instruction stringlengths 223 1.46k | input stringlengths 68 1.85k | response stringlengths 3 12 |
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<Instruct>: Given the context 'In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [deoxycorticosterone; 11-deoxycortisol]
<Options>: A: 5-dihydrocorticosterone
B: deoxycorticosterone (aka desoxycorticosterone)
C: 21-deoxycortisone
D: 21-dehydrocortisol, (11alpha)-isomer (aka 21-dehydrocortisol)
E: 21-deoxycortisol
F: 19-oxo-deoxycorticosterone
G: 5 alpha-dihydro-11-deoxycorticosterone (a... | [B; H] |
<Instruct>: Given the context 'In patient 1, plasma levels of deoxycorticosterone and 11-deoxycortisol were elevated.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [deoxycorticosterone; 11-deoxycortisol]
<Options>: A: 21-deoxycortisol
B: deoxycorticosterone-21-acetate (aka desoxycorticosterone acetate)
C: tetrahydrodeoxycortisol (aka tetrahydro-11-deoxycortisol)
D: delta(1)-11-oxa-11-deoxycortisol
E: 5-dihydrocorticosterone
F: tetrahydro-11-dehydrocorticosterone
G: de... | [G; H] |
<Instruct>: Given the context 'In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [deoxycorticosterone; 11-deoxycortisol; aldosterone]
<Options>: A: arterenol (aka norepinephrine)
B: 11-deoxycortisol (aka cortodoxone)
C: 11-deoxycorticosterone-1-ene
D: tetrahydro-11-dehydrocorticosterone
E: adrenalone
F: androstenolone (aka dehydroepiandrosterone)
G: aldosterone, (+-)-isomer (aka aldoste... | [K; B; G] |
<Instruct>: Given the context 'In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [deoxycorticosterone; 11-deoxycortisol; aldosterone]
<Options>: A: 11-dehydrocorticosterone
B: 21-deoxycortisol
C: adrenalone
D: androstanolone (aka dihydrotestosterone)
E: tetrahydro-11-dehydrocorticosterone
F: delta(1)-11-oxa-11-deoxycortisol
G: deoxycorticosterone (aka desoxycorticosterone)
H: aldosteron... | [G; O; H] |
<Instruct>: Given the context 'In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [deoxycorticosterone; 11-deoxycortisol; aldosterone]
<Options>: A: aldosterone, (11 beta,17 alpha)-isomer (aka aldosterone)
B: epinephrine
C: tetrahydrodesoxycorticosterone (aka tetrahydrodeoxycorticosterone)
D: 11-dehydrocorticosterone
E: arterenol (aka norepinephrine)
F: 11 desoxycortisone (aka cortodoxon... | [L; F; A] |
<Instruct>: Given the context 'In patient 2, in addition to an increase in both deoxycorticosterone and 11-deoxycortisol levels, plasma aldosterone values were raised, with a concomitant suppression of renin levels.', select the correct biomedical concept for each mention using the provided options. In the answer, list... | <Mentions>: [deoxycorticosterone; 11-deoxycortisol; aldosterone]
<Options>: A: desoxycorticosterone
B: 11-deoxycorticosterone-1-ene
C: 11 desoxycortisone (aka cortodoxone)
D: 11-dehydrocorticosterone
E: deoxycorticosterone 21 acetate (aka desoxycorticosterone acetate)
F: tetrahydro-11-dehydrocorticosterone
G: aldol (ak... | [A; C; H] |
<Instruct>: Given the context 'Our findings show that long-term treatment with high doses of ketoconazole may induce enzyme blockade leading to mineralocorticoid-related hypertension.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [ketoconazole]
<Options>: A: ketoconazole
B: ketoconazole oleate
C: ketocyclazocine (aka ketazocine)
D: terconazole
E: epoxyconazole (aka epoxiconazole)
F: None of the above. | [A] |
<Instruct>: Given the context 'Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each... | <Mentions>: [angiotensin; captopril]
<Options>: A: angiotensin (aka angiotensins)
B: angiotensinogen
C: angiotrophin (aka angiotrofin)
D: captan
E: angiotensin iv (aka angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-)
F: angiotensin-(1-5) (aka angiotensin ii (1-5))
G: s-benzoyl captopril, (s)-isomer (aka s-benzoyl captopr... | [A; J] |
<Instruct>: Given the context 'Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each... | <Mentions>: [angiotensin; captopril]
<Options>: A: angiotensin i (rat) (aka angiotensin i, ile(5)-)
B: angiotensin ii
C: angiotensin (aka angiotensins)
D: angiotensin iii
E: captisol (aka sbe4-beta-cyclodextrin)
F: captopril disulfide
G: angiotensin (1-7) (aka angiotensin i (1-7))
H: captopril, hydrochlorothiazide drug... | [C; I] |
<Instruct>: Given the context 'Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man.', select the correct biomedical concept for each me... | <Mentions>: [tranexamic acid; amca]
<Options>: A: atmca cpd (aka 1,3,5-trimethoxy-2-(9-anthracenyl)methylamino-4,6-diaminocyclohexane)
B: n-amcc (aka n-acetyl-s-(n-methylcarbamoyl)cysteine)
C: 3-amino-1,1,3-propanetricarboxylic acid (aka 1-carboxyglutamic acid)
D: amidotricoic acid (aka diatrizoate meglumine)
E: tranex... | [I; I] |
<Instruct>: Given the context 'Induction of intravascular coagulation and inhibition of fibrinolysis by injection of thrombin and tranexamic acid (AMCA) in the rat gives rise to pulmonary and renal insufficiency resembling that occurring after trauma or sepsis in man.', select the correct biomedical concept for each me... | <Mentions>: [tranexamic acid; amca]
<Options>: A: gly-amc-3-acetic acid (aka glycyl-7-amino-4-methylcoumarin-3-acetic acid)
B: iothalamic acid
C: 1,1,2-ethanetricarboxylic acid, 2-amino- (aka beta-carboxyaspartic acid)
D: n-amcc (aka n-acetyl-s-(n-methylcarbamoyl)cysteine)
E: aamca cpd (aka arachidonyl 7-amino, 4-methy... | [F; F] |
<Instruct>: Given the context 'Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insufficiency in this rat model.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [captopril; angiotensin]
<Options>: A: angiotensins
B: captopril-cysteine disulfide (aka captopril-cysteine)
C: angiotensin iv (aka angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-)
D: angiotensin (1-5) (aka angiotensin ii (1-5))
E: angiotensin iii
F: captopril ethyl ester
G: angiotensin i (rat) (aka angiotens... | [J; A] |
<Instruct>: Given the context 'Injection of Captopril (1 mg/kg), an inhibitor of angiotensin converting enzyme (ACE), reduced both pulmonary and renal insufficiency in this rat model.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for ea... | <Mentions>: [captopril; angiotensin]
<Options>: A: l-proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (s)- (aka captopril)
B: angiotensinogen
C: angiotensin a
D: tiopronin
E: angiotensin (1-7) (aka angiotensin i (1-7))
F: captisol (aka sbe4-beta-cyclodextrin)
G: captopril disulfide
H: angiotensin (aka angiotensins)
I: an... | [A; H] |
<Instruct>: Given the context 'The contents of albumin in the lungs were not changed, indicating that Captopril did not influence the extravasation of protein.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by... | <Mentions>: [captopril]
<Options>: A: captopril ethyl ester
B: captan
C: captagon (aka fenethylline)
D: tiopronin
E: (s)-1-(3-mercapto-2-methyl-1-oxopropyl)-l-proline (aka captopril)
F: None of the above. | [E] |
<Instruct>: Given the context 'The contents of albumin in the lungs were not changed, indicating that Captopril did not influence the extravasation of protein.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by... | <Mentions>: [captopril]
<Options>: A: captan
B: captagon (aka fenethylline)
C: captopril ethyl ester
D: tiopronin
E: None of the above. | [E] |
<Instruct>: Given the context 'Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [urea; captopril]
<Options>: A: captax
B: amide (aka amides)
C: carbamide (aka urea)
D: l-proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (s)- (aka captopril)
E: captopril disulfide
F: captopril-l-cysteine (aka captopril-cysteine)
G: thiourea
H: n-ethylurea (aka ethylurea)
I: captopril ethyl ester
J: ethamid... | [C; D] |
<Instruct>: Given the context 'Renal damage as reflected by an increase in serum urea and in kidney weight was prevented by Captopril.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [urea; captopril]
<Options>: A: carbamide plus
B: carbamate (aka carbamates)
C: captan
D: thiourea
E: carbamide (aka urea)
F: pentoprilat
G: captax
H: captopril ethyl ester
I: urea nitrate
J: l-proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (s)- (aka captopril)
K: None of the above. | [E; J] |
<Instruct>: Given the context 'The amount of fibrin in the kidneys was also considerably lower than in animals which received thrombin and AMCA alone.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolo... | <Mentions>: [amca]
<Options>: A: amaa acid (aka alpha-amino-3-(hydroxy)-5-methyl-4-isoxazoleacetic acid)
B: cis-amcha (aka cis-4-aminomethylcyclohexane-1-carboxylic acid)
C: 2-amcpa (aka 2-amino-3-(7-methoxy-4-coumaryl)propionic acid)
D: (3h)-amc (aka 1-cyano-2-(4-azidobenzoylethyl)-3-(2-(((5-methyl-4-imidazolyl)methyl... | [E] |
<Instruct>: Given the context 'It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin).', select the correct biomedical concept for each... | <Mentions>: [captopril; angiotension ii; prostacyclin; bradykinin]
<Options>: A: angiotensin ii, 2-l-histidine-5-l-isoleucine- (aka angiotensin ii, his(2)-ile(5)-)
B: bradykininogen
C: 4-tyr(p)-angiotensin ii (aka phosphotyrosylangiotensin ii)
D: ornitho-kinin
E: prostaglandin i3
F: captax
G: bradykinin
H: captagon (ak... | [Q; S; T; G] |
<Instruct>: Given the context 'It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin).', select the correct biomedical concept for each... | <Mentions>: [captopril; angiotension ii; prostacyclin; bradykinin]
<Options>: A: bradykinin
B: bradykinin, tyrosine- (aka bradykinin, tyr-)
C: (des-1,2,3)angiotensin ii (aka angiotensin pentapeptide)
D: human angiotensin iv (aka angiotensin ii, des-asp(1)-des-arg(2)-ile(5)-)
E: angiotensin i (human) (aka angiotensin i,... | [M; R; Q; A] |
<Instruct>: Given the context 'It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin).', select the correct biomedical concept for each... | <Mentions>: [captopril; angiotension ii; prostacyclin; bradykinin]
<Options>: A: iloprost
B: pgi3 (aka prostaglandin i3)
C: ornitho-kinin
D: kinins
E: angiotrophin (aka angiotrofin)
F: captagon (aka fenethylline)
G: prostatropin (aka fibroblast growth factor 2)
H: captopril - hydrochlorothiazide (aka captopril, hydroch... | [P; J; L; I] |
<Instruct>: Given the context 'It is suggested that the effects of Captopril on the lungs may be attributable to a vasodilatory effect due to a reduction in the circulating level of Angiotension II and an increase in prostacyclin (secondary to an increase in bradykinin).', select the correct biomedical concept for each... | <Mentions>: [captopril; angiotension ii; prostacyclin; bradykinin]
<Options>: A: ornitho-kinin
B: angiotrophin (aka angiotrofin)
C: kinin (aka kinins)
D: l-proline, 1-(3-mercapto-2-methyl-1-oxopropyl)-, (s)- (aka captopril)
E: captan
F: bradykinin, (1-d-arg)-isomer (aka bradykinin)
G: angiotensin ii
H: t-kinin
I: 4-phe... | [D; G; P; F] |
<Instruct>: Given the context 'Captopril may, by the same mechanism, reduce the increase in glomerular filtration that is known to occur after an injection of thrombin, thereby diminishing the aggregation of fibrin monomers in the glomeruli, with the result that less fibrin will be deposited and thus less kidney damage... | <Mentions>: [captopril]
<Options>: A: s-benzoyl captopril, (s)-isomer (aka s-benzoyl captopril)
B: captisol (aka sbe4-beta-cyclodextrin)
C: captopril
D: tiopronin
E: stenopril
F: None of the above. | [C] |
<Instruct>: Given the context 'A randomized comparison of labetalol and nitroprusside for induced hypotension.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [labetalol; nitroprusside]
<Options>: A: o(4)-nprt (aka o-4-propylthymine)
B: sodium nitroprusside adenine complex
C: centralagol (aka proxibarbal)
D: labrasol
E: normacol
F: labopal (aka benazepril)
G: nitroproston (aka 1',3'-dinitroglycerol ester of 11(s),15(s)-dihydroxy-9-keto-5z,13e-prostadienoic acid)
... | [H; J] |
<Instruct>: Given the context 'A randomized comparison of labetalol and nitroprusside for induced hypotension.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [labetalol; nitroprusside]
<Options>: A: normacol
B: o(4)-nprt (aka o-4-propylthymine)
C: apolabetalol (aka labetalol)
D: phe-pro-arg-nitrile (aka phenylalanyl-prolyl-arginine nitrile)
E: nitroprusside
F: labrasol
G: centralagol (aka proxibarbal)
H: npr cpd (aka 4-nitrophenylribofuranoside)
I: levonor (aka ... | [C; E] |
<Instruct>: Given the context 'In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures.', select the correct biomedical concept for each mention using the provided options. In the answer, list th... | <Mentions>: [labetalol; nitroprusside]
<Options>: A: labrasol
B: phe-pro-arg-nitrile (aka phenylalanyl-prolyl-arginine nitrile)
C: npr cpd (aka 4-nitrophenylribofuranoside)
D: ret-no (aka isatidine)
E: levonor (aka norepinephrine)
F: taleranol
G: r,r labetalol (aka labetalol)
H: nitroprusside, disodium salt, dihydrate ... | [G; H] |
<Instruct>: Given the context 'In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures.', select the correct biomedical concept for each mention using the provided options. In the answer, list th... | <Mentions>: [labetalol; nitroprusside]
<Options>: A: sodium nitroprusside adenine complex
B: labrasol
C: labdane
D: centralagol (aka proxibarbal)
E: labetalol, (r,r)-isomer (aka labetalol)
F: trimethaphan nitroprusside (aka trimetaphan nitroprusside)
G: npr cpd (aka 4-nitrophenylribofuranoside)
H: labopal (aka benazepr... | [E; J] |
<Instruct>: Given the context 'In a randomized study, labetalol-induced hypotension and nitroprusside-induced hypotension were compared in 20 patients (10 in each group) scheduled for major orthopedic procedures.', select the correct biomedical concept for each mention using the provided options. In the answer, list th... | <Mentions>: [labetalol; nitroprusside]
<Options>: A: disodium salt nitroprusside (aka nitroprusside)
B: labdane
C: nitroxycarnitine nitrate
D: trimethaphan nitroprusside (aka trimetaphan nitroprusside)
E: centralagol (aka proxibarbal)
F: labopal (aka benazepril)
G: npr cpd (aka 4-nitrophenylribofuranoside)
H: labrasol
... | [J; A] |
<Instruct>: Given the context 'Nitroprusside infusion was associated with a significant (p less than 0.05) increase in heart rate and cardiac output; rebound hypertension was observed in three patients after discontinuation of nitroprusside.', select the correct biomedical concept for each mention using the provided op... | <Mentions>: [nitroprusside]
<Options>: A: nitroprusside, disodium salt (aka nitroprusside)
B: o(4)-nprt (aka o-4-propylthymine)
C: phe-pro-arg-nitrile (aka phenylalanyl-prolyl-arginine nitrile)
D: nitroxycarnitine nitrate
E: ret-no (aka isatidine)
F: None of the above. | [A] |
<Instruct>: Given the context 'Labetalol administration was not associated with any of these findings.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [labetalol]
<Options>: A: labdane
B: r,r-labetalol (aka labetalol)
C: labrasol
D: xipranolol
E: apo levobunolol (aka levobunolol)
F: None of the above. | [B] |
<Instruct>: Given the context 'Arterial PO2 decreased in both groups.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [po2]
<Options>: A: po-2
B: oxygen
C: peroxide, nitrogen (aka nitrogen dioxide)
D: phenoxy ion (aka phenoxy radical)
E: oxidative potential water
F: None of the above. | [A] |
<Instruct>: Given the context 'It was concluded that labetalol offers advantages over nitroprusside.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [labetalol; nitroprusside]
<Options>: A: trimetaphan nitroprusside
B: nitroprusside, disodium salt, dihydrate (aka nitroprusside)
C: npr cpd (aka 4-nitrophenylribofuranoside)
D: phe-pro-arg-nitrile (aka phenylalanyl-prolyl-arginine nitrile)
E: ret-no (aka isatidine)
F: r,r-labetalol (aka labetalol)
G: taler... | [F; B] |
<Instruct>: Given the context 'It was concluded that labetalol offers advantages over nitroprusside.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [labetalol; nitroprusside]
<Options>: A: labdane
B: taleranol
C: cppn (aka 3-carboxypropyl-(2-propenyl)nitrosamine)
D: nitroferricyanide (aka nitroprusside)
E: phe-pro-arg-nitrile (aka phenylalanyl-prolyl-arginine nitrile)
F: trimethaphan nitroprusside (aka trimetaphan nitroprusside)
G: labrasol
H: normacol... | [I; D] |
<Instruct>: Given the context 'Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon... | <Mentions>: [carbamazepine; folate]
<Options>: A: carbamazepine-10,11-trans-dihydrodiol (aka carbamazepine-10,11-dihydrodiol)
B: oxcarbazepine
C: carbamazepine 10,11-epoxide (aka carbamazepine epoxide)
D: folacin (aka folic acid)
E: pterin (aka pterins)
F: vitamin f (aka arachidonic acid)
G: folpet
H: carbamazepine
I: ... | [H; D] |
<Instruct>: Given the context 'Chronic carbamazepine treatment in the rat: efficacy, toxicity, and effect on plasma and tissue folate concentrations.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon... | <Mentions>: [carbamazepine; folate]
<Options>: A: vitamin f (aka arachidonic acid)
B: carbamann (aka carbachol)
C: pteridine (aka pteridines)
D: carbathin
E: folate (aka folic acid)
F: pterin (aka pterins)
G: carbamazepine-10,11-dihydrodiol
H: b vitamin (aka vitamin b complex)
I: carbamazepine phosphate (aka carbamazep... | [I; E] |
<Instruct>: Given the context 'Folate depletion has often been a problem in chronic antiepileptic drug (AED) therapy.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [folate]
<Options>: A: folate (aka folic acid)
B: folpet
C: pterin (aka pterins)
D: folicitin
E: folicanthine
F: None of the above. | [A] |
<Instruct>: Given the context 'Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [carbamazepine; cbz]
<Options>: A: carbamazepine hydrochloride (aka carbamazepine)
B: carbamazepine epoxide
C: cbz-cysteine (aka benzyloxycarbonylcysteine)
D: cbz-tyroet (aka n-carbobenzyloxytyrosine ethyl ester)
E: carbathin
F: carbamazepine-10,11-dihydrodiol
G: oxcarbazepine
H: cbzm-1,3,3 (aka 1-(2-chloro... | [A; A] |
<Instruct>: Given the context 'Carbamazepine (CBZ), a commonly used AED, has been implicated in some clinical studies.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [carbamazepine; cbz]
<Options>: A: carbazepin (aka carbamazepine)
B: carbamate-bz (aka zinc dibutyldithiocarbamate)
C: carbathin
D: cbz-cysteine (aka benzyloxycarbonylcysteine)
E: carbamazepine-10,11-diol (aka 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide)
F: cbz-serine (aka benzyloxycarbonyl... | [A; A] |
<Instruct>: Given the context 'A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cbz; folate]
<Options>: A: cbzm-1,3,3 (aka 1-(2-chloroethyl)-3-benzyl-3-(methylcarbamoyl)triazene)
B: folic acid
C: vitae (aka tocopherols)
D: cbz-tyroet (aka n-carbobenzyloxytyrosine ethyl ester)
E: cbz-gly (aka n-benzyloxycarbonylglycine)
F: carbazepin (aka carbamazepine)
G: methyl folate (aka 5-methylte... | [F; B] |
<Instruct>: Given the context 'A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cbz; folate]
<Options>: A: cbz-diol (aka 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide)
B: folate (aka folic acid)
C: folicitin
D: pterin (aka pterins)
E: carbazepin (aka carbamazepine)
F: cbi compound (aka 1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one)
G: cbztnp (aka n-benzylox... | [E; B] |
<Instruct>: Given the context 'A rat model was developed to examine the effects of chronic CBZ treatment on folate concentrations in the rat.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cbz; folate]
<Options>: A: methyl folate (aka 5-methyltetrahydrofolate)
B: folicitin
C: vitae (aka tocopherols)
D: pterin (aka pterins)
E: carbendazin (aka carbendazim)
F: carbazepin (aka carbamazepine)
G: cbztnp (aka n-benzyloxycarbonyltyrosine-4-nitrophenyl ester)
H: cbi compound (aka 1,2,9,9a-tetrahydro... | [F; J] |
<Instruct>: Given the context 'In the course of developing this model, a common vehicle, propylene glycol, by itself in high doses, was found to exhibit protective properties against induced seizures and inhibited weight gain.', select the correct biomedical concept for each mention using the provided options. In the a... | <Mentions>: [propylene glycol]
<Options>: A: alcohol-propylene glycol
B: propylene glycol methyl ether
C: propylene oxide
D: glycol, propylene (aka propylene glycol)
E: propyl ether
F: None of the above. | [D] |
<Instruct>: Given the context 'Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct ... | <Mentions>: [hexafluorodiethyl ether; hfde; cbz]
<Options>: A: (1h,1h-perfluoroethyl)(2h-perfluoroethyl)ether (aka 1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane)
B: dex-ffa (aka dextran-flufenamic acid ester)
C: carbamazepine
D: fluoroethanol (aka 2-fluoroethanol)
E: di-2-ethyl-hexyl adipate (aka dioctyl adipate)... | [P; P; C] |
<Instruct>: Given the context 'Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct ... | <Mentions>: [hexafluorodiethyl ether; hfde; cbz]
<Options>: A: (1h,1h-perfluoroethyl)(2h-perfluoroethyl)ether (aka 1,1,2,2-tetrafluoro-1-(2,2,2-trifluoroethoxy)ethane)
B: carbamazepine
C: 1,2,2,2-tetrafluoroethyl difluoromethyl ether (aka desflurane)
D: cbz-diol (aka 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-car... | [P; P; B] |
<Instruct>: Given the context 'Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct ... | <Mentions>: [hexafluorodiethyl ether; hfde; cbz]
<Options>: A: perfluorohexylethane
B: (perfluorohexyl)ethylene (aka 1,1,1,2,2,3,3,4,4,5,5,6,6---tridecafluoro-8-iodo-7-tetradecene)
C: carbamate-bz (aka zinc dibutyldithiocarbamate)
D: cbz-diol (aka 10,11-dihydro-10,11-dihydroxy-5h-dibenzazepine-5-carboxamide)
E: cbz-ser... | [P; P; N] |
<Instruct>: Given the context 'Seizures induced by hexafluorodiethyl ether (HFDE) were also found to be a more sensitive measure of protection by CBZ than seizures induced by maximal electroshock (MES).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct ... | <Mentions>: [hexafluorodiethyl ether; hfde; cbz]
<Options>: A: cbz-serine (aka benzyloxycarbonylserine)
B: cbz-tyroet (aka n-carbobenzyloxytyrosine ethyl ester)
C: hdee cpd (aka 22e-3beta-hydroxy-5alpha,6alpha,8alpha,14alpha-diepoxyergosta-22-en-7-one)
D: 1,2-dichloro-1,1,2,2-tetrafluoroethane (aka freon 114)
E: 18f-fl... | [O; O; O] |
<Instruct>: Given the context 'Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg/kg was continuously protective against HFDE-induced seizures and was minimally toxic as measured by weight gain over 8 weeks of treatment.', select the correct biomedical concept for each mention using the p... | <Mentions>: [cbz; hfde]
<Options>: A: di-2-ethyl-hexyl adipate (aka dioctyl adipate)
B: n-(phenylmethyl)carbazole (aka n-benzylcarbazole)
C: deshydroxy-(18f)fluorocholine (aka deshydroxyfluorocholine)
D: cbz-lll (aka carbobenzoxy-leucyl-leucyl-leucine)
E: carbamate-bz (aka zinc dibutyldithiocarbamate)
F: hfgde (aka dim... | [H; K] |
<Instruct>: Given the context 'Oral administration of CBZ as an aqueous suspension every 8 h at a dose of 250 mg/kg was continuously protective against HFDE-induced seizures and was minimally toxic as measured by weight gain over 8 weeks of treatment.', select the correct biomedical concept for each mention using the p... | <Mentions>: [cbz; hfde]
<Options>: A: deshydroxy-(18f)fluorocholine (aka deshydroxyfluorocholine)
B: 10-hedf (aka 10 beta-hydroxy-4-estrene-3,17-dione formate)
C: dex-ffa (aka dextran-flufenamic acid ester)
D: docosahexaenoic acid ethyl ester (aka 4,7,10,13,16,19-docosahexaenoic acid ethyl ester)
E: hdee cpd (aka 22e-3... | [H; K] |
<Instruct>: Given the context 'The CBZ levels measured in plasma and brain of these animals, however, were below those normally considered protective.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolo... | <Mentions>: [cbz]
<Options>: A: n-benzylcarbazole
B: cbz-lll (aka carbobenzoxy-leucyl-leucyl-leucine)
C: cbz-valpheh (aka calpain inhibitor iii)
D: cbz-cysteine (aka benzyloxycarbonylcysteine)
E: carbamazepine
F: None of the above. | [E] |
<Instruct>: Given the context 'This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat, and, indeed, the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [cbz; folate]
<Options>: A: cbzm-1,3,3 (aka 1-(2-chloroethyl)-3-benzyl-3-(methylcarbamoyl)triazene)
B: carbamate-bz (aka zinc dibutyldithiocarbamate)
C: folex (aka merphos)
D: vitamin f (aka arachidonic acid)
E: carbazepin (aka carbamazepine)
F: vitamin b9 (aka folic acid)
G: pterin (aka pterins)
H: cbz-tyr... | [E; F] |
<Instruct>: Given the context 'This treatment with CBZ had no apparent adverse effect on folate concentrations in the rat, and, indeed, the folate concentration increased in liver after 6 weeks of treatment and in plasma at 8 weeks of treatment.', select the correct biomedical concept for each mention using the provide... | <Mentions>: [cbz; folate]
<Options>: A: cbi compound (aka 1,2,9,9a-tetrahydrocyclopropa(1,2-c)benz(1,2-e)indol-4-one)
B: ox-cbz (aka oxcarbamazepine)
C: cbz-serine (aka benzyloxycarbonylserine)
D: carbazepin (aka carbamazepine)
E: folicanthine
F: vitamin b9 (aka folic acid)
G: pteridine (aka pteridines)
H: folex (aka m... | [D; F] |
<Instruct>: Given the context 'In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor.', select the correct biomedical conc... | <Mentions>: [sodium; norepinephrine; epinephrine]
<Options>: A: sodium nitrite
B: norephrine (aka nordefrin)
C: glutamate, sodium (aka sodium glutamate)
D: level, sodium ion (aka sodium)
E: noradrenalone
F: norepinephrine glucuronide
G: sodium compounds
H: sodium sulfide
I: noradrenaline (aka norepinephrine)
J: alpha-m... | [D; I; K] |
<Instruct>: Given the context 'In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor.', select the correct biomedical conc... | <Mentions>: [sodium; norepinephrine; epinephrine]
<Options>: A: sodium
B: epinemin
C: glutamate, sodium (aka sodium glutamate)
D: norephrine (aka nordefrin)
E: norepinephrine glucuronide
F: norphenylephrine (aka norfenefrine)
G: norepinephrine, (+)-isomer (aka norepinephrine)
H: epinephrine, racemic mixture (aka racepi... | [A; G; I] |
<Instruct>: Given the context 'In six conscious, trained dogs, maintained on a normal sodium intake of 2 to 4 mEq/kg/day, sympathetic activity was assessed as the release rate of norepinephrine and epinephrine during 15-minute i.v. infusions of human alpha-atrial natriuretic factor.', select the correct biomedical conc... | <Mentions>: [sodium; norepinephrine; epinephrine]
<Options>: A: level, sodium ion (aka sodium)
B: catecholamine (aka catecholamines)
C: epinephrine
D: compounds, sodium (aka sodium compounds)
E: epinemin
F: sodium nitrate
G: sodium aspartate (aka aspartic acid)
H: norepinephrine glucuronide
I: adrenergic (aka adrenergi... | [A; J; C] |
<Instruct>: Given the context 'Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation... | <Mentions>: [norepinephrine; hydralazine; nitroglycerin]
<Options>: A: norepinephrine glucuronide
B: histidyl-hydrazine (aka histidylhydrazine)
C: 2,2',2''- nitrilotrisethanol, trinitrate (ester) (aka trolnitrate)
D: nitrogranulogen (aka mechlorethamine)
E: ethylnorepinephrine
F: levonor (aka norepinephrine)
G: norsyne... | [F; K; M] |
<Instruct>: Given the context 'Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation... | <Mentions>: [norepinephrine; hydralazine; nitroglycerin]
<Options>: A: nitro-dur (aka nitroglycerin)
B: glycerin-1-nitrate (aka glycerol-1-nitrate)
C: hydralazine
D: histidyl-hydrazine (aka histidylhydrazine)
E: levonorepinephrine (aka norepinephrine)
F: glyceryl 1,3-dinitrate (aka dinitroglycerol)
G: hydralazine aceto... | [E; C; A] |
<Instruct>: Given the context 'Mean arterial pressure (as a percentage of control +/- SEM) during randomized infusions of 0.03, 0.1, 0.3, or 1.0 microgram/kg/min was 99 +/- 1, 95 +/- 1 (p less than 0.05), 93 +/- 1 (p less than 0.01), or 79 +/- 6% (p less than 0.001), respectively, but no tachycardia and no augmentation... | <Mentions>: [norepinephrine; hydralazine; nitroglycerin]
<Options>: A: levorine (aka candicidin)
B: hydramitrazine (aka meladrazine)
C: histidyl-hydrazine (aka histidylhydrazine)
D: nitrogranulogen (aka mechlorethamine)
E: hydrazinopyridazine (aka oxdralazine)
F: 1,2-glyceryl dinitrate (aka dinitroglycerol)
G: ethylnor... | [H; N; L] |
<Instruct>: Given the context 'The release rate of epinephrine (control, 6.7 +/- 0.6 ng/kg/min) declined immediately during infusions of atrial natriuretic factor to a minimum of 49 +/- 5% of control (p less than 0.001) during 0.1 microgram/kg/min and to 63 +/- 5% (0.1 greater than p greater than 0.05) or 95 +/- 13% (n... | <Mentions>: [epinephrine]
<Options>: A: alpha-methylepinephrine
B: noradrenaline (aka norepinephrine)
C: epinephrine
D: adrenalone
E: norsynephrine (aka octopamine)
F: None of the above. | [C] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [etoposide; methotrexate; cyclophosphamide; actomycin-d]
<Options>: A: d4-cyclophosphamide
B: methanopterin
C: aplasmomycin
D: methotrexate-alpha-arginine, (l-arg, dl-gln)-isomer (aka methotrexate-alpha-arginine)
E: etoprine
F: 4'-ester etoposide
G: cis-5-chlorocyclophosphamide (aka 5-chlorocyclophosphamide... | [M; H; O; S] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [etoposide; methotrexate; cyclophosphamide; actomycin-d]
<Options>: A: dictyopterin (aka biopterins)
B: acidomycin (aka mycobacidin)
C: ethyl ecgonine
D: e-epu (aka 5-ethyl-1-ethoxymethyl-6-(phenylthio)uracil)
E: 2h-1,3,2-oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide (... | [G; K; J; I] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [etoposide; methotrexate; cyclophosphamide; actomycin-d]
<Options>: A: cyclophosphamide monohydrate (aka cyclophosphamide)
B: methotrexate-alpha-arginine, (l-arg, l-gln)-isomer (aka methotrexate-alpha-arginine)
C: 2h-1,3,2-oxazaphosphorin-4-ol, 3-(2-chloroethyl)-2-((2-chloroethyl)amino)tetrahydro-, 2-oxide ... | [I; P; A; G] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [etoposide; methotrexate; cyclophosphamide; actomycin-d]
<Options>: A: etophamide (aka etofamide)
B: etoposide, (5a alpha,9 alpha)-isomer (aka etoposide)
C: desaminoactinomycin c
D: amphomycin
E: methanopterin
F: cytosaminomycin d
G: methotrexate-alpha-arginine, (l-arg, l-gln)-isomer (aka methotrexate-alpha... | [B; T; P; H] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [etoposide; methotrexate; cyclophosphamide; actomycin-d]
<Options>: A: etoposide, ortho-quinone derivative (aka vpq compound)
B: methotrexate-gamma-methylamide
C: actinomycin d (aka dactinomycin)
D: d4-cyclophosphamide
E: methotrexate
F: methotrexate-gamma-dimethylamide
G: cytophosphane (aka cyclophosphamid... | [I; E; G; C] |
<Instruct>: Given the context 'The multiple drug schema consisted of: Etoposide 16.213, Methotrexate, Cyclophosphamide, Actomycin-D, and Cisplatin.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [cisplatin]
<Options>: A: platinic chloride
B: cis-dichlorobis(pyridine)platinum (aka dichloro(dipyridine)platinum ii)
C: platino (aka cisplatin)
D: phenanthriplatin
E: platinum chloride
F: None of the above. | [C] |
<Instruct>: Given the context 'On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicol... | <Mentions>: [methotrexate; etoposide; cyclophosphamide]
<Options>: A: methotrexate-alpha glutamate
B: methotrexate, (dl)-isomer (aka methotrexate)
C: etophamide (aka etofamide)
D: carboxycyclophosphamide (aka carboxyphosphamide)
E: iminocyclophosphamide (aka iminophosphamide)
F: dictyopterin (aka biopterins)
G: methotr... | [B; O; M] |
<Instruct>: Given the context 'On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicol... | <Mentions>: [methotrexate; etoposide; cyclophosphamide]
<Options>: A: 5-chlorocyclophosphamide
B: etoprine
C: iminocyclophosphamide (aka iminophosphamide)
D: cytoxan (aka cyclophosphamide)
E: etoposide phosphate
F: methotrexate-alpha-monoamide
G: dictyopterin (aka biopterins)
H: etoposide glucuronide
I: methanopterin
J... | [O; L; D] |
<Instruct>: Given the context 'On the first day of the schedule, moderate high doses of Methotrexate, Etoposide and Cyclophosphamide were administered.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicol... | <Mentions>: [methotrexate; etoposide; cyclophosphamide]
<Options>: A: ethyl ecgonine
B: etoposide glucuronide
C: etoposide, (5a alpha,9 alpha)-isomer (aka etoposide)
D: iminocyclophosphamide (aka iminophosphamide)
E: methotrexate
F: cytosinine
G: trans-5-chlorocyclophosphamide (aka 5-chlorocyclophosphamide)
H: methotre... | [E; C; J] |
<Instruct>: Given the context 'Impotence was more common among male patients than controls and was found to be associated with co-morbidity and the taking of methotrexate.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, ... | <Mentions>: [methotrexate]
<Options>: A: methotrexate-alpha-monoamide
B: lysine-methotrexate
C: methotrexate alpha-aspartate
D: dictyopterin (aka biopterins)
E: amethopterin (aka methotrexate)
F: None of the above. | [E] |
<Instruct>: Given the context 'Does paracetamol cause urothelial cancer or renal papillary necrosis?', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [paracetamol]
<Options>: A: paracetamol (aka acetaminophen)
B: apapa (aka adenylyl-(3'-5')-adenylyl-(3'-5')-adenosine)
C: p-acetoxyacetanilide (aka acetoxyacetanilide)
D: p-(acetylamino)phenol
E: acetyl-2-aminophenol (aka 3-hydroxyacetanilide)
F: None of the above. | [A] |
<Instruct>: Given the context 'The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls.', select the correct biomedical concept for ... | <Mentions>: [phenacetin; paracetamol]
<Options>: A: phenacylamine
B: p-(acetylamino)phenol
C: p-acetoxyacetanilide (aka acetoxyacetanilide)
D: fenitoin (aka phenytoin)
E: phenacetin
F: paracetamol (aka acetaminophen)
G: phenylacetate (aka phenylacetic acid)
H: o-hydroxyacetanilide (aka 2-hydroxyacetanilide)
I: p-acetyl... | [E; F] |
<Instruct>: Given the context 'The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls.', select the correct biomedical concept for ... | <Mentions>: [phenacetin; paracetamol]
<Options>: A: alpha-phenylacetoacetonitrile
B: acetyl-m-aminophenol (aka 3-hydroxyacetanilide)
C: p-(acetylamino)phenol
D: p-acetylphenylalanine (aka 3-(4-acetylphenyl)-2-aminopropanoic acid)
E: phenacetin
F: p-amino acetanilide (aka 4-aminoacetanilide)
G: acephen (aka acetaminophe... | [E; H] |
<Instruct>: Given the context 'The risk of developing renal papillary necrosis or cancer of the renal pelvis, ureter or bladder associated with consumption of either phenacetin or paracetamol was calculated from data acquired by questionnaire from 381 cases and 808 controls.', select the correct biomedical concept for ... | <Mentions>: [phenacetin; paracetamol]
<Options>: A: acephen (aka acetaminophen)
B: p-acetylphenylalanine (aka 3-(4-acetylphenyl)-2-aminopropanoic acid)
C: phenantoin (aka mephenytoin)
D: p-(acetylamino)phenol
E: alpha-phenylacetoacetonitrile
F: acetyl-m-aminophenol (aka 3-hydroxyacetanilide)
G: phenyl acetate
H: p-amin... | [J; I] |
<Instruct>: Given the context 'The risk of renal papillary necrosis was increased nearly 20-fold by consumption of phenacetin, which also increased the risk for cancer of the renal pelvis and bladder but not for ureteric cancer.', select the correct biomedical concept for each mention using the provided options. In the... | <Mentions>: [phenacetin]
<Options>: A: phenylacetone (aka 1-phenyl-2-propanone)
B: phenylacetonitrile (aka benzyl cyanide)
C: phenalon
D: phenacetin
E: phenesterine (aka phenesterin)
F: None of the above. | [D] |
<Instruct>: Given the context 'By contrast, we were unable to substantiate an increased risk from paracetamol consumption for renal papillary necrosis or any of these cancers although there was a suggestion of an association with cancer of the ureter.', select the correct biomedical concept for each mention using the p... | <Mentions>: [paracetamol]
<Options>: A: p-(acetylamino)phenol
B: o-hydroxyacetanilide (aka 2-hydroxyacetanilide)
C: apap (aka acetaminophen)
D: apapa (aka adenylyl-(3'-5')-adenylyl-(3'-5')-adenosine)
E: p-acetylphenylalanine (aka 3-(4-acetylphenyl)-2-aminopropanoic acid)
F: None of the above. | [C] |
<Instruct>: Given the context 'Dapsone-associated Heinz body hemolytic anemia in a Cambodian woman with hemoglobin E trait.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [dapsone]
<Options>: A: dapsone hydroxylamine (aka 4-amino-4'-hydroxylaminodiphenylsulfone)
B: 4,4'-diaminodiphenyldisulfide
C: diaminodiphenylsulfone (aka dapsone)
D: dapda (aka 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine)
E: dimethyl-diamine-sulfone
F: None of the above. | [C] |
<Instruct>: Given the context 'A Cambodian woman with hemoglobin E trait (AE) and leprosy developed a Heinz body hemolytic anemia while taking a dose of dapsone (50 mg/day) not usually associated with clinical hemolysis.', select the correct biomedical concept for each mention using the provided options. In the answer,... | <Mentions>: [dapsone]
<Options>: A: dapsone
B: 2-sulfamoyl-4,4'-diaminodiphenyl sulfone (aka sdds)
C: dap cpd (aka phosphorodiamidic acid)
D: diaminodiethyldisulfide (aka cystamine)
E: diasone (aka sulfoxone)
F: None of the above. | [A] |
<Instruct>: Given the context 'Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [glutathione; gsh]
<Options>: A: glutathione, oxidized (aka glutathione disulfide)
B: gamma l glutamyl l cysteinylglycine (aka glutathione)
C: gamma-glu-cys (aka gamma-glutamylcysteine)
D: gamma-glutamylglycine
E: glutamate thiol
F: gsh-et (aka glutathione glycylethyl ester)
G: glutathione amide
H: None of ... | [B; B] |
<Instruct>: Given the context 'Her red blood cells (RBCs) had increased incubated Heinz body formation, decreased reduced glutathione (GSH), and decreased GSH stability.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, se... | <Mentions>: [glutathione; gsh]
<Options>: A: gamma-glutamylcystine
B: cyssg (aka cysteine-glutathione disulfide)
C: glutamate thiol
D: s-ethyl glutathione
E: reduced glutathione (aka glutathione)
F: gamma-glutamylglycine
G: gssg (aka glutathione disulfide)
H: glutathione amide
I: None of the above. | [E; E] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: fructosephosphates
B: phosphoenolpyruvate
C: dapsone
D: dapsone hydroxylamine (aka 4-amino-4'-hydroxylaminodiphenylsulfone)
E: glucan phosphate
F: glucose-1-phosphate
G: dimethyl-diamine-sulfone
H: diasone (aka sulfoxone)
I: dap cpd (aka phosphorodiamidic acid)
J: ... | [J; C] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: glucose-1-phosphate
B: diasone (aka sulfoxone)
C: dap cpd (aka phosphorodiamidic acid)
D: dapsone hydroxylamine (aka 4-amino-4'-hydroxylaminodiphenylsulfone)
E: dimethyl-diamine-sulfone
F: dapsone
G: phosphoenolpyruvate
H: glucan phosphate
I: fructosephosphates
J: ... | [J; F] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the dapsone-exposed AE RBCs was increased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: diaminodiphenylsulfone (aka dapsone)
B: diaminodiethyldisulfide (aka cystamine)
C: n,n-diethyl-p-phenylenediamine (aka n,n-diethyl 4-phenylenediamine)
D: fructosephosphates
E: pentosephosphates
F: acedapsone
G: hexosephosphates
H: dapsone hydroxylamine (aka 4-amino... | [E; A] |
<Instruct>: Given the context 'Although the AE RBCs from an individual not taking dapsone had increased incubated Heinz body formation, the GSH content and GSH stability were normal.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [dapsone; gsh]
<Options>: A: diasone (aka sulfoxone)
B: 4,4'-diacetyldiaminodiphenylsulfone (aka acedapsone)
C: reduced glutathione (aka glutathione)
D: gssg (aka glutathione disulfide)
E: 2,2'-diaminodiphenyldisulfide
F: sulfone, 4,4'-diaminophenyl (aka dapsone)
G: diaminodiethyldisulfide (aka cystamine)
H... | [F; C] |
<Instruct>: Given the context 'Although the AE RBCs from an individual not taking dapsone had increased incubated Heinz body formation, the GSH content and GSH stability were normal.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for eac... | <Mentions>: [dapsone; gsh]
<Options>: A: gamma-glutamylcystine
B: cyssg (aka cysteine-glutathione disulfide)
C: disulfide, glutathione (aka glutathione disulfide)
D: dap cpd (aka phosphorodiamidic acid)
E: 4,4'-diaminophenyl sulfone (aka dapsone)
F: reduced glutathione (aka glutathione)
G: dimethyl-diamine-sulfone
H: s... | [E; F] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the non-dapsone-exposed AE RBCs was decreased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: 2,2'-diaminodiphenyldisulfide
B: fructose-6-phosphate
C: l-threo-pentulose 1-phosphate (aka xylulose-1-phosphate)
D: sulfone, 4,4'-diaminophenyl (aka dapsone)
E: xylose 1-phosphate
F: 2-sulfamoyl-4,4'-diaminodiphenyl sulfone (aka sdds)
G: dimethyl-diamine-sulfone
H... | [H; D] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the non-dapsone-exposed AE RBCs was decreased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: 2,2'-diaminodiphenyldisulfide
B: hexosephosphates
C: dapda (aka 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine)
D: sulfone, 4,4'-diaminophenyl (aka dapsone)
E: glucose-1-phosphate
F: phosphoenolpyruvate
G: 4,4'-diaminodiphenylsulfide (aka 4,4'-thiodianiline)
H: fructos... | [J; D] |
<Instruct>: Given the context 'The pentose phosphate shunt activity of the non-dapsone-exposed AE RBCs was decreased compared to normal RBCs.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [pentose phosphate; dapsone]
<Options>: A: 4,4'-diaminodiphenylsulfide (aka 4,4'-thiodianiline)
B: glucose-1-phosphate
C: 2,2'-diaminodiphenyldisulfide
D: phosphoenolpyruvate
E: dapda (aka 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine)
F: fructose-1-phosphate
G: dap cpd (aka phosphorodiamidic acid)
H: pentosep... | [H; J] |
<Instruct>: Given the context 'Thus, AE RBCs appear to have an increased sensitivity to oxidant stress both in vitro and in vivo, since dapsone does not cause hemolytic anemia at this dose in hematologically normal individuals.', select the correct biomedical concept for each mention using the provided options. In the ... | <Mentions>: [dapsone]
<Options>: A: dapda (aka 2'-deoxyadenylyl-(3'-5')-2'-deoxyadenosine)
B: 4,4'-diaminodiphenyldisulfide
C: 4,4'-diaminophenyl sulfone (aka dapsone)
D: dapsone hydroxylamine (aka 4-amino-4'-hydroxylaminodiphenylsulfone)
E: diasone (aka sulfoxone)
F: None of the above. | [C] |
<Instruct>: Given the context 'Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each m... | <Mentions>: [metoprolol; propafenone; diltiazem; sparteine]
<Options>: A: dictyoprolenol
B: sparlon (aka modafinil)
C: pirafen
D: midafenone (aka nizofenone)
E: 4-methylpropranolol
F: sparine (aka promazine)
G: n-monodemethyldiltiazem
H: s-propylcysteine
I: 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-(2-(dimethylamin... | [K; Q; I; J] |
<Instruct>: Given the context 'Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each m... | <Mentions>: [metoprolol; propafenone; diltiazem; sparteine]
<Options>: A: propafenone, (s)-isomer (aka propafenone)
B: deacetyl-n-monodemethyldiltiazem
C: sparinaritin
D: s-propylcysteine
E: midafenone (aka nizofenone)
F: o-demethylmetoprolol
G: pirafen
H: propafenone dimer
I: metoprolol succinate (aka metoprolol)
J: c... | [I; A; J; M] |
<Instruct>: Given the context 'Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each m... | <Mentions>: [metoprolol; propafenone; diltiazem; sparteine]
<Options>: A: pirafen
B: metoprolol succinate (aka metoprolol)
C: proparathormone
D: deacetyl n-monodesmethyl diltiazem
E: sparine (aka promazine)
F: midafenone (aka nizofenone)
G: s-propylcysteine
H: 3,5-methanoproline
I: s-aminopropylcysteine (aka aminopropy... | [B; T; P; O] |
<Instruct>: Given the context 'Severe complications of antianginal drug therapy in a patient identified as a poor metabolizer of metoprolol, propafenone, diltiazem, and sparteine.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each m... | <Mentions>: [metoprolol; propafenone; diltiazem; sparteine]
<Options>: A: 1-(2-methoxyphenoxy)-3-((1-methylethyl)amino)-2-propanol (aka moprolol)
B: deacme-diltiazem (aka deacetyl-n-monodemethyldiltiazem)
C: sparan
D: 3,5-methanoproline
E: diltiazem hydrochloride (aka diltiazem)
F: sparteine, (7s-(7alpha,7aalpha,14alph... | [N; M; E; F] |
<Instruct>: Given the context 'One week prior to admission a therapy with standard doses of metoprolol (100 mg t.i.d.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [metoprolol]
<Options>: A: metoprolol succinate (aka metoprolol)
B: dictyoprolenol
C: 2,4-methanoproline
D: 3,5-methanoproline
E: o-desmethyl metoprolol
F: None of the above. | [A] |
<Instruct>: Given the context 'Two days before admission diltiazem (60 mg b.i.d.) was prescribed in addition.', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, separated by semicolon. | <Mentions>: [diltiazem]
<Options>: A: deacetyl n-monodesmethyl diltiazem
B: tetrazepam
C: thienodiltiazem (aka 4-(2-dimethylaminoethyl)-4,5,6,7-tetrahydro-7-(4-methoxyphenyl)-5-oxothieno(2,3-b)(1,4)thiazepin-6-yl acetate)
D: diltiazem
E: dilazep
F: None of the above. | [D] |
<Instruct>: Given the context 'Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [metoprolol; diltiazem]
<Options>: A: dilazep
B: alpha-hydroxymetoprolol
C: tetrazepam
D: 1-(2-methoxyphenoxy)-3-((1-methylethyl)amino)-2-propanol (aka moprolol)
E: cardizem (aka diltiazem)
F: metoprolol succinate (aka metoprolol)
G: metipranolol
H: thienodiltiazem (aka 4-(2-dimethylaminoethyl)-4,5,6,7-tetr... | [F; E] |
<Instruct>: Given the context 'Analyses of a blood sample revealed unusually high plasma concentrations of metoprolol (greater than 3000 ng/ml) and diltiazem (526 ng/ml).', select the correct biomedical concept for each mention using the provided options. In the answer, list the correct options, one for each mention, s... | <Mentions>: [metoprolol; diltiazem]
<Options>: A: n-monodemethyldiltiazem, cis-(-)-isomer (aka n-monodemethyldiltiazem)
B: tetrazepam
C: dilazep
D: 4,5-methanoproline
E: 1,5-benzothiazepin-4(5h)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2s-cis)- (aka diltiazem)
F: 1-(isopropylamin... | [H; E] |
<Instruct>: Given the context 'Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism).', select the correct biomedical concep... | <Mentions>: [metoprolol; diltiazem; propafenone; sparteine]
<Options>: A: midafenone (aka nizofenone)
B: diltiazem
C: pirafen
D: 1-(2-methoxyphenoxy)-3-((1-methylethyl)amino)-2-propanol (aka moprolol)
E: d-sparteine (aka sparteine)
F: tetrazepam
G: n-monodemethyldiltiazem
H: sparlon (aka modafinil)
I: 3,5-methanoprolin... | [S; B; T; E] |
<Instruct>: Given the context 'Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism).', select the correct biomedical concep... | <Mentions>: [metoprolol; diltiazem; propafenone; sparteine]
<Options>: A: metoprolol cr xl (aka metoprolol)
B: alpha-hydroxymetoprolol
C: sparteine
D: tiamdipine
E: midafenone (aka nizofenone)
F: apo-propafenone (aka propafenone)
G: penicillamine cysteine (aka penicillamine cysteine disulfide)
H: sparan
I: deacme-dilti... | [A; N; F; C] |
<Instruct>: Given the context 'Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism).', select the correct biomedical concep... | <Mentions>: [metoprolol; diltiazem; propafenone; sparteine]
<Options>: A: metoprolol cr xl (aka metoprolol)
B: sparinaritin
C: 1-(isopropylamino)-3-((4-propenyl-2-methoxy)phenoxy)-2-propanol
D: tetrazepam
E: 3,5-methanoproline
F: s-aminopropylcysteine (aka aminopropylcysteine)
G: deacetyl n-monodesmethyl diltiazem
H: p... | [A; M; H; R] |
<Instruct>: Given the context 'Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism).', select the correct biomedical concep... | <Mentions>: [metoprolol; diltiazem; propafenone; sparteine]
<Options>: A: propafenone dimer
B: alpha-hydroxymetoprolol
C: metoprolol cr xl (aka metoprolol)
D: sparlon (aka modafinil)
E: penicillamine cysteine (aka penicillamine cysteine disulfide)
F: dilzem (aka diltiazem)
G: s-aminopropylcysteine (aka aminopropylcyste... | [C; F; H; T] |
<Instruct>: Given the context 'Three months later the patient was exposed to a single dose of metoprolol, diltiazem, propafenone (since he had received this drug in the past), and sparteine (as a probe for the debrisoquine/sparteine type polymorphism of oxidative drug metabolism).', select the correct biomedical concep... | <Mentions>: [debrisoquine; sparteine]
<Options>: A: dmoql (aka 3,12-dimethyloctahydroindol-(2,3-a)quinolizine)
B: dpodq cpd (aka 7-(n,n-dimethylpiperazinium)-7-oxo-8,8-dicyanoquinodimethane)
C: sparteine, (-)-isomer (aka sparteine)
D: sparan
E: dddq cpd (aka 5,5'-didodecylamino-4,4'-dihydroxy-3,3'-diazodiphenoquinone-(... | [G; C] |
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