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Senior Scientist . . Having more than a decade of experience in the field of cryo electron microscopy cryo EM and working on various structural biology projects , Kushal has explored the complete EM pipeline : from the benchwork to purification of macromolecules ; to sample preparation for cryo EM ; to collecting high resolution EM data ; to image processing and 3D reconstruction ; and finally to model building and analysis . Serving as an academic researcher for 10 years , he transitioned to industry to venture into new opportunities and possibilities . Currently , as a senior scientist at Vironova AB , he provides GMP compliant EM services to the pharma industry for the analysis of vaccines , gene therapy and drug delivery nanoparticles .. Technologies : CryoEM
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carriers;structure
|
Team Lead Conjugation . . I spent several years as a PhD student in the lab of Prof. Markus Wahl at the Freie Universit t Berlin working on molecular mechanisms of spliceosome activation and I obtained my doctoral degree in biochemistry in 2018 . My work was published in several renowned peer reviewed journals PNAS , eLife . I have a strong expertise in protein and RNA biochemistry , structural biology and enzyme kinetics . In 2018 , I joined EUROIMMUN as a Research Scientist in antibody development for IVD , with a main interest in antibody conjugation for chemiluminescent immunoassay technology .. Technologies :
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antibodies;developing
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Konsulent . . P dagogisk antropolog med stor interesse , viden og erfaring i at unders ge kulturelle forhold og sociale processer i relationer , institutioner , organisationer og virksomheder . Jeg har specialiseret mig i det psykisk sociale arbejdsmilj , med s rligt fokus p ledelses medarbejder forhold , kommunikationsformer og identitetsskabelse . Jeg g r til arbejdsopgaver med en unders gende , analytisk og systematisk tilgang , og arbejder gerne ud fra et bredt spektrum af kvalitative og kvantitative metodiske redskaber . Jeg har spidskompetencer i at arbejde strategisk og s tte spot p nye sammenh nge og m nstre . Jeg drives af at v re med til at skabe v rdifulde praksisser , hvor udvikling , trivsel og l ring underst ttes . I mit arbejde kendetegnes jeg ved at v re udadvendt , dialogskabende , ih rdig , velorganiseret og handlekraftig . Samtidig ser jeg humor og en uformel omgangstone som en vigtig del af et godt arbejdsliv . Derudover har jeg en professionsbachelor som p dagog og har dybdeg ende faglig viden samt praksis erfaring indenfor b de dagtilbud , skole og social special omr det .. Technologies :
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Professor of Theoretical and Computational Biology . . . Technologies :
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Scientist . . I am a Biotech Engineer with 7 years of experience in biotech and pharmaceutical industry . Currently I work as a Scientist in Process Development team at Kiadis Pharma . I 'm responsible for development and optimization of cell therapy products CMC , executing technology transfer activities , reviewing technical documentations . I have understanding and experience of cell therapy GMP manufacturing . Previously , I worked as a Scientist Assistant in Swiss biotech company , where I was responsible for upstream of mononuclear antibody production . All my gained experience skilled me to be fast learner while meeting rigorous tasks and demanding schedules . Moreover , I am able to work under time pressure as a part of the team and independently . I thrive on challenges and I will spend the time and effort it takes to fulfill it . . Technologies :
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biologics;developing;quality
|
Research Scientist Cryo EM . . I am a Protein Biochemist with several years of experience in membrane proteins and cryo electron microscopy . I have profound analytical skills and great communication skills in presenting complex science and data . Through working in international teams , I have gained intercultural experiences that shaped the way of my professional and personal life .. Technologies : CryoEM
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membrane proteins;structure
|
Quantitative Research Analyst . . I develop proprietary , and applying existing , machine learning and statistical techniques for use in a large medium low frequency daily to monthly prediction horizon systematic equities strategy which is traded globally . My main focus has been signal generation , although I have also worked on portfolio optimisation . Prior to working in finance , I was a posdoctoral researcher at the University of Nottingham where I conducted research into machine learning , statistics and computational biology . My work has appeared in top machine learning and applied maths journals including KDD 2015 in Sydney https : scholar.google.com citations user Ave6hfMAAAAJ hl en . I have a PhD in applied maths , awarded in 2010 . I came fourth in the Kaggle brain computer interface machine learning challenge for the classification of multi variate EEG time series signals . I was subsequently interviewed for the Kaggle winner s blog , which you can read online here https : medium.com kaggle blog winners interview bci challenge ner2015 f851dc2599a0 .. Technologies :
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Cryo EM Research Professional . Cryo EM expert support for single particle structure determination projects in the Biochemistry department . Scientist with a PhD in Biochemistry and Molecular Biophysics from The University of Chicago , with additional skills working with C C and Python programming . Currently focused on the purification of diverse and difficult proteins and determining their structure s by cryo electron microscopy . I am interested particularly in structural biology , using computational tools to improve the accuracy and throughput of biochemistry wet lab techniques , and finding or creating software to effectively to solve biochemical and structural problems . Skills include : optimization of protein purification , chromatography , crystallography , cryo EM , protein DNA machines , FRET and fluorescence anisotropy , and computer hardware software for scientific needs .. Technologies : CryoEM;FP;FRET
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proteins;structure
|
Director Medicinal Protein Chemistry . . Following his PhD study in the Organic Chemistry department at the Radboud University in Nijmegen , The Netherlands , Patrick co founded and built Syntarga , a biopharmaceutical company developing Antibody Drug Conjugate technology . After Syntarga 's acquisition by Synthon in 2011 , he headed the Antibody Drug Conjugates department within Synthon Biopharmaceuticals , now Byondis . Since 2014 , he is leading the Medicinal Protein Chemistry department , focusing on the early stage development of both antibody drug conjugates and small molecule drugs . At the same time , he is also leading R D projects as a project manager . He has a focus on early stage R D and a strong interest in both platform and product development . . Keywords : Organic Chemistry , Protein Chemistry , Medicinal Chemistry , Project Management , R D Strategy , Pharmaceutical , Biotech Life Sciences Industries . Values : Teamwork , Collaboration , Incitement , Excellence , Growth , Enjoyment . Technologies :
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antibodies;small molecules;engineering
|
PhD Fellow . Optimization of fragment derived small molecule Keap1 inhibitors by advanced medicinal chemistry strategies macrocycles , prodrugs and PROTACs UBIMOTIF Marie Sk odowska Curie . . Technologies :
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molecular glues;small molecules;developing
|
Institute Research Investigator Structural Biology . . I am a membrane protein biochemist and have been using cryo EM as a tool to understand the structure function relationship of various membrane proteins by reconstituting them into lipid nanodiscs . Cryo EM is a very powerful technique to visualize protein and protein complexes in their close to native state . I have extensive experience in various biophysical methods and single particle image analysis , 3 D reconstruction of protein and protein complexes using cryo electron microscopy . . Technologies : CryoEM
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membrane proteins;structure
|
Research Associate . New Antibody Product Research Alternative Immune Reactive Cells in Oncology AIRCO team . . Technologies :
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antibodies;developing
|
. . Biochemist focusing on the function and structure of membrane proteins by studying cytochrome c oxidase kinetics with high time resolved spectroscopic methods such as flash photolysis and flow flash . Interested in : Developing better methods for science communication , both to non scientists and colleges . Improving collaborations and networks in and between universities and companies in the Stockholm Uppsala region . Specialties : Communicating science , membrane protein expression and purification , spectroscopy , enzyme kinetics , cytochrome c oxidase , proton pumping across biomembranes , flow flash technique , flash photolysis .. Technologies :
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membrane proteins;structure
|
Associate Scientific Director Team Leader AI Design Team . I have more than fifteen years of drug design experience supporting projects across all therapeutic areas from early target identification to late lead optimization , as well as rationalising design implications of clinical data . I have a strong track record in the business integration of data analytics , large scale multi task learning AI approaches and cloud environments into a pharmaceutical context and have created , coordinated and delivered various strategic innovation initiatives along such lines with multiple million Euros of budget . This includes , but is not limited to collaborating with many partners , covering academic groups , data analysts , software engineers , medicinal chemists , biologists , and other drug development companies . I have successfully delivered business value to therapeutic area projects using AI and are leading a team of multiple FTE to support our internal drug design project teams as well as driving the strategic AI initiatives . In addition , I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Additional skills : project coordination , team leader , contract negotiations , structure based drug design , fragment based drug design , drug resistance modelling , MBTI : ENTJ . I have more than fifteen years of drug design experience supporting projects across all therapeutic areas from early target identification to late lead optimization , as well as rationalizing design implications of clinical data . I have a strong track record in the business integration of data analytics , large scale multi task learning AI approaches and cloud environments into a pharmaceutical context and have created , coordinated and delivered various strategic innovation initiatives along such lines with multiple million Euros of budget . This includes , but is not limited to collaborating with many partners , covering academic groups , data analysts , software engineers , medicinal chemists , biologists , and other drug development companies . I have successfully delivered business value to therapeutic area projects using AI and are leading a team of multiple FTE to support our internal drug design project teams as well as driving the strategic AI initiatives . In addition , I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Due to a computer science background I am also strategically interested in risk reduction and data analytics . I am an avid problem solver , am used to working successfully in a fast paced dynamic environment and am a strong believer in diverse teams to reach a business integration and cutting edge innovation . Additional skills : project coordination , team leader , contract negotiations , structure based drug design , fragment based drug design , drug resistance modelling , pro activity , information management , computer science expertise , high reading affinity , MBTI : ENTJ . Technologies :
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Assistant Professor . I am starting up my own group in the Department of Molecular and Cellular Biology . Our research will focus on the structures and functions of electron transport membrane proteins . . I am an Assistant Professor of Molecular and Cellular Biology at UC Davis . Previously I was a Marie Sk odowska Curie fellow at IST Austria in the laboratory of Dr. Leonid Sazanov . I did my PhD at the Rockefeller University in the Laboratory of Molecular Neurobiology and Biophysics with Dr. Roderick MacKinnon . I am interested in continuing research in the biophysics of membrane proteins . With a special interest in structure function studies using single molecule cryoEM . Please check out the video below to watch the public presentation portion of my thesis defense . Introduction by Rod MacKinnon . My full thesis can be found here : http : dspace2.rockefeller.edu jspui handle 10209 554 See below for a list of selected publications or check out my ReseachGate profile for a complete list . Specialties : Membrane protein biochemistry , biophysics and structure .. Technologies :
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membrane proteins;characterization;structure
|
Bioinformatics manager . . Since I was in high school , science based subjects intrigued me , especially biology . I was also fascinated by computer science . Therefore , I chose to get my BSc in Biology and MSc in Bioinformatics , thus succeed in combining those two fields of study . As a Newly Graduated with a MSc in Bioinformatics , I am looking for opportunities to apply and further develop my bioinformatics skills . In my two years of lab experience I have learned to be a productive team player and developed strong communication skills . Time management and prioritization of tasks was also crucial to meet certain deadlines . While attending the Post Graduate Program and working in the lab I have also developed skills that are more related to IT , including , knowledge of working with operating systems WINDOWS , UNIX , LINUX and Mac OSX , Programming C , Perl , Python and Java , Database Design and Management in MySQL and use of Bioinformatics as well as Biostatistics tools . I am currently seeking a position in bioinformatics . Particularly , I am interested in programming , analysis of biomolecular sequences and biomolecular structures , molecular recognitions and structural drug design .. Technologies :
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Head of Cryo Electron Microscopy Core Facility . . As Head of the Cryo Electron Microscopy Core Facility at Human Technopole , I am responsible for maintaining a facility capable of state of the art multi flavoured electron microscopy single particle , single cell , electron tomography and CLEM .. Technologies : CryoEM
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Process Scientist . . Sr . Manufacturing Process Specialist Process Owner . Process Owner of Mosaic , DSP a New Product Introduction NPI , Mosaic is a protein HIV preventive vaccine regimen in phase 3 clinical trials . . Process Owner of RSV f , DSP in transition from NPI to commercial production , RSV f is a protein based on the production of adenoviral vectors to activate the human immune system . . Process Owner of Sylvant USP DSP , a commercially established oncology protein IgG , and is recently in decommissioning . Perform impact assessment to determine potential product equipment license impact because of the quality issue . Investigation lead and define corrections and or CPA s. Participates in comprehensive engineering activities to develop and implement effective , high quality process and design guidelines for dissemination throughout the division . . Provide complex design reviews and feedback for improvements in manufacturability . Implements equipment , materials , and process performance requirements , perform vendor searches and equipment evaluation to ensure the adequate capacity to produce quality products in required quantities at an effective cost . . Facilitate experiments and capability studies , develop process specifications , and design and procure process tools . . Evaluate and advise on the selection of suitable equipment for optimized , balanced line performance . Process analyses of new systems and equipment with the intent of achieving continuous improvement of present methods . . Edit and publish process documentation and training materials for processes , materials , and equipment . Conduct all activities in strict accordance with cGMP regulations and EH S policy . Highly innovative , proactive , and creative Sr . process scientist with a strong sense of ownership . . I feel uncomfortable when people suggest : It can t be done I like challenges and I am resourceful in finding solutions . . In previous work : . I created and implemented a new production process for the purification of antibodies of Mastivax s . replacement of antibiotics . . Co inventor of the patented DSM technology Single use antibody purification . Developed a new cGMP compliant technology EBA , RHOBUST and implemented this for global . DSM sites and its customers . . Technologies :
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biologics;carriers;developing
|
Scientist . . Neslihan Ta is an environmental microbial ecologist and a Research Scientist in the Climate Ecosystems Division at Berkeley Lab . Dr. Ta studies microbial transformation of natural and anthropogenic carbon in terrestrial and aquatic ecosystems . She received her Ph.D. and MSc from Wageningen University in the Netherlands . Dr. Ta s current research projects spans from studying impact of climate change in soil microbial functions in the Arctic to fate of terrestrial carbon in aquatic ecosystems . Dr. Ta s expertise lies on applications of multi omic technologies in order to understand microbial function in the environment .. Technologies :
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Researcher . . With extensive experience in the field of Bioinformatics , Bacteriology , Molecular Biology , Protein Biochemistry , Structural biology and Drug discovery , I wish to continue my research in these areas . I have a huge interest in understanding host pathogen interactions using various techniques and data analytics , thus hoping to contribute towards discovering mechanisms enabling the development of improved diagnostics and treatment strategies , thus contributing towards developing a better future . I enjoy reading and learning PhotoVideography in my free time . Google Scholar : http : scholar.google.co.in citations user ML7X29AAAAAJ hl en Research Gate : https : www.researchgate.net profile Sanjiv Kumar2 contributions ev prf act Thank you for visiting my profile . Please let me know if you have any questions Email : drsanjivk gmail.com . Feel free to connect .. Technologies : DSC;CD
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membrane proteins;interaction
|
Postdoctoral Researcher . Beckmann group at the Gene center Munich Structural studies of co translational quality control using cryo EM . . Currently researching quality control response to aberrant translation using cryo EM . For an up to date publication list please check : https : www.researchgate.net profile Petr Tesina https : scholar.google.com citations user e eUxZoAAAAJ . Technologies : CryoEM
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quality;structure
|
Senior Staff Scientist Mass Spectrometry . Clinical proteomics mass spectrometry . Experienced Staff scientist with a demonstrated history of working in the biotechnology industry . Skilled in Membrane Proteins , Liquid Chromatography Mass Spectrometry LC MS , Clinical Proteomics , Protein Purification and targeted Mass Spectrometry . Strong LC MS experimental design professional with a Doctor of Philosophy Ph.D. focused in Biological chemistry from the University of Ioannina .. Technologies :
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Vice President Enzyme Research . . Industrial biotechnology holds the promise of solving a large amount of the problems associated with a densely populated world and a changing climate . Recent developments in automation , data driven molecular discovery and experimental methods have made it possible to develop new biotech solutions enzymes , drugs , microbes and production strains faster than ever before . The next few decades will likely see a revolution in how widely these solutions are adapted across industries from food production to chemical engineering to provide a greener better world for all of us . I am currently heading up the Enzyme Research area at Novozymes . My daily tasks include developing business and R D strategies as well as ensuring progress in our discovery projects . I have almost a decade of academic experience as Senior Lecturer at University College Dublin . 25 years of research experience in bioinformatics , programming , data analysis , protein analysis and protein engineering design , with protein electrostatics and protein stability as a specialty . 50 peer reviewed papers , 8000 citations , H index of 34 , 8 patents . List of publications including number of citations is available at Google Scholar : http : scholar.google.ca citations user CvQ4t90AAAAJ Specialties : Protein engineering , data driven molecule optimization , protein pKa calculations , Structural bioinformatics , enzyme structure function studies , algorithm development for protein structural energy calculations . Technologies :
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enzymes;proteins;characterization;engineering;stability
|
Bioinformatics Core Director . . I am setting up a Bioinformatics Core at The University of Sheffield . We will provide high quality Bioinformatics service to assist researchers in the planning , analysis , visualisation and interpretation of their high throughput data . We will also provide training courses on essential data analysis skills and more specialised training in the analysis of NGS related data . http : sbc.shef.ac.uk . Technologies :
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ProRector for Research ProRettore alla Ricerca of the University of Pavia . . My principal research interest is the elucidation of the intricate mechanisms of protein protein interaction and signaling . The various processes that fall under the description of molecular recognition ranging from transient inter molecular interactions , conformational changes , proteolysis mediated activation and inhibition , to many others represent for me one of the most fascinating aspects of nature elegance and complexity . I merge structural biology with biochemistry and biophysics to characterize large macromolecular complexes and elucidate their structure function relationship to put the molecular insights in the proper biological context . I am co author of 40 publications in international peer reviewed scientific journals of high profile including Science , PNAS , J. Neurosci , Cell Reports and JACS 15 papers as first author and 3 book chapters 2 of them as first author . I am a board member of AIRIcerca , the association of Italian researchers aiming at increasing the networking opportunities among researchers and promoting scientific knowledge among the Italian population , and I am currently serving as Editor in Chief of the association 's science popularization journal AIRInforma .. Technologies : Xray;CryoEM;NMR
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proteins;characterization;interaction;structure
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Principal Scientist . . . Technologies :
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Staff Scientist , Bioinformatics Software Engineer . Led the design and development of the annotations pipeline of Ion Reporter IR , a leading bioinformatics analysis software suite , built upon the cloud on Amazon AWS and local servers . Designed and developed an automated end to end software workflow which consists of millions of records from multiple public and private genomic annotation databases that helps customers annotate their genomic variants to efficiently analyze and identify driver mutations in clinical research . Designed and implemented a novel algorithm PATENT US 20130091126 A1 to resolve ambiguous indels when annotating variants using Genome Analysis Toolkit GATK . Team lead of a remote software engineering team at Bangalore , India for the past 5 years . Planned software deliverables , distributed and discussed ongoing work with the team , guided and performed code reviews . Designed and implemented a new software pipeline in Python to analyze Alpha Beta diversity using QIIME Quantitative Insights Into Microbial Ecology for Metagenomics16S NGS based workflows . Designed and developed novel application features in Java , Python and mongoDB using GIT for source code version control , maven for dependency control and Eclipse IDE and participated in scrums and sprint planning following agile production software development life cycle SDLC . Involved in development of a software analysis pipeline to detect CNVs Copy Number Variants from Ion Torrent sequencing reads using a machine learning approach utilizing Hidden Markov Models . Designed and developed a distributed Java workflow , inspired by the Map Reduce pattern for the CNV pipeline . Led the efforts to successfully support GRCh38 Human Reference genome with alternate loci in IR software with minimal architecture design changes both in the code and representation of the data in the database tables . Contributed to the development of HGVS notations of variants into IR . . Software Engineer with experience in software development , machine learning , data analysis and bioinformatics . 8 years of programming experience in agile production software development life cycle in industry . 3 years of postdoctoral experience performing extensive in depth statistical data analysis of large scale gene expression , DNA methylation , genotyping , microarray and NGS Next Generation Sequencing data sets . Excellent communication and management skills with 5 years of experience as a software team lead . Skills Programming languages : Java , Python , C C , R Bioconductor , Shell script . Bioinformatics tools : UCSC Genome Browser , Genepattern , Cluster JavaTree , Circos , CLC Genomics workbench , Expander , GeneSpring , Cytoscape , GSEA , NIA Array Analysis tool , SAMtools , GATK Databases and infrastructure : mySQL , MongoDB , Hadoop Web applications : JavaScript , HTML Operating systems and tools : Git , Maven , SVN , Eclipse , JIRA , Stash , Windows , UNIX , Linux , MAC OS , CPLEX , ClearCase , Dreamweaver , Vim . Specialties : Software design and development , programming , machine learning , data analysis , statistics , bioinformatics , next generation sequencing , microarrays , algorithms , DNA methylation , epigenetics . Technologies :
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Science Lead . . . Technologies :
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Associate Director , Bioinformatics Computational Biology . . A diversly trained computational scientist that is driven by the goal to improve human health by creating and using new computational technologies with high throughput molecular data . I have 10 years of experience working in ' omics ' era data science in both academic and industry settings . Currently , I work as a bioinformatics computational biologist , contributing to the drug discovery process with advanced analytics of internal and external datasets , identifying or developing new analytical methods , and collaborating with lab scientists to advance drug discovery programs . My previous roles as a bioinformatics research scientist have entailed a wide range of NGS data analysis and methods development projects .. Technologies :
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Associate Director , Bioinformatics . . . Technologies :
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Automation Scientist . Oxford Nanopore Technologies is a multidisciplinary company employing nanopore science , molecular biology , electronics , informatics and more to deliver sequencing platforms in fully scalable formats from pocket to population size genetic sequencers . As an automation scientist I work on development , optimisation and validation of automation solutions for ONT sequencing kits . . Driven and committed biotechnologist with research and industry experience . I 've worked in microbiology , molecular biology , computational biology and clinical diagnostic laboratories . My special interests are in genetics , metabolism , systems biology , and microbiology .. Technologies :
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Higgins Professor of Natural Sciences . . . Technologies :
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Scientist II . Protein Biochemist Structural Biology Group . I am a protein biochemist with over ten years of combined doctoral , postdoctoral , and industry research experience in the life sciences . I have extensive knowledge of protein biochemistry and molecular biology methodologies with specific expertise in the following : Protein expression and purification bacterial and mammalian cell culture Antibody engineering Protein characterization , including biophysical and binding assay analysis SEC MALS , DLS , DSF , BLI Mammalian cell culture and cell based assay development Lentivirus production and viral neutralization assays pseudotyped SARS2 , Ebola , and HIV Design and implementation of in vivo studies for immunological vaccine characterization Construct design , mutagenesis , and molecular cloning Single molecule fluorescence microscopy . Technologies : SLS DLS;BLI;DSF
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antibodies;proteins;characterization;engineering;interaction;structure
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Senior Lecturer in Computational Biology Machine Learning . . Kevin Bryson is an Senior Lecturer in Computational Biology Machine Learning in the University of Glasgow School of Computing Science . His lab focuses on applying computational , mathematical and statistical approaches to understand clinically relevant biological systems with the aim to integrate diverse data sources and techniques to develop models that can diagnose and stratify diseases . He is the Director of the MSc IT and SD degree programmes . He teaches machine learning deep learning , Java programming and databases .. Technologies :
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Manufacturing Science Technology Scientist . Improved and developed bacterial and viral vaccines for global health and immunization programs run by WHO GPEI , PAHO and UNICEF for polio , tetanus , diphtheria , besides bacterial products for immunotherapy of cancer . Provided troubleshooting solutions related to deviations and formulation challenges . Designed experimental plans with a close look on practical work based on scientific guidelines aiming at addressing shortage on supply of vaccines worldwide . I specialize in formulation , drug product development , manufacturing and physicochemical preclinical characterization of vaccines , novel drug delivery systems for targeted and controlled release of active small and large molecules via oral , intravenous and intramuscular administration routes . I have experience with scale up and technology transfers . Additionally , I perform PK BE data analysis , modelling and simulations . Specialties : . Formulation of viral vaccines and bacterial products for cancer . In vitro in vivo correlation IVIVC and pharmacokinetic PK predictions . Pre and clinical data analysis , statistics , modelling and simulation . Design of experiments DOE , Quality by Design QbD . Technology transfer from pilot to pivotal phases and CMOs . Analytical method development e. g. U HPLC , M DSC , TGA , PXRD , rheology , DLS , and others . Formulation of microparticles based on natural and synthetic polymers . Design of lipid based formulations for oral delivery of poorly soluble drugs . Development of liposomes for targeting of atherosclerotic plaques for therapy and imaging . Physicochemical , toxicological and kinetics characterization of novel drug carriers . Writing of scientific material in English , French and Portuguese . Teaching on Pharmacology , Pharmacy Practice , Quality Control , Medicinal Chemistry , Cosmetics and English . Technologies : SLS DLS
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biologics;carriers;characterization;developing;formulation
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Senior computational biologist . . A computational biologist with extensive wet lab experiences . A goal oriented problem solver by developing custom made computational pipelines . Interested in using integrative omics analysis to identify therapeutic targets and biomarkers , then designing and doing experiments to validate .. Technologies :
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Scientist , Computational Chemist . Computer Aided Drug Design Structure Based Drug Design Ligand Based Drug Design Docking Protein Ligand Interactions Pharmacophore Modeling Virtual library screening Machine Learning drug discovery . Six years of Pharmaceutical Industry research expertise , an EU Marie Curie Individual Fellow in Computational Drug Design and Computational Chemistry , and Ph.D. Candidate with two years postdoc experience . Experience and competence in protein protein docking , structure ligand based drug design techniques , Chemo informatics with a strong background in modern computational chemistry . Committed team player , flexible and reliable with excellent communication .. Technologies :
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Scientist . . My work at MSD for 19 years started as a senior Operator in the manufacturing department . I performed down stream purification processes in a cleanroom environmetal under strict GMP conditions . . After more than 3 years of work in the manufacuring facility , I worked as a lab technician . In this function methodology and troubleshooting were the main goals . In this position I expanded my knowledge about chromatographic techniques by performing troubleshooting activities and process characterization studies including the analytical analyses sush as HPLC analysis using Chemstation , ELISA , SDS PAGE , and 2D electrophoresis . . During the years I developed myself to an associate scientist level and have been employed within the PDC Process Analytics department . Main activities of the PA department is providing intermediate process support to the USP and DSP project teams using different analytical methods to determine charged variants , aggregates as well as process related impurities . Good scientific knowledge with regards to HPLC , Empower and ELISA methods was obtained , as well as in depth process knowledge to facilitate the analysis of process intermediates , obtained from monoclonal antibody process development studies . During this function I have various contacts within the local and global network , in order to provide appropriate analytical support and scheduling of the samples requests . Furthermore I have been . responsible for the automation of analytical methods using the Tecan Freedom EVO high throughput and the Waters Patrol automated analysis system on line sample analysis , to contribute to continuous processing . I am a flexible person with extensive knowledge of downstream processing as well as analytical methods . . Technologies :
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Bioinformatician . Clustering of cancer transcripts . . Technologies :
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Scientist IV , Biotherapeutics . Mass Spectrometry Lab , Biotherapeutics Department Mass spec analysis of intact mass , deglycosylated , reduced , limited digestion and peptide mapping of antibodies , antigens and fusion proteins . Proficient in characterization studies of biologics at forced degradation conditions and gaining expertise in structural analysis of antigen antibodies epitope and paratope mapping by HDX MS . . Motivated , energetic and driven professional with 20 years experience in Pharma . Current role focusing on protein and antibody characterization by HRMS , proficient in intact analysis , peptide mapping , forced degradation studies liabilities identification . Gained significant experience in using HDX analysis for epitope and paratope mapping .. Past roles focused on in vivo PK and bioanalysis . Provides bioanalytical support for various stages research projects by LC MS MS for small molecules and biomarkers . Highly knowledgeable and experienced with bioanalytical method development and validations , extensive experience with small molecules and biomarkers . LIMS systems : IDBS e Workbook BioBook , Watson , GeneData Biologic Proficient in PMi and HDExaminer . Biologics team representative for several early stage discovery projects . Passionate about applying technology to practical applications in a high energy environment . Expertise in organizing executing programs , both science and non science related . Strong oral and written communication skills . Good interpersonal and team work skills .. Technologies :
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biologics;characterization;stability
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Scientific Group Leader , Target Structural Enablement . . I specialize in protein purification and structure determination by cryo electron microscopy cryo EM .. Technologies : CryoEM
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proteins;structure
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Protein Scientist I . . PROFESSIONAL SUMMARY Highly motivated , detail oriented research scientist with 15 years of research experience in protein purification and characterization , molecular biology , virology , immunology , mammalian cell culture , and experimental mouse models Actively involved in expression , purification involving AKTA systems and biochemical characterization of various recombinant proteins including protein domains and enzymes from bacterial or insect cells in a highly collaborative environment within tight deadlines Developed new methods and improved existing purification methods to generate higher and better yields of challenging proteins Eminent virologist with years of BSL 2 2 experience in viral manipulation , infection , growth , and isolation as well as performing viral titer assays and quantification of virus expression by qPCR Years of expertise in cell line development from vector construction , lentivirus production and transduction , cell culture maintenance and clone screening to cell line characterization Experienced in molecular biology tools including DNA RNA isolation , Northern Southern blotting , PCR , qPCR , DNA sequencing and analysis of sequence data , site directed mutagenesis and CRISPR Cas9 mediated genome editing Extensive experience in cell signaling and mechanism of action studies using various biochemical and immunological techniques like Western blot , immunoprecipitation , ELISA , flow cytometry including FACS and immunofluorescence using confocal microscopy Excellent organizational skills and the ability to prioritize and execute work on multiple , complex projects in diverse areas simultaneously Great ability to build collaborative work relationships required for timely completion of research projects Outstanding written , oral and interpersonal communication skills Consistently earned praise for the ability to lead , motivate and develop associates as well as generate high level of energy and enthusiasm among staff members . Technologies :
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proteins;characterization;expression
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Independent Life Science Consultant . perform project management . ensure strategic re focusing of programs e. g. for start ups or spin outs . identify the best opportunities for their technology know how as well as in or out licensing opportunities . develop focused and result driven scientific programs . identify the right partners to make outsourcing work . help create and or grow the team . create a corporate culture introducing a strong result oriented vision focused on the final product . perform due diligence and business intelligence for investors and or Companies . Peter Tomme graduated in 1985 as a Bachelor in Chemistry from the University Ghent , Belgium , where he also earned his PhD in Biochemistry in 1991 . Today , he is an independent Pharma Biotech Management Consultant . In 2006 , he joined TiGenix as R D Director where he was responsible for product and pipeline portfolio development until the end of 2010 . He was part of the team that successfully developed ChondroCelect , the first Advanced Therapy Medicinal Product approved by EMA . In 1999 he was co founder and R D Director of Galapagos where he established the technology platform and target discovery in a large number of therapeutic areas . Peter also served on the Management Teams of both Companies and was part of the teams that successfully concluded the IPO of Galapagos and TiGenix , respectively . Prior to joining Galapagos , he was a Director at Tibotec and part of the drug discovery team for HIV and HCV . He started his professional career in 1994 at the University of British Columbia , Vancouver , Canada as a Research Staff Member specialized in Protein Engineering and the development of pharmaceutical and industrial proteins . Peter is also co founder of CBD Technologies and was involved in the establishment of Arcarios , a young drug development company for bone and joint diseases . Specialties : Biotech R D , therapeutic product development biologicals , cell therapies , general drug discovery , translational medicine development , protein engineering , genomics , stem cell research development , CMC and process improvements , general and operational management . Technologies :
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Analytical Scientist . Bioneer : FARMA is a business unit of Bioneer located at the Department of Pharmacy , University of Copenhagen with many years experience in all aspects of drug development and characterization . We provide analysis , pre formulation , formulation , as well as in vitro and in vivo evaluation , of both biological and small moleculare drugs . We specialize in oral drug delivery and have developed a range of in vitro models simulating the behavior of drugs and drug products in the gastro intestinal tract . We use cell culture models to assess drug permeability and absorption mechanism . . Cand.scient in nanoscience , PhD in biophysical chemistry . Formulations drug delivery Lipids surfactants excipients Proteins peptides Biomolecule interactions HPLC , FPLC , LC MS Scattering techniques : NR , SANS , SAXS . Technologies :
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biologics;carriers;peptides;proteins;characterization;formulation
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Principal Bioinformatics Scientist . . I am interested in solving computationally challenging data science problems from biology and medicine using machine learning , statistics and algorithms .. Technologies :
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Postdoctoral Research Fellow . Small molecules targeting RNA triple helix and structural elucidation using CryoEM . During my undergraduation , I enjoyed learning chemistry in close relation with biology and was placed among top 15 students out of several hundred . During Master s at Department of Chemistry , Central college campus , Bangalore University , Bangalore , I got strong theoretical and practical training in different aspects of chemistry , which include broad area of inorganic , organic , physical and analytical chemistry in the first year . I specialized in organic chemistry during the second year . In 2011 , I cleared Council of Scientific and Industrial Research Junior Research Fellowship CSIR JRF , securing all India ranking 69 in chemical science . Later , as junior and senior research fellow at Department of Chemistry , Indian Institute of Technology , Kanpur IIT Kanpur , I worked on rational design and development of novel metalorganic framework and lattice inclusion compounds and attended an international summer school on Topological Methods for Expert Systems in Materials Science at Samara State University , Samara , Russia . In 2016 , I joined Nanyang Technological University , Singapore to pursue my doctoral degree under the supervision of Asst . Prof. Chen Gang . My graduate research interest was focused on i the rational design and synthesis of duplex binding Peptide Nucleic Acid dbPNA monomers displaying sequence and structure specific binding to RNA duplex through the Hoogsteen hydrogen bonding and ii fluorescent PNA monomers , which can be used as a diagnosing tool to understand the nucleic acid microenvironment and structural polymorphism that prevail in the nature . As a postdoctoral research associate at Department of Chemistry Biochemistry , University of Notre Dame , I am currently working on small molecules binding to and regulating the activity of the MALAT1 triple helix and other biologically important RNA triple helices . My research interest also focused on elucidating the three dimensional structure of the MALAT1 triple helix in complex with small molecules and proteins using Cryo electron microscopy techniques . Overall , the 10 years of my research journey helped me to develop many skills in different fields of science from synthesis , characterization , to applications with an opportunity to mentor more than twenty students for their masters under graduate dissertations .. Technologies : CryoEM
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nucleic acids;small molecules;interaction;structure
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Sr Manager Analytical Development Molecular Bio Assays . Vaccines Process Analytical Development VPAD Janssen Vaccines Leading a Team of 10 dedicated Scientists , Associate Scientists Lab Technicians Development of Molecular Bio Assays and Microbiological Methods for Release , Stability , Characterization and Process Development Qualification , Validation , Verification of Analytical Assays according to Regulatory Guidelines Coordination and leading of Assay Transfer from Development to GMP Quality Control QC Scientific support of Quality Control QC labs Quality Deviation Management Health Authority Inspections Product Characterization Comparability AD QC Technical Integrator for Cell Gene Therapy Products . Talent wins games , but teamwork and intelligence win championships . Michael Jordan . Technologies : CryoEM
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biologics;characterization;stability
|
Scientist . . . Technologies :
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Scientist . . Ph.D. study and postdoctoral experience in single particle cryo EM research , image processing and 3D reconstruction Extensively trained in membrane protein biochemistry , molecular cloning , yeast genetics and nuclear magnetic resonance NMR spectrometry . Technologies : CryoEM;NMR
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membrane proteins;structure
|
Biomathematician Biostatistician . . A statistician and computer scientist with many years of working experience in developing and applying statistical methods and bioinformatics tools in the fields of structure bioinformatics , statistical genomics , cancer genomics and gene therapy .. Technologies :
| null |
Senior Research Associate I . . M.Sc . in Molecular Biotechnology . Natural Sciences enthusiast . Working on protein degradation .. Technologies :
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molecular glues;interaction
|
Research Investigator . . My primary field of interest is protein biochemistry and structural biology . During the course of my career , I have extensively studied structure function relationship of both soluble and membrane proteins in bacterial and mammalian cells . By working in these core specializations , I have amassed invaluable experience in molecular cloning , protein engineering , protein purification , assay development , cell culturing bacteria , insect , and mammalian cells , X ray crystallography and cryo electron microscopy . In addition , I m well versed in thorough functional analysis of proteins using a multitude of biochemical , biophysical , and immunochemical tools .. Technologies : Xray;CryoEM
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membrane proteins;proteins;engineering;structure
|
PhD Researcher . . PhD Student at University of Bristol from September 2019 Keen to build tools for biomolecular design and functionalisation of proteins . wet and dry experimentalist , interdisciplinary enthusiast . Technologies :
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Senior Machine Learning Deep Learning Scientist . . Recovering academic and freelance scientist . Interested in genomics , bioinformatics , and machine learning .. Technologies :
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Postdoctoral Research Associate . . Experience in cryogenic electron microscopy cryo EM Familiar with molecular simulation and modeling Having basic programming skills . Technologies : CryoEM
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proteins;structure
|
Senior Scientist . Protein Purification and Chemistry . Protein Drug Development Protein Chemistry Protein Stability , Protein Analysis , Protein Purification , Chromatography , Filtration , Protein Formulation , Tech Transfer Lab to Pilot , Project Management . Technologies :
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proteins;characterization;expression;formulation;structure
|
Senior Director , Discovery Bioinformatics . . I develop methods to use health information to guide therapeutic strategy . The goal is to personalize treatments , rather than treating cohorts of patients with a standard care and hoping some percentage of them respond . This includes utilizing cloud based storage to house big data , state of the art machine learning algorithms , and massively parallel computing , to build accurate and robust predictors , as well as web technologies to power intuitive exploration and reuse of those predictors .. Technologies :
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Director , Digital Transformation Sciences . . . Technologies :
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Senior Scientist . Bioneer A S is a small CRO and we also deliver recombinant proteins for our customers . I 'm responsible for the protein purification , protein characterization and product development in the protein chemistry area . For protein production we use different prokaryotic expression systems as well as mammalian cell systems CHO and HEK293 cells . Some of my larger projects the recent year has been with in protein purification process development , technology development and protein pre formulation studies . For protein analytics we mostly used SEC HPLC , RP HPLC , SDS PAGE , capillary electrophoresis CE SDS and cIEF on a Sciex PA800plus . Bioneer A S also deliver services in : Human disease models Molecular histology and detection Drug formulation and characterization . Specialties : Protein purification process development . Protein chemistry and enzymology . Enzyme kinetics and assay development . Protein design and rational protein engineering . Recombinant protein expression in E.coli , Pichia pastoris and Aspergillus oryzae . Glycoside hydrolases . Protein formulation and Protein stabilization . Solubilization of inclusion bodies and protein refolding . Protein crystallography . Studying metal ions in proteins bioinorganic chemistry . Protein structure function analysis . . Technologies : Xray
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proteins;characterization;expression;formulation
|
Head of Bioinformatics . . . Technologies :
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Research Engineer . Taking care of the NanoImaging Core Facility at Institut Pasteur for Cryo EM applications Sample Freezing , SPA , Cryo ET , lamellae Milling , and provide Cryo EM Training Course . Work on Glacios Cryo TEM , Titan Krios G3i Cryo TEM , and Aquilos Cryo FIB Systems . . Technologies : CryoEM
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Bioinformatics Scientist . . Bioinformatics Computational molecular biology Data analysis Algorithm development Machine learning Statistics C Java Bash R python . Technologies :
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Facility Manager . . . Technologies : CryoEM
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Research Associate in Bioinformatics PostDoc . . I have more than 10 years experience in data analysis and developing efficient computational models algorithms for different computational problems . My general interest include Numerical Analysis , Data Modelling , Data Management , Data Statistics Analysis , Algorithms Design , Analysis Optimisation , Complex Network and Computational Systems Biology . I have 2 degrees M.Eng . and M.Sc . in Computer Science and obtained my PhD in Mathematics . I can help you with : Algorithm Development Algorithm Analysis Optimization Mathematical Statistical Models Numerical Analysis Data Analysis especially large scale complex datasets modeling and analysis Statistical Methods Tools e.g. , Nonparametric Statistics , Bayesian Statistics , Probabilistic Graphical Models , Hypothesis Test Design , etc . Machine Learning , Data Mining Pattern Recognition Programming and Software Developing High proficiency in mainstream programming languages , such as C C , Matlab , R , Java , SQL , Python Bioinformatics Systems Biology Teaching Tutoring Scientific Presentation Interdisciplinary Collaboration I am an experienced programmer primarily Matlab and R , and also familiar with other programming languages such as C C , Java , Python , Visual Basic , SQL and etc . . I am also experienced in large scale data analysis and data management . I am familiar with different operating systems e.g. , Unix Linux , Windows , Mac OS , statistical models tools and the bioinformatics resources tools e.g. , David , ENCODE , Ensemble , GSEA , Cytoscape , The relevant Matlab toolboxes and R packages . In addition , I have a lot of teaching experience e.g. , giving lectures , delivering tutorials labs , marking , supervising , etc . . In summary , I have demonstrated skills in writing , programming , publication and presentation . From the training courses during my studies and my employment history , I also gained a lot of communication , collaboration , teamwork , management and leadership skills .. Technologies :
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Sr . Informatics Engineer . All things AWS . . Extensive experience in statistical analysis and data visualization . Solid understanding of software development life cycle processes including requirements gathering , analysis and design , development tools and technologies , release and version control .. Technologies :
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Scientist . . Highly focused and results driven medicinal organic chemist with experience working as part of a team in academic and industrial laboratories . Currently working in drug discovery developing novel ligands that bind to E3 ligases for eventual application in PROTAC design . Applying both structure and ligand based drug design strategies to progress HTS and virtual screen hits to the clinic . Completed PhD investigating autocatalytic reactions , their mechanisms and applications . Generated project ideas which led to successful experimental results culminating in 3 first author papers . Presented scientific research through posters and oral presentations at international conferences , strengthening my communication abilities . Leadership skills from supervising undergraduate and graduate students .. Technologies :
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molecular glues;small molecules;developing;structure
|
Machine Learning Research Intern . Startup backed by investors including a16z , GV , Obvious Ventures and Lux Capital , out of Harvard s Church Lab , working on building ML models towards sequence prediction and design of adeno associated viruses AAV for gene therapies . Exploring SOTA DL approaches in protein representation learning transformers , bayesian optimization on novel sequence structural representations MSAs , cryo EM for capsid engineering . . Hey , I 'm Seyone , an 18 year old working at the intersection of machine learning and biochemistry . This summer , I 'll be working at Dyno Therapeutics , an a16z backed biotech startup out of Harvard 's Church Lab , at the intersection of ML guided protein design in NYC . Alongside my work there , I 'm on the open source developer team for DeepChem , a project aiming to build scientific drug discovery tools using machine learning , based out of Stanford University Last summer , I interned on the R D team at Nurix Therapeutics , a public biotech company in San Francisco aiming to discover immuno oncology drugs that harness the body s natural process to control protein levels . Previously , I work on researching cutting edge applications for drug discovery using machine learning , as a research intern in the Matter Lab at the University of Toronto . I was supervised by Prof. Alan Aspuru Guzik . My work is supported by the Emergent Ventures Fellowship from Dr. Tyler Cowen and the Thiel Foundation , alongside the Masason Foundation . In the past , I 've worked at Integrate.ai , building out SaaS AI products for Fortune 500 companies . When I 'm not working on research or programming , I like to go biking , hiking and cook . Please feel free to contact me at seyonec gmail dot com , and check out my website at https : www.linkedin.com redir phishing page url https 3A 2F 2Fseyonechithrananda 2ecom 2Fabout . Technologies : CryoEM
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Graduate Student Ward Lab . I investigate the structure function of membrane proteins . . I am a graduate student at The Scripps Research Institute , with an emphasis in Structural Biology . I use Cryo EM and Mass Spec to investigate the structure function of membrane proteins of clinical significance . By combining structural and chemical biology , I aim to develop novel therapeutics for rare diseases . Before graduate school , I taught high school math and science . Through this experience , I developed strong interpersonal and management skills that I continue to implement in the laboratory . I also have extensive experience as a student leader . As an undergraduate , I represented over 20,000 students as an elected member of the academic senate and as a lobbyist in Sacramento . I 'm always eager to learn from others with experience in science , education , and related fields . I am also deeply interested in police monitoring , non profit management , and the biotech industry . I can be reached through my profile and at leonandre22 gmail.com .. Technologies : CryoEM
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membrane proteins;structure
|
Director Of Bioinformatics . . Experienced genomics and bioinformatics scientist with a demonstrated history of working in the research industry . Extensive experience applying next generation sequencing to multidisciplinary fields such as oncology , large scale population genomics , evolutionary and developmental biology . Experience in both wet lab techniques and computational methods . Proven leadership experience in building a 10 people bioinformatics team for building software tools for high quality analysis of NGS data . I have led several high impact projects that have resulted in publications in top tier journals .. Technologies :
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Principal Scientist II . Oncoimmunology ML Deep learning . I am leading the bioinformatics algorithm development team at Roche Pleasanton , CA . . Technologies :
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Research Data Analyst . Developed RNA ranker , a tool for ranking therapies based on RNA overexpression , using R Shiny for Treehouse Childhood Cancer Initiative . Create tumor board presentations from pediatric RNA Seq data for clinical partners at Stanford , UCSF , British Columbia Cancer Agency , and Nationwide Children s Hospital . Oversee undergraduate researchers in reviewing publications and variant databases COSMIC , cBioPortal , CIViCdb to generate an internal database of variant pathogenicity . . I am a data scientist with a background in mental health and therapy . I combine my analytical background as an Applied Behavioral Analyst with my passion for computer programming . My interest in Artificial Intelligence development gave me the impetus to begin Udacity 's Machine Learning Engineer Nanodegree program . By learning how to code in Python and use machine learning tools like Scikit learn , pandas , and TensorFlow I hope to develop tools that will increase human productivity and well being . . Technologies :
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Senior Principal Scientist . . My research interests encompass pharmacology , biochemistry , enzymology , chemical and structural biology . In particular , enzyme kinetic and chemical mechanisms , the study of small molecule target engagement , mechanism of action , binding kinetics , biophysical biochemical characterization , and residence time , in the hits to leads and leads optimization stages . I have significant experience in kinase and enzyme drug discovery , as well as targeted protein degradation . I enjoy applying multidisciplinary approaches to solve challenging drug discovery issues . Specialties : Biochemical and Cellular Assay development , Molecular and Cellular Pharmacology , Protein biochemistry , Enzymology , Biophysics , Targeted Protein Degradation . Technologies :
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enzymes;molecular glues;proteins;small molecules;characterization;interaction;screening
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Bioinformatician . . A scientist with academic research experience of over 7 years . I specialize in the genomics and epigenomics of cancer development . My primary research interests are in Myeloid and Lymphoid malignancies . I also develop and contribute to open source computational tools for genomic data analysis . Research interests : Bioinformatics , Leukemia , Personalized medicine , PROTACs . Technical skills : R , Rust , Python .. Technologies :
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molecular glues;developing
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PhD Candidate . Working under Dr. Wen Jiang , studying tau , alpha synuclein , and prion filament structures associated with neurodegenerative diseases including Alzheimer s and Parkinson s using cryo electron microscopy cryoEM and cryo electron tomography cryoET . Hockmeyer Hall of Structural Biology Department of Biological Sciences . Graduate student in the field of biophysics and structural biology . Research focus is utilizing cryo electron microscopy to study neurodegenerative filaments . Technologies : CryoEM
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idps;structure
|
Postdoctoral Researcher . . I 'm a Basel based researcher with an interdisciplinary background in biotechnology and microfluidics . I 'm currently working on a droplet based screening system to identify antibodies against new variants of the corona virus . . During my PhD and my PostDoc I have been leading intradepartmental projects and collaborations with companies such as IBM and MEMO Therapeutics . . Technologies :
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antibodies;screening
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Research Development Team Lead . Research and development of efficient and high quality deep learning methods for image processing . . Experienced Senior Research Associate with a demonstrated history of working in the higher education industry . Skilled in Mathematical Modeling , Bioinformatics , Computer Science , Statistical Modeling , and Pattern Recognition . Strong research professional with a Doctor of Philosophy PhD focused in Computer Science from Imperial College London . . Technologies :
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Senior Bioinformatics Cloud Engineer . Second Genome leverages its proprietary drug discovery platform to identify effective peptides , proteins , and small molecule therapeutics that can address unmet medical needs . I architected a new AWS ETL automated pipeline including smart orchestration to ingest public and proprietary data to generate genomic , peptide , RNA seq , or clinical derived features . Patent pending . Collaborated with wet lab scientists and product managers to architect new AWS bioinformatics workflows and communicated frequently about the project progress , prioritization , and roadblocks . Built , optimized , and maintained microservices to automate the execution of common microbiome informatics tasks : Nucleotide Sequence QC : adapter trimming , rRNA , host , and low quality reads removal . Taxonomy identification : sourmash and metacache Functional genes identification : diamond , using kegg and biocyc DB as a reference Genomic assemblies spades and megahit Build CI CD with pytest , AWS codebuild , and infrastructure as code to foster agile software development . Build protein insecticidal toxicity models using public data and features inferred from protein sequence , using MemeFimo , HMMER , USearch , PlasFlow , and iFeature features . Used SHAP values and intrinsic feature importance to infer the biological reason for high scoring proteins Benchmark of our internal Scikit learn , Jupyter ML workflows vs BioDiscML for proprietary Colorectal Cancer CRC datasets . . Courageous computational biologist , software engineer and data scientist , looking constantely to expand technical and scientific knowledege and answer complex biological questions . With degrees in computer engineering and computational biology . Have studied the integration of computation and biology in different questions , doctoral studies focused on human and environmental microbiomes ranging from human skin to marine mammals , air , water , soil , and agriculture . Seeking to apply bioinformatics , computational biology and machine learning methods to model complex microbiological systems , including microbial communities networks and microbe environment interconnections . Applying analytical skills to topics highly relevant to society with great economic impact , most notably agriculture and human health .. Technologies :
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Doctoral Candidate , pharmaceutical and medicinal chemistry . drug design and synthesis peptide chemistry LC MS and NMR analytic antiviral drugs and proteolysis targeting chimera PROTAC technology Dozent f r Arzneimittelanalytik . Doctoral Candidate at Rheinische Friedrich Wilhelms Universit t Bonn Registered pharmacist M.Sc . in drug design at Goethe Universit t Frankfurt am Main State examination in pharmacy at Goethe Universit t Frankfurt am Main . Technologies : NMR
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molecular glues;peptides;developing
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Scientific Researcher . Researcher working with electron cryo microscopy Cryo EM at Stockholm University studying the evolution of the mitochondrial ribosome . . . Technologies : CryoEM
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structure
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Assistant Professor . 1 Design , conduct , interpret and report on Single cell and bulk transcriptomic , single cell epigenome , and proteomic studies that lead to discovery of biomarkers and therapeutic targets . High throughput Single cell and bulk transcriptomic , single cell epigenome , and proteomic data management and analysis with R , python , and SQL . 2 Supervise Technicians to conduct lung immune inflammation and fibrosis research with both in vitro and in vivo models , such as bleomycin and LPS induced lung injury models , genetic conditional knockout and lineage tracing mouse models , 2D and 3D AT2 cell culture , FACS based cell subpopulation separation , Single cell RNA seq and ATAC seq , mRNA mediated vesicular therapeutic approach . 3 Manage multiple research projects , responsible for independent experiment design , execution , and reporting , such as the determination of the role of growth hormone receptor in AT2 cell niche , regeneration , and differentiation , mechanism of CCXCL14 and Tbx4 in regulating pulmonary fibrosis . 4 Apply new NIH grant , support NIH funded projects . 5 Present data both within institution and external conferences . 6 Collaborate with other scientists to conduct research within institution and external organizations . . Coming from a medical background , with 15 years experience in Research and Development life science Computational biology studies and 10 years experience in gene expression analysis . Ph . D expert in lung immune and degenerative diseases . Specialized in both in vivo and in vitro disease modeling systems lung injury and repair , aging related cellular and molecular mechanisms of fibrosis , stem progenitor cells , mesenchymal immune cell interaction , cellular subpopulations and transcriptional regulations , extracellular vesicles and etc . Quantitative bulk RNA seq , single cell RNA seq ATAC seq , CRISPR screen , and proteomic analysis DE , GO , clustering , data visualization , cellular velocity , delineation trajectory by machine learning etc . . Proven ability in computer programing , including R Bioconductor , MEFISTO , Seurat , Signac , edgeR , DESeq2 , Cuffdiff2 , ggplot2 , dplyr , tidyr , tidyverse and etc , python muon , panda , scanpy , numpy , matplotlib , gseapy , CRISPR seq , and etc , SQL , Jupyter notebook , as well as git version control systems github and etc . Hands on experience with HPC cloud based Linux system . Confocal Imaging Zeiss , Leica confocal Fluorescence , immunohistochemical techniques IF , IHC , ISH , RNA scope , multi parameter FACS , protein expression analysis Western blot , ELISA , genetic engineering CRISPR Cas9 , and statistical analysis . Proven scientific track record in systemic and computational biology research including multiple publications and journal review experience . Excellent scientific communication skills exemplified by various papers including first authored papers on Science Advance , Cell Report , and JCI , PubMed : https : www.ncbi.nlm.nih.gov myncbi ting.xie.1 bibliography public , presentations , and grant experience . Patented discoveries in lung disease . Proven ability to work independently and as a team player to collaborate with experimental scientists . Proven ability in project management , supervision , and mentoring of undergraduate students , junior postdocs , and technical staff . Skill : Single cell RNA seq ATAC seq , Spatial genomics , Proteomics , Epigenomics , multi omics Data Analysis , Python , R , SQL , Pyspark , SparkR , GATK , Hail , Linux Shell , Docker , Virtual Box , Bioinformatics , cloud based HPC Linux computing Lung Research , immunology , molecular biology , genetics , stem cells , mesenchymal cells , matrix biolog Confocal and EM imaging , 2D and 3D cell culture , Flow cytometry , Western Blotting . Technologies :
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Senior Research Scientist . . As appears on paper , I am an experienced and skilled biochemist with competencies spanning targeted metabolomics , evolution , molecular biology and biochemistry . Beyond paper , I am a proficient and engaging spirit with contagious enthusiasm . I have always enjoyed compiling a huge amount of creativity into my workflow often bending the classical ways of experimental setups . Scientific key areas Protein chemistry Pathway discovery Enzyme design and optimization Technological key areas Heterologous expression and purification protein , metabolites Liquid chromatography and mass spectrometry HPLC , LC MS , LC QTOF MS MS Synthetic lipid systems Vesicles , Nanodiscs , microsomes . Technologies :
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membrane proteins;engineering;expression
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Senior Research Scientist . . I am passionate about research that is relevant for pharmaceutical industries and public health . I am primarily experienced in structural biology and protein formulation . I have been working with different protein drugs and investigating their stability using variety of methods . During my personal and academic life , I became independent , very organized , and responsible . I adapt easily to a new work environment and I am very interested in working in multidisciplinary and multicultural teams . I am highly interested in learning new subjects that could aid me in becoming more versatile in my profession .. Technologies :
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proteins;formulation;stability;structure
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Scientist . R D . I am a molecular biologist passionate about deciphering the function of proteins with a combination of structural and biophysical techniques . With previous pharmaceutical and industrial experience , as well as more than 7 years of research on challenging topics , I have gained profound expertise in gene cloning , protein expression , purification and characterisation . Throughout my previous work , I have always enjoyed trouble shooting and keeping my tasks and environment organised . I am familiar with working on parallel projects , where planning and prioritising is a must in order to meet deadlines . I love to collaborate with partners so that together we could reach a greater goal that can not be realised alone . I value creative solutions and enjoy learning new things . I approach problems in a systematic , meticulous manner . My colleagues often describe me as positive , supportive , resourceful and trustworthy . I look forward to using my knowledge and analytical mindset in my future job where I can further develop myself with new input and challenges . Should there be any questions , please feel free to contact me via LinkedIn or by email wangshu.jiang.b gmail.com . . Technologies :
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proteins;characterization;expression;structure
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Machine learning Software Scientist . In collaboration with the Swiss National Supercomputing Centre CSCS and the Swiss Data Science Center SDSC I am designing a new data processing architecture to process and compress automatically the large amount of data 40 GB s collected at the macromolecular crystallography beamline . . Machine learning computational thinking molecular modelling programming scripting data analysis data visualization scientific communication I am a machine learning scientist with a background in molecular modelling and machine learning . I love working in talented teams to solve complex problems using innovative technologies . . Technologies :
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Senior Research Associate II . Generation of stable cell lines using CRISPR Cas9 and lentivirus transduction to validate the compounds developed by the company . Establish and perform in vitro cellular assays for target validation and compound testing . Generation of stable expression iPS cells using lentivirus and differentiation . I am a fast learner in a scientific environment , and proactive in addressing problems , with consistent follow through to meet goals . I also approach all tasks in an organized , methodical fashion and keep well organized , complete lab notes . I have strong work ethic and enjoy working in a fast paced , international , and multidisciplinary environment . Thanks to my experience in various laboratories and biotech companies , and thanks to my current position at CZ Biohub and my former position at Cairn Biosciences , I developed the following technical skills : . Molecular Biology : Cloning , Primer design , PCR , gel electrophoresis , BLAST , Nanodrop , DNA extraction . Cell culture , stable cell line generation , FACS . Mass spectrometry sample preparation and analysis using Perseus . High Content Screening : Optimization , use of lab automation liquid dispenser , Titertek plate washer , Biomek , analysis . Fluorescence and confocal microscopy . Digital droplet PCR analysis : determination of copy number variation . I have been also involved in the lab organisation of all the organizations I worked in . . Technologies :
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Chief Scientific Officer at Biotalys . . Nanobody Explorative Technologies NExT towards the next generation Nanobodies . Management of a Nanobody technology innovation portfolio . supervision of a team of technology oriented project leaders . outlining technology innovation strategy . managing academic and industrial collaborations . . Technologies :
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antibodies;developing
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Senior Manager , Principal Scientist . . PROFESSIONAL STATEMENT Blends an extensive and accomplished academic background with successful industry experience to provide proven exceptional critical thinking , problem solving , and technical skills to employers . Expertise spans areas that include immunology , molecular biology , cell signaling , autoimmune disease , immuno oncology including CAR T cell therapy . Industry experience working in the areas of early research , lead identification preclinical , translational and QC clinical has been acquired in organizations at various stages of maturation from early Innovimmune to growing ICOS Corp to mature BMS , Novartis , Celgene which has provided me with a great variety of views of the drug development process and the challenges involved . KEY SKILLS Extensive molecular cloning experience and DNA RNA PCR based methods . Substantial flow cytometry expertise 13 colors most familiar with LSRII and LSRFortessa machines , intracellular , phopsho flow , sorting , proliferation , viability , etc . Vast array of cell based assay techniques see attached CV below for exhaustive list . Considerable background in a multitude of cell culture techniques and cell types , as well as co cultures . Transient and stable transfections plus viral transductions . Variety of in vivo mouse skills including induction of autoimmunity . Successfully led lead ID for an oncology drug program . Excellent written and presentation skills . AREAS OF EXPERTISE Immunology Molecular Biology Cell Biology Cell Signaling e.g. PI3 K , MAPK , NFkB , IP3 DAG , etc Chemokines Autoimmunity GPCRs NRs In vivo mouse Feel free to contact me : darrancronshaw gmail.com . Open networker to people in related professional fields or avocations see ' additional info interests ' in LinkedIn profile .. Technologies :
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biologics;developing
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Associate Professor . . . Technologies :
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Head Biostatistics . NEXUS Personalized Health Technologies ETHZ , . Clinical Bioinformatics Unit : . Supervising a team of professional biostatisticians . Contributions as co PI or partner to grant applications . Management of data analysis projects . Our analysis portfolio is focused to : . anyOMICS analysis . Single cell analysis . Machine Learning , Deep Learning , AI . Clinical outcome prediction , biomarker discovery validation . Spectral , time series time to event analysis . High dimensional statistical modeling regression , classification , prediction . Data analysis for personalized and translational medicine . In my role as head of biostatistics I am leading a small team of professional biostatisticians within the technology platform NEXUS at ETH Zurich . In addition , I am a senior scientist with a biophysics and statistics background . I am passionate about squeezing out data to extract as much information as possible . My specialty is the analysis of high dimensional and complex data , single molecule or single cell data , and image analysis . Currently I am enabling personalized medicine by supporting clinical decisions using OMICS tools . In the past , In the past I was developing methods and instruments for high resolution microscopy , fluorescence spectroscopy , and high content screening . I have a 7 year industry experience in image based drug discovery and compound screening . . Technologies :
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Senior Scientist . . I am a research scientist with 10 years of experience in Cell and Molecular Biology . I am passionate about learning new things and techniques as well as employing my knowledge and skills to yield solutions to various challenges in science and technology to help people .. Technologies :
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Special Consultant . . I am a curious , open minded , and PhD in molecular structural biology . I have eight years of hands on experience in recombinant protein production techniques and structural biology , 6 years of single particle cryo TEM experience . I am used to working both independently and in teams , making project related decisions , managing collaborations , and reporting results .. Technologies : CryoEM
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proteins;expression;structure
|
Scientific Investigator , Computational Biology . . Experienced Scientist with a demonstrated history of working in the research industry . Highly skilled data analyst with strong research background and diligent attention to details , ready to incorporate and investigate complex biological and cellular data to tackle different challenges in science . Excellent understanding of biological and pharmaceuticals data analyses including genomics , multi omics and network based drug discovery .. Technologies :
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PhD Researcher at KU Leuven and Janssen Pharmaceutical Companies of Johnson Johnson . . PhD Researcher in Pharmaceutical Sciences . Currently working on the development of intrabodies to target Tau pathology in Alzheimer 's Disease . This project is a collaboration between the Laboratory for Therapeutic and Diagnostic Antibodies KU Leuven and the Neuroscience Department of Janssen Pharmaceutical Companies of Johnson Johnson Beerse , Belgium , co funded by VLAIO as a Baekeland mandate . . Technologies :
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antibodies;idps;interaction
|
Lead of Technology Development , Clinical Sciences and Interpretation . . Our mission at Jungla is to empower the precision medicine industry with quantitative genetic and genomic testing . We are inspired by patients , genomes and the innovative , cross disciplinary technology development . As such , our platform integrates advances in genomics , cell engineering , computational biophysics , and computer science to bring state of the art genome interpretation to patients . This work brings together advances in functional genomics , computational biophysics , cellular engineering , machine learning , security , and a high performance computing platform to deliver robust , comprehensive , and clear clinical guidance . We thrive on integrating diverse areas of expertise in cross disciplinary teams and innovation as new capabilities in clinical settings . If you are interested in what we are building , we d love to hear from you . I grew up in France and San Diego , and I spend my weekends cooking , running and tinkering with new technology .. Technologies :
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Senior Bioinformatics Research Engineer . . . Technologies :
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Principal Bioinformatics Scientist II , Roche Sequencing Solutions . . Extensive 20 years algorithm development experience in Computational Molecular Biology . Recent accomplishments include : A novel algorithm for prediction of genomic Copy Number Variation based on continuous signal interpolation . It is sensitive to short variations down to 100 bps and has relatively low novelty rate . The algorithm became part of Revolocity sequencing technology built by Complete Genomics and its performance was presented at ASHG 2015 . Proprietary time efficient algorithm for MS MS unrestricted database search of peptides with unanticipated modifications . The algorithm was placed 2 nd out of 17 in the annual iPRG 2013 blind study . Areas of expertise : statistical methods for DNA and protein sequence analysis , NGS , large scale genomic variation , multiple sequence alignment , Hidden Markov Models , evolutionary inference , protein clustering , and MSMS spectrometry . Programming experience : C C , Perl , Python , MATLAB , Unix . . Technologies :
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Senior Director , Computational Biology . . Solving the problems of the Bio Pharma Industry through research , analytics and hypothesis generation to extract high value information from public and proprietary data . I am a biologist with knowledge across computing , statistics and the drug discovery development process . I combine these in interesting ways to find solutions to challenging problems . Exceptionally organized individual contributor , team player or lead , able to prioritize and execute on multiple fronts on time and on target . Specialties : computational biology , bioinformatics , genomics , systems biology , pathway analysis , software development , R , Python , Perl , SQL , PL SQL , HTML CSS JavaScript , communication written and verbal , problem solving . Technologies :
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Scientist II . Hepatitis B virus HBV and its subviral agent Hepatitis D Virus HDV are a major global health problem with 350 million people chronically infected worldwide of which about 700,000 die every year with HBV HDV related complications including liver cancer . To date , there is no functional cure for chronically infected patients . At Assembly Biosciences , I work on small molecule viral entry and assembly inhibitors , as well as immune modulators , to develop a cure for chronic HBV HDV infections . . Hepatitis B virus HBV and its subviral agent Hepatitis D Virus HDV are a major global health problem . At Assembly Biosciences , I work on small molecule viral entry and assembly inhibitors , as well as immune modulators , to develop a cure for chronic HBV HDV infections . Previously , I worked as an Assistant Scientist at the Morgridge Institute for Research in the lab of Dr. Paul Ahlquist where I worked with a highly advanced Nodavirus model system to study replication complex RC assembly , structure and function via a combination of cryo electron microscopy and biochemical techniques . A detailed molecular understanding of viral RCs is essential to find novel drug targets to inhibit the replication and spread of RNA viruses such as SARS and MERS coronaviruses , Dengue , Zika and Hepatitis C viruses . As a graduate research assistant at University of Wisconsin Madison in the lab of Dr. Dan Loeb , I studied the replication of HBV by fixed and time lapse fluorescence imaging techniques to track the viral components in cells during HBV replication . Our work led to crucial insights in the trafficking of viral core and polymerase proteins in cells and also highlighted a novel role for the viral polymerase at the mitochondria which can be explored for better drug design and eradication of the virus from chronically infected patients . Before that , I worked as an Application Specialist at Hemogenomics Pvt . Ltd , where I set up and maintained NAT nucleic acid testing lab facilities for blood banks in hospitals in Mumbai .. Technologies : CryoEM
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proteins;structure
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Senior Manager . Advanced Analytical and Structural Chemistry CMC D D Small Molecule Analysis and Characterization LC MS , NMR and solid state characterization technologies . Project Management People Management Project Coordination Small Molecule Characterization Protein Analysis and Characterization Protein Stability and Biophysics Protein Formulation LC MS Hydrogen Deuterium Exchange Mass Spectrometry . Technologies : NMR
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small molecules;characterization;developing
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Biochemist . . Interested in research areas of structural biology , protein design , biochemistry , and any other inspiring fields . Technologies :
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proteins;engineering;structure
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