instruction stringlengths 161 2.29k | input stringlengths 80 650 | response stringclasses 6 values |
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<Instruct>: Given the context 'Figure 1: A schematic diagram of the human X chromosome alongside the approximate cytogenetic location of fragments identified in nine irradiation hybrids (numbers across the top).', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: human (aka homo sapiens)
B: species
C: biota (aka cellular organisms)
D: humans (aka homo)
E: placental mammals (aka eutheria)
F: None of the above. | A |
<Instruct>: Given the context 'The human X fragments were identified by hybridization of 27 known DNA markers (indicated by a black line; P.N.G, unpublished) or by cosmids in common with unique X chromosome probes in the reference library database (open boxes and Table 1).', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: genus
B: birds (aka aves)
C: homo sapiens (human) (aka homo sapiens)
D: biota (aka cellular organisms)
E: this
F: None of the above. | C |
<Instruct>: Given the context 'denatured and sheared total human DNA in 50% formamide, 4XSSC, 0.05 M sodium phosphate pH 7.2, 0.001 M EDTA, 10% dextran sulphate, 1.0% SDS, 50 isg/ml denatured salmon sperm DNA and OxDenhardt's solution.', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: genus
B: cellular organisms (biota) (aka cellular organisms)
C: eutherian mammals (aka eutheria)
D: homo sapiens (human) (aka homo sapiens)
E: homo (humans) (aka homo)
F: None of the above. | D |
<Instruct>: Given the context 'The radioactively labelled Alu-PCR products were denatured and added to fresh
hybridization solution without human DNA competitor at 1 x 106
cpm/ml and hybridized at 42?C for 16 hours.', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: human (aka homo sapiens)
B: this
C: animals (aka metazoa)
D: genus
E: humans (aka homo)
F: None of the above. | A |
<Instruct>: Given the context 'The radioactively labelled Alu-PCR products were denatured and added to fresh
hybridization solution without human DNA competitor at 1 x 106
cpm/ml and hybridized at 42?C for 16 hours.', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: eutherian mammals (aka eutheria)
B: probles
C: suborder
D: species
E: genus
F: None of the above. | F |
<Instruct>: Given the context 'For each hybridization, two sets of duplicate cosmid filters were used from the ICRF reference library system (8), each containing 9216 flow-sorted human X chromosome cosmid clones or approximately 2 chromosome equivalents on a 22 x 22 cm filter (9).', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: biota (aka cellular organisms)
B: animals (aka metazoa)
C: mammals (aka mammalia)
D: probles
E: homo sapiens (human) (aka homo sapiens)
F: None of the above. | E |
<Instruct>: Given the context 'RESULTS
A panel of 195 X chromosome irradiation hybrids was constructed (50,000 rads) and characterized by DNA hybridization using 27 X chromosome markers and flourescence in situ hybridization using total human DNA as probe (Benham et al., 1989; P.N.G., unpublished).', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: species
B: mammals (aka mammalia)
C: homo (humans) (aka homo)
D: animals (aka metazoa)
E: homo sapiens (human) (aka homo sapiens)
F: None of the above. | E |
<Instruct>: Given the context 'All nine hybrids were used in PCR reactions with 3'-Alu primer 3144 and two were used with 5'-Alu
Figure 3: Hybridization of Alu-PCR products generated with Alu primer 3144 from irradiation hybrid 54 to a filter containing 420 YAC clones from the human X chromosome.', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: human (aka homo sapiens)
B: species
C: animals (aka metazoa)
D: eutherian mammals (aka eutheria)
E: humans (aka homo)
F: None of the above. | A |
<Instruct>: Given the context 'Example hybridizations to a human X chromosome cosmid filter in Fig 2 shows the intensity and reliability of positive clones identified on duplicate filters with Alu-PCR products from the same irradiation hybrid (48) and the independence of clones identified with Alu-PCR products from a different hybrid (54).', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: mammals (aka mammalia)
B: kingdom
C: human (aka homo sapiens)
D: primate (aka primates)
E: genus
F: None of the above. | C |
<Instruct>: Given the context 'Fig 3 shows a single positive YAC clone after hybridization of Alu-PCR products from irradiation hybrid 54 to a filter containing about 420 YAC clones specific for the human X chromosome.
', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: probles
B: macrobiotus sapiens
C: humans (aka homo)
D: homo sapiens (human) (aka homo sapiens)
E: primate (aka primates)
F: None of the above. | D |
<Instruct>: Given the context 'Since only 27 probes from the X chromosome were used to initially characterize the hybrids and the length of individual human fragments in the irradiation hybrids is about 1000-5000 kb, many regions could have been undetected in the original analysis.', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: homo (humans) (aka homo)
B: animals (aka metazoa)
C: primate (aka primates)
D: human (aka homo sapiens)
E: cellular organisms (biota) (aka cellular organisms)
F: None of the above. | D |
<Instruct>: Given the context 'However, since the exact length of the human DNA fragments for each hybrid and the spacing of Alu-PCR products along the chromosome is not known, it is difficult to directly correlate the number of target cosmids to the DNA content of the hybrids.
', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: genus
B: avian (aka aves)
C: animals (aka metazoa)
D: human (aka homo sapiens)
E: cellular organisms (biota) (aka cellular organisms)
F: None of the above. | D |
<Instruct>: Given the context 'The dissection of a total genomic YAC library by this method may be more efficient than generating chromosome specific YAC libraries from somatic cell hybrids (usually a haploid human chromosome on a diploid or greater rodent background) or flow-sorted chromosomes, because of the low transformation efficiency of yeast.
', select the correct biomedical concept corresponding to 'human'. Answer using one of the provided options. | <Options>: A: mammals (aka mammalia)
B: macrobiotus sapiens
C: probles
D: birds (aka aves)
E: human (aka homo sapiens)
F: None of the above. | E |
<Instruct>: Given the context 'The dissection of a total genomic YAC library by this method may be more efficient than generating chromosome specific YAC libraries from somatic cell hybrids (usually a haploid human chromosome on a diploid or greater rodent background) or flow-sorted chromosomes, because of the low transformation efficiency of yeast.
', select the correct biomedical concept corresponding to 'yeast'. Answer using one of the provided options. | <Options>: A: saccharomyces sp.
B: saccharomyces cerevisiae (saccharomyces cerevisiae (desm.) meyen ex e.c. hansen, 1883) (aka saccharomyces cerevisiae)
C: saccharomyces lactis (aka kluyveromyces lactis)
D: saccharomycetes (hemiascomycetes) (aka saccharomycetes)
E: saccharomyces cerevisiae x saccharomyces mikatae
F: None of the above. | B |
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