instruction stringlengths 223 1.46k | input stringlengths 68 1.85k | response stringlengths 3 12 |
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<Instruct>: Given the context 'Naloxone reverses the antihypertensive effect of clonidine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine]
<Options>: A: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
B: clonidine hydrochloride (aka clonidine)
C: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
D: clonixin
E: allylnormorphine (aka nalorphine)
F: naloxone methiodide (aka n-methylnaloxone)
G: naloxone, buprenorphine (aka buprenorphine, naloxone drug combination)
H: clonidine para-isothiocyanate (aka clonidine 4-isothiocyanate)
I: n-allylnoretorphine (aka alletorphine)
J: naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-isomer (aka naloxone)
K: None of the above. | [J; B] |
<Instruct>: Given the context 'Naloxone reverses the antihypertensive effect of clonidine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine]
<Options>: A: clont (aka metronidazole)
B: naloxon curamed (aka naloxone)
C: clonixin
D: clonidine monohydrochloride (aka clonidine)
E: naloxone, buprenorphine (aka buprenorphine, naloxone drug combination)
F: clonidine para-isothiocyanate (aka clonidine 4-isothiocyanate)
G: n-allylnoretorphine (aka alletorphine)
H: nalorphine epoxide (aka nalorphine-7,8-oxide)
I: clonidine - chlorthalidone - drug combination (aka clonidine, chlorthalidone drug combination)
J: naloxone methiodide (aka n-methylnaloxone)
K: None of the above. | [B; D] |
<Instruct>: Given the context 'In unanesthetized, spontaneously hypertensive rats the decrease in blood pressure and heart rate produced by intravenous clonidine, 5 to 20 micrograms/kg, was inhibited or reversed by nalozone, 0.2 to 2 mg/kg.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clonidine]
<Options>: A: clonitralide (aka niclosamide)
B: clonidine - chlorthalidone - drug combination (aka clonidine, chlorthalidone drug combination)
C: clds (aka clonidine-displacing substance)
D: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
E: clonidine hydrochloride (aka clonidine)
F: None of the above. | [E] |
<Instruct>: Given the context 'The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [alpha-methyldopa; naloxone]
<Options>: A: naled
B: n-allylnoretorphine (aka alletorphine)
C: allylnormorphine (aka nalorphine)
D: naloxone hydrochloride, (5 beta,9 alpha,13 alpha,14 alpha)-isomer (aka naloxone)
E: methyldopamine (aka deoxyepinephrine)
F: naltrexone
G: apo methyldopa (aka methyldopa)
H: 3-methoxydopa (aka 3-methoxytyrosine)
I: alpha-methyldopamine, (s)-isomer (aka alpha-methyldopamine)
J: 3-o-methylmethyldopa
K: None of the above. | [G; D] |
<Instruct>: Given the context 'The hypotensive effect of 100 mg/kg alpha-methyldopa was also partially reversed by naloxone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [alpha-methyldopa; naloxone]
<Options>: A: nalorphine epoxide (aka nalorphine-7,8-oxide)
B: naloxone, buprenorphine (aka buprenorphine, naloxone drug combination)
C: methyldopamine (aka deoxyepinephrine)
D: methyldopa
E: 3-o-methylmethyldopa
F: curamed, naloxon (aka naloxone)
G: 3-o-methyl-alpha-methyldopamine
H: naltrexone
I: naled
J: alpha-methyldopamine, (s)-isomer (aka alpha-methyldopamine)
K: None of the above. | [D; F] |
<Instruct>: Given the context 'Naloxone alone did not affect either blood pressure or heart rate.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone]
<Options>: A: nalorphine
B: nalorphine epoxide (aka nalorphine-7,8-oxide)
C: n-allylnoretorphine (aka alletorphine)
D: naltrexone
E: dihydride, naloxone hydrochloride (aka naloxone)
F: None of the above. | [E] |
<Instruct>: Given the context 'Naloxone alone did not affect either blood pressure or heart rate.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone]
<Options>: A: n-allylnoretorphine (aka alletorphine)
B: nalorphine epoxide (aka nalorphine-7,8-oxide)
C: nalorphine
D: naltrexone
E: None of the above. | [E] |
<Instruct>: Given the context 'In brain membranes from spontaneously hypertensive rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding of [3H]-naloxone (8 nM), and naloxone, 10(-8) to 10(-4) M, did not influence clonidine-suppressible binding of [3H]-dihydroergocryptine (1 nM).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clonidine; naloxone]
<Options>: A: naled
B: clonidine-displacing substance
C: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
D: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
E: n-allylnoretorphine (aka alletorphine)
F: dihydrochloride, clonidine (aka clonidine)
G: clonidine, chlorthalidone drug combination
H: naloxone hydrochloride (aka naloxone)
I: nalorphine epoxide (aka nalorphine-7,8-oxide)
J: buprenorphine naloxone (aka buprenorphine, naloxone drug combination)
K: None of the above. | [F; H] |
<Instruct>: Given the context 'In brain membranes from spontaneously hypertensive rats clonidine, 10(-8) to 10(-5) M, did not influence stereoselective binding of [3H]-naloxone (8 nM), and naloxone, 10(-8) to 10(-4) M, did not influence clonidine-suppressible binding of [3H]-dihydroergocryptine (1 nM).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clonidine; naloxone]
<Options>: A: buprenorphine naloxone (aka buprenorphine, naloxone drug combination)
B: naled
C: clds (aka clonidine-displacing substance)
D: naloxone methiodide (aka n-methylnaloxone)
E: n-allylnoretorphine (aka alletorphine)
F: clonidine - chlorthalidone - drug combination (aka clonidine, chlorthalidone drug combination)
G: hydrochloride, naloxone (aka naloxone)
H: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
I: clonitralide (aka niclosamide)
J: monohydrochloride, clonidine (aka clonidine)
K: None of the above. | [J; G] |
<Instruct>: Given the context 'As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or alpha-methyldopa and the possible role of the opiate in the central control of sympathetic tone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine; alpha-methyldopa]
<Options>: A: nalorphine epoxide (aka nalorphine-7,8-oxide)
B: alpha-methyldopamine, (r)-isomer (aka alpha-methyldopamine)
C: n-allylnoretorphine (aka alletorphine)
D: 3-o-methyl-alpha-methyldopamine, (+-)-isomer (aka 3-o-methyl-alpha-methyldopamine)
E: clonixin
F: buprenorphine naloxone (aka buprenorphine, naloxone drug combination)
G: methyldopamine (aka deoxyepinephrine)
H: alpha-methyldopa (aka methyldopa)
I: nalorphine
J: 3-o-methylmethyldopa
K: nitroclofene
L: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
M: hydrochloride, naloxone (aka naloxone)
N: clonidine para-isothiocyanate (aka clonidine 4-isothiocyanate)
O: clonidine
P: None of the above. | [M; O; H] |
<Instruct>: Given the context 'As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or alpha-methyldopa and the possible role of the opiate in the central control of sympathetic tone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine; alpha-methyldopa]
<Options>: A: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
B: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
C: monohydrochloride, clonidine (aka clonidine)
D: alpha-methyldopamine
E: methyldopa
F: naloxone hydrochloride (aka naloxone)
G: n-allylnoretorphine (aka alletorphine)
H: nitroclofene
I: 3-o-methyl-alpha-methyldopamine
J: methyldopamine (aka deoxyepinephrine)
K: clonidine para-isothiocyanate (aka clonidine 4-isothiocyanate)
L: nalorphine epoxide (aka nalorphine-7,8-oxide)
M: 3-o-methyldopa (aka 3-methoxytyrosine)
N: naltrexone
O: naloxone methiodide (aka n-methylnaloxone)
P: None of the above. | [F; C; E] |
<Instruct>: Given the context 'As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or alpha-methyldopa and the possible role of the opiate in the central control of sympathetic tone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine; alpha-methyldopa]
<Options>: A: 3-o-methyl-alpha-methyldopamine
B: nitroclofene
C: methyldopa
D: alpha-methyldopamine
E: monohydrochloride, clonidine (aka clonidine)
F: methyldopamine (aka deoxyepinephrine)
G: naltrexone
H: nalorphine epoxide (aka nalorphine-7,8-oxide)
I: naloxone methiodide (aka n-methylnaloxone)
J: 3-o-methyldopa (aka 3-methoxytyrosine)
K: clonidine para-isothiocyanate (aka clonidine 4-isothiocyanate)
L: n-allylnoretorphine (aka alletorphine)
M: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
N: (4-chlorophenyl)-(1h-imidazol-4-ylmethyl)-isopropyl-amine
O: None of the above. | [O; E; C] |
<Instruct>: Given the context 'As naloxone and clonidine do not appear to interact with the same receptor site, the observed functional antagonism suggests the release of an endogenous opiate by clonidine or alpha-methyldopa and the possible role of the opiate in the central control of sympathetic tone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [naloxone; clonidine; alpha-methyldopa]
<Options>: A: n-allylnoretorphine (aka alletorphine)
B: clonixin
C: 3-o-methyl-methyldopa (aka 3-o-methylmethyldopa)
D: naltrexone
E: nalorphine
F: alpha methyldopa (aka methyldopa)
G: hydrochloride, clonidine (aka clonidine)
H: hydrochloride, naloxone (aka naloxone)
I: alpha-methyldopamine, (+-)-isomer (aka alpha-methyldopamine)
J: 3-o-methyl-alpha-methyldopamine, (+-)-isomer (aka 3-o-methyl-alpha-methyldopamine)
K: clonitralide (aka niclosamide)
L: clonidine-displacing substance
M: 3-methoxydopa (aka 3-methoxytyrosine)
N: buprenorphine naloxone (aka buprenorphine, naloxone drug combination)
O: chlornitrofen (aka 2,4,6-trichlorophenyl 4-nitrophenyl ether)
P: None of the above. | [H; G; F] |
<Instruct>: Given the context 'Lidocaine-induced cardiac asystole.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lidocaine]
<Options>: A: methyl-lidocaine (aka n-methyllidocaine)
B: 2-(diethylamino)-n-(2,6-dimethylphenyl)acetamide (aka lidocaine)
C: lidemol (aka fluocinonide)
D: n-(beta-phenylethyl)lidocaine (aka tonicaine)
E: leocaine
F: None of the above. | [B] |
<Instruct>: Given the context 'Intravenous administration of a single 50-mg bolus of lidocaine in a 67-year-old man resulted in profound depression of the activity of the sinoatrial and atrioventricular nodal pacemakers.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lidocaine]
<Options>: A: lidol (aka meperidine)
B: 2-chloro-n-(2,6-diethylphenyl)acetamide
C: 2-2etn-2mephacn (aka lidocaine)
D: acetamide, 2-(diethylamino)-n-(2,4,6-trimethylphenyl)- (aka trimecaine)
E: n-(beta-phenylethyl)lidocaine (aka tonicaine)
F: None of the above. | [C] |
<Instruct>: Given the context 'The patient had no apparent associated conditions which might have predisposed him to the development of bradyarrhythmias; and, thus, this probably represented a true idiosyncrasy to lidocaine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lidocaine]
<Options>: A: lidol (aka meperidine)
B: acetamide, 2-(diethylamino)-n-(2,4,6-trimethylphenyl)- (aka trimecaine)
C: lidocaine monoacetate (aka lidocaine)
D: methyl-lidocaine (aka n-methyllidocaine)
E: leocaine
F: None of the above. | [C] |
<Instruct>: Given the context 'Suxamethonium infusion rate and observed fasciculations.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [suxamethonium]
<Options>: A: chloride, methylmethioninesulfonium (aka vitamin u)
B: sulfometuron methyl
C: suxethonium
D: suxibuzone
E: bromide, suxamethonium (aka succinylcholine)
F: None of the above. | [E] |
<Instruct>: Given the context 'Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [suxamethonium chloride; sch]
<Options>: A: sch.036 (aka sch 036)
B: scholzite
C: schottenol (aka stigmast-7-enol)
D: methylmethionine sulfonium chloride (aka vitamin u)
E: schisandrene
F: sch-a compound
G: succinylcholine chloride (aka succinylcholine)
H: methionylmethylsulfonium chloride
I: trimethylselenonium chloride (aka trimethylselenonium)
J: trimethylsulfonium chloride (aka trimethylsulfonium)
K: None of the above. | [G; G] |
<Instruct>: Given the context 'Suxamethonium chloride (Sch) was administered i.v. to 36 adult males at six rates: 0.25 mg s-1 to 20 mg s-1.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [suxamethonium chloride; sch]
<Options>: A: schmitterite
B: sch6
C: schoenoside
D: suxethonium
E: methionylmethylsulfonium chloride
F: methylsulfonium chloride, methionine (aka vitamin u)
G: trimethylselenonium chloride (aka trimethylselenonium)
H: bromide, suxamethonium (aka succinylcholine)
I: schoberine
J: schisandrene
K: None of the above. | [H; H] |
<Instruct>: Given the context 'The infusion was discontinued either when there was no muscular response to tetanic stimulation of the ulnar nerve or when Sch 120 mg was exceeded.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sch]
<Options>: A: schisanartane
B: sch-p (aka stilbazochrome-p)
C: schmitterite
D: scholzite
E: schinol (aka masticadienolic acid)
F: None of the above. | [F] |
<Instruct>: Given the context 'Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: scopadulin
B: scopoletin
C: methobromide, hyoscine (aka n-methylscopolamine)
D: hyoscine n butylbromide (aka butylscopolammonium bromide)
E: scopolamines (aka scopolamine derivatives)
F: epimeloscine (aka meloscine)
G: galanthamine (aka galantamine)
H: hyoscine (aka scopolamine)
I: galanthamine type amaryllidaceae alkaloids (aka amaryllidaceae alkaloids)
J: benzylamine hydrobromide (aka benzylamine)
K: galanthaminone
L: 2-aminotetralin hydrobromide (aka 2-aminotetralin)
M: scopathricin
N: scopolamine methylbromide (aka n-methylscopolamine)
O: None of the above. | [G; H; H] |
<Instruct>: Given the context 'Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: aniline hydrobromide (aka aniline)
B: transderm scop (aka scopolamine)
C: n-butylbromide, hyoscine (aka butylscopolammonium bromide)
D: apogalanthamine
E: hyoscine n-oxide
F: epimeloscine (aka meloscine)
G: diaminoguanidine hydrobromide (aka diaminoguanidine)
H: scopolamines (aka scopolamine derivatives)
I: methiodide, hyoscine (aka n-methylscopolamine)
J: galanthamine hydrobromide (aka galantamine)
K: benzylamine hydrobromide (aka benzylamine)
L: diacetyl scopadol (aka diacetylscopadol)
M: scopadulin
N: scopathricin
O: None of the above. | [J; B; B] |
<Instruct>: Given the context 'Galanthamine hydrobromide, a longer acting anticholinesterase drug, in the treatment of the central effects of scopolamine (Hyoscine).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: scopadulin
B: scopolin
C: galanthaminone
D: hyoscine n-oxide
E: scopolamine
F: epimeloscine (aka meloscine)
G: adtn hydrobromide (aka adtn)
H: alentamol hydrobromide, (-)-isomer (aka alentamol)
I: scopolan (aka butylscopolammonium bromide)
J: methylbromide, scopolamine (aka n-methylscopolamine)
K: aniline hydrobromide (aka aniline)
L: diacetyl scopadol (aka diacetylscopadol)
M: galanthamine hydrobromide (aka galantamine)
N: scopolamines (aka scopolamine derivatives)
O: None of the above. | [M; E; E] |
<Instruct>: Given the context 'Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: scopolamine methylbromide (aka n-methylscopolamine)
B: apo-galanthamine (aka apogalanthamine)
C: galanthaminone
D: hyoscine (aka scopolamine)
E: diaminoguanidine hydrobromide (aka diaminoguanidine)
F: epimeloscine (aka meloscine)
G: galanthamine hydrobromide (aka galantamine)
H: scopadulin
I: hyoscine methiodide (aka n-methylscopolamine)
J: hyoscine n-oxide
K: scopolan (aka butylscopolammonium bromide)
L: adtn hydrobromide (aka adtn)
M: scopolamines (aka scopolamine derivatives)
N: hyoscine n-butylbromide (aka butylscopolammonium bromide)
O: None of the above. | [G; D; D] |
<Instruct>: Given the context 'Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: aniline hydrobromide (aka aniline)
B: scopolamine methylbromide (aka n-methylscopolamine)
C: scopolamines (aka scopolamine derivatives)
D: scopathricin
E: phenacylamine hydrobromide (aka phenacylamine)
F: galanthaminone
G: scopolamine cooper (aka scopolamine)
H: hyoscine methobromide (aka n-methylscopolamine)
I: glycine amide hydrobromide (aka glycine amide)
J: hyoscine n-butylbromide (aka butylscopolammonium bromide)
K: hyoscine n-oxide
L: galanthamine hydrobromide (aka galantamine)
M: epimeloscine (aka meloscine)
N: None of the above. | [L; G; G] |
<Instruct>: Given the context 'Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: nigeglanine hydrobromide (aka nigeglanine)
B: scopoletin
C: transderm scop (aka scopolamine)
D: phenacylamine hydrobromide (aka phenacylamine)
E: diacetyl scopadol (aka diacetylscopadol)
F: epimeloscine (aka meloscine)
G: methiodide, hyoscine (aka n-methylscopolamine)
H: scopolamines (aka scopolamine derivatives)
I: apogalanthamine
J: hyoscine n butylbromide (aka butylscopolammonium bromide)
K: hyoscine n-oxide
L: diaminoguanidine hydrobromide (aka diaminoguanidine)
M: methylbromide, scopolamine (aka n-methylscopolamine)
N: galanthamine (aka galantamine)
O: None of the above. | [N; C; C] |
<Instruct>: Given the context 'Galanthamine hydrobromide, an anticholinesterase drug capable of penetrating the blood-brain barrier, was used in a patient demonstrating central effects of scopolamine (hyoscine) overdosage.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [galanthamine hydrobromide; scopolamine; hyoscine]
<Options>: A: scopoletin
B: scopolamines (aka scopolamine derivatives)
C: apogalanthamine
D: nigeglanine hydrobromide (aka nigeglanine)
E: galanthamine (aka galantamine)
F: epimeloscine (aka meloscine)
G: diacetyl scopadol (aka diacetylscopadol)
H: diaminoguanidine hydrobromide (aka diaminoguanidine)
I: phenacylamine hydrobromide (aka phenacylamine)
J: methylbromide, scopolamine (aka n-methylscopolamine)
K: hyoscine n butylbromide (aka butylscopolammonium bromide)
L: hyoscine n-oxide
M: methiodide, hyoscine (aka n-methylscopolamine)
N: None of the above. | [E; N; N] |
<Instruct>: Given the context 'It is longer acting than physostigmine and is used in anaesthesia to reverse the non-depolarizing neuromuscular block.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [physostigmine]
<Options>: A: physostigmine heptyl
B: physostigmine
C: physalemin (aka physalaemin)
D: phosphostigmine (aka parathion)
E: pyridostigmine (aka pyridostigmine bromide)
F: None of the above. | [B] |
<Instruct>: Given the context 'However, studies into the dose necessary to combating scopolamine intoxication are indicated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [scopolamine]
<Options>: A: derivatives, scopolamine (aka scopolamine derivatives)
B: scopolin
C: diacetyl scopadol (aka diacetylscopadol)
D: hyoscine n-oxide
E: scopace (aka scopolamine)
F: None of the above. | [E] |
<Instruct>: Given the context 'Effects of uninephrectomy and high protein feeding on lithium-induced chronic renal failure in rats.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: lithium-9
B: compounds, lithium (aka lithium compounds)
C: liotrix (aka thyroxine, triiodothyronine drug combination)
D: lithium-7 (aka lithium)
E: lithium sulfide
F: None of the above. | [D] |
<Instruct>: Given the context 'Rats with lithium-induced nephropathy were subjected to high protein (HP) feeding, uninephrectomy (NX) or a combination of these, in an attempt to induce glomerular hyperfiltration and further progression of renal failure.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: lithium-9
B: lithium-7 (aka lithium)
C: liotrix (aka thyroxine, triiodothyronine drug combination)
D: lithium-4
E: lithium-11
F: None of the above. | [B] |
<Instruct>: Given the context 'Newborn female Wistar rats were fed a lithium-containing diet (50 mmol/kg) for 8 weeks and then randomized to normal diet, HP diet (40 vs. 19%), NX or HP+NX for another 8 weeks.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: lithium-9
B: lithium-7 (aka lithium)
C: lithium gaba (aka gamma-aminobutyric acid)
D: lithium citrate
E: lithium-4
F: None of the above. | [B] |
<Instruct>: Given the context 'Corresponding non-lithium pretreated groups were generated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: lithium-7 (aka lithium)
B: liotrix (aka thyroxine, triiodothyronine drug combination)
C: lithium-3
D: lithium gaba (aka gamma-aminobutyric acid)
E: lithium-4
F: None of the above. | [A] |
<Instruct>: Given the context 'When comparing all lithium treated versus non-lithium-treated groups, lithium caused a reduction in glomerular filtration rate (GFR) without significant changes in effective renal plasma flow (as determined by a marker secreted into the proximal tubules) or lithium clearance.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: chloride, lithium (aka lithium chloride)
B: lithium-11
C: lithium gluconate (aka gluconic acid)
D: lithium-9
E: lithium-7 (aka lithium)
F: None of the above. | [E] |
<Instruct>: Given the context 'Consequently, lithium pretreatment caused a fall in filtration fraction and an increase in fractional Li excretion.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium; li]
<Options>: A: liyan
B: lithium compounds
C: carbonate, lithium (aka lithium carbonate)
D: lithium-3
E: chloride, lithium (aka lithium chloride)
F: litreol (aka 3-(pentadec-10-enyl)catechol)
G: lithium gaba (aka gamma-aminobutyric acid)
H: lithium-7 (aka lithium)
I: None of the above. | [H; H] |
<Instruct>: Given the context 'Consequently, lithium pretreatment caused a fall in filtration fraction and an increase in fractional Li excretion.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium; li]
<Options>: A: liogen (aka fluphenazine depot)
B: lithium-9
C: liotrix (aka thyroxine, triiodothyronine drug combination)
D: lithium-3
E: lithium sulfide
F: lithium-4
G: carbonate, lithium (aka lithium carbonate)
H: lithium
I: None of the above. | [H; H] |
<Instruct>: Given the context 'Lithium also caused proteinuria and systolic hypertension in absence of glomerulosclerosis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [lithium]
<Options>: A: lithium 7 (aka lithium)
B: lithium-3
C: lithium gaba (aka gamma-aminobutyric acid)
D: compounds, lithium (aka lithium compounds)
E: lithium citrate
F: None of the above. | [A] |
<Instruct>: Given the context 'HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in lithium pretreated rats.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [creatinine; lithium]
<Options>: A: lithium compounds
B: lithium sulfide
C: citrinacetal
D: salt, creatinine sulfate (aka creatinine)
E: 5,7-dihydroxytryptamine creatinine
F: epoxycreatine
G: liotrix (aka thyroxine, triiodothyronine drug combination)
H: lithium-11
I: lithium-7 (aka lithium)
J: r(acc) (aka adenylyl-(3'-5')-cytidylyl-(3'-5')-cytidine)
K: None of the above. | [D; I] |
<Instruct>: Given the context 'HP failed to accentuante progression of renal failure and in fact tended to increase GFR and decrease plasma creatinine levels in lithium pretreated rats.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [creatinine; lithium]
<Options>: A: liotrix (aka thyroxine, triiodothyronine drug combination)
B: lithium
C: lithium-3
D: citrinacetal
E: creatine riboside (aka 2-(2-(3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl)-1-methylcarbamimidamido)acetic acid)
F: bicarbonate, lithium (aka lithium carbonate)
G: lithium chloride
H: 5,7-dihydroxytryptamine creatinine
I: creatinine sulfate salt (aka creatinine)
J: creatine
K: None of the above. | [I; B] |
<Instruct>: Given the context 'NX+HP caused a further rise in blood pressure in Li-pretreated rats.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [li]
<Options>: A: lithium-7 (aka lithium)
B: lithium-3
C: lithium-11
D: lithium-4
E: thallium
F: None of the above. | [A] |
<Instruct>: Given the context 'The results indicate that Li-induced nephropathy, even when the GFR is only modestly reduced, is associated with proteinuria and arterial systolic hypertension.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [li]
<Options>: A: thallium
B: lithium-7 (aka lithium)
C: liyan
D: liogen (aka fluphenazine depot)
E: li2s compound (aka lithium sulfide)
F: None of the above. | [B] |
<Instruct>: Given the context 'Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid; cyclosporin]
<Options>: A: cyclosporin h
B: fusicoccin
C: cyclosporin d
D: fusaricide
E: fusidic acid
F: cyclosporin f
G: cyclosporine
H: cyclosporin c
I: fumaric acid
J: fusicoccane a
K: None of the above. | [E; G] |
<Instruct>: Given the context 'Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid; cyclosporin]
<Options>: A: fumaric acid
B: cyclosporin c
C: cyclosporin d
D: fusicoccin
E: fusidic acid
F: fusicoccane a
G: fusaricide
H: cyclosporin f
I: cyclosporin h
J: None of the above. | [E; J] |
<Instruct>: Given the context 'Treatment of Crohn's disease with fusidic acid: an antibiotic with immunosuppressive properties similar to cyclosporin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid; cyclosporin]
<Options>: A: acid, fusidic (aka fusidic acid)
B: cyclosporine
C: fusicoccane a
D: cyclosporin c
E: fusicoccin-a (aka fusicoccin)
F: tricyclic cyclosporin a
G: acid, fusaric (aka fusaric acid)
H: fusaricidin a
I: cyclosporin a, 2-(o-(2-hydroxyethyl)-d-serine)- (aka sdz imm 125)
J: cyclosporin d
K: None of the above. | [A; B] |
<Instruct>: Given the context 'Fusidic acid is an antibiotic with T-cell specific immunosuppressive effects similar to those of cyclosporin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cyclosporin]
<Options>: A: cyclosporin f
B: cyclosporin g
C: cyclosporin-like substance
D: cyclosporin c
E: ciclosporin (aka cyclosporine)
F: None of the above. | [E] |
<Instruct>: Given the context 'Because of the need for the development of new treatments for Crohn's disease, a pilot study was undertaken to estimate the pharmacodynamics and tolerability of fusidic acid treatment in chronic active, therapy-resistant patients.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid]
<Options>: A: fusaricidin a
B: acid, fusidic (aka fusidic acid)
C: fusaricide
D: flavaspidic acid
E: fusaminic acid
F: None of the above. | [B] |
<Instruct>: Given the context 'Fusidic acid was administered orally in a dose of 500 mg t.d.s.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid]
<Options>: A: tetrahydrofuroic acid (aka tetrahydro-2-furancarboxylic acid)
B: fuscin
C: fusicoccane a
D: fusidic acid
E: fusaricidin a
F: None of the above. | [D] |
<Instruct>: Given the context 'Five of 8 patients (63%) improved during fusidic acid treatment: 3 at two weeks and 2 after four weeks.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid]
<Options>: A: fusicoccane a
B: piscidic acid
C: (s)-(+)-fusarinolic acid (aka fusarinolic acid)
D: fusicoccin
E: acid, fusidic (aka fusidic acid)
F: None of the above. | [E] |
<Instruct>: Given the context 'The results of this pilot study suggest that fusidic acid may be of benefit in selected chronic active Crohn's disease patients in whom conventional treatment is ineffective.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid]
<Options>: A: fusaricidin a
B: piscidic acid
C: fumaric acid
D: fuscine
E: fusidic acid, sodium salt (aka fusidic acid)
F: None of the above. | [E] |
<Instruct>: Given the context 'Because there seems to exist a scientific rationale for the use of fusidic acid at the cytokine level in inflammatory bowel disease, we suggest that the role of this treatment should be further investigated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [fusidic acid]
<Options>: A: flavaspidic acid
B: fusaricide
C: fusidin (aka fusidic acid)
D: tetrahydrofuroic acid (aka tetrahydro-2-furancarboxylic acid)
E: fusicoccin
F: None of the above. | [C] |
<Instruct>: Given the context 'Electrocardiographic evidence of myocardial injury in psychiatrically hospitalized cocaine abusers.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cocaine]
<Options>: A: carbocaïne (aka mepivacaine)
B: cocaine hcl (aka cocaine)
C: cathine (aka norpseudoephedrine)
D: coc compound (aka cholesteryl oleoyl carbonate)
E: cocaine methiodide
F: None of the above. | [B] |
<Instruct>: Given the context 'The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cocaine]
<Options>: A: cocobetaine
B: carbocaïne (aka mepivacaine)
C: cocaine
D: cocaine benzoyl thioester
E: carnitine
F: None of the above. | [C] |
<Instruct>: Given the context 'The electrocardiograms (ECG) of 99 cocaine-abusing patients were compared with the ECGs of 50 schizophrenic controls.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cocaine]
<Options>: A: cocobetaine
B: cocaine benzoyl thioester
C: carnitine
D: carbocaïne (aka mepivacaine)
E: None of the above. | [E] |
<Instruct>: Given the context 'Eleven of the cocaine abusers and none of the controls had ECG evidence of significant myocardial injury defined as myocardial infarction, ischemia, and bundle branch block.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cocaine]
<Options>: A: hcl, cocaine (aka cocaine)
B: crack cocaine
C: catecholamphetamine (aka alpha-methyldopamine)
D: cocaine benzoyl thioester
E: carnitine
F: None of the above. | [A] |
<Instruct>: Given the context 'Sulpiride-induced tardive dystonia.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride]
<Options>: A: sulpor (aka sulpiride)
B: sulperazon (aka sulperazone)
C: sulnate
D: suleparoid
E: 3-sulfonyl-1h-pyrrole
F: None of the above. | [A] |
<Instruct>: Given the context 'Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride; antidepressant]
<Options>: A: antidementia agent (aka nootropic agents)
B: suleparoid
C: atypical antidepressants (aka antidepressive agents, second-generation)
D: appetite depressant (aka appetite depressants)
E: antidepressant medication (aka antidepressive agents)
F: sulnate
G: sulpitil (aka sulpiride)
H: sultopride hydrochloride (aka amisulpride)
I: antipsychotic drug (aka antipsychotic agents)
J: sulpyrin (aka dipyrone)
K: None of the above. | [G; E] |
<Instruct>: Given the context 'Sulpiride is a selective D2-receptor antagonist with antipsychotic and antidepressant properties.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride; antidepressant]
<Options>: A: sulnate
B: sulperazone
C: sulproston (aka sulprostone)
D: antidepressive agents
E: sulprim (aka trimethoprim, sulfamethoxazole drug combination)
F: appetite-depressing drug (aka appetite depressants)
G: atypical antidepressants (aka antidepressive agents, second-generation)
H: antipsychotic drug (aka antipsychotic agents)
I: sulpitil (aka sulpiride)
J: antidementia agents (aka nootropic agents)
K: None of the above. | [I; D] |
<Instruct>: Given the context 'Although initially thought to be free of extrapyramidal side effects, sulpiride-induced tardive dyskinesia and parkinsonism have been reported occasionally.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride]
<Options>: A: sulnate
B: suleparoid
C: sulpor (aka sulpiride)
D: sulpyrin (aka dipyrone)
E: sulproston (aka sulprostone)
F: None of the above. | [C] |
<Instruct>: Given the context 'We studied a 37-year-old man who developed persistent segmental dystonia within 2 months after starting sulpiride therapy.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride]
<Options>: A: sulprim (aka trimethoprim, sulfamethoxazole drug combination)
B: sulnate
C: suleparoid
D: sultopride (aka amisulpride)
E: sulpitil (aka sulpiride)
F: None of the above. | [E] |
<Instruct>: Given the context 'We could not find any previous reports of sulpiride-induced tardive dystonia.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [sulpiride]
<Options>: A: 3-sulfonyl-1h-pyrrole
B: sulnate
C: sultopride hydrochloride (aka amisulpride)
D: suleparoid
E: sulp (aka sulpiride)
F: None of the above. | [E] |
<Instruct>: Given the context 'Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: aluminum-desferrioxamine complex (aka aluminoxamine)
B: desferrioxamine b mesylate (aka deferoxamine)
C: zinc-desferrioxamine
D: ferroxamine (aka ferrioxamine b)
E: cu(ii)-desferrioxamine (aka copper-desferal complex)
F: None of the above. | [B] |
<Instruct>: Given the context 'Ocular and auditory toxicity in hemodialyzed patients receiving desferrioxamine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: ferroxamine (aka ferrioxamine b)
B: aluminum-desferrioxamine complex (aka aluminoxamine)
C: zinc-desferrioxamine
D: cu(ii)-desferrioxamine (aka copper-desferal complex)
E: None of the above. | [E] |
<Instruct>: Given the context 'During an 18-month period of study 41 hemodialyzed patients receiving desferrioxamine (10-40 mg/kg BW/3 times weekly) for the first time were monitored for detection of audiovisual toxicity.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: desferrioxamine e
B: desferioximine (aka deferoxamine)
C: cu(ii)-desferrioxamine (aka copper-desferal complex)
D: manganese desferrioxamine (aka manganese desferioxamine)
E: desferriferrithiocin
F: None of the above. | [B] |
<Instruct>: Given the context 'Desferrioxamine withdrawal resulted in a complete recovery of visual function in 1 patient and partial recovery in 3, and a complete reversal of hearing loss in 3 patients and partial recovery in 3.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: cu(ii)-desferrioxamine (aka copper-desferal complex)
B: desferroxamine (aka deferoxamine)
C: deferrioxamine e
D: mangan-desferrioxamin
E: desferrioxamine e
F: None of the above. | [B] |
<Instruct>: Given the context 'This toxicity appeared in patients receiving the higher doses of desferrioxamine or coincided with the normalization of ferritin or aluminium serum levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: mangan-desferrioxamin
B: desferrioxamine e
C: n-hydroxy-desferrioxamine b (aka n-hydroxydesferrioxamine b)
D: mesylate, desferrioxamine b (aka deferoxamine)
E: cu(ii)-desferrioxamine (aka copper-desferal complex)
F: None of the above. | [D] |
<Instruct>: Given the context 'The data indicate that audiovisual toxicity is not an infrequent complication in hemodialyzed patients receiving desferrioxamine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [desferrioxamine]
<Options>: A: mesylate, desferrioxamine b (aka deferoxamine)
B: deferrioxamine e
C: aluminum-desferrioxamine complex (aka aluminoxamine)
D: manganese desferrioxamine (aka manganese desferioxamine)
E: desferrithiocin
F: None of the above. | [A] |
<Instruct>: Given the context 'Myasthenia gravis presenting as weakness after magnesium administration.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium nitrate
B: magnesium gluconate (aka gluconic acid)
C: compounds, magnesium (aka magnesium compounds)
D: magnesium
E: manganese
F: None of the above. | [D] |
<Instruct>: Given the context 'We studied a patient with no prior history of neuromuscular disease who became virtually quadriplegic after parenteral magnesium administration for preeclampsia.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium oxide
B: magmed (aka magaldrate)
C: magnesium-25
D: magnesium
E: magnesium-30
F: None of the above. | [D] |
<Instruct>: Given the context 'The serum magnesium concentration was 3.0 mEq/L, which is usually well tolerated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium
B: magnesium oxide
C: magnesium compounds
D: magnesium phosphate
E: mgcl2 (aka magnesium chloride)
F: None of the above. | [A] |
<Instruct>: Given the context 'The magnesium was stopped and she recovered over a few days.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium
B: magnesium-25
C: manganese
D: magnesium compounds
E: magnesium phosphate
F: None of the above. | [A] |
<Instruct>: Given the context 'Her acetylcholine receptor antibody level was markedly elevated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [acetylcholine]
<Options>: A: acetylcholine
B: acetyl carnitine (aka acetylcarnitine)
C: aminocholine
D: acetylethylcholine (aka acetylmonoethylcholine)
E: alpha-methylcholine
F: None of the above. | [A] |
<Instruct>: Given the context 'Although paralysis after magnesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only manifestation of the disease.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium-25
B: magnesium
C: aspartate, magnesium (aka aspartic acid)
D: magnesium bromide
E: magnesium nitrate
F: None of the above. | [B] |
<Instruct>: Given the context 'Although paralysis after magnesium administration has been described in patients with known myasthenia gravis, it has not previously been reported to be the initial or only manifestation of the disease.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium-25
B: aspartate, magnesium (aka aspartic acid)
C: magnesium bromide
D: magnesium nitrate
E: None of the above. | [E] |
<Instruct>: Given the context 'Patients who are unusually sensitive to the neuromuscular effects of magnesium should be suspected of having an underlying disorder of neuromuscular transmission.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [magnesium]
<Options>: A: magnesium-30
B: magnesium
C: magnesium-25
D: magnesium gluconate (aka gluconic acid)
E: aspartate, magnesium (aka aspartic acid)
F: None of the above. | [B] |
<Instruct>: Given the context 'Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; cyclophosphamide; ifosfamide]
<Options>: A: cyclophosphane (aka cyclophosphamide)
B: chloroacetaldehyde hydrate (aka chloroacetaldehyde)
C: 3-chlorolactaldehyde
D: iminocyclophosphamide (aka iminophosphamide)
E: 2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)tetrahydro-3-hydroxy-, 2-oxide (aka 3-hydroxycyclophosphamide)
F: 2-chloroacetal
G: beta-d-glucosyl-ifosfamide mustard (aka beta-d-glucosylisophosphoramide mustard)
H: chlorcyclamide
I: d4-cyclophosphamide
J: 3-chloro-anisaldehyde (aka 3-chloroanisaldehyde)
K: iso endoxan (aka ifosfamide)
L: fluoroacetaldehyde
M: cytosinine
N: 2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)-5,6-dihydro-, 2-oxide (aka iminophosphamide)
O: 2h-1,3,2-oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (aka 4-hydroxyifosfamide)
P: None of the above. | [B; A; K] |
<Instruct>: Given the context 'Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; cyclophosphamide; ifosfamide]
<Options>: A: 2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)tetrahydro-3-hydroxy-, 2-oxide (aka 3-hydroxycyclophosphamide)
B: cyclophosphamide-mustard (aka aldophosphamide)
C: chloroacetaldehyde
D: cyanoacetaldehyde
E: acetochlor
F: 2h-1,3,2-oxazaphosphorin-2-amine, n,3-bis(2-chloroethyl)tetrahydro-, 2-oxide (aka ifosfamide)
G: cyclophosphamide anhydrous (aka cyclophosphamide)
H: cytosinine
I: carboxycyclophosphamide (aka carboxyphosphamide)
J: isophosphamide mustard
K: isofon
L: lactaldehyde
M: chloroacetone
N: iminocyclophosphamide (aka iminophosphamide)
O: ifosfamide bromide mustard (aka isophosphamide bromide mustard)
P: None of the above. | [C; G; F] |
<Instruct>: Given the context 'Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; cyclophosphamide; ifosfamide]
<Options>: A: lactaldehyde
B: chloroacetaldehyde
C: acetoacetaldehyde
D: chloroacetonitrile
E: isophosphamide mustard
F: 2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)-5,6-dihydro-, 2-oxide (aka iminophosphamide)
G: chlorocytosine (aka 5-chlorocytosine)
H: iodoxamid (aka iodoxamic acid)
I: 4-hydroxyifosfamide
J: cis-5-chlorocyclophosphamide (aka 5-chlorocyclophosphamide)
K: d4-cyclophosphamide
L: iso-endoxan (aka ifosfamide)
M: hydroxyacetaldehyde (aka glycolaldehyde)
N: 2h-1,3,2-oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (aka 4-hydroxyifosfamide)
O: cyclophosphamide anhydrous (aka cyclophosphamide)
P: None of the above. | [B; O; L] |
<Instruct>: Given the context 'Chloroacetaldehyde and its contribution to urotoxicity during treatment with cyclophosphamide or ifosfamide.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; cyclophosphamide; ifosfamide]
<Options>: A: cis-5-chlorocyclophosphamide (aka 5-chlorocyclophosphamide)
B: lactaldehyde
C: 2h-1,3,2-oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (aka 4-hydroxyifosfamide)
D: chloroacetaldehyde
E: acetoacetaldehyde
F: isophosphamide mustard
G: 2h-1,3,2-oxazaphosphorin-2-amine, n,n-bis(2-chloroethyl)-5,6-dihydro-, 2-oxide (aka iminophosphamide)
H: iso-endoxan (aka ifosfamide)
I: d4-cyclophosphamide
J: hydroxyacetaldehyde (aka glycolaldehyde)
K: chloroacetonitrile
L: iodoxamid (aka iodoxamic acid)
M: chlorocytosine (aka 5-chlorocytosine)
N: 4-hydroxyifosfamide
O: None of the above. | [D; O; H] |
<Instruct>: Given the context 'Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; caa]
<Options>: A: aminoacetic acid (aka glycine)
B: chloracetone (aka chloroacetone)
C: cyanoacetic acid
D: chloroacetaldehyde
E: acetochlor
F: acetylcaine
G: carboxycarbonyl-aminoalanine (aka oxalyldiaminopropionic acid)
H: fluoroacetaldehyde
I: casamino acids
J: cyanoacetaldehyde
K: None of the above. | [D; D] |
<Instruct>: Given the context 'Based on clinical data, indicating that chloroacetaldehyde (CAA) is an important metabolite of oxazaphosphorine cytostatics, an experimental study was carried out in order to elucidate the role of CAA in the development of hemorrhagic cystitis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [chloroacetaldehyde; caa]
<Options>: A: acetamides
B: lactaldehyde
C: carboxycarbonyl-aminoalanine (aka oxalyldiaminopropionic acid)
D: 2-chloroacetaldehyde (aka chloroacetaldehyde)
E: casamino acids
F: acetylformaldehyde (aka pyruvaldehyde)
G: 3-chloro-anisaldehyde (aka 3-chloroanisaldehyde)
H: acetoacetaldehyde
I: 3-acetylaminocarnitine
J: aminoacetonitrile
K: None of the above. | [D; D] |
<Instruct>: Given the context 'The data demonstrate that CAA after i.v. administration does not contribute to bladder damage.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [caa]
<Options>: A: caa cyanoacetoacetamide cpd (aka n-(4-(4-tert-butylphenyl)thiazol-2-yl)-n-propyl-2-cyano-3-hydroxy-2-butenamide)
B: aminocaproic acids (aka aminocaproates)
C: acetylcaine
D: casamino acids
E: aminoacetonitrile
F: None of the above. | [F] |
<Instruct>: Given the context 'When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with mesna.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [caa; mesna]
<Options>: A: acetylcarnitine
B: aminoacetonitrile
C: mes compound (aka 2-(n-morpholino)ethanesulfonic acid)
D: mesnum (aka mesna)
E: aminocarnitine (aka emeriamine)
F: methyl mesilate (aka methyl methanesulfonate)
G: aceric acid (aka 3-c-carboxy-5-deoxyxylose)
H: mesilate (aka mesylates)
I: carboxycarbonyl-aminoalanine (aka oxalyldiaminopropionic acid)
J: sodium hydroxymethanesulfonate (aka formaldehyde bisulfite)
K: None of the above. | [K; D] |
<Instruct>: Given the context 'When instilled directly into the bladder, CAA exerts urotoxic effects, it is, however, susceptible to detoxification with mesna.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [caa; mesna]
<Options>: A: mesilates (aka mesylates)
B: aminoacetonitrile
C: ethyl mesilate (aka ethyl methanesulfonate)
D: methanesulfinic acid, sodium salt (aka methanesulfinic acid)
E: aminocaproic acid
F: aceric acid (aka 3-c-carboxy-5-deoxyxylose)
G: sodium hydroxymethanesulfonate (aka formaldehyde bisulfite)
H: casamino acids
I: acetamides
J: ethanesulfonic acid, 2-mercapto-, monosodium salt (aka mesna)
K: None of the above. | [K; J] |
<Instruct>: Given the context 'Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [nitroglycerin]
<Options>: A: glyceryl trinitrate (aka nitroglycerin)
B: nitroglycol (aka ethylene glycol dinitrate)
C: glycerin-1-nitrate (aka glycerol-1-nitrate)
D: nitrogranulogen (aka mechlorethamine)
E: trinonanoin (aka tripelargonin)
F: None of the above. | [A] |
<Instruct>: Given the context 'Twenty common migraine patients received a one sided frontotemporal application of nitroglycerin (10 patients) or placebo ointment (10 patients) in a double blind study.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [nitroglycerin]
<Options>: A: nitrogranulogen (aka mechlorethamine)
B: glycerin-1-nitrate (aka glycerol-1-nitrate)
C: nitroglycol (aka ethylene glycol dinitrate)
D: trinonanoin (aka tripelargonin)
E: None of the above. | [E] |
<Instruct>: Given the context 'Early onset migraine attacks were induced by nitroglycerin in seven out of 10 patients versus no patient in the placebo group.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [nitroglycerin]
<Options>: A: nitrogranulogen (aka mechlorethamine)
B: glycerol-2-nitrate
C: trinonanoin (aka tripelargonin)
D: nitroglycerin
E: glycerin-1-nitrate (aka glycerol-1-nitrate)
F: None of the above. | [D] |
<Instruct>: Given the context 'Subsequently 20 migraine patients, who developed an early onset attack with frontotemporal nitroglycerin, received the drug in a second induction test at other body areas.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [nitroglycerin]
<Options>: A: 2,2',2''- nitrilotrisethanol, trinitrate (ester) (aka trolnitrate)
B: 1,2-glyceryl dinitrate (aka dinitroglycerol)
C: trinonanoin (aka tripelargonin)
D: glycerin-1-nitrate (aka glycerol-1-nitrate)
E: 1,2,3-propanetriol, trinitrate (aka nitroglycerin)
F: None of the above. | [E] |
<Instruct>: Given the context 'Thus the migraine-inducing effect of nitroglycerin seems to depend on direct stimulation of the habitual site of pain, suggesting that the frontotemporal region is of crucial importance in the development of a migraine crisis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [nitroglycerin]
<Options>: A: glycerol-2-nitrate
B: glycerin-1-nitrate (aka glycerol-1-nitrate)
C: nitro dur (aka nitroglycerin)
D: 2,2',2''- nitrilotrisethanol, trinitrate (ester) (aka trolnitrate)
E: trinonanoin (aka tripelargonin)
F: None of the above. | [C] |
<Instruct>: Given the context 'Clotiazepam-induced acute hepatitis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam]
<Options>: A: chlordesmethyldiazepam
B: n-desmethyladinozolam (aka mono-n-demethyladinazolam)
C: tetrazepam
D: 2h-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (aka clotiazepam)
E: n-desmethylmetaclazepam
F: None of the above. | [D] |
<Instruct>: Given the context 'We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam; thienodiazepine]
<Options>: A: desmethylmedazepam
B: 2h-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (aka clotiazepam)
C: tiaaptazepine (aka 2-methyl-1,3,4,14b-tetrahydro-2h-pyrazino(2,1-d)pyrrolo(1,2-b) (1,2,5)benzothiadiazepine 10,10-dioxide)
D: thienodiazepine substance
E: tetrazepam
F: pyridyldithioethylamine
G: clotam (aka tolfenamic acid)
H: gen temazepam (aka temazepam)
I: dibenzo(1,4,5)thiadiazepine
J: thienopyrrole
K: None of the above. | [B; D] |
<Instruct>: Given the context 'We report the case of a patient who developed acute hepatitis with extensive hepatocellular necrosis, 7 months after the onset of administration of clotiazepam, a thienodiazepine derivative.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam; thienodiazepine]
<Options>: A: n-desmethyladinozolam (aka mono-n-demethyladinazolam)
B: thienodiltiazem (aka 4-(2-dimethylaminoethyl)-4,5,6,7-tetrahydro-7-(4-methoxyphenyl)-5-oxothieno(2,3-b)(1,4)thiazepin-6-yl acetate)
C: desmethylclobazam
D: dibenzo(1,4,5)thiadiazepine
E: thienodiazepine substance
F: demethyldiazepam (aka nordazepam)
G: desmethylmedazepam
H: 3,4-dihydro-1h-thieno(3,2-e)(1,4)diazepine-2,5-dione
I: thienopyrrole
J: clotiazepam
K: None of the above. | [J; E] |
<Instruct>: Given the context 'Clotiazepam withdrawal was followed by prompt recovery.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam]
<Options>: A: clotam (aka tolfenamic acid)
B: tetrazepam
C: chlordiazepam (aka 4'-chlorodiazepam)
D: camazepam
E: clotiazepam
F: None of the above. | [E] |
<Instruct>: Given the context 'The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with recovery and did not induce any relapse of hepatitis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [benzodiazepines; clotiazepam]
<Options>: A: diazepam
B: n-desmethyladinozolam (aka mono-n-demethyladinazolam)
C: clazepam
D: benzodixine (aka benzoral)
E: clotam (aka tolfenamic acid)
F: tetrazepam
G: 2h-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (aka clotiazepam)
H: diebs (aka bis(2-(n-phenylcarboxamido)phenyl)diselenide)
I: 1,4-benzodiazepine (aka bz-423)
J: benzodiazepine compounds (aka benzodiazepines)
K: None of the above. | [J; G] |
<Instruct>: Given the context 'The administration of several benzodiazepines, chemically related to clotiazepam, did not interfere with recovery and did not induce any relapse of hepatitis.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [benzodiazepines; clotiazepam]
<Options>: A: demethyldiazepam (aka nordazepam)
B: n-desmethylmetaclazepam
C: benzodiazepine compounds (aka benzodiazepines)
D: 1,2-diazabenzene (aka pyridazine)
E: triazolo(4,3-d)benzodiazepine
F: 2h-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (aka clotiazepam)
G: 2'-chloronordiazepam (aka chlordesmethyldiazepam)
H: 1,4-benzodiazepine-2,5-dione (aka bz-423)
I: temazepam
J: clazepam
K: None of the above. | [C; F] |
<Instruct>: Given the context 'This observation shows that clotiazepam can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam; benzodiazepines]
<Options>: A: benzodiazepinones
B: 2'-chloronordiazepam (aka chlordesmethyldiazepam)
C: benzodiazepines
D: 1,2-diazabenzene (aka pyridazine)
E: clazepam
F: desmethylclobazam
G: clotam (aka tolfenamic acid)
H: diazepam
I: 2h-thieno(2,3-e)-1,4-diazepin-2-one, 5-(2-chlorophenyl)-7-ethyl-1,3-dihydro-1-methyl- (aka clotiazepam)
J: diebs (aka bis(2-(n-phenylcarboxamido)phenyl)diselenide)
K: None of the above. | [I; C] |
<Instruct>: Given the context 'This observation shows that clotiazepam can induce acute hepatitis and suggests that there is no cross hepatotoxicity between clotiazepam and several benzodiazepines.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [clotiazepam; benzodiazepines]
<Options>: A: desmethylclobazam
B: 1,4-benzodiazepine (aka bz-423)
C: clotiazepam
D: benzodiazepines
E: demethyldiazepam (aka nordazepam)
F: anxiolytic (aka anti-anxiety agents)
G: tetrazepam
H: n-desmethyladinozolam (aka mono-n-demethyladinazolam)
I: diazepam
J: temazepam
K: None of the above. | [C; D] |
<Instruct>: Given the context 'Arterial hypertension as a complication of prolonged ketoconazole treatment.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [ketoconazole]
<Options>: A: azaconazole
B: oleoylketoconazole (aka ketoconazole oleate)
C: metconazole
D: sulconazole
E: ketoconazole
F: None of the above. | [E] |
<Instruct>: Given the context 'Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [ketoconazole]
<Options>: A: ketoconazole
B: terconazole
C: croconazole
D: oxyconazole (aka oxiconazole)
E: epoxyconazole (aka epoxiconazole)
F: None of the above. | [A] |
<Instruct>: Given the context 'In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated hypertension 31 (patient 1) and 52 weeks (patient 2) after treatment.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cortisol; ketoconazole]
<Options>: A: cortan (aka prednisone)
B: cortagen (aka alanyl-glutamyl-aspartylprolyine)
C: tetraconazole
D: tetrahydrocortisone
E: hydrocortisone, (11 alpha)-isomer (aka hydrocortisone)
F: deacylketoconazole
G: epoxyconazole (aka epoxiconazole)
H: ketoconazole
I: cortol
J: 4-ketoniridazole
K: None of the above. | [E; H] |
<Instruct>: Given the context 'In both cases normal plasma and urinary free cortisol levels had been achieved following ketoconazole therapy, yet continuous blood pressure monitoring demonstrated hypertension 31 (patient 1) and 52 weeks (patient 2) after treatment.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cortisol; ketoconazole]
<Options>: A: ketoconazole
B: terconazole
C: cortol, (11beta)-isomer (aka cortol)
D: sulconazole
E: cortalcerone
F: oxyconazole (aka oxiconazole)
G: tetraconazole
H: westcort (aka hydrocortisone valerate)
I: corticosterone
J: hydrocortisone, (11 alpha)-isomer (aka hydrocortisone)
K: None of the above. | [J; A] |
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