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Clinical characteristics and therapeutic procedure for a critical case of novel coronavirus pneumonia treated with glucocorticoids and non-invasive ventilator treatment | The novel coronavirus pneumonia (NCP) outbreak occurred in Wuhan, China at the end of 2019. Here, we report the clinical characteristics and therapeutic procedure for a case of severe NCP. The patient was started on glucocorticoids and non-invasive ventilator treatment. After treatment, the patient’s symptoms improved,... |
COVID‐19: From pathogenesis models to the first drug trials | The number of people infected with SARS‐CoV‐2, and sadly dying from COVID‐19, has exploded, and so the amount of literature on the novel coronavirus and the disease it causes has increased proportionately. The case numbers in some countries are beyond the epidemic peak, but the uncertainty about a second wave keeps pol... |
Severe maternal morbidity and mortality associated with COVID‐19: The risk should not be down‐played | Nordic countries have a long tradition of collecting health related population data meticulously and reporting them transparently. Such data provide firm grounds for making good decisions and as a result the public health institutions in Scandinavia enjoy the trust of society. The Covid‐19 pandemic has, however, result... |
Association between dopamine and cerebral autoregulation in preterm neonates | BACKGROUND: To test the hypothesis that dopamine is associated with impaired cerebral autoregulation (ICA) in a dose-dependent fashion. METHODS: Non a priori designed secondary analysis of a prospectively enrolled cohort study subjects <12 h of life between 24(0) and 29(6) weeks gestation. Cerebral saturations (rScO2) ... |
Informing Emergency Care for all patients: The Registry for Emergency Care (REC) Project Protocol | OBJECTIVES: In Australia, the current emergency department (ED) burden related to COVID‐19 is from ‘suspected’ rather than ‘confirmed’ cases. The initial aim of the Registry for Emergency Care (REC) Project is to determine the impact of isolation processes on the emergency care of all patients. METHODS: The REC Project... |
Lessons learned from HIV can inform our approach to COVID‐19 stigma | |
Outcome of phacoemulsification in 71 cats: A multicenter retrospective study (2006‐2017) | PURPOSE: To assess outcome of phacoemulsification in cats. METHODS: Records of 71 cats (82 eyes) from five referral centers were reviewed. Groups were divided by cause of cataract (congenital/juvenile [n = 32], traumatic [n = 33], and secondary to uveitis [n = 6]), and group comparisons were performed for the most comm... |
The history and epidemiology of Middle East respiratory syndrome corona virus | Corona viruses cause common cold, and infections caused by corona viruses are generally self-resolving. During the last 4 years, corona viruses have become the most important viruses worldwide because of the occurrence of several recent deaths caused by corona viruses in Saudi Arabia. Spread of the infection occurred w... |
Infectious MERS-CoV Isolated From a Mildly Ill Patient, Saudi Arabia | Middle East respiratory syndrome coronavirus (MERS-CoV) is associated with a wide range of clinical presentations, from asymptomatic or mildly ill to severe respiratory illness including death. We describe isolation of infectious MERS-CoV from the upper respiratory tract of a mildly ill 27-year-old female in Saudi Arab... |
Coronavirus Disease 2019: A Gastroenterologist’s Perspective in May 2020 | We are in the middle of coronavirus disease 2019 (COVID-19) pandemic which has affected every aspect of human life all over the world. Although COVID-19 primarily affects the lungs, it is in fact a multisystem disorder causing high mortality and panicking the whole world. Gastrointestinal (GI) manifestations of this di... |
Which type of cancer patients are more susceptible to the SARS-COX-2: evidence from a meta-analysis and bioinformatics analysis | OBJECTIVE: Numerous studies have reported that patients with cancer seem to be more likely to be diagnosed with COVID-19. However, it is still unknown the prevalence of different types of cancer in patients with COVID-19. Therefore, this study will explore which type of cancer patients are more susceptible to the SARS-... |
Immunopathogenesis of coronavirus infections: implications for SARS | At the end of 2002, the first cases of severe acute respiratory syndrome (SARS) were reported, and in the following year, SARS resulted in considerable mortality and morbidity worldwide. SARS is caused by a novel species of coronavirus (SARS-CoV) and is the most severe coronavirus-mediated human disease that has been d... |
Profile–profile comparisons by COMPASS predict intricate homologies between protein families | Recently we proposed a novel method of alignment–alignment comparison, COMPASS (the tool for COmparison of Multiple Protein Alignments with Assessment of Statistical Significance). Here we present several examples of the relations between PFAM protein families that were detected by COMPASS and that lead to the predicti... |
Partial Purification of IBV and Subsequent Isolation of Viral RNA for Next-Generation Sequencing | RNA viruses are known for a high mutation rate and rapid genomic evolution. As such an RNA virus population does not consist of a single genotype but is rather a collection of individual viruses with closely related genotypes—a quasispecies, which can be analyzed by next-generation sequencing (NGS). This diversity of g... |
Control of the PI3K/Akt pathway by porcine reproductive and respiratory syndrome virus | Phosphatidylinositol-3-kinase (PI3K)/Akt is an important cellular pathway that has been shown to participate in various replication steps of multiple viruses. In the present study, we compared the phosphorylation status of Akt during infection of MARC-145 cells and porcine alveolar macrophages (PAMs) with highly pathog... |
Pandemic preparedness of community pharmacies for COVID-19: A cross-sectional survey | BACKGROUND: Community pharmacies provide an important healthcare service, which is broadly established, and constitutes the preferred and initial contact for members of the community. The significant value of community pharmacies was further highlighted during the COVID-19 pandemic crisis. OBJECTIVE: The assessment of ... |
Right Ventricular Function and Pulmonary Pressures as Independent Predictors of Survival in Patients With COVID-10 Pneumonia | |
Delivery technologies for human vaccines | There is currently intense research activity aimed at the development of new delivery systems for vaccines. The goal is to identify optimal methods for presenting target antigens to the immune system in a manner that will elicit immune responses appropriate for protection against, or treatment of, a specific disease. S... |
Negative pressure of the environmental air in the cleaning area of the materials and sterilization center: a systematic review | OBJECTIVE: to analyze the scientific evidence on aerosols generated during cleaning activities of health products in the Central Service Department (CSD) and the impact of the negative pressure of the ambient air in the cleaning area to control the dispersion of aerosols to adjacent areas. METHOD: for this literature s... |
A call to action for public health nurses during the COVID‐19 pandemic | Public health nurses (PHNs) are on the frontline of the public health crisis the world now knows as the COVID-19 pandemic. They serve on mobile strike teams investigating case-contacts, deliver education on self-isolation and quarantine through hotlines and home visits, and interpret the rapidly shifting guidance from ... |
Viral Infection in the Development and Progression of Pediatric Acute Respiratory Distress Syndrome | Viral infections are an important cause of pediatric acute respiratory distress syndrome (ARDS). Numerous viruses, including respiratory syncytial virus (RSV) and influenza A (H1N1) virus, have been implicated in the progression of pneumonia to ARDS; yet the incidence of progression is unknown. Despite acute and chroni... |
Agents and Robots for Collaborating and Supporting Physicians in Healthcare Scenarios | Monitoring patients through robotics telehealth systems is an interesting scenario where patients’ conditions, and their environment, are dynamic and unknown variables. We propose to improve telehealth systems’ features to include the ability to serve patients with their needs, operating as human caregivers. The object... |
Longitudinal study of interventional radiology activity in a large metropolitan Italian tertiary care hospital: how the COVID-19 pandemic emergency has changed our activity | OBJECTIVES: To retrospectively analyze interventional radiology (IR) activity changes in the COVID-19 era and to describe how to safely and effectively reorganize IR activity. METHODS: All IR procedures performed between January 30 and April 8, 2020 (COVID-era group) and the same 2019 period (non-COVID-era group) were ... |
Is Higher Viral Load in the Upper Respiratory Tract Associated With Severe Pneumonia? Findings From the PERCH Study | BACKGROUND. The etiologic inference of identifying a pathogen in the upper respiratory tract (URT) of children with pneumonia is unclear. To determine if viral load could provide evidence of causality of pneumonia, we compared viral load in the URT of children with World Health Organization–defined severe and very seve... |
Viral Etiology of Influenza-Like Illnesses in Cameroon, January–December 2009 | Background. No information is available on the viral etiology of upper respiratory tract infections in Cameroon. Methods. We prospectively enrolled outpatients with influenza-like illness (ILI) presenting at 14 sentinel clinics located across the country from January through December 2009. The specimens were tested usi... |
Interdependent Citizens: The Ethics of Care in Pandemic Recovery | The crisis of Covid‐19 has forced us to notice two things: our human interdependence and American society's tolerance for what Nancy Krieger has called “inequalities embodied in health inequities,” reflected in data on Covid‐19 mortality and geographies. Care is integral to our recovery from this catastrophe and to the... |
Complement Receptor C5aR1 Inhibition Reduces Pyroptosis in hDPP4-Transgenic Mice Infected with MERS-CoV | Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic virus with a crude mortality rate of ~35%. Previously, we established a human DPP4 transgenic (hDPP4-Tg) mouse model in which we studied complement overactivation-induced immunopathogenesis. Here, to better understand the pathogenesis of MER... |
EARLY REPORT ON THE IMPACT OF COVID-19 OUTBREAK IN NEUROSURGICAL PRACTICE AMONG MEMBERS OF THE LATIN AMERICAN FEDERATION OF NEUROSURGICAL SOCIETIES | Abstract Background The COVID-19 pandemic has caused severe economic consequences by local governmental measures to contain the outbreak1 We provide insight on the impact that healthcare restriction has made on neurosurgical activity in Latin Iberoamerica. METHODS: We performed an internet-based survey among Presidents... |
Adding Colchicine to the Antiretroviral Medication - Lopinavir/Ritonavir (Kaletra) in Hospitalized Patients with Non-Severe Covid-19 Pneumonia: A Structured Summary of a Study Protocol for a Randomized Controlled Trial | OBJECTIVES: Colchicine is a well-known drug, which has been used for years to treat a wide range of rheumatic and inflammatory disorders. It helps break the cycle of inflammation through diverse mechanisms including reducing Intereukin-6, Interleukin-8, Tumour Necrosis Factor-alpha besides controlling oxidative stress ... |
Aspectos medicolegales derivados de la pandemia del COVID-19. | |
Chapter 59 Respiratory Virus Vaccines | Abstract This chapter reviews the main viral pathogens of the respiratory tract, the immune responses they induce, currently available vaccines, and vaccines that are in development to control them. The main viruses responsible for acute respiratory infection in people include respiratory syncytial, influenza, human pa... |
Platelet‐to‐lymphocyte ratio is associated with prognosis in patients with coronavirus disease‐19 | Since December 2019, novel coronavirus infected pneumonia emerged in Wuhan city and rapidly spread throughout China. In severe novel coronavirus pneumonia cases, the number of platelets, their dynamic changes during the treatment, platelet‐to‐lymphocyte ratio (PLR) were a concern. We sought to describe the platelet fea... |
Remdesivir — An Important First Step | |
Principles of Virus Uncoating: Cues and the Snooker Ball | Viruses are spherical or complex shaped carriers of proteins, nucleic acids and sometimes lipids and sugars. They are metastable and poised for structural changes. These features allow viruses to communicate with host cells during entry, and to release the viral genome, a process known as uncoating. Studies have shown ... |
Crystal structure of the receptor binding domain of the spike glycoprotein of human betacoronavirus HKU1 | Human coronavirus (CoV) HKU1 is a pathogen causing acute respiratory illnesses and so far little is known about its biology. HKU1 virus uses its S1 subunit C-terminal domain (CTD) and not the N-terminal domain like other lineage A β-CoVs to bind to its yet unknown human receptor. Here we present the crystal structure o... |
Compassionate drug use: an imperative challenge for Bulgarian health system during COVID-19 | • The health care system in Bulgaria faces unprecedented challenges trying to take control over the pandemic of COVID-19. • The existing national regulation in Bulgaria leads to delayed and difficult access to investigational drugs via compassionate use programs. • The COVID-19 pandemic will initiate a dialogue among h... |
Evaluation of a peptide‐based enzyme immunoassay for anti‐SARS coronavirus IgG antibody | High throughput assays for anti‐SARS‐CoV IgG antibody detection are need for large‐scale epidemiologic studies. The performance of a microplate enzyme immunoassay, DETECT‐SARS™, was evaluated for the detection of anti‐SARS‐CoV IgG antibody. This assay is based on synthetic peptides derived from the nucleocapsid and spi... |
Ribavirin and Interferon Therapy for Critically Ill Patients With Middle East Respiratory Syndrome: A Multicenter Observational Study | BACKGROUND: The objective of this study was to evaluate the effect of ribavirin and recombinant interferon (RBV/rIFN) therapy on the outcomes of critically ill patients with Middle East respiratory syndrome (MERS), accounting for time-varying confounders. METHODS: This is a retrospective cohort study of critically ill ... |
DDX3 functions in antiviral innate immunity through translational control of PACT | It has emerged that DDX3 plays a role in antiviral innate immunity. However, the exact mechanism by which DDX3 functions in antiviral innate immunity remains to be determined. We found that the expression of the protein activator of the interferon‐induced protein kinase (PACT) was regulated by DDX3 in human cells. PACT... |
Zika virus: mapping and reprogramming the entry | BACKGROUND: The flaviviridae family comprises single-stranded RNA viruses that enter cells via clathrin-mediated pH-dependent endocytosis. Although the initial events of the virus entry have been already identified, data regarding intracellular virus trafficking and delivery to the replication site are limited. The pur... |
Human cytomegalovirus and Herpes Simplex type I virus can engage RNA polymerase I for transcription of immediate early genes | Human cytomegalovirus (HCMV) utilizes RNA polymerase II to transcribe viral genes and produce viral mRNAs. It can specifically target the nucleolus to facilitate viral transcription and translation. As RNA polymerase I (Pol I)-mediated transcription is active in the nucleolus, we investigated the role of Pol I, along w... |
Management of breast cancer during COVID‐19 pandemic in Morocco | |
Elucidating biophysical basis of binding of inhibitors to SARS-CoV-2 main protease by using molecular dynamics simulations and free energy calculations | The recent outbreak of novel “coronavirus disease 2019” (COVID-19) has spread rapidly worldwide, causing a global pandemic. In the present work, we have elucidated the mechanism of binding of two inhibitors, namely α-ketoamide and Z31792168, to SARS-CoV-2 main protease (M(pro) or 3CL(pro)) by using all-atom molecular d... |
Clinical features, genetics, and outcome of pediatric patients with hemophagocytic lymphohistiocytosis in Korea: report of a nationwide survey from Korea Histiocytosis Working Party | BACKGROUND: We analyzed a nationwide registry of pediatric patients with hemophagocytic lymphohistiocytosis (HLH) in Korea to assess the clinical and genetic features and treatment outcomes in pediatric HLH. METHODS: The Korea Histiocytosis Working Party retrospectively analyzed data on 251 pediatric patients diagnosed... |
NLRP3 Inflammasome—A Key Player in Antiviral Responses | The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and caspase-1. This complex is crucial to the host's defense against microbes as it promotes IL-1β and IL-18 secretion and induces pyroptosis. NLRP3 recognizes va... |
Buscas na internet sobre medidas de enfrentamento à COVID-19 no Brasil: descrição de pesquisas realizadas nos primeiros 100 dias de 2020/ Búsquedas en Internet sobre medidas para combatir el COVID-19 en Brasil: descripción de las investigaciones realizadas en los primeros 100 días de 2020/ Internet searches for measure... | Resumo Objetivo descrever os perfis de interesse de busca de informações na internet sobre termos relacionados à epidemia da Covid-19 no Brasil. Métodos realizou-se uma pesquisa quantitativa exploratória usando o Google Health Trends; foram analisados dados diários de interesse, definido como probabilidade de consulta ... |
3 Loss of Biological Diversity and Emergence of Infectious Diseases | Abstract: Abiotic factors, climatic factors (such as temperature and rainfall) and biotic factors (such as population density and the structure of host communities and reservoirs) are essential variables in the transmission of infectious or parasitic agents. |
Human Coronavirus NL63 Is Not Detected in the Respiratory Tracts of Children with Acute Kawasaki Disease | Kawasaki disease (KD) is a self-limited, systemic vasculitis of children for which an infectious trigger is suspected. Recently, an association between KD and human coronavirus (HCoV)–New Haven (NH) was reported, on the basis of polymerase chain reaction (PCR) with primers that also amplified HCoV-NL63. We investigated... |
Isolated olfactory cleft involvement in SARS-CoV-2 infection: prevalence and clinical correlates | PURPOSE: Smell alterations are a symptom of COVID-19 and have been associated with olfactory cleft mucosal thickening (OCMT). Although their pathogenesis is unclear, evidences link them to viral neuroinvasive potential. This study aims at estimating the prevalence of OCMT in CT scans of COVID-19 patients and investigat... |
Lung health in a changing world | |
Landscape analysis of pharmacovigilance and related practices among 34 vaccine manufacturers’ from emerging countries | Developing Countries’ Vaccine Manufacturers Network was tasked with the strategic goal of seeking solutions, jointly with manufacturers, for enabling the stable, sustainable supply of quality vaccines to developing countries to increase global immunization. As vaccines are given to millions of healthy people, including... |
Cutaneous manifestations in SARS‐CoV‐2 infection (COVID‐19): a French experience and a systematic review of the literature | Skin manifestations have been increasingly reported in the setting of COVID‐19. However, their incidence and presentation are debated, and the role, direct or undirect, of SARS‐CoV‐2 in their pathogenesis has yet to be determined. In this work, we aimed to analyze our experience in a French referral center and to perfo... |
Recombination in Enteroviruses, a Multi-Step Modular Evolutionary Process | RNA recombination is a major driving force in the evolution and genetic architecture shaping of enteroviruses. In particular, intertypic recombination is implicated in the emergence of most pathogenic circulating vaccine-derived polioviruses, which have caused numerous outbreaks of paralytic poliomyelitis worldwide. Re... |
Carrier proteins for fusion expression of antimicrobial peptides in Escherichia coli | Antimicrobial peptides are an essential component of innate immunity and play an important role in host defence against microbial pathogens. They have received increasing attention recently as potential novel pharmaceutical agents. To meet the requirement for necessary basic science studies and clinical trials, large q... |
Ethical framework for head and neck cancer care impacted by COVID‐19 | The COVID‐19 pandemic has upended head and neck cancer care delivery in ways unforeseen and unprecedented. The impact of these changes parallels other fields in oncology, but is disproportionate due to protective measures and limitations on potentially aerosolizing procedures and related interventions specific to the u... |
Considerations for Obstetric Care during the COVID-19 Pandemic | The novel coronavirus disease 2019 (COVID-19) is a growing pandemic that is impacting daily life across the globe. Though disease is often mild, in high-risk populations, severe disease often leads to intubation, intensive care admission (ICU) admission, and in many cases death. The implications for pregnancy remain la... |
Formulation and efficacy evaluation of the safe and efficient moisturizing snow mushroom hand sanitizer | OBJECTIVES: Snow fungus or snow mushroom or white jelly mushroom (Tremella fuciformis), the edible mushroom, was formulated into hand sanitizer in form of moisturizing alcohol‐based hand rubs (ABHR) gel. METHODS: The stable base ABHRs were developed. The preferred bases were incorporated with various concentrations of ... |
The first evidence of a new genotype of nephropathogenic infectious bronchitis virus circulating in vaccinated and unvaccinated broiler flocks in Algeria | BACKGROUND AND AIM: Avian infectious bronchitis virus (IBV) frequently infects broilers and is responsible for severe economic losses to the poultry industry worldwide. It has also been associated with kidney damage in the broiler flocks. The aim of the present study is to determine the presence of IBV and its possible... |
Monitoring infectious diseases in the big data era | |
Unsupervised cluster analysis of SARS-CoV-2 genomes reflects its geographic progression and identifies distinct genetic subgroups of SARS-CoV-2 virus | Over 10,000 viral genome sequences of the SARS-CoV-2 virus have been made readily available during the ongoing coronavirus pandemic since the initial genome sequence of the virus was released on the open access Virological website (http://virological.org/) early on January 11. We utilize the published data on the singl... |
Cardiopulmonary Resuscitation in Intensive Care Unit patients with COVID-19 | Cardiopulmonary resuscitation (CPR) in SARS-CoV-2-associated disease (COVID-19) patients poses a unique challenge to health care providers due to the risk of viral aerosolization and disease transmission. This has caused some centers to modify existing CPR procedures, limit the duration of CPR or consider avoiding CPR ... |
A combination of mutations in the S1 part of the spike glycoprotein gene of coronavirus MHV-A59 abolishes demyelination | The A59 strain of coronavirus, mouse hepatitis virus (MHV), produces acute hepatitis, meningoencephalitis, and chronic demyelination. The authors have previously shown that the spike (S) glycoprotein gene of MHV contains determinants of virulence, hepatitis, and demyelination. They then identified viruses containing mu... |
A novel methodology for large-scale phylogeny partition | Understanding the determinants of virus transmission is a fundamental step for effective design of screening and intervention strategies to control viral epidemics. Phylogenetic analysis can be a valid approach for the identification of transmission chains, and very-large data sets can be analysed through parallel comp... |
Advocacy, promotion and e-learning: Supercourse for zoonosis | This paper discusses the history of emerging infectious diseases, risk communication and perception, and the Supercourse lectures as means to strengthen the concepts and definition of risk management and global governance of zoonosis. The paper begins by outlining some of the key themes and issues in infectious disease... |
Pandemic Disease: A Past and Future Challenge to Governance in the United States | Throughout history, pandemics have posed significant challenges to governments. Examination of the ways that governments have responded to pandemics can contribute to the U.S. government's ability to react in the future. We utilize past cases of Severe Acute Respiratory Syndrome (SARS) and multiple forms of influenza t... |
Assessing Continuous Quality Improvement in Public Health: Adapting Lessons from Healthcare | CONTEXT: Evidence of the effect of continuous quality improvement (CQI) in public health and valid tools to judge that such effects are not fully formed. OBJECTIVE: The objective was to adapt and apply Shortell et al.'s (1998) four dimensions of CQI in an examination of a public health accountability and performance ma... |
Avian influenza aided readiness for swine flu | Despite gains from threat of bird flu, pandemic preparedness is patchy. |
Assessment of pathogenicity and tissue distribution of infectious bronchitis virus strains (Italy 02 genotype) isolated from moroccan broiler chickens | BACKGROUND: Avian infectious bronchitis (IB) is one of the most important viral diseases of poultry, affecting chickens of all ages and causing major economic losses in poultry flocks. Mass vaccination is conducted in Morocco using a vaccine against Massachusetts, which is the most dominant serotype; however no informa... |
Sharing public health data and information across borders: lessons from Southeast Asia | BACKGROUND: The importance of data and information sharing for the prevention and control of infectious diseases has long been recognised. In recent years, public health emergencies such as avian influenza, drug-resistant malaria, and Ebola have brought renewed attention to the need for effective communication channels... |
Lectins from the Edible Mushroom Agaricus bisporus and Their Therapeutic Potentials | The mushroom Agaricus bisporus secretes biologically active compounds and proteins with benefits for human health. Most reported proteins from A. bisporus are tyrosinases and lectins. Lectins are of therapeutic or pharmaceutical interest. To date, only limited information is available on A. bisporus lectins and lectin-... |
Forensic mental telehealth assessment (FMTA) in the context of COVID-19 | Due to the present COVID-19 pandemic, forensic mental telehealth assessment (FMTA) is an increasingly utilized means of conducting court-sanctioned psychiatric and psychological evaluations. FMTA is not a novel development, and studies have been published during the past two decades that opine on the positive and negat... |
Situation der Deutschen Universitätspathologien unter den Einschränkungen der Corona-Pandemie – Auswertung einer ersten repräsentativen Umfrage | German University Pathologies are affected by the Corona Pandemics and respective measures. A survey among all 36 University Pathologies was conducted (return rate 83%) and evaluated; it allows to assess the current situation and shows significant restrictions in the diagnostic and research performance and high willing... |
Chapter 15 Cord Blood Banking Operational and Regulatory Aspects | Abstract Umbilical cord blood (UCB) is an alternative source of hematopoietic stem cells for transplantation in patients with hematological malignancies, bone marrow failures, immunodeficiencies, and inherited metabolic disorders. In order to facilitate these transplants, large repositories of frozen UCB units collecte... |
A simple method for differentiating direct and indirect exposure to exhaled contaminants in mechanically ventilated rooms | Many airborne infectious diseases can be transmitted via exhaled contaminants transported in the air. Direct exposure occurs when the exhaled jet from the infected person directly enters the breathing zone of the target person. Indirect exposure occurs when the contaminants disperse in the room and are inhaled by the t... |
Pre-existing immunity to SARS-CoV-2: the knowns and unknowns | T cell reactivity against SARS-CoV-2 was observed in unexposed people; however, the source and clinical relevance of the reactivity remains unknown. It is speculated that this reflects T cell memory to circulating ‘common cold’ coronaviruses. It will be important to define specificities of these T cells and assess thei... |
Valor pronóstico de biomarcadores cardíacos en la enfermedad por COVID-19 | Resumen Introducción: en la enfermedad por COVID-19 se ha establecido que los pacientes con enfermedad cardiometabólica de base, tienen mayor riesgo de presentar desenlaces adversos. Esto ha incrementado el interés en estudiar variables cardiovasculares relevantes, para plantear su correlación con los desenlaces clínic... |
Prevention of EAE in non-human primates by a type IV phosphodiesterase inhibitor that suppresses tumor necrosis factor | |
Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden. | Abstract Background It is unclear whether asthma may affect susceptibility or severity of the Coronavirus Disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic. Objective To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease ... |
The Ebola Virus Disease Outbreak in West Africa: A Wake-up Call to Revitalize Implementation of the International Health Regulations | The 2014/15 Ebola virus disease (EVD) outbreak in West Africa has highlighted the inherent weaknesses associated with the implementation of the International Health Regulations (IHR). In this perspective article, the lessons learnt from the outbreak are used to review the challenges impeding effective implementation of... |
Core Minimal Datasets to Advance Clinical Research for Priority Epidemic Diseases | The Ebola virus disease outbreak in west Africa has prompted significant progress in responding to the clinical needs of patients affected by emerging infectious disease outbreaks. Among the noteworthy successes of vaccine trials, and the commendable efforts to implement clinical treatment trials during Ebola outbreaks... |
Replication and immune response in HAE of HCoV-HKU1 isolate from a pediatric patient with severe acute respiratory infection | |
Matrix metalloproteinase 3 as a valuable marker for patients with COVID‐19 | The situation of the coronavirus disease 2019 (COVID‐19) continues to evolve, our study explored the significance of serum levels of matrix metalloproteinase 3 (MMP3) as a marker for patients with COVID‐19. Sixty‐two COVID‐19 patients in the First Hospital of Hunan University of Chinese Medicine and Loudi Center for Di... |
Broad Spectrum Antiviral Agent Niclosamide and Its Therapeutic Potential | [Image: see text] The recent outbreak of coronavirus disease 2019 (COVID-19) highlights an urgent need for therapeutics. Through a series of drug repurposing screening campaigns, niclosamide, an FDA-approved anthelminthic drug, was found to be effective against various viral infections with nanomolar to micromolar pote... |
Discussies in crisistijd | |
Immunofluorescence Assay for Serologic Diagnosis of SARS | We evaluated a virus-infected cell-based indirect immunofluorescence assay for detecting anti–severe acute respiratory syndrome-associated coronavirus (SARS-CoV) immunoglobulin (Ig) G antibody. All confirmed SARS cases demonstrated seroconversion or fourfold rise in IgG antibody titer; no control was positive. Sensitiv... |
Repurposing old drugs as antiviral agents for coronaviruses | BACKGROUND: New therapeutic options to address the ongoing COVID-19 pandemic are urgently needed. One possible strategy is the repurposing of existing drugs approved for other indications as antiviral agents for SARS-CoV-2. Due to the commercial unavailability of SARS-CoV-2 drugs for treating COVID-19, we screened appr... |
COVID‐19 mortality in patients on anticoagulants and antiplatelet agents | Coagulopathy (Tang, et al 2020) and a prothrombotic diathesis with high D‐dimer and fibrinogen levels (Al‐Samkari, et al 2020) are associated with coronavirus disease 2019 (COVID‐19) caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). Extensive thrombosis in small vessels and the microvasculature in... |
Pain: A Potential New Label of COVID-19 | |
Promoting attachment between parents and neonates despite the COVID‐19 pandemic | Social distancing is the only option available during the COVID‐19 pandemic until a vaccine is developed. However, this is having a major impact on human relationships and bonding between parents and neonates is a major concern. Separation during this health emergency could have lifelong consequences for offspring and ... |
Cyclophilin A Associates with Enterovirus-71 Virus Capsid and Plays an Essential Role in Viral Infection as an Uncoating Regulator | Viruses utilize host factors for their efficient proliferation. By evaluating the inhibitory effects of compounds in our library, we identified inhibitors of cyclophilin A (CypA), a known immunosuppressor with peptidyl-prolyl cis-trans isomerase activity, can significantly attenuate EV71 proliferation. We demonstrated ... |
There are no best practices in a pandemic: Organ donation within the COVID‐19 epicenter | LiveOnNY, the organ procurement organization (OPO) for the greater New York metropolitan area, suspended several best practices to manage the rising referrals of deaths from hospitals during the SARS‐CoV‐2 pandemic. On April 2, 2020 hospitals in the donor service area were notified that COVID‐19 referrals should be def... |
Cutaneous manifestations in COVID‐19: Family cluster of Urticarial Rash | Coronavirus disease (COVID‐19) is rapidly spread across the world. Many clinical manifestations of the virus are described, and new symptoms are emerging, only few cases of patients with skin manifestation were described since the pandemic was announced by the WHO on March. Common clinical features of COVID‐19 reported... |
The role of airway macrophages in apoptotic cell clearance following acute and chronic lung inflammation | Acute and chronic inflammatory responses in the lung are associated with the accumulation of large quantities of immune and structural cells undergoing apoptosis, which need to be engulfed by phagocytes in a process called ‘efferocytosis’. Apoptotic cell recognition and removal from the lung is mediated predominantly b... |
A dynamic vaccination strategy to suppress the recurrent epidemic outbreaks | Abstract Efficient vaccination strategy is crucial for controlling recurrent epidemic spreading on networks. In this paper, based on the analysis of real epidemic data and simulations, it’s found that the risk indicator of recurrent epidemic outbreaks could be determined by the ratio of the epidemic infection rate of t... |
CSANZ Position Statement on the Evaluation of Patients Presenting With Suspected Acute Coronary Syndromes During the COVID-19 Pandemic # | Abstract A pandemic of Coronavirus-19 disease was declared by the World Health Organization on March 11, 2020. The pandemic is expected to place unprecedented demand on health service delivery. This position statement has been developed by the Cardiac Society of Australia and New Zealand to assist clinicians to continu... |
The philosophy of paediatric teaching: An interview with Dr Nikolaos Myriokefalitakis, former Clinical Director of the ‘Penteli’ Children's Hospital in Athens (Greece) | Dr Nikolaos Myriokefalitakis, one of the most experienced paediatricians in the city of Athens, Greece, has worked as a consultant paediatrician at the ‘P. & A. Kyriakou’ Children's Hospital for more than 25 years, while during the 2004–2011 period, he was the clinical director of the 1st Paediatric Department of the ‘... |
Clinical and CT features in pediatric patients with COVID‐19 infection: Different points from adults | PURPOSE: To discuss the different characteristics of clinical, laboratory, and chest computed tomography (CT) in pediatric patients from adults with 2019 novel coronavirus (COVID‐19) infection. METHODS: The clinical, laboratory, and chest CT features of 20 pediatric inpatients with COVID‐19 infection confirmed by phary... |
La Obesidad y el coronavirus 2019-nCoV. Una relación de riesgo | |
Response to the commentary by Pisoni E. and Van Dingenen R. on ‘Assessing nitrogen dioxide (NO(2)) levels as a contributing factor to coronavirus (COVID-19) fatality’ | |
Response to the COVID-19 Epidemic: The Chinese Experience and Implications for Other Countries | The ongoing outbreak of the novel coronavirus disease (COVID-19) that occurred in China is rapidly spreading globally. China’s bond and strict containment measures have been proved (in practice) to significantly reduce the spread of the epidemic. This was obtained through the use of emergency control measures in the ep... |
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