instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'MDS1 is located at 3q26 170-400 kb upstream (telomeric) of EVI1 in the chromosomal region in which some of the breakpoints 5' of EVI1 have been mapped.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
B: evi (homo sapiens) (aka wnt ligand secretion mediator)
C: evi3 (homo sapiens) (aka zinc finger protein 521)
D: evin1 (homo sapiens) (aka transmembrane channel like 6)
E: evi-1 (homo sapiens) (aka runx family transcription factor 1)
F: None of the above. | A |
<Instruct>: Given the context 'MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1 We have analyzed the relationship between MDS1 and EVI1 to determine whether they are two separate genes.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: evi3 (homo sapiens) (aka zinc finger protein 521)
D: evin1 (homo sapiens) (aka transmembrane channel like 6)
E: evi (homo sapiens) (aka wnt ligand secretion mediator)
F: None of the above. | A |
<Instruct>: Given the context 'MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1 We have analyzed the relationship between MDS1 and EVI1 to determine whether they are two separate genes.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
C: ev1 (homo sapiens) (aka transmembrane channel like 6)
D: eve-1 (homo sapiens) (aka sh3 domain containing 19)
E: evi-1 (homo sapiens) (aka runx family transcription factor 1)
F: None of the above. | F |
<Instruct>: Given the context 'MDS1 has been identified as a single gene as well as a previously unreported exon(s) of EVI1 We have analyzed the relationship between MDS1 and EVI1 to determine whether they are two separate genes.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: evi-1 (homo sapiens) (aka runx family transcription factor 1)
B: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
C: eve-1 (homo sapiens) (aka sh3 domain containing 19)
D: evi (homo sapiens) (aka wnt ligand secretion mediator)
E: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
F: None of the above. | B |
<Instruct>: Given the context 'In this report, we present evidence indicating that MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: ev1 (homo sapiens) (aka transmembrane channel like 6)
B: mds1-evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
C: evi (homo sapiens) (aka wnt ligand secretion mediator)
D: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
E: evi3 (homo sapiens) (aka zinc finger protein 521)
F: None of the above. | B |
<Instruct>: Given the context 'In this report, we present evidence indicating that MDS1 exists in normal tissues both as a unique transcript and as a normal fusion transcript with EVI1, with an additional 188 codons at the 5' end of the previously reported EVI1 open reading frame.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
C: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
D: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
E: evi (homo sapiens) (aka wnt ligand secretion mediator)
F: None of the above. | C |
<Instruct>: Given the context 'This additional region has about 40% homology at the amino acid level with the PR domain of the retinoblastoma-interacting zinc-finger protein RIZ.', select the correct biomedical concept corresponding to 'retinoblastoma-interacting zinc-finger protein riz'. Answer using one of the provided options. | <Options>: A: riz2 (homo sapiens) (aka pr/set domain 2)
B: cdkn1a interacting zinc finger protein 1 (homo sapiens) (aka cdkn1a interacting zinc finger protein 1)
C: riaz (homo sapiens) (aka poz/btb and at hook containing zinc finger 1)
D: irz (homo sapiens) (aka arf gtpase activating protein 2)
E: riz (xenopus tropicalis) (aka pr domain containing 2, with znf domain)
F: None of the above. | A |
<Instruct>: Given the context 'These results are important in view of the fact that EVI1 and MDS1 are involved in leukemia associated with chromosomal translocation breakpoints in the region between these genes.', select the correct biomedical concept corresponding to 'evi1'. Answer using one of the provided options. | <Options>: A: evi3 (homo sapiens) (aka zinc finger protein 521)
B: eve-1 (homo sapiens) (aka sh3 domain containing 19)
C: evi-1 (xenopus tropicalis) (mds1 and evi1 complex locus (xenopus tropicalis)) (aka mds1 and evi1 complex locus)
D: evi1 (homo sapiens) (aka mds1 and evi1 complex locus)
E: evi5 (homo sapiens) (aka ecotropic viral integration site 5)
F: None of the above. | D |
<Instruct>: Given the context 'MDC9, a widely expressed cellular disintegrin containing cytoplasmic SH3 ligand domains.
', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
D: adam metallopeptidase domain 9 (homo sapiens) (aka adam metallopeptidase domain 9)
E: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
F: None of the above. | D |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mda-9 (homo sapiens) (aka syndecan binding protein)
D: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
E: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
F: None of the above. | E |
<Instruct>: Given the context 'We have cloned and sequenced the mouse and human homologue of a widely expressed cellular disintegrin, which we have termed MDC9 (for metalloprotease/disintegrin/cysteine-rich protein 9).', select the correct biomedical concept corresponding to 'metalloprotease/disintegrin/cysteine-rich protein 9'. Answer using one of the provided options. | <Options>: A: disintegrin and metalloproteinase domain-containing protein 9 (xenopus tropicalis) (aka disintegrin and metalloproteinase domain-containing protein 9)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
E: disintegrin and metalloproteinase domain-containing protein 9-like (gallus gallus) (aka disintegrin and metalloproteinase domain-containing protein 9-like)
F: None of the above. | C |
<Instruct>: Given the context 'MDC9 contains several distinct protein domains: a signal sequence is followed by a prodomain and a domain with sequence similarity to snake venom metalloproteases, a disintegrin domain, a cysteine-rich region, an EGF repeat, a membrane anchor, and a cytoplasmic tail.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
B: mda-9 (homo sapiens) (aka syndecan binding protein)
C: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
D: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
E: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
F: None of the above. | A |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
B: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
D: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
E: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
F: None of the above. | B |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
D: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
E: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
F: None of the above. | F |
<Instruct>: Given the context 'The cytoplasmic tail of MDC9 has two proline-rich sequences which can bind the SH3 domain of Src, and may therefore function as SH3 ligand domains.', select the correct biomedical concept corresponding to 'src'. Answer using one of the provided options. | <Options>: A: c-src2 (homo sapiens) (aka fgr proto-oncogene, src family tyrosine kinase)
B: src (homo sapiens) (aka src proto-oncogene, non-receptor tyrosine kinase)
C: src3 (homo sapiens) (aka nuclear receptor coactivator 3)
D: src (sus scrofa) (aka src proto-oncogene, non-receptor tyrosine kinase)
E: src1 (homo sapiens) (aka nuclear receptor coactivator 1)
F: None of the above. | B |
<Instruct>: Given the context 'Western blot analysis shows that MDC9 is an approximately 84-kD glycoprotein in all mouse tissues examined, and in NIH 3T3 fibroblast and C2C12 myoblast mouse cell lines.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
E: mda-9 (homo sapiens) (aka syndecan binding protein)
F: None of the above. | C |
<Instruct>: Given the context 'MDC9 can be both cell surface biotinylated and 125I-labeled in NIH 3T3 mouse fibroblasts, indicating that the protein is present on the plasma membrane.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
E: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
B: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
C: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
E: mda-9 (homo sapiens) (aka syndecan binding protein)
F: None of the above. | C |
<Instruct>: Given the context 'Expression of MDC9 in COS-7 cells yields an 84-kD protein, and immunofluorescence analysis of COS-7 cells expressing MDC9 shows a staining pattern that is consistent with a plasma membrane localization.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
C: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
D: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
E: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
F: None of the above. | B |
<Instruct>: Given the context 'The apparent molecular mass of 84 kD suggests that MDC9 contains a membrane-anchored metalloprotease and disintegrin domain.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mda-9 (homo sapiens) (aka syndecan binding protein)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: mdc-l (homo sapiens) (aka adam metallopeptidase domain 28)
E: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
F: None of the above. | C |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
B: mdc-3 (homo sapiens) (aka adam metallopeptidase domain 23)
C: mdc9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
E: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
F: None of the above. | C |
<Instruct>: Given the context 'We propose that MDC9 might function as a membrane-anchored integrin ligand or metalloprotease, or that MDC9 may combine both activities in one protein.', select the correct biomedical concept corresponding to 'mdc9'. Answer using one of the provided options. | <Options>: A: mdc9 (mus musculus) (aka adam metallopeptidase domain 9)
B: adam metallopeptidase with thrombospondin type 1 motif 9 (homo sapiens) (aka adam metallopeptidase with thrombospondin type 1 motif 9)
C: adam9 (homo sapiens) (aka adam metallopeptidase domain 9)
D: disintegrin and metalloproteinase domain-containing protein 10 homolog (caenorhabditis elegans) (aka disintegrin and metalloproteinase domain-containing protein 10 homolog)
E: mdc15 (homo sapiens) (aka adam metallopeptidase domain 15)
F: None of the above. | C |
<Instruct>: Given the context 'A GLRA1 null mutation in recessive hyperekplexia challenges the functional role of glycine receptors.
', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
B: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glra1 (homo sapiens) (aka glycine receptor alpha 1)
D: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
E: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
F: None of the above. | C |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glycine receptor (glyr) alpha 1'. Answer using one of the provided options. | <Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
C: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
D: cg-alpha-1 (glycine max) (aka beta-conglycinin, alpha chain-like)
E: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
F: None of the above. | E |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glycine receptor (glyr) alpha 1'. Answer using one of the provided options. | <Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
D: cg-alpha-1 (glycine max) (aka beta-conglycinin, alpha chain-like)
E: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
F: None of the above. | F |
<Instruct>: Given the context 'Dominant missense mutations in the human glycine receptor (GlyR) alpha 1 subunit gene (GLRA1) give rise to hereditary hyperekplexia.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
B: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
C: glra1 (homo sapiens) (aka glycine receptor alpha 1)
D: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
E: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
F: None of the above. | C |
<Instruct>: Given the context 'In a recessive case of hyperekplexia, we found a deletion of exons 1-6 of the GLRA1 gene.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (mus musculus) (aka glycine receptor, alpha 1 subunit)
B: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glra1 (homo sapiens) (aka glycine receptor alpha 1)
E: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
F: None of the above. | D |
<Instruct>: Given the context 'Born to consanguineous parents, the affected child is homozygous for this GLRA1(null) allele consistent with a complete loss of gene function.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
C: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
D: glra1 (homo sapiens) (aka glycine receptor alpha 1)
E: glra1 (rattus norvegicus) (aka glycine receptor, alpha 1)
F: None of the above. | D |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'glra1'. Answer using one of the provided options. | <Options>: A: glutamate receptor 1.1-like (glycine max) (aka glutamate receptor 1.1-like)
B: glra4 (homo sapiens) (aka glycine receptor alpha 4 (pseudogene))
C: glra1.l (xenopus laevis) (aka glycine receptor alpha 1 l homeolog)
D: glra1 (xenopus tropicalis) (aka glycine receptor alpha 1)
E: glra1 (homo sapiens) (aka glycine receptor alpha 1)
F: None of the above. | E |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'spd'. Answer using one of the provided options. | <Options>: A: spdt (homo sapiens) (aka spondyloepiphyseal dysplasia tarda, autosomal dominant)
B: spd (homo sapiens) (aka homeobox d13)
C: spdl1 (homo sapiens) (aka spindle apparatus coiled-coil protein 1)
D: spd3 (homo sapiens) (aka synpolydactyly 3)
E: spdyc (homo sapiens) (aka speedy/ringo cell cycle regulator family member c)
F: None of the above. | F |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'ot'. Answer using one of the provided options. | <Options>: A: otx1 (oryctolagus cuniculus) (aka orthodenticle homeobox 1)
B: otr (homo sapiens) (aka oxytocin receptor)
C: otop3 (oryctolagus cuniculus) (aka otopetrin 3)
D: otop1 (oryctolagus cuniculus) (aka otopetrin 1)
E: otr (drosophila melanogaster) (aka octopamine-tyramine receptor)
F: None of the above. | F |
<Instruct>: Given the context 'This case demonstrates that, in contrast to the lethal effect of a null allele in the recessive mouse mutant oscillator (Glra1 spd-ot), the loss of the GlyR alpha 1 subunit is effectively compensated in man.', select the correct biomedical concept corresponding to 'glyr alpha 1'. Answer using one of the provided options. | <Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
F: None of the above. | E |
<Instruct>: Given the context 'Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family.
', select the correct biomedical concept corresponding to 'apo-2 ligand'. Answer using one of the provided options. | <Options>: A: cd40 ligand (homo sapiens) (aka cd40 ligand)
B: tall-2 (homo sapiens) (aka tnf superfamily member 13)
C: apo-2l (homo sapiens) (aka tnf superfamily member 10)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: apo-l (homo sapiens) (aka apolipoprotein l1)
F: None of the above. | C |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2 ligand'. Answer using one of the provided options. | <Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo2l (homo sapiens) (aka tnf superfamily member 10)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
E: fas ligand (homo sapiens) (aka fas ligand)
F: None of the above. | B |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: cd95l (homo sapiens) (aka fas ligand)
D: apo-2l (homo sapiens) (aka tnf superfamily member 10)
E: tall2 (homo sapiens) (aka tnf superfamily member 13)
F: None of the above. | D |
<Instruct>: Given the context 'We have isolated a new member of this family, designated Apo-2 ligand (Apo-2L), via an expressed sequence tag.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: cd95-l (homo sapiens) (aka fas ligand)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: tall-2 (homo sapiens) (aka tnf superfamily member 13)
F: None of the above. | F |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apo-2l (homo sapiens) (aka tnf superfamily member 10)
C: cd95l (homo sapiens) (aka fas ligand)
D: apo3l (homo sapiens) (aka tnf superfamily member 12)
E: tall2 (homo sapiens) (aka tnf superfamily member 13)
F: None of the above. | B |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas-as (homo sapiens) (aka fas antisense rna 1)
B: fasn (homo sapiens) (aka fatty acid synthase)
C: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
D: fasps (homo sapiens) (aka period circadian regulator 2)
E: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
F: None of the above. | C |
<Instruct>: Given the context 'Apo-2L is a 281-amino acid protein, related most closely to Fas/Apo-1 ligand.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: apo-l (homo sapiens) (aka apolipoprotein l1)
B: apo-1 (homo sapiens) (aka fas cell surface death receptor)
C: fas ligand (homo sapiens) (aka fas ligand)
D: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
E: cd40 ligand (homo sapiens) (aka cd40 ligand)
F: None of the above. | B |
<Instruct>: Given the context 'Transfected Apo-2L is expressed at the cell surface with its C terminus exposed, indicating a type II transmembrane protein topology.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: cd95l (homo sapiens) (aka fas ligand)
B: apo2l (homo sapiens) (aka tnf superfamily member 10)
C: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
D: apol2 (homo sapiens) (aka apolipoprotein l2)
E: apo3l (homo sapiens) (aka tnf superfamily member 12)
F: None of the above. | B |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
C: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
D: fasas (homo sapiens) (aka fas antisense rna 1)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F: None of the above. | C |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: tall-1 (homo sapiens) (aka tnf superfamily member 13b)
B: cd40 ligand (homo sapiens) (aka cd40 ligand)
C: apo-l (homo sapiens) (aka apolipoprotein l1)
D: fas ligand (homo sapiens) (aka fas ligand)
E: apo-1 (homo sapiens) (aka fas cell surface death receptor)
F: None of the above. | E |
<Instruct>: Given the context 'Like Fas/Apo-1 ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) exhibits a homotrimeric subunit structure.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: cd95-l (homo sapiens) (aka fas ligand)
C: apo3l (homo sapiens) (aka tnf superfamily member 12)
D: apo2l (homo sapiens) (aka tnf superfamily member 10)
E: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
F: None of the above. | D |
<Instruct>: Given the context 'Soluble Apo-2L induces extensive apoptosis in lymphoid as well as non-lymphoid tumor cell lines.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apol2 (homo sapiens) (aka apolipoprotein l2)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: tall-2 (homo sapiens) (aka tnf superfamily member 13)
E: apo3l (homo sapiens) (aka tnf superfamily member 12)
F: None of the above. | C |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: tall2 (homo sapiens) (aka tnf superfamily member 13)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: apo2l (homo sapiens) (aka tnf superfamily member 10)
D: apol2 (homo sapiens) (aka apolipoprotein l2)
E: cd95-l (homo sapiens) (aka fas ligand)
F: None of the above. | C |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
C: fas-as (homo sapiens) (aka fas antisense rna 1)
D: fasps (homo sapiens) (aka period circadian regulator 2)
E: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
F: None of the above. | B |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fasas (homo sapiens) (aka fas antisense rna 1)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F: None of the above. | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-1'. Answer using one of the provided options. | <Options>: A: cd951 (homo sapiens) (aka fas cell surface death receptor)
B: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
C: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
D: trail (homo sapiens) (aka tnf superfamily member 10)
E: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
F: None of the above. | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
B: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
C: fas-as (homo sapiens) (aka fas antisense rna 1)
D: fasps (homo sapiens) (aka period circadian regulator 2)
E: fas (gallus gallus) (aka fas cell surface death receptor)
F: None of the above. | A |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-1'. Answer using one of the provided options. | <Options>: A: trail (homo sapiens) (aka tnf superfamily member 10)
B: apol-i (homo sapiens) (aka apolipoprotein l1)
C: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
D: apo-1 (homo sapiens) (aka fas cell surface death receptor)
E: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
F: None of the above. | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas (gallus gallus) (aka fas cell surface death receptor)
B: fas (homo sapiens) (fatty acid synthase (homo sapiens)) (aka fatty acid synthase)
C: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
D: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F: None of the above. | D |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-1'. Answer using one of the provided options. | <Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
C: trail (homo sapiens) (aka tnf superfamily member 10)
D: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
E: apoop1 (homo sapiens) (aka apolipoprotein o pseudogene 1)
F: None of the above. | F |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: cd95l (homo sapiens) (aka fas ligand)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: apo-2l (homo sapiens) (aka tnf superfamily member 10)
D: apol2 (homo sapiens) (aka apolipoprotein l2)
E: tall2 (homo sapiens) (aka tnf superfamily member 13)
F: None of the above. | C |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apol2 (homo sapiens) (aka apolipoprotein l2)
B: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
C: cd95-l (homo sapiens) (aka fas ligand)
D: apo2l (homo sapiens) (aka tnf superfamily member 10)
E: apo3l (homo sapiens) (aka tnf superfamily member 12)
F: None of the above. | D |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fas cell surface death receptor (homo sapiens) (aka fas cell surface death receptor)
B: fasps (homo sapiens) (aka period circadian regulator 2)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fast (homo sapiens) (fas activated serine/threonine kinase (homo sapiens)) (aka fas activated serine/threonine kinase)
E: fasas (homo sapiens) (aka fas antisense rna 1)
F: None of the above. | A |
<Instruct>: Given the context 'The effect of Apo-2L is not inhibited by soluble Fas/Apo-1 and TNF receptors; moreover, expression of human Fas/Apo-1 in mouse fibroblasts, which confers sensitivity to induction of apoptosis by agonistic anti-Fas/Apo-1 antibody, does not confer sensitivity to Apo-2L. Hence, Apo-2L acts via a receptor which is distinct from Fas/Apo-1 and TNF receptors.', select the correct biomedical concept corresponding to 'apo-1'. Answer using one of the provided options. | <Options>: A: apof (homo sapiens) (aka apolipoprotein f)
B: apo-1 (xenopus tropicalis) (aka fas cell surface death receptor)
C: apo-1 (homo sapiens) (aka fas cell surface death receptor)
D: apo-3 (homo sapiens) (aka tnf receptor superfamily member 25)
E: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
F: None of the above. | F |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasas (homo sapiens) (aka fas antisense rna 1)
B: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
C: fas (homo sapiens) (fas cell surface death receptor (homo sapiens)) (aka fas cell surface death receptor)
D: fas (gallus gallus) (aka fas cell surface death receptor)
E: fasn (homo sapiens) (aka fatty acid synthase)
F: None of the above. | C |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'fas'. Answer using one of the provided options. | <Options>: A: fasn (homo sapiens) (aka fatty acid synthase)
B: fas activated serine/threonine kinase (homo sapiens) (aka fas activated serine/threonine kinase)
C: fas (gallus gallus) (aka fas cell surface death receptor)
D: fasas (homo sapiens) (aka fas antisense rna 1)
E: fasps (homo sapiens) (aka period circadian regulator 2)
F: None of the above. | F |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'apo-1 ligand'. Answer using one of the provided options. | <Options>: A: apo-1 (homo sapiens) (aka fas cell surface death receptor)
B: fas ligand (homo sapiens) (aka fas ligand)
C: apo-2l (homo sapiens) (aka tnf superfamily member 10)
D: apo1 (homo sapiens) (aka apolipoprotein b mrna editing enzyme catalytic subunit 1)
E: cd40 ligand (homo sapiens) (aka cd40 ligand)
F: None of the above. | A |
<Instruct>: Given the context 'These results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.', select the correct biomedical concept corresponding to 'apo-2l'. Answer using one of the provided options. | <Options>: A: apo2 (homo sapiens) (aka tnf receptor superfamily member 10a)
B: apo3l (homo sapiens) (aka tnf superfamily member 12)
C: apol2 (homo sapiens) (aka apolipoprotein l2)
D: trail (homo sapiens) (aka tnf superfamily member 10)
E: tall-2 (homo sapiens) (aka tnf superfamily member 13)
F: None of the above. | D |
<Instruct>: Given the context 'Polypeptide N-acetylgalactosaminyltransferase, GalNAc-t3.
', select the correct biomedical concept corresponding to 'polypeptide n-acetylgalactosaminyltransferase, galnac-t3'. Answer using one of the provided options. | <Options>: A: b4galnt3 (homo sapiens) (aka beta-1,4-n-acetyl-galactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (caenorhabditis elegans) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
D: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
E: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
F: None of the above. | C |
<Instruct>: Given the context 'Here we report the cDNA cloning and expression of a novel GalNAc-transferase termed GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
C: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
D: galnac-t3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
E: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3))
F: None of the above. | D |
<Instruct>: Given the context 'The overall amino acid sequence similarity with GalNAc-T1 and -T2 is approximately 45%; 12 cysteine residues that are shared between GalNAc-T1 and -T2 are also found in GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
C: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3))
D: galnt3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
E: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
F: None of the above. | A |
<Instruct>: Given the context 'GalNAc-T3 was expressed as a soluble protein without the hydrophobic transmembrane domain in insect cells using a Baculo-virus vector, and the expressed GalNAc-transferase activity showed substrate specificity different from that previously reported for GalNAc-T1 and -T2.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: galnt3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3))
C: polypeptide n-acetylgalactosaminyltransferase 3 (bos taurus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
D: polypeptide n-acetylgalactosaminyltransferase 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 3)
E: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
F: None of the above. | A |
<Instruct>: Given the context 'Northern analysis of human organs revealed a very restricted expression pattern of GalNAc-T3.', select the correct biomedical concept corresponding to 'galnac-t3'. Answer using one of the provided options. | <Options>: A: polypeptide n-acetylgalactosaminyltransferase 3 (drosophila melanogaster) (aka polypeptide n-acetylgalactosaminyltransferase 3)
B: polypeptide n-acetylgalactosaminyltransferase 6, gene 3 (xenopus tropicalis) (aka polypeptide n-acetylgalactosaminyltransferase 6, gene 3)
C: udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3) (danio rerio) (aka udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase 3 (galnac-t3))
D: polypeptide n-acetylgalactosaminyltransferase 3 (gallus gallus) (aka polypeptide n-acetylgalactosaminyltransferase 3)
E: polypeptide n-acetylgalactosaminyltransferase 3 (homo sapiens) (aka polypeptide n-acetylgalactosaminyltransferase 3)
F: None of the above. | E |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining of the 60 S ribosomal subunit to the 40 S initiation complex to form a functional 80 S initiation complex.', select the correct biomedical concept corresponding to 'mammalian translation initiation factor 5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5a (homo sapiens) (aka eukaryotic translation initiation factor 5a)
C: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-5)
D: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
E: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
F: None of the above. | A |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining of the 60 S ribosomal subunit to the 40 S initiation complex to form a functional 80 S initiation complex.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
D: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
E: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
F: None of the above. | A |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining of the 60 S ribosomal subunit to the 40 S initiation complex to form a functional 80 S initiation complex.', select the correct biomedical concept corresponding to 'eukaryotic translation initiation factor 5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5a (homo sapiens) (aka eukaryotic translation initiation factor 5a)
C: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
D: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
E: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
F: None of the above. | D |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining of the 60 S ribosomal subunit to the 40 S initiation complex to form a functional 80 S initiation complex.', select the correct biomedical concept corresponding to 'eukaryotic translation initiation factor 5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 4e-5 (caenorhabditis elegans) (aka eukaryotic translation initiation factor 4e-5)
D: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
E: eukaryotic translation initiation factor 5a (homo sapiens) (aka eukaryotic translation initiation factor 5a)
F: None of the above. | F |
<Instruct>: Given the context 'Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5).
Eukaryotic translation initiation factor 5 (eIF-5) interacts with the 40 S initiation complex (40S.mRNA.MettRNAf.eIF-2.GTP) to promote the hydrolysis of bound GTP with the concomitant joining of the 60 S ribosomal subunit to the 40 S initiation complex to form a functional 80 S initiation complex.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
D: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
E: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
F: None of the above. | D |
<Instruct>: Given the context 'In this paper, the multiple mRNAs that encode mammalian eIF-5 have been characterized.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
D: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
E: eif-5a (homo sapiens) (eukaryotic translation initiation factor 5 (homo sapiens)) (aka eukaryotic translation initiation factor 5)
F: None of the above. | E |
<Instruct>: Given the context 'In rat tissues, three major eIF-5 mRNAs of 3.5, 2.8, and 2.2 kilobases in length are detected.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (drosophila melanogaster) (aka eukaryotic translation initiation factor 5)
D: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
E: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
F: None of the above. | A |
<Instruct>: Given the context 'All major eIF-5 mRNAs are initiated from a single transcription initiation site, contain identical 5'-untranslated and coding regions, but differ from one another only in the length of their 3'-untranslated regions.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
B: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
D: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
E: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
F: None of the above. | A |
<Instruct>: Given the context 'The different lengths of the 3'-untranslated region of eIF-5 mRNAs are generated by the use of alternative polyadenylation signals.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
D: eif5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
E: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
F: None of the above. | D |
<Instruct>: Given the context 'Additionally, we demonstrate tissue-specific variations in eIF-5 mRNA expression as well as preference for polyadenylation sites.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
B: eif5 (drosophila melanogaster) (eukaryotic translation initiation factor 5 (drosophila melanogaster)) (aka eukaryotic translation initiation factor 5)
C: eukaryotic translation initiation factor 5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
D: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
E: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
F: None of the above. | C |
<Instruct>: Given the context 'These results should lead to increased understanding of the regulation of eIF-5 gene expression.', select the correct biomedical concept corresponding to 'eif-5'. Answer using one of the provided options. | <Options>: A: eif1p5 (homo sapiens) (aka eukaryotic translation initiation factor 1 pseudogene 5)
B: translation initiation factor eif5 (saccharomyces cerevisiae s288c) (aka translation initiation factor eif5)
C: eif-5 (homo sapiens) (aka eukaryotic translation initiation factor 5)
D: eukaryotic translation initiation factor 5 (xenopus tropicalis) (aka eukaryotic translation initiation factor 5)
E: eukaryotic translation initiation factor 5 (mus musculus) (aka eukaryotic translation initiation factor 5)
F: None of the above. | C |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: ice-lap6 (xenopus tropicalis) (aka caspase 9)
D: caspase-6 (homo sapiens) (aka caspase 6)
E: casp-7 (homo sapiens) (aka caspase 7)
F: None of the above. | B |
<Instruct>: Given the context 'ICE-LAP6, a novel member of the ICE/Ced-3 gene family, is activated by the cytotoxic T cell protease granzyme B.
Members of the ICE/Ced-3 gene family are likely effector components of the cell death machinery.', select the correct biomedical concept corresponding to 'granzyme b'. Answer using one of the provided options. | <Options>: A: granzyme b-like (rattus norvegicus) (aka granzyme b-like)
B: granzyme h (homo sapiens) (aka granzyme h)
C: granzyme b (bos taurus) (aka granzyme b)
D: granzyme b (homo sapiens) (aka granzyme b)
E: granzyme b (rattus norvegicus) (aka granzyme b)
F: None of the above. | D |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp-8 (homo sapiens) (aka caspase 8)
B: ice-lap3 (homo sapiens) (aka caspase 7)
C: caspase-6 (homo sapiens) (aka caspase 6)
D: ice-lap6 (mus musculus) (aka caspase 9)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | E |
<Instruct>: Given the context 'Here, we characterize a novel member of this family designated ICE-LAP6.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: caspase 6 (homo sapiens) (aka caspase 6)
B: ice-lap3 (homo sapiens) (aka caspase 7)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: ice-lap6 (mus musculus) (aka caspase 9)
E: ice-lap6 (xenopus tropicalis) (aka caspase 9)
F: None of the above. | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp-7 (homo sapiens) (aka caspase 7)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: casp16 (homo sapiens) (aka caspase 16, pseudogene)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (mus musculus) (aka caspase 9)
F: None of the above. | B |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'yama'. Answer using one of the provided options. | <Options>: A: yam-1 (homo sapiens) (aka yy1-associated myogenesis rna 1)
B: chica (homo sapiens) (aka family with sequence similarity 83 member d)
C: cuta divalent cation tolerance homolog (sus scrofa) (aka cuta divalent cation tolerance homolog)
D: drosophila executioner caspase related to apopain/yama (drosophila melanogaster) (aka death executioner caspase related to apopain/yama)
E: yama (rattus norvegicus) (aka caspase 3)
F: None of the above. | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'cpp32'. Answer using one of the provided options. | <Options>: A: spgf32 (homo sapiens) (aka spermatogenesis and oogenesis specific basic helix-loop-helix 1)
B: hcp32 (homo sapiens) (aka cycs pseudogene 32)
C: pp32 (homo sapiens) (aka acidic nuclear phosphoprotein 32 family member a)
D: cpp32b (homo sapiens) (aka caspase 3)
E: esp32 (homo sapiens) (aka colipase like 1)
F: None of the above. | D |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'apopain'. Answer using one of the provided options. | <Options>: A: apoh (homo sapiens) (aka apolipoprotein h)
B: apopain (xenopus laevis) (aka caspase 3, gene 2 l homeolog)
C: apon (rattus norvegicus) (aka apolipoprotein n)
D: aponp (homo sapiens) (aka apolipoprotein n, pseudogene)
E: apol (homo sapiens) (aka apolipoprotein l1)
F: None of the above. | F |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'mch2'. Answer using one of the provided options. | <Options>: A: melanin concentrating hormone receptor 2 (homo sapiens) (aka melanin concentrating hormone receptor 2)
B: hmcn2 (homo sapiens) (aka hemicentin 2)
C: mch2 (mus musculus) (aka caspase 6)
D: mch3 (homo sapiens) (aka caspase 7)
E: None of the above. | E |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'ice-lap3'. Answer using one of the provided options. | <Options>: A: ice-lap3 (xenopus tropicalis) (aka caspase 7)
B: ice-lap3 (homo sapiens) (aka caspase 7)
C: caspase 3 (drosophila melanogaster) (death related ice-like caspase (drosophila melanogaster)) (aka death related ice-like caspase)
D: casp3 (homo sapiens) (aka caspase 3)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | B |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'mch3'. Answer using one of the provided options. | <Options>: A: caspase 3 (homo sapiens) (aka caspase 3)
B: mch5 (homo sapiens) (aka caspase 8)
C: ligand-gated chloride channel homolog 3 (drosophila melanogaster) (aka ligand-gated chloride channel homolog 3)
D: mch3 (mus musculus) (aka caspase 7)
E: mch3 (homo sapiens) (aka caspase 7)
F: None of the above. | E |
<Instruct>: Given the context 'By phylogenetic analysis, ICE-LAP6 is classified into the Ced-3 subfamily which includes Ced-3, Yama/CPP32/apopain, Mch2, and ICE-LAP3/Mch3/CMH-1.', select the correct biomedical concept corresponding to 'cmh-1'. Answer using one of the provided options. | <Options>: A: cmh-1 (homo sapiens) (aka caspase 7)
B: hcam-1 (homo sapiens) (aka phosphodiesterase 1a)
C: mlh-1 (homo sapiens) (aka mutl homolog 1)
D: cmh1 (homo sapiens) (aka myosin heavy chain 7)
E: cmg-1 (homo sapiens) (aka intraflagellar transport 74)
F: None of the above. | A |
<Instruct>: Given the context 'Interestingly, ICE-LAP6 contains an active site QACGG pentapeptide, rather than the QACRG pentapeptide shared by other family members.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (xenopus tropicalis) (aka caspase 9)
B: ice-lap6 (homo sapiens) (aka caspase 9)
C: caspase-6 (homo sapiens) (aka caspase 6)
D: casp-8 (homo sapiens) (aka caspase 8)
E: casp-7 (homo sapiens) (aka caspase 7)
F: None of the above. | B |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp16 (homo sapiens) (aka caspase 16, pseudogene)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: casp-8 (homo sapiens) (aka caspase 8)
E: casp-7 (homo sapiens) (aka caspase 7)
F: None of the above. | C |
<Instruct>: Given the context 'Overexpression of ICE-LAP6 induces apoptosis in MCF7 breast carcinoma cells.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: ice-lap6 (mus musculus) (aka caspase 9)
B: ice-lap6 (xenopus tropicalis) (aka caspase 9)
C: casp-8 (homo sapiens) (aka caspase 8)
D: casp16 (homo sapiens) (aka caspase 16, pseudogene)
E: casp-7 (homo sapiens) (aka caspase 7)
F: None of the above. | F |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp6 (homo sapiens) (aka caspase 6)
B: ice-lap6 (mus musculus) (aka caspase 9)
C: ice-lap6 (homo sapiens) (aka caspase 9)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: casp16 (homo sapiens) (aka caspase 16, pseudogene)
F: None of the above. | C |
<Instruct>: Given the context 'More importantly, ICE-LAP6 is proteolytically processed into an active cysteine protease by granzyme B, an important component of cytotoxic T cell-mediated apoptosis.', select the correct biomedical concept corresponding to 'granzyme b'. Answer using one of the provided options. | <Options>: A: granzyme b (granzyme 2, cytotoxic t-lymphocyte-associated serine esterase 1) (bos taurus) (aka granzyme b (granzyme 2, cytotoxic t-lymphocyte-associated serine esterase 1))
B: cathepsin b (homo sapiens) (aka cathepsin b)
C: granzyme b (mus musculus) (aka granzyme b)
D: granzyme h (homo sapiens) (aka granzyme h)
E: granzyme b (homo sapiens) (aka granzyme b)
F: None of the above. | E |
<Instruct>: Given the context 'Once activated, ICE-LAP6 is able to cleave the death substrate poly(ADP-ribose) polymerase into signature apoptotic fragments.', select the correct biomedical concept corresponding to 'ice-lap6'. Answer using one of the provided options. | <Options>: A: casp6 (homo sapiens) (aka caspase 6)
B: casp16 (homo sapiens) (aka caspase 16, pseudogene)
C: ice-lap6 (mus musculus) (aka caspase 9)
D: ice-lap6 (xenopus tropicalis) (aka caspase 9)
E: ice-lap6 (homo sapiens) (aka caspase 9)
F: None of the above. | E |
<Instruct>: Given the context 'Molecular cloning, expression and function of the murine CB2 peripheral cannabinoid receptor.
', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options. | <Options>: A: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
B: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
C: cmkbr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
D: corticotropin releasing hormone receptor 2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
E: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
F: None of the above. | F |
<Instruct>: Given the context 'We have cloned the peripheral cannabinoid receptor, mCB2, from a mouse splenocyte cDNA library.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
C: b cell maturation defect 2 (mus musculus) (aka b cell maturation defect 2)
D: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
E: mcop2 (homo sapiens) (aka visual system homeobox 2)
F: None of the above. | F |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corresponding to 'cb2'. Answer using one of the provided options. | <Options>: A: ckr2 (homo sapiens) (aka c-c motif chemokine receptor 2)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: neuropeptides b and w receptor 2 (homo sapiens) (aka neuropeptides b and w receptor 2)
D: gprchr2 (homo sapiens) (aka g protein-coupled receptor 75)
E: cannabinoid receptor 2 (homo sapiens) (aka cannabinoid receptor 2)
F: None of the above. | E |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corresponding to 'hcb2'. Answer using one of the provided options. | <Options>: A: csnb2b (homo sapiens) (aka calcium binding protein 4)
B: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
C: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
D: cpeb2 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 2)
E: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
F: None of the above. | F |
<Instruct>: Given the context 'The 3.7 kb sequence contains an open reading frame encoding a protein of 347 residues sharing 82% overall identity with the only other known peripheral receptor, human CB2 (hCB2) and shorter than hCB2 by 13 amino acids at the carboxyl terminus.', select the correct biomedical concept corresponding to 'hcb2'. Answer using one of the provided options. | <Options>: A: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
B: cpeb2 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 2)
C: cbc2 (homo sapiens) (aka nuclear cap binding protein subunit 2)
D: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
E: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
F: None of the above. | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide and almost no affinity for the central receptor- (CB1) specific antagonist SR 141716A.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: mbc2 (mus musculus) (aka extended synaptotagmin-like protein 1)
C: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
D: mc2 (homo sapiens) (aka melanocortin 5 receptor)
E: bmch2 (mus musculus) (aka bone mechanical trait 2)
F: None of the above. | F |
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