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Senior research associate . Negative staining Cryo EM Production , purification et cristallisation de prot ines recombinantes Responsable plateforme de production en organisme procaryote . . Technologies : CryoEM
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proteins;structure
|
Postdoctoral Research Scholar . . I am currently working as a postdoctoral fellow in James Hurley 's group at Berkeley . I am focused on dynamic protein complexes and how they confer function . Currently in the context of autophagy initiation using Cryo EM , Cryo ET , cell biology and Cryo FIB SEM approaches .. Technologies : CryoEM
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structure
|
Senior Principal Bioinformatics Scientist . Lead technical teams responsible for real time software on DNA sequencing instruments , instrument control software for breadboards and prototypes , and compute hardware Received 2022 annual innovation award for signal processing improvements to primary analysis software Present technical roadmap proposals and updates for on instrument software to executive leadership team Contributed to the development of a strong software patent portfolio in the areas of signal processing , patterned flowcells , and AI ML for sequencing Program lead for the integration of Emedgene team and technology . I am a senior leader with over 15 years of experience building and mentoring technical teams , bringing early stage technology development to market , and leading strategic programs . My technical work on image and signal processing and compute hardware at Illumina has enabled the sub 1,000 genome and been recognized with a company wide , annual innovation award . I also led the post acquisition program that integrated Edico and ultimately led to DRAGEN becoming the most efficient and accurate secondary analysis of sequencing data . Specialties : Instrument control , system simulation , primary analysis , DNA sequencing , image processing , computational chemistry , molecular modeling , high performance computing , algorithm development , technical lead , program lead Keywords : John Vieceli , San Diego , Illumina , Biotech , Scientific , Engineering , Next Generation Sequencing , NGS , Genetics , Genomics , Software , Bioinformatics , Image Processing , Scientific Computing , Algorithm Development , High Performance Computing , Computer Science , GPU , FPGA , SIMD , AVX , AVX2 . Technologies :
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Data Scientist Statistician . Data Scientist and Statistical Consultant in the Bay Area . As a contract consultant , I use my background in applied statistics , Bayesian modeling , and Machine Learning to model corporately owned data sets . . . Technologies :
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Professor . . I started my research career at Uppsala University where I in 2006 received a PhD degree for the bioinformatic discovery of 24 human receptors and the overall receptor repertoires in dog , mouse , rat and chicken . In 2006 7 , I was at the European Molecular Biology Laboratory EMBL Bioinformatics Institute where I developed a global protein informatics standard and data exchange format for protein affinity reagents . In 2007 2008 , I made another postdoc at GlaxoSmithKline where I conducted computational drug design and developed chemogenomic methods for ligand drug discovery . Since late 2008 , I have been at the University of Copenhagen where I have expanded my research to scientific database development , data science and experimental structural biology . My research focuses on G protein coupled receptors GPCRs the most abundant targets of physiological hormones and neurotransmitters as well as therapeutic drugs . My group develops computational and data driven methods for interdisciplinary receptor research and drug discovery , spanning : Biased signalling towards safer drugs and specific signalling probes Computational drug design Data science approaches to uncover receptor function Experimental structural biology The online research infrastructure GPCRdb . Technologies :
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membrane proteins;structure
|
Scientist . Building on the accomplishments of my 1st year at OXGENE , I am conducting more independent and in depth research in the field of promoter and enhancer discovery as well as experimenting with other molecular aspects impacting the regulation of transgene expression and its specificity in the context of gene therapy . . R D Scientist keen on conducting practical , independent , in silico to bench biological research that combines high volume data analysis with follow up wet lab validation . Particularly interested in computational biology and the field of multi omics . Concurrently with my main job responsibilities , I am developing and optimising bioinformatic pipelines for epigenetic and single cell assays as well as experimenting with machine learning , Nanopore and PacBio sequencing data .. Technologies :
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Senior Research Scientist . Assay development to support different projects within our different disease areas . Three years of experience of CETSA , from building of assays to delivery of data . Two years experience of assay build and data generation for a PROTACs project . . . Technologies :
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molecular glues;developing
|
Principal Researcher . Technology development bispecific antibody screening and microfluidics . Concept generation and project management . born as Achim Boltz . Technologies :
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antibodies;screening
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Patent Scientist . . . Technologies :
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Biomedical Engineering Society Advisor . . Digital and audio signal processing Improve noise robustness of auditory system model for word recognition in presence of challenging background noise Algorithm optimization Signal processing and statistical analysis Speech and natural language processing Experienced in clinical studies and algorithm development Strong knowledge of Biomedical sensors and systems for measuring physiological signals . Technologies :
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Scientist . Lead of the A eta Project from high throughput screening to Lead candidate molecule selection . Design of high throughput experiments , data collection and analysis of C. elegans phenotypes for drug discovery approaches in both Alzheimer s and Parkinson s diseases . Trained new staff with less experience and maintained effictive communication . Developed new Metabolic and Biochemical assays specific for different custom made C. elegans strains expressing target proteins : A eta , Syn , IAPP , TDP 43 and Tau in muscle and neurons . I am a hardworking , enthusiastic and goal driven researcher with five years of experience in Industry and Academia currently working as a Scientist and Visiting scientist at Wren therapeutics and The University of Cambridge , UK . Previously , I was a Research Student at the University of Nottingham , Queen s Medical Centre and also worked as a Research and Teaching Assistant at the North South University , Bangladesh . I am passionate about research in the field of Biochemistry and I am seeking to gain professional experience and develop enhanced skills . Effective team player as I have been part of the STEMNET group ; who steps out , adapts to different roles to achieve targets . The research projects I have been involved so far are focused on : a Cell membrane biology , mostly focused on membrane proteins ATP binding cassette G2 ABCG2 structure and functional analysis . b Expression of ABCG2 in Insect cells sf9 through the infection by baculovirus and generation transfected BiiC stocks . c Bacterial Cell culture , antibiotic resistance and biochemical analysis . d Proteomics , Protein modelling , Structural Biology and Molecular evolution through Bioinformatics . e C. Elegans study for drug discovery and development to cure Alzheimer 's and Parkinson 's disease .. Technologies :
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idps;proteins;expression;interaction;screening
|
R D scientist immuno oncology reseacher Nanomedicine researcher . I am conducting research on the efficiency of drug loaded nanoparticles in cancer therapy . I am also determining nanoparticles induced immune response and examining the presence of immune cells in tumors . My project focuses explicitly on a polymer based nanoparticle delivery system in tumor bearing mice . We use breast cancer , cervical cancer , and colorectal cancer xenograft patient derived PDX as well as cell lines models to develop passive or active targeted therapy . I am investigating the accumulation and pharmacokinetics of nanoparticles in animals . I also examine the toxicity and anti cancer efficacy of drug loaded nanoparticles in pre clinical models . . PhD in cancer nanomedicine and oncoimmunology I believe in leveraging scientific expertise , analytical skills , communication , modern technology , and professional network to propel success . I have experience on working with different stages of drug development . I have been a part of many successful collaborations with our national and international collaborators . I drove some interesting projects during this time and built good relations with our partners . 13 years of scientific experience within oncology , nanomedicine , Immunology , Neurodegenerative diseases , Gestation biology , Hematology , Respiratory physiology and Pathology . Developed extensive network of HCP KOLs in different medical fields . Knowledge and understanding of ICH GCP , clinical trials , drug discovery , drug safety and pharmaceutics . Proven ability to make valuable contribution to the team strategy through key insights and experience gained from the field . Additional education in healthcare innovation and entrepreneurship from BI Norwegian Management School and University of Oslo . Acquired knowledge in important entrepreneurial aspects , including market research , regulatory affairs , stakeholders customer needs , financial aspects , business plans , smart risks , and revenue generation . Ability to contemplate commercialization of research idea discovery . Trained medical students : Respiratory biology , Hematology , Immunology . Extensive experience in writing scientific articles and grant applications . Key skills : Scientific expertise , business acumen , emotional intelligence , active listener Problem solving and conflict resolution through teamwork , collaboration , and relationship building Networking and relationship builder , communication and presentation skills . Influence , persuasion , confidence , optimism , patience , time management Microsoft Office , PRISM , Adobe Illustrator , Photoshop , InDesign , Image processing softwares . Documentation , record keeping SOPs , Data management Flexible , agile , multicultural , teaching and training Certificates in GCP , Project Management Foundation , Health Innovation and Entrepreneurship , Project Management : Healthcare Projects , CAREiN .. Technologies :
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Application Scientist . Expertise in chromatography and multi angle light scattering , high throughput dynamic light scattering , field flow fractionation , differential refractometry and differential viscometry . Method development for chromatography FFF , SEC , IEC Expertise in analysis of viral vectors , proteins , polymers and particles by light scattering . Presentation of analytical methods and systems Hardware installation Customer support . Application Scientist in the field of chromatography and multi angle static light scattering , high throughput dynamic light scattering , field flow fractionation , differential refractometry and differential viscometry . Expertise in analysis of viral vectors , proteins , polymers and particles by light scattering . Furthermore , knowledge in structure based protein design , expression and purification of proteins , optogenetics , analytic characterization , and interaction studies . Moreover , I was involved in project management , supervision of students and employees , cooperation with international working groups US , UK , SWE , FIN and presentation of results in front of an international audience .. Technologies : SLS DLS
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carriers;expression;screening
|
Production Data Scientist . Perform data analysis for production support and failure investigations Maintain and develop new tools data retrieving scripts and visual dashboards to expand company s SPT Statistical Process Trending program Maintain and develop Minitab macros for generating trend graphs with control limits based on historical data analysis . . Technologies :
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Staff Scientist . X ray crystallography Cryo EM protein Production Single domain antibodies nanobodies Phage Display . I come from a multi disciplinary background with 15 years scientific experience obtained in internationally renowned research institutes . I have published my research in highly ranked scientific journals and won awards at both European and International conferences . As both an independent research group leader and now as staff scientist I am accomplished at managing multiple projects and personnel and in developing new projects using cutting edge molecular and biochemical techniques . . Technologies : Xray;CryoEM
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antibodies;proteins;interaction;structure
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Associate Professor . . Structural studies of membrane proteins and protein complexes by cryo electron microscopy and X ray crystallography .. Technologies : Xray;CryoEM
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membrane proteins;proteins;structure
|
Integration Scientist 1 . . Experienced Systems Integration Scientist with a demonstrated skillset in Next Generation Sequencing Technologies , Product Development , Laboratory Robotics , Bioinformatics , Ad hoc and Reusable Data Tools Development , and Project level Data Management . I thrive in the grey area between product developmental teams to help identify and improve developmental gaps inefficiencies , increase multidisciplinary team communication and collaboration , and develop best in class sequencing technologies .. Technologies :
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PhD Fellow . . Driven by the passion of doing science for a purpose . Protein biochemist and structural biologist with 9 years of experience working on various multidisciplinary projects with a focus towards pharmacologically relevant protein targets . Acquired extensive research experience in different labs around the world Asia , North America and Europe . Skilled in expression plasmid optimization , protein purification using the AKTA systems , structural determination using X ray crystallography and cryo EM , biophysical and biochemical analysis of protein function and interactions , data analysis and effective scientific communication . Highly passionate about working in the pharmaceutical industry with the end goal of contributing towards patient relief and effective prognosis .. Technologies : Xray;CryoEM
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proteins;characterization;expression;interaction;structure
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Senior Bioinformatics Developer . Develop pipelines for bioinformatic analysis of high throughput sequencing data , databases for metadata management . . Gordon Brown passed away July 2021 . I am his sister , Lynn ; I have been unable to close the account so far but wanted to let people know that he is no longer available for jobs . Thanks , Lynn Brown . Technologies :
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Senior Principal Scientist , Group Lead , Tranlational Bioinformatics and Sciences . . A highly self motivated computational professional with multi disciplinary expertise . Extensive experience on designing computational approaches and bioinformatics solutions to support translational programs in Rare , Neurological , Immunology Inflammatory disease areas . Strong expertise on applying data mining , machine learning , statistics and network approaches on large scale heterogeneous omics data integrative and predictive analysis for drug discovery . Led and supported for over 80 projects under different drug discovery and development stages in Sanofi Genzyme , including disease mechanism understanding , drug target discovery validation , target indication expansion , drug MOA , biomarker identification , patient stratification , and drug repurposing . Experienced on informatics tools system design and development . Author and reviewer of a number of publications on renowned bioinformatic journals , book chapters and IEEE conferences . Works have been reported by various public medias such as ScienceDaily and European Orphanews . Specialties : Translational Bioinformatics Computational Biology Data Sciences Research Informatics Natural language processing with text mining tools Programming skills on JavaScript , R , Perl , Python , SQL . Informatics tools design and development High performance and parallel computing Data Visualization . Technologies :
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Senior Director of Process Development . . Areas of expertise include : . Product and Technical Support : . process of manufacture of existing and new products . new technology introduction , development , process improvements , GLP and GMP compliances . creation of study plans , SOPs required for manufacturing , production batch records and reports for product related activities . execution and assessment of process data and correction of production issues . R D and analytical dept . execution of developmental trials , design of experiments . process and technology transfer to multiple international partners . train operators and other personnel on new technologies . co ordination and organisation of large team of scientist for GLP studies . Quality Control : . lead process team investigations into failures out of specifications ensuring corrective actions are implemented . responsible for upholding departmental quality compliance standards . provide support and review process for validation documentation . Reporting and Communication : . generation and presentation of bimonthly progress reports and annual reports to CSO and CEO . assessment and cost analysis on processes and equipment . EU consortia meeting and conference presentations . Immunological techniques : Flow cytometry BD FACSCanto , Calibur , Aria II , Miltenyi MACs Quant and Tyto , mixed lymphocyte assays immunosuppressive and immunogenicity , MACS sorting , alloantigen recall responses , alloantibody assays , cytotoxic T cell assays , phagocytosis assays , ELISA , histology H E . Cell Culture techniques : Isolation , culture , cryopreservation and characterisation of primary cells and cell lines . Molecular Biology and Virology techniques : RT PCR , PCR array , cloning , Adenovirus and Lentivirus production concentration titration , cell transduction and transfection . In vivo techniques . Data Analysis : FlowJo , GraphPad Prism and Excel . . Technologies :
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Scientist I . . Biochemistry Ph.D. scientist Lab Bench Skills : Protein preparation and purification , NMR , AKTA chromatography , chromatographic methods : metal affinity ; ion exchange ; size exclusion , SDS PAGE , DNA cloning site directed mutagenesis , molecular biology , Gibson assembly , mammalian cell culture , bacterial cell culture esp . E. coli , sterile technique , PCR , RNA isolation , rt qPCR , LC MS , computational biology , Illumina next generation sequencing NGS library preparation Software : NMRpipe , Python , MATLAB , Pymol , Excel , Microsoft Word Human Languages : English native , French advanced . Technologies : NMR
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Instrument Scientist Lab Manager . At Bernal Bio Labs , I lead research on biopharmaceutical monoclonal antibody process development , and support cutting edge research through trouble shooting , data driven decision making , statistical design of experiments DoE , bespoke data visualization solutions R and Plotly , and simulation based upstream downstream process optimization using advanced statistical and multi physics approaches . . Additionally , I ensure that large equipment including bench top and pilot scale bioreactors Applikon and Eppendorf , fast liquid chromatography systems KTA Cytiva , HPLCs Agilent , and Mass Spectrometers are kept in functioning order . Finally , it is also my responsibility to ensure that the laboratory facilities are kept safe , organized , and well stocked . . I am a result oriented scientist and bioprocess engineer with a strong mathematical and statistical background , experienced in upstream and downstream biopharmaceutical process development , Quality by Design tools , statistical design of experiments DoE , and simulation based optimization . I have experience leading international research teams and I can speak English , German , and Portuguese fluently . After having concluded my B. Eng . Hons in Bioprocess Engineering and Biotechnology with the highest GPA of the year , I was awarded a competitive scholarship to pursue a doctoral degree at the prestigious Max Planck Institute in preparative chromatography simulation and optimization , which I concluded with highest honors Summa cum Laude . I was then awarded a highly competitive post doctoral fellowship at the University of S o Paulo to apply simulation and Quality by Design tools including Bayesian inference and Design Space mapping in the development of the biopharmaceutical anti leukemic enzyme L asparaginase for the Brazilian public healthcare system , during which time I also established cooperations with the Universities of Cork and Loughborough . I now work as instrument scientist lab manager of the Bio Labs in the Bernal Institute University of Limerick , where I lead cutting edge research on monoclonal antibody purification , Bayesian modeling of bio pharmaceutical processes , and simulation of mRNA vaccine production processes . Additionally , I support the research of the Bernal Bio Labs users through the statistical design of experiments , data driven decision making , data interpretation , and visualization , as well as simulation based optimization . Furthermore , I also ensure that the laboratory facilities are kept organized and safe , while also maintaining laboratory equipment in working conditions . . Technologies :
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antibodies;biologics;screening
|
Director Of Bioinformatics . . Experienced leader growing high performance teams , managing change , and working in a fast paced biotechnology industry . Strong research professional skilled in Next Generation DNA Sequencing , Bioinformatics , Data Science , and Biotechnology .. Technologies :
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Director , Integrative Genomics and Bioinformatics Core . . Experienced Bioinformatics Analyst with a demonstrated history of working in the research industry . Skilled in the analysis of all types of nucleic acid sequencing , proteomics , and other high throughput quantitative technologies . Strong research professional with a Doctor of Philosophy Ph.D. focused on Quantitative Computational Biology from Princeton University . . Technologies :
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Head of Bioinformatics . . Advances in medical technology has created opportunities for major discoveries in scientific medical research , and raised hopes for potential breakthroughs in diseases such as cancer . This ongoing progress has stirred up much excitement and anticipation among professionals in the medical and scientific research community , myself included By combining my leading edge knowledge and expertise in the areas of gene technology , computational genetics and genomics , and genetic epidemiology , with state of the art technology and methodologies , I have made significant headway in various stages of medical research . As the CTO of a genetic testing company , I have made leaps of progress in developing a wide range of cutting edge genetic testing products , focusing on personalized medicine , disease risk prediction , personalized nutrition , and inborn talents , including leading the research on the validation of warfarin pharmacogenetic algorithms through a recent publication . From a business management standpoint , my systematic , yet flexible approach to meeting challenges has enabled me to effectively engage in handling multiple concurrent projects , such as dissertations , publications , public presentations , patents , and working with interdisciplinary teams toward higher performance standards for enhanced accuracy , efficiency , and productivity . As a seasoned and confident communicator , I possess the natural capacity for bringing people together in achieving common purposes ; including cultivating a culture and environment that encourages , nurtures , and rewards excellence , while emphasizing team cooperation . It is thus with a healthy dose of optimism that I welcome opportunities for applying my cross functioning skills and abilities across a broad range of key roles , and developing mutually beneficial partnerships for advancing scientific and medical research , technological development , and business growth . Technologies :
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Staff Scientist . Molecular Graphics Laboratory Department of Molecular Biology , MB 5 The Scripps Research Institute http : mgl.scripps.edu . After 3 years of studying in the university Paris 5 to earn my Doctoral , I acquired skills in molecular modeling , in particular the structural study of protein protein study , in order to develop new therapeutic agents for the blood coagulation disorder . I was in a position at the university Paris 7 for 2 years , combining teaching and research in the fields of macromolecular assembly at the structural level including the application of current methodology and development of new methods . I was a postdoc at The Scripps Research Institute TSRI in the Molecular Graphics Laboratory MGL , working toward a better interaction with macromolecules tangible interface , augmented reality , 3D rendering , etc . . I am now a staff scientist at The Center for Computational Structural Biology CCSB created in 2018 as a successor of the Molecular Graphics Laboratory . I am the lead developer of ePMV , cellPACK and cellPAINT . https : ccsb.scripps.edu http : epmv.scripps.edu http : autopack.org https : ccsb.scripps.edu cellpaint Specialties : bioinformatic , molecular modeling , molecular docking , molecular graphism . Technologies :
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Research Fellow . . I am a computational biologist , with more than 10 years professional experience of high quality scientific research at the intersection of molecular biology , computer science and statistics . My current research activities predominantly involve the development and application of biostatistics and machine learning methods regression , classification , supervised and unsupervised learning to a broad range of molecular and clinical datasets . Specialties : Bioinformatics and computational biology ; NGS data analysis ; sequence analysis ; protein function prediction ; structural bioinformatics ; statistical data analysis ; machine learning ; design and analysis of algorithms .. Technologies :
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Researcher Cryo Electron Microscopy , Brichos Domains , Alzheimers Disease . Department of structural biotechnology at School of Technology and Health Associated at KI Dept Bioscinence and Nutrition and Neurobiology , Care Sciences and Society . I started my career as a musician cellist . Due to scoliosis , I had to give up this profession , but I was lucky to be able to change into the exciting field of life science and electron microscopy . From 20170601 : Structural determination of the Bri2 BRICHOS domain Alzheimer s disease AD is a fatal neurodegenerative disorder , where amyloid plaques , manly from the amyloid 42 A 42 , accumulate in the brain . The Bri2 BRICHOS domain has a physiological role in delaying A 40 and A 42 fibril formation and toxicity in vitro and in vivo . The anti amyloid chaperone activity of Bri2 BRICHOS makes it a promising treatment strategy for AD . The aim of the project is to obtain high resolution structural data from the Bri2 BRICHOS domain . Collaborators : Jan Johansson , Center for Alzheimer Research , KI ; and the group of prof . Hans Hebert , Department of Biosciences and Nutrition , KI , and School of Technology and Health , KTH Royal Institute of Technology , Novum , Huddinge . Novel 3D electron density maps are recently obtained . Further structural studies via high resolution single particle and cryo electron microscopy techniques will be performed . 2010 20170531 : Molecular structure , packing and release of gelforming mucins with relevance to Cystic fibrosis In many diseases , such as different inflammations in the airways and intestine , the expression of mucins is altered . In CF an extremely viscous fluid is built up . Understanding the N terminal calcium and pH dependent mechanisms of packing and secretion of mucins may be helpful in designing novel therapeutics . Collaborators : Gunnar C. Hansson mucin biology group , University of Gothenburg , Sweden ; the group of Hans Hebert , Karolinska Institutet KI and School of Technology and Health , Royal Institute of Technology , Huddinge , Sweden , Novel 3D electron density maps were recently obtained for all gel forming mucins . . Technologies : CryoEM
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idps;structure
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Scientist Immunology and Microscopy . Assay development , Characterization and validation of engineered therapeutic antibodies , In vitro functional assays Eg . ADCC , CDC . . Dynamic and ambitious professional with 10 years of experience in research and life science industry in bioassay development and quality control . I m highly organised and skilled in building up cross functional teams . Colleagues describe me as well organised , reliable and efficient co worker . In my free time , I teach Yoga for beginners . Administrative and Quality : Project management , Creative and problem solving , technical report writing Industrial production and quality control : cGMP , SOP , QMS , ISO 13485 , regulation and guidelines . Technologies :
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antibodies;characterization
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Senior Chemist . Support for filling and freeze drying process team , Aseptic Production Class A B facility . Work with deviations , CAPAs and change controls related to products and processes . Write standard operating procedures SOP , work instructions WIN , production documentation master formula production formula . Aseptic process simulation APS . Process optimisation projects , single use materials , cleaning monitoring and trending , APS strategy , product and process risk assessments . . Specialties : Aseptic filling of vaccines Class A B facility , freeze drying , APS , risk assessment , trending . API Production of biological diverse products for immunotherapy , unit operations , PQR , CPV , deviations , change controls , production documents , equipment qualification . Synthetic organic chemistry , Parallel chemistry , Drug discovery , Hit to lead optimization , Medicinal chemistry , Lead optimization of small molecules , GPCR nuclear receptor targets within CNS , nephrology and dermatology , Evaluation of IP space , EHS , Coordination of research outsourced to CRO . I am author co author of 15 publications and 6 patent applications . Technologies :
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Statistics consultant . Biostatistics consulting and teaching for pharmaceutical and biotechnology companies in clinical trials , molecular diagnostics , medical devices and drug development . My work has led to FDA and CLIA approvals , articles in the New England Journal of Medicine and in Lancet , many patents , and products with several hundred million dollars in revenues . Biostatistics consulting for venture capital companies to evaluate investments in life sciences . Work with life science start ups to obtain funding . Advise on corporate strategy and product development . . Statistics consulting for clinical trials , pre clinical studies and basic research in pharmaceuticals , diagnostics , and devices .. Technologies :
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Director of Bioinformatics . Developed Next Generation Sequencing NGS bioinformatics pipeline infrastructure for clinical diagnostics . Developed custom software for variant filtering , annotation and interpretation support . Supervised bioinformatics production . . Self driven , goal oriented bioinformatics software developer , data analyst , systems integrator and technology strategist with passion for detail and quality . 18 years bioinformatics group leadership management mentoring and infrastructure planning and implementation . 7 years Next Generation Sequencing data analysis and software development Bash , Java , Scala , Perl , Python . 18 years bioinformatics analysis and application of biomedical databases NCBI , UCSC , HGMD , OMIM , etc . . 27 years data analysis and analytical software development C , C , Java , Scala , Perl , Python , VBA , MATLAB , R . 16 years laboratory database and information system development MySQL , MS SQL Server , MS Access . 12 years research manuscript and grant authoring , and internal and external results presentation . 6 years development and management of SOPs and documentation for CLIA and CAP certification .. Technologies :
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Manager , Application Scientists . . I am an Applications Engineer Life Sciences with expertise in Cryo Electron Microscopy . I am also a Structure Biologist with an interest in virus structures , virus receptor and antibody interactions and cell entry . My main interests include structure based vaccine design , epitope mapping , antivirals , virus receptor interaction and cell entry using high resolution CryoEM , FIB milling and Electron Diffraction , X ray crystallography , among others . . Specialties : Structural biology , Cryo electron microscopy , X ray crystallography , microED , molecular biology , biochemistry , protein structure and function , molecular graphics . Google Scholar : Abhay Kotecha . ORCID : 0000 0002 4480 5439 . Research gate : Abhaykot . Technologies : Xray;CryoEM
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Graduate Research Fellow . Awarded the National Institute for General Medical Sciences NIGMS Initiative for Maximizing Student Development IMSD Fellowship at UCSF . IMSD is designed to support historically underrepresented and marginalized PhD students in basic science graduates programs . Currently performing a summer rotation as a Biological and Medical Informatics PhD student . . I am PhD Student at University of California San Francisco and I have a diversity of work experience that makes me particularly well suited to a variety of research or technological support positions . While on the job , and in my studies , I have learned the value of building trusted relationships with both team members and customers alike . Additionally , I approach every professional encounter with a high level of curiosity , positivity , and fervor for finding robust solutions . I have extensive experience delivering service : over the phone , remotely via network , in store , and without managerial oversight . Ultimately , I attribute my technical insight and research abilities to the extensive training I received under my mentors from leading academic institutions and to my personal dedication to understanding the world around us . I believe I would make a great addition to any team as I have a genuine interest in serving people and in finding ways for advanced knowledge to benefit us all .. Technologies :
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Assistant Research Professor . . Experienced Assistant Research Professor with a demonstrated history of working in the higher education industry . Skilled in Materials Science , Transmission Electron Microscopy and Cryo Electron Microscopy , Nanotechnology , UV Vis Spectroscopy , and Powder X ray Diffraction . Strong research professional with a Doctor of Philosophy Ph.D. focused in Materials Chemistry from the University of Minnesota Twin Cities . . Technologies : Xray;CryoEM
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PhD Student . . . Technologies : CryoEM
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Lead Scientist Research Development . Omics tecnologies for BioPharma . A highly self motivated and passionate Ph . D chemist with strong expertise in bioanalytical methods development , employing state of the art techniques : hyphenated chromatography mass spectrometry HPLC , UPLC , GC , MS and MSn using single and triple quadrupole MS , ion traps , Qq Tof , orbitrap for omics technologies in the fields of biology , chemistry and cultural heritage . I am currently working as lead scientist at Lonza Pharma Biotech applying LC MS based technologies for the characterization of biomolecules including protein therapeutics that continue to dominate the global pharmaceutical market and to grow significantly in the last few years . Turning academic ideas into commercial concepts , I am using top down , bottom up and middle down methods for enhanced protein characterization in terms of sequence determination , post translational modifications PTMs and higher order structure HOS analysis . Improvements in MS instrumentation along with improvements in ionization and dissociation methods that lead to high throughput high resolution MS based methodologies consist my main field of interest . During my undergraduate postgraduate studies I focused and specialized on : Proteomics Top down Bottom up proteomics Method development for protein extraction purification Liquid Liquid techniques , S trap , SPE columns , affinity resins Development of innovative kits with extremely high sensitivity for characterization of proteinaceous materials Protein characterization and quantitation by UV Vis spectroscopy , size exclusion hydrophobic interaction ion exchange chromatography , HPLC and LCMS Protein degradation with the investigation of Post Translational or chemical modifications with the use of bioinformatic tools Study of biochemical pathways Small molecule analysis Metabolomics Isolation and structure elucidation of secondary metabolites from natural sources or biological sources Development of analytical protocols for molecule extraction and latter characterization by mass spectrometry LC MS MS , GC MS or spectroscopic methods FT IR , Raman Development of UHPLC and LC MS methods for the quantification of small molecules in biological fluids or natural sources Validation of analytical methods according to the guidelines of FDA or EMA Pharmacokinetic studies in Natural Products Organic chemistry for drug design Techniques of organic synthesis and catalysis Isolation and purification of organic compounds by chromatographic methods Identification of organic compounds by NMR , GC MS , LC MS and FAR IR .. Technologies : NMR
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biologics;characterization
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Senior Scientist . Cell culture process development for expression of antibody mixtures that address multiple oncology targets in a single drug product . API coordinator . Project management and tech transfer to CMOs . Cell line generation , cell banking and upstream process development Process characterization and validation . Leading upstream process characterization study design . Regulatory filing , Module 3 Six Sigma black belt statistics : QbD , DoE , predictive modelling . Toolbox : JMP Pro , Python . Scientific Data Management System built with Azure Databricks . Responsible for automation scripts Python , PySpark , SQL and scientific data management strategy across CMC area . . Experienced in Cell line generation , upstream and downstream process development , tech transfer and manufacturing . Subject matter expert in CMC process data science , DoE and applied statistics . Data Science in the CMC area scientific data management system owner and project leader . Spearheading automation of data processes and statistical analyses across several scientific areas ; lab automation , data wrangling , visualization and predictive modelling . Toolbox : JMP Pro , Python , SQL , Azure , Databricks . API coordinator Project management and tech transfer to CRO CMOs . Regulatory filing , IND , BLA Six Sigma Black Belt statistics . DoE approach to process development and statistical process control for manufacturing . Cell line generation and cell banking Upstream and downstream process development and manufacturing . Process characterization and validation . Leading upstream process characterization study design , execution and reporting .. Technologies :
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Postdoctoral Research Fellow . . My long term research goal is to explore molecular drivers of disease at the interface between structural biology , biophysics , and biochemistry . Specifically , I aim to investigate the structure of disease related protein complexes to inform cellular studies and functional assays that guide drug development . In my graduate work , I combined structural biology , protein chemistry and biochemistry to explore the intricate interactions between chromatin binding proteins and the nucleosome , the fundamental repeating unit of chromatin and a robust regulatory hub that modulates the activity of numerous nuclear proteins . These transient interactions are frequently misregulated in cancer , and essential binding surfaces at these interfaces present an exciting opportunity as new therapeutic targets . My postdoctoral research has expanded my skillset into the field of membrane proteins , in which I combine single particle cryo EM and cryo ET with single molecule biophysical techniques to investigate the native architecture and arrangement of AMPA receptors , essential excitatory neurotransmitter gated ion channels that contribute to tumor growth and invasion in brain cancer . Research specialties : Cryo electron microscopy single particle cryo EM and cryo ET Confocal laser scanning microscopy LSM High performance liquid chromatography HPLC Fluorescence detection size exclusion chromatography FSEC Protein expression and purification recombinant and from native tissue Characterization of protein protein interactions using single molecule and population based biophysical assays Biochemical characterization of enzymatic activity Molecular biology 3D printing protein structures and other useful lab items Publications list : https : orcid.org 0000 0003 2334 3957 Outside of the lab , I love doing anything outside but especially playing soccer , hiking , and backpacking , music violin guitar , and travel .. Technologies : CryoEM
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nucleic acids;proteins;characterization;interaction;structure
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Research Specialist . . . Technologies :
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Associate Scientist Target Discovery . Identify and characterize novel disease relevant targets in the following areas : . osteoarthritis , rheumatoid arthritis , polycystic kidney disease . Scientific responsibilities Develop phenotypic assay models ; perform , analyse and report experiments ; scientific literature research . Key Techniques Technologies : Fluorometric , luminescent and colorimetric readouts ; Protein quantification ELISA , MSD ; Immunocytochemistry ; mRNA profiling qPCR , QuantiGenePlex ; Cell culture . . . Technologies :
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proteins;small molecules;characterization;screening
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Computational Chemical Biologist . . . Technologies :
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Senior Principal Quantitative Scientist . . . Technologies :
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Bioinformatics and Data Science Analyst Consultant . project based bioinformatics analysis , support , and engineering currently an RNA seq , circularRNA circRNA , pathway analysis , scRNA seq cancer normal cell classification . Software Bioinformatics Engineer interested in growth opportunities : bioinformatics , software engineering , info . security assurance , Machine Learning . 10 years bioinformatics support in Govt . Academic settings . Specialties : BioInformatics . Technologies :
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Researcher . David Liu Lab : Evolution of biochemically optimized orthogonal transacting inteins . Molecular dynamics MD investigation of spCas9 biotechnologies . . I am fascinated with leveraging the physics and chemistry of biomolecules to engineer molecular biotechnologies . As a junior at MIT I am majoring in chemistry and computer science and minoring in physics . This integrated scientific toolkit allows me to investigate biomolecular systems from a first principles approach and tailor computational methods to address new challenges arising in the fields of computational chemistry and biology . For example , after entering college I discovered molecular dynamics MD which is a computational chemistry technique that allows me to simulate high molecular weight proteins and investigate conformational dynamics at an atomic level of detail . I have since used MD in the David Liu Lab to develop models of CRISPR Cas9 therapeutic activity based around recognizing previously undiscovered details of Cas9 s conformational dynamics . In addition to physical chemistry I am interested in understanding evolution as a process for generating immense diversity in the function of biomolecules from functionally distinct starting material . In particular I am inspired to direct the evolution of proteins utilized in genome modification to select for precision and selectivity in their activities .. Technologies :
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Research Associate . . Cryo electron microscopist with 5 years of experience in cryo electron tomography of cells and tissues . Passionate about structural biology of macromolecular machines that are vital of sustaining life with a special focus on elucidations of their structures in their native context . Believe such studies will be of enormous help regarding future drug design . Technologies : CryoEM
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proteins;structure
|
Lab Manager Protein Purification . . Protein biochemist with a background in protein expression , purification and biophysical characterization of proteins and protein complexes . Thorough knowledge of high throughput methods applicable in protein science , as well as specialized approaches for more challenging proteins .. Technologies : BLI
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proteins;characterization;expression
|
Senior Scientist . Computational Proteomics , Bioinformatics , Mass Spectrometry based Proteomics . bioinformatics , proteomics , computational biology . Technologies :
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Associate Professor . . Cryo electron microscopy Marcomolecular Crystallography Structural Biology Membrane Proteins . Technologies : CryoEM
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membrane proteins;structure
|
Senior Bioinformatician Proteomics . . I am an experienced bioinformatics researcher with a demonstrated history of working in the area of mass spectrometry based proteomics and multi omics , like genomics , transcriptomics , metaproteomics , etc . I have recently earned my Ph.D. degree from the University of Minnesota . As part of my Ph.D. , I worked to address the issue of large protein sequence databases that we often encounter in a proteogenomics and metaproteomics data analysis . Also , developed several multi omics tools and workflows for the Galaxy Platform . I am actively contributing to the Galaxy community towards providing an accessible platform with tools and workflows for bioinformatics research . I am involved in developing and wrapping new tools and workflows , as well as wrapping existing bioinformatics tools to make it accessible through Galaxy . Additionally , I have also contributed to Bioconda by submitting Conda recipes for existing bioinformatics tools for easy dependency management . Skilled in Python , Perl , R , Bioinformatics , Genomics , Proteomics , Transcriptomics , Workflows . I have been in bioinformatics for 15 years now including my Bachelor of Science B.Sc . degree from India and Master of Science M.Sc . from India , 4 years of working experience in research academia focused in Bioinformatics , Master of Science MS degree focused on Bioinformatics and Computational Biology from the University of Minnesota , and Ph.D. focused on Bioinformatics tool and workflow development on Galaxy for Proteogenomics , Metaproteomics , and Quantitative Proteo Transcriptomics . . Technologies :
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Scientist . . Doctorate in Biochemistry with over eight years of analytical development and research experience . A productive and driven independent scientist that has strong technical writing skills and six publications . Advanced experience developing assays and analyzing amyloid protein interactions with small molecule drug targets , cholesterol , and liposomes through separation and spectroscopic techniques . Collaborated with other laboratory teams to solve complicated questions that led to scientific breakthroughs . Mentored junior scientists to be proficient leading to stronger collaborative teamwork and productivity . Detail oriented , organized , and solves difficult problems in a timely manner . Laboratory Skills and Techniques : Research , titrations , reflux , recrystalization , pH meters , buffer preparation , pipettors , analytical assay development , peptide protein synthesis , peptide protein purification and monomerization , gold nanoparticle synthesis , quantum dot synthesis , liposome preparation thin film hydration and extrusion techniques , peptide protein biophysical characterization , and inhibition quantification assays of peptide aggregation kinetics . Instrumentation : High performance liquid chromatography HPLC , mass spectrometry MALDI , FTIR and ATR , Raman , UV Vis , fluorescence and plate readers , atomic force microscopy AFM , dynamic light scattering DLS , circular dichroism CD , peptide synthesizer , and nuclear magnetic resonance NMR spectroscopy . Software : Origin , Gaussian , MFP 3D AFM software , Malvern Zetasizer , Agilent HPLC ChemStation , flexControl Voyager MALDI , ChemDraw , EndNote , and Microsoft Office Word , Excel , and PowerPoint .. Technologies : SLS DLS;CD;NMR
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idps;small molecules;characterization;interaction;screening;stability
|
Bio process developer Researcher DSP . Intravacc is an Institute of Translational Vaccinnology . Intravacc has a long history in developing vaccines . It promotes public health by developing vaccines from the laboratory to clinical study in man . To achieve this mission , our aim is to substantially reduce development risks and costs of new vaccines by bridging the translational gap between laboratory bench and market so in other words the gap between vaccine research done at Universities or sme 's and Industry . My work includes . Screening and setting up new processes for candidate vaccines , ranging from initial proof of concept using gradient cetrifugation , till scalable processes using more modern technologies . Volumes range from 1 . 5L till 100L. Setting up and implementation of a liquid handler for assay execution and HTPD work under BSL 2 . Screening new and old technologies for their potential use in processes and optimizing troubleshooting individual process steps . Optimizing a viral vaccine candidate and producing another viral candidate under GMP . . To paraphrase a bit I love to solve a problem wrapped in a mystery inside an enigma using modified old , current or experimental techniques and thrive at it . I currently work both on a farm dairy and in the pharma . My expertise lies with process development and purification DSP Downstream Processing both bacterial 1000L mammalian 1500L based . Scale up , scale down , intensification , troubleshooting optimization of production processes . All integrated with : Design of Experiment DoE , Quality by Design QbD , High Throughput Process Development HTPD , innovation techniques e. g. TRIZ , Lean for Six Sigma Green Belt , and Statistical Process Control SPC . Up to the GMP production of Clinical Material at maximum biosafety level 3 BSL 3 and transferring receiving processes to partners . Good theoretical knowledge of USP , cont processing . I modernized our current DSP lab facilities equipment and brought them into the 21st century and ready for beyond and was involved in the startup of a BSL3 vaccine production facility . Techniques include not limited to . Clarification NFF , centrifugation , precipitation flocculation , nano . Concentration CFF TFF , UC . Chromatography column , membrane , monolith . Inactivation Chemical , UV , thermal . Supporting laboratory infrastructure . Participating in qualification validation of equipment and process . My personality is best described by the acronym INTJ . I do not shy away from a challenge and have been involved in multiple successful court cases against the government , and recognized as a vaccine production safety expert . I 'm enthusiastic , driven , flexible , creative can think way outside of the box what box plunge in and do what is necessary , give 100 and continuously expand my skill set to overcome challenges presented . This led to several participations in scientific publications patents trade secrets conference participation presenting , oral , and posters . Due to my broader pharma biotech interest have a good overview of the current state of art , industry and can expand on it . Vaccines are a form of endogenous antibody therapy and the most complicated , widely available , cheapest biopharmaceutical with the highest possible safety built into them . There is indeed a small uncertainty on vaccines , but just because they can not deliver 100 safety , given how serious the disease risks are including a far higher risk from the actual virus , this is not a reason to not continue using vaccines . . Technologies :
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biologics;expression
|
Bioinformatics Scientist . . . Technologies :
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Bioinformatics Scientist . . Dr. Holman is a computational biologist with experience designing computational pipelines that apply machine learning , network modeling , statistical , and pathway analysis algorithms to mine high content datasets , including genetic , genomic , next generation sequencing and clinical data , to facilitate new drug target identification and development of genetic signatures applicable to patient stratification and diagnosis . He is experienced in both industry and academic settings , focused on drug discovery , translational medicine , and systems biology , with specific expertise in the neurobiology of HIV replication , and in silico selection of novel drug targets . He is fluent in general purpose programming and analysis languages including Perl , R and SQL , as well as domain specific analysis tools , such as Cytoscape , Hyphy and TopHat Cufflinks . Additionally , in the course of his work he has designed and implemented large SQL databases , both to facilitate in house research , and for deployment of the publicly available HIV Brain Sequence Database .. Technologies :
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Sr . Director , Head of Translational Bioinformatics . . . Technologies :
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Data Science Manager Machine Learning Group Lead . . . Technologies :
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Researcher PHD Student . . PhD student in structural biology using single particle analysis cryo EM to study viral polymerases . Dabbled in electron cryo tomography of viruses , nanodisc embedding and membrane proteins .. Technologies : CryoEM
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membrane proteins;structure
|
Principal Scientist . . Broadly trained and experienced Senior Scientist with more than 19 years of Pharma experience Experienced in laboratory management with proficiency in expression profiling by real time PCR , assay development , cell biology and antibody generation . Experienced project team representative with business writing , data presentation and project management skills . Confident , efficient , work independently and as a team player , willing to take on new challenges and acquire new skills . Technologies :
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antibodies;developing
|
Senior Scientist . . Accomplished and intuitive scientist who offers comprehensive experience in preformulation , formulation , product development and manufacturing Equipped with expertise in material properties , formulation development and manufacturing Apply cutting edge techniques to solve the problems Operate in a strong sense of urgency and thrives in a fast pace setting Area of Expertise : Preformulation form screen and selection Formulation and process development Amorphous formulation Continued process verification . Technologies :
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formulation
|
Postdoctoral Scientist . . I am a biochemist with 10 years of expertise and understanding of protein production , stability and structure with a focus on developing better drugs and therapeutics . I have received the EMBO Long Term 2 year grant for my current project . My current area of interest is the molecular organisation and interactions of transmembrane receptors that determine signalling events at the surface of immune , cancer and neuronal cells . I am a skilled project manager and a bench scientist with excellent command over scientific fundamentals and have a broad working knowledge . I am a specialist in a number of approaches , particularly mammalian cell culture ; High throughput biophysical assays including SPR , MST , BLI ; flow cytometry ; protein structure analysis ; protein purification and molecular biology techniques cloning , transfection , quantitative PCR , bio assay design optimization and small molecule drug discovery . I have key strengths in establishing collaborations , problem solving , independent thinking , thoughtful and careful execution of experimental work , ability to work on multiple projects in teams , developing daily work plans and keeping up to date with literature . I have written several research grants and international publications . I also possess great interpersonal , management , written and oral communication skills .. Technologies : BLI;SPR;MST
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membrane proteins;expression;interaction;screening;stability;structure
|
Principal Scientist . Principal scientist in BMS Infectious Diseases focusing on the discovery and development of antiviral therapeutics . Research efforts in my group are focused on the discovery and development of small molecule antivirals directed against multiple pathogens including HCV , HBV , Dengue and BVDV . Experienced in all stages of drug discovery from target selection to clinical nomination and first in human studies . In particular , played a key role in the discovery and advancement of HCV NS5A and NS5B inhibitors Daklinaza and Beclabuvir , including screen development , high throughput screening , target identification , mechanism of action studies and advancing leads through compound profiling and Phase 1 clinical studies . Expertise includes cellular and molecular biology , small molecule mechanism , biochemical and cell based assay development for compound identification and triage , biochemistry , genetics , and small molecule drug discovery process . . Technologies :
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proteins;small molecules;screening
|
Postdoctoral Researcher . Project : Alkylsodium reagents for organic synthesis in continuous flow . Continuous flow sodiation of benzylic and allylic C sp3 H bonds done with on demand generated hexane soluble alkylsodium base using a sodium packed bed reactor . Extreme nucleophilic nature of benzylic sodium species led to highly selective and efficient cross coupled products with alkyl chlorides and ring opening products with epoxides , oxetanes and aziridines . Developed a concise and sustainable synthetic route to Fingolimod Gilenya oral drug starting from commercially available p xylene with an overall yield of 45 . Efficient , passionate and purpose driven researcher with over 10 years of experience in organic synthesis and catalytic method development , continuous flow chemical synthesis , photoredox , small molecule drug discovery , medicinal , green organometallic and supramolecular chemistry . As a result oriented researcher , my passion and problem solving skills have resulted in over 11 publications in reputed journals including first authored high impact publications in JACS and Angewandte Chemie . As a lead author , I had proposed , designed and executed these projects which also reflects my skilled expertise and in depth knowledge in synthetic organic chemistry . . Working across laboratories in India , Hong Kong and Germany , I am highly adaptable collaborative and have strong teamwork , communication and networking skills . I have excellent standards of oral and written scientific communication skills as evidenced by the coveted Humboldt fellowship award along with several poster , oral presentation and travel grant awards in conferences across the globe . My leadership and mentoring skills were honed by supervising graduate and intern students towards project completion . . As a person constantly striving for innovative chemical solutions , I have worked in different areas of organic chemistry such as metal catalysis , asymmetric catalysis , supramolecular metal catalysis , highly reactive organometallic reagents in automation , photo catalysis and drug discovery research . Outstanding practical knowledge of product synthesis , purification and characterization skills . Expertise in multi step synthesis of small complex molecules . Skillful in purification methods : Flash column chromatography , crystallization , distillation and prep HPLC along with purity profile analysis of samples by GC , Chiral GC , LC MS and HPLC . Mastered sample characterization by NMR , Mass , FT IR , UV Vis Spectroscopy and Optical rotation . Expertise in packed bed reactor assisted highly reactive organometallic reagents synthesis in continuous flow . Experience in glove box and Schlenk line techniques to handle air sensitive compounds . Kinetics mechanistic studies , Isotope labeling experiments . Proficient with chemical databases such as SciFinder , Reaxys , and softwares such as ChemDraw , MNova , TopSpin , Origin , Mercury , EndNote . Email me at annapureddyraj gmail . com . Technologies : NMR
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Amgen Scholars Senior Program Leader . Review applications and select participants Host and implement programming events Lead face to face meetings with three mentees Lead a team of program leaders to design programming . I am a student at Stanford University pursuing a Ph.D. in Biophysics . I find intracellular pathogens and how they interact with host metabolism very interesting . My other interests include life science venture creation , consulting , and patenting . Twitter : techmobio . Technologies :
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Bioinformatics Scientist and Team Lead . . Experienced bioinformatics scientist with training in both dry lab and wet lab . Practical experience in protocols to generate sequencing data , applied statistics to design analysis pipelines , and web development tools to visualize results . In depth knowledge in ontologies and protein function prediction , as well as sequence analysis from multiple platforms and different types of experiments . Natural problem solving skills , and careful attention to details with creative and collaborative personality . . Technologies :
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Research Computing Analyst III . . . Technologies :
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Postgraduate Fellow . Postgraduate fellowship in Francesca Coscia 's Lab https : humantechnopole.it en research groups coscia group applying biochemistry , biophysics and cryo EM to study thyroid biology . . . Technologies : CryoEM
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proteins;characterization;structure
|
Research Associate . . Khamal Kwesi Ampah holds a position as a Graduate Teaching Assistant in the University of Sheffield Biomedical Science Department . He is a PhD student in the same department and expected to graduate on 01 10 2016 . He has trained and supervised approximately 400 undergraduate students in basic laboratory techniques , cell and molecular biology . Khamal s experiences range from cell culturing , molecular cloning technique , signal transduction research Co Immunoprecitation and Western blot , immunofluorescence microscopy , protein purification , mass spectrometry to microbiological assays . Khamal is a team player . He was a member of immuno oncology team that developed an oral mucosal cancer vaccine business plan during a one week innovation summer camp organized by Merck Serono Biopharmaceutical Company , Darmstadt , Germany in July , 2014 . In addition , together with a team of five researchers , we presented a business plan on drug discovery with our hypothetical company named INNEUROTOX with a mission to target chronic inflammatory pain and transform lives through the discovery and commercialization of novel safer painkillers . Khamal is innovative , passionate , trustworthy , hard worker and has received several scholarships . He is a recipient of a three year University of Sheffield Prize Award with annual stipend of 16000 and free tuition fee . His current research focuses on the role of SNARE proteins in post Golgi trafficking and their relevance in antibody production . He also received a four year Ghana and China government scholarship to study Mandarin and MSc . Cell Biology in China , where his project focused on the molecular mechanisms underlying cancer cells migration . He is willing to relocate and has experienced different cultures . Khamal is self driven and productive . He is a co author of six peer review papers . He has given several talks and poster presentations . Khamal has interest in developing therapeutic drugs against cancer . Technologies :
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Vice President , Research . I have the privilege to lead 80 of the best scientists to maximize the benefit people can get from the human genome . Our participant centric genetics research program drives : Target identification and validation to feed our therapeutic development program Our research collaborations with academia and industry R D for our consumer health and ancestry products We strive to do the best science , with the consumer at the heart of everything we do . . Experienced leader who loves science , scientists , and sharing science with colleagues , collaborators , and consumers . Specialties : genomics , genetics , scientific communication , product development , research regulations , data privacy .. Technologies :
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Marie Sk odowska Curie Individual Fellow . . Experienced researcher with a track record of quantitative interdisciplinary work at the crossroads of physics , biology , applied mathematics and social science . Proficient in bringing together diverse computational and experimental methodologies to tackle complex problems . Skilled in agent based and individual based mathematical modeling , analysis of large multidimensional datasets , image processing , machine vision , natural language processing , network analysis , social media api . Current areas of interest include data science and big data , risk assesment , city analytics , remote sensing , computational social science , mathematical and computational biology .. Technologies :
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Salk Fellow Principal Investigator . . . Technologies :
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PhD Graduate . Laboratory : Cibles Th rapeutiques et Conc ption de M dicaments CiTCoM Therapeutic Targets and Drug Design Eng Universit Paris Cit ex Paris Descartes Description : Development of an integrative molecular modeling solution to predict biomolecules 3D structures with significant implication for drug discovery field . The strategy aims to steer model to its target structure along a molecular modeling simulation implementing experimental structural data SAXS intensity . Domain : Molecular Modeling , Structural Computational Biology and Bioinformatics Hard Skills : Python , Fortran 90 , Bash Linux shell , LaTeX High Performance Computing Optimization of force field parameters Structural experimental data treatment : SAXS , X Ray Crystallography , NMR , Cryo EM , Chemical probing SHAPE Method of simulation : All Atom and Coarse Grained Molecular Dynamics Implicit and Explicit Solvant Enhanced Sampling Techniques : Temperature Replica Exchange Molecular Dynamics T REMD Normal Mode Analysis NMA Soft Skills : Communication and Vulgarization of highly technical topics Working with multidisciplinary teams . I am passionate about how fast artificial intelligence is taking root in the pharmaceutical industries and medical fields . More than ready and motivated to take up the challenge of applying such innovative approaches to drug discovery and development . Relying on my versatile profile from molecular modeler , structural biologist and biochemist perspectives , I have developed adaptability skills to resolve cross functional issues . I have demonstrated strong verbal communication skills through participation to congresses , teaching and supervising missions .. Technologies : Xray;CryoEM;NMR
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Computational Biologist Principal Scientist . I work in a preclinical optical microscopy team focusing on image analysis workflows supporting drug discovery programs . This is part of the Lab Operations team , which broadly supports the Neuroscience Pain Research Unit programs across all disease areas of interest . The primary goal is to enable project teams to accurately and efficiently quantitate pre clinical microscopy data to drive robust decisions around target mechanisms and validation , compound effects , biomarkers and assay development . I work within a large matrix environment , collaborating across multiple groups including discovery biology , preclinical imaging , research statistics , and informatics . In this role , I analyze experiments employing various optical microscopy and video imaging modalities . Additionally , I implement and apply innovative image analysis methods and develop algorithms to analyze complex , multi dimensional images to help drive data driven drug discovery and development decisions . . . Technologies :
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Doctoral Candidate . . My name is Nate Burman . I am a graduate of Carroll College with a degree in Molecular Biology Biochemsitry and a Chemistry minor . I received my Masters of Science from Montana State University and I am currently pursuing a Ph.D. focused on biochemistry structural biology in Blake Wiedenheft 's Lab . My current work is centered on using combined Cryo Electron Tomography and Single Particle Analysis to develop visual proteomics models of macromolecular complexes within whole cells .. Technologies : CryoEM
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proteins;structure
|
Transition Lead for Computational Biology Core . Managing the transition from the London Research Institute to the Francis Crick Institute for the Bioinformatics and Biostatistics Facility . . Technologies :
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Senior Bioinformatics Scientist . Developing bioinformatics algorithms for molecular diagnostics , specifically biomarker assay and platform development , that leverage genomic and cell free DNA , in the domains of oncology , and organ health . . Bioinformatics Scientist working on problems in precision medicine leveraging genomics and transcriptomics , in the domains of oncology and organ transplant . Prior experience includes working in evolutionary bioinformatics , proteomics , systems biology , biophysics , graph theory , applied machine learning , deep learning , and quantum computing .. Technologies :
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Graduate Student . . Currently plunging into Cryo EM ; . Technologies : CryoEM
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structure
|
Research Director with the National Fund for Scientific Research . . Erik Goormaghtigh received a master degree and a PhD in chemistry from the Universit Libre de Bruxelles . After a two year post doc at UNC Chapel Hill , North Carolina , dedicated to the study of an ATPase , he received a position with the National Fund for Scientific Research , Belgium . He is now Research Director with this institution and Professor at the Universit Libre de Bruxelles . Since the late eighties , he developed infrared spectroscopy for the study of membrane proteins and lipids . Protein structure , orientation of secondary structure elements in the membrane and dynamics through H D exchange kinetics have been extensively investigated by infrared spectroscopy with the goal of understanding the minute conformational modifications that are responsible for transport activities . More recently , FTIR tools and FTIR imaging were developed in his laboratory for cell typing in cancers , antitumor drug modes of action and cell type sub type identification on cancer histological sections . He is the author of about 170 publications mostly related to infrared spectroscopy of biological membranes , proteins , cells and tissues . Technologies :
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membrane proteins;proteins;structure
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Scientist 2 . VAE , CNN , Cryo EM , Data analysis using pandas . . Technologies : CryoEM
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Director . 2022 present : Director , Biology Lead Protein Aggregation , Folding Clearance , H. Lundbeck A S Responsible for the scientific strategy within the Biology area Strategic support to Research Project leads and Biology Leads in linking biology to indication Secure knowledge transfer between projects within the area Represent projects within the area at upper management meetings Key driver for Business Development interactions within the area Evaluation of external research projects company assets Establishment and maintenance of external scientific collaborations Key contact person for scientific questions relating to the area As member for Next wave Forum in Lundbeck Research select and recommend explorative research activities and define critical path towards becoming a drug discovery project Daily scientific and people management of 2 Principal scientist , 1 technician , co supervision of PhD students . Twenty seven years experience in Drug Discovery within the Pharmaceutical Industry . Preclinical Research support to the development of new potential treatments of diseases in the central nervous system , in particular the Neurodegenerative diseases , Parkinson s disease and Alzheimer s disease . Extensive knowledge on the full value chain in Drug Discovery from Research to Marketing through work in Lundbeck s overall Strategy Team for Parkinson s disease and participation in cross functional talent groups . Nine years 1999 2008 experience in direct project management of multinational , cross functional research projects from target finding validation in vitro and in vivo to identification of a small molecule ready for clinical trials . Fifth teen years of experience , as head of department , in scientific and people management department sizes from 20 40 people . Current group from 2022 consist of 2 senior scientists , 1 technician , 3 associated PhD students . Five projects delivered to clinical development during this period . Management of external scientific collaborations with academic groups typically 10 15 collaborations . Twelve years experience in evaluating external assets 35 40 per year in collaboration with Business development Hands on experience in establishing cell based assays with disease relevant phenotypes endpoints and using these for target finding , target validation and profiling of efficacy of new potential drug candidates . Portfolio management . Chaired the Parkinson s Disease Team in Lundbeck Research for 5 years 2006 2010 . Therapeutic Biology Lead for Parkinson s Disease 2018 2020 . Main responsibility was to translate company strategy into specific research activities within Parkinson s disease and manage the activities during the early phases of drug discovery . Member of the Next wave Forum in Lundbeck Research 2018 overseeing early research activities and defining critical path towards becoming a drug discovery project . Research representative in the corporate Idea Fair 2019 2021 collecting ideas across the company on all aspects of improving company business . Biology Area Lead ; Protein Aggregation , Folding Clearance 2022 being responsible for strategic support to Research Project leads and Biology Leads in linking biology to indication . Strong external engagement in work facilitating commercialization of research at universities and increasing collaborations between academia and industry University of Aalborg , DK ; University of Aarhus , DK ; University of Lund , S ; MJ Fox Foundation , US . Technologies :
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idps;small molecules;stability
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Scientist II . . I am an independent thinker , tinkerer , and astute observer . My research helps uncover quantitative physical principles of 4D genome folding and its relation to life and disease . I communicate and collaborate effectively with leading scientists in diverse fields spanning from embryology to microbiology . My key expertise includes the development of 3D genomics pipelines , super resolution imaging and data analysis , and modeling of polymer dynamics .. Technologies :
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Professor of Bioinformatics . . Development of novel computational tools for the prediction of protein structures , functions and interactions from amino acid sequences . See : http : www.reading.ac.uk bioinf Prediction and experimental verification of the effects of mutations on protein folding and function Application of computational methods for understanding the molecular mechanisms of cardiovascular function and disease Development of algorithms for the evaluation of the quality of 3D models of proteins and setting data standards for theoretical model validation High performance computing for the large scale structure and functional annotation of the proteomes of organisms relevant to food security Participation in the biennial experiments for the Critical Assessment of Techniques for Protein Structure Prediction CASP Funding from BBSRC , MRC , Diamond Light Source , RCUK , International Governments . Technologies :
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Research Scientist . . Ten years experience in expression and purification of membrane proteins for functional and structural studies . Developed target specific strategies for protein expression , affinity purification and reconstitution of proteins into artificial lipid environments . Trained in time resolved optical spectroscopy and fluorescence spectroscopy methods , as well as in standard biochemical and molecular biology approaches , including genetic manipulations in bacteria and yeast . Experienced in experimental design , problem solving , data analysis , and science communication . . Technologies :
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membrane proteins;characterization;expression
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Scientist II Gene Therapy , Payload Engineering . . Passionate scientist with strong quantitative background and 6 years of experience in cell biology , genetic engineering , and biotechnology . Rigorous , results oriented , and hypothesis driven problem solver . Dedicated mentor and team player . Strong presentation skills . Fluent in English and German .. Technologies :
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Research Biochemist . First author PDB depositions : 6GRL , 6HH7 and 6HH8 6HZN . These PDB files will be cited in 2 of my first author upcoming publications .. Published first author article using SAXS and Cryo EM . . I am educated to PhD level combining 9 years of research experience in biochemistry with teaching and research supervision , having long standing interest in drug discovery process . Through my professional experience I have accumulated considerable experience in protein expression purification structural studies through the field of biochemistry , taking responsibility to maintain instrument , do research with own initiative . I consider myself creative for problem solving and enjoy taking responsibilities . As a person I am highly motivated to play a great role in healthcare industry utilizing my aspiration and experience . Keywords : PCR , Primer design , Cloning , Protein Purification , Affinity Chromatography , Size Exclusion Chromatography , Protein Crystallization , Differential Scanning Fluorimetry , Dynamic Light Scattering , Lipidic Cubic Phase Crystallization , Crystal Growth Optimization , Crystal fishing and freezing , Crystal native and anomalous data collection , Crystal data processing , Crystal structure solving , Crystal structure refinement , Small Angle X ray Scattering , . Technologies : Xray;CryoEM;SLS DLS;DSF
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proteins;characterization;expression;structure
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Senior Outsurcing Manager . . Fifteen years of R D experience in the pharmaceutical and biotech industry with a sound understanding of the pharmaceutical value chain Sound managerial and leadership experience with interdisciplinary and multicultural teams in local and global settings resulting in numerous successful drug discovery projects as well as technology and outsourcing collaborations Profound expertise in medicinal chemistry of small molecules , peptides , and enabling technologies with a track record of multiple drug candidates which entered into pre clinical and clinical development o Biological target classes : GPCR receptors , transporters , ion channels and enzymes o Therapeutic areas : neurological , psychiatric , and cardio metabolic diseases Enjoy managing and optimising organisational and disciplinary interfaces including science business , research development , chemistry biology , and between entities to enhance value creation Support innovation culture and LEAN thinking . Technologies :
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membrane proteins;peptides;small molecules;interaction
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Bioinformatics Scientist . . . Technologies :
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Chief Technician . Supervisor of Life Science Soft Materials area . I received my master 's degree in natural science followed by a PhD in animal biology at the University of Milano Italy where I received my formation in electron microscopy . After a research period at Rutgers University in Camden , New Jersey USA I received in 2011 my second master s degree in molecular biology at the university of Pavia Italy . In 2010 I moved at the Istituto Italiano di Tecnologia IIT in Genoa , where since 2017 I am part of the staff of the Electron Microscopy Facility . During these years I deepened my knowledge on the electron microscope itself focusing my interest on data collection and data analysis with particular emphasis on cryo electron microscopy and cryo processing methods . In these fields I am author of over 80 publications in international scientific journals with a h index of 23 source : Web of Science .. Technologies : CryoEM
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structure
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. . Structural biologist working in drug discovery , studying the atomic structures of integral membrane proteins using cryo electron microscopy and X ray crystallography . Technologies : Xray;CryoEM
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membrane proteins;structure
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Senior Research Scientist , Medicinal Chemistry . . HIGHLIGHTS Contributed to the drug discovery projects from lead identification through lead optimization in Oncology Kinases , Microtubule Targeting Agents , Antifolates , and PROTACs . Medicinal chemist with a strong background in the execution of multi step 15 organic synthesis . Proficient in catalytic , organometallic chemistry , peptide coupling , regioselective , ring formation reactions . Experienced in structure based drug design and ligand based drug design . Expert in chromatographic techniques , NMR , HPLC , and LC MS . Expert in computational programs such as Schrodinger Drug Discovery Suite Maestro , Glide , MacroModel , Prime , etc . , Chemical Computing Group MOE , Spartan , Discovery Studio , Sybyl , PyMOL , ACD Labs , ChemDraw , Chem3D , etc . Expert in ELN , Chromeleon , Advion , Topspin , CMC assist , MestreNova , MestRe C , Scifinder , Endnote , etc . Proficient in the analysis , interpretation , and visualization of the results of small molecule drug discovery projects . I enjoy working as part of a team to solve complex scientific problems that contribute to improving human health . My doctoral research was focused on the design and synthesis of microtubule targeting agents MTAs , Receptor Tyrosine Kinase inhibitors , Antifolates , and PROTACs for cancer .. Technologies : NMR
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molecular glues;interaction;screening;stability
|
Bioinformatics Consultant . . Multidisciplinary researcher and data analyst with a focus on extracting knowledge from even the noisiest , heterogeneous biological data via inferential statistics , Bayesian statistics and machine learning . Effective communicator and coordinator , verbally and graphically relaying results to collaborators from both technical and non technical backgrounds and guiding complex projects to completion . Experienced software developer , comfortably using Python , R , and C , along with standard Unix tools to develop efficient analysis pipelines . Strong commitment to good software engineering and data management principles .. Technologies :
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Vice President , Molecular Sciences . . . Technologies : Xray;DSC
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Senior Scientist . . Structural biologist interested in using cryo EM and X ray crystallography to accelerate the drug discovery process . Experienced in deciphering the structure and function relationship of macromolecules that are associated with human dieseases .. Technologies : Xray;CryoEM
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proteins;structure
|
Senior Bioinformatics Scientist . . Researcher applying machine learning and data visualization techniques to high throughput sequencing data to answer questions across a range of biological fields . Broad interests and a passion for thinking deeply about data to learn domain knowledge . Biological experience includes : metagenomics , immunology , virology , marine biology , infectious diseases , developmental biology , microbiomes , and stem cell biology . Other interests include : quantum information and computational linguistics .. Technologies :
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Ontology Informatics Consultant . Provision of ontology , information architecture informatics services within the Life Sciences . . Experienced consultant with a demonstrated history of working on software and informatics projects in the life sciences . Skilled in Technical Writing , Technical Project Management , Data Architecture and modelling UML , XML , XSD and JSON schema , Ontologies and other semantic technologies RDF , OWL , SPARQL . Deep experience in metadata management and cataloguing . Research and development professional with a PhD focused in Computational Biology protein structure analysis from University of Leeds . . Technologies :
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R D Support Scientist . Coordinating and performing product and process improvement efforts and sustaining activities for CMS R D Cascadion assay system . . Experienced research scientist in the field of biochemisty and biotechnology , special knowledge in glycobiology . Versatile experience in hands on laboratory work as well as scientific research planning , project work and documentation . Knowledge in glycan and protein , especially antibody analytics , glycoengineering and protein expression . Specialties : Glycans , antibodies , chromatography and HPLC , mass spectrometry . Technologies :
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antibodies;developing;expression
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Postdoctoral Associate . . I am a biochemist seeking to better understand how solute carrier SLC transporters , the second largest membrane protein families and emerging therapeutic targets , mediate metabolic flux and maintain cellular homeostasis . My expertise includes multiple biochemistry and structural biology methodologies . Experienced working with nematode C.elegans and mammalian cell culture .. Technologies :
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membrane proteins;structure
|
Computer Scientist in Genomics . Currently studying the Huntington HTT gene repeat instability using the 100,000 Genomes Project database . . Interested in everything to do with the brain and genomics . . Technologies :
| null |
Research Fellow . . . Technologies :
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Staff Scientist . Department of Cellular Logistics . I 'm a biochemist and structural biologist with experience in membrane protein biochemistry , cryo electron microscopy and X ray crystallography . My research focuses on the mechanisms of protein transport across membranes .. Technologies : Xray;CryoEM
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membrane proteins;structure
|
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