instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'It has a RING finger motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp).', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
B: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
C: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase 2)
D: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1... | F |
<Instruct>: Given the context 'efp cDNA contains a consensus estrogen-responsive element at the 3' untranslated region that can act as a downstream estrogen-dependent enhancer.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efp (rattus norvegicus) (aka tripartite motif-containing 25)
B: efp (homo sapiens) (aka tripartite motif containing 25)
C: efp (escherichia coli str. k-12 substr. mg1655) (aka protein chain elongation factor ef-p)
D: efo2p (homo sapiens) (aka establishment of sister chromatid cohesion n-acetyltransferase ... | B |
<Instruct>: Given the context 'Moreover, efp is regulated by estrogen as demonstrated at both the mRNA and the protein level in ER-positive cells derived from mammary gland.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efp (homo sapiens) (aka tripartite motif containing 25)
B: epf (homo sapiens) (aka heat shock protein family e (hsp10) member 1)
C: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
D: efc (homo sapiens) (aka regulatory factor x1)
E: efo2p (homo sapiens) (aka establishment of sister chromatid coh... | A |
<Instruct>: Given the context 'These data suggest that efp may represent an estrogen-responsive transcription factor that mediates phenotypic expression of the diverse estrogen action.', select the correct biomedical concept corresponding to 'efp'. Answer using one of the provided options. | <Options>: A: efe (homo sapiens) (aka tafazzin, phospholipid-lysophospholipid transacylase)
B: efp (rattus norvegicus) (aka tripartite motif-containing 25)
C: efp (homo sapiens) (aka tripartite motif containing 25)
D: efp1 (homo sapiens) (aka thioredoxin domain containing 11)
E: efo2p (homo sapiens) (aka establishment ... | C |
<Instruct>: Given the context 'A human mitochondrial ATP-dependent protease that is highly homologous to bacterial Lon protease.
', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lonpl (homo sapiens) (aka lon peptidase 2, peroxisomal)
B: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
C: lon peptidase 1, mitochondrial (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon protease (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E... | D |
<Instruct>: Given the context 'A single species of mRNA was found for this Lon protease in all human tissues examined.', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
B: lon protease (drosophila melanogaster) (aka lon protease)
C: lonp1 (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E: lonpl (homo sapiens) (aka lon ... | C |
<Instruct>: Given the context 'Immunofluorescence microscopy suggested a predominantly mitochondrial localization for the Lon protease in cultured human cells.', select the correct biomedical concept corresponding to 'lon protease'. Answer using one of the provided options. | <Options>: A: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
B: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
C: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon protease (drosophila melanogaster) (aka lon protease)... | C |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correc... | <Options>: A: lon protease homolog, mitochondrial (caenorhabditis elegans) (aka lon protease homolog, mitochondrial)
B: lon peptidase 1, mitochondrial (homo sapiens) (aka lon peptidase 1, mitochondrial)
C: lon protease (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
D: lon-1 (caenorhabditis elegans) (aka... | C |
<Instruct>: Given the context 'A truncated LON gene, in which translation was initiated at Met118 of the coding sequence, was expressed in Escherichia coli and produced a protease that degraded alpha-casein in vitro in an ATP-dependent manner and had other properties similar to E. coli Lon protease.', select the correc... | <Options>: A: lon-1 (caenorhabditis elegans) (aka protein lon-1;scp domain-containing protein)
B: lon protease (drosophila melanogaster) (aka lon protease)
C: lon (homo sapiens) (aka lon peptidase 1, mitochondrial)
D: lon (escherichia coli str. k-12 substr. mg1655) (aka lon protease)
E: lonpl (homo sapiens) (aka lon pe... | D |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'beta/a4-protein'. Answer using one of the provided options. | <Options>: A: beta-4 (homo sapiens) (adaptor related protein complex 4 subunit beta 1 (homo sapiens)) (aka adaptor related protein complex 4 subunit beta 1)
B: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
C: vac-beta (homo sapiens) (aka annexin a8 like 1)
D: calcium voltage-gated channel au... | F |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: actr1b (homo sapiens) (aka actin related protein 1b)
B: arpn-beta (homo sapiens) (aka actin like 6a)
C: adra1b (homo sapiens) (aka adrenoceptor alpha 1b)
D: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
E: actin beta (homo sapiens) (aka actin beta)
F: None of the above. | F |
<Instruct>: Given the context 'We analyzed the entire amino acid sequences in an amyloid preparation and found, in addition to the major beta/A4-protein (A beta) fragment, two unknown peptides.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
B: actr1b (homo sapiens) (aka actin related protein 1b)
C: accbeta (homo sapiens) (aka acetyl-coa carboxylase beta)
D: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
E: adra1b (homo sapiens) (aka adrenoceptor a... | F |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nascent polype... | B |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'non-a beta component of ad amyloid'. Answer using one of the provided options. | <Options>: A: adnp (homo sapiens) (aka activity dependent neuroprotector homeobox)
B: snca (homo sapiens) (aka synuclein alpha)
C: alzheimer disease 7 (homo sapiens) (aka alzheimer disease 7)
D: synuclein beta (homo sapiens) (aka synuclein beta)
E: adn (homo sapiens) (aka complement factor d)
F: None of the above. | B |
<Instruct>: Given the context 'We tentatively named this 35-amino acid peptide NAC (non-A beta component of AD amyloid) and its precursor NACP.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
B: nacp (homo sapiens) (aka synuclein alpha)
C: nac (drosophila melanogaster) (nascent polypeptide associated complex protein alpha subunit (drosophila melanogaster)) (aka nascent polypeptide... | B |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
B: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
C: nac (escherichia coli str. k-12 substr. mg1655) (aka dna-binding transcriptional dual regulator nac)
D: nacp (homo sapiens) (aka synuclein alpha)
E: ... | D |
<Instruct>: Given the context 'NAC is the second component, after A beta, identified chemically in the purified AD amyloid preparation.', select the correct biomedical concept corresponding to 'a beta'. Answer using one of the provided options. | <Options>: A: actin beta (homo sapiens) (aka actin beta)
B: acc-beta (homo sapiens) (aka acetyl-coa carboxylase beta)
C: cg-beta-a (homo sapiens) (aka chorionic gonadotropin subunit beta 7)
D: arpn-beta (homo sapiens) (aka actin like 6a)
E: a-beta (homo sapiens) (aka succinate-coa ligase adp-forming subunit beta)
F: No... | F |
<Instruct>: Given the context 'Secondary structure predictions indicate that the NAC peptide sequence has a strong tendency to form beta-structures consistent with its association with amyloid.', select the correct biomedical concept corresponding to 'nac'. Answer using one of the provided options. | <Options>: A: nacb (homo sapiens) (aka basic transcription factor 3)
B: nac (drosophila melanogaster) (neuronally altered carbohydrate (drosophila melanogaster)) (aka neuronally altered carbohydrate)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nacc1 (homo sapiens) (aka nucleus a... | E |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nacb (homo sapiens) (aka basic transcription factor 3)
B: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
C: nacp (homo sapiens) (aka synuclein alpha)
D: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
E: nacap1 (homo sapiens) (aka naca family member ... | C |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
B: nacp (homo sapiens) (aka synuclein alpha)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nac domain protein nac1 (glycine max) (aka nac domain ... | B |
<Instruct>: Given the context 'NACP is detected as a M(r) 19,000 protein in the cytosolic fraction of brain homogenates and comigrates on immunoblots with NACP synthesized in Escherichia coli from NACP cDNA.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
B: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
C: naca (homo sapiens) (aka nascent polypeptide associated complex subunit alpha)
D: nacb (homo sapiens) (aka basic transcription factor 3)
E: nacp (homo sapiens) (aka synuclein alpha)... | E |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided option... | <Options>: A: nac (drosophila melanogaster) (nascent polypeptide associated complex protein alpha subunit (drosophila melanogaster)) (aka nascent polypeptide associated complex protein alpha subunit)
B: nacc1 (homo sapiens) (aka nucleus accumbens associated 1)
C: naca (homo sapiens) (aka nascent polypeptide associated ... | D |
<Instruct>: Given the context 'NACP mRNA is expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver, suggesting its ubiquitous and brain-specific functions.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided option... | <Options>: A: nac domain protein nac1 (glycine max) (aka nac domain protein nac1)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: nascent polypeptide-associated complex nac (arabidopsis thaliana) (aka nascent polypeptide-associated complex nac)
D: nacap1 (homo sapiens) (aka naca family mem... | F |
<Instruct>: Given the context 'The availability of the cDNA encoding full-length NACP should help to elucidate the mechanisms of amyloidosis in AD.', select the correct biomedical concept corresponding to 'nacp'. Answer using one of the provided options. | <Options>: A: nacp (homo sapiens) (aka synuclein alpha)
B: nac1a (homo sapiens) (aka sodium voltage-gated channel alpha subunit 4)
C: nacap1 (homo sapiens) (aka naca family member 4, pseudogene)
D: nac-1 (homo sapiens) (aka nucleus accumbens associated 1)
E: nacb (homo sapiens) (aka basic transcription factor 3)
F: Non... | A |
<Instruct>: Given the context 'Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.
', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrf1 (homo sapiens) (nfe2 like bzip transcription factor 1 (homo sapiens)) (aka nfe2 like bzip transcription factor 1)
B: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
C: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff... | A |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept corresponding to '... | <Options>: A: nrf1 (homo sapiens) (nfe2 like bzip transcription factor 1 (homo sapiens)) (aka nfe2 like bzip transcription factor 1)
B: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
C: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
D: nrf1 (homo sapiens) (nuclear respirat... | A |
<Instruct>: Given the context 'We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1.', select the correct biomedical concept corresponding to '... | <Options>: A: nfe2 (homo sapiens) (aka nuclear factor, erythroid 2)
B: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
C: nuclear factor, erythroid derived 2,-like 1 (mus musculus) (aka nuclear factor, erythroid derived 2,-like 1)
D: nfe2l1_retired (rattus norvegicus) (aka nuclear respiratory factor 1)... | B |
<Instruct>: Given the context 'Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrf1 (homo sapiens) (nuclear respiratory factor 1 (homo sapiens)) (aka nuclear respiratory factor 1)
B: nrf1 (rattus norvegicus) (aka nuclear respiratory factor 1)
C: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
D: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit ... | E |
<Instruct>: Given the context 'Nrf1 activates transcription via NF-E2 binding sites in yeast cells.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the provided options. | <Options>: A: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
B: nrf2a (homo sapiens) (aka ga binding protein transcription factor subunit alpha)
C: nrf (homo sapiens) (aka nfkb repressing factor)
D: nrf-1 (homo sapiens) (aka nfe2 like bzip transc... | D |
<Instruct>: Given the context 'The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.', select the correct biomedical concept corresponding to 'nrf1'. Answer using one of the p... | <Options>: A: nrf-1 (homo sapiens) (aka nfe2 like bzip transcription factor 1)
B: nrf-1 (xenopus tropicalis) (aka nuclear respiratory factor 1)
C: nrf (homo sapiens) (aka nfkb repressing factor)
D: nrff (escherichia coli str. k-12 substr. mg1655) (aka putative formate-dependent nitrite reductase complex subunit nrff)
E... | A |
<Instruct>: Given the context 'Recessive mutations in the gene encoding the beta-subunit of rod phosphodiesterase in patients with retinitis pigmentosa.
', select the correct biomedical concept corresponding to 'beta-subunit of rod phosphodiesterase'. Answer using one of the provided options. | <Options>: A: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
B: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
C: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
D: pde3b (homo sapiens) (aka phosphodiesterase 3b)
E: phos... | B |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'beta-subuni... | <Options>: A: pdeb (homo sapiens) (aka phosphodiesterase 6b)
B: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
C: pde3b (homo sapiens) (aka phosphodiesterase 3b)
D: phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide (mus musculus) (aka phosphodiesterase 6b, cgmp, rod receptor, beta polypeptide)
... | A |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'pde beta'. ... | <Options>: A: pde6b (homo sapiens) (aka phosphodiesterase 6b)
B: pde8b (homo sapiens) (aka phosphodiesterase 8b)
C: pde1b (homo sapiens) (aka phosphodiesterase 1b)
D: pde7b (homo sapiens) (aka phosphodiesterase 7b)
E: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
F: None of the above. | A |
<Instruct>: Given the context 'We have found four mutations in the human gene encoding the beta-subunit of rod cGMP phosphodiesterase (PDE beta) that cosegregate with autosomal recessive retinitis pigmentosa, a degenerative disease of photoreceptors.', select the correct biomedical concept corresponding to 'pde beta'. ... | <Options>: A: pde8b (homo sapiens) (aka phosphodiesterase 8b)
B: pde7b (homo sapiens) (aka phosphodiesterase 7b)
C: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
D: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
E: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
F: None of the above. | F |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept correspondi... | <Options>: A: phosphodiesterase 1b (homo sapiens) (aka phosphodiesterase 1b)
B: pde8b (homo sapiens) (aka phosphodiesterase 8b)
C: phosphodiesterase 3b (homo sapiens) (aka phosphodiesterase 3b)
D: gmp-pdebeta (homo sapiens) (aka phosphodiesterase 6b)
E: pdeivb (homo sapiens) (aka phosphodiesterase 4b)
F: None of the ab... | D |
<Instruct>: Given the context 'PDE beta is the second member of the phototransduction cascade besides rhodopsin that is absent or altered as a cause of retinitis pigmentosa, suggesting that other members of this pathway may be defective in other forms of this disease.', select the correct biomedical concept correspondi... | <Options>: A: retinal pigment epithelium-derived rhodopsin homolog (homo sapiens) (aka retinal pigment epithelium-derived rhodopsin homolog)
B: rh (drosophila melanogaster) (rhodopsin 3 (drosophila melanogaster)) (aka rhodopsin 3)
C: rhodopsin-1 (drosophila melanogaster) (aka neither inactivation nor afterpotential e)
... | E |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided options. | <Options>: A: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
B: v-rel avian reticuloendotheliosis viral oncogene homolog b (xenopus tropicalis) (aka v-rel avian reticuloendotheliosis viral oncogene homolog b)
C: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (x... | A |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka ... | B |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the provided options. | <Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
D: nfkb-p... | B |
<Instruct>: Given the context 'Chromosomal localization of genes encoding the transcription factors, c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10 by fluorescence in situ hybridization.
', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provided options. | <Options>: A: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
C: interleukin 10 (homo sapiens) (aka interleukin 10)
D: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig dom... | A |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided... | <Options>: A: i-rel (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
B: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
C: v-rel avian reticuloendotheliosis viral oncogene homol... | E |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the ... | <Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: relb proto-oncogene, nf-kb subunit (homo sapiens) (aka relb proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
D: nf... | D |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the ... | <Options>: A: nf-kb2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: rela proto-oncogene, nf-kb subunit (homo sapiens) (aka rela proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
D: nf-kb (homo sapiens) (aka nuclea... | B |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provide... | <Options>: A: nkat-10 (homo sapiens) (aka killer cell immunoglobulin like receptor, three ig domains and short cytoplasmic tail 1)
B: interleukin 10 (homo sapiens) (aka interleukin 10)
C: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
D: lyt-10 (homo sapiens) (aka... | D |
<Instruct>: Given the context 'We have used fluorescence in situ hybridization (FISH) to perform precise chromosomal mapping of the genes encoding the transcription factors c-rel, NF-kappa Bp50, NF-kappa Bp65, and lyt-10.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provide... | <Options>: A: ilt10 (homo sapiens) (aka leukocyte immunoglobulin-like receptor pseudogene 2)
B: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
C: interleukin 1 family member 10 (homo sapiens) (aka interleukin 1 family member 10)
D: interleukin 10 (homo sapiens) (a... | F |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept corresponding to 'c-rel'. Answer using one of the provided options. | <Options>: A: c-rel (xenopus laevis) (v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog (xenopus laevis)) (aka v-rel avian reticuloendotheliosis viral oncogene homolog l homeolog)
B: c-rel (homo sapiens) (aka rel proto-oncogene, nf-kb subunit)
C: v-rel avian reticuloendotheliosis viral oncogene homolo... | B |
<Instruct>: Given the context 'The previously published assignments of c-rel and NF-kappa Bp50 have been refined to specific bands.', select the correct biomedical concept corresponding to 'nf-kappa bp50'. Answer using one of the provided options. | <Options>: A: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit pseudogene)
B: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
C: nf-kappab (homo sapiens) (aka nuclear factor kappa b subunit 1)
D: rela proto-oncogene, nf-kb subuni... | C |
<Instruct>: Given the context 'The map position of lyt-10, inferred from its isolation from a t(10;14)(q24;q32) translocation, has been confirmed.', select the correct biomedical concept corresponding to 'lyt-10'. Answer using one of the provided options. | <Options>: A: lyt-10 (xenopus tropicalis) (aka nuclear factor of kappa light polypeptide gene enhancer in b-cells 2)
B: tnf superfamily member 10 (homo sapiens) (aka tnf superfamily member 10)
C: lyt-10 (homo sapiens) (aka nuclear factor kappa b subunit 2)
D: interleukin 10 (homo sapiens) (aka interleukin 10)
E: nkat-1... | C |
<Instruct>: Given the context 'NF-kappa Bp65 has now been mapped to 11q13, a site of frequent involvement in aberration in multiple tumor types.', select the correct biomedical concept corresponding to 'nf-kappa bp65'. Answer using one of the provided options. | <Options>: A: nuclear factor kappa b subunit 2 (homo sapiens) (aka nuclear factor kappa b subunit 2)
B: p65 (homo sapiens) (rela proto-oncogene, nf-kb subunit (homo sapiens)) (aka rela proto-oncogene, nf-kb subunit)
C: rela proto-oncogene, nf-kb subunit pseudogene (homo sapiens) (aka rela proto-oncogene, nf-kb subunit ... | B |
<Instruct>: Given the context 'Cloning, sequencing and expression of a cDNA encoding mammalian valyl-tRNA synthetase.
', select the correct biomedical concept corresponding to 'valyl-trna synthetase'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
D: valyl-trna synthetase 1 ... | D |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept corresponding to 'valyl-trna synthetase'. Answer using one of the pr... | <Options>: A: valyl-trna synthetase (drosophila melanogaster) (aka valyl-trna synthetase)
B: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
C: valyl-trna synthetase 1 (xenopus tropicalis) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) ... | F |
<Instruct>: Given the context 'A fragment of the cDNA encoding a rat valyl-tRNA synthetase (TrsVal)-like protein was cloned from a rat cDNA library in lambda gt11 using an oligodeoxyribonucleotide (oligo) probe.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
C: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / v... | C |
<Instruct>: Given the context 'Three independent plaque clones containing the human TrsVal cDNA were then isolated from a lambda gt10 human erythroleukemia cDNA library using the rat cDNA fragment as the hybridization probe.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the prov... | <Options>: A: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
B: valine--trna ligase-like (gallus gallus) (aka valine--trna ligase-like)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (ak... | C |
<Instruct>: Given the context 'The deduced 1051-amino-acid sequence shares 65% identity with yeast TrsVal, and contains a highly basic N-terminal region, a newly evolved protease-sensitive region in sequence close to the C terminus, and several sites for protein kinase C phosphorylation.', select the correct biomedical... | <Options>: A: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
B: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
C: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase (valrs) (... | A |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (bos taurus) (aka valyl-trna synthetase 1)
B: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
C: valine--trna ligase (saccharomyces cerevisiae s288c) (aka valine--trna ligase)
D: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
E: valyl-trna synthetase ... | D |
<Instruct>: Given the context 'A 3-kb cDNA fragment was sub-cloned into plasmid pSVL and expressed in COS-7 cells; up to a sevenfold increase in TrsVal activity was obtained.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: trsval (rattus norvegicus) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase 2, mitochondrial (bos taurus) (aka valyl-trna synthetase 2, mitochondrial)
C: valyl-trna synthetase 1 (sus scrofa) (aka valyl-trna synthetase 1)
D: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (a... | F |
<Instruct>: Given the context 'These results confirm the cloning and sequencing of a human TrsVal-encoding cDNA.', select the correct biomedical concept corresponding to 'trsval'. Answer using one of the provided options. | <Options>: A: valyl-trna synthetase 1 (homo sapiens) (aka valyl-trna synthetase 1)
B: valyl-trna synthetase / valine-trna ligase (valrs) (arabidopsis thaliana) (aka valyl-trna synthetase / valine-trna ligase (valrs))
C: valyl-trna synthetase / valine-trna ligase-like protein (arabidopsis thaliana) (aka valyl-trna synth... | A |
<Instruct>: Given the context 'Localization of the intronless gene coding for calmodulin-like protein CLP to human chromosome 10p13-ter.
', select the correct biomedical concept corresponding to 'calmodulin-like protein clp'. Answer using one of the provided options. | <Options>: A: calmodulin like 5 (homo sapiens) (aka calmodulin like 5)
B: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
C: calponin-like proteins (caenorhabditis elegans) (aka calponin-like proteins)
D: calmodulin-like protein (arabidopsis thaliana) (aka calmodulin-like protein)
E: calmodulin like 6 (homo sa... | B |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept corresponding to 'calmodulin-like protein'. Answer using one of the provided options. | <Options>: A: calmodulin like 6 (homo sapiens) (aka calmodulin like 6)
B: calmodulin-like (glycine max) (aka calmodulin-like)
C: calmodulin like 3 (homo sapiens) (aka calmodulin like 3)
D: calmodulin-like 3 (mus musculus) (aka calmodulin-like 3)
E: camk-like (drosophila melanogaster) (aka uncharacterized protein)
F: No... | C |
<Instruct>: Given the context 'The functional intronless gene coding for a calmodulin-like protein (CLP) has been localized to human chromosome 10p13-ter.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clpa (homo sapiens) (aka t-box transcription factor 22)
B: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
C: clps (homo sapiens) (aka colipase)
D: clpp (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
E: clpp (oryctolagus cuniculus) (aka casei... | F |
<Instruct>: Given the context 'Chromosomal assignment was performed by Southern blot analysis of DNA from human-rodent somatic cell hybrids and amplification of a CLP gene-specific 1090-bp DNA fragment by the polymerase chain reaction (PCR) on DNA from human-hamster cell hybrids.', select the correct biomedical concept... | <Options>: A: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
B: clpa (homo sapiens) (aka t-box transcription factor 22)
C: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
D: clpp (homo sapiens) (aka caseinolytic mitochondria... | F |
<Instruct>: Given the context 'The CLP gene is the first member of the human calmodulin/calmodulin-like gene family to be chromosomally sublocalized.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clp-1 (homo sapiens) (aka cyclin and cbs domain divalent metal cation transport mediator 1)
B: clpx (homo sapiens) (aka caseinolytic mitochondrial matrix peptidase chaperone subunit x)
C: clps (oryctolagus cuniculus) (aka colipase)
D: clph (homo sapiens) (aka calcium binding protein, spermatid associated ... | F |
<Instruct>: Given the context 'The generation of a human CLP gene-specific sequence tag site specified by the two primers used for PCR should prove useful for future linkage studies.', select the correct biomedical concept corresponding to 'clp'. Answer using one of the provided options. | <Options>: A: clph (homo sapiens) (aka calcium binding protein, spermatid associated 1)
B: clpp (oryctolagus cuniculus) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit)
C: clpp (xenopus laevis) (aka caseinolytic mitochondrial matrix peptidase proteolytic subunit l homeolog)
D: clpa (homo sapiens) (... | F |
<Instruct>: Given the context 'A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes.', select the correct biomedical concept corresponding to 'cytochrome p-450 family 4'. Answer using one of the provided options. | <Options>: A: cytochrome p450 family 3 subfamily a member 4 (homo sapiens) (aka cytochrome p450 family 3 subfamily a member 4)
B: cytochrome p450, family 4, subfamily f, polypeptide 4 (rattus norvegicus) (aka cytochrome p450, family 4, subfamily f, polypeptide 4)
C: cytochrome p450 family 4 subfamily f member 8 (homo s... | D |
<Instruct>: Given the context 'cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
', select the correct biomedical concept corresponding to 'leukotriene b4 omega-hydroxylase'. Answer using one of the provided options. | <Options>: A: leukotriene-b(4) omega-hydroxylase 2-like (bos taurus) (aka leukotriene-b(4) omega-hydroxylase 2-like)
B: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
C: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
D: leukotriene a-4 hydrolase-like (glycine max) (aka leukotriene a-4 h... | C |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept corresponding to 'leukotriene b4 (ltb4) omega-hydroxylase'. Answer using one ... | <Options>: A: leukotriene a4 hydrolase (homo sapiens) (aka leukotriene a4 hydrolase)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: leukotriene a-4 hydrolase-like (glycine max) (aka leukotriene a-4 hydrolase-like)
D: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamil... | B |
<Instruct>: Given the context 'Isolation of cDNA clones for human leukotriene B4 (LTB4) omega-hydroxylase clearly demonstrates that the hydroxylase is a member of the cytochrome P-450 (CYP) superfamily.', select the correct biomedical concept corresponding to 'leukotriene b4 (ltb4) omega-hydroxylase'. Answer using one ... | <Options>: A: arachidonate 5-lipoxygenase (homo sapiens) (aka arachidonate 5-lipoxygenase)
B: lox4 (glycine max) (aka lipoxygenase)
C: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
D: cyp2b4 (oryctolagus cuniculus) (aka cytochrome p450, family 2, subfamily b, polypeptide 4)
E: leukotriene a-4 hydrolase-like (gl... | F |
<Instruct>: Given the context 'The microsomes from yeast cells transfected with an expression vector pAAH5 carrying isolated cDNA catalyzed the omega-hydroxylation of LTB4 with a Km value of 0.71 microM, and its activity was significantly inhibited by carbon monoxide and by antisera against CYP4A4, consistent with the ... | <Options>: A: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
B: cytochrome p450 2b4-like (xenopus tropicalis) (aka cytochrome p450 2b4-like)
C: arachidonate 15-lipoxygenase type b (homo sapiens) (aka arachidonate 15-lipoxygenase type b)
D: leukotriene a4 hydrolase (homo sapiens) (aka leukotriene a4 hydrolase)
E:... | E |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept corresponding to 'ltb4 omega-hydroxyl... | <Options>: A: arachidonate 5-lipoxygenase (homo sapiens) (aka arachidonate 5-lipoxygenase)
B: ltb4dh (homo sapiens) (aka prostaglandin reductase 1)
C: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
D: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
E: cyp2b4 (oryctolagus cunicul... | C |
<Instruct>: Given the context 'The amino acid sequence of LTB4 omega-hydroxylase (P-450LTB omega) shows 31-44% similarity to those of CYP4A, CYP4B, and CYP4C, whereas less than 25% similarity was observed with any of the other P-450 families.', select the correct biomedical concept corresponding to 'p-450ltb omega'. An... | <Options>: A: ltb4dh (oryctolagus cuniculus) (aka prostaglandin reductase 1)
B: cyp2e (oryctolagus cuniculus) (aka cytochrome p450 2e1)
C: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
D: cytochrome p450 lm4 (oryctolagus cuniculus) (aka cytochrome p450 lm4)
E: cytochrome p450 2b4-like (xenopu... | C |
<Instruct>: Given the context 'According to the systematic classification of the P-450 superfamily, P-450LTB omega is classified into the CYP4 family but does not belong to any of the known CYP4 subfamilies.', select the correct biomedical concept corresponding to 'p-450ltb omega'. Answer using one of the provided opti... | <Options>: A: p-450ib (oryctolagus cuniculus) (aka cytochrome p450 family 2 subfamily j member 2)
B: ltb4h (homo sapiens) (aka cytochrome p450 family 4 subfamily f member 3)
C: cyp2e (oryctolagus cuniculus) (aka cytochrome p450 2e1)
D: cytochrome p450 lm4 (oryctolagus cuniculus) (aka cytochrome p450 lm4)
E: ltb4dh (ory... | B |
<Instruct>: Given the context 'Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase epsilon.
', select the correct biomedical concept corresponding to 'catalytic subunit of human dna polymerase epsilon'. Answer using one of the provided options. | <Options>: A: dna polymerase epsilon 4, accessory subunit (homo sapiens) (aka dna polymerase epsilon 4, accessory subunit)
B: dna polymerase gamma, catalytic subunit (homo sapiens) (aka dna polymerase gamma, catalytic subunit)
C: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, cata... | E |
<Instruct>: Given the context 'The cDNA encoding the catalytic polypeptide of human DNA polymerase epsilon was cloned.', select the correct biomedical concept corresponding to 'catalytic polypeptide of human dna polymerase epsilon'. Answer using one of the provided options. | <Options>: A: dna polymerase delta 1, catalytic subunit (homo sapiens) (aka dna polymerase delta 1, catalytic subunit)
B: dna polymerase epsilon 4, accessory subunit (homo sapiens) (aka dna polymerase epsilon 4, accessory subunit)
C: dna polymerase epsilon, catalytic subunit (homo sapiens) (aka dna polymerase epsilon, ... | C |
<Instruct>: Given the context 'cDNA cloning and mitochondrial import of the beta-subunit of the human electron-transfer flavoprotein.
', select the correct biomedical concept corresponding to 'beta-subunit of the human electron-transfer flavoprotein'. Answer using one of the provided options. | <Options>: A: hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit beta (homo sapiens) (aka hydroxyacyl-coa dehydrogenase trifunctional multienzyme complex subunit beta)
B: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
C: electron transfe... | B |
<Instruct>: Given the context 'We have isolated a cDNA clone which encodes the entire beta-subunit of human electron-transferring flavoprotein (ETF) by screening an expression library from human liver using polyclonal antibodies against porcine ETF.', select the correct biomedical concept corresponding to 'beta-subunit... | <Options>: A: electron transfer flavoprotein regulatory factor 1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
B: electron transfer flavoprotein subunit beta (bos taurus) (aka electron transfer flavoprotein subunit beta)
C: electron transfer flavoprotein subunit beta (sus scrofa) (aka electron... | E |
<Instruct>: Given the context 'This cDNA encodes a protein of 255 amino-acid residues with a predicted molecular mass of 27,877 Da which shows a high degree of similarity with partial amino-acid sequences obtained from both rat liver and Paracoccus denitrificans beta-ETF.', select the correct biomedical concept corresp... | <Options>: A: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
D: ebf (homo sapiens) (aka ebf transcription factor 1)
E: electron transfer flavoprotein subunit beta (homo sapiens... | E |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: tcfeb (homo sapiens) (aka transcription factor eb)
B: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
C: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
D: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory fact... | C |
<Instruct>: Given the context 'Northern-blot analysis shows that the human beta-ETF mRNA is approximately 1 kb in size and is abundant in liver, heart and skeletal muscle.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: tcfeb (homo sapiens) (aka transcription factor eb)
B: ecgf-beta (homo sapiens) (aka fibroblast growth factor 1)
C: etf (homo sapiens) (aka tea domain transcription factor 2)
D: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
E: hrtef-1b (homo sapiens) (aka tea domain transcr... | F |
<Instruct>: Given the context 'Incubation with intact mitochondria indicates that the cDNA-encoded beta-ETF polypeptide contains the information necessary to reach the mitochondrial matrix.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
B: ebf (homo sapiens) (aka ebf transcription factor 1)
C: etf (homo sapiens) (aka tea domain transcription factor 2)
D: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta... | D |
<Instruct>: Given the context 'These data are in agreement with previous experiments suggesting that beta-ETF, unlike the majority of nuclear-encoded mitochondrial matrix proteins, does not have a cleavable leader peptide.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the prov... | <Options>: A: ebf (homo sapiens) (aka ebf transcription factor 1)
B: tcfeb (homo sapiens) (aka transcription factor eb)
C: etfrf1 (homo sapiens) (aka electron transfer flavoprotein regulatory factor 1)
D: hrtef-1b (homo sapiens) (aka tea domain transcription factor 4)
E: etfb (homo sapiens) (aka electron transfer flavo... | E |
<Instruct>: Given the context 'Interestingly, the sequence analysis of beta-ETF protein identifies a 26.3% identity with the Fix A gene product of the nitrogen-fixing bacterium Azorhizobium caulinodans.', select the correct biomedical concept corresponding to 'beta-etf'. Answer using one of the provided options. | <Options>: A: electron transfer flavoprotein subunit beta (homo sapiens) (aka electron transfer flavoprotein subunit beta)
B: ebf (homo sapiens) (aka ebf transcription factor 1)
C: etf1 (homo sapiens) (aka eukaryotic translation termination factor 1)
D: tcfeb (homo sapiens) (aka transcription factor eb)
E: etfb (bos ta... | A |
<Instruct>: Given the context 'Human cDNAs for cytosolic and mitochondrial serine hydroxymethyltransferase (SHMT) were cloned by functional complementation of an Escherichia coli glyA mutant with a human cDNA library.', select the correct biomedical concept corresponding to 'glya'. Answer using one of the provided opti... | <Options>: A: glyii-1 (glycine max) (aka hydroxyacylglutathione hydrolase cytoplasmic-like)
B: gly1 (homo sapiens) (aka threonine aldolase 1, pseudogene)
C: glya (escherichia coli str. k-12 substr. mg1655) (aka serine hydroxymethyltransferase)
D: cytosolic glutamine synthetase alpha (glycine max) (aka cytosolic glutami... | C |
<Instruct>: Given the context 'Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.
', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
B: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
C: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
D: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
E: fkbpl (homo sapiens) (aka fkb... | C |
<Instruct>: Given the context 'CaN is the target of the immunosuppressive drugs cyclosporin A and FK506, which inhibit CaN after forming complexes with cytoplasmic binding proteins (cyclophilin and FKBP12, respectively).', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided... | <Options>: A: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
B: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
C: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
D: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
E: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
F: None of the a... | A |
<Instruct>: Given the context 'We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
B: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
C: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
D: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
E: fkbpl (hom... | A |
<Instruct>: Given the context 'In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
B: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
C: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
D: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
E: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
F: ... | A |
<Instruct>: Given the context 'The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
B: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
C: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
D: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
E: fkbp-12 (homo sapiens) (aka fkbp prolyl isomerase 1a)
F: N... | E |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: hcca1 (homo sapiens) (aka yy1 associated protein 1)
E: hcc2 (homo sapiens) (aka thioredoxin domain containing ... | A |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc3 (homo sapiens) (aka fun14 domain containing 2)
B: hccr1 (homo sapiens) (aka letm1 domain containing 1)
C: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
D: hcca1 (homo sapiens) (aka yy1 associated protein 1)
E: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
F: None of the abov... | F |
<Instruct>: Given the context 'A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hccr1 (homo sapiens) (aka letm1 domain containing 1)
C: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
D: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
E: hcc3 (homo sapiens) (aka fun14 domain contain... | A |
<Instruct>: Given the context 'HCC-1 has a relative molecular mass of 8,673 and consists of 74 amino acids including four cysteines linked to disulfide bonds.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcc3 (homo sapiens) (aka fun14 domain con... | D |
<Instruct>: Given the context 'HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hccr1 (homo sapiens) (aka letm1 domain containing 1)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcca1 (homo sapiens) (aka yy1 associated protein 1)
F:... | D |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
F: None o... | A |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'macrophage inflammatory protein (mip)-1 alpha'. Answer using one of the pro... | <Options>: A: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
B: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
C: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
D: mcp-1 (homo sapiens) (aka c-c motif chemokine ligand 2)
E: mip-1d (homo sapiens) (aka ... | A |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'mip-1 beta'. Answer using one of the provided options. | <Options>: A: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
B: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 like 1 (homo sapiens)) (aka c-c motif chemokine ligand 4 like 1)
C: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
D: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
... | D |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept corresponding to... | <Options>: A: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
B: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
C: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
D: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
E: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c ... | B |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept corresponding to... | <Options>: A: hcc3 (homo sapiens) (aka fun14 domain containing 2)
B: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcc2 (homo sapiens) (aka thioredoxin domain conta... | D |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hcc3 (homo sapiens) (aka fun14 domain containing 2)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
E: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
F: ... | E |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
B: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
C: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
D: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
E: mip-4a (homo sapiens) (aka c-c ... | C |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
B: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
C: mip-1d (homo sapiens) (aka c-c motif chemokine ligand 15)
D: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
E: mip1ap (homo sapiens) (aka c-c motif chemok... | F |
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