
301,
303
]
} |
in contrast , a disorganized pattern consisting of cells with various staining intensities was observed in bowen 's disease ( 2 ) and squamous cell carcinoma ( 4 ) . | NA | {
"id": "C0006079",
"name": "bowen 's disease",
"pos": [
107,
123
]
} | {
"id": "C0007137",
"name": "squamous cell carcinoma",
"pos": [
134,
157
]
} |
the inhibition of acantholysis was not caused by cell death since methylprednisolone did not alter keratinocyte viability as determined by exclusion of trypan blue dye when keratinocytes were exposed to pemphigus plasma . | NA | {
"id": "C0007634",
"name": "cell",
"pos": [
49,
53
]
} | {
"id": "C0022567",
"name": "viability",
"pos": [
112,
121
]
} |
the protective activity of acellular pertussis vaccine was comparable to that of whole cell vaccine against intracerebral and aerosol infection with bordetella pertussis in mice . | NA | {
"id": "C0006015",
"name": "infection",
"pos": [
134,
143
]
} | {
"id": "C0043167",
"name": "pertussis",
"pos": [
160,
169
]
} |
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