instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'We report here the crystal structures of full-length human CaN at 2.1 A resolution and of the complex of human CaN with FKBP12-FK506 at 3.5 A resolution.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp22 (homo sapiens) (aka fkbp prolyl isomerase 14)
B: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
E: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
F: None of the above. | B |
<Instruct>: Given the context 'In the FKBP12-FK506-CaN complex, the auto-inhibitory element is displaced from the active site.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp-12 (oryctolagus cuniculus) (aka fkbp prolyl isomerase 1a)
B: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
C: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
D: fkbp12.6 (homo sapiens) (aka fkbp prolyl isomerase 1b)
E: fkbp6 (homo sapiens) (aka fkbp prolyl isomerase family member 6 (inactive))
F: None of the above. | B |
<Instruct>: Given the context 'The site of binding of FKBP12-FK506 appears to be shared by other non-competitive inhibitors of calcineurin, including a natural anchoring protein.', select the correct biomedical concept corresponding to 'fkbp12'. Answer using one of the provided options. | <Options>: A: fkbp11 (homo sapiens) (aka fkbp prolyl isomerase 11)
B: fkbpl (homo sapiens) (aka fkbp prolyl isomerase like)
C: fkbp13 (homo sapiens) (aka fkbp prolyl isomerase 2)
D: fkbp-12 (xenopus tropicalis) (aka fkbp prolyl isomerase 1a)
E: fkbp12 (homo sapiens) (fkbp prolyl isomerase 1a (homo sapiens)) (aka fkbp prolyl isomerase 1a)
F: None of the above. | E |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
F: None of the above. | D |
<Instruct>: Given the context 'HCC-1, a novel chemokine from human plasma.
', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: None of the above. | F |
<Instruct>: Given the context 'A novel CC chemokine, HCC-1, was isolated from the hemofiltrate of patients with chronic renal failure.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
E: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
F: None of the above. | E |
<Instruct>: Given the context 'HCC-1 has a relative molecular mass of 8,673 and consists of 74 amino acids including four cysteines linked to disulfide bonds.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
D: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
E: hcca1 (homo sapiens) (aka yy1 associated protein 1)
F: None of the above. | A |
<Instruct>: Given the context 'HCC-1 cDNA was cloned from human bone marrow and shown to code for the mature protein plus a putative 19-residue leader sequence.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
D: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
E: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
F: None of the above. | E |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcca1 (homo sapiens) (aka yy1 associated protein 1)
B: hccs-1 (homo sapiens) (aka suppressor of tumorigenicity 20)
C: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
F: None of the above. | D |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'macrophage inflammatory protein (mip)-1 alpha'. Answer using one of the provided options. | <Options>: A: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
B: c-x-c motif chemokine ligand 1 (homo sapiens) (aka c-x-c motif chemokine ligand 1)
C: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
D: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
E: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
F: None of the above. | D |
<Instruct>: Given the context 'Mature HCC-1 has sequence identity of 46% with macrophage inflammatory protein (MIP)-1 alpha and MIP-1 beta, and 29-37% with the other human CC chemokines.', select the correct biomedical concept corresponding to 'mip-1 beta'. Answer using one of the provided options. | <Options>: A: mip-1-beta (homo sapiens) (c-c motif chemokine ligand 4 like 1 (homo sapiens)) (aka c-c motif chemokine ligand 4 like 1)
B: mip-3b (homo sapiens) (aka c-c motif chemokine ligand 19)
C: mip-2b (homo sapiens) (aka c-x-c motif chemokine ligand 3)
D: mip-1-beta (xenopus tropicalis) (aka c-c motif chemokine ligand 4)
E: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
F: None of the above. | E |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: mip1a (homo sapiens) (aka c-c motif chemokine ligand 3)
B: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
C: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
D: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
E: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
F: None of the above. | A |
<Instruct>: Given the context 'Unlike MIP-1 alpha and the other CC chemokines, HCC-1 is expressed constitutively in several normal tissues (spleen, liver, skeletal and heart muscle, gut, and bone marrow), and is present at high concentrations (1-80 nM) in plasma.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
B: hcca1 (homo sapiens) (aka yy1 associated protein 1)
C: hcc3 (homo sapiens) (aka fun14 domain containing 2)
D: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
E: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
F: None of the above. | A |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc5 (homo sapiens) (aka minichromosome maintenance complex component 3)
B: hcc-1 (homo sapiens) (aka c-c motif chemokine ligand 14)
C: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
D: hcca1 (homo sapiens) (aka yy1 associated protein 1)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: None of the above. | B |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
B: mip-3-alpha (homo sapiens) (aka c-c motif chemokine ligand 20)
C: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
D: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
E: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
F: None of the above. | C |
<Instruct>: Given the context 'HCC-1 has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: c-x3-c motif chemokine ligand 1 (homo sapiens) (aka c-x3-c motif chemokine ligand 1)
B: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
C: c-c motif chemokine ligand 1 (homo sapiens) (aka c-c motif chemokine ligand 1)
D: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
E: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
F: None of the above. | F |
<Instruct>: Given the context 'In addition, HCC-1 enhanced the proliferation of CD34+ myeloid progenitor cells.', select the correct biomedical concept corresponding to 'hcc-1'. Answer using one of the provided options. | <Options>: A: hcc2 (homo sapiens) (aka thioredoxin domain containing 5)
B: hccs1 (homo sapiens) (aka vps53 subunit of garp complex)
C: hcca1 (homo sapiens) (aka yy1 associated protein 1)
D: hcc-1/hcc-3 (homo sapiens) (aka c-c motif chemokine ligand 14)
E: hccr1 (homo sapiens) (aka letm1 domain containing 1)
F: None of the above. | D |
<Instruct>: Given the context 'It was as effective as MIP-1 alpha, but about 100-fold less potent.', select the correct biomedical concept corresponding to 'mip-1 alpha'. Answer using one of the provided options. | <Options>: A: mip-3a (homo sapiens) (aka c-c motif chemokine ligand 20)
B: mip-4a (homo sapiens) (aka c-c motif chemokine ligand 26)
C: mip1ap (homo sapiens) (aka c-c motif chemokine ligand 3 like 1)
D: mip-1-alpha (homo sapiens) (aka c-c motif chemokine ligand 3)
E: mip1b (homo sapiens) (aka c-c motif chemokine ligand 4)
F: None of the above. | D |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: None of the above. | B |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af4 (homo sapiens) (aka alf transcription elongation factor 1)
B: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
C: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
D: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
E: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
F: None of the above. | A |
<Instruct>: Given the context 'LAF-4 encodes a lymphoid nuclear protein with transactivation potential that is homologous to AF-4, the gene fused to MLL in t(4;11) leukemias.
', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mllt7 (homo sapiens) (aka forkhead box o4)
B: mll (homo sapiens) (aka lysine methyltransferase 2a)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
E: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
F: None of the above. | B |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1)
E: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | E |
<Instruct>: Given the context 'A novel human gene, LAF-4, was isolated from a subtracted cDNA library that showed strong sequence similarity to AF-4, a gene that is translocated in t(4;11)(q21;q23) acute lymphoblastic leukemias (ALLs).', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
B: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: None of the above. | C |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
B: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
E: af4/fmr2 family, member 4 (mus musculus) (aka af4/fmr2 family, member 4)
F: None of the above. | C |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
D: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
E: mllt7 (homo sapiens) (aka forkhead box o4)
F: None of the above. | B |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
B: mll1 (homo sapiens) (aka lysine methyltransferase 2a)
C: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
D: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
E: mllt2-like (homo sapiens) (aka alf transcription elongation factor 3)
F: None of the above. | B |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
B: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
C: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
D: mllt7 (homo sapiens) (aka forkhead box o4)
E: mll (mus musculus) (aka lysine (k)-specific methyltransferase 2a)
F: None of the above. | F |
<Instruct>: Given the context 'In t(4;11) ALL, the AF-4 gene at 4q21 is translocated into the MLL locus at 11q23, resulting in the expression of an MLL/AF-4 fusion protein that is the presumptive oncoprotein.', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
B: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
C: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1)
E: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
F: None of the above. | D |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af1 (homo sapiens) (aka ephrin a5)
B: af4 (mus musculus) (af4/fmr2 family, member 1 (mus musculus)) (aka af4/fmr2 family, member 1)
C: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
D: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
E: af4 (homo sapiens) (aka alf transcription elongation factor 1)
F: None of the above. | E |
<Instruct>: Given the context 'AF-4 and LAF-4 are homologous throughout their coding regions, yet neither protein is related to previously cloned genes.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
B: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: af4 (homo sapiens) (aka alf transcription elongation factor 1)
F: None of the above. | D |
<Instruct>: Given the context 'Human LAF-4 readily hybridized with genes in mouse and chicken, thus showing that this gene family has been highly conserved during vertebrate evolution.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
D: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
E: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
F: None of the above. | A |
<Instruct>: Given the context 'In mouse tissues, LAF-4 mRNA was found to be present at highest levels in lymphoid tissues, present at lower levels in brain and lung, and absent from other tissues.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
C: af4 (homo sapiens) (aka alf transcription elongation factor 1)
D: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: None of the above. | B |
<Instruct>: Given the context 'In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
F: None of the above. | D |
<Instruct>: Given the context 'In human and mouse lymphoid cell lines, LAF-4 expression was highest in pre-B cells, intermediate in mature B cells, and absent in plasma cells, thus pointing to a potential regulatory role for LAF-4 in lymphoid development.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
B: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
E: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
F: None of the above. | C |
<Instruct>: Given the context 'Antibodies to LAF-4 showed it to be a nuclear protein that showed an uneven, granular immunofluorescence pattern.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
B: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
C: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
F: None of the above. | D |
<Instruct>: Given the context 'In vitro-translated LAF-4 was able to bind strongly to double-stranded DNA cellulose.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: laf4l (rattus norvegicus) (aka alf transcription elongation factor 4)
C: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
D: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
E: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
F: None of the above. | D |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4 (mus musculus) (aka af4/fmr2 family, member 3)
B: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
C: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
D: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: None of the above. | B |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: transcription factor laf1-like (glycine max) (aka transcription factor laf1-like)
B: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
C: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
D: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
E: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
F: None of the above. | F |
<Instruct>: Given the context 'Furthermore, both LAF-4 and AF-4 had domains that activated transcription strongly when fused to the GAL4 DNA-binding domain.', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
B: af4/fmr2 family member 4 (xenopus tropicalis) (aka af4/fmr2 family member 4)
C: af10 (homo sapiens) (aka mllt10 histone lysine methyltransferase dot1l cofactor)
D: af4 (homo sapiens) (aka alf transcription elongation factor 1)
E: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
F: None of the above. | D |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept corresponding to 'mll'. Answer using one of the provided options. | <Options>: A: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1)
B: mll-af6 (homo sapiens) (aka afadin, adherens junction formation factor)
C: mllt1 super elongation complex subunit (homo sapiens) (aka mllt1 super elongation complex subunit)
D: myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 (mus musculus) (aka myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11)
E: mll (homo sapiens) (aka lysine methyltransferase 2a)
F: None of the above. | E |
<Instruct>: Given the context 'Interestingly, the AF-4 transactivation domain is retained in the MLL/AF-4 fusion protein; thus, it may contribute to the transforming potential of the oncoprotein.', select the correct biomedical concept corresponding to 'af-4'. Answer using one of the provided options. | <Options>: A: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
B: af4 (homo sapiens) (aka alf transcription elongation factor 1)
C: af9 (homo sapiens) (aka mllt3 super elongation complex subunit)
D: af4-2 (drosophila melanogaster) (aka cytochrome p450 6a21)
E: af6 (homo sapiens) (aka afadin, adherens junction formation factor)
F: None of the above. | B |
<Instruct>: Given the context 'Therefore, the cloning of LAF-4 has defined a new family of potential regulatory proteins that may function in lymphoid development and oncogenesis.', select the correct biomedical concept corresponding to 'laf-4'. Answer using one of the provided options. | <Options>: A: laf4 (rattus norvegicus) (aka alf transcription elongation factor 3)
B: laf-4 (mus musculus) (aka af4/fmr2 family, member 3)
C: laf4 (homo sapiens) (aka alf transcription elongation factor 3)
D: aff4 (homo sapiens) (aka alf transcription elongation factor 4)
E: laf4l (mus musculus) (aka af4/fmr2 family, member 4)
F: None of the above. | C |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept corresponding to 'ubc-4'. Answer using one of the provided options. | <Options>: A: ubc4 (saccharomyces cerevisiae s288c) (aka e2 ubiquitin-conjugating protein ubc4)
B: ube2cp4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 c pseudogene 4)
C: ubc8 (homo sapiens) (aka ubiquitin conjugating enzyme e2 h)
D: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
E: ubch4 (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
F: None of the above. | A |
<Instruct>: Given the context 'L-UBC encodes a protein that demonstrates homology to the yeast ubiquitin conjugating enzyme, UBC-4, and human UbcH5.', select the correct biomedical concept corresponding to 'ubch5'. Answer using one of the provided options. | <Options>: A: ubch7 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l3)
B: ubch5a (homo sapiens) (aka ubiquitin conjugating enzyme e2 d1)
C: ubch6 (homo sapiens) (aka ubiquitin conjugating enzyme e2 e1)
D: ube2l5 (homo sapiens) (aka ubiquitin conjugating enzyme e2 l5)
E: ubch5b (homo sapiens) (aka ubiquitin conjugating enzyme e2 d2)
F: None of the above. | B |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept corresponding to 'e2-f1'. Answer using one of the provided options. | <Options>: A: gtf2e2 (gallus gallus) (aka general transcription factor iie subunit 2)
B: e2-f1 (xenopus tropicalis) (aka ubiquitin conjugating enzyme e2 l3)
C: ube2f (homo sapiens) (aka ubiquitin conjugating enzyme e2 f (putative))
D: gtf2f2 (gallus gallus) (aka general transcription factor iif subunit 2)
E: ube2f (gallus gallus) (aka ubiquitin conjugating enzyme e2 f (putative))
F: None of the above. | F |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept corresponding to 'p53'. Answer using one of the provided options. | <Options>: A: p532 (homo sapiens) (aka hect and rld domain containing e3 ubiquitin protein ligase family member 1)
B: rad53 (homo sapiens) (aka checkpoint kinase 2)
C: p53 (homo sapiens) (aka tumor protein p53)
D: tp73 (homo sapiens) (aka tumor protein p73)
E: p53cp (homo sapiens) (aka tumor protein p63)
F: None of the above. | C |
<Instruct>: Given the context 'The protein also exhibits very strong homology to a rabbit protein, E2-F1, which mediates p53 degradation driven by papilloma virus E6 protein in vitro.', select the correct biomedical concept corresponding to 'e6'. Answer using one of the provided options. | <Options>: A: transforming protein e5 (human papillomavirus 16) (aka transforming protein e5)
B: protein e6*;transforming protein e6 (human papillomavirus 16) (aka protein e6*;transforming protein e6)
C: e1^e4 (human papillomavirus 16) (aka cell cycle modulating protein e1^e4)
D: e1 (human papillomavirus 16) (aka replication protein e1)
E: hpve6a (homo sapiens) (aka ubiquitin protein ligase e3a)
F: None of the above. | B |
<Instruct>: Given the context 'Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: autotaxin (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
C: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog)
D: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
E: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
F: None of the above. | A |
<Instruct>: Given the context 'Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
B: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog)
C: transcriptional regulator atrx homolog (xenopus tropicalis) (aka transcriptional regulator atrx homolog)
D: transcriptional regulator atrx homolog (caenorhabditis elegans) (aka transcriptional regulator atrx homolog)
E: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
F: None of the above. | F |
<Instruct>: Given the context 'Cloning, chromosomal localization, and tissue expression of autotaxin from human teratocarcinoma cells.
Autotaxin, a potent human tumor cell motility-stimulating exophosphodiesterase, was isolated and cloned from the human teratocarcinoma cell line NTera2D1.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
B: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
C: transcriptional regulator atrx homolog (xenopus tropicalis) (aka transcriptional regulator atrx homolog)
D: transcriptional regulator atrx homolog (caenorhabditis elegans) (aka transcriptional regulator atrx homolog)
E: autotaxin (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
F: None of the above. | E |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: autotaxina (xenopus tropicalis) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
C: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 l homeolog)
D: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
E: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
F: None of the above. | B |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24.', select the correct biomedical concept corresponding to 'pd-i alpha'. Answer using one of the provided options. | <Options>: A: pd-ialpha (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
B: pdcd1 (homo sapiens) (aka programmed cell death 1)
C: pd-ibeta (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 3)
D: pd-1h (homo sapiens) (aka v-set immunoregulatory receptor)
E: pdcd1l1 (homo sapiens) (aka cd274 molecule)
F: None of the above. | F |
<Instruct>: Given the context 'The deduced amino acid sequence for the teratocarcinoma autotaxin has 94% identity to the melanoma-derived protein, 90% identity to rat brain phosphodiesterase I/nucleotide pyrophosphatase (PD-I alpha), and 44% identity to the plasma cell membrane marker PC-I. Utilizing polymerase chain reaction screening of the CEPH YAC library, we localized the autotaxin gene to human chromosome 8q23-24.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
B: atx1 (arabidopsis thaliana) (homolog of anti-oxidant 1 (arabidopsis thaliana)) (aka homolog of anti-oxidant 1)
C: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
D: autotaxina (xenopus tropicalis) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
E: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
F: None of the above. | C |
<Instruct>: Given the context 'Northern blot analysis of relative mRNA from multiple human tissues revealed that autotaxin mRNA steady state expression is most abundant in brain, placenta, ovary, and small intestine.', select the correct biomedical concept corresponding to 'autotaxin'. Answer using one of the provided options. | <Options>: A: metaxin-1 homolog (caenorhabditis elegans) (aka metaxin-1 homolog)
B: atx1 (arabidopsis thaliana) (homologue of trithorax (arabidopsis thaliana)) (aka homologue of trithorax)
C: autotaxina (xenopus tropicalis) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
D: atx-x (homo sapiens) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2)
E: autotaxin (xenopus laevis) (ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog (xenopus laevis)) (aka ectonucleotide pyrophosphatase/phosphodiesterase 2 s homeolog)
F: None of the above. | D |
<Instruct>: Given the context 'Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit.
', select the correct biomedical concept corresponding to 'osteoclast-specific 116-kda'. Answer using one of the provided options. | <Options>: A: transmembrane protein 116 (xenopus tropicalis) (aka transmembrane protein 116)
B: transmembrane protein 116 (mus musculus) (aka transmembrane protein 116)
C: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
D: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
E: clec-116 (caenorhabditis elegans) (aka c-type lectin domain-containing protein)
F: None of the above. | C |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept corresponding to '116-kda polypeptide subunit of the osteoclastic proton pump'. Answer using one of the provided options. | <Options>: A: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
B: transmembrane protein 116 (xenopus tropicalis) (aka transmembrane protein 116)
C: srh-116 (caenorhabditis elegans) (aka serpentine receptor, class h)
D: v-atpase 116 kda (mus musculus) (aka atpase, h+ transporting, lysosomal v0 subunit a2)
E: v-type proton atpase 116 kda subunit a 1 (caenorhabditis elegans) (aka v-type proton atpase 116 kda subunit a 1)
F: None of the above. | A |
<Instruct>: Given the context 'A cDNA encoding a possible novel human 116-kDa polypeptide subunit of the osteoclastic proton pump (OC-116KDa) has been identified by differential screening of a human osteoclastoma cDNA library.', select the correct biomedical concept corresponding to 'oc-116kda'. Answer using one of the provided options. | <Options>: A: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
B: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
C: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
D: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
E: oc-116kda (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
F: None of the above. | E |
<Instruct>: Given the context 'The predicted sequence of OC-116kDa consists of 822 amino acids and is 46.9% and 47.2% identical at the amino acid level to the 116-KDa polypeptide of the vacuolar proton pump of rat and bovine brain respectively.', select the correct biomedical concept corresponding to 'oc-116kda'. Answer using one of the provided options. | <Options>: A: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
B: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
C: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100355985 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
D: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
E: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
F: None of the above. | E |
<Instruct>: Given the context 'OC-116KDa mRNA was found at high levels in osteoclastomas by Northern analysis but was not detected in tumor stromal cells or in other tissues including kidney, liver, skeletal muscle and brain.', select the correct biomedical concept corresponding to 'oc-116kda'. Answer using one of the provided options. | <Options>: A: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
B: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
C: oc-116 (mus musculus) (aka t cell, immune regulator 1, atpase, h+ transporting, lysosomal v0 protein a3)
D: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
E: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
F: None of the above. | E |
<Instruct>: Given the context 'OC-116KDa mRNA was found at high levels in osteoclastomas by Northern analysis but was not detected in tumor stromal cells or in other tissues including kidney, liver, skeletal muscle and brain.', select the correct biomedical concept corresponding to 'oc-116kda'. Answer using one of the provided options. | <Options>: A: transmembrane protein 116 (oryctolagus cuniculus) (aka transmembrane protein 116)
B: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
C: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
D: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
E: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100343768 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
F: None of the above. | F |
<Instruct>: Given the context 'OC-116KDa mRNA was localized to multinucleated giant cells within the osteoclastoma tumor by in situ hybridization.', select the correct biomedical concept corresponding to 'oc-116kda'. Answer using one of the provided options. | <Options>: A: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176111 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
B: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc108176177 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
C: vomeronasal type-2 receptor 116-like (oryctolagus cuniculus) (loc108176155 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116-like)
D: oc116 (homo sapiens) (aka t cell immune regulator 1, atpase h+ transporting v0 subunit a3)
E: vomeronasal type-2 receptor 116 (oryctolagus cuniculus) (loc100339134 (oryctolagus cuniculus)) (aka vomeronasal type-2 receptor 116)
F: None of the above. | D |
<Instruct>: Given the context 'The ubiquitously expressed pICln protein forms homomeric complexes in vitro.
', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: pinin-like (xenopus tropicalis) (aka pinin-like)
B: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
C: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
D: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
E: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
F: None of the above. | F |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept corresponding to 'icln'. Answer using one of the provided options. | <Options>: A: icln (oryctolagus cuniculus) (aka chloride nucleotide-sensitive channel 1a)
B: icln (xenopus tropicalis) (aka chloride channel, nucleotide-sensitive, 1a)
C: icln (homo sapiens) (chloride nucleotide-sensitive channel 1a (homo sapiens)) (aka chloride nucleotide-sensitive channel 1a)
D: icln (mus musculus) (ibronectin type iii domain containing 10 like (mus musculus)) (aka ibronectin type iii domain containing 10 like)
E: icln (drosophila melanogaster) (aka icln)
F: None of the above. | C |
<Instruct>: Given the context 'The latter current has been associated with the ICln protein (pICln) which may be the chloride channel itself or, alternatively, a channel regulator.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
B: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
C: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
D: picln (drosophila melanogaster) (aka icln)
E: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
F: None of the above. | F |
<Instruct>: Given the context 'We were therefore interested in whether pICln is involved in the endothelial volume-sensitive chloride current.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
B: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
C: cntln (homo sapiens) (aka centlein)
D: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
E: pinin-like (xenopus tropicalis) (aka pinin-like)
F: None of the above. | F |
<Instruct>: Given the context 'As a first step, we have cloned human pICln and studied its expression at the protein level.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: cntln (homo sapiens) (aka centlein)
B: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
C: pinin-like (xenopus tropicalis) (aka pinin-like)
D: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
E: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
F: None of the above. | F |
<Instruct>: Given the context 'Using a polyclonal antiserum raised against human pICln we found a widespread expression of pICln, both in endothelial cells and in other cell lines.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
B: picln (drosophila melanogaster) (aka icln)
C: pinin-like (xenopus tropicalis) (aka pinin-like)
D: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
E: cntln (homo sapiens) (aka centlein)
F: None of the above. | F |
<Instruct>: Given the context 'Using a polyclonal antiserum raised against human pICln we found a widespread expression of pICln, both in endothelial cells and in other cell lines.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
B: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
C: picln (drosophila melanogaster) (aka icln)
D: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
E: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
F: None of the above. | F |
<Instruct>: Given the context 'A characteristic feature of pICln is its anomalous migration during denaturing polyacrylamide gel electrophoresis.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: methylosome subunit picln-like (xenopus laevis) (aka methylosome subunit picln-like)
B: cttn-like (xenopus tropicalis) (aka hematopoietic cell-specific lyn substrate 1)
C: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
D: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
E: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
F: None of the above. | F |
<Instruct>: Given the context 'We also demonstrate that bacterially expressed pICln forms homomeric complexes in vitro.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: pinin-like (xenopus tropicalis) (aka pinin-like)
B: picln (rattus norvegicus) (aka chloride nucleotide-sensitive channel 1a)
C: cntln (homo sapiens) (aka centlein)
D: methylosome subunit picln-like (bos taurus) (aka methylosome subunit picln-like)
E: picln (drosophila melanogaster) (aka icln)
F: None of the above. | F |
<Instruct>: Given the context 'We also demonstrate that bacterially expressed pICln forms homomeric complexes in vitro.', select the correct biomedical concept corresponding to 'picln'. Answer using one of the provided options. | <Options>: A: pinin-like (xenopus tropicalis) (aka pinin-like)
B: methylosome subunit picln (caenorhabditis elegans) (aka methylosome subunit picln)
C: cdkn2a interacting protein n-terminal like (bos taurus) (aka cdkn2a interacting protein n-terminal like)
D: picln (drosophila melanogaster) (aka icln)
E: cdkn2a interacting protein n-terminal like (xenopus tropicalis) (aka cdkn2a interacting protein n-terminal like)
F: None of the above. | F |
<Instruct>: Given the context 'Cloning, sequencing and expression of a novel cDNA encoding human vacuolar ATPase (14-kDa subunit).
', select the correct biomedical concept corresponding to 'vacuolar atpase (14-kda subunit)'. Answer using one of the provided options. | <Options>: A: atp12a (homo sapiens) (aka atpase h+/k+ transporting non-gastric alpha2 subunit)
B: atp6a (homo sapiens) (aka atpase h+/k+ transporting subunit alpha)
C: atp6s14 (homo sapiens) (aka atpase h+ transporting v1 subunit f)
D: atp6v1a (homo sapiens) (aka atpase h+ transporting v1 subunit a)
E: atp6s14-a (xenopus tropicalis) (aka atpase, h+ transporting, lysosomal 14kda, v1 subunit f)
F: None of the above. | C |
<Instruct>: Given the context 'A cDNA encoding the 14-kDa subunit of vacuolar ATPase was cloned from human fetal brain.', select the correct biomedical concept corresponding to '14-kda subunit of vacuolar atpase'. Answer using one of the provided options. | <Options>: A: atp1a4 (homo sapiens) (aka atpase na+/k+ transporting subunit alpha 4)
B: atp6s14 (homo sapiens) (aka atpase h+ transporting v1 subunit f)
C: atp12a (homo sapiens) (aka atpase h+/k+ transporting non-gastric alpha2 subunit)
D: atp14 (saccharomyces cerevisiae s288c) (aka f1f0 atp synthase subunit h)
E: atp6alpha (homo sapiens) (aka activating transcription factor 6)
F: None of the above. | B |
<Instruct>: Given the context 'Molecular cloning and functional analysis of a human cDNA encoding an Escherichia coli AlkB homolog, a protein involved in DNA alkylation damage repair.
', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alk2 (homo sapiens) (aka activin a receptor type 1)
B: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
C: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
D: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
E: alk (homo sapiens) (aka alk receptor tyrosine kinase)
F: None of the above. | F |
<Instruct>: Given the context 'The Escherichia coli AlkB protein is involved in protecting cells against mutation and cell death induced specifically by SN2-type alkylating agents such as methyl methanesulfonate (MMS).', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alk receptor tyrosine kinase (homo sapiens) (aka alk receptor tyrosine kinase)
B: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
C: alk-1 (homo sapiens) (aka activin a receptor like type 1)
D: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
E: alkb (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
F: None of the above. | F |
<Instruct>: Given the context 'A human cDNA encoding a polypeptide homologous to E.coli AlkB was discovered by searching a database of expressed sequence tags (ESTs) derived from high throughput cDNA sequencing.', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alk (homo sapiens) (aka alk receptor tyrosine kinase)
B: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
C: alk2 (homo sapiens) (aka activin a receptor type 1)
D: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
E: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
F: None of the above. | F |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alk (homo sapiens) (aka alk receptor tyrosine kinase)
B: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
C: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
D: alkb (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
E: alk-1 (homo sapiens) (aka activin a receptor like type 1)
F: None of the above. | D |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept corresponding to 'habh'. Answer using one of the provided options. | <Options>: A: abh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
B: habon (homo sapiens) (aka bcl2 interacting protein 3)
C: bah (homo sapiens) (aka aspartate beta-hydroxylase)
D: abhs (homo sapiens) (aka m-phase specific plk1 interacting protein)
E: habp (homo sapiens) (aka hyaluronan binding protein 2)
F: None of the above. | A |
<Instruct>: Given the context 'The full-length human AlkB homolog (hABH) cDNA clone contains a 924 bp open reading frame encoding a 34 kDa protein which is 52% similar and 23% identical to E.coli AlkB.', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alk receptor tyrosine kinase (homo sapiens) (aka alk receptor tyrosine kinase)
B: alk2 (homo sapiens) (aka activin a receptor type 1)
C: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
D: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
E: alk-1 (homo sapiens) (aka activin a receptor like type 1)
F: None of the above. | F |
<Instruct>: Given the context 'The hABH gene, which maps to chromosome 14q24, was ubiquitously expressed in 16 human tissues examined.', select the correct biomedical concept corresponding to 'habh'. Answer using one of the provided options. | <Options>: A: abh1 (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
B: bah (homo sapiens) (aka aspartate beta-hydroxylase)
C: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
D: habp (homo sapiens) (aka hyaluronan binding protein 2)
E: abhs (homo sapiens) (aka m-phase specific plk1 interacting protein)
F: None of the above. | A |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept corresponding to 'habh'. Answer using one of the provided options. | <Options>: A: bah (homo sapiens) (aka aspartate beta-hydroxylase)
B: habh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
C: habp1 (homo sapiens) (aka complement c1q binding protein)
D: habp (homo sapiens) (aka hyaluronan binding protein 2)
E: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
F: None of the above. | B |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept corresponding to 'habh'. Answer using one of the provided options. | <Options>: A: habp1 (homo sapiens) (aka complement c1q binding protein)
B: bah (homo sapiens) (aka aspartate beta-hydroxylase)
C: hab1 (arabidopsis thaliana) (aka hypersensitive to aba1)
D: habp (homo sapiens) (aka hyaluronan binding protein 2)
E: habon (homo sapiens) (aka bcl2 interacting protein 3)
F: None of the above. | F |
<Instruct>: Given the context 'When hABH was expressed in E.coli alkB mutant cells partial rescue of the cells from MMS-induced cell death occurred.', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
B: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
C: alk-1 (homo sapiens) (aka activin a receptor like type 1)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
E: alk2 (homo sapiens) (aka activin a receptor type 1)
F: None of the above. | F |
<Instruct>: Given the context 'Under the conditions used expression of hABH in skin fibroblasts was not regulated by treatment with MMS.', select the correct biomedical concept corresponding to 'habh'. Answer using one of the provided options. | <Options>: A: abhs (homo sapiens) (aka m-phase specific plk1 interacting protein)
B: habp (homo sapiens) (aka hyaluronan binding protein 2)
C: habp1 (homo sapiens) (aka complement c1q binding protein)
D: abh (homo sapiens) (aka alkb homolog 1, histone h2a dioxygenase)
E: bcahh (homo sapiens) (aka lysine methyltransferase 2d)
F: None of the above. | D |
<Instruct>: Given the context 'Our findings show that the AlkB protein is structurally and functionally conserved from bacteria to human, but its regulation may have diverged during evolution.', select the correct biomedical concept corresponding to 'alkb'. Answer using one of the provided options. | <Options>: A: alkb homolog 7 (homo sapiens) (aka alkb homolog 7)
B: alkb homolog 2, alpha-ketoglutarate dependent dioxygenase (homo sapiens) (aka alkb homolog 2, alpha-ketoglutarate dependent dioxygenase)
C: alk-1 (homo sapiens) (aka activin a receptor like type 1)
D: alkb homolog 1, histone h2a dioxygenase (xenopus tropicalis) (aka alkb homolog 1, histone h2a dioxygenase)
E: alkb homolog 1, histone h2a dioxygenase (mus musculus) (aka alkb homolog 1, histone h2a dioxygenase)
F: None of the above. | F |
<Instruct>: Given the context 'Cloning and characterization of human urocortin.
Urocortin, a new member of the CRF peptide family which also includes urotensin I and sauvagine, was recently cloned from the rat midbrain.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (sus scrofa) (aka urocortin)
B: urocortin (rattus norvegicus) (aka urocortin)
C: urocortin (mus musculus) (aka urocortin)
D: urocortin (oryctolagus cuniculus) (aka urocortin)
E: ucn (homo sapiens) (aka urocortin)
F: None of the above. | E |
<Instruct>: Given the context 'Cloning and characterization of human urocortin.
Urocortin, a new member of the CRF peptide family which also includes urotensin I and sauvagine, was recently cloned from the rat midbrain.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (mus musculus) (aka urocortin)
B: urocortin (xenopus tropicalis) (aka urocortin)
C: ucn (homo sapiens) (aka urocortin)
D: urocortin 3 (homo sapiens) (aka urocortin 3)
E: urocortin (sus scrofa) (aka urocortin)
F: None of the above. | C |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (mus musculus) (aka urocortin)
B: urocortin (sus scrofa) (aka urocortin)
C: urocortin (homo sapiens) (aka urocortin)
D: urocortin (xenopus tropicalis) (aka urocortin)
E: urocortin 3 (homo sapiens) (aka urocortin 3)
F: None of the above. | C |
<Instruct>: Given the context 'The synthetic replicate of urocortin was found to bind with high affinity to type 1 and type 2 CRF receptors and, based upon its anatomic localization within the brain, was proposed to be a natural ligand for the type 2 CRF receptors.', select the correct biomedical concept corresponding to 'type 2 crf receptors'. Answer using one of the provided options. | <Options>: A: crf2 (homo sapiens) (aka corticotropin releasing hormone receptor 2)
B: crfr1 (homo sapiens) (aka corticotropin releasing hormone receptor 1)
C: crf-r2 (xenopus tropicalis) (aka corticotropin releasing hormone receptor 2)
D: corticotropin releasing hormone receptor 2 (rattus norvegicus) (aka corticotropin releasing hormone receptor 2)
E: crf2x (homo sapiens) (aka interleukin 22 receptor subunit alpha 2)
F: None of the above. | A |
<Instruct>: Given the context 'Using a genomic library, we have cloned the human counterpart of rat urocortin and localized it to human chromosome 2.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: urocortin (homo sapiens) (aka urocortin)
C: urocortin (sus scrofa) (aka urocortin)
D: urocortin (oryctolagus cuniculus) (aka urocortin)
E: urocortin 3 (homo sapiens) (aka urocortin 3)
F: None of the above. | B |
<Instruct>: Given the context 'Human and rat urocortin share 95% identity within the mature peptide region.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: ucn (homo sapiens) (aka urocortin)
C: urocortin (xenopus tropicalis) (aka urocortin)
D: urocortin (oryctolagus cuniculus) (aka urocortin)
E: urocortin (bos taurus) (aka urocortin)
F: None of the above. | B |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin 2 (homo sapiens) (aka urocortin 2)
B: ucn (homo sapiens) (aka urocortin)
C: urocortin (sus scrofa) (aka urocortin)
D: urocortin (oryctolagus cuniculus) (aka urocortin)
E: urocortin (xenopus tropicalis) (aka urocortin)
F: None of the above. | B |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (mus musculus) (aka urocortin)
B: urocortin (xenopus tropicalis) (aka urocortin)
C: urocortin 2 (homo sapiens) (aka urocortin 2)
D: urocortin (bos taurus) (aka urocortin)
E: urocortin (rattus norvegicus) (aka urocortin)
F: None of the above. | F |
<Instruct>: Given the context 'Synthetic human urocortin binds with high affinity to CRF receptor types 1, 2 alpha, and 2 beta, stimulates cAMP accumulation from cells stably transfected with these receptors, and acts in vitro to release ACTH from dispersed rat anterior pituitary cells.', select the correct biomedical concept corresponding to 'acth'. Answer using one of the provided options. | <Options>: A: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
B: acthr (homo sapiens) (aka melanocortin 2 receptor)
C: acth (mus musculus) (aka pro-opiomelanocortin-alpha)
D: proopiomelanocortin (homo sapiens) (aka proopiomelanocortin)
E: acth1 (rattus norvegicus) (aka proopiomelanocortin)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept corresponding to 'crf-binding protein'. Answer using one of the provided options. | <Options>: A: crhbp (bos taurus) (aka corticotropin releasing hormone binding protein)
B: crfbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
C: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: crhbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
E: None of the above. | D |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (oryctolagus cuniculus) (aka urocortin)
B: ucn (homo sapiens) (aka urocortin)
C: urocortin (sus scrofa) (aka urocortin)
D: urocortin (bos taurus) (aka urocortin)
E: urocortin 3 (homo sapiens) (aka urocortin 3)
F: None of the above. | B |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (mus musculus) (aka urocortin)
B: urocortin 2 (homo sapiens) (aka urocortin 2)
C: urocortin (oryctolagus cuniculus) (aka urocortin)
D: urocortin (homo sapiens) (aka urocortin)
E: urocortin (bos taurus) (aka urocortin)
F: None of the above. | D |
<Instruct>: Given the context 'In addition, the CRF-binding protein binds human urocortin with high affinity and can prevent urocortin-stimulated ACTH secretion in vitro.', select the correct biomedical concept corresponding to 'acth'. Answer using one of the provided options. | <Options>: A: corticotropin releasing hormone (homo sapiens) (aka corticotropin releasing hormone)
B: pomc (homo sapiens) (aka proopiomelanocortin)
C: pro-melanin concentrating hormone (homo sapiens) (aka pro-melanin concentrating hormone)
D: acthr (homo sapiens) (aka melanocortin 2 receptor)
E: acth1 (rattus norvegicus) (aka proopiomelanocortin)
F: None of the above. | B |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept corresponding to 'crf-binding protein'. Answer using one of the provided options. | <Options>: A: crhbp (rattus norvegicus) (aka corticotropin releasing hormone binding protein)
B: crhbp (bos taurus) (aka corticotropin releasing hormone binding protein)
C: crf-rb (homo sapiens) (aka corticotropin releasing hormone receptor 2)
D: crfbp (homo sapiens) (aka corticotropin releasing hormone binding protein)
E: None of the above. | D |
<Instruct>: Given the context 'The inhibitory effect of the CRF-binding protein on human urocortin can be blocked by biologically inactive CRF fragments, such as CRF(9-33).', select the correct biomedical concept corresponding to 'urocortin'. Answer using one of the provided options. | <Options>: A: urocortin (mus musculus) (aka urocortin)
B: urocortin (rattus norvegicus) (aka urocortin)
C: urocortin (sus scrofa) (aka urocortin)
D: urocortin (homo sapiens) (aka urocortin)
E: urocortin (xenopus tropicalis) (aka urocortin)
F: None of the above. | D |
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