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Senior Scientist Principal Investigator . New main responsibility for scientific projects at Nanion in the field of membrane transporters , both in house and customer related . Principal Investigator within the NeuroTrans program funded by the European Commission s Horizon 2020 framework . . Motivated PhD level biochemist working at Nanion Technologies Munich , since 2016 . Responsible for R D using the SURFE2R technology . Research projects , product development , marketing , sales and customer support . PhD at the Max Planck Institute of Biophysics Frankfurt , 2011 2016 . Started working on membrane transporters using electrophysiology , fluorescence and radioactive transport assays . Studied biochemistry at the Goethe University Frankfurt , 2005 2011 . Well trained in biophysical techniques , protein science , molecular and cell biology . High level of project management experience Frankfurt , 2008 2012 . Raised six figure sum by writing grant proposals . Initiated and supervised scientific projects , eLearning and teaching activities . . Technologies : Xray
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PhD Molecular Biology Biochemistry . Versatile PhD with experience in both fundamental and applied research ; strong background in biochemistry molecular biology , with emphasis on enzymology and microbial biotechnology . Expertise in diverse scientific topics , including cytochrome P450 monooxygenase based biocatalysis , Nisin and Hemolysin A biogenesis , bacterial multi drug resistance , protein folding and protein secretion . . . Technologies :
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enzymes;proteins;stability
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Senior Manager . . Research and development manager with nineteen years of experience from industrial R D , spanning product and business development , project and line management , pharmaceutical formulation and device research , pre formulation , analytical development , biophysics , instrument construction and process analytical technology . I have a positive leadership style where involvement , empowerment and coaching create the foundation for motivation and a good working environment . I thrive working in explorative project phases , across cultures and borders . I motivate my team to high engagement and delivery of both short and long term goals . I am open minded , have a clear communication and find stakeholder management at all levels a central part of my work . I am detail oriented and ensure business critical goals are met in time and quality . Key competencies : Management : People leadership , project management , team organisation , cross functional and external collaborations , competency development , strategic planning , lean product development . Scientific : Materials science , device drug product research , solid and liquid pharmaceutical formulations , pre formulation , physico chemical and molecular properties , molecular spectroscopy , chemometrics , computational chemistry .. Technologies :
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formulation
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Computational Biology Data Science Director . . Dave is a senior technical leader and manager with more than 35 years of experience , emphasizing research and development as well as software medical device development in biotechnology and pharmaceutical industries and national laboratories . Currently he is the technical lead for an advanced development program at Amgen to explore medical devices built on mathematical modeling and simulation of human physiology . Previously , Dave was Amgen s Vice President of Research Development Informatics . Prior to joining Amgen , Dave was CIO and Vice President of Informatics and Information Technology at Signature Bioscience in San Francisco . Dave has also held positions with Affymetrix , Inc. , Sterling Winthrop , Inc. , Lawrence Berkeley National Lab , and Lawrence Livermore National Lab . Dave holds a Ph.D. in Applied Mathematics from the University of California Berkeley . Throughout his 35 year career , Dave has been awarded more than 15 patents in the field of database design and data visualizing techniques and has a similar number of patent applications pending . His technical interests include functional programming , formal specifications for scientific models and simulations , and the application of mathematical systems theory to biology , medicine , and drug discovery . Dave is a Fellow of the American Mathematical Society and a member of the Board of Trustees of the Institute for Pure and Applied Mathematics at the University of California Los Angeles . Dave has served as a grant proposal reviewer for the Physical Sciences Oncology branch of the NIH . . Technologies :
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Associate Researcher , CHS Research Group Noroviruses . Characterization of Nanobodies Norovirus interaction by cryo electron microscopy and X ray crystallography to provide specific diagnostic tools . Supervisor : Dr. G. Hansman . Structural biology is amazing , the graphic beauty of protein assemblies highlights the genius design of Nature . For my part , the knowledge of protein mechanism offers me the possibility to design diagnostic and therapeutic tools . That 's the attractive challenge My experience first focused on the interaction mechanisms between a bacterial lectin and several ligands in order to design anti adhesion compounds useful as an alternative to antibiotics for cystic fibrosis patients carrying bacterial infections . Since then , I keep interest in host pathogen recognition , especially those involving glycan moieties . Being familiar with synchrotron beamline data collection , phasing methods MR , SAD , MAD , MIR and structure refinement , I like taking advantages of crossed approaches like thermodynamic and inhibition tests on microplates in the Structure Based Drug Design . The exploration of viruses and immune response during my postdoctoral research HIV , Kobuvirus , Rotavirus , Norovirus , gave me skills in molecular biology and biochemistry . To understand large particle assembly icosahedral capsid microtubules , it is necessary to carry out mammalian cells culture , samples purification , cryo EM data collection , single particle reconstruction and analysis of results . Solving this puzzle is fun . Technologies : Xray;CryoEM
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antibodies;small molecules;interaction;structure
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Professor . Biochemistry , Protein structure , X ray crystallography , Protein purification , Biophysics . Research Interests : Structural biology , X ray crystallography , biophysical characterization of the signaling components of the visual signal transduction pathway , protein ligand interactions using SH3 domain containing proteins , blue light photoreceptors of the LOV family , natively unfolded proteins , protein aggregation using dynamic light scattering and CD spectroscopy . Experimental approach : The primary focus of my research is to understand the structure function relationships of soluble and membrane proteins of biological importance . My approach is to conduct these studies with techniques that allow a complete dissection of kinetic and structural properties of the proteins in static and dynamic states . The functional and thermodynamic properties on wild type and modified forms of the macromolecules generated by site directed mutagenesis are studied extensively using transient and steady state kinetics , as well as selected biophysical techniques . The functional information is then combined with the three dimensional structure determined by X ray crystallographic techniques . https : www.uni duesseldorf.de MathNat ipb index.php index 1338 detail 131 . Technologies : Xray;SLS DLS
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proteins;small molecules;characterization;expression;interaction;stability;structure
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Tenure Track Professor . Faculty member and Principal Investigator in the College of Biological Sciences , Department of Plant Biology , UC Davis . My research group aims to unravel the biological mechanisms controlling fundamental signaling pathways using diverse interdisciplinary approaches including structural biology X ray crystallography and Cryo EM , biochemistry , molecular and cell biology in plant , fungi and mammalian systems . . Dr. Nitzan Shabek is a Tenure Track Professor and a Principal Investigator at the University of California , Davis . He is also a member of the Scientific Advisory Board of OerthBio LLC an agricultural biotech company and a joint venture between Bayer and Arvinas . His research group at UC Davis integrates cutting edge approaches from the fields of structural biology , biochemistry , molecular biology , and plant biology to elucidate signal transduction pathways and revealing their regulation by the Ubiquitin Proteasome System . His laboratory also addresses pathophysiological challenges through innovative bio engineering synthetic biology strategies . He received several distinct awards including the UC Davis Award for Innovation and Creativity , the National Science Foundation NSF CAREER Award , and the 2021 Neish Award . As a faculty member at UC Davis College of Biological Sciences , Prof. Shabek has been teaching Biochemistry classes as well as developing new educational approaches via Virtual Reality .. Technologies : Xray;CryoEM
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molecular glues;proteins;structure
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Researcher PHD Student . Cryo electron microscopy at the Beckmann Lab . . Technologies : CryoEM
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structure
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Senior Principal Scientist . Structural Biology , Cryo EM , Drug Discovery . I am passioned about patient centered drug discovery and optimizations . Teamwork , good science , and strong data are the pillars of my work . I enjoy collaborating and applying new techniques towards personalized drug discovery . Mentoring and teaching has been central to my work . Skills Extensive experience in CryoEM , Membrane biology and Team leadership . Technologies : CryoEM
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membrane proteins;structure
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Associate Director , Computational Chemistry . . I m a computational chemist with a foundation of knowledge in chemistry and biology , and a passion for drug design . In close collaboration with discovery and preclinical colleagues , I lead a group that focuses on designing , investigating , prioritizing and optimizing potential therapeutics with structure based , ligand based and informatics techniques .. Technologies :
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Statistician President . Statistical and machine learning consulting . We bring together teams of focused analysts and engineers to solve your data needs . Medical Clinical trials , Design of experiments , ... Internet Multivariate A B testing , User attrition modeling , Click optimization , ... Industrial Streaming sensor data , Failure prediction , Equipment optimization , ... Analytics Classification , Neural Networks , Prediction , Survival analysis , Unsupervised methods , Visualization Design ... Languages R , Python , Java , C , SQL Big Data Spark , HBase , Cassandra , MapReduce , Scalable algorithms . Dr. Ian Fellows is a statistician and data scientist with research interests in the intersection of mathematical statistics and computer science . He has authored 24 papers and delved deeply into many sub disciplines including artificial intelligence , where in 2007 08 his Texas Hold em AI programs were ranked second in the world . In machine learning , his contributions to modeling social networks using exponential family models have found applications in disease modeling . He is also the primary author of the open source Deducer suite of packages , which provide an easy to use graphical interface to the programming language R. His work in designing Deducer s statistical visualization interfaces won the prestigious John Chambers award . Ian has held research appointments at UCLA and UCSD , as well as the position of Chief Scientist at Osprey Data , where he lead the data science team in building scalable algorithms and infrastructure for near real time analytics on sensor data . Since 2009 his analytics consulting company has had a proven track record of bringing data science teams together to solve big data problems for a diverse range of corporate clients in fields such as education , internet marketing , and statistical software development . Visit http : www.fellstat.com for more information . Technologies :
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Senior Research Scientist . Injectable Formulation Research . Professional Profile A highly motivated multidisciplinary scientist who thrives on working with people and executing complex projects . Research and project management skills gained from working in internationally renowned centres across Europe : GSK London , MRC London , CNIO Madrid , NNF CPR DK , NN DK . My strength lies in my passion for scientific curiosity and engagement with focus on people and progress . Striving towards expanding and strengthening business understanding , shaping strategic discussions , creating organisational value and personal growth . Novo Nordisk valuable insight gained from working across R D from pre projects to G1 passage . As a formulation scientist my role includes biophysical characterisation of target products ; design short long term stability studies ; compare bi functional and co formulation studies and deliver on projects ranging from peptides to antibodies . As a drug product co ordinator , lead timely handover and technology transfer to CMC . Innovation projects allowed portfolio strategy and stakeholder management followed by driving facilitating the project across R D. Executive Management Program at IE Business school Building A Start Up : From Bench to Market . Artist oil painting and co owner of Gallery Bopa . . Technologies :
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antibodies;peptides;characterization;formulation;stability
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Director , QARA Data Analytics . Lead data scientists , BI analysts and statistician to support dashboard reports , data analytics and visualization and statistical services under quality and regulatory fields . . Senior information centric expert with 10 years of advanced data strategy and analytics skills developed through both industry and academia Enriched experience of working under highly regulated environment in MedTech Pharma companies Master of Data Speaks philosophy interrogating data to generate meaningful outputs to assist decision making Certified training on leadership and management skills through world prestigious trainer Wilson Learning and Development Dimensions International . Expertise in managing multiple projects and collaboration with internal and external stakeholders by excellent communication Solid statistical knowledge and efficient computer programming Publication records of over 30 peer reviewed journal articles , along with 50 conference abstracts . Technologies :
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Postdoctoral Researcher . . I am a postdoctoral fellow at EMBL Grenoble October 2019 present . I have recently been awarded a Marie Sk odowska Curie individual fellowship to research influenza virus transcription , primarily utilising protein production from mammalian cells and cryo electron microscopy . Previously , I completed my D.Phil in clinical medicine at the University of Oxford between October 2015 December 2019 . The focus of my research was to understand the receptor binding protein structure and biology of emerging paramyxoviruses . Prior to my doctoral work , , I was awarded a 1st for my Bsc in Microbiology with Virology Industry at the University of Leeds . During my undergraduate studies I worked at Biopharm Innovation Domantis GSK , Cambridge , as an industrial placement intern between July 2013 June 2014 .. Technologies : CryoEM
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proteins;interaction;structure
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Application Scientist . . Single particle cryoEM expert with 11 years of experience building and maintaining cryoEM labs collaborating with hundreds of researchers and thousands of samples across three major universities to determine the structure of macromolecular complexes leading to 17 co authored papers from viruses to membrane proteins . In addition the hands on EM data collection and sample preparation , I provide feedback on experiments involving cryoEM and its potential possibilities and limitations in answering biological questions . I maintain an electronic database of images cross referenced by experiment . Provide images and language suitable for grants and publications . Educate through hands on and in lecture environments both EM fundamentals and specialized techniques . Skills : Sample preparation for Cryo EM , negative staining in solution , SEM , image analysis , tomography utilizing SerialEM , and 3D particle reconstructions . Equipment : Titan Krios , Talos Artica , Gatan K2 BioQuantuum , Vitrobot , JEOL 2100 200kV Cryo equipped Lab6 TEM with Ultrascan 4000 CCD for high resolution single particle data acquisition , JEOL 1400 120kV , Gatan CP3 , and a wet lab with centrifuge and ancillary sample prep equipment . . Technologies : CryoEM
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Director CMC Protein Development . . 10 years industry experience in biologics development expert for cell line development engineering advancing coagulation factors , mAbs , VHH formats and AAV vectors from lead discovery to clinics . Technologies :
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antibodies;carriers;structure
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Doctoral Student . Computational Method Development , Automatic Protein Structure Modelling , Teaching and Supervision of Students , Presenting Results at International Scientific Conferences . Computational method developer with a passion to solve problems and unravel puzzles of all kinds . After thinking a lot about elementary particles and fields during my bachelor 's degree , I changed directions . In my master 's thesis I sought to deepen my understanding of the human brain by analysing images acquired by diffusion weighted MRI . Precisely , I introduced a new measure to quantify structural connectivity between brain regions . At the moment I am doing my PhD in the field of computational Biophysics . My field of interest are now proteins , so called building blocks of life . I work with data acquired by cryo electron microscopy . My aim is , to develop software facilitating the analysis of these data , i.e. reconstructing the atomic structure of the examined proteins .. Technologies : CryoEM
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Principal Scientist . . I am a research scientist that does biological modelling and simulations . My research focuses on applying state of the art modelling techniques to study complex biological systems . . Technologies :
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Snr Postdoctoral Researcher . . Current research at University of Hull is the optimization of deep learning architectures for time series classification . Technologies :
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Senior Algorithm Scientist . I am now focusing on camera algorithms R D , including computational photography , image processing and machine learning . . Experienced engineer scientist with a demonstrated history of working in the industry and higher education . Skilled in computer vision image processing , machine learning , secure computing , and cryptography . Strong research professional with a Doctor of Philosophy Ph.D. focused in Electrical and Computer Engineering from University of Oklahoma .. Technologies :
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Scientific Associate DNA Encoded Library Screening DEL . Transfer of a novel technology called DNA encoded library screening DEL from an external biotechnology company onto a new established team and laboratory . Establishing of the whole DEL process to the Novartis environment . Continuous optimization of the selection screening method and data analyzing process . Assay development and screening of NIBR projects with the DEL technology . Key contact to provide biological and biochemical expertise and support to the library production teams . Follow up screening of selected compounds with biochemical assays . Planning of experiments , compiling of data , interpreting of results and communication presenting to . direct supervisor and project teams . Documentation in laboratory ebooks and establishing SOPs reports . 3 . 5 months internal sabbatical in chromatin profiling group CCB to learn technics like ChIP . Seq ChIP qPCR and chromosome conformation capture 4C technology . . Research Laboratory Scientist with experience in biological , biochemical and analytical laboratories . Knowledge from over 10 years in pharmaceutical industry . Proven experiences in planning , executing and analyzing independently experiments . Excellent in problem solving , outstanding organizational skills , providing high quality within given timelines and good communication skills . Extensive experience writing research reports and protocols . Active team player who fosters collaboration . Expertise includes : . DNA encoded library screening Drug target discovery and validation by biochemical and cellular assay development with high throughput screening and compound profiling Data analysis using different tools , e. g. Spotfire Enzymology Biophysics Molecular biology Epigenetics RNA interference . . Technologies :
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small molecules;screening
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Senior Computational Biologist . . I am passionate about extracting knowledge from data using the best tools I can get my hands on . The question is always the most important component of data science . Therefore I strive to adapt my skills to the most efficient ways for getting the information required , even if that involves learning whole new set of skills . That said , I am obsessed with innovation and committed to a lifelong learning . We live in a very exciting time where we have free access to unprecedented volume of high quality information so I am constantly trying improve myself as a professional and as person .. Technologies :
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Senior Scientist Mathematical Modeler . . My specialization exists at the interface between dry and wet lab approaches . I enjoy strategizing how to model complex phenomena based on the goal , the data , and the unavoidable assumptions . I 'm particularly fascinated with dynamical systems . I am a PhD level computational biologist with 8 years of academic research . I am passionate building and comparing predictive models trained on biological data . Highly knowledgeable in different forms of machine learning , python , and MAPK signaling biology . I love mentoring and collaborating When I 'm not at my computer , I go rock climbing , mountain biking , and backpacking .. Technologies :
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Scientist . Antibody production , analysis , and engineering . . Technologies :
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antibodies;characterization;engineering
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Researcher . Researcher and supervisor for electrophysiology , molecular biology , protein biochemistry , and molecular dynamics experiments to elucidate structure and function of membrane proteins relevant to human drug use and drug design . . I am a biochemist studying the molecular interactions between brain proteins and drugs that alter behavior and experience .. Technologies :
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membrane proteins;proteins;interaction;structure
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Graduate Research Assistant . Graduate research and teaching assistant in the Department of Molecular Biosciences , advised by Dr. Arlen Johnson and Dr. David Taylor . Investigating the structures of intermediates of ribosome biogenesis , using yeast genetics and cryo electron microscopy . . . Technologies : CryoEM
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proteins;structure
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Principle Computer Biologist . The HAVANA team carry out the manual analysis and annotation of vertebrate genome sequences , and generate the GENCODE geneset for the human ENCODE project . I play a key role in both the planning and implementation of our scientific strategy , and manage 7 members of staff . My recent achievements include : Developing pipelines for the integration of next generation datasets into gene annotation , including RNAseq , CAGE , ribosome profiling , mass spectrometry . Working to improve the usablity of our resources , in particular to help distinguish and understand functional transcription events . Promoting our resources at international meetings , presenting at conferences including ASHG , Genome Informatics , HGM , SMBE and AGBT . Detailing our work in several high impact publications , listed below . Coordinating our annotation with the ongoing efforts of the Genome Reference Consortium . Reaching out to other communities to show how we can aid them . In particular , I am now working with disease biologists and clinicians on the interpretation of variation linked to specific diseases . Organising and running workshops , for example a 2 day meeting focusing on protegenomics . Publications as first author : Improving GENCODE reference gene annotation using a high stringency proteogenomics workflow . Nat Commun . 2016 Creating reference gene annotation for the mouse C57BL6 J genome assembly . Mamm Genome . 2015 Functional transcriptomics in the post ENCODE era . Genome Res . 2013 The origins , evolution , and functional potential of alternative splicing in vertebrates . Mol Biol Evol . 2011 Dynamic instability of the major urinary protein gene family revealed by genomic and phenotypic comparisons between C57 and 129 strain mice . Genome Biol . 2008 Evolutionary implications of pericentromeric gene expression in humans . Cytogenet Genome Res . 2005 Neocentromeres in 15q24 26 map to duplicons which flanked an ancestral centromere in 15q25 . Genome Res . 2003 . I am a genome scientist , specifically a Principle Computer Biologist and manager at the Wellcome Trust Sanger Institute . My field of work concerns the study of the human transcriptome , and I have made significant contributions to the GENCODE and ENCODE projects . My particular interest is the function and evolution of transcriptional complexity , and I am now developing these ideas in the field of variation analysis . Specifically , I wish to understand how variation interpretation can be confounded by the existence of transcriptional complexity . I am also working on the development of proteogenomics methodologies to aid gene discovery , as well as the integration of novel datasets such as RNAseq and Hi C into annotation workflows . . Technologies :
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Co Director . . I 'm a group leader of the Analysis , Visualisation and Informatics AVI group at Oxford University working on new ways to analyse and integrate biological research and clinical data . We 're developing new ways of visualising massive multi dimensional data sets using techniques from machine learning to immersive technologies such as virtual reality . My current areas of research include spatial proteomics , multiplex imaging , epigenetics and 3D genome modelling . My key areas of interest are developing software that allow scientists to get insight from the ever increasing amounts of data being generated in biomedicine . I am especially interested in visualisation and using supervised and unsupervised deep learning techniques on large datasets combined with easy to use interfaces to augment human intelligence . This has led to me setting up an Oxford spin out software visualisation company called Zegami . My latest research interest is spatial computing and we are developing applications in Virtual and Augmented Reality in the medical space . I 've been programming computers since the early 1980s and have loved biology from an early age . I got a microscope as a Christmas present when I was 9 and used to spend hours looking at biological specimens under it . Being able to combine computers and biology as a career is a dream come true As as result I studied a Microbiology BSc and then Computer Science MSc and got my first job working at Glaxo now GlaxoSmithkline to work on the ' new ' and exciting field of bioinformatics . I learnt so much there about bioinformatics and working in industry and after a few years decided to work at a bioinformatics start up in Australia . I made the decision to come back and work in the UK for an SME managing a proteomics bioinformatics group but wanted to get hands on again . As a result I moved to academia and set up a bioinformatics core facility at Oxford University . Working at Oxford University and developing your own research ideas is an amazing opportunity and am privileged to work with world class scientists and cutting edge techniques and equipment . I manage a team who are great mix of talented researchers and students .. Technologies :
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BIOVIA Lead Scientist . . Computational chemist with many years experience of applying modelling informatics solutions in a drug discovery environment . Specialties : cheminformatics , structure based design , fragment based design . Technologies :
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Specialist , CMC and Formulation . Translating AI generated insights into tangible medicines for patients in a truly agile organisation Formulation and CMC for personalised cancer immunotherapy and novel vaccines Analytical strategy , development and qualification Formulation of proteins , nucleic acids and adjuvants Collaboration with CROs CDMOs Stability studies Batch record reviews , OOS , root cause investigations , trouble shooting and problem solving . Pharmacist and PhD in chemistry with interdisciplinary knowledge and experience within proteins , peptides , nucleic acids , nanoparticles , polymer analysis and injection devices . 10 years of industrial experience at the interface of formulation , analytics and CMC , setting and executing analytical and formulation strategies . Drawing on my broad scientific experience , I am bridging disciplines and people to create world class solutions that drive projects . Key competencies : Analytical chemistry , biophysics , nanoparticles , formulation and CMC Respectful and assertive approach to people and projects Advanced problem solving and coordination skills Efficient communicator for multiple audiences Strong cooperation and networking skills across disciplines and cultures Hands on , resilient , and agile in my approach to work , I have contributed to multiple projects and innovations in pharmaceutical research and development and mentored several technicians , MSc and PhD students . I engage and build trustful and productive relations across disciplines and cultures through quality , integrity and transparency in everything I do . I listen to learn . I start with the end in mind and strive to create win win solutions for all stakeholders . I build bridges between people and disciplines . I deliver . I innovate .. Technologies :
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biologics;nucleic acids;proteins;formulation;stability
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Postdoctoral Researcher . At the Center for Alzheimer s and Neurodegenerative Diseases , I focus on understanding and unraveling novel molecular mechanisms of protein aggregation in situ associated with neurodegenerative diseases using cryo correlative light electron microscopy cryo CLEM , cryo electron microscopy tomography cryo EM ET , and integrative modeling . . As a scientist , I am inspired to understand the biological mechanisms of neurodegenerative diseases at the cellular and molecular level for the purpose of therapeutic interventions . I have 12 years of solid research experience in industry and academia altogether . I am an independent researcher , and flexible to challenging and demanding atmosphere . Driven by curiosity , I want to dedicate my scientific career to translate the knowledge gained by basic research into potential therapy for neurodegenerative diseases .. Technologies : CryoEM
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idps;structure
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Senior Scientist . Inhalation Product Development . Expertise in biophysical chemistry , protein technology and analytical chemistry .. Technologies :
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Senior Bioinformatics Software Engineer . . Experienced Staff Scientist with a demonstrated history of working in the higher education industry . Skilled in Computer Science , Molecular Biology , Biotechnology , Java , and Biomedical Engineering . Strong research professional with a Doctor of Philosophy Ph.D. focused in Biomedical Informatics from Stanford University . . Technologies :
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Scientist . . Graduate researcher with a demonstrated history of working in the higher education industry . Skilled in Molecular Biology , Cell Culture , Data Analysis , Protein Purification , Crystallization , and Cryo Electron Microscopy . Strong work ethic and education from Arizona State University . . Technologies : CryoEM
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proteins;structure
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Medical Assessor Medicinsk utredare . . I have a long and solid research experience in Biochemistry , Biophysics and Structural Biology for studying Molecular Enzymology , Signaling and for development of potent and selective enzyme inhibitors . . Technologies :
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enzymes;characterization;structure
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Scientist II . . Protein scientist Experienced in recombinant protein design , expression e. coli , insect Baculovirus , mammalian BacMam , transient transfection , purification and characterization for : Structural studies with X ray crystallography and Cryo EM Antibody discovery campaigns hybridoma and phage display Experienced in protein expression construct design for increased protein solubility and stability . Experienced in developing functional assays for validating protein reagents . Specialized in Automated High throughput technologies for : Baculovirus production Protein expression in E. coli , insect , and mammalian cells in miniaturized formats Antibody purification Purification optimizations of intracellular , transmembrane , and extracellular proteins Work Authorizations in : USA Greencard holder Canada Canadian Citizen Japan Special Permanent Resident . Technologies : Xray;CryoEM
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antibodies;proteins;characterization;developing;expression;interaction;structure
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Senior Research Scientist . Senior Scientist , Oncology Safety Sciences , Oncology R D. . Build a platform with gastrointestinal GI organoids to investigate drug induced GI toxicity : . 1 . Assessing and predicting GI toxicity of the project compounds such as small molecule inhibitors , PROTAC and biologics such as Antibody Drug Conjugates , i. e. , ADCs with cytotoxicity assays on 3D intestinal organoids . . 2 . In vivo clinical adverse events to in vitro preclinical assays back translation assessment . 3 . Cross species translation assessment with intestinal organoids from species including mouse , rat , dog , and human . 4 . Genetic modifications with CRISPR Cas9 on GI organoids to support on off target assessment and mechanism of actions MoA studies . 5 . WB , Q PCR , flow cytometry with intestinal organoids to support MoA studies . Develop in vitro assays to study drug induced skeletal muscle toxicity : . 1 . Established rat L6 , and rat human primary skeletal muscle cell cultures myoblasts and myotubes in house . 2 . Set up cytotoxicity assays with skeletal muscle cells to predict drug induced skeletal muscle toxicity . 3 . Lauched lysate based and cell based biochemical assays to quantify activities of relevant enzymes in rat skeletal muscle cells . . Scientist with a strong background in cellular molecular biology , RNA biology , and toxicology .. Technologies :
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antibodies;molecular glues;nucleic acids;small molecules;characterization
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Sr . Data Scientist . . Data Scientist with experience in generative deep learning models like Variational Autoencoders , anomaly detection for cybersecurity , and NLP using pre trained language models and LSTMs , among other projects . I have a keen interest in leveraging digital transformation to conceive novel use cases and applying machine learning methods to provide data driven solutions and actionable insights . My past work has also involved assembling parasite genomes from short reads and building 3D models of protein molecules using X ray crystallography and cryo EM .. Technologies : Xray;CryoEM
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Research Associate . . Multi disciplinary scientist with a strong background and extensive experience in molecular biology , biochemistry , nucleic acid and protein chemistry , protein purification , enzyme kinetics , X ray crystallography and cryo EM single particle reconstitution . Vast knowledge in DNA repair , nonhomologous DNA end joining NHEJ , V D J recombination , severe combined immunodeficiency SCID , cancer , autoimmune diseases and bacterial glycogen starch synthesis . Worked independently and collaboratively with multidisciplinary teams . Assisted CROs in a NExT drug discovery project . Outstanding work ethic , detail oriented , strong leadership , communication , training and troubleshooting skills .. Technologies : Xray;CryoEM
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proteins;structure
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Formulation Scientist . . I am a recent MSc graduate in Pharmaceutical Sciences , honored with the H.C. rsted Medal for graduating with excellence , and I am very enthusiastic about working with R D and production of biological therapeutics . I have a broad pharmaceutical background that I successfully applied for CMC development of peptide injectables and research in oral delivery of biopharmaceuticals . I have had analytical formulation product responsibilities and gained core competencies within peptide characterization , method development , HPLC and biophysics . I got a valuable insight into product development , manufacturing processes and regulations , which enables me to prepare protocols , design stability studies DoE , execute experiments , review documentation , and ensure pharmacopoeia compliance in a GXP regulated environment . As a person , I am curious , quality minded and a fast learner with a strong work ethic and analytical sense . I enjoy team collaboration with the focus on the common goal , and I value contributing to a positive working environment through a helpful and friendly attitude .. Technologies :
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biologics;peptides;characterization;formulation
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PHD Fellow . . I am a biotechnologist with specialisation in cell and molecular biotechnology and graduated in MSc Pharmaceutical Sciences . I have hands on experience in both in vitro and in vivo methodologies and I am currently working with cryo electron microscopy analysing protein structure and function . Check my latest paper on the structure and function of stator units of the bacterial flagellar motor : https : www.cell.com cell fulltext S0092 8674 20 31007 2 . Technologies : CryoEM
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proteins;structure
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Research Assistant . The del M rmol lab studies the molecular mechanisms of sensory transduction , seeking to understand how animals detect the physical and chemical cues from their environment and transform them into cellular signals . In particular , we focus on the sense of smell in insect vectors of disease . In the del M rmol lab , we use cryo electron microscopy and a variety of biochemical , electrophysiological , and functional assays to dissect the structure and function of insect olfactory receptors involved in the detection of complex odors . . I received my Biology degree at the University of Texas with High Honors . I am now working at Harvard Medical School as a research assistant , studying the molecular aspects of olfactory reception in mosquitos . My long term goals include graduate medical education in order to determine how my love for molecular biology can compliment my interest in procedural medicine , orthopaedics , and orthobiologics . . Technologies : CryoEM
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proteins;structure
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Director , Head of Therapeutic Oncology Research bei Nuvisan group . . Specialities : Drug Discovery , Project Managment , Preclinical Pharmacology , Target Validation , Chemical Biology , Lead Optimization , Epigenetics . Technologies : ITC;SPR
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nucleic acids;proteins;small molecules;screening
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Head of Research Division of Computational Biology . The Division of Computational Biology brings together scientists with skills in developing and applying computational , mathematical and biophysical techniques to questions in biological and medical research . Members of the division either have their own wet lab or collaborate closely with wet lab experimentalists or clinicians to extract maximum value from experimental data that informs the development of predictive algorithms and models that may be tested experimentally . The Division shares a vision of Computational Biology as the focal point for the convergence of computing , mathematics and the physical sciences with experimental biology . The Division occupies one floor of the Discovery Centre building which is physically linked to the rest of the School of Life Sciences research complex MSI , WT and JBC buildings . We are actively seeking to make new group leader appointments in the Division . Address informal enquiries to Geoff Barton . For more information on current members of Computational Biology see : http : www.lifesci.dundee.ac.uk research cb . . Technologies :
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Associate Professor . Organizer of International Scientific Meetings : Coorganizer of IUPHAR Teaching Section in Copenhagen , Denmark : Pre Conference Satellite Meeting to WorldPharma2010 , Faculty of Pharmaceutical Sciences , University of Copenhagen , 17 . 18 . juli 2010 . Departmental responsibilities were related to coordination of teaching activities , proper scheduling of different departmental courses during the semester , providing advise on the content of courses as well as on creating new courses when necessary , and finally evaluation of the courses in order to ensure that the department is capable of providing the students with good quality , attractive and coherent teaching : Chairman of the Teaching Committee at the Dept . of Pharmacology and Pharmacotherapy , Faculty of Pharmaceutical Sciences , University of Copenhagen : from January 2008 August 2012 . Member of Didactic Committee at the Faculty of Pharmaceutical Sciences , University of Copenhagen : from January 2008 March 2012 . Member of the Committee for Research and Innovation at the Dept . of Drug Design and Pharmacology , University of Copenhagen : August 2012 May 2019 . Invited lecture Scandinavia : 1 The Scandinavian Physiological Society Annual Meeting , August 14 16 , 2009 , Uppsala , Sweden . The title of talk : calcitonin gene related peptide CGRP receptors and signaling pathway in vasculature . 2 Annual DARC Symposium Danish Arrhythmia Research Centre , 02 . November 2006 , Henrik Dam Auditorium , The Panum Institute , Organizer : prof . S ren Peter Olesen . The title of talk : vascular tone in health and disease 3 Biologue Matchmaking meeting within the field of cardiovascular diseases held at NeuroSearch A S and chaired by Prof. S ren Peter Olesen , 25 . November 2005 . The title of talk : Calcitonin gene related peptide CGRP : Cardiovascular effects and potential therapeutic applications . . Throughout my academic career , I have been focusing on the regulation of vascular tone in health and disease diabetes type I II , stroke , hypertension , congestive heart failure , migraine , and age related changes . Coronary arteries are densely innervated by sensory nerve endings containing calcitonin gene related peptide CGRP . CGRP is a potent naturally occurring 37 amino acid vasodilatory neuropeptide that is released from the perivascular sensory nerve endings in the wall of flow regulating intramural coronary arteries during hypoxia and by low pH levels in the myocardium , thus suggesting a vasodilatory role under ischemic conditions . So far , our studies demonstrate a larger CGRP receptor density in resistance arteries internal lumen diameter 200 m compared to larger conductance arteries internal lumen diameter 200 m , indicating that receptor distribution , calcium handling , ion channels , and second messengers may be finely adjusted within the circulatory system , probably reflecting the physiological demands on the vascular segments . CGRP receptor consists of three components , calcitonin receptor like receptor CLR , a specific chaperone called receptor activity modifying protein 1 RAMP1 , and receptor component protein RCP . A novel family of chaperone proteins , called RAMPs RAMP1 , RAMP2 , and RAMP3 were identified as proteins escorting CLR to the plasma membrane to generate either CGRP when associated with RAMP1 or adrenomedullin receptors when associated with RAMP2 or RAMP3 . CLR belongs to class B of the G protein coupled receptor GPCR family and is linked to Gs protein . Our studies will shed light on the complexity of CGRP receptor pharmacology as well as its complex signaling pathway , thereby helping us understand its physiology as well as its role under different circulatory complications such as stroke , ischemia , hypertension , and migraine . Techniques and specialties : Myography wire and pressurized , Electric field stimulation , Langendorff perfused heart preparation , fluorescence microscopy , stereology , measurement of intracellular calcium concentration , Investigations of G protein coupled receptor signaling pathways , and other classical molecular biology methods .. Technologies :
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Head Of Department . Leading early research activities in oral macromolecule delivery . Driving research strategy and prioritization . Exploring new avenues of treatment in diabetes , CVD , haemophilia and other life threatening diseases . . Passionate people manager and scientist . Currently heading Oral Drug Product Research at Novo Nordisk . Competencies : Leadership and management Preclinical research strategy Project management Outsourcing and academic collaborations Scientific skillsets : Protein biophysics and interaction Oral and injectable formulation of biologics Drug discovery HTS Small molecules , peptides , proteins and oligonucleotides as drug modalities . Technologies :
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carriers;nucleic acids;peptides;proteins;small molecules;characterization;interaction;screening
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Senior Director , Computational Biology NGS Bioinformatics . R D Analytics , HPC Algorithms Software Hardware , AI , Cloud Local Software Engineering , Data and Network Management , Web UI . . Currently in charge of R D Analytics , HPC Algorithms Software Hardware , AI , Cloud Local Software Engineering , Data and Network Management , Web UI . Developer of core algorithms for application specific base calling , alignment , assembly , error correction , and SNV CNV Fusion Expression calling . Coded and integrated those methods into customer facing software on the local server and cloud infrastructures . Delivered multiple internal R D software tools used to improve sequencing chemistry , enzymes , library construction , templating , and signal collection hardware . R D Leader for Liquid Biopsy cfDNA and cfRNA analysis applications . Working with multidisciplinary teams of Molecular Biologists , Chemists , Hardware and Software engineers , and Clinical Genomics Oncologists Pathologists collaborators . Designed the whole solution , performed analysis and created software tools to enable novel library preparation , instrument , and sequencing technologies in order to develop an efficient algorithm to deliver best in class solution for detecting SNV CNV Fusion variants under 0.1 limit of detection . Manager of R D algorithm development team responsible for developing applications in the area of Oncology , Liquid Biopsies , Immuno Oncology , Immune Repertoire , Infectious Diseases , and Pharmaco Genomics . Have strong algorithm design , programming , mathematical modeling , and analytical skills . Spent lots of time analyzing patient samples or population derived NGS data from internal and external collaborators , and data with purposely constructed experimental designs to answer challenging biological and technology questions . Have good insights for explaining technology artifacts vs real biology based on sequencing data . Well familiar with PCP product development cycle , and with Agile software development life cycles . Author of 11 US Patents in computational methods and NGS application techniques . Published numerous high profile papers and recently presented at multiple top conferences in Oncology , Pathology , and Computational Biology Methods .. Technologies :
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Instructor in Medicine , Division of Sleep and Circadian Disorders . Ongoing next generation sequencing analysis of healthy and disordered sleep and related comorbidities in the NHLBI TOPMed Consortium . Large scale electronic health record EHR analyses of sleep apnea and its relationship to COVID 19 and other disorders . . Specializing in human sleep , circadian rhythms and related comorbidities research using genetic epidemiology , GWAS , whole genome sequencing , and bioinformatics . 77 . Multi ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation . Nat Genet 2022 accepted . 76 . Assessing the Contribution of Rare Genetic Variants to Phenotypes of Chronic Obstructive Pulmonary Disease Using Whole Genome Sequence Data . Human Mol Genet 2022 accepted . 75 . Polygenic Transcriptome Risk Scores for COPD and Lung Function Improve Cross ethnic Portability of Prediction in the NHLBI TOPMed Program . AJHG 2022 accepted . 74 . Rare coding variants in RCN3 are associated with blood pressure . BMC Genomics 2022 Feb 19;23 1 : 148 . 73 . Pathway specific Polygenic Risk Scores PRS identify OSA related pathways differentially moderating genetic susceptibility to CAD . Circ Genom Precis Med 2022 accepted . 72 . Upregulated heme biosynthesis increases obstructive sleep apnea severity : a pathway based mendelian randomization study . Scientific Reports Sci Rep. 2022;12 1 : 1472 . 71 . Sleep Apnea Phenotyping and Relationship to Disease in a Large Clinical Biobank . JAMIA Open 2022;5 1 : ooab117 . 70 . Genetic determinants of telomere length from 109,122 ancestrally diverse whole genome sequences in TOPMed . Cell Genomics 2022 2:100084 . 68 . Rare coding variants in 35 genes associate with circulating lipid levels a multi ancestry analysis of 170,000 exomes . AJHG 2022 ; 109 1 : 81 96 . 67 . Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank . BMC Medicine 2022;20 1 : 5 . 66 . The power of genetic diversity in genome wide association studies of lipids . Nature . 2021 Dec 9 online ahead of print . 62 . Whole Genome Association Analyses of Sleep disordered Breathing Phenotypes in the NHLBI TOPMed Program . Genome Medicine 2021 Aug 26;13 1 : 136 . 54 . Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program . Nature 2021 ; 590 7845 : 290 299 . 51 . Sleep Apnea and Covid 19 Mortality and Hospitalization . AJRCCM 2020 ; 202 10 : 1462 1464 . Preprints 87 . MedRxiv 2022.02.16.22271055 . 86 . BioRxiv 2022.01.07.475305 . 85 . MedRxiv 2021.12.15.21267852 . 84 . BioRxiv 2021.12.10.471810 . 83 . BioRxiv 2021.12.07.470215 . 82 . BioRxiv 2021.11.05.467531 . 81 . BioRxiv 2021.10.11.463514 . 80 . BioRxiv 749010 . 79 . MedRxiv 2020.12.31.20234310 . 78 . MedRxiv 2020.11.13.20221812 . Full bibliography available at : https : orcid.org 0000 0003 1424 0673 . Technologies :
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Senior Associate Scientist . API Commercial Scale Up supporting project management from Process Validation Characterisation , data interpretation , Lab Investigations , Protocol Report Authoring for BLA filing . Co ordination of Scale up analytical testing with multiple third party depts . , Event Deviation support troubleshooting to meet business needs . Co ordination of New Oncology Product Stability Management , Bioassay Analytical Method transfers , Verifications and Co Validations , Equipment procurement and qualification for expanding NPI portfolio . Implement Transfer Guidelines to support introduction of new technologies for global Bioassay team . Co ordination of Clinical and Release Sample testing of In Process , FVP , FLP , FB , PFS and Stability Bioanalytical testing within product testing group . Implement and author Training modules to support Analyst Training , Technical coaching training of area personnel on specific cell based bioassays and Process Impurity tests qPCR , Elisa and HCP . Perform Data and Method Technical Investigations DOE , review and approval Including Deviations , CAPA s and Change Controls . Technical liaison with Bioassay Method Development Group , external vendors and 3rd level institutions relevant government bodies As SME primary point of contact . Yellow Belt accreditation ; use of problem solving tools to determine root cause of events A3 , fishbone , 5 Why s . Participate in Process Improvement initiatives through Lean labs and encourage use of Kaizen tools , 6S within CRS team . Participate in risk assessments , inspections , audits , etc . and implement and follow up Change Controls and CAPA s assigned . Audit External Contract Facilities to support Outsourcing Initiatives . Cork CRS Bioassay representative for qPCR , HCP , Cell based Bioassay Methods and new Non Platform Method introduction to Cork CRS . . . Profile : Senior Associate Scientist who as a member of the PDMS dept . , Janssen Sciences Ireland JSI is committed to Process Validation Characterisation for commercial Scale Up of Large Molecule monoclonal antibody production . Previously as a member of the Clinical Release Stability dept in JSI , I was committed to Bioassay transfers co validations , cell culture , troubleshooting within the USP guidelines in a GLP , GMP , ISO regulated quality pharmaceutical environment . I have over 10 years experience in Microbiology , Medical Device Diagnostics , Clinical Research and Biopharmaceutical Manufacturing Facilities . Throughout this time , I have gained great experience across a variety of Project Management , Technical and Leadership roles within R D and Quality . I have a proven ability to work as a dedicated team member within my department and with various business units , but am also very capable of working independently . I have built up a solid reputation at a local level for being reliable and capable of making important interpersonal and analytical decisions . My scientific background allows me to be technically minded , while my quality based experience allows me to deal with issues in a compliant and effective manner . I have strong verbal and written communication skills and excellent interpersonal skills . . Technologies :
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antibodies;quality
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Associate Professor . . Medical Biotechnology research with focus on organoids and advanced imaging techniques . Always looking for interesting new projects and collaborations . Specialties : Membrane protein expression and crystallisation . Biochemistry . Crystallographic data collection and analysis . cryoET and in vivo structural biology . Organoids . X ray imaging techniques .. Technologies : Xray
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membrane proteins;expression;structure
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Director Scientific Products , Scientific Product Line Manager . Responsible for team of product managers and portfolio of 100 products and tools for 600 Data and Computational Scientists at NIBR ; liaison for large scale compute and storage infrastructure needs spanning on prem and cloud options . . IT leader experienced in building cross functional teams delivering impactful informatics solutions .. Technologies :
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Postdoctoral Researcher . 1 Proteomic analysis of transmembrane proteins GPCRs , Calcium ATPases 2 Large scale purification of transmembrane protein complexes for Cryo EM . . Technologies : CryoEM
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membrane proteins;structure
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Senior Scientist . . I am motivated in understanding nature and people . I find great fulfillment when helping others to perform at their best and advocate for respect to diversity , trust , and collaboration . I have a deep scientific interest in understanding the fundamental principles that govern protein function and regulation with a focus on the cellular networks that are connected to cell death . I have a Ph.D. in Biology with experience in biochemistry , biophysics , molecular and cell biology , and quantitative light microscopy . I currently apply these methods to disclose essential steps for the regulation and execution of cell death as new potential targets in the clinics . I have strong experience in leading and working in interdisciplinary and multicultural teams , in addition to project management and training and supervision of students . I am enthusiastic about learning while solving concrete problems and open to new challenges . I like to set ambitious goals and reach them while working in teams .. Technologies :
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proteins;small molecules;interaction
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Senior Scientist In Vivo Pharmacology . . Currently I 'm working as a Senior Scientist In Vivo Pharmacology at eTheRNA immunotherapies , a biotech company focused on developing first in class mRNA immunotherapies for the treatment of cancer and infectious diseases . Within the translational team I 'm responsible in setting up the preclinical strategy of several projects and outlining and reporting of PD , PK , immunogenicity and GLP safety toxicity studies . Thereby also contributing to preparation of regulatory documents . In addition , for one of the oncology projects I 'm assigned as project leader . My career in the biotech industry started after obtaining a double PhD in Pharmacy at the Vrije Universiteit Brussel and in Veterinary Sciences at the University of S o Paulo . I first started as an Associate Scientist in the Exploratory Pharmacology team at Ablynx , who develops single domain antibody fragments Nanobodies in several disease areas . Afterwards , I got the opportunity to work as a Senior R D Manager at Promethera Biosciences , developing cell based therapies for treatment of liver diseases . Recently , in November 2021 , I obtained a certification as Diplomate of the American Board of Toxicology DABT . . Technologies :
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nucleic acids
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Associate Director , Immunology Program . . Associate Director of the Immunology program directed by Dr. Ramnik Xavier at the Broad Institute Former scientific Editor at Cell , with a focus on immunology , cancer , biophysics and computational biology PhD in immunology in the field of cancer immunology , and NK and T cell response , with 4 years post doctotral experience studying inflammation and neutrophil functions Proficient with flow cytometry , microscopy and intravital imaging , common biochemistry techniques Experience with bioinformatics RNAseq , image analysis and programming R , Python , Android for both research and business analytics Complete publication list : https : scholar.google.com citations user lFM9OHsAAAAJ hl en . Technologies :
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Professor of Computer Science Bioinformatics . . I am broadly interested in bioinformatics and data science education and research , with much of my research involving undergraduate students . I regularly teach classes involving coding in Java , Python , and R ; computational and analytical methods in bioinformatics and data science ; and how to conduct and communicate research . Recent research projects have involved the development of a web application for analyzing genomic data ; a tool for quickly summarizing and searching cancer genomic literature ; and a COVID 19 dashboard for CT and its counties . Other recent work has involved the development and analysis of epidemiological simulations of COVID 19 , and the sentiment and network analyses of Twitter data . For more information about my teaching and research , please visit https : gdancik.github.io bioinformatics . Former students and others , please let me know if there are any job openings or internship opportunities at your company . . Technologies :
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Scientist . . Our rapidly changing world has created new and emerging challenges to human health and environment . These problems do n't have simple solutions and require us to re think how we interact with complex , living systems . Using science , math , and computers we can build and test living systems in our imagination . These thought experiments can help us understand how cells work like economies , how tumors will respond to treatment , or how ecosystems are affected by environmental perturbations . As a scientist , I want to create insight into how these systems work . As an engineer , I want to design new strategies for therapeutic treatments , bioprocess optimization , and maximizing ecosystem productivity . I 've spent years acquiring a highly interdisciplinary education . I 've worked in clinical , translational , and basic biomedical research . I 've cross trained both as a bench scientist and as a computer modeler . In the lab , I 've done everything from animal surgeries to molecular biology . While working on my PhD , I helped biotech companies create quantitiative models of their therapeutic and manufacturing platforms . There are n't many scientists who demonstrate this kind of versatility . I am a committed science educator . Science is a gateway for teaching empathy , understanding , and a moral foundation based on reason . To solve challenges of the 21st century , we need deep , critical , scientific thinkers in every corner of society . . Technologies :
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Project Leader . . In constant search for better pursuits in career and in life I am a detail oriented scientist with over 7 years of experience in Drug target integral membrane proteins inner and outer , at several leading academic institutions in India , Germany and Switzerland . I am skilled in various biophysical and biochemical techniques required for structural biology , biochemistry and biophysics , writing and evaluating scientific reports publications . Capable of working as a team member as well as independently . Fluent in English , Hindi , Punjabi and can converse in German B2 C1 .. Technologies :
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membrane proteins;characterization;structure
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Associate Principal Scientist . Develop iPS , stem cells primary cells based phenotypic assays and run phenotypic screens Discipline lead for phenotypic assay technology and Flow Cytometry to define bottlenecks of phenotypic assays , identify implement cutting edge technologies and explore new technologies for setting up physiologically relevant in vitro models Study 3D culture cardiac models Design and propose target based and phenotype based screening strategies cascades with biological relevant assays and screening risk assessment Long term experience and deep knowledge on ion channel and receptors pharmacology and screening Worked as Campaign Leader for several ion channel target projects Several years experiences of running HTS screening of diverse targets including GPCRs , ion channels , Kinases , and peptidases Deep datahandling experiences knowledge of both large and small scale screening results . A researcher with significant experiences within the disciplines of assay design , cellular assay development , high throughput flow cytometry , screening of phenotype based and target based drug discovery projects .. Technologies :
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membrane proteins;proteins;small molecules;interaction;screening
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Assistant Associate Professor . . Joanna Rorbach is a Group Leader at Karolinska Institute , Stockholm , with extended experience in molecular biology , genetics and biotechnology . Joanna work is focused on discovering the links between mitochondrial dysfunction and human disease . Her studies employ primary human samples , genetic , proteomic and cryo EM methods to reveal novel mechanisms and protein factors involved in mitochondrial function . Over the past years , she has co authored multiple publications , attracted highly competitive funding and received prestigious fellowships . Joanna holds a Ph.D. from University of Newcastle and conducted post doctoral training at the MRC MBU in Cambridge .. Technologies : CryoEM
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proteins;structure
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Director , NGS Bioinformatics . . . Technologies :
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Vector Synthesis Research Associate II . . . Technologies :
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Scientist I Biochemistry and Protein Engineering . . I am a highly motivated scientist with a PhD in Biochemistry and Molecular Biology . I currently have 1 first author publication in the journal Nature , and 8 co author publications . I have ten years of experience in the field of protein biochemistry , and my expertise is in enzymology and structural biology . I am interested in leveraging my diverse skill set and deep understanding of the scientific method for solving difficult problems .. Technologies :
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enzymes;proteins;structure
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Senior Scientist in Protein Production and Biochemistry Consultant from Qrios . . Hi I am an enthusiastic and curious scientist with eleven years of experience in the field of protein science , molecular biology , biochemistry , and biotechnology . I obtained my PhD degree from Complutense University in Madrid working in the field of Industrial Biotechnology where I focused on the characterization of enzymes for their application in the industry for bioremediation and paper pulp bleaching . Later on , I have worked at Chalmers University on the protein engineering of enzymes for the sustainable production of bio based adipic acid . During my years working as a researcher , I have acquired a strong background on structure function studies , recombinant expression , purification and characterization of proteins , biochemical assay development , enzymology , molecular biology , genetic engineering techniques , microbiology and analytical chemistry . I have experience in project management , including project design , planning , execution and troubleshooting . I like to look for creative solutions to challenging research problems . I am used to analyse complex data and communicate scientific results in an efficiency way . Also , I am a team player and like to collaborate with others to accomplish a common goal . My colleagues use to describe me as an easy going and reliable person , that helps to create a productive work environment . I would like to work in a position where I can apply my knowledge and expertise to obtain high quality results useful for the society . Learning about new techniques and topics related with Life Science is also a very important goal for me . Thank you for visiting my profile Do not hesitate to contact me at versa1985 gmail.com . Technologies :
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enzymes;proteins;characterization;expression
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Research Assistant . Cryo EM . Marina is an aspiring plant biologist and will begin her PhD in Plant Biology at UC Riverside starting Fall 2022 . She earned her BSc in Cellular and Molecular Biology from the University of La Verne and graduated from the Honors Program . She conducted her senior thesis research in the lab of Stacey Darling Novak where she studied first leaf formation in S. plicata identifying novel auxin mediated genes . Marina spent four years in industry at Lumos Diagnostics , Cibus and the San Diego County Public Health Lab before joining the Grotjahn and Williamson labs . The labs began their collaboration in 2019 and Marina is currently using cryo electron microscopy to visualize ribosomal intermediates in E.coli . Outside of research , Marina loves to spend time with her cats , make pies , camp , compost , and grow odd vegetables .. Technologies : CryoEM
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proteins;structure
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Associate Director Group Leader for Translational Statistics . . Saran is a University of Pennsylvania and Harvard trained Ph.D. scientist with interdisciplinary training in biostatistics , bioinformatics and computer science and combined 10 years of education , research and working experience in academic , healthcare and pharmaceuticals sectors . His experience covers clinical trials design analysis , high dimensional statistical analysis , data mining and predictive modeling in pharmaceutical , healthcare and life science fields . . Technologies :
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Bioinformatics Scientist . Working as a bioinformatics scientist under the core bioinformatics team at Guardant health , maintaining and developing bioinformatics pipelines and managing clinical relations . . Senior year Bioinformatics PhD candidate at Indiana University , working in a human microbiome lab under the direct supervision of Professor Yuzhen Ye : https : homes.luddy.indiana.edu yye lab index.php Passionate in general health and well being with a particular interest in understanding and improving human health , via integrating information from various levels . General interests include human microbiome especially the gut , understanding , assessing and predicting pathogenic and benign variants at the genome level via data mining and machine learning . General interest in applied machine learning and computational comparative genomics .. Technologies :
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Research Scientist High Throughput Biology and Screening . . Internationally experienced Scientist with a demonstrated history of working in the fields of virology , high throughput screening , PROTACs and drug discovery . https : orcid.org 0000 0002 9660 8058 . Technologies :
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molecular glues;small molecules;developing;screening
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President of the Organization for Computational Neurosciences . . . Technologies :
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Scientist , Structural Biology . Support gene to structure pipeline across multiple projects and project teams Communicate scientific results and prepare reports for internal and external purposes including regulatory submissions Participate and lead project based and technical team meetings to identify and solve problems , guide work towards project goals , communicate on going work and progress , and plan forward thinking strategies Proactively investigate new or different technologies , methods , and service providers to ensure our work is being done in a scientifically sound , efficient , and reasonable way . I am a highly motivated and team oriented biochemical scientist with skills in protein purification and X ray crystallography . During my graduate study and post doctoral study , I have solved over 20 macromolecular structures through X ray crystallography using proteins or ribosomes I ve purified . As a post doctoral fellow , I gained experience in the areas of teaching , training , and management . I have mentored both undergraduate and graduate students , laboratory technicians and other Ph . D postdoctoral fellows . I was also responsible for purchasing and configuring computational resources along with establishing a user reservation system for the university s new cryo EM core facility . I have utilized my technical expertise to perform tasks safely and stay on schedule .. Technologies : Xray;CryoEM
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proteins;structure
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Principal Scientist , Translational Research . I am a Principal Scientist in the translational research division at Tempus Labs . . I am a Principal Scientist in the Translational Research division at Tempus Labs . My role is interdisciplinary , working at the intersection of data science , software engineering , cancer biology , and genomics . I am passionate about open source software , data science , and the R programming language . I build tools , software , and infrastructure to enable data science for genomics . I have been a core team member of two successful open source bioinformatics projects . I was at the Bioconductor Project https : bioconductor.org at Dana Farber Harvard Medical School and Roswell Park . My focus was on making R Bioconductor based genomic data science scalable on the cloud . I was also a core team member for the Galaxy Project https : galaxyproject.org at Johns Hopkins . Bioconductor and the Galaxy project are computational milestones in Bioinformatics , as listed in this Nature Review paper https : www.nature.com articles nature24286 bx2 . I 'm always looking to hear from interesting people . Feel free to contact me if you 'd like to connect .. Technologies :
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PhD Fellow . Determining the structure of a bacteriophages using high resolution cryo EM and advanced molecular biology techniques . Project funded by the Leo Foundation Open Competition Grant 2019 . I am currently pursuing research in the field of structural biology analyzing bacteriophages using cryo EM and using other molecular biology techniques . Professional Competencies Bacteriophages propagation , purification and analysis CRISPR Cas based genome editing Cryo EM sample preparation , image processing and data analysis Proficient with RELION , CryoSPARC , cisTEM , Coot , Chimera and other EM data analysis tools Scientific communication and networking Bioinformatics basic I enjoy reading about different topics , ranging from science to pop culture . Productive networking over a cup of chai coffee is always welcome . Highly interested in innovation and entrepreneurship in life sciences .. Technologies : CryoEM
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proteins;structure
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Computational Chemist . . I work in the fields of biophysics and computational biology . My research focuses on studying lipid interactions with membrane proteins and developing algorithms for characterising binding activities . In addition , I also have a strong background in python programming and mathematical modelling . I have developed a python package for calculating binding kinetics and used Markov State Modelling to study GPCR oligomerisation . Through my PhD training , I have also participated in projects of computer aided drug design and fragment based drug design . . Technologies :
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Chemical Biology Therapeutics Associate Director , Data Science . . I am an experimental biologist turned bioinformatician turned data scientist , having first shifted from the bench during a decade of infectious diseases research that spanned my graduate career and my first seven years in industry . In 2018 , I changed course to leverage data science and chemical biology approaches across a broad portfolio of drug discovery projects within the Novartis Institutes for BioMedical Research . While my research on infectious diseases has waned greatly in recent years , I continue to help in the search for parasite anti infectives in collaboration with the co located Novartis Institute for Tropical Diseases . I am most interested in tool development , machine learning , and their application to problems in drug discovery research , particularly for induced proximity modalities . As the lead for the local CBT Data Science team , a small group of data scientists , I most enjoy collaborating with and enabling experimental colleagues , from helping with experimental design to visualizing and interpreting results . I 'm a father of four , an avid live music and sports fan , and an amateur musician . I serve as Director of Technology on the board of the Mockingbird Foundation , a nonprofit that raises and disburses funds to children 's music programs across the United States .. Technologies :
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Team Leader Particle Science . . . Technologies :
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Research Manager . . . Technologies :
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Engineering Manager . Engineering manager for the two teams working on Auth , Profile , Trust and Communication . . I 've always found my main motivation in understanding problems and finding good solutions to them . In my previous career I tried to find new solutions for studies of membrane proteins . I then spent a couple of year writing code to improve the experience in the Blocket android app . Nowadays I mostly focus on understanding the technical aspects of our business needs in my domains , figuring out architectural problems and on helping for my team although I still do the occasional PR in Python , React , Android , ... . The kind of problems I 've worked on have changed over the years , but the driving motivation to understand the problem and solve it has stayed the same . Technologies :
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. . I got my Bachelor in chemistry from Baghdad University . In 2011 I started to study analytical chemistry at Lund University . To get experience in biochemical and related methods . I started in 2012 studying the program in Molecular Protein Science 2012 2014 at the department of Biochemistry and Structural Biology , Lund University My Master s degree work , which is planned to be finished in May 2014 , is in molecular biophysics . My work in the Master s program was divided into three parts : 1 . Protein expressed and purification . 2 . In vitro the enzyme was tested with different inhibitors and the IC 50 was predicted for every inhibitor . 3 . Protein crystallization must possess some specific properties for the formation and growths of the crystal therefore we used different methods such as Differential Scanning Fluorimetry DSF and Dynamic Light Scattering DLS to optimize those conditions . I used different conditions to optimize the protein crystals with various inhibitors I am very interested in my project structural biology , because I passed three advanced courses . The courses are : Structural Bioinformatics , Medicinal chemistry inhibitor design , inhibitor synthase and inhibitor scanning in vitro and inhibitor analysis in pharmacokinetics and Biochemistry advance energetic metabolism , protein structure and function and purification of a membrane protein .. Technologies : SLS DLS;DSF
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membrane proteins;interaction;structure
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Staff Scientist Microscopist . . Specialties : Light Microscopy , Multi photon live cell confocal imaging Electron Microscopy TEM SEM Cryo Electron Microscopy . Technologies : CryoEM
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structure
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Bioinformatics Scientist . . . Technologies :
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PHD Graduate Student . Buchmann Institute for Molecular Life Sciences BMLS ; Prof. Frangakis group Cryo Electron Microscopy Tomography Antibiotic resistance of gram negative bacteria Structural Biology of membrane proteins in situ and in vitro . PhD student in Biochemistry and Cryo Electron Microscopy . . Technologies : CryoEM
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membrane proteins;structure
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Cryo EM Facility Manager . . . Technologies : CryoEM
| null |
PHD Student . PHD research on protein aggregation and neurodegeneration as part of the Graduate School of Quantitative Biosciences Munich QBM program . . My research career started with biotechnology , treaded through nanoscience , and concluded with a Ph.D. in Biochemistry that is currently awaiting defense . During my PhD I have learned important technical knowledge of yeast biochemistry and cryo electron microscopy , where my previous knowledge of genetic manipulation and microbiology proved invaluable . Not less important were teamwork and leadership skills which were essential when training newcomers to our department . At this point in my career , I have decided to make the jump from an academic research career to one either in industry or in public institutions . I aim to use my technical knowledge and human skills to pursue a career in management and hold positions of increasing responsibility .. Technologies : CryoEM
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idps;structure
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Electron Microscopy Specialist . Microscopy : FEI Morgagni , Tecnai G2 20 , Glacios Cryo TEM , Hitachi TM 1000 , Tescan S8000 G Cryo FIB SEM Preparation techniques : conventional chemical fixation for transmission electron microscopy , sample preparation for scanning electron microscopy , critical point drying , high pressure freezing , freeze substitution , negative staining , plunge freezing immersion freezing for cryo EM , ultramicrotomy , sputtering of different metals , carbon grid production . Small things can make a big difference . Technologies : CryoEM
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structure
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Director of iNANO . . Research : My research interests concern nuclear magnetic resonance NMR and magnetic resonance imaging MRI with specific focus on membrane proteins and fibrillating proteins and related diseases . Organization education : Director of Engineering Studies at Aarhus School of Engineering ASE . I am responsible for a newly started education in chemical engineering . Specialties : NMR , MRI . Technologies : NMR
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idps;membrane proteins;structure
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Stability Scientist . . My competences include recombinant production , purification and characterization of fungal and plant enzymes and some of the most challenging and biomedically most interesting proteins ; ion channels of human and parasite origin . During my Ph.D. at the University of Copenhagen I was the first to purify the full length human hERG K channel , an ion channel of utmost importance to heart physiology and for drug screening , and the only two K channels encoded by the malaria parasite , plasmodium falciparum , it their active form . I developed expression , purification and fermentation protocols for production in S. cerevisiae and managed to purify material enough for electrophysiological characterization and structure determination . Based on my experience with these very challenging proteins I have obtained in depth experience with pilot plant scale yeast fermentation , expression optimization , detergents , protein purification using the kta explorer , ion channel characterization and DNA technology . Key words : Recombinant protein technology , Membrane protein expression , characterization and purification , Parasitology , Molecular techniques , Malaria , hERG , Ion channels , Electro physiology Biochemistry , Cell biology , Medical research , Vaccine technology , Cell culturing , Fermentation . Cloning , Sequencing , siRNA assays , FELASA accreditation , PCR , FACS , ELISA . . Technologies :
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membrane proteins;characterization;expression;structure
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Head of Operations Senior Scientist CryoEM Core Facility , Center for Structural Systems Biology . . Biochemist with a strong structural biology background . Completed multiple projects in the areas of cryoEM , XFEL science and NMR . Focused on structure function relationship studies of helical assemblies , membrane proteins and protein complexes . Currently heading the cryoEM facility at CSSB with 2 Titan Krios , 1 Arctica , 1 Aquilos FIB SEM and an Talos L120 . With a team of EM specialists , supporting PhDs and postdoctoral researchers in visualizing infectious processes at high spatial resolution , and ultimately inside the cell exploiting single particle analysis and electron cryo tomography . Further engaged in research and development projects on campus that push the limits of CryoEM , the portfolio of facility , and growth of every team member . Projects include : integrative cryoEM XFEL SAXS approaches , tr cryo EM sample preparation , and cryo CLEM .. Technologies : CryoEM;NMR
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membrane proteins;proteins;structure
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Associate Director , Data Science . Exploratory biomarkers in clinical development . Extensive experience in leading Translational Bioinformatics and Clinical Biomarkers efforts in Clinical Development . Specialties : Clinical Cancer Genomics Bioinformatics Clinical Biomarkers Assay Vendor selection , DTS , Clinical trial documents , sample logistics , CDx Machine learning : Scikit learn , Keras , Tensorflow Bioinformatics Data Analysis : Next generation sequencing Programming Languages : python , R , SQL , matlab , unix shell Biological Experiments : FACS , NGS library preparation , Cell Biology Experiments , Molecular Biology Experiments , Mouse Genetics . Technologies :
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Principal Computational Biologist . https : www.bluestargenomics.com . Seasoned computational biologist with strong knowledge and experience in data analysis and experiment design for high dimension data , including : NGS , microarrays and proteomics technologies . Excellent working experience in the area of liquid biopsy , target identification validation , drug MOA , patient stratification and biomarker identification . Excellent skills in R , Perl and Java . . Technologies :
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Computational Biology Researcher . Lead an independent project investigating how Xenopus laevis tadpoles identify physical deformity in others of their species , through a computational analysis pipeline . This research was funded by one of two 2020 2021 Arnold O. Beckman Scholarship awards at Tufts University Mar. 2020 Oct. 2021 Use state of the art computer vision software Ethovision XT15 to track movement and behavior of 30 tadpoles Design a robust Python program to identify collisions among tadpoles from noisy coordinate location data , calculate and report metrics of aggression in tadpole collisions , and visualize results Create Python scripts to split and clean 1,600,000 line data files , automate ImageJ image analysis and data collection , and organize files and directories for own research and to assist doctoral and post doctoral colleagues Present research at lab meetings , in written manuscripts and course papers , and in a poster at the 2021 Arnold and Mabel Beckman Foundation Symposium . . Technologies :
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Research Director . . Application of machine learning and statistical physics methods in biophysics , structural and systems biology .. Technologies :
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postdoc . . I am a cell biologist with a PhD in Biophysics , looking for new challenges outside the ivory tower of basic academic research . For over 10 years I have studied the microtubule cell skeleton along with it 's associated motor proteins . I am a passionate electron microscopist and have vast experience in Cryo EM as well as the subsequent image processing . When I sit in front of the microscope it feels like home . My work culminated in successfully completing projects determining the structures of Dynactin and Kinesin 8 . In my last project I focused on light microscopy techniques with optical trapping and TIRF microscopy . So that I will be able to link functional data with structural information .. Technologies : CryoEM
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proteins;structure
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Head , Exploratory Statistics , AbbVie Bay Area . . Translational data scientist with extensive experience in bioinformatic statistical analysis of genetics genomics proteomics data and biomarker research in biotech pharmaceutical companies . Experienced leader in building and managing productive bioinformatics biostatistics teams . Currently focusing on biomarker data analysis for discovery and clinical trials in Oncology . Specialties : biomarker data analysis , statistical genetics , omics data analysis , survival analysis , machine learning , statistical consulting , experimental design , algorithm development , software development , oncology , autoimmune disease .. Technologies :
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Assistant Professor . Institut de Biologie Structurale Guy Schoehn group Structural analysis of hantavirus replication by cryo electron microscopy . . Technologies : CryoEM
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proteins;structure
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Principal Scientist , Bioinformatics . . . Technologies :
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QC Scientist in General Chemistry . . Over the past 13 years my professional experiences have given me technical , interpersonal and organizational skills . I have experience with managing projects , planning and conducting development and validation studies , technical transfer of analytical procedures , CMO collaboration as well as process validation . I have several years of experience with GMP , ISO13485 and compliance . I have worked with immunology from antibody production to characterization , as well as been responsible for several types of immunochemical and biochemical methods . I have a high quality mindset and an analytical approach to my tasks . I am used to plan , prioritize and execute my tasks to meet the agreed schedule and quality . I have a positive mindset , easy to get on with , flexible and reliable . I enjoy working with people and get inspired by being a part of a team , find solutions as well as learning new things . . Technologies :
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Senior Computational Scientist . . Professional computational scientist software engineer with 20 years of experience developing software for scientific , medical , and imaging applications from the user interface level all the way down to hardware interfaces . I completed a master s degree in biological sciences biotechnology in 2012 and have since gained valuable experience in bioinformatics , computational biology , cloud computing , automation , robotics , and database technologies .. Technologies :
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PHD Student . Membrane protein biochemistry Cryo EM single particle analysis of membrane proteins Trainee supervision . . Technologies : CryoEM
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membrane proteins;structure
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Staff Scientist , Research Informatics . Collaborate with researchers and provide support of genomic data analysis for basic research and translational studies , including NGS data analysis , data mining and interpretation , publishing manuscripts and writing grants . Research and implement translational research informatics platform , enhanced tranSMART by integrating with patient data in i2b2 and Machine Learning . Investigated on the computational deconvolution method using DNA methylation data for tumor profiling analysis . managed the research IT infrastructure which includes scientific software , LIMS Lab Information Management System , high performance computing infrastructure , and cluster storage resources . . Technologies :
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Postdoctoral Researcher . Cryo tomography and subtomogram averaging . I am a Structural Biologist with expertise in molecular biology , protein biochemistry , single particle cryo EM and related computation especially image processing , model building and refinement in electron density maps . Dabbling in FIB milling , cryo tomography , subtomogram averaging .... Technologies : CryoEM
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proteins;structure
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