instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6
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<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept corresponding to 'norrin'. Answer using one of the pro... | <Options>: A: connectin (rattus norvegicus) (aka titin)
B: nynrin (rattus norvegicus) (aka nyn domain and retroviral integrase containing)
C: norrin cystine knot growth factor ndp (homo sapiens) (aka norrin cystine knot growth factor ndp)
D: norbin (rattus norvegicus) (aka neurochondrin)
E: norrin cystine knot growth f... | C |
<Instruct>: Given the context 'We suggest that Coats' telangiectasis is secondary to somatic mutation in the NDP gene which results in a deficiency of norrin (the protein product of the NDP gene) within the developing retina.', select the correct biomedical concept corresponding to 'ndp'. Answer using one of the provid... | <Options>: A: ndp (rattus norvegicus) (aka norrin cystine knot growth factor ndp)
B: ndp (xenopus tropicalis) (aka norrin cystine knot growth factor ndp)
C: ndnf (homo sapiens) (aka neuron derived neurotrophic factor)
D: ndc1 transmembrane nucleoporin (homo sapiens) (aka ndc1 transmembrane nucleoporin)
E: ndp (homo sap... | E |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept corresponding to 'luteinizing hormone beta-subunit'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
B: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
C: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
D: lhb (homo sapiens) (c... | B |
<Instruct>: Given the context 'A common polymorphic allele of the human luteinizing hormone beta-subunit gene: additional mutations and differential function of the promoter sequence.
', select the correct biomedical concept corresponding to 'luteinizing hormone beta-subunit'. Answer using one of the provided options. | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: follicle stimulating hormone subunit beta (homo sapiens) (aka follicle stimulating hormone subunit beta)
D: chorionic gonadotropin subunit beta 1 (homo ... | F |
<Instruct>: Given the context 'A common genetic variant (V) of the human luteinizing hormone (LH) beta-subunit gene was recently discovered.', select the correct biomedical concept corresponding to 'luteinizing hormone (lh) beta-subunit'. Answer using one of the provided options. | <Options>: A: chorionic gonadotropin subunit beta 1 (homo sapiens) (aka chorionic gonadotropin subunit beta 1)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
D: follicle stimulating hormone subunit beta (homo sapi... | E |
<Instruct>: Given the context 'The V-LH molecules have higher bioactivity in vitro, but shorter half-life in circulation, which apparently is related to the alterations of LH function observed in individuals homo- and heterozygous for the V-LHbeta allele.', select the correct biomedical concept corresponding to 'lhbeta... | <Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizi... | B |
<Instruct>: Given the context 'We have now studied whether additional mutations in the V-LHbeta promoter sequence could contribute to the altered physiology of the LH variant molecules.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: lhb (homo sapiens) (luteinizing hormon... | D |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided ... | <Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (sus ... | E |
<Instruct>: Given the context 'The 661 bp 5'-flanking region of the V-LHbeta gene, retrieved from human genomic DNA by PCR, contained eight single-nucleotide changes, as compared with the wild-type (wt) LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided ... | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizin... | C |
<Instruct>: Given the context 'Reporter constructs with various lengths of the wt- and V-LH promoter sequences, driving the firefly luciferase reporter gene, were transfected into an immortalized mouse pituitary cell line, LbetaT(2), known to express the endogenous LHbeta gene, and into a non-endocrine human embryonic ... | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (oryctolagus cuniculus)... | E |
<Instruct>: Given the context 'Basal expression levels of the V-LHbeta promoter constructs were on average 36% higher in LbetaT(2)cells ( P < 0.001; n = 29), and 40% higher in HEK 293 cells ( P < 0.001; n = 16), as compared with the respective wt sequences.', select the correct biomedical concept corresponding to 'lhbe... | <Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (homo sapiens) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (bos taurus) (aka l... | B |
<Instruct>: Given the context 'Numerous qualitative and quantitative differences were found between the two cell lines in responses of the two promoter sequences to stimulation with 12- O -tetradecanoylphorbol-13-acetate, forskolin, 8-bromo-cAMP, progesterone and gonado- tropin-releasing hormone.', select the correct b... | <Options>: A: growth hormone releasing hormone (homo sapiens) (aka growth hormone releasing hormone)
B: growth hormone releasing hormone (xenopus tropicalis) (aka growth hormone releasing hormone)
C: growth hormone releasing hormone (rattus norvegicus) (aka growth hormone releasing hormone)
D: hypocretin (orexin) neuro... | E |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta-like (xenopus laevis) (aka lutropin subunit beta-like)
B: lutropin subunit beta (bos taurus) (aka lutropin subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subun... | E |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: lutropin subunit beta-like (xenopus laevis) (a... | E |
<Instruct>: Given the context 'In conclusion, the V-LHbeta promoter has higher basal activity, and differs in response to hormonal stimulation, as compared with the wt-LHbeta promoter.', select the correct biomedical concept corresponding to 'lhbeta'. Answer using one of the provided options. | <Options>: A: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
B: luteinizing hormone subunit beta (xenopus tropicalis) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit... | F |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Options>: A: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
C: lutropin subunit beta-like (xenopus tropicalis) (aka lutropin subunit beta-like)
D: luteinizing ... | A |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: luteinizing hormone subunit beta (bos taurus) (aka luteinizing hormone subunit beta)
C: lsh-beta (homo sapiens) (aka luteinizing hormone subunit beta)
D: luteinizing hormone subunit beta (xenopus tropicalis)... | C |
<Instruct>: Given the context 'The altered promoter function of the V-LHbeta gene provides evidence for differences in regulation of the wt- and V-LHbeta genes, which may contribute to the differences observed in pituitary-gonadal function between carriers of the two LHbeta alleles.', select the correct biomedical conc... | <Options>: A: luteinizing hormone subunit beta (oryctolagus cuniculus) (aka luteinizing hormone subunit beta)
B: lhb (homo sapiens) (luteinizing hormone subunit beta (homo sapiens)) (aka luteinizing hormone subunit beta)
C: luteinizing hormone subunit beta (sus scrofa) (aka luteinizing hormone subunit beta)
D: lutropin... | B |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept corresponding to 'hydroxypyruvate reductase'. Answer using one of the provided options. | <Options>: A: grhpr (xenopus tropicalis) (glyoxylate reductase/hydroxypyruvate reductase, gene 1 (xenopus tropicalis)) (aka glyoxylate reductase/hydroxypyruvate reductase, gene 1)
B: glyoxylate and hydroxypyruvate reductase (bos taurus) (aka glyoxylate and hydroxypyruvate reductase)
C: hdhpr (homo sapiens) (aka quinoid... | D |
<Instruct>: Given the context 'The gene encoding hydroxypyruvate reductase (GRHPR) is mutated in patients with primary hyperoxaluria type II.
', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: grr1 (glycine max) (aka putative ein3-binding f-box protein)
D: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
E: growth ho... | A |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept corresponding to 'glyoxylate reductase'. Answer using one of the provided options. | <Options>: A: glyoxylate reductase 1 homolog (sus scrofa) (aka glyoxylate reductase 1 homolog)
B: glyoxylate reductase (escherichia coli str. k-12 substr. mg1655) (aka glyoxylate reductase)
C: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: glyoxylate reductase ... | C |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept corresponding to 'hydroxypyruvate reductase'. Answer using one of the provided options. | <Options>: A: glyoxylate reductase 1 homolog (xenopus tropicalis) (aka glyoxylate reductase 1 homolog)
B: glyoxylate and hydroxypyruvate reductase (rattus norvegicus) (aka glyoxylate and hydroxypyruvate reductase)
C: hydroxypyruvate reductase (arabidopsis thaliana) (aka hydroxypyruvate reductase)
D: glyoxylate and hydr... | D |
<Instruct>: Given the context 'We identified a glyoxylate reductase/hydroxypyruvate reductase (GRHPR) cDNA clone from a human liver expressed sequence tag (EST) library.', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
B: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
D: grpr (homo sapiens) (aka gastrin releasing peptide rec... | B |
<Instruct>: Given the context 'Transient transfection of the cDNA clone into COS cells verified that it encoded an enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities.', select the correct biomedical concept corresponding to 'glyoxylate reductase'. Answer usin... | <Options>: A: glyoxylate reductase 1 homolog (sus scrofa) (aka glyoxylate reductase 1 homolog)
B: reductase (glycine max) (aka chalcone reductase chr1)
C: glyoxylate reductase 1 (arabidopsis thaliana) (aka glyoxylate reductase 1)
D: glyoxylate and hydroxypyruvate reductase (homo sapiens) (aka glyoxylate and hydroxypyru... | D |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: grr1 (glycine max) (aka putative ein3-binding f-box protein)
B: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
D: grhr (homo sapiens) (aka gonadotropin releasing hormone recepto... | B |
<Instruct>: Given the context 'The genomic structure of the human GRHPR gene was determined and contains nine exons and eight introns and spans approximately 9 kb pericentromeric on chromosome 9.', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
B: gr (homo sapiens) (aka nuclear receptor subfamily 3 group c member 1)
C: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
D: grr1 (glycine max) (aka putative ein3-binding f-box protein)
E: growth ... | F |
<Instruct>: Given the context 'Four PH2 patients representing two pairs of siblings from two unrelated families were analyzed for mutations in GRHPR by single strand conformation polymorphism analysis.', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: grhr (homo sapiens) (aka gonadotropin releasing hormone receptor)
B: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
C: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
D: grr1 (glycine max) (aka putative ein3-binding f-box protein)
E: ghrh... | C |
<Instruct>: Given the context 'The cDNA that we have identified represents the first characterization of an animal GRHPR sequence.', select the correct biomedical concept corresponding to 'grhpr'. Answer using one of the provided options. | <Options>: A: prolactin releasing hormone receptor (homo sapiens) (aka prolactin releasing hormone receptor)
B: grhpr (homo sapiens) (aka glyoxylate and hydroxypyruvate reductase)
C: grpr (homo sapiens) (aka gastrin releasing peptide receptor)
D: grr1 (glycine max) (aka putative ein3-binding f-box protein)
E: ghrhr (ho... | B |
<Instruct>: Given the context 'Ectodysplasin is a collagenous trimeric type II membrane protein with a tumor necrosis factor-like domain and co-localizes with cytoskeletal structures at lateral and apical surfaces of cells.
', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of t... | <Options>: A: ectodysplasin a (homo sapiens) (aka ectodysplasin a)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
E: ectodysplasin a (sus scrofa) (aka ectodysplasin a)
F: None of... | A |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept corresponding to 'ectodermal dysplasia'. Answer using one of the provided options. | <Options>: A: ectodermal dysplasia 8, hair/tooth/nail type (homo sapiens) (aka ectodermal dysplasia 8, hair/tooth/nail type)
B: asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome) (homo sapiens) (aka asphixiating thoracic dystrophy (chondroectodermal dysplasia-like syndrome))
C: ectodermal dyspl... | F |
<Instruct>: Given the context 'Anhidrotic ectodermal dysplasia (EDA) is a human genetic disorder of impaired ectodermal appendage development.', select the correct biomedical concept corresponding to 'eda'. Answer using one of the provided options. | <Options>: A: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
B: edd (arabidopsis thaliana) (aka glycine-trna ligase)
C: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
D: eda1r (homo sapiens) (aka ectodysplasin a receptor)
E... | E |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept corresponding to 'eda'. Answer using one of the provided options. | <Options>: A: eda1 (homo sapiens) (aka ectodysplasin a)
B: eda1 (arabidopsis thaliana) (aka f-box associated ubiquitination effector family protein)
C: eda1 (xenopus laevis) (ectodysplasin a s homeolog (xenopus laevis)) (aka ectodysplasin a s homeolog)
D: edd (arabidopsis thaliana) (aka glycine-trna ligase)
E: eda3 (ho... | A |
<Instruct>: Given the context 'The EDA gene encodes isoforms of a novel transmembrane protein, ectodysplasin.', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of the provided options. | <Options>: A: ectodysplasin a (danio rerio) (aka ectodysplasin a)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
D: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
E: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (ak... | E |
<Instruct>: Given the context 'In order to understand better the function of the ectodysplasin protein molecule and its domains, we have studied the processing and localization of wild-type and mutated isoforms in transfected human fetal kidney 293 and monkey kidney COS-1 cells.', select the correct biomedical concept ... | <Options>: A: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
B: ectodysplasin a (homo sapiens) (aka ectodysplasin a)
C: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
D: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
E: ectodysplasin a (sus scrofa) (aka ... | B |
<Instruct>: Given the context 'Similar to other members of collagenous membrane proteins and members of TNF-related ligands, ectodysplasin is a type II membrane protein and it forms trimers.', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of the provided options. | <Options>: A: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
B: ectd1 (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
C: ectodysplasin a (danio rerio) (aka ectodysplasin a)
D: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
E: ectodysplasin a (s... | B |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of the provided options. | <Options>: A: hed (homo sapiens) (ectodysplasin a (homo sapiens)) (aka ectodysplasin a)
B: ectodysplasin a (bos taurus) (aka ectodysplasin a)
C: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
D: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
E: ectodysplasin a (sus ... | A |
<Instruct>: Given the context 'The membrane localization of ectodysplasin is asymmetrical: it is found on the apical and lateral surfaces of the cells where it co-localizes with cytoskeletal structures.', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of the provided options. | <Options>: A: ectodysplasin a receptor (homo sapiens) (aka ectodysplasin a receptor)
B: ectodysplasin a receptor (xenopus tropicalis) (aka ectodysplasin a receptor)
C: ectodysplasin a (xenopus tropicalis) (aka ectodysplasin a)
D: ectodysplasin a (danio rerio) (aka ectodysplasin a)
E: ectodysplasin a (sus scrofa) (aka e... | F |
<Instruct>: Given the context 'Our results suggest that ectodysplasin is a new member in the TNF-related ligand family involved in the early epithelial-mesenchymal interaction that regulates ectodermal appendage formation.', select the correct biomedical concept corresponding to 'ectodysplasin'. Answer using one of the... | <Options>: A: ectodysplasin a (bos taurus) (aka ectodysplasin a)
B: ectodysplasin a (danio rerio) (aka ectodysplasin a)
C: ed3 (homo sapiens) (ectodysplasin a receptor (homo sapiens)) (aka ectodysplasin a receptor)
D: ectodysplasin a (homo sapiens) (aka ectodysplasin a)
E: ectodysplasin a receptor (xenopus tropicalis) ... | D |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept corresponding to 'bis'. Answer using one o... | <Options>: A: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
B: bis (drosophila melanogaster) (aka bistre)
C: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
D: bisc (drosophila melanogaster) (aka biscotti)
E: bisb (escherichia coli str. k-12 substr. mg1655) (aka mo... | F |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one... | <Options>: A: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bcl2 (homo sapiens) (aka bcl2 apoptosis regulator)
D: bcl2-l-2 (homo sapiens) (aka bcl2 like 2)
E: bcl2l (homo sapiens) (aka bcl2 like 1)
F: None of the above. | C |
<Instruct>: Given the context 'Bis, a Bcl-2-binding protein that synergizes with Bcl-2 in preventing cell death.
Bcl-2 is the best characterized inhibitor of apoptosis, although the molecular basis of this action is not fully understood.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one... | <Options>: A: bcl2l2 (homo sapiens) (aka bcl2 like 2)
B: bcl2l (homo sapiens) (aka bcl2 like 1)
C: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
D: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
E: bcl-b (homo sapiens) (aka bcl2 like 10)
F: None of the above. | D |
<Instruct>: Given the context 'Using a protein interaction cloning procedure, we identified a human gene designated as bis (mapped to chromosome 10q25) that encoded a novel Bcl-2-interacting protein.', select the correct biomedical concept corresponding to 'bis'. Answer using one of the provided options. | <Options>: A: bisb (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin molybdotransferase)
B: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
C: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
D: bi (homo sapiens) (aka calcium voltage-gated channel subunit... | F |
<Instruct>: Given the context 'Bis protein showed no significant homology with Bcl-2 family proteins and had no prominent functional motif.', select the correct biomedical concept corresponding to 'bis'. Answer using one of the provided options. | <Options>: A: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
B: bis (mus musculus) (aka bcl2-associated athanogene 3)
C: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)
D: bpids (homo sapiens) (aka ubiquitin protein ligase e3b)
E: bisb (escherichia coli str. k-12... | F |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept corresponding to 'bis'. Answer using one of the provided options. | <Options>: A: bis1 (mus musculus) (aka beta-carboline-induced seizures 1)
B: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: bis (mus musculus) (aka bcl2-associated athanogene 3)
D: bis1 (hom... | F |
<Instruct>: Given the context 'Co-immunoprecipitation analysis confirmed that Bis interacted with Bcl-2 in vivo.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one of the provided options. | <Options>: A: bcl-b (homo sapiens) (aka bcl2 like 10)
B: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
C: bcl2 like 2 (homo sapiens) (aka bcl2 like 2)
D: ccnb2 (homo sapiens) (aka cyclin b2)
E: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
F: None of the above. | B |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept corresponding to 'bis'. Answer using one of the provided options. | <Options>: A: bisc (drosophila melanogaster) (aka biscotti)
B: bis (homo sapiens) (swi/snf related baf chromatin remodeling complex subunit atpase 2 (homo sapiens)) (aka swi/snf related baf chromatin remodeling complex subunit atpase 2)
C: bi (homo sapiens) (aka calcium voltage-gated channel subunit alpha1 a)
D: bis (d... | F |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one of the provided options... | <Options>: A: bcl2l (homo sapiens) (aka bcl2 like 1)
B: ccnb2 (homo sapiens) (aka cyclin b2)
C: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
D: bcl-b (homo sapiens) (aka bcl2 like 10)
E: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
F: None of the above. | E |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one of the provided options... | <Options>: A: bcl2l2 (homo sapiens) (aka bcl2 like 2)
B: bcl2l (homo sapiens) (aka bcl2 like 1)
C: bcl-b (homo sapiens) (aka bcl2 like 10)
D: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
E: ccnb2 (homo sapiens) (aka cyclin b2)
F: None of the above. | F |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept corresponding to 'bax'. Answer using one of the provided options. | <Options>: A: bcl-x (homo sapiens) (aka bcl2 like 1)
B: bcl2 apoptosis regulator (homo sapiens) (aka bcl2 apoptosis regulator)
C: bax (escherichia coli str. k-12 substr. mg1655) (aka putative glycoside hydrolase bax)
D: bak (homo sapiens) (aka bcl2 antagonist/killer 1)
E: bcl2 associated x, apoptosis regulator (homo sa... | E |
<Instruct>: Given the context 'DNA transfection experiments indicated that Bis itself exerted only weak anti-apoptotic activity, but was synergistic with Bcl-2 in preventing Bax-induced and Fas-mediated apoptosis.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
C: fasas (homo sapiens) (aka fas antisense rna 1)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: fast (homo sapiens) (fas activated se... | B |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept corresponding to 'bis'. Answer using one of the provided options. | <Options>: A: bisc (drosophila melanogaster) (aka biscotti)
B: bis (mus musculus) (aka bcl2-associated athanogene 3)
C: bis (drosophila melanogaster) (aka bistre)
D: bisd (escherichia coli str. k-12 substr. mg1655) (aka molybdopterin adenylyltransferase)
E: bis1 (homo sapiens) (aka ess-2 spliceosome associated protein)... | F |
<Instruct>: Given the context 'These results suggest that Bis is a novel modulator of cellular anti-apoptotic activity that functions through its interaction with Bcl-2.', select the correct biomedical concept corresponding to 'bcl-2'. Answer using one of the provided options. | <Options>: A: bcl-2 (homo sapiens) (aka bcl2 apoptosis regulator)
B: bcl-b (homo sapiens) (aka bcl2 like 10)
C: bcl2-l-2 (homo sapiens) (aka bcl2 like 2)
D: bcl2 interacting protein 2 (homo sapiens) (aka bcl2 interacting protein 2)
E: ccnb2 (homo sapiens) (aka cyclin b2)
F: None of the above. | A |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E: ... | B |
<Instruct>: Given the context 'BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells.
BACKGROUND: Treatment of breast cancer with the antiestrogen tamoxifen is effective in approximately one half of the patients with estrogen receptor-positive disease, but tumors re... | <Options>: A: p120cas (homo sapiens) (aka catenin delta 1)
B: p130cas (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: p130cas (sus scrofa) (aka bcar1 scaffold protein, cas family member)
D: p130cas (rattus norvegicus) (aka bcar1 scaffold protein, cas family member)
E: p120cas (xenopus tropicalis) (aka... | B |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept corresponding to 'breast cancer antiestrogen resistance 1'. Answer using one of the provided options. | <Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcan antisense rna 1 (homo sapiens) (aka bcan antisense rna 1)
C: bcar3 antisense rna 1 (homo sapiens) (aka bcar3 antisense rna 1)
D: breast cancer anti-estrogen resistance 1 (mus musculus) (aka bre... | A |
<Instruct>: Given the context 'In this study, we isolated and characterized the crucial gene at the breast cancer antiestrogen resistance 1 (BCAR1) locus.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
D: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: bcar2 (homo sa... | D |
<Instruct>: Given the context 'Transfer of the BCAR1 locus from retrovirus-mutated, antiestrogen-resistant cells to estrogen-dependent ZR-75-1 cells by cell fusion conferred an antiestrogen-resistant phenotype on the recipient cells.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of ... | <Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c... | B |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar1 pseudogene 1 (homo sapiens) (... | B |
<Instruct>: Given the context 'The complete coding sequence of BCAR1 was isolated by use of exon-trapping and complementary DNA (cDNA) library screening.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
B: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
C: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar1 (xeno... | F |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar1 (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
E: bcar2 (homo sapiens) (aka transc... | A |
<Instruct>: Given the context 'Sequence analysis of human BCAR1 cDNA predicted a protein of 870 amino acids that was strongly homologous to rat p130Cas-adapter protein.', select the correct biomedical concept corresponding to 'p130cas-adapter protein'. Answer using one of the provided options. | <Options>: A: cas1 (homo sapiens) (bcar1 scaffold protein, cas family member (homo sapiens)) (aka bcar1 scaffold protein, cas family member)
B: p130cas (drosophila melanogaster) (aka p130cas)
C: p130cas (xenopus laevis) (bcar1, cas family scaffold protein l homeolog (xenopus laevis)) (aka bcar1, cas family scaffold pro... | D |
<Instruct>: Given the context 'Genomic analysis revealed that BCAR1 consists of seven exons and is located at chromosome 16q23.1.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
B: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
C: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
D: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
E: ... | D |
<Instruct>: Given the context 'BCAR1 transcripts were detected in multiple human tissues and were similar in size to transcripts produced by retrovirus-mutated ZR-75-1 cells.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
D: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
E: bcar1 (homo sapiens) (... | E |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided op... | <Options>: A: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
B: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
C: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
D: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
E: bcar2 ... | A |
<Instruct>: Given the context 'Transfection of BCAR1 cDNA into ZR-75-1 cells again resulted in sustained cell proliferation in the presence of antiestrogens, confirming that BCAR1 was the responsible gene in the locus.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided op... | <Options>: A: bca-1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
B: bcar1 scaffold protein, cas family member (homo sapiens) (aka bcar1 scaffold protein, cas family member)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1... | B |
<Instruct>: Given the context 'Overexpression of the BCAR1 gene confers antiestrogen resistance on human ZR-75-1 breast cancer cells.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar1 pseudogene 1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 (xenopus tropicalis) (aka bcar1, cas family scaffold protein)
D: bcar1 scaffold protein, cas family member (bos taurus) (aka bcar1 scaffold protein, cas family member)
E: bcar1 ... | E |
<Instruct>: Given the context 'Overexpression of BCAR1 in retrovirus-mutated cells appears to result from activation of the gene's promoter.', select the correct biomedical concept corresponding to 'bcar1'. Answer using one of the provided options. | <Options>: A: bcar1p1 (homo sapiens) (aka bcar1 pseudogene 1)
B: bca1 (homo sapiens) (aka c-x-c motif chemokine ligand 13)
C: bcar1 (bos taurus) (aka bcar1 scaffold protein, cas family member)
D: bcar2 (homo sapiens) (aka transcriptional regulating factor 1)
E: bcar1 scaffold protein, cas family member (homo sapiens) (... | E |
<Instruct>: Given the context 'Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules.
', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
B: cd206 (homo sapiens) (aka mannose receptor c-type 1)
C: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
D: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
E:... | E |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
D: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
E: cd206 (homo... | A |
<Instruct>: Given the context 'We have identified a type II Ca2+-dependent lectin displaying mannose-binding specificity, exclusively expressed by Langerhans cells (LC), and named Langerin.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd206 (homo sapiens) (aka mannose receptor c-type 1)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
D: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
E: cd20-li... | F |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
B: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
C: cd207 (homo sapiens) (aka cd207 molecule)
D: cd206 (homo sapiens) (aka mannose receptor c-type 1)
E: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
F: None of the... | C |
<Instruct>: Given the context 'Here, we have shown that Langerin is constitutively associated with BG and that antibody to Langerin is internalized into these structures.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd20l7 (homo sapiens) (aka membrane spanning 4-domains a10)
B: cd207 molecule (homo sapiens) (aka cd207 molecule)
C: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
D: cd20l1 (homo sapiens) (aka membrane spanning 4-domains a4a)
E: cd206 (homo sapiens) (aka mannose receptor c-type 1)
F: ... | B |
<Instruct>: Given the context 'Remarkably, transfection of Langerin cDNA into fibroblasts created a compact network of membrane structures with typical features of BG.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
B: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
C: cd207 molecule (homo sapiens) (aka cd207 molecule)
D: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
E: cd20l1 (hom... | C |
<Instruct>: Given the context 'Langerin is thus a potent inducer of membrane superimposition and zippering leading to BG formation.', select the correct biomedical concept corresponding to 'langerin'. Answer using one of the provided options. | <Options>: A: cd207 (homo sapiens) (aka cd207 molecule)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd20-like (xenopus tropicalis) (aka membrane spanning 4-domains a1)
D: cd209 antigen-like protein a (xenopus tropicalis) (clec9a (xenopus tropicalis)) (aka cd209 antigen-like protein a)
E: cd208 (hom... | A |
<Instruct>: Given the context 'Our data suggest that induction of BG is a consequence of the antigen-capture function of Langerin, allowing routing into these organelles and providing access to a nonclassical antigen-processing pathway.', select the correct biomedical concept corresponding to 'langerin'. Answer using o... | <Options>: A: cd207 molecule (homo sapiens) (aka cd207 molecule)
B: cd20l5 (homo sapiens) (aka membrane spanning 4-domains a8)
C: cd208 (homo sapiens) (aka lysosomal associated membrane protein 3)
D: cd206 (homo sapiens) (aka mannose receptor c-type 1)
E: cd20l (homo sapiens) (aka membrane spanning 4-domains a3)
F: Non... | A |
<Instruct>: Given the context 'Cloning and characterisation of the Sry-related transcription factor gene Sox8.
', select the correct biomedical concept corresponding to 'sox8'. Answer using one of the provided options. | <Options>: A: sry-box 8 (gallus gallus) (aka sry-box 8)
B: sox8 (danio rerio) (aka sry-box transcription factor 8b)
C: sox8 (homo sapiens) (aka sry-box transcription factor 8)
D: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
E: sox8 (sus scrofa) (aka sry-bo... | C |
<Instruct>: Given the context 'We report here the isolation of Sox8 and its characterisation in mice and humans.', select the correct biomedical concept corresponding to 'sox8'. Answer using one of the provided options. | <Options>: A: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
B: sry-box 8 (gallus gallus) (aka sry-box 8)
C: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
D: sox8 (xenopus tropicalis) (aka sry-box 8)
E: sox8 (homo sapiens) (aka sry-box trans... | E |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept corresponding to 'sox9'. Answer using one of the provided options. | <Options>: A: sox9 (xenopus tropicalis) (aka sry-box 9)
B: sox9 (gallus gallus) (aka sry-box 9)
C: sox9 (xenopus laevis) (sry-box 9 l homeolog (xenopus laevis)) (aka sry-box 9 l homeolog)
D: sox9 promoter region (homo sapiens) (aka sox9 promoter region)
E: sox9 (homo sapiens) (aka sry-box transcription factor 9)
F: Non... | E |
<Instruct>: Given the context 'This gene has a remarkably similar primary structure and genomic organisation to the campomelic dysplasia gene SOX9 and the Waardenburg-Shah syndrome gene SOX10.', select the correct biomedical concept corresponding to 'sox10'. Answer using one of the provided options. | <Options>: A: sox-10 (homo sapiens) (aka sry-box transcription factor 10)
B: sox10 (gallus gallus) (aka sry-box 10)
C: sox10 (xenopus tropicalis) (aka sry-box 10)
D: sox10 (danio rerio) (aka sry-box transcription factor 10)
E: sox10 (xenopus laevis) (aka sry-box 10 l homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept corresponding to 'sox8'. Answer using one of the provided options. | <Options>: A: sry-box 8 (gallus gallus) (aka sry-box 8)
B: sox8 (homo sapiens) (aka sry-box transcription factor 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E: sox8 (xenopus tropicalis) (aka sry-box 8)
F: None of the above. | B |
<Instruct>: Given the context 'SOX8 protein is able to bind to canonical SOX target DNA sequences and activate transcription in vitro through two separate trans -activation regions.', select the correct biomedical concept corresponding to 'sox8'. Answer using one of the provided options. | <Options>: A: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
B: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
C: sox8 (danio rerio) (aka sry-box transcription factor 8b)
D: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
E: sry-box 8 (gallu... | F |
<Instruct>: Given the context 'Further, Sox8 is expressed in the central nervous system, limbs, kidneys, gonads and craniofacial structures during mouse embryo development.', select the correct biomedical concept corresponding to 'sox8'. Answer using one of the provided options. | <Options>: A: sox8 (danio rerio) (aka sry-box transcription factor 8b)
B: sox8 (homo sapiens) (aka sry-box transcription factor 8)
C: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
D: sox8 (mus musculus) (aka sry (sex determining region y)-box 8)
E: sox8 (xe... | B |
<Instruct>: Given the context 'Sox8 maps to the t complex on mouse chromosome 17 and to human chromosome 16p13.3, a region associated with the microphthalmia-cataract syndrome CATM and the alpha-thalassemia/mental retardation syndrome ATR-16.', select the correct biomedical concept corresponding to 'sox8'. Answer using... | <Options>: A: sox8 (homo sapiens) (aka sry-box transcription factor 8)
B: sry-box 8 (gallus gallus) (aka sry-box 8)
C: sox8 (xenopus laevis) (aka sry-box 8 l homeolog)
D: sox10 multiple-species conserved sequence 8 (mus musculus) (aka sox10 multiple-species conserved sequence 8)
E: sox8 (danio rerio) (aka sry-box trans... | A |
<Instruct>: Given the context 'Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly.
', select the correct biomedical concept corresponding to 'syntaphilin'. Answer using one of the provided options. | <Options>: A: syntaphilin (homo sapiens) (aka syntaphilin)
B: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
C: syntaphilin (xenopus tropicalis) (aka syntaphilin)
D: syntaphilin (bos taurus) (aka syntaphilin)
E: syntaphilin (rattus norvegicus) (aka syntaphilin)
F: None of the above. | A |
<Instruct>: Given the context 'Syntaxin-1 is a key component of the synaptic vesicle docking/fusion machinery that forms the SNARE complex with VAMP/synaptobrevin and SNAP-25.', select the correct biomedical concept corresponding to 'snap-25'. Answer using one of the provided options. | <Options>: A: snap-25 (bos taurus) (aka synaptosome associated protein 25)
B: snap-25 (mus musculus) (aka synaptosomal-associated protein 25)
C: synaptosome associated protein 25 (homo sapiens) (aka synaptosome associated protein 25)
D: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus ... | C |
<Instruct>: Given the context 'We have cloned and characterized a protein called syntaphilin that is selectively expressed in brain.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer using one of the provided options. | <Options>: A: syntaphilin (rattus norvegicus) (aka syntaphilin)
B: syntaphilin (bos taurus) (aka syntaphilin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
F: None of the a... | C |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer using one of the provided options. | <Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
D: syntaphilin (xenopus laevis) (aka syntaphilin l homeolog)
E: syntaphilin (hom... | E |
<Instruct>: Given the context 'Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits SNARE complex formation by absorbing free syntaxin-1.', select the correct biomedical concept corresponding to 'snap-25'. Answer using one of the provided options. | <Options>: A: snap25 (homo sapiens) (aka synaptosome associated protein 25)
B: snap-25 (xenopus laevis) (synaptosome associated protein 25kda s homeolog (xenopus laevis)) (aka synaptosome associated protein 25kda s homeolog)
C: snap-25 (bos taurus) (aka synaptosome associated protein 25)
D: snap-25 (xenopus tropicalis)... | A |
<Instruct>: Given the context 'Transient overexpression of syntaphilin in cultured hippocampal neurons significantly reduces neurotransmitter release.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer using one of the provided options. | <Options>: A: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syntaphilin (homo sapiens) (aka syntaphilin)
D: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
E: syntaphilin (xenopus tropical... | C |
<Instruct>: Given the context 'Furthermore, introduction of syntaphilin into presynaptic superior cervical ganglion neurons in culture inhibits synaptic transmission.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer using one of the provided options. | <Options>: A: syntaphilin (bos taurus) (aka syntaphilin)
B: syntaphilin (sus scrofa) (aka syntaphilin)
C: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syn (drosophila melanogaster) (synapsin (drosophila melanogaster)) (aka synapsin)
F: None of t... | D |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer usi... | <Options>: A: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntrophin-like 1)
B: syntaphilin (rattus norvegicus) (aka syntaphilin)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin (homo sapiens) (aka syntaphilin)
E: syn1 (drosophila melanogaster) (synapsin (drosophila me... | D |
<Instruct>: Given the context 'These findings suggest that syntaphilin may function as a molecular clamp that controls free syntaxin-1 availability for the assembly of the SNARE complex, and thereby regulates synaptic vesicle exocytosis.', select the correct biomedical concept corresponding to 'syntaphilin'. Answer usi... | <Options>: A: syntaphilin (sus scrofa) (aka syntaphilin)
B: syntaphilin (xenopus tropicalis) (aka syntaphilin)
C: syntaphilin (bos taurus) (aka syntaphilin)
D: syntaphilin s homeolog (xenopus laevis) (aka syntaphilin s homeolog)
E: syn1 (drosophila melanogaster) (syntrophin-like 1 (drosophila melanogaster)) (aka syntro... | F |
<Instruct>: Given the context 'Human follicle stimulating hormone receptor variants lacking transmembrane domains display altered post-translational conformations.
', select the correct biomedical concept corresponding to 'human follicle stimulating hormone receptor'. Answer using one of the provided options. | <Options>: A: follicle stimulating hormone receptor (rattus norvegicus) (aka follicle stimulating hormone receptor)
B: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
C: fshr (sus scrofa) (aka follicle stimulating hormone receptor)
D: gonadotropin releasing hormone recep... | B |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept corres... | <Options>: A: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
B: follicle stimulating hormone receptor (sus scrofa) (aka follicle stimulating hormone receptor)
C: follicle stimulating hormone receptor (xenopus tropicalis) (aka follicle stimulating hormone receptor)
D: fo... | A |
<Instruct>: Given the context 'To determine receptor variant trafficking and intracellular processing in mammalian cells, the intracellular fate of intentionally truncated variants of human follicle stimulating hormone receptor (hFSH-R) expressed in CHO cells was examined.', select the correct biomedical concept corres... | <Options>: A: thyroid stimulating hormone receptor (homo sapiens) (aka thyroid stimulating hormone receptor)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
D: ghr (homo sapiens) (aka growth hormone... | E |
<Instruct>: Given the context 'Epitope mapping using synthetic peptides, and truncated hFSH-R variants revealed that mAb 106.156 bound to ECD residues 183-220, while mAbs 106.318, 106.290, 106.263 bound ECD residues 300-331.', select the correct biomedical concept corresponding to 'hfsh-r'. Answer using one of the prov... | <Options>: A: ghrhr (homo sapiens) (aka growth hormone releasing hormone receptor)
B: ghr (homo sapiens) (aka growth hormone receptor)
C: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing... | C |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical co... | <Options>: A: ghr (homo sapiens) (aka growth hormone receptor)
B: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
C: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
D: growth hormone releasing hormone receptor (homo sapiens) (aka growth hormone releasing hormone receptor)
E: tshr (homo sa... | C |
<Instruct>: Given the context 'Immunofluorescence microscopy showed that mAbs 106.318 and 106.156 stained the surface of fixed, intact CHO cells expressing wild type hFSH-R. However, following cell permeabilization all four antibodies stained hFSH-R in Golgi and endoplasmic reticulum.', select the correct biomedical co... | <Options>: A: ghsr (homo sapiens) (aka growth hormone secretagogue receptor)
B: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: follicle stimulating hormone receptor (homo sapiens) (aka follicle stimulating hormo... | D |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept corresponding to 'hfsh-r'. Answer u... | <Options>: A: fshr (homo sapiens) (aka follicle stimulating hormone receptor)
B: tshr (homo sapiens) (aka thyroid stimulating hormone receptor)
C: ghr (homo sapiens) (aka growth hormone receptor)
D: gonadotropin releasing hormone receptor (homo sapiens) (aka gonadotropin releasing hormone receptor)
E: ghsr (homo sapien... | A |
<Instruct>: Given the context 'Both glycosylated truncated hFSH-R variants were sensitive to peptide-N-glycanase F and endoglycosidase H but insensitive to neuraminidase indicating that these variants possess high mannose type oligosaccharides.', select the correct biomedical concept corresponding to 'neuraminidase'. A... | <Options>: A: neuraminidase 1 (sus scrofa) (aka neuraminidase 1)
B: n-acetylneuraminic acid phosphatase (homo sapiens) (aka n-acetylneuraminic acid phosphatase)
C: neuraminidase 4 (homo sapiens) (aka neuraminidase 4)
D: neu (homo sapiens) (neuraminidase 1 (homo sapiens)) (aka neuraminidase 1)
E: neuraminidase 2 (homo s... | D |
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