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CMR in the era of COVID-19: Evaluation of Myocarditis in the Subacute Phase | [Figure: see text] |
Evaluation of a Web-Based Intervention to Promote Hand Hygiene: Exploratory Randomized Controlled Trial | BACKGROUND: Hand-washing is regarded as a potentially important behavior for preventing transmission of respiratory infection, particularly during a pandemic. OBJECTIVE: The objective of our study was to evaluate whether a Web-based intervention can encourage more frequent hand-washing in the home, and to examine poten... |
The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome | BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-γ,TNF-α and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested ... |
Application of ‘mobile hospital’ against 2019-nCoV in China | |
Comment on “Are erythema multiforme and urticaria related to a better outcome of COVID 19?”. Eosinophils count in 7 patients with COVID‐19 and urticarial rash. | |
The Another Side of COVID‐19 in Alzheimer’s Disease Patients: Drug‐Drug Interactions | Coronavirus Disease 2019 (COVID‐19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has become a major public health problem. The elderly people are the most affected population by the COVID‐19 outbreak in terms of mortality and morbidity. Delirium caused by hypoxia, a prominent clinical... |
Synthesis, antiviral activity and cytotoxicity evaluation of Schiff bases of some 2-phenyl quinazoline-4(3)H-ones | A new series of 3-(benzylideneamino)-2-phenylquinazoline-4(3H)-ones were prepared through Schiff base formation of 3-amino-2-phenyl quinazoline-4(3)H-one with various substituted carbonyl compounds. Their chemical structures were elucidated by spectral studies. Cytotoxicity and antiviral activity were evaluated against... |
Feline Foamy Virus Infection: Characterization of Experimental Infection and Prevalence of Natural Infection in Domestic Cats with and without Chronic Kidney Disease | Foamy viruses (FVs) are globally prevalent retroviruses that establish apparently apathogenic lifelong infections. Feline FV (FFV) has been isolated from domestic cats with concurrent diseases, including urinary syndromes. We experimentally infected five cats with FFV to study viral kinetics and tropism, peripheral blo... |
Detection of yellow head virus in shrimp by loop-mediated isothermal amplification (LAMP) | Abstract Reverse transcription loop-mediated isothermal amplification (RT-LAMP) assay was developed for detecting the structural glycoprotein gene of yellow head virus (YHV). The RT-LAMP assay is a novel method of gene amplification that amplifies nucleic acid with high specificity, sensitivity and rapidity under isoth... |
Letter to the Editor: “Embracing Disruptive Change During the SARS-CoV 2 Pandemic” | |
Visualising COVID-19 Pandemic Risk through Network Connectedness | Abstract With the domestic and international spread of the COVID-19, much attention has been given to estimating pandemic risk. We propose the use of a novel application of a well-established scientific approach, network analysis, to provide a direct visualisation (the infographics in Figures 1 and 2) of the COVID-19 p... |
Hydroxychloroquine for the Prevention of Covid-19 — Searching for Evidence | |
Antibodies and vaccines against Middle East respiratory syndrome coronavirus | The Middle East respiratory syndrome coronavirus (MERS-CoV) has spread through 27 countries and infected more than 2,200 people since its first outbreak in Saudi Arabia in 2012. The high fatality rate (35.4%) of this novel coronavirus and its persistent wide spread infectiousness in animal reservoirs have generated tre... |
Lack of association between polymorphisms of MASP2 and susceptibility to SARS coronavirus infection | BACKGROUND: The pathogenesis of severe acute respiratory disease syndrome (SARS) is not fully understood. One case-control study has reported an association between susceptibility to SARS and mannan-binding lectin (MBL) in China. As the downstream protein of MBL, variants of the MBL-associated serine protease-2 (MASP2)... |
Pathologic Features of COVID-19: A Concise Review | The novel coronavirus disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), first appeared in December 2019, in Wuhan, China and evolved into a pandemic. As Angiotensin-Converting Enzyme 2 (ACE2) is one of the potential target receptors for SARS-CoV-2 in human body, which is e... |
Pedestrian-level wind conditions in the space underneath lift-up buildings | Abstract Lift-up buildings are advantageous in improving the wind circulation in a congested and compact city. However, the wind conditions in the void underneath a lift-up building, also known as the lift-up area, are vital for wind comfort of occupants of lift-up buildings. This study tested 28 lift-up buildings in a... |
A systematic review of the overlap of fluid biomarkers in delirium and advanced cancer-related syndromes | BACKGROUND: Delirium is a serious and distressing neurocognitive disorder of physiological aetiology that is common in advanced cancer. Understanding of delirium pathophysiology is largely hypothetical, with some evidence for involvement of inflammatory systems, neurotransmitter alterations and glucose metabolism. To d... |
Global issues related to enteric viral infections | Acute viral gastroenteritis is a major health issue worldwide and is associated with high annual mortality, particularly in children of developing countries. Rotaviruses, caliciviruses and astroviruses are the main causes. Accurate diagnoses are possible by recently developed molecular techniques. In many setups, zoono... |
Clinical Characteristics and Outcome in Patients with Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State Associated with COVID-19: A Retrospective, Hospital-Based Observational Case Series | AIM: One of the risk factors for poor outcome with SARS-CoV-2 infection is diabetes mellitus; diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS) are the most serious complications of diabetes mellitus. We aimed to explore the clinical characteristics and outcomes of COVID-19 patients presenting with... |
Taking forward the World TB Day 2016 theme ‘Unite to End Tuberculosis’ for the WHO Africa Region | Summary Tuberculosis (TB) remains a global emergency, with an estimated 9.6 million new TB cases worldwide reported in 2014. Twenty-eight percent of these cases were in the World Health Organization (WHO) Africa Region, where the annual case detection rate was 281 per 100000 population—more than double the global avera... |
Factors associated with nosocomial SARS-CoV transmission among healthcare workers in Hanoi, Vietnam, 2003 | BACKGROUND: In March of 2003, an outbreak of Severe Acute Respiratory Syndrome (SARS) occurred in Northern Vietnam. This outbreak began when a traveler arriving from Hong Kong sought medical care at a small hospital (Hospital A) in Hanoi, initiating a serious and substantial transmission event within the hospital, and ... |
DNA single-base mismatch study with an electrochemical enzymatic genosensor | A thorough selectivity study of DNA hybridization employing an electrochemical enzymatic genosensor is discussed here. After immobilizing on a gold film a 30-mer 3′-thiolated DNA strand, hybridization with a biotinylated complementary one takes place. Then, alkaline phosphatase is incorporated to the duplex through the... |
Influence of Oyster Mushroom Waste on Growth Performance, Immunity and Intestinal Morphology Compared With Antibiotics in Broiler Chickens | Oyster mushroom waste (OMW) is a by-product of the agriculture industry with valuable antimicrobial, antioxidant, antifungal, and prebiotic properties. This by-product might be a useful alternative to antibiotic growth stimulators in poultry nutrition. The purpose of this research was to test the impact of OMW on the i... |
COVID-19-Related Economic Anxiety Is As High as Health Anxiety: Findings from the USA, the UK, and Israel | As the COVID-19 outbreak peaks, millions of individuals are losing their income, and economic anxiety is felt worldwide. In three different countries (the USA, the UK, and Israel: N = 1200), the present study addresses four different sources of anxiety: health-related anxiety, economic-related anxiety, daily routine-ch... |
Nasopharyngeal microbiota in infants and changes during viral upper respiratory tract infection and acute otitis media | BACKGROUND: Interferences between pathogenic bacteria and specific commensals are known. We determined the interactions between nasopharyngeal microbial pathogens and commensals during viral upper respiratory tract infection (URI) and acute otitis media (AOM) in infants. METHODS: We analyzed 971 specimens collected mon... |
Identification of Protein Interaction Partners in Mammalian Cells Using SILAC-immunoprecipitation Quantitative Proteomics | Quantitative proteomics combined with immuno-affinity purification, SILAC immunoprecipitation, represent a powerful means for the discovery of novel protein:protein interactions. By allowing the accurate relative quantification of protein abundance in both control and test samples, true interactions may be easily disti... |
Cyclooxygenase activity is important for efficient replication of mouse hepatitis virus at an early stage of infection | Cyclooxygenases (COXs) play a significant role in many different viral infections with respect to replication and pathogenesis. Here we investigated the role of COXs in the mouse hepatitis coronavirus (MHV) infection cycle. Blocking COX activity by different inhibitors or by RNA interference affected MHV infection in d... |
A Specialized Few Among Many: Identification of a Novel Lung Epithelial Stem Cell Population | Summary The landscape of lung epithelial stem cells is getting more nuanced. In this issue of Cell Stem Cell, Kathiriya et al. (2020) describe a novel distal airway epithelial cell population with high regenerative potential. |
Ensuring adequate health financing to prevent and control the COVID-19 in Iran | On February 19(th) 2020, the Iranian Ministry of Health and Medical Education (MoHME) has announced the first 2 cases of SARS-CoV-2, a novel emerging coronavirus which causes an infection termed as COVID-19, in Qom city. As such, the Iranian government, through the establishment of the “National Headquarters for the ma... |
A Snapshot of the Global Race for Vaccines Targeting SARS-CoV-2 and the COVID-19 Pandemic | A novel coronavirus SARS-CoV-2 causing Coronavirus disease 2019 (COVID-19) has entered the human population and has spread rapidly around the world in the first half of 2020 causing a global pandemic. The virus uses its spike glycoprotein receptor-binding domain to interact with host cell angiotensin-converting enzyme ... |
Drugs to cure avian influenza infection – multiple ways to prevent cell death | New treatments and new drugs for avian influenza virus (AIV) infection are developed continually, but there are still high mortality rates. The main reason may be that not all cell death pathways induced by AIV were blocked by the current therapies. In this review, drugs for AIV and associated acute respiratory distres... |
A real option analysis for stochastic disease control and vaccine stockpile policy: An application to H1N1 in Korea | Abstract Vaccination is mostly used for controlling the diffusion of an infectious disease. This paper attempts to bridge a gap between economic model and epidemiological model to analyze the optimal vaccination strategy when the diffusion of pandemic disease follows a stochastic process. Impulsive vaccination is consi... |
Characterization of the Virus of Sialodacryoadenitis of Rats: A Member of the Coronavirus Group | The virus that causes sialodacryoadenitis in rats has been isolated in mice and in primary cultures of rat-kidney cells and has been characterized as a heat-labile RNA virus that is sensitive to lipid solvents and is relatively stable at pH 3.0. This virus is antigenically related to the virus of hepatitis in mice and ... |
Comparative analysis of viral RNA signatures on different RIG-I-like receptors | The RIG-I-like receptors (RLRs) play a major role in sensing RNA virus infection to initiate and modulate antiviral immunity. They interact with particular viral RNAs, most of them being still unknown. To decipher the viral RNA signature on RLRs during viral infection, we tagged RLRs (RIG-I, MDA5, LGP2) and applied tag... |
Covid-19 pandemic impact on colonoscopy service and suggestions for managing recovery | Background and aim As the post-peak phase of the epidemic is approaching, there is an urgent need of an action plan to help resume endoscopy activity. To manage the Covid-19 pandemic-imposed backlog of postponed colonoscopy examinations, an efficient approach is needed. The practice of on-demand sedation with benzodiaz... |
Pos Covid-19 And The Portuguese National Eye Care System Challenge | Abstract The pandemic of the severe acute respiratory syndrome disease caused by the new coronavirus SARS-CoV-2 (COVID-19), had profound impact in many countries and their health care systems. Regarding Portugal, a suppression strategy with social distancing was adopted, attempting to break the transmission chains, ben... |
BILL E. KUNKLE INTERDISCIPLINARY BEEF SYMPOSIUM: Impact of mineral and vitamin status on beef cattle immune function and health(,) | The importance of optimal mineral and vitamin nutrition on improving immune function and health has been recognized in the preceding decades. In the southeast, beef cattle are raised predominantly on forages that may be limiting in nutrients for optimal health, especially trace minerals such as Cu, Zn, and Se. Clinical... |
Astroviruses | Astroviruses are positive-sense, single-stranded RNA viruses. Their genomes contain three open reading frames, but the exact number of encoded proteins remains unknown. Astroviruses were originally identified in association with childhood diarrhea; subsequently, they have been identified as a common enteric virus infec... |
Animal toxins — Nature’s evolutionary-refined toolkit for basic research and drug discovery | Venomous animals have evolved toxins that interfere with specific components of their victim’s core physiological systems, thereby causing biological dysfunction that aids in prey capture, defense against predators, or other roles such as intraspecific competition. Many animal lineages evolved venom systems independent... |
Isolating children is not the answer to COVID‐19 | |
Chapter 32 Nidoviruses of Fish and Crustaceans | Abstract Viruses with diverse virion architectures demarcated into four families in the order Nidovirales have been discovered in vertebrate mammalian and fish species, as well as in invertebrate crustacean and mosquito species. The order is unified by nidoviruses sharing intermediate (12.7kb) to very long (31.7kb) (+)... |
Les réanimations françaises se mobilisent : un exemple d’organisation régionale contre l’épidémie de COVID-19 | |
ESTs analyses of Lampetra japonica liver and comparation transcriptome with the jawed vertebrates | A cDNA library was constructed from the liver of Lampetra japonica. 10077 ESTs were obtained by random selecting clones for sequencing. The results demonstrated that 8515 ESTs were assembled into 648 consensus sequences, represented 2210 unique transcripts, 47.06% of which were predicted as full length cDNAs. In additi... |
Bacterial Artificial Chromosome-Based Lambda Red Recombination with the I-SceI Homing Endonuclease for Genetic Alteration of MERS-CoV | Over the past two decades, several coronavirus (CoV) infectious clones have been engineered, allowing for the manipulation of their large viral genomes (~30 kb) using unique reverse genetic systems. These reverse genetic systems include targeted recombination, in vitro ligation, vaccinia virus vectors, and bacterial ar... |
The association between severe or death COVID-19 and autoimmune disease: a systematic review and meta-analysis | |
META-ANALYSES ON DOUBLE-BLIND RCTS ADDING DRUGS WITH ANTI-INFLAMMATORY PROPERTIES TO ANTIPSYCHOTIC MEDICATION | |
The impact of cold on the respiratory tract and its consequences to respiratory health | The increasing use, and sometimes the abuse, particularly in industrialized countries of air conditioning at home, in car, hotel and shopping centres has highlighted new emerging public health issues, resulting from exposure of the airways to cool air or, more properly, resulting from sudden temperature changes. This i... |
Isolation and Propagation of Coronaviruses in Embryonated Eggs | The embryonated egg is a complex structure comprised of an embryo and its supporting membranes (chorioallantoic, amniotic, yolk). The developing embryo and its membranes provide the diversity of cell types that are needed for successful replication of a wide variety of different viruses. Within the family Coronaviridae... |
Fact-finding Survey of Nosocomial Infection Control in Hospitals in Kathmandu, Nepal—A Basis for Improvement | The purpose of this study was to investigate the actual conditions of nosocomial infection control in Kathmandu City, Nepal as a basis for the possible contribution to its improvement. The survey was conducted at 17 hospitals and the methods included a questionnaire, site visits and interviews. Nine hospitals had manua... |
Is there an ideal animal model for SARS? | The outbreak of severe acute respiratory syndrome (SARS) in 2003 was controlled by public health measures at a time when specific interventions such as antiviral drugs, vaccines and immunotherapy were not available. Since then, several animal models have been developed for the study of SARS and, although no model repli... |
Early Transmission Dynamics of Novel Coronavirus (COVID-19) in Nigeria | On 31 December 2019, the World Health Organization (WHO) was notified of a novel coronavirus disease in China that was later named COVID-19. On 11 March 2020, the outbreak of COVID-19 was declared a pandemic. The first instance of the virus in Nigeria was documented on 27 February 2020. This study provides a preliminar... |
Clustered Cases of Pneumonia among Healthcare Workers over a 1-year Period in Three Italian Hospitals: Applying the WHO SARS Alert | BACKGROUND: The World Health Organization (WHO) has recommended that a severe acute respiratory syndrome (SARS) alert should be raised when two or more healthcare workers (HCW) in the same health care unit fulfil the SARS clinical criteria, with onset of illness in the same 10-day period. However, in a number of Europe... |
Grouper interferon-induced transmembrane protein 3 (IFITM3) inhibits the infectivity of iridovirus and nodavirus by restricting viral entry | Interferon-induced transmembrane proteins (IFITMs) have been identified as important host restriction factors in mammals for the control of infection by multiple viruses. However, the antiviral functions of IFITMs against fish viruses remain largely uncertain. In this study, the IFITM3 homolog from orange spotted group... |
Ingestion of Exopolymers from Aureobasidium pullulans Reduces the Duration of Cold and Flu Symptoms: A Randomized, Placebo-Controlled Intervention Study | AIM: The objective of the study was to assess the efficacy of exopolymers from Aureobasidium pullulans (EAP) on the incidence of colds and flu in healthy adults. METHODS: We conducted a randomized, double-blind, placebo-controlled study at the onset of the influenza season. A total of 76 subjects (30–70 years of age) w... |
Estimation and tests for power-transformed and threshold GARCH models | Abstract Consider a class of power-transformed and threshold GARCH ( p , q ) (PTTGRACH ( p , q ) ) model, which is a natural generalization of power-transformed and threshold GARCH(1,1) model in Hwang and Basawa [2004. Stationarity and moment structure for Box–Cox transformed threshold GARCH(1,1) processes. Statistics ... |
The RNA capping machinery as an anti‐infective target | A number of different human pathogens code for their own enzymes involved in the synthesis of the RNA cap structure. Although the RNA cap structures originating from human and microbial enzymes are often identical, the subunit composition, structure and catalytic mechanisms of the microbial‐encoded enzymes involved in ... |
Harnessing resolving‐based therapeutics to treat pulmonary viral infections: What can the future offer to COVID‐19? | Inflammation is generally believed to be a protective response in the context of infectious diseases. However, altered inflammatory responses can contribute to disease in infected individuals. Multiple mediators that drive the resolution of inflammation have been described. Overall, mediators of resolution tend to decr... |
Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom | • Venous thrombosis is common in patients with severe COVID-19 pneumonia. • Many of these thromboses may be immunothromboses due to local inflammation, rather than thromboembolic disease. • Anticoagulated patients with COVID-19 pneumonia have a risk of major bleeding. |
Differential Regulation of Self-reactive CD4(+) T Cells in Cervical Lymph Nodes and Central Nervous System during Viral Encephalomyelitis | Viral infections have long been implicated as triggers of autoimmune diseases, including multiple sclerosis (MS), a central nervous system (CNS) inflammatory demyelinating disorder. Epitope spreading, molecular mimicry, cryptic antigen, and bystander activation have been implicated as mechanisms responsible for activat... |
Social Factors Associated with AIDS and SARS | We conducted a survey of 928 New York City area residents to assess knowledge and worry about AIDS and SARS. Specific sociodemographic groups of persons were more likely to be less informed and more worried about contracting the diseases. |
A review of medical masks and respirators for use during an influenza pandemic | |
Calendrier vaccinal des nourrissons et COVID-19 | |
HIV-1 Modulates the tRNA Pool to Improve Translation Efficiency | Despite its poorly adapted codon usage, HIV-1 replicates and is expressed extremely well in human host cells. HIV-1 has recently been shown to package non-lysyl transfer RNAs (tRNAs) in addition to the tRNA(Lys) needed for priming reverse transcription and integration of the HIV-1 genome. By comparing the codon usage o... |
Medical care of atrophic gastritis patients during COVID-19 pandemic: results of telemedicine in a referral center | |
Large-scale production and purification of VLP-based vaccines | Abstract Virus-like particles (VLPs) hold tremendous potential as vaccine candidates. These innovative biopharmaceuticals present the remarkable advantages of closely mimicking the three-dimensional nature of an actual virus while lacking the virus genome packaged inside its capsid. As a result, an equally efficient bu... |
Natural mutations in IFITM3 modulate post‐translational regulation and toggle antiviral specificity | The interferon‐induced transmembrane (IFITM) proteins protect host cells from diverse virus infections. IFITM proteins also incorporate into HIV‐1 virions and inhibit virus fusion and cell‐to‐cell spread, with IFITM3 showing the greatest potency. Here, we report that amino‐terminal mutants of IFITM3 preventing ubiquiti... |
Severe human parechovirus sepsis beyond the neonatal period | Abstract Here we describe a case of viral sepsis beyond the neonatal period caused by human parechovirus subtype 3 (HPeV-3), which manifested as cardio-respiratory failure, hepatitis, and necrotizing enterocolitis (NEC). HPeV-1 and 2 were originally classified as enteroviruses but the advent of sequence analysis led to... |
Atypical pneumonia—time to breathe new life into a useful term? | Summary The term atypical pneumonia was originally used to describe an unusual presentation of pneumonia. It is now more widely used in reference to either pneumonia caused by a relatively common group of pathogens, or to a distinct clinical syndrome the existence of which is difficult to demonstrate. As such, the use ... |
Chapter 8 Business Strategies and Risk Factors | The offshore pipeline construction service industry has seen varying degrees of consolidation and integration over the years. The demand for pipeline construction fluctuates from year to year and by geographic region. During periods of sustained low oil prices demand for services are reduced, causing contractors to res... |
Chloroquine, Hydroxychloroquine and Hearing Loss: A Study in Systemic Lupus Erythematosus Patients | OBJECTIVES/HYPOTHESIS: Antimalarial drugs (chloroquine and hydroxychloroquine) are widely used for the treatment of systemic lupus erythematosus (SLE). However, these drugs may have side effects such as hearing loss. This study aimed to describe the hearing function in SLE patients using antimalarials. Secondarily, thi... |
Modeling particle dispersion and deposition in indoor environments | Abstract Particle dispersion and deposition in man-made enclosed environments are closely related to the well-being of occupants. The present study developed a three-dimensional drift-flux model for particle movements in turbulent indoor airflows, and combined it into Eulerian approaches. To account for the process of ... |
Inflammatory cerebrospinal fluid analysis in cats: clinical diagnosis and outcome | The medical records of 62 cats with clinical signs of central nervous system disease and accompanying inflammatory cerebrospinal fluid (CSF) analysis were examined retrospectively to determine if signalment, clinical signs, CSF analysis and ancillary testing could accurately predict the type of central nervous system d... |
Unique reassortant of influenza A(H7N9) virus associated with severe disease emerging in Hong Kong | Summary Objective Human infections caused by avian influenza virus A(H7N9) re-emerged in late 2013. We reported the first Hong Kong patient without risk factors for severe A(H7N9) disease. Methods Direct sequencing was performed on the endotracheal aspirate collected from a 36-year-old female with history of poultry co... |
Practical Considerations for Solid Organ Transplantation During the COVID-19 Global Outbreak: The Experience from Singapore | The current coronavirus disease 2019 (COVID-19) pandemic has not only caused global social disruptions but has also put tremendous strain on healthcare systems worldwide. With all attention and significant effort diverted to containing and managing the COVID-19 outbreak (and understandably so), essential medical servic... |
Troubling care in the neonatal intensive care unit | The neonatal intensive care unit (NICU) is a site of medical treatment for premature and critically ill infants. It is a space populated by medical teams and their patients, as well as parents and family. Each actor in this space negotiates providing and practicing care. In this paper, we step away from thinking about ... |
How medical education can help in a COVID‐19 crisis | |
A prospective prediction tool for understanding Crimean–Congo haemorrhagic fever dynamics in Turkey | Abstract Objectives We aimed to develop a prospective prediction tool on Crimean–Congo haemorrhagic fever (CCHF) to identify geographic regions at risk. The tool could support public health decision-makers in implementation of an effective control strategy in a timely manner. Methods We used monthly surveillance data b... |
The Environment and Well-Being in Urban China | Abstract We examine the relationship between atmospheric pollution, measured as sulphur dioxide emissions, environmental disasters, traffic congestion, access to parkland and well-being in urban China, using a large survey administered across 30 cities in 2003. We find that in cities with high levels of atmospheric pol... |
RNA structure interactions and ribonucleoprotein processes of the influenza A virus | In one more years, we will ‘celebrate’ an exact centenary of the Spanish flu pandemic. With the rapid evolution of the influenza virus, the possibility of novel pandemic remains ever a concern. This review covers our current knowledge of the influenza A virus: on the role of RNA in translation, replication, what is kno... |
Chapter 504 Sindbis Virus nsP2 Endopeptidase | The third edition of the Handbook of Proteolytic Enzymes aims to be a comprehensive reference work for the enzymes that cleave proteins and peptides, and contains over 800 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biol... |
Successful Outcome of Human Metapneumovirus (hMPV) Pneumonia in a Lung Transplant Recipient Treated With Intravenous Ribavirin | Human metapneumovirus (hMPV) has recently been shown to be a prominent cause of respiratory infections in immunocompromised hosts, and is associated with high morbidity and mortality. We report a case of hMPV pneumonia in a lung transplant recipient presenting with respiratory failure and sepsis syndrome. hMPV was diag... |
Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype | Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of pro-inflammatory cytokine signaling, TLR signaling, and inflammatory gene expression. Furthermore, mice genetically lacking SHP-1 (me/me) display a profound susceptibility to inflammatory CNS demyelin... |
SARS: prognosis, outcome and sequelae | Severe acute respiratory syndrome (SARS) is associated with considerable morbidity and mortality in the acute phase. Worldwide case fatality rate is 11% (range 7 to 27%) for the most severely affected regions. Several adverse prognostic factors have been identified, including advanced age, presence of comorbidity, high... |
Liver Disease Associated with Non-Hepatitis Viruses | Abstract Hepatitis is commonly associated with certain viruses labeled as “Hepatitis” viruses. However, many other viral infections can also affect the liver ranging from mild asymptomatic elevations of aminotransferases to fulminant hepatic failure. This article will provide a brief overview on a variety of different ... |
Bladder acellular matrix graft: in vivo functional properties of the regenerated rat bladder | The purpose of this study was to determine whether the rat urinary bladder augmented by an acellular matrix graft can restore the bladder's low-pressure reservoir function and preserve normal micturition. After partial cystectomy (>50%) and grafting with the bladder acellular matrix graft (BAMG), storage and voiding fu... |
Collection efficiencies of aerosol samplers for virus-containing aerosols | Abstract Collection efficiencies of four bioaerosol samplers (Andersen impactor, AGI-30 impinger, gelatin filter, and nuclepore filter) were evaluated for virus-containing aerosols. Four different bacteriophages were used as surrogates for the mammalian viruses. Results showed that the collection efficiency was signifi... |
Improving the collection efficiency of the liquid impinger for ultrafine particles and viral aerosols by applying granular bed filtration | Abstract Liquid impingers are utilized to collect bioaerosols for many advantages, such as avoiding dehydration of biological agents. However, many previous studies have reported that the liquid impingers are surprisingly inefficient for the collection of ultrafine bioaerosols, with collection efficiencies <30%. In the... |
Comprehensive Biothreat Cluster Identification by PCR/Electrospray-Ionization Mass Spectrometry | Technology for comprehensive identification of biothreats in environmental and clinical specimens is needed to protect citizens in the case of a biological attack. This is a challenge because there are dozens of bacterial and viral species that might be used in a biological attack and many have closely related near-nei... |
Neutrophil-to-lymphocyte ratio as a predictive biomarker for moderate-severe ARDS in severe COVID-19 patients | ChiCTR, ChiCTR2000029758. Registered 12 February 2020 - Retrospectively registered |
Differential COVID-19 case positivity in New York City neighborhoods: socioeconomic factors and mobility | New York City has been one of the hotspots of the COVID-19 pandemic and during the first two months of the outbreak considerable variability in case positivity was observed across the city's ZIP codes. In this study, we examined: a) the extent to which the variability in ZIP code level cases can be explained by aggrega... |
Initiating respiratory hygiene and cough etiquette stations throughout a multihospital university medical center | ISSUE: In September 2003, the state health department, along with our facility, mandated that we develop a response plan for the possible re-emergence of Severe Acute Respiratory Syndrome (SARS). We convened a multidisciplinary SARS task force, and five team members were given responsibility for writing the plan. Durin... |
Pharyngitis | Abstract “Sore throat” or pharyngitis is one of the most frequent complaints of patients in the acute care setting, accounting for nearly 7 million pediatric and 6 million adult visits each year. On the surface, pharyngitis would appear to pose few challenges to the clinician; the site of infection is both visible and ... |
The future of Telemedicine Cabin? The case of the French students’ acceptability() | Telemedicine could solve the problem of the lack of infrastructure and insufficient number of qualified healthcare staff in many countries/regions. The aim of this research is to investigate the futures of such solution by having a better understanding of the acceptance of the Telemedicine Cabin by high-educated Millen... |
Geographic variation in the aetiology, epidemiology and microbiology of bronchiectasis | Bronchiectasis is a disease associated with chronic progressive and irreversible dilatation of the bronchi and is characterised by chronic infection and associated inflammation. The prevalence of bronchiectasis is age-related and there is some geographical variation in incidence, prevalence and clinical features. Most ... |
Hemoptysis in COVID-19: Observation | |
Chapter 19 Disease resistance for different livestock species | Abstract This chapter deals with progress in disease resistance for the livestock population species-wise and describes the progress that occurred globally. Certain genes were identified for mastitis resistance and the strategies for genomic control of mastitis are discussed. Gene-edited tuberculosis-resistant cattle w... |
Recombination in Eukaryotic Single Stranded DNA Viruses | Although single stranded (ss) DNA viruses that infect humans and their domesticated animals do not generally cause major diseases, the arthropod borne ssDNA viruses of plants do, and as a result seriously constrain food production in most temperate regions of the world. Besides the well known plant and animal-infecting... |
Evaluation of a two-stage testing algorithm for the diagnosis of respiratory viral infections | Abstract New on-demand multiplex molecular respiratory viral diagnostics offer superior performance although can be expensive and some platforms cannot process multiple specimens simultaneously. We performed a retrospective study reviewing results of patients tested for respiratory viruses following introduction of a t... |
Diagnostic Methods for Feline Coronavirus: A Review | Feline coronaviruses (FCoVs) are found throughout the world. Infection with FCoV can result in a diverse range of signs from clinically inapparent infections to a highly fatal disease called feline infectious peritonitis (FIP). FIP is one of the most serious viral diseases of cats. While there is neither an effective v... |
Authors’ response to letter by Fogacci, Borghi and Cicero, “Misinterpreting data in lipidology in the era of COVID-19” |
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