instruction stringlengths 169 712 | input stringlengths 140 808 | response stringclasses 6 values |
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<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide and almost no affinity for the central receptor- (CB1) specific antagonist SR 141716A.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
B: bmch2 (mus musculus) (aka bone mechanical trait 2)
C: mcop2 (homo sapiens) (aka visual system homeobox 2)
D: secretoglobin, family 2b, member 2 (mus musculus) (aka secretoglobin, family 2b, member 2)
E: mc2 (homo sapiens) (aka melanocortin 5 receptor)
F: None of the above. | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide and almost no affinity for the central receptor- (CB1) specific antagonist SR 141716A.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: bmc2 (mus musculus) (aka bone mineral content 2)
B: bmch2 (mus musculus) (aka bone mechanical trait 2)
C: mcb1 (homo sapiens) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 4)
D: mcop2 (homo sapiens) (aka visual system homeobox 2)
E: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
F: None of the above. | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide and almost no affinity for the central receptor- (CB1) specific antagonist SR 141716A.', select the correct biomedical concept corresponding to 'hcb2'. Answer using one of the provided options. | <Options>: A: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
B: fhcb2 (homo sapiens) (aka low density lipoprotein receptor adaptor protein 1)
C: csnb2b (homo sapiens) (aka calcium binding protein 4)
D: cpeb2 (homo sapiens) (aka cytoplasmic polyadenylation element binding protein 2)
E: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
F: None of the above. | F |
<Instruct>: Given the context 'Binding experiments with membranes from COS-3 cells transiently expressing mCB2 showed that the synthetic cannabinoid WIN 55212-2 had a 6-fold lower affinity for mCB2 than for hCB2, whereas both receptors showed similar affinities for the agonists CP 55,940, delta(9)-THC and anandamide and almost no affinity for the central receptor- (CB1) specific antagonist SR 141716A.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options. | <Options>: A: cannabinoid receptor 1 (rattus norvegicus) (aka cannabinoid receptor 1)
B: cannabinoid receptor 1 (homo sapiens) (aka cannabinoid receptor 1)
C: cb1 (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | B |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept corresponding to 'hcb2'. Answer using one of the provided options. | <Options>: A: hcn2 (homo sapiens) (aka hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2)
B: protocadherin beta 2 (homo sapiens) (aka protocadherin beta 2)
C: mopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
D: cgb2 (homo sapiens) (aka chorionic gonadotropin subunit beta 2)
E: csnb2b (homo sapiens) (aka calcium binding protein 4)
F: None of the above. | F |
<Instruct>: Given the context 'Both hCB2 and mCB2 mediate agonist-stimulated inhibition of forskolin-induced cAMP production in CHO cell lines permanently expressing the receptors.', select the correct biomedical concept corresponding to 'mcb2'. Answer using one of the provided options. | <Options>: A: mc2dn2 (homo sapiens) (aka succinate dehydrogenase complex assembly factor 1)
B: mcopcb2 (homo sapiens) (aka microphthalmia, colobomatous, 2)
C: bmc2 (mus musculus) (aka bone mineral content 2)
D: mc2 (homo sapiens) (aka melanocortin 5 receptor)
E: mcop2 (homo sapiens) (aka visual system homeobox 2)
F: None of the above. | F |
<Instruct>: Given the context 'SR 141716A failed to antagonize this activity in either cell line, confirming its specificity for CB1.', select the correct biomedical concept corresponding to 'cb1'. Answer using one of the provided options. | <Options>: A: cb1a (homo sapiens) (aka cannabinoid receptor 1)
B: cb1 (rattus norvegicus) (aka cannabinoid receptor 1)
C: cb1a (mus musculus) (aka cannabinoid receptor 1)
D: None of the above. | A |
<Instruct>: Given the context 'The human glycine receptor beta subunit: primary structure, functional characterisation and chromosomal localisation of the human and murine genes.
', select the correct biomedical concept corresponding to 'glycine receptor beta'. Answer using one of the provided options. | <Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: glycine receptor beta (bos taurus) (aka glycine receptor beta)
C: glycine receptor beta (xenopus tropicalis) (aka glycine receptor beta)
D: guanine nucleotide-binding protein subunit beta (glycine max) (aka guanine nucleotide-binding protein subunit beta)
E: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
F: None of the above. | E |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with the human GlyR alpha 1 subunit.', select the correct biomedical concept corresponding to 'beta subunit of the human glyr'. Answer using one of the provided options. | <Options>: A: glyb (homo sapiens) (aka solute carrier family 25 member 32)
B: gprc1b (homo sapiens) (aka glutamate metabotropic receptor 2)
C: gabbr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
D: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
E: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
F: None of the above. | D |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with the human GlyR alpha 1 subunit.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor beta (bos taurus) (aka glycine receptor beta)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
E: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
F: None of the above. | E |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with the human GlyR alpha 1 subunit.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
C: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
D: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
E: glycine receptor beta (bos taurus) (aka glycine receptor beta)
F: None of the above. | A |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with the human GlyR alpha 1 subunit.', select the correct biomedical concept corresponding to 'glyr alpha 1'. Answer using one of the provided options. | <Options>: A: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
B: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 l homeolog (xenopus laevis)) (aka glycine receptor alpha 1 l homeolog)
C: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
D: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
E: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
F: None of the above. | C |
<Instruct>: Given the context 'A 2106 bp cDNA, isolated from a human hippocampal cDNA library, contained an open reading frame of 497 amino acids which encodes the beta subunit of the human GlyR. The mature human GlyR beta polypeptide displays 99% amino acid identity with the rat GlyR beta subunit and 48% identity with the human GlyR alpha 1 subunit.', select the correct biomedical concept corresponding to 'glyr alpha 1'. Answer using one of the provided options. | <Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: glycine receptor alpha 1 (xenopus tropicalis) (aka glycine receptor alpha 1)
C: glyr-a1 (xenopus laevis) (glycine receptor alpha 1 s homeolog (xenopus laevis)) (aka glycine receptor alpha 1 s homeolog)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: glycine receptor, alpha 1 (rattus norvegicus) (aka glycine receptor, alpha 1)
F: None of the above. | F |
<Instruct>: Given the context 'Neither [3H]strychnine binding nor glycine-gated currents were detected when the human GlyR beta subunit cDNA was expressed in the human embryonic kidney 293 cell line.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
B: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
C: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
D: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
F: None of the above. | B |
<Instruct>: Given the context 'However, co-expression of the beta subunit cDNA with the alpha 1 subunit cDNA resulted in expression of functional GlyRs which showed a 4-fold reduction in the EC50 values when compared to alpha 1 homomeric GlyRs.', select the correct biomedical concept corresponding to 'alpha 1 homomeric glyrs'. Answer using one of the provided options. | <Options>: A: glycine receptor, alpha 1 (rattus norvegicus) (aka glycine receptor, alpha 1)
B: guanine nucleotide-binding protein alpha-1 subunit (glycine max) (aka guanine nucleotide-binding protein alpha-1 subunit)
C: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
D: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
E: gamma-aminobutyric acid type a receptor subunit alpha1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit alpha1)
F: None of the above. | C |
<Instruct>: Given the context 'Glycine-gated currents of alpha 1/beta GlyRs were 17-fold less sensitive than homomeric alpha 1 GlyRs to the antagonists picrotoxin, picrotoxinin and picrotin, providing clear evidence that heteromeric alpha 1/beta GlyRs were expressed.', select the correct biomedical concept corresponding to 'alpha 1 glyrs'. Answer using one of the provided options. | <Options>: A: glyrs (homo sapiens) (aka glycyl-trna synthetase 1)
B: glycine receptor alpha 1 (homo sapiens) (aka glycine receptor alpha 1)
C: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
D: alpha1aar (homo sapiens) (aka adrenoceptor alpha 1a)
E: glycine receptor alpha 1 (sus scrofa) (aka glycine receptor alpha 1)
F: None of the above. | B |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: gababr2 (homo sapiens) (aka gamma-aminobutyric acid type b receptor subunit 2)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: glrb (homo sapiens) (aka glycine receptor beta)
E: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
F: None of the above. | D |
<Instruct>: Given the context 'Fluorescence in situ hybridisation was used to localise the gene encoding the human GlyR beta subunit (GLRB) to chromosome 4q32, a position syntenic with mouse chromosome 3.', select the correct biomedical concept corresponding to 'glrb'. Answer using one of the provided options. | <Options>: A: glrb (xenopus tropicalis) (aka glycine receptor beta)
B: gl-r (homo sapiens) (aka glucagon receptor)
C: glrb (bos taurus) (aka glycine receptor beta)
D: glrb (homo sapiens) (aka glycine receptor beta)
E: glr (homo sapiens) (aka glycine receptor alpha 2)
F: None of the above. | D |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
B: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
C: glycine receptor, beta (rattus norvegicus) (aka glycine receptor, beta)
D: glrb (homo sapiens) (aka glycine receptor beta)
E: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
B: gprc2b (homo sapiens) (aka vomeronasal 2 receptor 1 pseudogene)
C: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
D: gprg1b (homo sapiens) (aka g protein-coupled receptor 142)
E: glycine receptor beta (bos taurus) (aka glycine receptor beta)
F: None of the above. | F |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'glrb'. Answer using one of the provided options. | <Options>: A: glrb (mus musculus) (aka glycine receptor, beta subunit)
B: glrb (homo sapiens) (aka glycine receptor beta)
C: gabrb1 (homo sapiens) (aka gamma-aminobutyric acid type a receptor subunit beta1)
D: glrb (xenopus tropicalis) (aka glycine receptor beta)
E: gl-r (homo sapiens) (aka glucagon receptor)
F: None of the above. | A |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spastic'. Answer using one of the provided options. | <Options>: A: spastic paraplegia 16 (complicated, x-linked recessive) (homo sapiens) (aka spastic paraplegia 16 (complicated, x-linked recessive))
B: spasm (homo sapiens) (aka kantr integral membrane protein)
C: spastic (mus musculus) (aka glycine receptor, beta subunit)
D: hyperreflexia (homo sapiens) (aka hyperreflexia)
E: spastic paraplegia 24 (autosomal recessive) (homo sapiens) (aka spastic paraplegia 24 (autosomal recessive))
F: None of the above. | C |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spas1 (homo sapiens) (aka spermatogenesis associated 19)
B: spa (homo sapiens) (aka surfactant protein a1)
C: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
D: spalpha (homo sapiens) (aka cd5 molecule like)
E: spaii (homo sapiens) (aka surfactant protein a2)
F: None of the above. | F |
<Instruct>: Given the context 'In situ hybridisation using the human GlyR beta subunit cDNA showed that the murine GlyR beta subunit gene (Glrb) maps to the spastic (spa) locus on mouse chromosome 3 at bands E3-F1.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spap (homo sapiens) (aka pdzk1 interacting protein 1)
B: spap1a (homo sapiens) (aka fc receptor like 2)
C: spalpha (homo sapiens) (aka cd5 molecule like)
D: spas1 (homo sapiens) (aka spermatogenesis associated 19)
E: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
F: None of the above. | F |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept corresponding to 'glyr beta'. Answer using one of the provided options. | <Options>: A: glycine receptor beta (homo sapiens) (aka glycine receptor beta)
B: glyr1 (homo sapiens) (aka glyoxylate reductase 1 homolog)
C: glycine receptor beta (sus scrofa) (aka glycine receptor beta)
D: glycine receptor beta (bos taurus) (aka glycine receptor beta)
E: receptor for activated c kinase 1b (glycine max) (aka receptor for activated c kinase 1b)
F: None of the above. | F |
<Instruct>: Given the context 'This is consistent with the recent finding that a mutation in the murine GlyR beta subunit causes the spa phenotype.', select the correct biomedical concept corresponding to 'spa'. Answer using one of the provided options. | <Options>: A: spalpha (homo sapiens) (aka cd5 molecule like)
B: spaar (homo sapiens) (aka small regulatory polypeptide of amino acid response)
C: spax1 (homo sapiens) (aka vesicle associated membrane protein 1)
D: spam (homo sapiens) (aka eyes shut homolog)
E: spas1 (homo sapiens) (aka spermatogenesis associated 19)
F: None of the above. | F |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: p1-cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
B: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
C: cdc16 (homo sapiens) (aka cell division cycle 16)
D: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
E: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
F: None of the above. | A |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: hcp26 (homo sapiens) (aka cycs pseudogene 26)
B: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cell division cycle 26 (homo sapiens) (aka cell division cycle 26)
E: cdc16 (homo sapiens) (aka cell division cycle 16)
F: None of the above. | C |
<Instruct>: Given the context 'Coding sequence and chromosome mapping of the human gene (CDC46) for replication protein hCdc46/Mcm5.
', select the correct biomedical concept corresponding to 'mcm5'. Answer using one of the provided options. | <Options>: A: mcm5 (homo sapiens) (aka minichromosome maintenance complex component 5)
B: minichromosome maintenance 5 (drosophila melanogaster) (aka minichromosome maintenance 5)
C: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna replication licensing factor mcm-5)
D: mcm dna helicase complex subunit mcm5 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
E: mcm6 (homo sapiens) (aka minichromosome maintenance complex component 6)
F: None of the above. | A |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
B: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
C: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
D: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
E: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
F: None of the above. | C |
<Instruct>: Given the context 'We have isolated the complete cDNA sequence encoding the human homolog of the yeast replication protein Cdc46/Mcm5.', select the correct biomedical concept corresponding to 'mcm5'. Answer using one of the provided options. | <Options>: A: cdc5 (homo sapiens) (aka cell division cycle 5 like)
B: mcm6 (homo sapiens) (aka minichromosome maintenance complex component 6)
C: mcm5 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
D: dna replication licensing factor mcm-5 (caenorhabditis elegans) (aka dna replication licensing factor mcm-5)
E: minichromosome maintenance complex component 5 (mus musculus) (aka minichromosome maintenance complex component 5)
F: None of the above. | C |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cdc46 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm5)
B: p1-cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
D: mcm dna helicase complex subunit mcm6 (saccharomyces cerevisiae s288c) (aka mcm dna helicase complex subunit mcm6)
E: anaphase promoting complex subunit cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
F: None of the above. | B |
<Instruct>: Given the context 'The cDNA was used as a probe for chromosomal fluorescence in situ hybridization (FISH), which localized the human Cdc46 gene (CDC46) to chromosome region 22q13.1-->q13.2.', select the correct biomedical concept corresponding to 'cdc46'. Answer using one of the provided options. | <Options>: A: cdc16 (saccharomyces cerevisiae s288c) (aka anaphase promoting complex subunit cdc16)
B: aaa family atpase cdc6 (saccharomyces cerevisiae s288c) (aka aaa family atpase cdc6)
C: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
D: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
E: cdc47 (homo sapiens) (aka minichromosome maintenance complex component 7)
F: None of the above. | C |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
B: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
C: cell division cycle 26 (homo sapiens) (aka cell division cycle 26)
D: cdc16 (homo sapiens) (aka cell division cycle 16)
E: hcp26 (homo sapiens) (aka cycs pseudogene 26)
F: None of the above. | B |
<Instruct>: Given the context 'As deduced from the cDNA sequence, human protein hCdc46 is composed of 734 amino acids and contains a central region that is almost 80% identical with the yeast protein.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: ccdc46 (homo sapiens) (aka centrosomal protein 112)
C: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
D: cell division cycle 26 (homo sapiens) (aka cell division cycle 26)
E: cdc6 (homo sapiens) (aka cell division cycle 6)
F: None of the above. | F |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: ccdc56 (homo sapiens) (aka cytochrome c oxidase assembly factor 3)
B: hcp26 (homo sapiens) (aka cycs pseudogene 26)
C: ccdc46 (homo sapiens) (aka centrosomal protein 112)
D: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
E: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
F: None of the above. | D |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'hcdc46'. Answer using one of the provided options. | <Options>: A: cell division cycle protein 16 homolog (caenorhabditis elegans) (aka cell division cycle protein 16 homolog)
B: hcp26 (homo sapiens) (aka cycs pseudogene 26)
C: cdc16 (homo sapiens) (aka cell division cycle 16)
D: cdc46 (homo sapiens) (aka minichromosome maintenance complex component 5)
E: cdc36 (homo sapiens) (aka ccr4-not transcription complex subunit 2)
F: None of the above. | D |
<Instruct>: Given the context 'Immunoprecipitation experiments with hCdc46-specific antibodies confirm that essentially all nuclear hCdc46 proteins form a stable dimeric complex with protein P1Mcm3.', select the correct biomedical concept corresponding to 'p1mcm3'. Answer using one of the provided options. | <Options>: A: chmp3 (mus musculus) (aka charged multivesicular body protein 3)
B: mcm3 (mus musculus) (aka minichromosome maintenance complex component 3)
C: p1-mcm3 (homo sapiens) (aka minichromosome maintenance complex component 3)
D: mmcp-3 (mus musculus) (aka mast cell protease 3)
E: cnnm3 (mus musculus) (aka cyclin m3)
F: None of the above. | C |
<Instruct>: Given the context 'We report herein the presence of kappa opioid receptors (KORs) in human fetal microglia and inhibition of HIV-1 expression in acutely infected microglial cell cultures treated with KOR ligands.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
B: kor3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
D: oprk (homo sapiens) (aka opioid receptor kappa 1)
E: kor (mus musculus) (aka opioid receptor, kappa 1)
F: None of the above. | D |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
B: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
C: kor (mus musculus) (aka opioid receptor, kappa 1)
D: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
E: oprk (homo sapiens) (aka opioid receptor kappa 1)
F: None of the above. | E |
<Instruct>: Given the context 'Using reverse transcriptase-polymerase chain reaction and sequencing analyses, we found that mRNA for the KOR was constitutively expressed in microglia and determined that the nucleotide sequence of the open reading frame was identical to that of the human brain KOR gene.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor (homo sapiens) (aka opioid receptor kappa 1)
B: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
C: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
F: None of the above. | A |
<Instruct>: Given the context 'The expression of KOR in microglial cells was confirmed by membrane binding of [3H]U69,593, a kappa-selective ligand, and by indirect immunofluorescence.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: kor (homo sapiens) (aka opioid receptor kappa 1)
B: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
C: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
D: kor (mus musculus) (aka opioid receptor, kappa 1)
E: kor3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'This antiviral effect of the kappa ligands was blocked by the specific KOR antagonist, nor-binaltrophimine.', select the correct biomedical concept corresponding to 'kor'. Answer using one of the provided options. | <Options>: A: oprk1 (rattus norvegicus) (aka opioid receptor, kappa 1)
B: kor (mus musculus) (aka opioid receptor, kappa 1)
C: oprk (homo sapiens) (aka opioid receptor kappa 1)
D: kor-3 (rattus norvegicus) (aka opioid related nociceptin receptor 1)
E: kor-3 (homo sapiens) (aka opioid related nociceptin receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'p97 subunit of the 26s proteasome'. Answer using one of the provided options. | <Options>: A: rp97 (homo sapiens) (aka von willebrand factor a domain containing 8)
B: p95 (homo sapiens) (aka nibrin)
C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
D: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: None of the above. | C |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor-receptor-associated protein-2'. Answer using one of the provided options. | <Options>: A: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
B: trap2 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
D: tnf receptor associated factor 2 (homo sapiens) (aka tnf receptor associated factor 2)
E: inositol 1,4,5-triphosphate receptor associated 2 (homo sapiens) (aka inositol 1,4,5-triphosphate receptor associated 2)
F: None of the above. | B |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor-receptor-associated protein-2'. Answer using one of the provided options. | <Options>: A: rna polymerase ii associated protein 2 (homo sapiens) (aka rna polymerase ii associated protein 2)
B: thrap2 (homo sapiens) (aka mediator complex subunit 13l)
C: rad51 associated protein 2 (homo sapiens) (aka rad51 associated protein 2)
D: traf2 (homo sapiens) (tnf receptor associated factor 2 (homo sapiens)) (aka tnf receptor associated factor 2)
E: inositol 1,4,5-triphosphate receptor associated 2 (homo sapiens) (aka inositol 1,4,5-triphosphate receptor associated 2)
F: None of the above. | F |
<Instruct>: Given the context 'cDNA cloning and functional analysis of the p97 subunit of the 26S proteasome, a polypeptide identical to the type-1 tumor-necrosis-factor-receptor-associated protein-2/55.11.
', select the correct biomedical concept corresponding to '55.11'. Answer using one of the provided options. | <Options>: A: ct55 (homo sapiens) (aka cancer/testis antigen 55)
B: testis expressed 55 (homo sapiens) (aka testis expressed 55)
C: gp55 (homo sapiens) (aka neuroplastin)
D: hel55 (homo sapiens) (aka heat shock protein family b (small) member 6)
E: gm5511 (mus musculus) (aka predicted gene 5511)
F: None of the above. | F |
<Instruct>: Given the context 'Molecular cloning of cDNA for a new regulatory subunit, designated p97, of the human 26S proteasome showed that the polypeptide consists of 908 amino acid residues with a calculated molecular mass of 100184 Da and an isoelectric point of 4.94.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
B: map97 (homo sapiens) (aka melanotransferrin)
C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
D: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | E |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
D: p97 (bos taurus) (aka valosin containing protein)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | E |
<Instruct>: Given the context 'Computer analysis showed that p97 is very similar to type-1 tumor-necrosis-factor (TNF)-receptor-associated protein (TRAP)-2 and 55.11, both of which were identified recently as binding proteins of the cytoplasmic domain of type-1 TNF receptor by yeast two-hybrid screening.', select the correct biomedical concept corresponding to 'type-1 tumor-necrosis-factor (tnf)-receptor-associated protein (trap)-2'. Answer using one of the provided options. | <Options>: A: receptor accessory protein 2 (homo sapiens) (aka receptor accessory protein 2)
B: rna polymerase ii associated protein 2 (homo sapiens) (aka rna polymerase ii associated protein 2)
C: tra2a (homo sapiens) (aka transformer 2 alpha homolog)
D: trap2 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
E: tra2b (homo sapiens) (aka transformer 2 beta homolog)
F: None of the above. | D |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (bos taurus) (aka valosin containing protein)
B: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
D: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
E: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
F: None of the above. | E |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'nas1'. Answer using one of the provided options. | <Options>: A: nars (homo sapiens) (aka asparaginyl-trna synthetase 1)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: anorexia nervosa, susceptibility to, 1 (homo sapiens) (aka anorexia nervosa, susceptibility to, 1)
D: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
E: nas1 (homo sapiens) (solute carrier family 13 member 1 (homo sapiens)) (aka solute carrier family 13 member 1)
F: None of the above. | D |
<Instruct>: Given the context 'Computer-assisted similarity analysis also revealed the high sequence similarity of p97 with a yeast protein whose function is yet unknown, the gene for which is here termed NAS1 (non-ATPase subunit 1).', select the correct biomedical concept corresponding to 'non-atpase subunit 1'. Answer using one of the provided options. | <Options>: A: nop protein chaperone 1 (homo sapiens) (aka nop protein chaperone 1)
B: matrix non-peptidase homolog 1 (caenorhabditis elegans) (aka matrix non-peptidase homolog 1)
C: nonu-1 (caenorhabditis elegans) (aka smr domain-containing protein)
D: cytosolic fe-s cluster assembly factor nubp1 homolog (caenorhabditis elegans) (aka cytosolic fe-s cluster assembly factor nubp1 homolog)
E: atp synthase membrane subunit c locus 1 (homo sapiens) (aka atp synthase membrane subunit c locus 1)
F: None of the above. | F |
<Instruct>: Given the context 'Disruption of NAS1 resulted in several phenotypes, including lethality and temperature-sensitive growth, depending on the genetic background of the cells used.', select the correct biomedical concept corresponding to 'nas1'. Answer using one of the provided options. | <Options>: A: nars1 (homo sapiens) (aka asparaginyl-trna synthetase 1)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: nas1 (arabidopsis thaliana) (aka nicotianamine synthase 1)
D: nas1 (homo sapiens) (nr2f1 regulatory antisense rna 1 (homo sapiens)) (aka nr2f1 regulatory antisense rna 1)
E: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
F: None of the above. | E |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
B: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
C: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
D: p97 (drosophila melanogaster) (transitional endoplasmic reticulum 94 (drosophila melanogaster)) (aka transitional endoplasmic reticulum 94)
E: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
F: None of the above. | B |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
B: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
C: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
D: ec97 (homo sapiens) (aka vps35 endosomal protein sorting factor like)
E: hspc97 (homo sapiens) (aka tubulin gamma complex component 2)
F: None of the above. | C |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (bos taurus) (aka valosin containing protein)
B: map97 (homo sapiens) (aka melanotransferrin)
C: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
D: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
E: p97 (drosophila melanogaster) (regulatory particle non-atpase 1 (drosophila melanogaster)) (aka regulatory particle non-atpase 1)
F: None of the above. | F |
<Instruct>: Given the context 'The human p97 cDNA suppressed the growth defect of nas1 disruptant cells, when expressed from single-copy or multi-copy vectors, indicating that p97 is functionally equivalent to yeast Nas1p.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
B: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
C: nas6p (saccharomyces cerevisiae s288c) (aka nas6p)
D: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
E: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
F: None of the above. | D |
<Instruct>: Given the context 'Culturing of the temperature-sensitive nas1 cells at the restrictive temperature promoted the accumulation polyubiquitinated cellular proteins, implying that the 26S proteasome requires a functional Nas1p subunit for ubiquitin-dependent proteolysis.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nas5 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn5)
B: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
C: nas7 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn9)
D: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
E: nas1 (xenopus tropicalis) (aka solute carrier family 13 member 1)
F: None of the above. | B |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept corresponding to 'p97'. Answer using one of the provided options. | <Options>: A: p97 (homo sapiens) (proteasome 26s subunit ubiquitin receptor, non-atpase 2 (homo sapiens)) (aka proteasome 26s subunit ubiquitin receptor, non-atpase 2)
B: hspc197 (homo sapiens) (aka bet1 golgi vesicular membrane trafficking protein like)
C: (vcp)/p97 (drosophila melanogaster) (aka transitional endoplasmic reticulum 94)
D: p97 (homo sapiens) (valosin containing protein (homo sapiens)) (aka valosin containing protein)
E: map97 (homo sapiens) (aka melanotransferrin)
F: None of the above. | A |
<Instruct>: Given the context 'These results indicate that p97/Nas1p plays an important regulatory role in the function of the 26S proteasome.', select the correct biomedical concept corresponding to 'nas1p'. Answer using one of the provided options. | <Options>: A: nas1 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle base subunit rpn1)
B: nas2p (saccharomyces cerevisiae s288c) (aka nas2p)
C: nas4 (saccharomyces cerevisiae s288c) (aka proteasome regulatory particle lid subunit rpn6)
D: nas1 (xenopus laevis) (solute carrier family 13 member 1 s homeolog (xenopus laevis)) (aka solute carrier family 13 member 1 s homeolog)
E: nasp (homo sapiens) (aka nuclear autoantigenic sperm protein)
F: None of the above. | A |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgfbeta (homo sapiens) (aka transforming growth factor beta 1)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | A |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'transforming growth factor-beta'. Answer using one of the provided options. | <Options>: A: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
B: transforming growth factor beta receptor 3 (homo sapiens) (aka transforming growth factor beta receptor 3)
C: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
D: transforming growth factor beta 1 (xenopus tropicalis) (aka transforming growth factor beta 1)
E: tgfb (homo sapiens) (aka transforming growth factor beta 1)
F: None of the above. | E |
<Instruct>: Given the context 'Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
Transforming growth factor-beta TGF-beta is the prototype for a family of extracellular proteins that affect cell proliferation and tissue differentiation.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
B: transforming growth factor beta 1 (homo sapiens) (aka transforming growth factor beta 1)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | B |
<Instruct>: Given the context 'TGF-beta-related factors, including BMP-2/4, Dpp and activin, act through two types of serine/threonine kinase receptors which can form a heteromeric complex.', select the correct biomedical concept corresponding to 'dpp'. Answer using one of the provided options. | <Options>: A: dppi (homo sapiens) (aka cathepsin c)
B: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
C: dppiii (homo sapiens) (aka dipeptidyl peptidase 3)
D: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
E: None of the above. | E |
<Instruct>: Given the context 'In Drosophila, Mad is required for signalling by Dpp.', select the correct biomedical concept corresponding to 'dpp'. Answer using one of the provided options. | <Options>: A: dpp (homo sapiens) (dipeptidyl peptidase 7 (homo sapiens)) (aka dipeptidyl peptidase 7)
B: dpp (drosophila melanogaster) (dipeptidyl aminopeptidase iii (drosophila melanogaster)) (aka dipeptidyl aminopeptidase iii)
C: dppiii (homo sapiens) (aka dipeptidyl peptidase 3)
D: dppi (homo sapiens) (aka cathepsin c)
E: None of the above. | E |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
B: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
C: madh4 (homo sapiens) (aka smad family member 4)
D: mad4 (homo sapiens) (aka max dimerization protein 4)
E: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: None of the above. | C |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: mad4 (homo sapiens) (aka max dimerization protein 4)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
D: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
E: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
F: None of the above. | F |
<Instruct>: Given the context 'We have isolated complementary DNAs for four human Mad homologues, one of which, hMAD-4, is identical to DPC-4, a candidate tumour suppressor.', select the correct biomedical concept corresponding to 'dpc-4'. Answer using one of the provided options. | <Options>: A: dpc4 (mus musculus) (aka smad family member 4)
B: dpc4 (xenopus laevis) (smad family member 4 s homeolog (xenopus laevis)) (aka smad family member 4 s homeolog)
C: ciliary dyskinesia, primary, 4 (homo sapiens) (aka ciliary dyskinesia, primary, 4)
D: defective pharyngeal development protein 4 (caenorhabditis elegans) (aka defective pharyngeal development protein 4)
E: dpc4 (homo sapiens) (aka smad family member 4)
F: None of the above. | E |
<Instruct>: Given the context 'hMAD-3 and -4 synergized to induce strong ligand-independent TGF-beta-like responses.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
B: ifn-beta (homo sapiens) (aka interferon beta 1)
C: tgfbeta (homo sapiens) (aka transforming growth factor beta 1)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | C |
<Instruct>: Given the context 'When truncated at their carboxy termini, hMAD-3 and -4 act as dominant-negative inhibitors of the normal TGF-beta response.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: ifn-beta (homo sapiens) (aka interferon beta 1)
B: tgf-beta1 (homo sapiens) (aka transforming growth factor beta 1)
C: tgf-beta2 (homo sapiens) (aka transforming growth factor beta 2)
D: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
E: None of the above. | B |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
B: transforming growth factor beta 3 (homo sapiens) (aka transforming growth factor beta 3)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: tgfb1 (homo sapiens) (aka transforming growth factor beta 1)
E: None of the above. | D |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'hmad-3'. Answer using one of the provided options. | <Options>: A: mad-3 (homo sapiens) (aka nfkb inhibitor alpha)
B: amd3 (homo sapiens) (aka bone morphogenetic protein receptor type 1b)
C: dmhdac3 (drosophila melanogaster) (aka histone deacetylase 3)
D: hmad-3 (homo sapiens) (aka smad family member 3)
E: hmad-2 (homo sapiens) (aka smad family member 2)
F: None of the above. | D |
<Instruct>: Given the context 'The activity of hMAD-3 and -4 was regulated by the TGF-beta receptors, and hMAD-3 but not hMAD-4 was phosphorylated and associated with the ligand-bound receptor complex.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (homo sapiens) (aka smad family member 4)
B: mamdc4 (homo sapiens) (aka mam domain containing 4)
C: mad4 (homo sapiens) (aka max dimerization protein 4)
D: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
E: ahd-4 (mus musculus) (aka aldehyde dehydrogenase family 3, subfamily a1)
F: None of the above. | A |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'tgf-beta'. Answer using one of the provided options. | <Options>: A: tgfb (homo sapiens) (aka transforming growth factor beta 1)
B: tgf-beta3 (homo sapiens) (aka transforming growth factor beta 3)
C: ifn-beta (homo sapiens) (aka interferon beta 1)
D: transforming growth factor beta 2 (homo sapiens) (aka transforming growth factor beta 2)
E: None of the above. | A |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'dpca-4'. Answer using one of the provided options. | <Options>: A: cpamd4 (homo sapiens) (aka complement c5)
B: cell division cycle associated 4 (homo sapiens) (aka cell division cycle associated 4)
C: hda-4 (caenorhabditis elegans) (aka histone deacetylase 4)
D: cell division cycle associated 4 (xenopus tropicalis) (aka cell division cycle associated 4)
E: dpc4 (homo sapiens) (aka smad family member 4)
F: None of the above. | E |
<Instruct>: Given the context 'These results define hMAD-3 and -4 as effectors of the TGF-beta response and demonstrate a function for DPCA-4/hMAD-4 as a tumour suppressor.', select the correct biomedical concept corresponding to 'hmad-4'. Answer using one of the provided options. | <Options>: A: smad family member 4 (homo sapiens) (aka smad family member 4)
B: cadm4 (homo sapiens) (aka cell adhesion molecule 4)
C: amd4 (homo sapiens) (aka protein kinase cgmp-dependent 2)
D: odad4 (homo sapiens) (aka outer dynein arm docking complex subunit 4)
E: mamdc4 (homo sapiens) (aka mam domain containing 4)
F: None of the above. | A |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept corresponding to 'c5a chemoattractant receptor'. Answer using one of the provided options. | <Options>: A: c5ar (homo sapiens) (aka complement c5a receptor 1)
B: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
C: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
D: c5ar1 (bos taurus) (aka complement c5a receptor 1)
E: c5ar (mus musculus) (aka complement component 5a receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'The C5a chemoattractant receptor mediates mucosal defence to infection.
', select the correct biomedical concept corresponding to 'c5a chemoattractant receptor'. Answer using one of the provided options. | <Options>: A: c5ar1 (bos taurus) (aka complement c5a receptor 1)
B: c5ar1 (mus musculus) (aka complement component 5a receptor 1)
C: c5ar2 (homo sapiens) (aka complement c5a receptor 2)
D: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
E: None of the above. | E |
<Instruct>: Given the context 'A family of G-protein-coupled chemoattractant receptors is known to mediate the transport and activation of neutrophils and macrophages This family includes receptors for chemokines, such as interleukin-8, bacterial formylated peptides, platelet-activating factor, leukotriene B4, and the complement anaphylatoxins.', select the correct biomedical concept corresponding to 'interleukin-8'. Answer using one of the provided options. | <Options>: A: il18 (homo sapiens) (aka interleukin 18)
B: ck-8 (homo sapiens) (aka keratin 8)
C: scya8 (homo sapiens) (aka c-c motif chemokine ligand 8)
D: il1f8 (homo sapiens) (aka interleukin 36 beta)
E: cxcl8 (homo sapiens) (aka c-x-c motif chemokine ligand 8)
F: None of the above. | E |
<Instruct>: Given the context 'Here we show that mice deficient in the chemoattractant C5a receptor, in comparison to their wild-type littermates, were unable to clear intrapulmonary-instilled Pseudomonas aeruginosa, despite a marked increase in neutrophil influx, and succumbed to pneumonia.', select the correct biomedical concept corresponding to 'c5a receptor'. Answer using one of the provided options. | <Options>: A: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
B: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
C: c5ar (homo sapiens) (aka complement c5a receptor 1)
D: c5ar (mus musculus) (aka complement component 5a receptor 1)
E: c5ar1 (bos taurus) (aka complement c5a receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'These C5a-receptor-deficient mice challenged with sublethal inocula of Pseudomonas become superinfected with secondary bacterial strains.', select the correct biomedical concept corresponding to 'c5a-receptor'. Answer using one of the provided options. | <Options>: A: c5ar (homo sapiens) (aka complement c5a receptor 1)
B: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
C: c5ar (mus musculus) (aka complement component 5a receptor 1)
D: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
E: complement c5a receptor 1 (bos taurus) (aka complement c5a receptor 1)
F: None of the above. | A |
<Instruct>: Given the context 'We conclude that the C5a receptor has a non-redundant function, and is required for mucosal host defence in the lung.', select the correct biomedical concept corresponding to 'c5a receptor'. Answer using one of the provided options. | <Options>: A: c5ar1 (bos taurus) (aka complement c5a receptor 1)
B: complement c5a receptor 2 (homo sapiens) (aka complement c5a receptor 2)
C: complement c5a receptor 1 (homo sapiens) (aka complement c5a receptor 1)
D: c5ar1 (sus scrofa) (aka complement c5a receptor 1)
E: c5ar (mus musculus) (aka complement component 5a receptor 1)
F: None of the above. | C |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: lerk7 (homo sapiens) (aka ephrin a5)
C: lerk2 (homo sapiens) (aka ephrin b1)
D: lerk-4 (homo sapiens) (aka ephrin a4)
E: lerk-6 (homo sapiens) (aka ephrin a2)
F: None of the above. | C |
<Instruct>: Given the context 'Cell-cell adhesion mediated by binding of membrane-anchored ligand LERK-2 to the EPH-related receptor human embryonal kinase 2 promotes tyrosine kinase activity.
', select the correct biomedical concept corresponding to 'eph-related receptor human embryonal kinase 2'. Answer using one of the provided options. | <Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6)
B: eph receptor a2 (homo sapiens) (aka eph receptor a2)
C: eph receptor b2 (homo sapiens) (aka eph receptor b2)
D: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
E: etk2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept corresponding to 'embryonal kinase 2'. Answer using one of the provided options. | <Options>: A: etk-2 (mus musculus) (aka tyro3 protein tyrosine kinase 3)
B: etnk2 (homo sapiens) (aka ethanolamine kinase 2)
C: ek2 (danio rerio) (aka eph receptor a4a)
D: etk2 (homo sapiens) (aka eph receptor b3)
E: erb-b2 receptor tyrosine kinase 2 (gallus gallus) (aka erb-b2 receptor tyrosine kinase 2)
F: None of the above. | D |
<Instruct>: Given the context 'Human embryonal kinase 2 (HEK2) is a protein-tyrosine kinase that is a member of the EPH family of receptors.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6)
B: ephb2 (homo sapiens) (aka eph receptor b2)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: hek (homo sapiens) (aka eph receptor a3)
E: ek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
<Instruct>: Given the context 'Transcripts for HEK2 have a wide tissue distribution.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek7 (homo sapiens) (aka eph receptor a5)
B: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: ehk-2 (homo sapiens) (aka eph receptor a6)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: ek2 (homo sapiens) (aka eph receptor b3)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: None of the above. | D |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek (homo sapiens) (aka eph receptor a3)
B: ephb2 (homo sapiens) (aka eph receptor b2)
C: epht2 (homo sapiens) (aka eph receptor b1)
D: hek3 (homo sapiens) (aka eph receptor a8)
E: ehk-2 (homo sapiens) (aka eph receptor a6)
F: None of the above. | F |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek2 (homo sapiens) (aka eph receptor b3)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: ephb2 (homo sapiens) (aka eph receptor b2)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | A |
<Instruct>: Given the context 'In order to analyze functional effects between the LERKs and the HEK2 receptor, we expressed HEK2 cDNA in an interleukin-3-dependent progenitor cell line 32D that grows as single cells in culture.', select the correct biomedical concept corresponding to 'interleukin-3'. Answer using one of the provided options. | <Options>: A: interleukin 2 (homo sapiens) (aka interleukin 2)
B: il5 (homo sapiens) (aka interleukin 5)
C: interleukin 7 (homo sapiens) (aka interleukin 7)
D: interleukin 3 (homo sapiens) (aka interleukin 3)
E: csf3 (homo sapiens) (aka colony stimulating factor 3)
F: None of the above. | D |
<Instruct>: Given the context 'Within the group of LERKs, LERK-2 and -5 were shown to bind to HEK2.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ehk-2 (homo sapiens) (aka eph receptor a6)
B: hek7 (homo sapiens) (aka eph receptor a5)
C: hek2 (homo sapiens) (aka eph receptor b3)
D: ephb2 (homo sapiens) (aka eph receptor b2)
E: epht2 (homo sapiens) (aka eph receptor b1)
F: None of the above. | C |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk4 (homo sapiens) (aka ephrin a4)
B: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: lerk-1 (homo sapiens) (aka ephrin a1)
E: lerk2 (homo sapiens) (aka ephrin b1)
F: None of the above. | E |
<Instruct>: Given the context 'Membrane-bound and soluble forms of LERK-2 were demonstrated to signal through HEK2 as judged by receptor phosphorylation.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek3 (homo sapiens) (aka eph receptor a8)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: ek2 (homo sapiens) (aka eph receptor b3)
D: hek (homo sapiens) (aka eph receptor a3)
E: ephb2 (homo sapiens) (aka eph receptor b2)
F: None of the above. | C |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: hek2 (homo sapiens) (aka eph receptor b3)
B: epht2 (homo sapiens) (aka eph receptor b1)
C: hek (homo sapiens) (aka eph receptor a3)
D: eph receptor b2 (homo sapiens) (aka eph receptor b2)
E: hek3 (homo sapiens) (aka eph receptor a8)
F: None of the above. | A |
<Instruct>: Given the context 'Coincubation of HEK2 and LERK-2 expressing cells induced cell-cell adhesion and formation of cell aggregates.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk2 (homo sapiens) (aka ephrin b1)
B: lerk4 (homo sapiens) (aka ephrin a4)
C: lerk-1 (homo sapiens) (aka ephrin a1)
D: ephrin-b2 (homo sapiens) (aka ephrin b2)
E: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
F: None of the above. | A |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: etk-2 (homo sapiens) (aka tyro3 protein tyrosine kinase)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: hek7 (homo sapiens) (aka eph receptor a5)
D: hek (homo sapiens) (aka eph receptor a3)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
<Instruct>: Given the context 'This interaction could be inhibited by preincubation of HEK2 expressing cells with soluble LERK-2.', select the correct biomedical concept corresponding to 'lerk-2'. Answer using one of the provided options. | <Options>: A: lerk-2 (xenopus laevis) (aka ephrin-b1 l homeolog)
B: lerk-4 (homo sapiens) (aka ephrin a4)
C: lerk-6 (homo sapiens) (aka ephrin a2)
D: lerk5 (homo sapiens) (aka ephrin b2)
E: lerk2 (homo sapiens) (aka ephrin b1)
F: None of the above. | E |
<Instruct>: Given the context 'Coexpression of HEK2 and LERK-2 in 32D cells showed reduced kinase activity and autophosphorylation of HEK2 compared with the juxtacrine stimulation, which seems to be due to a reduced sensitivity of the receptor.', select the correct biomedical concept corresponding to 'hek2'. Answer using one of the provided options. | <Options>: A: ephb2 (homo sapiens) (aka eph receptor b2)
B: ehk-2 (homo sapiens) (aka eph receptor a6)
C: hek (homo sapiens) (aka eph receptor a3)
D: hek7 (homo sapiens) (aka eph receptor a5)
E: hek2 (homo sapiens) (aka eph receptor b3)
F: None of the above. | E |
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