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What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))", "braf transforming gene, related sequence 1 (mus musculus)", "braf35 (mus musculus)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis))", "braf (mus musculu...
Given the context 'BRAF35 contains a nonspecific DNA binding HMG domain and a kinesin-like coiled coil domain.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brca2 dna repair associated (homo sapiens)", "fad (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fad1 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fancd (homo sapiens) (brca2 dna...
[ "brca2, dna repair associated (drosophila melanogaster)", "brca2 (drosophila melanogaster)", "brca2, dna repair associated (gallus gallus)", "brca2 (gallus gallus)", "brca1 (homo sapiens)", "brca1/brca2-containing complex subunit 3 (homo sapiens)", "brca2 (mus musculus)", "brca2, dna repair associated...
Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (mus musculus)" ]
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))", "braf transforming gene, related sequence 1 (mus musculus)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laev...
Given the context 'Similar to BRCA2, BRAF35 mRNA expression levels in mouse embryos are highest in proliferating tissues with high mitotic index.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))", "braf transforming gene, related sequence 1 (mus musculus)", "braf35 (mus musculus)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis))", "braf (mus musculu...
Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brca2 dna repair associated (homo sapiens)", "fad (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fad1 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fancd (homo sapiens) (brca2 dna...
[ "brca2, dna repair associated (drosophila melanogaster)", "brca2 (drosophila melanogaster)", "brca2, dna repair associated (gallus gallus)", "brca2 (gallus gallus)", "brca1 (homo sapiens)", "brca1/brca2-containing complex subunit 3 (homo sapiens)", "brca2 (mus musculus)", "brca2, dna repair associated...
Given the context 'Strikingly, nuclear staining revealed a close association of BRAF35/BRCA2 complex with condensed chromatin coincident with histone H3 phosphorylation.', answer the user's query.
What is the biomedical concept corresponding to 'brca2'?
[ "brca2 (homo sapiens)", "brca2 dna repair associated (homo sapiens)", "fad (homo sapiens) (brca2 dna repair associated (homo sapiens))", "brcc2 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fad1 (homo sapiens) (brca2 dna repair associated (homo sapiens))", "fancd (homo sapiens) (brca2 dna...
[ "brca2, dna repair associated (drosophila melanogaster)", "brca2 (drosophila melanogaster)", "brca2, dna repair associated (gallus gallus)", "brca2 (gallus gallus)", "brca1 (homo sapiens)", "brca1/brca2-containing complex subunit 3 (homo sapiens)", "brca2 (mus musculus)", "brca2, dna repair associated...
Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', answer the user's query.
What is the biomedical concept corresponding to 'braf35'?
[ "braf35 (homo sapiens)", "braf25 (homo sapiens)" ]
[ "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase s homeolog (xenopus laevis))", "braf transforming gene, related sequence 1 (mus musculus)", "braf35 (mus musculus)", "braf1 (xenopus laevis) (b-raf proto-oncogene, serine/threonine kinase l homeolog (xenopus laevis))", "braf (mus musculu...
Given the context 'Importantly, antibody microinjection experiments suggest a role for BRCA2/BRAF35 complex in modulation of cell cycle progression.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6-2'?
[ "nkx6-2 (mus musculus)", "nkx6.2 (mus musculus)" ]
[ "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)", "nkx6-1 (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6.1 (homo sapiens)", "nkx6-3 (homo sapiens)", "nkx6.3 (homo sapiens)", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx...
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'gtx'?
[ "gtx (mus musculus)" ]
[ "gtx (drosophila melanogaster)", "gtx (homo sapiens)", "gt-1 (drosophila melanogaster)", "gtx (xenopus tropicalis)", "gt-4 (drosophila melanogaster)", "gt-3 (drosophila melanogaster)", "trihelix transcription factor gt-1 (glycine max)", "tgx (homo sapiens)", "gth1 (xenopus laevis) (glutathione s-tra...
Given the context 'Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors. Nkx6-2 (former Gtx) is a murine-homeobox-containing gene localized distally on Chromosome (Chr) 7.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'We now report on the cloning and characterization of the human homolog (NKX6B).', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6-2'?
[ "nkx6-2 (mus musculus)", "nkx6.2 (mus musculus)" ]
[ "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)", "nkx6-1 (homo sapiens)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6.1 (homo sapiens)", "nkx6-3 (homo sapiens)", "nkx6.3 (homo sapiens)", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx...
Given the context 'NKX6B is predicted to encode a polypeptide of 277 amino acids with 97% identity to mouse Nkx6-2.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'Northern blot experiments showed that NKX6B expression is tightly controlled in a tissue-specific fashion with the highest site of expression being the brain.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'Finally, using STS content mapping and RH analyis, we demonstrated that NKX6B maps to the 10q26, a region where frequent loss of heterozygosity has been observed in various malignant brain tumors.', answer the user's query.
What is the biomedical concept corresponding to 'nkx6b'?
[ "nkx6b (homo sapiens)", "nkx6-2 (homo sapiens)", "nkx6.2 (homo sapiens)" ]
[ "nkx6.2 (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", "nkx6 (drosophila melanogaster)", "nkx6a (homo sapiens)", "nkx6b (xenopus tropicalis)", "nkx6.2 (xenopus laevis) (nk6 homeobox 2 l homeolog (xenopus laevis))", "nkx6-2.s (xenopus laevis) (nk6 homeobox 2 s homeolog (xenopus laevis))", ...
Given the context 'These results may implicate NKX6B as a candidate tumor suppressor gene for brain tumors, particularly for oligodendrogliomas.', answer the user's query.
What is the biomedical concept corresponding to 'cd58'?
[ "cd58 (homo sapiens)", "cd58 molecule (homo sapiens)", "ag3 (homo sapiens) (cd58 molecule (homo sapiens))" ]
[ "cd51 (homo sapiens)", "cd52 (homo sapiens)", "cd55 (homo sapiens)", "cd52 molecule (homo sapiens)", "cd57 (homo sapiens)", "cd59 (homo sapiens)", "cd54 (homo sapiens)", "cd5 (homo sapiens)", "cd5 molecule (homo sapiens)", "cd59 molecule (cd59 blood group) (homo sapiens)" ]
Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'Endothelial cell costimulation of T cell activation through CD58-CD2 interactions involves lipid raft aggregation. ', answer the user's query.
What is the biomedical concept corresponding to 'cd4'?
[ "cd4 (homo sapiens)", "cd4 molecule (homo sapiens)", "cd4mut (homo sapiens)" ]
[ "cd4 (mus musculus)", "cd4 molecule (gallus gallus)", "cd4 (sus scrofa) (loc494465 (sus scrofa))", "cd4 (gallus gallus)", "cd4 (sus scrofa) (cd4 molecule (sus scrofa))", "cd4 antigen (mus musculus)", "orphan cd4 (drosophila melanogaster)", "cd4 (bos taurus)", "integrin subunit alpha 4 (homo sapiens)...
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'cd58'?
[ "cd58 (homo sapiens)", "cd58 molecule (homo sapiens)", "ag3 (homo sapiens) (cd58 molecule (homo sapiens))" ]
[ "cd51 (homo sapiens)", "cd52 (homo sapiens)", "cd55 (homo sapiens)", "cd52 molecule (homo sapiens)", "cd57 (homo sapiens)", "cd59 (homo sapiens)", "cd54 (homo sapiens)", "cd5 (homo sapiens)", "cd5 molecule (homo sapiens)", "cd59 molecule (cd59 blood group) (homo sapiens)" ]
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'Human endothelial cells (EC) costimulate CD4(+) memory T cell activation through CD58-CD2 interactions.', answer the user's query.
What is the biomedical concept corresponding to 'fos'?
[ "fos (homo sapiens)", "fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "c-fos (homo sapiens)", "ap-1 (homo sapiens) (fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens))", "p55 (homo sapiens) (fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens))" ]
[ "fos (drosophila melanogaster)", "fos like 1, ap-1 transcription factor subunit (homo sapiens)", "c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis))", "c-fos (drosophila melanogaster)", "fos-like antigen 1 (mus musculus)", "fos like 2, ap-1 transcription fa...
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'jun'?
[ "jun (homo sapiens)", "c-jun (homo sapiens)", "jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "ap-1 (homo sapiens) (jun proto-oncogene, ap-1 transcription factor subunit (homo sapiens))" ]
[ "jun (drosophila melanogaster)", "jun proto-oncogene (mus musculus)", "d-jun (drosophila melanogaster)", "jun (xenopus laevis) (jun proto-oncogene s homeolog (xenopus laevis))", "jun proto-oncogene, opposite strand (mus musculus)", "jun (xenopus laevis) (jun proto-oncogene l homeolog (xenopus laevis))", ...
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'il-2'?
[ "interleukin 2 (homo sapiens)", "il-2 (homo sapiens)", "il2 (homo sapiens)" ]
[ "il22 (homo sapiens)", "interleukin 3 (homo sapiens)", "interleukin-2 (gallus gallus)", "interleukin 2 (rattus norvegicus)", "il-3 (homo sapiens)", "interleukin 2 (mus musculus)", "il-2 (mus musculus)", "il27 (homo sapiens) (myeloid derived growth factor (homo sapiens))", "colony stimulating factor ...
Given the context 'AP-1, composed of fos and jun proteins, is a critical effector of TCR signaling and binds several sites in the IL-2 promoter.', answer the user's query.
What is the biomedical concept corresponding to 'c-fos'?
[ "c-fos (homo sapiens)", "fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens)", "fos (homo sapiens)", "ap-1 (homo sapiens) (fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens))", "p55 (homo sapiens) (fos proto-oncogene, ap-1 transcription factor subunit (homo sapiens))" ]
[ "c-fos (drosophila melanogaster)", "c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog s homeolog (xenopus laevis))", "c-fos (mus musculus)", "c-fos (xenopus laevis) (fbj murine osteosarcoma viral oncogene homolog l homeolog (xenopus laevis))", "fos (drosophila melanogaster)", "c-fos p...
Given the context 'EC augment c-fos promoter activity in T cells; however, deletion analysis reveals no transcription factor binding sites in the promoter uniquely responsive to EC costimulation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', answer the user's query.
What is the biomedical concept corresponding to 'il-2'?
[ "interleukin 2 (homo sapiens)", "il-2 (homo sapiens)", "il2 (homo sapiens)" ]
[ "il22 (homo sapiens)", "interleukin 3 (homo sapiens)", "interleukin-2 (gallus gallus)", "interleukin 2 (rattus norvegicus)", "il-3 (homo sapiens)", "interleukin 2 (mus musculus)", "il-2 (mus musculus)", "il27 (homo sapiens) (myeloid derived growth factor (homo sapiens))", "colony stimulating factor ...
Given the context 'CD2 mAbs completely block EC effects on all of these pathways, as well as costimulation of IL-2 secretion.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'We conclude that EC costimulation through CD2 does not trigger a single distinct costimulatory pathway in T cells, but rather, it amplifies several pathways downstream of the TCR.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'Soluble CD2 mAbs block EC-induced raft aggregation, whereas cross-linking CD2 promotes aggregation.', answer the user's query.
What is the biomedical concept corresponding to 'cd2'?
[ "cd2 molecule (homo sapiens)", "cd2 (homo sapiens)", "srbc (homo sapiens) (cd2 molecule (homo sapiens))" ]
[ "cd2 (mus musculus) (cd2 antigen (mus musculus))", "cd22 (homo sapiens)", "cd21 (homo sapiens)", "cd22 molecule (homo sapiens)", "cd2 locus control region (homo sapiens)", "cd2ap (homo sapiens)", "cd23 (homo sapiens)", "cd2 antigen (mus musculus)", "t-cell surface antigen cd2-like (danio rerio)", ...
Given the context 'These data are consistent with the critical role of CD2 in organizing the T cell-APC contact zone.', answer the user's query.
What is the biomedical concept corresponding to 'mammalian target of rapamycin'?
[ "mechanistic target of rapamycin kinase (rattus norvegicus)" ]
[ "mechanistic target of rapamycin (drosophila melanogaster)", "target of rapamycin homolog (caenorhabditis elegans)", "mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mec...
Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. ', answer the user's query.
What is the biomedical concept corresponding to 'mtor'?
[ "mtor (rattus norvegicus)" ]
[ "mtor (homo sapiens)", "mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (drosophila melanogaster) (megator (drosophila melanogaster))", "tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (mus musculus)", "mt...
Given the context 'AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling. ', answer the user's query.
What is the biomedical concept corresponding to 'alpha1 ampk'?
[ "ampkalpha1 (rattus norvegicus)" ]
[ "ampk alpha 1 (homo sapiens)", "ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 1 (homo sapiens))", "ampka1 (homo sapiens)", "ampk (homo sapiens) (protein kinase amp-activated catalytic subunit alpha 2 (homo sapiens))", "ampk (drosophila melanogaster) (amp-activated protein kinase ...
Given the context 'The activity of alpha1 AMPK remained unchanged in gastrocnemius muscle from AICAR-treated animals compared with controls, whereas alpha2 AMPK activity was significantly increased (51%).', answer the user's query.
What is the biomedical concept corresponding to 'mammalian target of rapamycin'?
[ "mechanistic target of rapamycin kinase (rattus norvegicus)" ]
[ "mechanistic target of rapamycin (drosophila melanogaster)", "target of rapamycin homolog (caenorhabditis elegans)", "mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mec...
Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', answer the user's query.
What is the biomedical concept corresponding to 'mtor'?
[ "mtor (rattus norvegicus)" ]
[ "mtor (homo sapiens)", "mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (drosophila melanogaster) (megator (drosophila melanogaster))", "tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (mus musculus)", "mt...
Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', answer the user's query.
What is the biomedical concept corresponding to 'mtor'?
[ "mtor (rattus norvegicus)" ]
[ "mtor (homo sapiens)", "mtor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (drosophila melanogaster) (megator (drosophila melanogaster))", "tor (drosophila melanogaster) (mechanistic target of rapamycin (drosophila melanogaster))", "mtor (mus musculus)", "mt...
Given the context 'This depression was associated with decreased activation of protein kinases in the mammalian target of rapamycin (mTOR) signal transduction pathway as evidenced by reduced phosphorylation of protein kinase B on Ser(473), mTOR on Ser(2448), ribosomal protein S6 kinase on Thr(389), and eukaryotic initiation factor eIF4E-binding protein on Thr(37).', answer the user's query.
What is the biomedical concept corresponding to 'hmast205'?
[ "mast205 (homo sapiens)" ]
[ "mast205 (drosophila melanogaster)", "tmem205 (sus scrofa)", "mast 205 (drosophila melanogaster)", "tmem205 (mus musculus)", "tmem205 (homo sapiens)", "tmem205 (bos taurus)", "mast205 (mus musculus)", "fam205a (sus scrofa)", "ygr205w (saccharomyces cerevisiae s288c)", "tmem205 (xenopus tropicalis)...
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'microtubule-associated serine/threonine kinase-205 kda'?
[ "microtubule associated serine/threonine kinase 2 (homo sapiens)", "mast205 (homo sapiens)" ]
[ "microtubule-associated protein 205 (drosophila melanogaster)", "205-kda map (drosophila melanogaster)", "microtubule associated serine/threonine kinase 1 (homo sapiens)", "205kda map (drosophila melanogaster)", "205k map (drosophila melanogaster)", "microtubule associated serine/threonine kinase 3 (homo ...
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'hmast205'?
[ "mast205 (homo sapiens)" ]
[ "mast205 (drosophila melanogaster)", "tmem205 (sus scrofa)", "mast 205 (drosophila melanogaster)", "tmem205 (mus musculus)", "tmem205 (homo sapiens)", "tmem205 (bos taurus)", "mast205 (mus musculus)", "fam205a (sus scrofa)", "ygr205w (saccharomyces cerevisiae s288c)", "tmem205 (xenopus tropicalis)...
Given the context 'In addition, we identified a protein, hMAST205 (microtubule-associated serine/threonine kinase-205 kDa), which interacted with Protocadherin LKC; the interaction occurring between the PDZ domain of hMAST205 and C-terminal tail of Protocadherin LKC.', answer the user's query.
What is the biomedical concept corresponding to 'daxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (drosophila melanogaster)", "daxx-like protein (drosophila melanogaster)", "daxx (xenopus laevis)", "daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans)", "daxin (drosophila melanogaster)", "dax-1 (homo sapiens)", "daxx.l (xenopus laevis)", "dlp (drosophila melano...
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 2 (mus musculus)", "histone deacetylase 3 (homo sapiens)", "hdac (drosophila melanogaster) (histone deacetylase 1 (drosophila melanogaster))", "histone deacetylase 1 (drosophila melanogaster)", "histone deacetylase 4 (homo sapiens)", "hdac (dr...
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'chromatin-associated protein dek'?
[ "dek (homo sapiens)", "dek proto-oncogene (homo sapiens)" ]
[ "dek7 (drosophila melanogaster)", "dek domain-containing chromatin associated protein (arabidopsis thaliana) (dek-domain containing protein 3 (arabidopsis thaliana))", "dek proto-oncogene (mus musculus)", "dek proto-oncogene l homeolog (xenopus laevis)", "dek (drosophila melanogaster) (eph receptor tyrosine...
Given the context 'Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. ', answer the user's query.
What is the biomedical concept corresponding to 'daxx'?
[ "daxx (homo sapiens)" ]
[ "daxx (drosophila melanogaster)", "daxx-like protein (drosophila melanogaster)", "daxx (xenopus laevis)", "daxx;spx domain-containing protein;uncharacterized protein (caenorhabditis elegans)", "daxin (drosophila melanogaster)", "dax-1 (homo sapiens)", "daxx.l (xenopus laevis)", "dlp (drosophila melano...
Given the context 'Human Daxx is a protein that functions, in part, as a transcriptional co-repressor through its interaction with a growing number of nuclear, DNA-associated proteins.', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 2 (mus musculus)", "histone deacetylase 3 (homo sapiens)", "hdac (drosophila melanogaster) (histone deacetylase 1 (drosophila melanogaster))", "histone deacetylase 1 (drosophila melanogaster)", "histone deacetylase 4 (homo sapiens)", "hdac (dr...
Given the context 'Using co-fractionation and co-immunoprecipitation we demonstrate that hDaxx associates with proteins that are critical for transcriptional repression, such as histone deacetylase II, constituents of chromatin such as core histones H2A, H2B, H3 and H4, and Dek, a chromatin-associated protein reported to change the topology of DNA in chromatin in vitro.', answer the user's query.
What is the biomedical concept corresponding to 'histone deacetylase ii'?
[ "histone deacetylase 2 (homo sapiens)" ]
[ "histone deacetylase 1 (homo sapiens)", "histone deacetylase 2 (mus musculus)", "histone deacetylase 3 (homo sapiens)", "hdac (drosophila melanogaster) (histone deacetylase 1 (drosophila melanogaster))", "histone deacetylase 1 (drosophila melanogaster)", "histone deacetylase 4 (homo sapiens)", "hdac (dr...
Given the context 'We also demonstrate a requirement for the SPT domain and the first paired amphipathic helix of hDaxx for its association with histone deacetylase II and acetylated histone H4, respectively.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Regulation of human separase by securin binding and autocleavage. ', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Regulation of human separase by securin binding and autocleavage. ', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'BACKGROUND: Sister chromatid separation is initiated by separase, a protease that cleaves cohesin and thereby dissolves sister chromatid cohesion.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Separase is activated by the degradation of its inhibitor securin and by the removal of inhibitory phosphates.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'In human cells, separase activation also coincides with the cleavage of separase, but it is not known if this reaction activates separase, which protease cleaves separase, and how separase cleavage is regulated.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Inhibition of separase expression in human cells by RNA interference causes the formation of polyploid cells with large lobed nuclei.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Inhibitor binding experiments in vitro reveal that securin prevents the access of substrate analogs to the active site of separase.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Upon securin degradation, the active site of full-length separase becomes accessible, allowing rapid autocatalytic cleavage of separase at one of three sites.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'The resulting N- and C-terminal fragments remain associated and can be reinhibited by securin.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'A noncleavable separase mutant retains its ability to cleave cohesin in vitro.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Our results suggest that separase is required for sister chromatid separation during mitosis in human cells.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Our data further indicate that securin inhibits separase by blocking the access of substrates to the active site of separase.', answer the user's query.
What is the biomedical concept corresponding to 'securin'?
[ "pttg1 regulator of sister chromatid separation, securin (homo sapiens)" ]
[ "securin (caenorhabditis elegans)", "securin-like protein (caenorhabditis elegans)", "securin (xenopus laevis)", "provisional ortholog of pttg1 regulator of sister chromatid separation, securin (xenopus tropicalis)", "securin (saccharomyces cerevisiae s288c)", "sec-c motif-containing protein (caenorhabdit...
Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', answer the user's query.
What is the biomedical concept corresponding to 'separase'?
[ "extra spindle pole bodies like 1, separase (homo sapiens)", "esp1 (homo sapiens) (extra spindle pole bodies like 1, separase (homo sapiens))" ]
[ "separase (drosophila melanogaster)", "homolog of separase (arabidopsis thaliana)", "separase (caenorhabditis elegans) (cele_c13e3.1 (caenorhabditis elegans))", "separase (saccharomyces cerevisiae s288c)", "separase (arabidopsis thaliana) (extra spindle poles (arabidopsis thaliana))", "separase (caenorhab...
Given the context 'Securin proteolysis allows autocatalytic processing of separase into a cleaved form, but separase cleavage is not essential for separase activation.', answer the user's query.
What is the biomedical concept corresponding to 'cd3 gamma'?
[ "cd3 gamma subunit of t-cell receptor complex (homo sapiens)", "cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens))", "cd3-gammaamma (homo sapiens)" ]
[ "cd3 antigen, gamma polypeptide (mus musculus)", "cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens))", "cd3epsilon (homo sapiens)", "cd3 (mus musculus) (cd3 antigen, epsilon polypeptide (mus musculus))", "cd3e (homo sapiens)", "cd3h (homo sapiens)", "cd3g (mus musculus)", "...
Given the context 'Contribution of CD3 gamma to TCR regulation and signaling in human mature T lymphocytes. ', answer the user's query.
What is the biomedical concept corresponding to 'cd3 gamma'?
[ "cd3 gamma subunit of t-cell receptor complex (homo sapiens)", "cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens))", "cd3-gammaamma (homo sapiens)" ]
[ "cd3 antigen, gamma polypeptide (mus musculus)", "cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens))", "cd3epsilon (homo sapiens)", "cd3 (mus musculus) (cd3 antigen, epsilon polypeptide (mus musculus))", "cd3e (homo sapiens)", "cd3h (homo sapiens)", "cd3g (mus musculus)", "...
Given the context 'We report here on the participation of CD3 gamma in the activation and effector function of human mature T lymphocytes at the antigen recognition checkpoint.', answer the user's query.
What is the biomedical concept corresponding to 'cd3 gamma'?
[ "cd3 gamma subunit of t-cell receptor complex (homo sapiens)", "cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens))", "cd3-gammaamma (homo sapiens)" ]
[ "cd3 antigen, gamma polypeptide (mus musculus)", "cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens))", "cd3epsilon (homo sapiens)", "cd3 (mus musculus) (cd3 antigen, epsilon polypeptide (mus musculus))", "cd3e (homo sapiens)", "cd3h (homo sapiens)", "cd3g (mus musculus)", "...
Given the context 'Following TCR-CD3 engagement of human CD3 gamma-deficient T cell lines, and despite their lower TCR-CD3 surface levels compared to normal controls, mature T cell responses such as protein tyrosine phosphorylation and the regulation of expression of several cell surface molecules, including the TCR-CD3 itself, were either normal or only slightly affected.', answer the user's query.
What is the biomedical concept corresponding to 'icam-1'?
[ "icam1 (homo sapiens)", "intercellular adhesion molecule 1 (homo sapiens)" ]
[ "icam5 (homo sapiens)", "icam2 (homo sapiens)", "icam3 (homo sapiens)", "icam4 (homo sapiens)", "icam-r (homo sapiens)", "icam-5 (mus musculus)", "icam-1 (mus musculus)", "icam-4 (mus musculus)", "intercellular adhesion molecule 1, related sequence 1 (mus musculus)", "intercellular adhesion molecu...
Given the context 'In contrast, other physiological responses like the specific adhesion and concomitant cell polarization on ICAM-1-coated dishes were selectively defective, and activation-induced cell death was increased.', answer the user's query.
What is the biomedical concept corresponding to 'cd3 gamma'?
[ "cd3 gamma subunit of t-cell receptor complex (homo sapiens)", "cd3g (homo sapiens) (cd3 gamma subunit of t-cell receptor complex (homo sapiens))", "cd3-gammaamma (homo sapiens)" ]
[ "cd3 antigen, gamma polypeptide (mus musculus)", "cd3g (homo sapiens) (tcr gamma alternate reading frame protein (homo sapiens))", "cd3epsilon (homo sapiens)", "cd3 (mus musculus) (cd3 antigen, epsilon polypeptide (mus musculus))", "cd3e (homo sapiens)", "cd3h (homo sapiens)", "cd3g (mus musculus)", "...
Given the context 'Our data indicate that CD3 gamma contributes essential specialized signaling functions to certain mature T cell responses.', answer the user's query.
What is the biomedical concept corresponding to 'adam10'?
[ "adam10 (homo sapiens)", "adam metallopeptidase domain 10 (homo sapiens)", "ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens))" ]
[ "adam-ts10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian (drosophila melanogaster))", "adam30 (homo sapiens)", "adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian-like (drosophila melanogaster))", "adam3 (homo sapiens)", ...
Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. ', answer the user's query.
What is the biomedical concept corresponding to 'l1 adhesion molecule'?
[ "l1 cell adhesion molecule (homo sapiens)", "l1cam (homo sapiens)", "s10 (homo sapiens) (l1 cell adhesion molecule (homo sapiens))", "n-cam-l1 (homo sapiens)" ]
[ "l1 cell adhesion molecule (mus musculus)", "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 cell adhesion molecule (gallus gallus)", "l1 cell adhesion molecule (xenopus tropicalis)", "l1 cell adhesion molecule (rattus norvegicus)", "l1 cell adhesion molecule, paralog a (danio rerio)", ...
Given the context 'ADAM10-mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles. ', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'L1, an important molecule for cell migration of neural and tumor cells, is released by membrane-proximal cleavage, and soluble L1 promotes cell migration.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'Release of L1 is enhanced by shedding inducers such as phorbol ester and pervanadate, but it is also enhanced by depletion of cellular cholesterol with methyl-beta-cyclodextrin (MCD).', answer the user's query.
What is the biomedical concept corresponding to 'adam10'?
[ "adam10 (homo sapiens)", "adam metallopeptidase domain 10 (homo sapiens)", "ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens))" ]
[ "adam-ts10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian (drosophila melanogaster))", "adam30 (homo sapiens)", "adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian-like (drosophila melanogaster))", "adam3 (homo sapiens)", ...
Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'We show here that ADAM10 is involved in L1 cleavage, which occurs at the cell surface and in the Golgi apparatus.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', answer the user's query.
What is the biomedical concept corresponding to 'adam10'?
[ "adam10 (homo sapiens)", "adam metallopeptidase domain 10 (homo sapiens)", "ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens))" ]
[ "adam-ts10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian (drosophila melanogaster))", "adam30 (homo sapiens)", "adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian-like (drosophila melanogaster))", "adam3 (homo sapiens)", ...
Given the context 'MCD and pervanadate treatment induced the release of microvesicles containing full-length L1 and the active form of ADAM10.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'L1 cleavage occurred in isolated vesicles.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'L1-containing microvesicles could trigger haptotactic cell migration.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'Only the neural L1 form carrying the RSLE signal for clathrin-dependent endocytosis was recruited and cleaved in vesicles.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'Phorbol ester treatment activated L1 cleavage predominantly at the cell surface.', answer the user's query.
What is the biomedical concept corresponding to 'l1'?
[ "l1 cell adhesion molecule (homo sapiens)" ]
[ "l1 (mus musculus) (l1 cell adhesion molecule (mus musculus))", "l1 (drosophila melanogaster) (retroactive (drosophila melanogaster))", "l1 (drosophila melanogaster) (lethal (1) l1 (drosophila melanogaster))", "l1-r (homo sapiens)", "l1 repeat, a subfamily, member 1 (mus musculus)", "l1 cell adhesion mole...
Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', answer the user's query.
What is the biomedical concept corresponding to 'adam10'?
[ "adam10 (homo sapiens)", "adam metallopeptidase domain 10 (homo sapiens)", "ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens))" ]
[ "adam-ts10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian (drosophila melanogaster))", "adam30 (homo sapiens)", "adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian-like (drosophila melanogaster))", "adam3 (homo sapiens)", ...
Given the context 'Our results provide evidence for two pathways of L1 cleavage, based on ADAM10 localization, that can be activated differentially: 1) direct cleavage at the cell surface, and 2) release and cleavage in secretory vesicles most likely derived from the Golgi apparatus.', answer the user's query.
What is the biomedical concept corresponding to 'adam10'?
[ "adam10 (homo sapiens)", "adam metallopeptidase domain 10 (homo sapiens)", "ad10 (homo sapiens) (adam metallopeptidase domain 10 (homo sapiens))" ]
[ "adam-ts10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian (drosophila melanogaster))", "adam30 (homo sapiens)", "adam metallopeptidase with thrombospondin type 1 motif 10 (homo sapiens)", "adam10 (drosophila melanogaster) (kuzbanian-like (drosophila melanogaster))", "adam3 (homo sapiens)", ...
Given the context 'The findings establish a novel role for ADAM10 as a vesicle-based protease.', answer the user's query.
What is the biomedical concept corresponding to 'yaf2'?
[ "yaf2 (homo sapiens)" ]
[ "yaf1 (homo sapiens)", "yaf2-b (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis))", "yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis))", "yaf2-a (xenopus laevis) (yy1 associated factor 2 l homeolog (xenopus laevis))", "yaf2-b (xenopus laevis) (yy1 associated f...
Given the context 'Yaf2 inhibits Myc biological function. ', answer the user's query.
What is the biomedical concept corresponding to 'myc'?
[ "myc proto-oncogene, bhlh transcription factor (homo sapiens)", "myc (homo sapiens)", "c-myc (homo sapiens)" ]
[ "myc (drosophila melanogaster)", "myc (mus musculus) (myelocytomatosis oncogene (mus musculus))", "c-myc (drosophila melanogaster)", "v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus)", "l-myc (homo sapiens)", "d-myc (drosophila melanogaster)", "mycl proto-oncogene, bhlh transcription ...
Given the context 'Yaf2 inhibits Myc biological function. ', answer the user's query.
What is the biomedical concept corresponding to 'myc'?
[ "myc proto-oncogene, bhlh transcription factor (homo sapiens)", "myc (homo sapiens)", "c-myc (homo sapiens)" ]
[ "myc (drosophila melanogaster)", "myc (mus musculus) (myelocytomatosis oncogene (mus musculus))", "c-myc (drosophila melanogaster)", "v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus)", "l-myc (homo sapiens)", "d-myc (drosophila melanogaster)", "mycl proto-oncogene, bhlh transcription ...
Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', answer the user's query.
What is the biomedical concept corresponding to 'mycn'?
[ "mycn proto-oncogene, bhlh transcription factor (homo sapiens)", "mycn (homo sapiens)" ]
[ "mycn (xenopus laevis) (mycn proto-oncogene, bhlh transcription factor s homeolog (xenopus laevis))", "mycn (xenopus laevis) (mycn proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis))", "mycn proto-oncogene, bhlh transcription factor (xenopus tropicalis)", "mycn, opposite strand (mus musculu...
Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', answer the user's query.
What is the biomedical concept corresponding to 'mycl'?
[ "mycl proto-oncogene, bhlh transcription factor (homo sapiens)", "mycl (homo sapiens)", "l-myc (homo sapiens)", "bhlhe38 (homo sapiens) (mycl proto-oncogene, bhlh transcription factor (homo sapiens))" ]
[ "myc (drosophila melanogaster)", "myc (xenopus laevis) (myc proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis))", "myc (homo sapiens)", "l-myc (xenopus laevis) (mycl proto-oncogene, bhlh transcription factor l homeolog (xenopus laevis))", "v-myc avian myelocytomatosis viral oncogene lung ...
Given the context 'The proto-oncogenes of the myelocytomatosis viral oncogene homolog (MYC) family, including MYC, MYCN and MYCL, encode nuclear proteins that act as transcription factors.', answer the user's query.
What is the biomedical concept corresponding to 'myc'?
[ "myc proto-oncogene, bhlh transcription factor (homo sapiens)", "myc (homo sapiens)", "c-myc (homo sapiens)" ]
[ "myc (drosophila melanogaster)", "myc (mus musculus) (myelocytomatosis oncogene (mus musculus))", "c-myc (drosophila melanogaster)", "v-myc avian myelocytomatosis viral oncogene homolog (gallus gallus)", "l-myc (homo sapiens)", "d-myc (drosophila melanogaster)", "mycl proto-oncogene, bhlh transcription ...
Given the context 'The Myc protein is the best studied member of this family and is involved in cell cycle regulation, differentiation and cell death.', answer the user's query.
What is the biomedical concept corresponding to 'yaf2'?
[ "yaf2 (homo sapiens)" ]
[ "yaf1 (homo sapiens)", "yaf2-b (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis))", "yaf2-a (xenopus laevis) (yy1 associated factor 2 s homeolog (xenopus laevis))", "yaf2-a (xenopus laevis) (yy1 associated factor 2 l homeolog (xenopus laevis))", "yaf2-b (xenopus laevis) (yy1 associated f...
Given the context 'We have previously demonstrated that the zinc-finger protein Yaf2 interacts with the central region of MycN and enhances MycN dependent transcriptional activation.', answer the user's query.