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Enfermedad por Coronavirus 2019 (COVID-19) en América Latina: Papel de la atención primaria en la preparación y respuesta | |
Evaluation of a field-deployable reverse transcription-insulated isothermal PCR for rapid and sensitive on-site detection of Zika virus | BACKGROUND: The recent emergence of Zika virus (ZIKV) in Brazil and its precipitous expansion throughout the Americas has highlighted the urgent need for a rapid and reliable on-site diagnostic assay suitable for viral detection. Such point-of-need (PON), low-cost diagnostics are essential for ZIKV control in vulnerabl... |
Asthma | Asthma is the most common inflammatory disease of the lungs. The prevalence of asthma is increasing in many parts of the world that have adopted aspects of the Western lifestyle, and the disease poses a substantial global health and economic burden. Asthma involves both the large-conducting and the small-conducting air... |
Bicontinuous cubic phases in biological and artificial self-assembled systems | Nature has created innumerable life forms with miraculous hierarchical structures and morphologies that are optimized for different life events through evolution over billions of years. Bicontinuous cubic structures, which are often described by triply periodic minimal surfaces (TPMSs) and their constant mean curvature... |
Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense? | The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefens... |
The closterovirus-derived gene expression and RNA interference vectors as tools for research and plant biotechnology | Important progress in understanding replication, interactions with host plants, and evolution of closteroviruses enabled engineering of several vectors for gene expression and virus-induced gene silencing. Due to the broad host range of closteroviruses, these vectors expanded vector applicability to include important w... |
Community-acquired pneumonia in children | Community acquired pneumonia (CAP) is common in childhood. Viruses account for most cases of CAP during the first two years of life. After this period, bacteria such as Streptococcus pneumoniae, Mycoplasma pneumoniae and Chlamydia pneumoniae become more frequent. CAP symptoms are nonspecific in younger infants, but cou... |
Incidence and Determinants of QT Interval Prolongation in COVID‐19 Patients Treated with Hydroxychloroquine and Azithromycin | Combined use of hydroxychloroquine and azithromycin was globally adopted, in part due to paucity and high cost of alternative therapies. However the utility of these medications has been questioned; and thus safety becomes a major concern given clinical equipoise regarding efficacy. This article is protected by copyrig... |
Review of the Lithuanian Alcohol Control Legislation in 1990–2020 | Since the early 1990s, Lithuania has experienced an increasing level of alcohol consumption and a heavy burden of alcohol-related harm, which is associated with the development of alcohol policies. The aim of this analysis was to provide a chronology of change of Lithuanian alcohol control legislation and to present se... |
Detection and Characterization of Distinct Alphacoronaviruses in Five Different Bat Species in Denmark | Bat populations harbour a multitude of viruses; some of these are pathogenic or potentially pathogenic in other animals or humans. Therefore, it is important to monitor the populations and characterize these viruses. In this study, the presence of coronaviruses (CoVs) in different species of Danish bats was investigate... |
From White Count to White Out | We present a 6-month-old boy with failure to thrive who was referred to the emergency department by his primary care doctor for leukocytosis and was found to be hypoxic with diffuse infiltrates on chest radiograph. Our patient was admitted and eventually diagnosed with Pneumocystis jirovecii pneumonia secondary to hype... |
Preparation of novel (Z)-4-ylidenebenzo[b]furo[3,2-d][1,3]oxazines and their biological activity() | A reaction of 2-acetyl-3-acylaminobenzo[b]furans (9d–o) with Vilsmeier (VM) reagent afforded a mixture of (E)- and (Z)-{(E)-2-aralkenylbenzo[b]furo[3,2-d][1,3]oxazin-4-ylidene}acetaldehydes (5) with a characteristic exo-formylmethylene group on the oxazine ring. The Z-isomer was more stable than the E-isomer. The Z-iso... |
PI3K-Akt-mTOR axis sustains rotavirus infection via the 4E-BP1 mediated autophagy pathway and represents an antiviral target | Rotavirus infection is a major cause of severe dehydrating diarrhea in infants younger than 5 y old and in particular cases of immunocompromised patients irrespective to the age of the patients. Although vaccines have been developed, antiviral therapy is an important complement that cannot be substituted. Because of th... |
Impact of COVID-19 on the Practice of Clinical Radiology | We examine the impact of COVID-19 on the future of Radiology in the following domains: employment/compensation/practice; location and hours of work; workplace environment and safety; activities beyond the “usual scope” of practice; and CME/meetings/professional organizations. |
COVID-19: Don't Neglect the Gastrointestinal Tract! | n/a. |
Chapter 5 Common Myths and Legends of Rabies | Abstract Humankind has somewhat of a dark, yet almost fascinating, supernatural relationship with rabies. Even after Pasteur's rabies vaccine discovery, globally people continue to be stricken with it today. History has carried along the myths and legends that surround this diabolical virus. Some still believe that rab... |
Neuroimaging findings in COVID-19 and other coronavirus infections: a systematic review in 116 patients | Abstract Various neurologic syndromes have been described in patients with COVID-19 and other coronavirus infections. In this paper, we systematically reviewed the available imaging findings of patients diagnosed with neurological symptoms associated with coronavirus infections. Diverse radiologic results in the contex... |
Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong | The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak studies have revealed the possible airborne route. To develop more speci... |
Elective tracheostomy during COVID-19 outbreak: to whom, when, how? Early experience from Venice, Italy | PURPOSE: The need for prolonged invasive mechanical ventilation in COVID-19 patients is placing the otorhinolaryngologist in front of an increasing request for tracheostomy. Nowadays, there is uncertainty regarding the timing of tracheostomy, the prognosis of these patients and the safety of healthcare workers. The aim... |
Decontamination of rooms, medical equipment and ambulances using an aerosol of hydrogen peroxide disinfectant | Summary A programmable device (Sterinis, Gloster Sante Europe) providing a dry fume of 5% hydrogen peroxide (H2O2) disinfectant was tested for decontamination of rooms, ambulances and different types of medical equipment. Pre-set concentrations were used according to the volumes of the rooms and garages. Three cycles w... |
A Comment on “Quaternary Prevention in Public Health” by Dr. Jong-Myon Bae | |
Pericollapse Stage of Osteonecrosis of the Femoral Head: A Last Chance for Joint Preservation | OBJECTIVE: To propose a new definition of the pericollapse stage of osteonecrosis of the femoral head (ONFH) and review its significance in disease diagnosis and treatment selection. DATA SOURCES: A search for eligible studies was conducted in three electronic databases including PubMed, Cochrane Library, and Embase up... |
The Use of Respirators to Reduce Inhalation of Airborne Biological Agents | |
Positive strand RNA virus replication: It depends on the ends | |
Role and mechanism of angiotensin-converting enzyme 2 in acute lung injury in coronavirus disease 2019 | Coronavirus disease 2019 is a major threat to public health globally. Though its pathogenesis has not been fully elucidated, angiotensin-converting enzyme 2 (ACE2) has been recently identified as a receptor for the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the cell. Here, we aimed to cl... |
HCMV glycoprotein B subunit vaccine efficacy was mediated by non-neutralizing antibody effector functions | Human cytomegalovirus (HCMV) is the most common congenital infection worldwide, frequently causing hearing loss and brain damage in afflicted infants. A vaccine to prevent maternal acquisition of HCMV during pregnancy is necessary to reduce the incidence of infant disease. The glycoprotein B (gB) + MF59 adjuvant subuni... |
Challenges in maintaining treatment services for people who use drugs during the COVID-19 pandemic | The impact of COVID-19 across health services, including treatment services for people who use drugs, is emerging but likely to have a high impact. Treatment services for people who use drugs provide essential treatment services including opiate agonist treatment and needle syringe programmes alongside other important ... |
Nonstructural protein 9 residues 586 and 592 are critical sites in determining the replication efficiency and fatal virulence of the Chinese highly pathogenic porcine reproductive and respiratory syndrome virus | Abstract The highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) has caused huge economic losses to the swine industry in China. Understanding the molecular basis in relation to the virulence of HP-PRRSV is essential for effectively controlling clinical infection and disease. In the current... |
Application of a Real-Time Polymerase Chain Reaction with Internal Positive Control for Detection and Quantification of Enterovirus in Cerebrospinal Fluid | A quantitative real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method based on TaqMan technology was developed to determine the presence and amount of enterovirus RNA. In order to prevent false-negative results, a one-step multiplex RT-PCR was optimized. It contains two dual-labelled fluorogenic prob... |
Isolation is not the answer | International scientific collaboration is the best defence against bioterror. |
Effect of preweaning feeding of pasteurized and nonpasteurized milk on postweaning weight gain of heifer calves on a Californian dairy | Abstract The effect of preweaning feeding of pasteurized colostrum and pasteurized waste milk on postweaning performance of dairy heifers on a dairy in the Central Valley of California was investigated as an extension of a clinical trial examining the effect of preweaning growth and morbidity on performance at weaning.... |
Personalized recovery of severe COVID19: Rehabilitation from the perspective of patient needs | After long term hospitalization or ICU treatment, COVID‐19 patients are severe functionally impaired. They experience not only physical weakness but may also suffer from problems on the pulmonary, physical, psychosocial and cognitive domain. These domains interact and the impact on participation varies between patients... |
Bats Without Borders: Long-Distance Movements and Implications for Disease Risk Management | Fruit bats of the genus Pteropus (commonly known as flying-foxes) are the natural hosts of several recently emerged zoonotic viruses of animal and human health significance in Australia and Asia, including Hendra and Nipah viruses. Satellite telemetry was used on nine flying-foxes of three species (Pteropus alecto n = ... |
Quantification and determinants of the amount of respiratory syncytial virus (RSV) shed using real time PCR data from a longitudinal household study | Background: A better understanding of respiratory syncytial virus (RSV) epidemiology requires realistic estimates of RSV shedding patterns, quantities shed, and identification of the related underlying factors. Methods: RSV infection data arise from a cohort study of 47 households with 493 occupants, in coastal Kenya, ... |
Plasmacytoid dendritic cells: one-trick ponies or workhorses of the immune system? | Plasmacytoid dendritic cells (pDCs) were first described as interferon-producing cells and, for many years, their overlapping characteristics with both lymphocytes and classical dendritic cells (cDCs) created confusion over their exact ontogeny. In this Viewpoint article, Nature Reviews Immunology asks five leaders in ... |
Prevention of fogging of protective eyewear for medical staff during the COVID-19 pandemic | |
No observed effect of homologous recombination on influenza C virus evolution | The occurrence of homologous recombination in influenza viruses has been under some debate recently. To determine the extent of homologous recombination in influenza C virus, recombination analyses of all available gene sequences of influenza C virus were carried out. No recombination signal was found. With the previou... |
One Health: Past Successes and Future Challenges in Three African Contexts | BACKGROUND: The recent emergence of zoonotic diseases such as Highly Pathogenic Avian Influenza (HPAI) and Severe Acute Respiratory Syndrome (SARS) have contributed to dominant Global Health narratives around health securitisation and pandemic preparedness, calling for greater co-operation between the health, veterinar... |
Make Data Sharing Routine to Prepare for Public Health Emergencies | Jean-Paul Chretien and colleagues argue that recent Ebola and Zika virus outbreaks highlight the importance of data sharing in scientific research. |
Coronavirus Disease 2019: Harnessing Healthy Fear via Knowledge, Attitudes, and Behavior | |
Infection prevention and chronic disease management in cystic fibrosis and noncystic fibrosis bronchiectasis | Bronchiectasis is a chronic lung disease (CLD) characterized by irreversible bronchial dilatation noted on computed tomography associated with chronic cough, ongoing viscid sputum production, and recurrent pulmonary infections. Patients with bronchiectasis can be classified into two groups: those with cystic fibrosis a... |
The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding | Many pathogens take advantage of the dependence of the host on the interaction of hundreds of extracellular proteins with the glycosaminoglycans heparan sulfate to regulate homeostasis and use heparan sulfate as a means to adhere and gain access to cells. Moreover, mucosal epithelia such as that of the respiratory trac... |
The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular Tropism | The spike (S) glycoprotein of the avian gammacoronavirus infectious bronchitis virus (IBV) is comprised of two subunits (S1 and S2), has a role in virulence in vivo, and is responsible for cellular tropism in vitro. We have previously demonstrated that replacement of the S glycoprotein ectodomain from the avirulent Bea... |
Changing risk awareness and personal protection measures for low to high pathogenic avian influenza in live-poultry markets in Taiwan, 2007 to 2012 | BACKGROUND: Outbreaks of low and high pathogenic avian influenza (LPAI, HPAI) H5N2 in chickens have occurred in Taiwan since 2003 and 2012, respectively. Fully understanding the different awareness, attitudes and protective behaviors adopted by workers in live-poultry markets (LPMWs) and local community residents (CRs)... |
Immunogenicity of a polyvalent HIV-1 candidate vaccine based on fourteen wild type gp120 proteins in golden hamsters | BACKGROUND: One of the major obstacles in the design of an effective vaccine against HIV-1 is the hypervariability of the HIV-1 envelope glycoprotein. Most HIV-1 vaccine candidates have utilized envelope glycoprotein from a single virus isolate, but to date, none of them elicited broadly reactive humoral immunity. Here... |
Stability issues of RT‐PCR testing of SARS‐CoV‐2 for hospitalized patients clinically diagnosed with COVID‐19 | In this study, we collected a total of 610 hospitalized patients from Wuhan between February 2, 2020, and February 17, 2020. We reported a potentially high false negative rate of real‐time reverse‐transcriptase polymerase chain reaction (RT‐PCR) testing for SARS‐CoV‐2 in the 610 hospitalized patients clinically diagnos... |
Modeling Control Strategies of Respiratory Pathogens | Effectively controlling infectious diseases requires quantitative comparisons of quarantine, infection control precautions, case identification and isolation, and immunization interventions. We used contact network epidemiology to predict the effect of various control policies for a mildly contagious disease, such as s... |
Human coronavirus NL63, a new respiratory virus | From the mid-1960s onwards, it was believed that only two human coronavirus species infect humans: HCoV-229E and HCoV-OC43. Then, in 2003, a novel member of the coronavirus family was introduced into the human population: SARS-CoV, causing an aggressive lung disease. Fortunately, this virus was soon expelled from the h... |
COVID‐19 in elderly kidney transplant recipients | The SARS‐Cov‐2 infection disease (COVID‐19) pandemic has posed at risk the kidney transplant (KT) population, particularly the elderly recipients. From March‐12(th) until April‐4(th) 2020, we diagnosed COVID‐19 in 16 of our 324 KT patients aged ≥65 years old (4.9%). Many of them had had contact with healthcare faciliti... |
Chapter 27 Personalized Medicine of Alzheimer’s Disease | Abstract Alzheimer’s disease (AD) is a major problem of health and disability, with a relevant economic impact on society (e.g., €177 billion in Europe). Despite important advances in pathogenesis, diagnosis, and treatment, The primary causes of AD remain elusive, accurate biomarkers are not well characterized, and ava... |
The common cold | Summary Despite great advances in medicine, the common cold continues to be a great burden on society in terms of human suffering and economic losses. Of the several viruses that cause the disease, the role of rhinoviruses is most prominent. About a quarter of all colds are still without proven cause, and the recent di... |
Using a CO(2) detector to confirm endotracheal intubation in SARS patients | |
Rapid detection of the Streptococcus mutans cnm gene by loop-mediated isothermal amplification | This study investigated a method using loop-mediated isothermal amplification (LAMP) for the rapid detection of cnm-positive Streptococcus mutans (S. mutans) associated with cerebral microhemorrhage. LAMP amplified the cnm gene plasmid vector, but not human or microbial genomic DNA. The cnm DNA of the cnm-positive S. m... |
The COVID‐19 outbreak and rheumatologic skin diseases | |
Efficacy, safety and cost‐effectiveness of hydroxychloroquine in children with COVID‐19: A call for evidence | The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic poses a serious threat to public health and local economies around the globe. This has created an urgent need to identify effective medications for its prevention and treatment (1). Among these treatments, the off-label use of hydroxychloro... |
Type I Interferon Regulates the Expression of Long Non-Coding RNAs | Interferons (IFNs) are key players in the antiviral response. IFN sensing by the cell activates transcription of IFN-stimulated genes (ISGs) able to induce an antiviral state by affecting viral replication and release. IFN also induces the expression of ISGs that function as negative regulators to limit the strength an... |
Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial | Summary Background No specific antiviral drug has been proven effective for treatment of patients with severe coronavirus disease 2019 (COVID-19). Remdesivir (GS-5734), a nucleoside analogue prodrug, has inhibitory effects on pathogenic animal and human coronaviruses, including severe acute respiratory syndrome coronav... |
Infection and the etiology and pathogenesis of multiple sclerosis | Multiple sclerosis (MS) currently defies clinical and scientific definitions, and carries a prognosis that remains practically unchanged despite many years of intensive research. Although the prevailing dogma is that MS is an immune-mediated condition, it fulfills none of the criteria of an autoimmune disease. On the o... |
Ten years’ experience with year-round active surveillance of up to 19 respiratory pathogens in children | INTRODUCTION: Surveillance systems for acute respiratory infections (ARI) in children currently are often limited in terms of the panel of pathogens and the age range investigated or are only syndromic and at times only active in the winter season. METHODS: Within PID-ARI.net, a research network for ARI in children in ... |
Assessing the spreading potential of an undetected case of COVID-19 in orthopaedic surgery | BACKGROUND: With the novel coronavirus-induced disease (COVID-19), there is the fear of nosocomial infections and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmissions to healthcare workers (HCW). We report the case of a 64-year-old male patient who underwent explantation of a shoulder prosthesis d... |
Global Reach of an Online COVID-19 Course in Multiple Languages on OpenWHO in the First Quarter of 2020: Analysis of Platform Use Data | BACKGROUND: At the onset of the coronavirus outbreak, the World Health Organization’s (WHO) Health Emergencies Learning and Capacity Development Unit, together with the WHO’s health technical lead on coronaviruses, developed a massive open online course within 3 weeks as part of the global response to the emergency. Th... |
Virology of infantile chronic recurrent parotitis in Santiago de Chile | Infantile chronic recurrent parotitis (ICRP) has been attributed to multiple causes, including viral infections, and therefore its treatment remains empirical. Our aim was to evaluate the involvement of respiratory and oropharyngeal viruses in acute episodes of ICRP. Seventy children were studied, 50 patients and 20 ag... |
ARIA‐EAACI statement on Asthma and COVID‐19 (June 2, 2020) | |
Urban‐Rural Polarisation in Times of the Corona Outbreak? The Early Demographic and Geographic Patterns of the SARS‐CoV‐2 Epidemic in the Netherlands | The global health crisis due to the pandemic of the SARS‐CoV‐2 is associated with processes of urbanisation and globalisation. Globally well‐connected areas with high population densities are hence expected to be disproportionately affected by COVID‐19. This paper investigates the role of population density within the ... |
ACE2 Gene Polymorphisms Do Not Affect Outcome of Severe Acute Respiratory Syndrome | |
Recommending wearing a mask without masking the truth | |
Etiology of community‐acquired pneumonia in 1500 hospitalized children | Childhood community‐acquired pneumonia (CAP) is a common illness; however, comprehensive studies of hospitalizations for CAP among children in China based on prospective and multicenter data collection are limited. The aim of this investigation was to determine the respiratory pathogens responsible for CAP in hospitali... |
Reactivation of COVID-19 pneumonia: a report of two cases | |
Children returning to schools following COVID-19: A balance of probabilities – Letter to the Editor | |
Procedures for Flow Cytometry‐Based Sorting of Unfixed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) Infected Cells and Other Infectious Agents | In response to the recent COVID‐19 pandemic, many laboratories are involved in research supporting SARS‐CoV‐2 vaccine development and clinical trials. Flow cytometry laboratories will be responsible for a large part of this effort by sorting unfixed antigen‐specific lymphocytes. Therefore, it is critical and timely tha... |
Rapid Field Immunoassay for Detecting Antibody to Sin Nombre Virus in Deer Mice | We developed a 1-hour field enzyme immunoassay (EIA) for detecting antibody to Sin Nombre virus in deer mice (Peromyscus maniculatus). The assay specificity and sensitivity were comparable to those of a standard EIA. This test will permit identification of rodents with antibody to this and perhaps other hantaviruses. |
Evaluation of Lassa antiviral compound ST-193 in a guinea pig model | Abstract Lassa virus (LASV), a member of the Arenaviridae family, causes a viral hemorrhagic fever endemic to West Africa, where as many as 300,000 infections occur per year. Presently, there are no FDA-approved LASV-specific vaccines or antiviral agents, although the antiviral drug ribavirin has shown some efficacy. A... |
Collection of Viable Aerosolized Influenza Virus and Other Respiratory Viruses in a Student Health Care Center through Water-Based Condensation Growth | The dynamics and significance of aerosol transmission of respiratory viruses are still controversial, for the major reasons that virus aerosols are inefficiently collected by commonly used air samplers and that the collected viruses are inactivated by the collection method. Without knowledge of virus viability, infecti... |
Simultaneous coinfection with Cryptococcus neoformans and Mycobacterium tuberculosis in an adult | |
A Hadoop-Based Platform for Patient Classification and Disease Diagnosis in Healthcare Applications | Nowadays, the increasing number of patients accompanied with the emergence of new symptoms and diseases makes heath monitoring and assessment a complicated task for medical staff and hospitals. Indeed, the processing of big and heterogeneous data collected by biomedical sensors along with the need of patients’ classifi... |
An AI approach to COVID-19 infection risk assessment in virtual visits: a case report | OBJECTIVE: In an effort to improve the efficiency of computer algorithms applied to screening for COVID-19 testing, we used natural language processing (NLP) and artificial intelligence (AI)-based methods with unstructured patient data collected through telehealth visits. METHODS: After segmenting and parsing documents... |
COVID‐19, leadership and lessons from physics | |
Infectious bronchitis virus regulates cellular stress granule signaling | Viruses must hijack cellular translation machinery to efficiently express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses swiftly relocate and repurpose translation machinery, resulting in global inhibition of translation and the aggregation of stalled 48S mRNPs into cyt... |
External quality assessment for the molecular detection of MERS-CoV in China | Abstract Background In May 2015, an imported case of Middle East respiratory syndrome coronavirus (MERS-CoV) infection occurred in China, so rapid and reliable diagnosis of suspected cases was necessary. Objectives An external quality assessment (EQA) program for the molecular detection of MERS-CoV was organized by the... |
Sustained Viremia and High Viral Load in Respiratory Tract Secretions Are Predictors for Death in Immunocompetent Adults with Adenovirus Pneumonia | The predictors for fatal adenovirus (AdV) pneumonia among immunocompetent adults are unclear. Laboratory-confirmed, hospitalized AdV pneumonia adults were prospectively enrolled in Beijing Chao-Yang hospital from March to June 2013. Clinical data and serial whole blood and respiratory tract secretions from such patient... |
Detection of astroviruses in feces of a cat with diarrhea | Astroviruses were detected by electron microscopy in the feces from a 4 month old kitten with diarrhea. The mean diameter of the viral particles was 28.7 nm, and they showed characteristic five- or six-pointed star-shaped surface configurations. The clinical disease manifested by the cat and the observed morphology of ... |
Transport and Management of Patients With Confirmed or Suspected Ebola Virus Disease | The foundation of safe care for patients with confirmed or suspected Ebola virus disease is effective infection control practice, which requires implementation of appropriate administrative policies, work practices, and environmental controls, accompanied by focused education, training, and supervision. In 2002, Emory ... |
COVID-19 - Journal de bord - 10/03/2020: Pandémie virale: s’inquiéter, organiser, prévoir | |
Immunology of Multiple Sclerosis | |
Chapter 501 Rubella Virus Non-Structural Protease | The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biol... |
COVID 19 can spread through breathing, talking, study estimates | Abstract The COVID 19 pandemic has become a major threat to humankind infecting millions world-wide. This virus can be spread through breathing, talking. During sneezing, breathing and loud conservation, it releases about 1000 micro droplets which drift in the air. These micro droplets carry many viruses and it might a... |
Short-term effects of weather parameters on COVID-19 morbidity in select US cities | Abstract Little is known about the environmental conditions that drive the spatiotemporal patterns of SARS-CoV-2, and preliminary research suggests an association with weather parameters. However, the relationship with temperature and humidity is not yet apparent for COVID-19 cases in US cities first impacted. The obje... |
SARS Patients and Need for Treatment | |
Bariatric surgery and the COVID-19 pandemic: SICOB recommendations on how to perform surgery during the outbreak and when to resume the activities in phase 2 of lockdown | The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its related disease, coronavirus disease 2019 (COVID-19), has been rapidly spreading all over the world and is responsible for the current pandemic. The current pandemic has found the Italian national health system unprepared to provide an appropriate... |
Reconstruction and prediction of viral disease epidemics | A growing number of infectious pathogens are spreading among geographic regions. Some pathogens that were previously not considered to pose a general threat to human health have emerged at regional and global scales, such as Zika and Ebola Virus Disease. Other pathogens, such as yellow fever virus, were previously thou... |
Effectiveness of Interventions to Reduce Contact Rates during a Simulated Influenza Pandemic | Measures to decrease contact between persons during an influenza pandemic have been included in pandemic response plans. We used stochastic simulation models to explore the effects of school closings, voluntary confinements of ill persons and their household contacts, and reductions in contacts among long-term care fac... |
Models of Eucalypt phenology predict bat population flux | Fruit bats (Pteropodidae) have received increased attention after the recent emergence of notable viral pathogens of bat origin. Their vagility hinders data collection on abundance and distribution, which constrains modeling efforts and our understanding of bat ecology, viral dynamics, and spillover. We addressed this ... |
Novel Compound Heterozygous DST Variants Causing Hereditary Sensory and Autonomic Neuropathies VI in Twins of a Chinese Family | Background: Hereditary sensory and autonomic neuropathies (HSANs) are a rare and severe group of sensory axonal neuropathies. HSANs have been classified into eight groups based on mode of inheritance, clinical features, and the involved genes. HSAN-VI, perhaps the most notable type, is an autosomal recessive disease, w... |
Severe atypical pneumonia in critically ill patients: a retrospective multicenter study | BACKGROUND: Chlamydophila pneumoniae (CP) and Mycoplasma pneumoniae (MP) patients could require intensive care unit (ICU) admission for acute respiratory failure. METHODS: Adults admitted between 2000 and 2015 to 20 French ICUs with proven atypical pneumonia were retrospectively described. Patients with MP were compare... |
SARS Outbreak, Taiwan, 2003 | We studied the severe acute respiratory syndrome (SARS) outbreak in Taiwan, using the daily case-reporting data from May 5 to June 4 to learn how it had spread so rapidly. Our results indicate that most SARS-infected persons had symptoms and were admitted before their infections were reclassified as probable cases. Thi... |
A review of the importance of cryptosporidiosis in farm animals | Abstract Cryptosporidium species are coccidian parasites with a large capacity to reproduce and to disseminate. Several species are known to infect farm animals, although the economic importance of cryptosporidiosis is highly host species dependent. This paper reviews the impact of cryptosporidial infections in livesto... |
CXCR2 Signaling Protects Oligodendrocytes and Restricts Demyelination in a Mouse Model of Viral-Induced Demyelination | BACKGROUND: The functional role of ELR-positive CXC chemokines during viral – induced demyelination was assessed. Inoculation of the neuroattenuated JHM strain of mouse hepatitis virus (JHMV) into the CNS of susceptible mice results in an acute encephalomyelitis that evolves into a chronic demyelinating disease, modeli... |
The RNA pseudoknots in foot-and-mouth disease virus are dispensable for genome replication but essential for the production of infectious virus | The positive stranded RNA genomes of picornaviruses comprise a single large open reading frame flanked by 5′ and 3′ untranslated regions (UTRs). Foot-and-mouth disease virus (FMDV) has an unusually large 5′ UTR (1.3 kb) containing five structural domains. These include the internal ribosome entry site (IRES), which fac... |
Digital prosthetic workflow during COVID‐19 pandemic to limit infection risk in dental practice | A novel human coronavirus(SARS‐CoV‐2) causing a severe acute respiratory syndrome, coronavirus disease 2019 (COVID‐19), was reported in Wuhan, China at the end of 2019(Wang, Horby, Hayden, & Gao,2020; Khan, Ali, Siddique, Nabi, 2020).The infectionhas an estimated incubation period of 1‐14 days and its clinical manifest... |
Why Challenge Trials of SARS‐CoV‐2 Vaccines Could Be Ethical Despite Risk of Severe Adverse Events | Human challenge trials to test the efficacy of vaccine candidates against SARS‐CoV‐2, the novel coronavirus behind Covid‐19, could save considerable time and many lives. But they may initially seem unethical because they expose healthy volunteers to a live virus that is killing many people and for which no cure exists.... |
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