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<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept corresponding to 'melanotransferrin'. Answer using one of the provided options.
<Options>: A: mtf (homo sapiens) (melanotransferrin (homo sapiens)) (aka melanotransferrin) B: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog) C: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin) D: melanotransferrin (mus musculus) (aka melanotransferrin) E: melanotransferrin (rattus norvegicus) (aka melanotransferrin) F: None of the above.
A
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1) B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like) C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein) D: map97 (homo sapiens) (aka melanotransferrin) E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) F: None of the above.
D
<Instruct>: Given the context 'Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence. p97 is a cell-surface glycoprotein that is present in most human melanomas but only in trace amounts in normal adult tissues.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like) B: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein) C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like) D: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1) E: p97 (bos taurus) (aka valosin containing protein) F: None of the above.
F
<Instruct>: Given the context 'To determine the structure of this tumor-associated antigen and to identify its functional domains, we have purified and cloned p97 mRNA and determined its nucleotide sequence.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein) B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) C: map97 (homo sapiens) (aka melanotransferrin) D: p97 (bos taurus) (aka valosin containing protein) E: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94) F: None of the above.
C
<Instruct>: Given the context 'The mRNA encodes a 738-residue precursor, which contains the previously determined N-terminal amino acid sequence of p97.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein) B: p97 (bos taurus) (aka valosin containing protein) C: map97 (homo sapiens) (aka melanotransferrin) D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94) E: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like) F: None of the above.
C
<Instruct>: Given the context 'After removal of a 19-residue signal peptide, the mature p97 molecule comprises extracellular domains of 342 and 352 residues and a C-terminal 25-residue stretch of predominantly uncharged and hydrophobic amino acids, which we believe acts as a membrane anchor.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: map97 (homo sapiens) (aka melanotransferrin) B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) C: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94) D: hspc97 (homo sapiens) (aka tubulin gamma complex component 2) E: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1) F: None of the above.
A
<Instruct>: Given the context 'Protease digestion studies show that the three major antigenic determinants of p97 are present on the N-terminal domain.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: map97 (homo sapiens) (aka melanotransferrin) B: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like) C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like) D: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2) F: None of the above.
A
<Instruct>: Given the context 'The domains are strikingly homologous to each other (46% amino acid sequence homology) and to the corresponding domains of human serum transferrin (39% homology).', select the correct biomedical concept corresponding to 'transferrin'. Answer using one of the provided options.
<Options>: A: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin) B: tfrc (homo sapiens) (aka transferrin receptor) C: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1) D: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin)) E: tfrc (gallus gallus) (aka transferrin receptor) F: None of the above.
A
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: hspc97 (homo sapiens) (aka tubulin gamma complex component 2) B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like) C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94) E: map97 (homo sapiens) (aka melanotransferrin) F: None of the above.
E
<Instruct>: Given the context 'Conservation of disulfide bridges and of amino acids thought to compose the iron binding pockets suggests that p97 is also related to transferrin in tertiary structure and function.', select the correct biomedical concept corresponding to 'transferrin'. Answer using one of the provided options.
<Options>: A: tfr (homo sapiens) (aka transferrin receptor) B: tfrc (gallus gallus) (aka transferrin receptor) C: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin)) D: transferrin (homo sapiens) (aka transferrin) E: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1) F: None of the above.
D
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options.
<Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2) B: p97 (bos taurus) (aka valosin containing protein) C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like) D: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94) E: map97 (homo sapiens) (aka melanotransferrin) F: None of the above.
E
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'melanotransferrin'. Answer using one of the provided options.
<Options>: A: melanotransferrin (homo sapiens) (aka melanotransferrin) B: melanotransferrin (oryctolagus cuniculus) (aka melanotransferrin) C: melanotransferrinl homeolog (xenopus laevis) (aka melanotransferrinl homeolog) D: melanotransferrin (rattus norvegicus) (aka melanotransferrin) E: melanotransferrin (gallus gallus) (aka melanotransferrin) F: None of the above.
A
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'serotransferrin'. Answer using one of the provided options.
<Options>: A: transferrin receptor (homo sapiens) (aka transferrin receptor) B: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin) C: serotransferrin (glycine max) (aka serotransferrin) D: otoferlin (homo sapiens) (aka otoferlin) E: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin)) F: None of the above.
B
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'serotransferrin'. Answer using one of the provided options.
<Options>: A: lactotransferrin (homo sapiens) (aka lactotransferrin) B: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin)) C: transferrin receptor (homo sapiens) (aka transferrin receptor) D: lactotransferrin (sus scrofa) (aka lactotransferrin) E: hemiferrin, transferrin-like protein (rattus norvegicus) (aka hemiferrin, transferrin-like protein) F: None of the above.
F
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'lactotransferrin'. Answer using one of the provided options.
<Options>: A: lactoferrin (xenopus tropicalis) (aka transferrin) B: lactotransferrin (rattus norvegicus) (aka lactotransferrin) C: ferritin light chain (homo sapiens) (aka ferritin light chain) D: lactotransferrin (homo sapiens) (aka lactotransferrin) E: lactoferrin (xenopus laevis) (transferrin s homeolog (xenopus laevis)) (aka transferrin s homeolog) F: None of the above.
D
<Instruct>: Given the context 'We propose that p97 be renamed melanotransferrin to denote its original identification in melanoma cells and its evolutionary relationship to serotransferrin and lactotransferrin, the other members of the transferrin superfamily.', select the correct biomedical concept corresponding to 'transferrin'. Answer using one of the provided options.
<Options>: A: tf (homo sapiens) (transferrin (homo sapiens)) (aka transferrin) B: tfr1 (homo sapiens) (aka transferrin receptor) C: tf (drosophila melanogaster) (transferrin 1 (drosophila melanogaster)) (aka transferrin 1) D: transferrin (ovotransferrin) (gallus gallus) (aka transferrin (ovotransferrin)) E: transferrin receptor (gallus gallus) (aka transferrin receptor) F: None of the above.
A
<Instruct>: Given the context 'Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase. ', select the correct biomedical concept corresponding to 'calcineurin b'. Answer using one of the provided options.
<Options>: A: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha) B: ppp3cb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta) C: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit) D: protein phosphatase 3 regulatory subunit b, beta (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, beta) E: can (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b) F: None of the above.
A
<Instruct>: Given the context 'We have identified and cloned human cDNA for the Ca2+-binding subunit of calcineurin, the brain isozyme of the Ca2+/calmodulin-stimulated protein phosphatase.', select the correct biomedical concept corresponding to 'ca2+-binding subunit of calcineurin'. Answer using one of the provided options.
<Options>: A: cngb1 (xenopus tropicalis) (aka cyclic nucleotide gated channel beta 1) B: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta) C: calna1 (homo sapiens) (aka protein phosphatase 3 catalytic subunit alpha) D: cngb1 (homo sapiens) (aka cyclic nucleotide gated channel subunit beta 1) E: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha) F: None of the above.
E
<Instruct>: Given the context 'The deduced sequence of the human protein differs from bovine brain calcineurin B by an additional valine at the carboxyl terminus and substitution of Met-11 and Ser-153 by cysteine.', select the correct biomedical concept corresponding to 'calcineurin b'. Answer using one of the provided options.
<Options>: A: cnb (drosophila melanogaster) (calcineurin b (drosophila melanogaster)) (aka calcineurin b) B: ppp3cb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta) C: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b) D: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha) E: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit) F: None of the above.
D
<Instruct>: Given the context 'As was observed with protein levels, mRNA abundance in brain is 20-60 times that found in other tissues with the exception of HeLa cells which, like brain, contain abundant calcineurin B mRNA.', select the correct biomedical concept corresponding to 'calcineurin b'. Answer using one of the provided options.
<Options>: A: scnn1b-b (xenopus tropicalis) (aka sodium channel, non voltage gated 1 beta subunit) B: calnb (homo sapiens) (aka protein phosphatase 3 catalytic subunit beta) C: cnb (homo sapiens) (aka protein phosphatase 3 regulatory subunit b, alpha) D: prkcbb (xenopus tropicalis) (aka protein kinase c beta) E: pp2cbeta (homo sapiens) (aka protein phosphatase, mg2+/mn2+ dependent 1b) F: None of the above.
C
<Instruct>: Given the context 'Human liver serine dehydratase.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase) B: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like) C: serine dehydratase (bos taurus) (aka serine dehydratase) D: serine dehydratase like (homo sapiens) (aka serine dehydratase like) E: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase) F: None of the above.
A
<Instruct>: Given the context 'Rat liver serine dehydratase cDNA was used to screen a human liver cDNA library in lambda gt11.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: serine dehydratase (xenopus tropicalis) (aka serine dehydratase) B: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog) C: serine dehydratase (homo sapiens) (aka serine dehydratase) D: serine dehydratase (bos taurus) (aka serine dehydratase) E: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like) F: None of the above.
F
<Instruct>: Given the context 'The deduced amino acid sequence, with a calculated Mr of 34,615, was similar to that of rat liver serine dehydratase except for the absence of a segment consisting of 36 amino acid residues.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: serine dehydratase like (bos taurus) (aka serine dehydratase like) B: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog) C: serine dehydratase like (homo sapiens) (aka serine dehydratase like) D: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like) E: serine dehydratase (sus scrofa) (aka serine dehydratase) F: None of the above.
F
<Instruct>: Given the context 'In vitro transcription/translation with the cDNA resulted in the formation of a polypeptide with an Mr of approximately 35,000, which cross-reacted with the anti-rat serine dehydratase antibody.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: serine dehydratase like (homo sapiens) (aka serine dehydratase like) B: serine dehydratase (bos taurus) (aka serine dehydratase) C: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog) D: sds (homo sapiens) (serine dehydratase (homo sapiens)) (aka serine dehydratase) E: serine dehydratase (xenopus tropicalis) (aka serine dehydratase) F: None of the above.
F
<Instruct>: Given the context 'In vitro transcription/translation with the cDNA resulted in the formation of a polypeptide with an Mr of approximately 35,000, which cross-reacted with the anti-rat serine dehydratase antibody.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: serine dehydratase (homo sapiens) (aka serine dehydratase) B: serine dehydratase (bos taurus) (aka serine dehydratase) C: serine dehydratase (sus scrofa) (aka serine dehydratase) D: serine dehydratase like (bos taurus) (aka serine dehydratase like) E: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like) F: None of the above.
F
<Instruct>: Given the context 'These results suggest that the human serine dehydratase is structurally cognate with the rat enzyme.', select the correct biomedical concept corresponding to 'serine dehydratase'. Answer using one of the provided options.
<Options>: A: serine dehydratase like (xenopus tropicalis) (aka serine dehydratase like) B: serine dehydratase (xenopus tropicalis) (aka serine dehydratase) C: serine dehydratase s homeolog (xenopus laevis) (aka serine dehydratase s homeolog) D: serine dehydratase (oryctolagus cuniculus) (aka serine dehydratase) E: serine dehydratase (homo sapiens) (aka serine dehydratase) F: None of the above.
E
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) B: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1) C: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1) D: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) E: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) F: None of the above.
B
<Instruct>: Given the context 'rac1 and rac2 cDNA clones were isolated from a differentiated HL-60 library and encode proteins that are 92% homologous and share 58% and 26-30% amino acid homology with human rhos and ras, respectively.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2) B: rac2 (homo sapiens) (aka rac family small gtpase 2) C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) D: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) E: rac (homo sapiens) (aka akt serine/threonine kinase 1) F: None of the above.
B
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1) B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) D: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) E: p21-rac1 (homo sapiens) (aka rac family small gtpase 1) F: None of the above.
E
<Instruct>: Given the context 'Nucleotide sequence analysis predicts both rac1 and rac2 proteins to contain 192 amino acids with molecular masses of 21,450 and 21,429 daltons, respectively.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) B: rac (homo sapiens) (aka akt serine/threonine kinase 1) C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) D: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2) E: p21-rac2 (homo sapiens) (aka rac family small gtpase 2) F: None of the above.
E
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) B: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) D: rac gtpase (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1) E: p21-rac1 (homo sapiens) (aka rac family small gtpase 1) F: None of the above.
E
<Instruct>: Given the context 'rac1 and rac2 possess four of the five conserved functional domains in ras associated with binding and hydrolysis of guanine nucleotides.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) C: rac (homo sapiens) (aka akt serine/threonine kinase 1) D: rac2 (homo sapiens) (aka rac family small gtpase 2) E: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2) F: None of the above.
D
<Instruct>: Given the context 'The rac transcripts, particularly rac2, display relative myeloid tissue selectivity.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac (homo sapiens) (aka akt serine/threonine kinase 1) B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) C: akt2 (homo sapiens) (aka akt serine/threonine kinase 2) D: rac2 (homo sapiens) (aka rac family small gtpase 2) E: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) F: None of the above.
D
<Instruct>: Given the context 'Both rac1 transcripts (2.4 and 1.1 kilobases (kb] increase when HL-60 cells differentiate to neutrophil-like morphology.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1) B: rac family small gtpase 1 (homo sapiens) (aka rac family small gtpase 1) C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) D: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) E: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) F: None of the above.
B
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: akt2 (homo sapiens) (aka akt serine/threonine kinase 2) B: p21-rac2 (homo sapiens) (aka rac family small gtpase 2) C: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) D: rac (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) E: rac (homo sapiens) (aka akt serine/threonine kinase 1) F: None of the above.
B
<Instruct>: Given the context 'rac2 mRNA (1.45 kb) increases 7-9-fold and 3-fold upon differentiation of HL-60 and U937 cells, respectively.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2) B: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) C: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) D: rac (homo sapiens) (aka akt serine/threonine kinase 1) E: None of the above.
E
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) B: p21-rac1 (homo sapiens) (aka rac family small gtpase 1) C: rac1 (drosophila melanogaster) (gtpase rac1 (drosophila melanogaster)) (aka rac1) D: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) E: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) F: None of the above.
B
<Instruct>: Given the context 'Neither rac mRNAs are present in a Jurkat T cell line, and unlike rac1, rac2 mRNA is absent in human brain and liver tissue.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) B: akt2 (homo sapiens) (aka akt serine/threonine kinase 2) C: rac2 (homo sapiens) (aka rac family small gtpase 2) D: rac (homo sapiens) (aka akt serine/threonine kinase 1) E: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) F: None of the above.
C
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept corresponding to 'rac1'. Answer using one of the provided options.
<Options>: A: rac1l (rattus norvegicus) (aka rac family small gtpase 1 like) B: rac1 (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) C: rac1p1 (homo sapiens) (aka rac family small gtpase 1 pseudogene 1) D: rac (drosophila melanogaster) (rac1 (drosophila melanogaster)) (aka rac1) E: rac1 (homo sapiens) (rac family small gtpase 1 (homo sapiens)) (aka rac family small gtpase 1) F: None of the above.
E
<Instruct>: Given the context 'Transfection experiments permitted the demonstration that rac1 and rac2 are substrates for ADP-ribosylation by the C3 component of botulinum toxin.', select the correct biomedical concept corresponding to 'rac2'. Answer using one of the provided options.
<Options>: A: rach2 (homo sapiens) (aka solute carrier family 14 member 1 (kidd blood group)) B: rac gtpase (drosophila melanogaster) (rac2 (drosophila melanogaster)) (aka rac2) C: rac (homo sapiens) (aka akt serine/threonine kinase 1) D: rac-beta (homo sapiens) (aka akt serine/threonine kinase 2) E: rac2 (homo sapiens) (aka rac family small gtpase 2) F: None of the above.
E
<Instruct>: Given the context 'Human gastric cathepsin E. Predicted sequence, localization to chromosome 1, and sequence homology with other aspartic proteinases. ', select the correct biomedical concept corresponding to 'cathepsin e'. Answer using one of the provided options.
<Options>: A: cathepsin e (mus musculus) (aka cathepsin e) B: cathepsin e (rattus norvegicus) (aka cathepsin e) C: carboxypeptidase e (gallus gallus) (aka carboxypeptidase e) D: cathepsin e (homo sapiens) (aka cathepsin e) E: cathepsin c (homo sapiens) (aka cathepsin c) F: None of the above.
D
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept corresponding to 'cathepsin e'. Answer using one of the provided options.
<Options>: A: cathepsin e (gallus gallus) (aka cathepsin e) B: peptidase e (homo sapiens) (aka peptidase e) C: cathepsin e (mus musculus) (aka cathepsin e) D: cathepsin c (homo sapiens) (aka cathepsin c) E: ctse (homo sapiens) (aka cathepsin e) F: None of the above.
E
<Instruct>: Given the context 'The predicted sequence of human gastric cathepsin E (CTSE) was determined by analysis of cDNA clones isolated from a library constructed with poly(A+) RNA from a gastric adenocarcinoma cell line.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctse (gallus gallus) (aka cathepsin e) B: ctsh (homo sapiens) (aka cathepsin h) C: ctse (rattus norvegicus) (aka cathepsin e) D: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) E: ctse (homo sapiens) (aka cathepsin e) F: None of the above.
E
<Instruct>: Given the context 'The CTSE cDNA clones were identified using a set of complementary 18-base oligonucleotide probes specific for a 6-residue sequence surrounding the first active site of all previously characterized human aspartic proteinases.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: cathepsin e (homo sapiens) (aka cathepsin e) B: ctsa (homo sapiens) (aka cathepsin a) C: ctsl (homo sapiens) (aka cathepsin l) D: ctse (rattus norvegicus) (aka cathepsin e) E: ctse (mus musculus) (aka cathepsin e) F: None of the above.
A
<Instruct>: Given the context 'Sequence analysis of CTSE cDNA clones revealed a 1188-base pair open reading frame that exhibited 59% sequence identity with human pepsinogen A.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctsa (homo sapiens) (aka cathepsin a) B: cathepsin e (homo sapiens) (aka cathepsin e) C: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog) D: ctse (mus musculus) (aka cathepsin e) E: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) F: None of the above.
B
<Instruct>: Given the context 'The predicted CTSE amino acid sequence includes a 379-residue proenzyme (Mr = 40,883) and a 17-residue signal peptide.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctse (homo sapiens) (aka cathepsin e) B: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog) C: ctse (mus musculus) (aka cathepsin e) D: ctse (gallus gallus) (aka cathepsin e) E: ctsh (homo sapiens) (aka cathepsin h) F: None of the above.
A
<Instruct>: Given the context 'The predicted CTSE amino acid sequence includes a 379-residue proenzyme (Mr = 40,883) and a 17-residue signal peptide.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctsl (homo sapiens) (aka cathepsin l) B: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) C: ctsh (homo sapiens) (aka cathepsin h) D: ctse (mus musculus) (aka cathepsin e) E: ctse (rattus norvegicus) (aka cathepsin e) F: None of the above.
F
<Instruct>: Given the context 'The predicted CTSE amino acid composition was consistent with that of purified material from gastric mucosa and gastric adenocarcinoma cell lines.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: cathepsin e (homo sapiens) (aka cathepsin e) B: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog) C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) D: ctse (gallus gallus) (aka cathepsin e) E: ctsa (homo sapiens) (aka cathepsin a) F: None of the above.
A
<Instruct>: Given the context 'Additional evidence for the identification of the CTSE cDNA clones was obtained by analysis of poly(A+) RNA isolated from CTSE-producing and -nonproducing gastric adenocarcinoma cell subclones.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctse (gallus gallus) (aka cathepsin e) B: ctse (rattus norvegicus) (aka cathepsin e) C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) D: ctsl (homo sapiens) (aka cathepsin l) E: cathepsin e (homo sapiens) (aka cathepsin e) F: None of the above.
E
<Instruct>: Given the context 'Additional evidence for the identification of the CTSE cDNA clones was obtained by analysis of poly(A+) RNA isolated from CTSE-producing and -nonproducing gastric adenocarcinoma cell subclones.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctse (gallus gallus) (aka cathepsin e) B: cathepsin e (homo sapiens) (aka cathepsin e) C: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) D: ctsa (homo sapiens) (aka cathepsin a) E: ctsh (homo sapiens) (aka cathepsin h) F: None of the above.
B
<Instruct>: Given the context 'Three RNA transcripts (3.6, 2.6, and 2.1 kilobases) were identified in poly(A+) RNA isolated from a gastric adenocarcinoma cell line that produced CTSE that were absent from nonproducing subclones.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) B: cathepsin e (homo sapiens) (aka cathepsin e) C: ctsh (homo sapiens) (aka cathepsin h) D: ctse (mus musculus) (aka cathepsin e) E: ctsl (homo sapiens) (aka cathepsin l) F: None of the above.
B
<Instruct>: Given the context 'CTSE contains 7 cysteine residues, of which 6 were localized by comparative maximal alignment analysis with pepsinogen A to conserved residues that form intrachain disulfide bonds.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: cathepsin e (homo sapiens) (aka cathepsin e) B: ctsh (homo sapiens) (aka cathepsin h) C: ctsl (homo sapiens) (aka cathepsin l) D: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) E: ctse (mus musculus) (aka cathepsin e) F: None of the above.
A
<Instruct>: Given the context 'The seventh cysteine residue of CTSE is located within the activation peptide region of the proenzyme.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctsh (homo sapiens) (aka cathepsin h) B: ctse (mus musculus) (aka cathepsin e) C: ctse (homo sapiens) (aka cathepsin e) D: carboxypeptidase e (homo sapiens) (aka carboxypeptidase e) E: ctse (gallus gallus) (aka cathepsin e) F: None of the above.
C
<Instruct>: Given the context 'We suspect that this residue forms an interchain disulfide bond and thereby determines the dimerization of CTSE proenzyme molecules that is observed under native conditions.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctsa (homo sapiens) (aka cathepsin a) B: ctse (rattus norvegicus) (aka cathepsin e) C: ctsl (homo sapiens) (aka cathepsin l) D: ctse (xenopus laevis) (cathepsin e s homeolog (xenopus laevis)) (aka cathepsin e s homeolog) E: ctse (homo sapiens) (aka cathepsin e) F: None of the above.
E
<Instruct>: Given the context 'The CTSE gene was localized to human chromosome 1 by concurrent cytogenetic and cDNA probe analyses of a panel of human x mouse somatic cell hybrids.', select the correct biomedical concept corresponding to 'ctse'. Answer using one of the provided options.
<Options>: A: ctse (mus musculus) (aka cathepsin e) B: ctse (homo sapiens) (aka cathepsin e) C: ctsl (homo sapiens) (aka cathepsin l) D: ctsa (homo sapiens) (aka cathepsin a) E: ctsh (homo sapiens) (aka cathepsin h) F: None of the above.
B
<Instruct>: Given the context 'Homology between a region of the human retinoblastoma gene and L1 family repetitive sequences. ', select the correct biomedical concept corresponding to 'retinoblastoma'. Answer using one of the provided options.
<Options>: A: rb-1 (homo sapiens) (aka rna binding motif protein 45) B: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2) C: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) D: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1) E: rb1 (homo sapiens) (aka rb transcriptional corepressor 1) F: None of the above.
E
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept corresponding to 'retinoblastoma'. Answer using one of the provided options.
<Options>: A: rb (homo sapiens) (aka rb transcriptional corepressor 1) B: rb3 (homo sapiens) (aka stathmin 4) C: rbb (homo sapiens) (aka nacc family member 2) D: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1) E: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) F: None of the above.
A
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept corresponding to 'retinoblastoma'. Answer using one of the provided options.
<Options>: A: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1) B: rbb (homo sapiens) (aka nacc family member 2) C: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) D: rb (drosophila melanogaster) (retinoblastoma-family protein 2 (drosophila melanogaster)) (aka retinoblastoma-family protein 2) E: rb-1 (homo sapiens) (aka rna binding motif protein 45) F: None of the above.
F
<Instruct>: Given the context 'Five clones that hybridized weakly with the human retinoblastoma (Rb) gene were obtained by screening a human genomic library in a non-stringent condition.', select the correct biomedical concept corresponding to 'rb'. Answer using one of the provided options.
<Options>: A: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2) B: rb1 (homo sapiens) (aka rb transcriptional corepressor 1) C: rb-1 (homo sapiens) (aka rna binding motif protein 45) D: rb3 (homo sapiens) (aka stathmin 4) E: rbb (homo sapiens) (aka nacc family member 2) F: None of the above.
B
<Instruct>: Given the context 'The DNAs of two of these clones were partially sequenced and found to contain a region with considerable homology to part of the Rb gene.', select the correct biomedical concept corresponding to 'rb'. Answer using one of the provided options.
<Options>: A: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1) B: rb3 (homo sapiens) (aka stathmin 4) C: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) D: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2) E: prb (homo sapiens) (aka rb transcriptional corepressor 1) F: None of the above.
E
<Instruct>: Given the context 'As the L1 family is transposable, the Rb gene may be inactivated by recombination at this homologous region.', select the correct biomedical concept corresponding to 'rb'. Answer using one of the provided options.
<Options>: A: rb (homo sapiens) (aka rb transcriptional corepressor 1) B: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) C: rbb (homo sapiens) (aka nacc family member 2) D: rb3 (homo sapiens) (aka stathmin 4) E: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2) F: None of the above.
A
<Instruct>: Given the context 'Another possibility related with the DNA binding properties of Rb and L1 family proteins is also discussed.', select the correct biomedical concept corresponding to 'rb'. Answer using one of the provided options.
<Options>: A: rb-1 (homo sapiens) (aka rna binding motif protein 45) B: p105-rb (homo sapiens) (aka rb transcriptional corepressor 1) C: rbl1 (homo sapiens) (aka rb transcriptional corepressor like 1) D: rb (drosophila melanogaster) (retinoblastoma-family protein (drosophila melanogaster)) (aka retinoblastoma-family protein) E: rb2 (homo sapiens) (aka rb transcriptional corepressor like 2) F: None of the above.
B
<Instruct>: Given the context 'COUP transcription factor is a member of the steroid receptor superfamily. ', select the correct biomedical concept corresponding to 'coup transcription factor'. Answer using one of the provided options.
<Options>: A: coup-tf (bos taurus) (aka nuclear receptor subfamily 2 group f member 1) B: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1) C: coup1 (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 2) D: couptf1 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) E: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 l homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 l homeolog) F: None of the above.
D
<Instruct>: Given the context 'The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene.', select the correct biomedical concept corresponding to 'coup (chicken ovalbumin upstream promoter) transcription factor'. Answer using one of the provided options.
<Options>: A: coup-tf (bos taurus) (aka nuclear receptor subfamily 2 group f member 1) B: coup-tfi (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) C: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 l homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 l homeolog) D: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 s homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 s homeolog) E: coup1 (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 2) F: None of the above.
B
<Instruct>: Given the context 'The COUP (chicken ovalbumin upstream promoter) transcription factor (COUP-TF) exists in a number of different tissues and is essential for expression of the chicken ovalbumin gene.', select the correct biomedical concept corresponding to 'coup-tf'. Answer using one of the provided options.
<Options>: A: couptf1 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) B: couptfb (homo sapiens) (aka nuclear receptor subfamily 2 group f member 2) C: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5) D: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1) E: coup-tfi (bos taurus) (aka nuclear receptor subfamily 2 group f member 1) F: None of the above.
A
<Instruct>: Given the context 'COUP-TF also binds specifically to the rat insulin promoter element, although the two binding sites share little sequence similarity.', select the correct biomedical concept corresponding to 'coup-tf'. Answer using one of the provided options.
<Options>: A: coup-tfi (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) B: couptfb (homo sapiens) (aka nuclear receptor subfamily 2 group f member 2) C: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5) D: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1) E: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1) F: None of the above.
A
<Instruct>: Given the context 'Here we report the isolation of a human complementary DNA clone encoding COUP-TF.', select the correct biomedical concept corresponding to 'coup-tf'. Answer using one of the provided options.
<Options>: A: couptf1 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) B: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1) C: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5) D: coup-tfii (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 2) E: coup-tf (bos taurus) (aka nuclear receptor subfamily 2 group f member 1) F: None of the above.
A
<Instruct>: Given the context 'Comparison of the amino-acid sequence of COUP-TF with known sequences reveals that it is a member of the steroid/thyroid hormone/vitamin receptor superfamily.', select the correct biomedical concept corresponding to 'coup-tf'. Answer using one of the provided options.
<Options>: A: coup-tfi (bos taurus) (aka nuclear receptor subfamily 2 group f member 1) B: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5) C: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1) D: couptf1 (homo sapiens) (aka nuclear receptor subfamily 2 group f member 1) E: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1) F: None of the above.
D
<Instruct>: Given the context 'Comparison of the amino-acid sequence of COUP-TF with known sequences reveals that it is a member of the steroid/thyroid hormone/vitamin receptor superfamily.', select the correct biomedical concept corresponding to 'coup-tf'. Answer using one of the provided options.
<Options>: A: coup-tfi (rattus norvegicus) (aka nuclear receptor subfamily 2, group f, member 1) B: coup-tfa (xenopus tropicalis) (aka nuclear receptor subfamily 2, group f, member 5) C: coup (xenopus laevis) (nuclear receptor subfamily 2, group f, member 5 l homeolog (xenopus laevis)) (aka nuclear receptor subfamily 2, group f, member 5 l homeolog) D: couptfb (homo sapiens) (aka nuclear receptor subfamily 2 group f member 2) E: coup-tfi (xenopus tropicalis) (aka nuclear receptor subfamily 2 group f member 1) F: None of the above.
F
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'interleukin-2 receptor beta'. Answer using one of the provided options.
<Options>: A: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) B: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) C: interleukin 20 receptor subunit beta (homo sapiens) (aka interleukin 20 receptor subunit beta) D: il22r (homo sapiens) (aka interleukin 22 receptor subunit alpha 1) E: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) F: None of the above.
B
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'interleukin-2'. Answer using one of the provided options.
<Options>: A: fgf-2 (homo sapiens) (aka fibroblast growth factor 2) B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2) C: ilf2 (homo sapiens) (aka interleukin enhancer binding factor 2) D: il22 (homo sapiens) (aka interleukin 22) E: il-2 (homo sapiens) (aka interleukin 2) F: None of the above.
E
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options.
<Options>: A: interleukin 3 (homo sapiens) (aka interleukin 3) B: colony stimulating factor 2 (homo sapiens) (aka colony stimulating factor 2) C: il2 (homo sapiens) (aka interleukin 2) D: fgf-2 (homo sapiens) (aka fibroblast growth factor 2) E: il22 (homo sapiens) (aka interleukin 22) F: None of the above.
C
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'il-2 receptor alpha'. Answer using one of the provided options.
<Options>: A: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha) B: il22ra2 (homo sapiens) (aka interleukin 22 receptor subunit alpha 2) C: il22r (homo sapiens) (aka interleukin 22 receptor subunit alpha 1) D: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) E: colony stimulating factor 2 receptor subunit alpha (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) F: None of the above.
A
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'il-2r alpha'. Answer using one of the provided options.
<Options>: A: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta) B: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma) C: colony stimulating factor 2 receptor subunit alpha (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) D: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2) E: interleukin 2 receptor subunit alpha (homo sapiens) (aka interleukin 2 receptor subunit alpha) F: None of the above.
E
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'p55'. Answer using one of the provided options.
<Options>: A: d55 (homo sapiens) (aka tpd52 like 3) B: p55 (drosophila melanogaster) (regulatory particle non-atpase 5 (drosophila melanogaster)) (aka regulatory particle non-atpase 5) C: znf555 (homo sapiens) (aka zinc finger protein 555) D: p55t (homo sapiens) (aka protein associated with lin7 2, maguk p55 family member) E: p55-r (homo sapiens) (aka tnf receptor superfamily member 1a) F: None of the above.
F
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'il-2 receptor beta'. Answer using one of the provided options.
<Options>: A: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) B: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2) C: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) D: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta) E: il22r (homo sapiens) (aka interleukin 22 receptor subunit alpha 1) F: None of the above.
D
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'il-2r beta'. Answer using one of the provided options.
<Options>: A: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) B: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2) C: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1) D: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma) E: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta) F: None of the above.
E
<Instruct>: Given the context 'Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's. Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor alpha (IL-2R alpha, p55) chain and the newly identified IL-2 receptor beta (IL-2R beta, p70-75) chain.', select the correct biomedical concept corresponding to 'p70-75'. Answer using one of the provided options.
<Options>: A: pp75 (homo sapiens) (aka rab11 family interacting protein 5) B: hsp 75 (homo sapiens) (aka tnf receptor associated protein 1) C: pp8875 (homo sapiens) (aka rab, member ras oncogene family like 6) D: p70-75 (homo sapiens) (aka interleukin 2 receptor subunit beta) E: rpl7ap75 (homo sapiens) (aka ribosomal protein l7a pseudogene 75) F: None of the above.
D
<Instruct>: Given the context 'The cDNA encoding the human IL-2R beta chain has now been isolated.', select the correct biomedical concept corresponding to 'il-2r beta'. Answer using one of the provided options.
<Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma) B: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) C: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) D: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2) E: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) F: None of the above.
B
<Instruct>: Given the context 'The cDNA encoding the human IL-2R beta chain has now been isolated.', select the correct biomedical concept corresponding to 'il-2r beta'. Answer using one of the provided options.
<Options>: A: interleukin 12 receptor subunit beta 2 (homo sapiens) (aka interleukin 12 receptor subunit beta 2) B: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha) C: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) D: colony stimulating factor 2 receptor subunit beta (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) E: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma) F: None of the above.
F
<Instruct>: Given the context 'The overall primary structure of the IL-2R beta chain shows no apparent homology to other known receptors.', select the correct biomedical concept corresponding to 'il-2r beta'. Answer using one of the provided options.
<Options>: A: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1) B: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) C: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta) D: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha) E: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) F: None of the above.
C
<Instruct>: Given the context 'Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied.', select the correct biomedical concept corresponding to 'il-2r alpha'. Answer using one of the provided options.
<Options>: A: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2) B: cd132 (homo sapiens) (aka interleukin 2 receptor subunit gamma) C: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) D: il2ra (homo sapiens) (aka interleukin 2 receptor subunit alpha) E: colony stimulating factor 2 receptor subunit alpha (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) F: None of the above.
D
<Instruct>: Given the context 'Unlike the IL-2R alpha chain, the IL-2R beta chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied.', select the correct biomedical concept corresponding to 'il-2r beta'. Answer using one of the provided options.
<Options>: A: csf2rb2 (homo sapiens) (aka csf2rb pseudogene 1) B: csf2rb (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) C: il12rb (homo sapiens) (aka interleukin 12 receptor subunit beta 1) D: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma) E: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) F: None of the above.
E
<Instruct>: Given the context 'The cDNA-encoded beta chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells.', select the correct biomedical concept corresponding to 'il-2'. Answer using one of the provided options.
<Options>: A: il22 (homo sapiens) (aka interleukin 22) B: il-2 (homo sapiens) (aka interleukin 2) C: interleukin enhancer binding factor 2 (homo sapiens) (aka interleukin enhancer binding factor 2) D: interleukin 3 (homo sapiens) (aka interleukin 3) E: fgf-2 (homo sapiens) (aka fibroblast growth factor 2) F: None of the above.
B
<Instruct>: Given the context 'Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA.', select the correct biomedical concept corresponding to 'il-2 receptor'. Answer using one of the provided options.
<Options>: A: interleukin 2 receptor subunit gamma (homo sapiens) (aka interleukin 2 receptor subunit gamma) B: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2) C: interleukin 2 receptor subunit beta (homo sapiens) (aka interleukin 2 receptor subunit beta) D: il22r (homo sapiens) (aka interleukin 22 receptor subunit alpha 1) E: colony stimulating factor 2 receptor subunit beta (homo sapiens) (aka colony stimulating factor 2 receptor subunit beta) F: None of the above.
C
<Instruct>: Given the context 'Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2R alpha chain cDNA.', select the correct biomedical concept corresponding to 'il-2r alpha'. Answer using one of the provided options.
<Options>: A: interleukin 1 receptor type 2 (homo sapiens) (aka interleukin 1 receptor type 2) B: il-2rg (homo sapiens) (aka interleukin 2 receptor subunit gamma) C: il2r (homo sapiens) (aka interleukin 2 receptor subunit alpha) D: il2rb (homo sapiens) (aka interleukin 2 receptor subunit beta) E: colony stimulating factor 2 receptor subunit alpha (homo sapiens) (aka colony stimulating factor 2 receptor subunit alpha) F: None of the above.
C
<Instruct>: Given the context 'Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. ', select the correct biomedical concept corresponding to 'ldl receptor'. Answer using one of the provided options.
<Options>: A: apolipoprotein b receptor (homo sapiens) (aka apolipoprotein b receptor) B: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor) C: low density lipoprotein receptor (sus scrofa) (aka low density lipoprotein receptor) D: ldlr (homo sapiens) (aka low density lipoprotein receptor) E: very low density lipoprotein receptor (homo sapiens) (aka very low density lipoprotein receptor) F: None of the above.
D
<Instruct>: Given the context 'The pathogenesis of Heymann nephritis, a rat model of human membranous glomerulonephritis, depends on the interaction of autoantibodies with a renal glycoprotein (GP330) on glomerular podocytes.', select the correct biomedical concept corresponding to 'gp330'. Answer using one of the provided options.
<Options>: A: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 l homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 l homeolog) B: gp330 (homo sapiens) (aka ldl receptor related protein 2) C: gp43 (xenopus laevis) (provisional ortholog of zona pellucida glycoprotein 3 s homeolog (xenopus laevis)) (aka provisional ortholog of zona pellucida glycoprotein 3 s homeolog) D: gp340 (homo sapiens) (aka deleted in malignant brain tumors 1) E: gp330 (mus musculus) (aka low density lipoprotein receptor-related protein 2) F: None of the above.
B
<Instruct>: Given the context 'Partial complementary DNAs coding for GP330 were isolated and sequenced.', select the correct biomedical concept corresponding to 'gp330'. Answer using one of the provided options.
<Options>: A: gp340 (xenopus tropicalis) (aka deleted in malignant brain tumors 1) B: gp330 (homo sapiens) (aka ldl receptor related protein 2) C: gp330 (xenopus laevis) (aka ldl receptor related protein 2 l homeolog) D: gp43 (xenopus laevis) (provisional ortholog of zona pellucida glycoprotein 3 s homeolog (xenopus laevis)) (aka provisional ortholog of zona pellucida glycoprotein 3 s homeolog) E: gp330 (xenopus tropicalis) (aka ldl receptor related protein 2) F: None of the above.
B
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept corresponding to 'low density lipoprotein (ldl) receptor'. Answer using one of the provided options.
<Options>: A: oxidized low density lipoprotein receptor 1 (homo sapiens) (aka oxidized low density lipoprotein receptor 1) B: lrp1 (homo sapiens) (ldl receptor related protein 1 (homo sapiens)) (aka ldl receptor related protein 1) C: low density lipoprotein receptor (rattus norvegicus) (aka low density lipoprotein receptor) D: low density lipoprotein receptor (homo sapiens) (aka low density lipoprotein receptor) E: apolipoprotein b receptor (homo sapiens) (aka apolipoprotein b receptor) F: None of the above.
D
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept corresponding to 'low density lipoprotein (ldl) receptor'. Answer using one of the provided options.
<Options>: A: oxidized low density lipoprotein receptor 1 (homo sapiens) (aka oxidized low density lipoprotein receptor 1) B: very low density lipoprotein receptor (homo sapiens) (aka very low density lipoprotein receptor) C: lrp1 (homo sapiens) (ldl receptor related protein 1 (homo sapiens)) (aka ldl receptor related protein 1) D: low density lipoprotein receptor (sus scrofa) (aka low density lipoprotein receptor) E: apolipoprotein b receptor (homo sapiens) (aka apolipoprotein b receptor) F: None of the above.
F
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept corresponding to 'gp330'. Answer using one of the provided options.
<Options>: A: gp330 (xenopus laevis) (aka ldl receptor related protein 2 l homeolog) B: gp330 (mus musculus) (aka low density lipoprotein receptor-related protein 2) C: gp330 (homo sapiens) (aka ldl receptor related protein 2) D: gp330 (xenopus tropicalis) (aka ldl receptor related protein 2) E: gp340 (homo sapiens) (aka deleted in malignant brain tumors 1) F: None of the above.
C
<Instruct>: Given the context 'The deduced amino acid sequence of this protein contains regions with homology to the human low density lipoprotein (LDL) receptor, an indication that GP330 and the LDL receptor may be members of the same gene family.', select the correct biomedical concept corresponding to 'ldl receptor'. Answer using one of the provided options.
<Options>: A: very low density lipoprotein receptor (homo sapiens) (aka very low density lipoprotein receptor) B: apolipoprotein b receptor (homo sapiens) (aka apolipoprotein b receptor) C: low density lipoprotein receptor (homo sapiens) (aka low density lipoprotein receptor) D: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor) E: very low density lipoprotein receptor (gallus gallus) (aka very low density lipoprotein receptor) F: None of the above.
C
<Instruct>: Given the context 'Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor.', select the correct biomedical concept corresponding to 'gp330'. Answer using one of the provided options.
<Options>: A: gp340 (xenopus tropicalis) (aka deleted in malignant brain tumors 1) B: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 s homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 s homeolog) C: gp330 (xenopus laevis) (aka ldl receptor related protein 2 l homeolog) D: gp43 (xenopus laevis) (provisional ortholog of zona pellucida glycoprotein 3 s homeolog (xenopus laevis)) (aka provisional ortholog of zona pellucida glycoprotein 3 s homeolog) E: gp330 (homo sapiens) (aka ldl receptor related protein 2) F: None of the above.
E
<Instruct>: Given the context 'Autoantibodies from the kidneys of rats with Heymann nephritis reacted with a nonglycosylated segment of GP330 that contains cysteine-rich 40-amino acid repeats, which are also features of the LDL receptor.', select the correct biomedical concept corresponding to 'ldl receptor'. Answer using one of the provided options.
<Options>: A: ldlr (homo sapiens) (aka low density lipoprotein receptor) B: low density lipoprotein receptor (gallus gallus) (aka low density lipoprotein receptor) C: lrp1 (homo sapiens) (ldl receptor related protein 1 (homo sapiens)) (aka ldl receptor related protein 1) D: low density lipoprotein receptor (sus scrofa) (aka low density lipoprotein receptor) E: oxidized low density lipoprotein receptor 1 (homo sapiens) (aka oxidized low density lipoprotein receptor 1) F: None of the above.
A
<Instruct>: Given the context 'GP330 is also similar in some regions to the mouse epidermal growth factor precursor.', select the correct biomedical concept corresponding to 'gp330'. Answer using one of the provided options.
<Options>: A: gp340 (homo sapiens) (aka deleted in malignant brain tumors 1) B: gp340 (xenopus tropicalis) (aka deleted in malignant brain tumors 1) C: gp330 (homo sapiens) (aka ldl receptor related protein 2) D: gp280 (homo sapiens) (aka cubilin) E: gp340 (xenopus laevis) (deleted in malignant brain tumors 1 s homeolog (xenopus laevis)) (aka deleted in malignant brain tumors 1 s homeolog) F: None of the above.
C
<Instruct>: Given the context 'Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif. ', select the correct biomedical concept corresponding to 'mrna polyadenylate binding protein'. Answer using one of the provided options.
<Options>: A: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein) B: polyadenylate-binding protein 2-binding protein (arabidopsis thaliana) (aka polyadenylate-binding protein 2-binding protein) C: polyadenylate-binding protein 1 (arabidopsis thaliana) (aka polyadenylate-binding protein 1) D: pabpn1 (homo sapiens) (aka poly(a) binding protein nuclear 1) E: pabp1 (homo sapiens) (poly(a) binding protein cytoplasmic 1 (homo sapiens)) (aka poly(a) binding protein cytoplasmic 1) F: None of the above.
E
<Instruct>: Given the context 'We have isolated a full length cDNA (cDNA) coding for the human poly(A) binding protein.', select the correct biomedical concept corresponding to 'poly(a) binding protein'. Answer using one of the provided options.
<Options>: A: poly(a) binding protein nuclear 1 (homo sapiens) (aka poly(a) binding protein nuclear 1) B: pabp (xenopus tropicalis) (poly(a) binding protein, cytoplasmic 1 (xenopus tropicalis)) (aka poly(a) binding protein, cytoplasmic 1) C: poly(a)-binding protein (arabidopsis thaliana) (aka poly(a)-binding protein 5) D: poly(a) binding protein (drosophila melanogaster) (aka poly(a) binding protein) E: pabp (homo sapiens) (aka poly(a) binding protein cytoplasmic 1) F: None of the above.
E
<Instruct>: Given the context 'The cDNA derived 73 kd basic translation product has the same Mr, isoelectric point and peptidic map as the poly(A) binding protein.', select the correct biomedical concept corresponding to 'poly(a) binding protein'. Answer using one of the provided options.
<Options>: A: poly(a)-binding protein (arabidopsis thaliana) (aka poly(a)-binding protein 5) B: poly(a) binding protein cytoplasmic 1 (homo sapiens) (aka poly(a) binding protein cytoplasmic 1) C: poly(a) binding protein nuclear 1 (homo sapiens) (aka poly(a) binding protein nuclear 1) D: poly(a) binding protein 1 (arabidopsis thaliana) (aka poly(a) binding protein 1) E: polyadenylate-binding protein 1 (arabidopsis thaliana) (aka polyadenylate-binding protein 1) F: None of the above.
B
<Instruct>: Given the context 'The N terminal part, highly homologous to the yeast poly(A) binding protein, is sufficient for poly(A) binding activity.', select the correct biomedical concept corresponding to 'poly(a) binding protein'. Answer using one of the provided options.
<Options>: A: poly(a) binding protein nuclear 1 (homo sapiens) (aka poly(a) binding protein nuclear 1) B: pabp (homo sapiens) (aka poly(a) binding protein cytoplasmic 1) C: poly(a) binding protein 1 (arabidopsis thaliana) (aka poly(a) binding protein 1) D: poly(a) binding protein, cytoplasmic 1 (xenopus tropicalis) (aka poly(a) binding protein, cytoplasmic 1) E: poly(a)-binding protein (arabidopsis thaliana) (aka poly(a)-binding protein 5) F: None of the above.
B