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Hantavirus Pulmonary Syndrome: The Sound of a Mouse Roaring | |
Antimicrobial potential of macro and microalgae against pathogenic and spoilage microorganisms in food | Algae are a valuable and never-failing source of bioactive compounds. The increasing efforts to use ingredients that are as natural as possible in the formulation of innovative products has given rise to the introduction of macro and microalgae in food industry. To date, scarce information has been published about alga... |
Modelling input-output flows of severe acute respiratory syndrome in mainland China | BACKGROUND: Severe acute respiratory syndrome (SARS) originated in China in 2002, and it spread to 26 provinces in mainland China and 32 countries across five continents in a matter of months. This outbreak resulted in 774 deaths. However, the spatial features and potential determinants of SARS input-output flows remai... |
Lack of transparency during the COVID-19 pandemic: Nurturing a future and more devastating crisis | CoI: I am an unpaid member of the Haut Conseil de la Santé Publique (High Council of Public Health), the expert body of the Ministry of Health for the French government. |
Perceived Impact of Urologic Surgery Training Program Modifications due to COVID-19 in the United States | OBJECTIVE: Significant healthcare disruption due to pandemic coronavirus disease 2019 (COVID-19) has implications across all aspects of clinical care in the United States (US). In this study, we aim to assess urology residency program modifications in the context of COVID-19, and perceptions of the impact on urology tr... |
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus | Spike (S) proteins of coronaviruses, including the coronavirus that causes severe acute respiratory syndrome (SARS), associate with cellular receptors to mediate infection of their target cells(1,2). Here we identify a metallopeptidase, angiotensin-converting enzyme 2 (ACE2)(3,4), isolated from SARS coronavirus (SARS-C... |
Global Strategies for the Prevention and Control of Infectious Diseases and Non-Communicable Diseases | This article on global health reviews the environment surrounding health strategies and plans, as well as lessons learned from the first 15 years of the 21st century, followed by a discussion on the quest for a new paradigm for disease control efforts and challenges and opportunities for Japan. |
Correlation between dissociation and catalysis of SARS-CoV main protease | Abstract The dimeric interface of severe acute respiratory syndrome coronavirus main protease is a potential target for the anti-SARS drug development. We have generated C-terminal truncated mutants by serial truncations. The quaternary structure of the enzyme was analyzed using both sedimentation velocity and sediment... |
Crystal structure of Nsp15 endoribonuclease NendoU from SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS- and MERS-CoVs the detailed information about SARS-CoV-2 proteins structures and ... |
Polyglutamine Repeats in Viruses | This review explores the presence and functions of polyglutamine (polyQ) in viral proteins. In mammals, mutations in polyQ segments (and CAG repeats at the nucleotide level) have been linked to neural disorders and ataxias. PolyQ regions in normal human proteins have documented functional roles, in transcription factor... |
Minireview of progress in the structural study of SARS-CoV-2 proteins | Abstract A severe form of pneumonia, named coronavirus disease 2019 (COVID-19) by the World Health Organization, broke out in China and rapidly developed into a global pandemic, with millions of cases and hundreds of thousands of deaths reported globally. The novel coronavirus, which was designated as severe acute resp... |
Disidratazione acuta da gastroenterite nei lattanti | Il bambino sotto 1 anno e, soprattutto, di meno di 6 mesi è ad alto rischio di disidratazione, la cui causa principale è una gastroenterite acuta, soprattutto di origine virale. La gestione di una disidratazione da gastroenterite ha due componenti: la sua correzione e il rapido ripristino della normale perfusione tissu... |
Impact of dietary spray-dried bovine plasma addition on pigs infected with porcine epidemic diarrhea virus | Experimental data suggest that the addition of spray-dried plasma (SDP) to pig feed may enhance antibody responses against certain pathogens and negatively impact virus survival. The benefit of SDP on Escherichia coli infection is well documented. The aim of this study was to determine the effect of bovine SDP (BovSDP)... |
Super-spreaders and the rate of transmission of the SARS virus | Abstract We describe a stochastic small-world network model of transmission of the SARS virus. Unlike the standard Susceptible-Infected-Removed models of disease transmission, our model exhibits both geographically localised outbreaks and “super-spreaders”. Moreover, the combination of localised and long range links al... |
Community-acquired pneumonia in children — a changing spectrum of disease | Pneumonia remains the leading cause of death in children outside the neonatal period, despite advances in prevention and management. Over the last 20 years, there has been a substantial decrease in the incidence of childhood pneumonia and pneumonia-associated mortality. New conjugate vaccines against Haemophilus influe... |
Insulin Resistance in Osteoarthritis: Similar Mechanisms to Type 2 Diabetes Mellitus | Osteoarthritis (OA) and type 2 diabetes mellitus (T2D) are two of the most widespread chronic diseases. OA and T2D have common epidemiologic traits, are considered heterogenic multifactorial pathologies that develop through the interaction of genetic and environmental factors, and have common risk factors. In addition,... |
Virus respiratorios: viejos y nuevos virus. Revisión de métodos diagnósticos | Las infecciones respiratorias agudas de etiología viral se encuentran entre las principales causas de morbimortalidad infecciosa en el mundo. Junto a los virus tradicionalmente reconocidos, como los de la gripe, virus respiratorio sincitial, rinovirus, parainfluenza 1 a 4 y adenovirus, se han incorporado otros virus, c... |
Drug Repurposing to Fight Colistin and Carbapenem-Resistant Bacteria | The emergence of new resistance mechanisms, the failure of classical antibiotics in clinic, the decrease in the development of antibiotics in the industry are all challenges that lead us to consider new strategies for the treatment of infectious diseases. Indeed, in recent years controversy has intensified over strains... |
Ethique et recherche biomédicale durant l’épidémie du COVID-19 : ne confondons pas vitesse et précipitation ! | |
Convalescent plasma: A possible treatment protocol for COVID- 19 patients suffering from diabetes or underlying liver diseases | BACKGROUND & AIM: As on date, no specific treatment is available for devastating COVID-19 (SARS-CoV-2) infection. This pandemic viral infection has affected over 200 countries within a very short time and created a calamitous situationacross the globe. As per WHO guidelines, the treatment is mainly symptomatic andsuppo... |
Psychological status and fatigue of frontline staff two months after the COVID-19 pandemic outbreak in China: A cross-sectional study | OBJECTIVE: Assessing the psychological status and fatigue of frontline staff exposed to COVID-19 in China. MEASURES: A cross-sectional survey via online questionnaires was conducted to evaluate frontline staff's psychological status and fatigue. Occurrence of depression, anxiety, and fatigue were measured with the Pati... |
Healthcare Worker Perceptions of Mask Use during a Nosocomial Pertussis Outbreak—Pennsylvania, 2003 | Abstract BACKGROUND: Recent experiences with severe acute respiratory syndrome (SARS) and influenza have led to new Respiratory Hygiene and Cough Etiquette (RHCE) recommendations that include use of surgical masks by healthcare workers (HCWs) who come within 3 feet of all patients with symptoms of respiratory infection... |
A Review of Current Interventions for COVID-19 Prevention | Abstract The recent outbreak of CoVID-19 is declared as a global public health emergency of international concern by the World Health Organization (WHO). A fresh figure of 2268011 positive cases and 155185 death records (till April 18th 2020) across the worldwide signify the severity of this viral infection. CoVID-19 i... |
Late Recognition of SARS in Nosocomial Outbreak, Toronto | Late recognition of severe acute respiratory syndrome (SARS) was associated with no known SARS contact, hospitalization before the nosocomial outbreak was recognized, symptom onset while hospitalized, wards with SARS clusters, and postoperative status. SARS is difficult to recognize in hospitalized patients with a vari... |
Age is just a number – and so is frailty: Strategies to inform resource allocation during the COVID-19 pandemic | |
Mitochondrial Dynamics in Basal and Stressful Conditions | The historical role of mitochondria resides in converting the energy released during the oxidation of macromolecules (carbohydrates, lipids and proteins) into adenosine tri-phosphate, a major form of chemically stored energy which sustains cell growth and homeostasis. Beyond this role in bioenergetics regulation, mitoc... |
Anatomic evidence shows that lymphatic drainage exists in the pituitary to loop the cerebral lymphatic circulation | Respiratory infections can result in intracranial infections and unknown neurological symptoms. The central nervous system lacks classical meningeal lymphatic (circulation) drainage, and the exact underlying mechanisms of how immune cells from the peripheral lymphatic system enter the central nervous system (CNS) remai... |
Barriers to and new approaches for gene therapy and gene delivery in cystic fibrosis | Abstract Clinical trials of gene therapy for cystic fibrosis suggest that current levels of gene transfer efficiency are probably too low to result in clinical benefit, largely as a result of the barriers faced by gene transfer vectors within the airways. The respiratory epithelium has evolved a complex series of extra... |
Cynomolgus Macaque as an Animal Model for Severe Acute Respiratory Syndrome | BACKGROUND: The emergence of severe acute respiratory syndrome (SARS) in 2002 and 2003 affected global health and caused major economic disruption. Adequate animal models are required to study the underlying pathogenesis of SARS-associated coronavirus (SARS-CoV) infection and to develop effective vaccines and therapeut... |
Attenuated Measles Virus as a Vaccine Vector | Live attenuated measles virus (MV) vaccines have an impressive record of safety, efficacy and ability to induce life-long immunity against measles infection. Using reverse genetics technology, such negative-strand RNA viruses can now be rescued from cloned DNA. This technology allows the insertion of exogenous genes en... |
Air Travel and Respiratory Disease | |
Acute phase proteins as local biomarkers of respiratory infection in calves | BACKGROUND: Cumulating reports suggest that acute phase proteins (APPs) do not only play a role as systemic inflammatory mediators, but are also expressed in different tissues as local reaction to inflammatory stimuli. The present study aimed to evaluate presence and changes in luminal lung concentrations of the APPs h... |
Pan-cancer analysis of transmembrane protease serine 2 and cathepsin L that mediate cellular SARS-CoV-2 infection leading to COVID-19 | Severe acute respiratory syndrome (SARS) coronavirus-2 (SARS-CoV2) is the cause of a new disease (COVID-19) which has evolved into a pandemic during the first half of 2020. Older age, male sex and certain underlying diseases, including cancer, appear to significantly increase the risk for severe COVID-19. SARS-CoV-2 in... |
Wound Healing Center: Analysis of preventive measures and new indications in a teaching hospital in central Italy during the Covid‐19 emergency | |
Saturation of critical care capacity and mortality in patients with the novel coronavirus (COVID-19) in Italy | |
SARS-CoV2 envelope protein: Non-synonymous mutations and its consequences | Abstract In the NCBI database, as on June 6, 2020, total number of available complete genome sequences of SARS-CoV2 across the world is 3617. The envelope protein of SARS-CoV2 possesses several non-synonymous mutations over the transmembrane domain and (C)-terminus in 15 (0.414%) genomes among 3617 available SARS-CoV2 ... |
Assessing the Exacerbations Risk of Influenza‐Associated Chronic Occupational Asthma | The purpose of this article was to conduct a risk‐based study based on a linkage of experimental human influenza infections and fluctuation analysis of airway function to assess whether influenza viral infection was risk factor for exacerbations of chronic occupational asthma. Here we provided a comprehensive probabili... |
Forests in a warming world | Summary As the climate catastrophe unfolds, forests are an important part of nature’s carbon sequestration and storage and thus planet-wide damage limitation. But will they still be able to play that role in a warmer world? As some forest ecosystems already suffer from rising temperatures, a comprehensive study of fore... |
COVID-19 containment measures adopted by AIEOP centres to prevent the virus spread among healthcare providers | |
Emerging coronavirus diseases and future perspectives | Coronavirus related infectious diseases seems to be biggest challenge of 21 century that have been constantly emerging and threating public health around the globe. Coronavirus disease-19 (COVID-19) that was detected as cause of respiratory tract infection in China by end the December 2019 impelled World Health Organiz... |
Differential transcription of matrix-metalloproteinase genes in primary mouse astrocytes and microglia infected with Theiler’s murine encephalomyelitis virus | The BeAn strain of Theiler’s murine encephalomyelitis virus (TMEV) induces demyelinating disease in susceptible mice comparable to human multiple sclerosis. Recent in vivo studies showed that matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of MMPs, TIMPs) are associated with demyelination in Th... |
Spectrum of Viral Infections Among Primary Immunodeficient Children: Report From a National Registry | Objective: To present the frequency and spectrum of viral infections in primary immunodeficient children. Methods: The data was obtained from the Kuwait National Primary Immunodeficiency Disorders (PIDs) Registry during the period of 2004-2018. Results: A total of 274 PID children were registered in KNPIDR during the s... |
COVID‐19 Vulnerability Among People Who Use Drugs: Recommendations for Global Public Health Programs and Policies | As cases of COVID‐19, the disease caused by the novel coronavirus (SARS‐CoV‐2), continue to spread globally, public health experts have warned about the devastating impact this pandemic may have on society's most vulnerable(1). Meanwhile, another public health crisis, the opioid epidemic, rages on throughout the U.S. (... |
Use of Sensitive, Broad-Spectrum Molecular Assays and Human Airway Epithelium Cultures for Detection of Respiratory Pathogens | Rapid and accurate detection and identification of viruses causing respiratory tract infections is important for patient care and disease control. Despite the fact that several assays are available, identification of an etiological agent is not possible in ∼30% of patients suffering from respiratory tract diseases. The... |
Role of Pharmacists in COVID-19 Disease: A Jordanian Perspective | OBJECTIVES: The novel 2019 coronavirus outbreak that first appeared in Wuhan has quickly gained global attention, due to its high transmissibility and devastating clinical and economic outcomes. The aim of this study was to assess the possible roles of Jordanian pharmacists in minimizing the stage of community transmis... |
CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections | The protective roles of endosomal toll-like receptors (TLRs) and cytosolic nucleic acid sensors are well elucidated, but the pathogenic host factors during viral infections remain unclear. Spleen tyrosine kinase (Syk)-coupled C-type lectins (CLECs) CLEC2 and CLEC5A are highly expressed on platelets and myeloid cells, r... |
CRISPR-based surveillance for COVID-19 using genomically-comprehensive machine learning design | The emergence and outbreak of SARS-CoV-2, the causative agent of COVID-19, has rapidly become a global concern and has highlighted the need for fast, sensitive, and specific tools to surveil circulating viruses. Here we provide assay designs and experimental resources, for use with CRISPR-based nucleic acid detection, ... |
RNA regulatory processes in RNA virus biology | Numerous post‐transcriptional RNA processes play a major role in regulating the quantity, quality and diversity of gene expression in the cell. These include RNA processing events such as capping, splicing, polyadenylation and modification, but also aspects such as RNA localization, decay, translation, and non‐coding R... |
Identification of previously unknown antigenic epitopes on the S and N proteins of avian infectious bronchitis virus | This paper describes mapping of antigenic and host-protective epitopes of infectious bronchitis virus proteins by assessing the ability of defined peptide regions within the S1, S2 and N proteins to elicit humoral, cell-mediated and protective immune responses. Peptides corresponding to six regions in the S1 (Sp1–Sp6),... |
JAID/JSC Guidelines for the Treatment of Respiratory Infectious Diseases: The Japanese Association for Infectious Diseases/Japanese Society of Chemotherapy – The JAID/JSC Guide to Clinical Management of Infectious Disease/Guideline-preparing Committee Respiratory Infectious Disease WG | |
Cutaneous manifestations in hospitalized patients diagnosed as COVID‐19 | BACKGROUND: Cutaneous manifestations of COVID‐19 disease have not yet been fully described. OBJECTIVES: To describe cutaneous manifestations of COVID‐19 disease in hospitalized patients. METHODS: We examined the cutaneous manifestations of 210 hospitalized patients. RESULTS: Cutaneous findings were observed during COVI... |
Fluid colour sign on chest ultrasonography in a cat with exudate pleural effusion and pleuropneumonia | |
Traditional Chinese herbal medicine as a source of molecules with antiviral activity | Abstract Traditional Chinese herbal medicine (TCHM) is widely used in the prevention and treatment of viral infectious diseases. However, the operative mechanisms of TCHM remain largely obscure, mainly because of its complicated nature and the fragmented nature of research. In recent years, systematic methodologies hav... |
Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1 | Changes in influenza viruses require regular reformulation of strain-specific influenza vaccines. Vaccines based on conserved antigens provide broader protection. Influenza matrix protein 2 (M2) is highly conserved across influenza A subtypes. To evaluate its efficacy as a vaccine candidate, we vaccinated mice with M2 ... |
Inclusion of Oat in Feeding Can Increase the Potential Probiotic Bifidobacteria in Sow Milk | SIMPLE SUMMARY: In this study we isolated and characterized potential probiotic bifidobacteria from sow milk. The bifidobacterial population in milk has been attributed to the existence of prebiotic oat in feeding systems. Since breast feeding protects the newborns against several infectious diseases, milk from sows fe... |
Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production | Recent epidemiological data indicate that outbreaks of hand, foot, and mouth disease (HFMD), which can be categorized according to its clinical symptoms as typical or atypical, have markedly increased worldwide. A primary causative agent for typical HFMD outbreaks, enterovirus 71 (EV71), has been shown to manipulate th... |
COVID‐19: Consider IL6 receptor antagonist for the therapy of cytokine storm syndrome in SARS‐CoV‐2 infected patients | COVID‐19 leads to mortality of several patients and the cytokine storm is reportedly critical in the patients. In order to reduce the cytokine storm, we would like to propose the IL6 receptor antagonist therapy for the COVID‐19 patients. Two humanized monoclonal antibodies are in clinical trial following IL6R antagonis... |
Use of the human colorectal adenocarcinoma (Caco‐2) cell line for isolating respiratory viruses from nasopharyngeal aspirates | The human colorectal adenocarcinoma‐derived Caco‐2 cell line was evaluated as a means isolating common respiratory viruses from nasopharyngeal aspirates for the diagnosis of respiratory diseases. One hundred eighty‐nine direct immunofluorescence positive nasopharyngeal aspirates obtained from patients with various vira... |
Comparison of human metapneumovirus, respiratory syncytial virus and Rhinovirus respiratory tract infections in young children admitted to hospital | Respiratory Syncytial Virus (RSV), Human metapneumovirus (HMPV), and Rhinoviruses (RV) are frequent causes of respiratory tract infections in young children. We compared laboratory and clinical findings in children with comparable age distribution and hospitalized due to RSV, HMPV or RV infections. Viral pathogens were... |
Rational Vaccine Design in the Time of COVID-19 | As scientists consider SARS-CoV-2 vaccine design, we discuss problems that may be encountered and how to tackle them by what we term “rational vaccine design.” We further discuss approaches to pan-coronavirus vaccines. We draw on experiences from recent research on several viruses including HIV and influenza, as well a... |
Continuous intravenous anaesthesia with sufentanil and midazolam in medetomidine premedicated New Zealand White rabbits | BACKGROUND: Anaesthesia in rabbits is associated with a high mortality rate, compared to that in cats and dogs. Total intravenous anaesthesia (TIVA) with drugs that provide cardiovascular stability and are rapidly metabolised could be of benefit for use in rabbits. The aim was to evaluate cardiorespiratory effects of T... |
Laboratory Diagnosis of Four Recent Sporadic Cases of Community-acquired SARS, Guangdong Province, China | Four cases of severe acute respiratory syndrome (SARS) that occurred from December 16, 2003, to January 8, 2004, in the city of Guangzhou, Guangdong Province, China, were investigated. Clinical specimens collected from these patients were tested by provincial and national laboratories in China as well as members of the... |
Epithelial cell lines of the cotton rat (Sigmodon hispidus) are highly susceptible in vitro models to zoonotic Bunya-, Rhabdo-, and Flaviviruses | BACKGROUND: Small mammals such as bats and rodents have been increasingly recognized as reservoirs of novel potentially zoonotic pathogens. However, few in vitro model systems to date allow assessment of zoonotic viruses in a relevant host context. The cotton rat (Sigmodon hispidus) is a New World rodent species that h... |
To investigate the association between the health literacy and hand hygiene practices of the older adults to help them fight against infectious diseases in Hong Kong | BACKGROUND: Proper hand hygiene helps prevent infectious diseases, while health literacy plays a critical role in preventive health behaviors. It remains unclear as to why proper hand hygiene practices cannot be sustained and what role health literacy plays in older adults fight against infectious diseases. METHODS: A ... |
Geminivirus protein structure and function | Geminiviruses are a family of plant viruses that cause economically important plant diseases worldwide. These viruses have circular single‐stranded DNA genomes and four to eight genes that are expressed from both strands of the double‐stranded DNA replicative intermediate. The transcription of these genes occurs under ... |
Pseudotyped Vesicular Stomatitis Virus for Functional Analysis of Sars Coronavirus Spike Protein | |
Age, “Life-Cycles,” and the Allocation of Scarce Medical Resources∗ | |
Assessing spread risk of Wuhan novel coronavirus within and beyond China, January-April 2020: a travel network-based modelling study | BACKGROUND: A novel coronavirus (2019-nCoV) emerged in Wuhan City, China, at the end of 2019 and has caused an outbreak of human-to-human transmission with a Public Health Emergency of International Concern declared by the World Health Organization on January 30, 2020. AIM: We aimed to estimate the potential risk and g... |
Epidemiology of respiratory viruses in bronchoalveolar lavage samples in a tertiary hospital | Abstract Background The prevalence of respiratory viruses in adults is largely underexplored, as most studies focus on children. Additionally, in severely ill or immunocompromised adults, where respiratory infections are mostly attributed to bacteria and fungi; respiratory viruses can lead to severe complications. Obje... |
Beet yellows virus replicase and replicative compartments: parallels with other RNA viruses | In eukaryotic virus systems, infection leads to induction of membranous compartments in which replication occurs. Virus-encoded subunits of the replication complex mediate its interaction with membranes. As replication platforms, RNA viruses use the cytoplasmic surfaces of different membrane compartments, e.g., endopla... |
Efectos de la infección viral en el paciente trasplantado | Las infecciones virales continúan siendo una importante causa de morbimortalidad en los pacientes trasplantados. En estos pacientes, el riesgo de infección viral depende de varios factores como el tipo de trasplante, la intensidad de la inmunosupresión y la susceptibilidad del receptor. Además de efectos directos, la i... |
Synthesis and biological activity of new glycyrrhizic acid conjugates with amino acids and dipeptides | New glycyrrhizic acid (GA) conjugates were synthesized with the use of tert-butyl esters of amino acids or benzyl esters of dipeptides; they contained two residues of L-amino acids (Met, Phe, Pro, and Ile or dipeptides Gly-Leu and Gly-Phe). Activation of GA carboxy groups was carried out with the help of N-hydroxysucci... |
Microbial Cleaning for Removal of Surface Contamination | Microbial cleaning takes advantage of naturally occurring microbes to remove a wide variety of contaminants from various surfaces. The method is based on the affinity of microbes for hydrocarbons which are digested, producing harmless carbon dioxide, water and soluble fatty acids. The microbes are nonpathogenic and are... |
Structural comparison strengthens the higher-order classification of proteases related to chymotrypsin | Specific cleavage of proteins by proteases is essential for several cellular, physiological, and viral processes. Chymotrypsin-related proteases that form the PA clan in the MEROPS classification of proteases is one of the largest and most diverse group of proteases. The PA clan comprises serine proteases from bacteria... |
Neurotoxicosis in 4 Cats Receiving Ronidazole | |
Viral Evasion Strategies in Type I IFN Signaling – A Summary of Recent Developments | The immune system protects the organism against infections and the damage associated with them. The first line of defense against pathogens is the innate immune response. In the case of a viral infection, it induces the interferon (IFN) signaling cascade and eventually the expression of type I IFN, which then causes an... |
Pre-spillover Prevention of Emerging Zoonotic Diseases: What Are the Targets and What Are the Tools? | The uneven standards of surveillance, human- or animal-based, for zoonotic diseases or pathogens maintained and transmitted by wildlife H R s, or even domestic species, is a global problem, readily apparent even within the United States, where investment in public health, including surveillance systems, has a long and ... |
Clinical Features of Critical Coronavirus Disease 2019 in Children | We sought to describe the presentation, course, and outcomes of hospitalized pediatric coronavirus disease 2019 patients, with detailed description of those requiring mechanical ventilation, and comparisons between critically ill and noncritical hospitalized pediatric patients. DESIGN: Observational cohort study. SETTI... |
Health workers' safety during tracheostomy in COVID‐19 patients: Homemade protective screen | As an aerosol and droplets generating procedure, tracheostomy increases contamination risks for health workers in the coronavirus disease context. To preserve the health care system capacity and to limit virus cross‐transmission, protecting caregivers against coronavirus infection is of critical importance. We report t... |
A dual-centre observational review of hospital based palliative care in patients dying with COVID-19 | Abstract The current Covid-19 pandemic has put significant strain on all aspects of healthcare delivery, including palliative care services. Given the high mortality from this disease, particularly in the more vulnerable members of society, it is important to examine how best to deliver a high standard of end of life c... |
HVAC filtration for controlling infectious airborne disease transmission in indoor environments: Predicting risk reductions and operational costs | Abstract This work describes and applies a methodology for estimating the impact of recirculating heating, ventilating, and air-conditioning (HVAC) particle filters on the control of size-resolved infectious aerosols in indoor environments using a modified version of the Wells-Riley model for predicting risks of infect... |
MERS-CoV spillover at the camel-human interface | Middle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic virus originating in camels that has been causing significant mortality and morbidity in humans in the Arabian Peninsula. The epidemiology of the virus remains poorly understood, with hospital outbreaks, isolated cases with known exposure to camels a... |
The importance of a “socially responsible” approach during COVID-19: the invisible heroes of science in Italy | |
Expression profiling meta-analysis of ACE2 and TMPRSS2, the putative anti-inflammatory receptor and priming protease of SARS-CoV-2 in human cells, and identification of putative modulators | Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has resulted in hundreds of thousands of deaths worldwide. While the majority of people with COVID-19 won’t require hospitalization, those who do may experience severe life-threatening complications, includ... |
Severe Acute Respiratory Syndrome Epidemic in Asia | We analyzed the dynamics of cumulative severe acute respiratory syndrome (SARS) cases in Singapore, Hong Kong, and Beijing using the Richards model. The predicted total SARS incidence was close to the actual number of cases; the predicted cessation date was close to the lower limit of the 95% confidence interval. |
Diferencias en función de la edad y la autopercepción del envejecimiento en ansiedad, tristeza, soledad y sintomatología comórbida ansioso-depresiva durante el confinamiento por el COVID-19 | Resumen Objetivos: Analizar si existen diferencias en función de la edad en ansiedad, tristeza, soledad y comorbilidad ansioso-depresiva en personas jóvenes, de mediana edad y mayores confinadas debido a la pandemia del COVID-19, y explorar la relación entre la autopercepción negativa del envejecimiento y nivel de sint... |
Cellular response to influenza virus infection: a potential role for autophagy in CXCL10 and interferon-alpha induction | Historically, influenza pandemics have arisen from avian influenza viruses. Avian influenza viruses H5N1 and H9N2 are potential pandemic candidates. Infection of humans with the highly pathogenic avian influenza H5N1 virus is associated with a mortality in excess of 60%, which has been attributed to dysregulation of th... |
The protective role of microRNA-21 against coxsackievirus B3 infection through targeting the MAP2K3/P38 MAPK signaling pathway | BACKGROUND: The P38 mitogen-activated protein kinase (MAPK) pathway plays an essential role in CVB3-induced diseases. We previously demonstrated microRNA-21 has potential inhibitory effect on the MAP2K3 which locates upstream of P38 MAPK and was upregulated in mouse hearts upon CVB3 infection. However, the effect and u... |
Mask is the possible key for self‐isolation in COVID‐19 pandemic | Ma's research shows N95 masks, medical masks, even homemade masks could block at least 90% of the virus in aerosols(1). This study puts the debate on whether the public wear masks back on the table. Recently Science interviewed Dr. Gao, director‐general of Chinese Center for Disease Control and Prevention (CDC). This a... |
Inflection point: The future of subcontracting in the petroleum industry | Abstract Oil prices have been in the downtrend since the recession of 2008. Since then, companies have struggled to survive as factors of production are being driven by external influences. International efforts to create a sustainable environment further intricates the supply and demand curve as countries develop poli... |
Bureaucratic Accountability and Disaster Response: Why Did the Korea Coast Guard Fail in Its Rescue Mission During the Sewol Ferry Accident? | The Sewol ferry accident, occurring in the ocean in South Korea on April 16, 2014, resulted in the loss of 304 lives. Some argue that one of the primary reasons for such an excessive death toll was because the post‐disaster rescue operations led by the Korea Coast Guard (KCG) were neither timely nor efficient and effec... |
ACE/ACE2 Ratio: A Key Also in 2019 Coronavirus Disease (Covid-19)? | |
Estimation of COVID-19 prevalence in Italy, Spain, and France | Abstract At the end of December 2019, coronavirus disease 2019 (COVID-19) appeared in Wuhan city, China. As of April 15, 2020, >1.9 million COVID-19 cases were confirmed worldwide, including >120,000 deaths. There is an urgent need to monitor and predict COVID-19 prevalence to control this spread more effectively. Time... |
An anti-Gn glycoprotein antibody from a convalescent patient potently inhibits the infection of severe fever with thrombocytopenia syndrome virus | Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease localized to China, Japan, and Korea that is characterized by severe hemorrhage and a high fatality rate. Currently, no specific vaccine or treatment has been approved for this disease. To develop a therapeutic agent for SFTS, we isola... |
Alphavirus Nucleocapsid Packaging and Assembly | Alphavirus nucleocapsids are assembled in the cytoplasm of infected cells from 240 copies of the capsid protein and the approximately 11 kb positive strand genomic RNA. However, the challenge of how the capsid specifically selects its RNA package and assembles around it has remained an elusive one to solve. In this rev... |
Mucosal Immunogenicity of Genetically Modified Lactobacillus acidophilus Expressing an HIV-1 Epitope within the Surface Layer Protein | Surface layer proteins of probiotic lactobacilli are theoretically efficient epitope-displaying scaffolds for oral vaccine delivery due to their high expression levels and surface localization. In this study, we constructed genetically modified Lactobacillus acidophilus strains expressing the membrane proximal external... |
An iterative and automated computational pipeline for untargeted strain-level identification using MS/MS spectra from pathogenic samples | Untargeted accurate strain-level classification of a priori unidentified organisms using tandem mass spectrometry is a challenging task. Reference databases often lack taxonomic depth, limiting peptide assignments to the species level. However, the extension with detailed strain information increases runtime and decrea... |
North Carolina frees up $30 million for BH during COVID‐19 crisis | North Carolina's seven regional managed care agencies for behavioral health are receiving $30 million so they can keep a variety of programs running during the COVID‐19 crisis, Carolina Public Press reported March 31. The money, which an N.C. Department of Health and Human Services (DHHS) spokesperson said represented ... |
Managing the R0 of Covid‐19: mathematics fights back | Perhaps for the first time in history, a single statistical measure is now dictating the entirety of UK government policy. The ‘basic reproduction number’, R0 value for Covid‐19 is more directly determining economic and social policy than has ever the inflation rate, interest rate, or exchange rate. It is encouraging t... |
A Multi-Tier Fog Content Orchestrator Mechanism with Quality of Experience Support | Abstract Video-on-Demand (VoD) services create a demand for content orchestrator mechanisms to support Quality of Experience (QoE). Fog computing brings benefits for enhancing the QoE for VoD services by caching the content closer to the user in a multi-tier fog architecture, considering their available resources to im... |
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