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5c80d2836428f9a32ee6cae4bc45e3536d037d90
there is no character for the dele symbol
there is no character for the dele symbol in unicode as of version 15.0 from september 2022, although its addition has been proposed. the visually similar character for pfennig at u+20b0 ₰ german penny sign from the currency symbols block is often used to represent a dele in unicode. the same unicode character is also ...
wikipedia
2d0dcfd40063965af575d8eaf84fa4795ec090ab
the origin of the symbol appears to be
the origin of the symbol appears to be an archaic letter d in the kurrent script, as an abbreviation for dele or deleatur. it is markedly similar (if not identical in some cases) to the symbol for the german penny () which is an archaic lowercase d, for denarius. as with most hand-written letters and symbols, its appea...
wikipedia
fb79765ab2acae011ceae7f95a451f72fffb2f8e
dele, the more common term in modern american
dele, the more common term in modern american english (sometimes used as a verb, e.g. "dele that graf "), coincides with the imperative form of the latin delere ("to delete"). however, the oxford english dictionary notes an earlier use in english of deleatur (latin "let it be deleted"), and suggests that dele in englis...
wikipedia
d5df6ec6133a29bdd1a0bf5fd9744beeb1c0458d
a dele or deleatur (/ ˈ d iː
a dele or deleatur (/ ˈ d iː l iː /, / ˌ d iː l iː ˈ eɪ t ər /) is an obelism (a proofreading symbol) used to mark something for deletion.
wikipedia
da25e92d44baf5fa3226562177419488e13332c7
he started his career as oil and gas
he started his career as oil and gas extraction operator on deep offshore platform-5 of “28 of may” oil and gas extraction department (oged) in 1991. he worked in the capacity of operator, engineer, deputy chief and then chief of primary gas preparation and transportation facility up to 1999. from 1997–2007, he worked ...
wikipedia
39567c3e6a9848c8db078db79d8e568820b05a15
dashgin iskandarov was born in azerbaijan's shemakhi district
dashgin iskandarov was born in azerbaijan's shemakhi district in 1965. he did his military service from 1983–1985, and after completing his military service, he entered the department for development and complex mechanization of oil and gas fields of azerbaijan institute of oil and chemistry named m. azizbayov (now aze...
wikipedia
0971b0cc35004e438356dbed59b0e8c8229e766b
double copy theory is a theory in theoretical
double copy theory is a theory in theoretical physics, specifically in quantum gravity, that hypothesizes a perturbative duality between gauge theory and gravity. the theory says that scattering amplitudes in non-abelian gauge theories can be factorized such that replacement of the color factor by additional kinematic ...
wikipedia
890df2316f8b068bcf60acde6fd0c65e08d48c99
the theory can be used to make calculations
the theory can be used to make calculations of gravity scattering amplitudes simpler by instead calculating the yang–mills amplitude and following the double copy prescription. this technique has been used, for example, to calculate the shape of gravitational waves emitted by two merging black hole. this was proven to ...
wikipedia
b2d40138f9a589ebdf58be722a0241809a645b34
double copy theory is a theory in theoretical
double copy theory is a theory in theoretical physics, specifically in quantum gravity, that hypothesizes a perturbative duality between gauge theory and gravity. the theory says that scattering amplitudes in non-abelian gauge theories can be factorized such that replacement of the color factor by additional kinematic ...
wikipedia
b74fa02a0c341eb7c9356a1524640ef9bb17b021
delegation theory in its broadest sense is the
delegation theory in its broadest sense is the process by which an authority shifts some of its responsibilities onto another entity with the view of achieving the best performance in terms of its stated aims and purposes. it is very common for government agencies to delegate authority to private companies with the nec...
wikipedia
623fc98fc6a8faefaea06961e3db9d8c71085bcc
the three basque delegations (and previously also the
the three basque delegations (and previously also the delegation of navarre) are known by the term delegaciones forales, since these four territories still preserve their fueros or medieval privileges. the delegación foral is an executive branch that depends on the general meetings (the legislative). the general meetin...
wikipedia
315bc9b188e67738b4c6e22b32d5634f04574857
the members of the delegations are elected in
the members of the delegations are elected in an indirect way, by computing the total result of local elections in each province. however, the members of the town halls and insular councils always have been chosen in direct election, in elections separated from the autonomic or joint with the autonomic elections in the...
wikipedia
bdabf670dda601c1350187e1a42af138468fcf93
the history of the delegations traces back to
the history of the delegations traces back to 1812 with the enactment of the constitution of cadiz, the first democratic constitution in spain, having had different roles over the centuries, such as tight control from central government in francoist spain.
wikipedia
e401897ef0cad4bdd813ea7dc1ce1827da703a2a
the delegations (in aragonese deputazions, in catalan diputacions,
the delegations (in aragonese deputazions, in catalan diputacions, in basque aldundia and in galician deputación) have territorial character and their function is to manage the economic and administrative interests of the provinces. in the canary islands the functions of the delegations are exerted by each island's tow...
wikipedia
1850ea74ed4d29ca6abe0677ea69f5abdbdcdcad
a delegation (of latin deputatione) is, in a
a delegation (of latin deputatione) is, in a broad sense, a body of deputies of an assembly (persons to which the assembly delegates its authority) and its respective activities. in spain, the term is used in a stricter sense in order to designate the administration of some provinces on behalf of the central authority,...
wikipedia
dabfad41c9a66e18076baaf53ac7af443b04c86f
in contrast giandomenico majone has formulated a theory
in contrast giandomenico majone has formulated a theory of delegation which stresses the importance of credibility problems in the decision to delegate to european institutions. not only is this explained as a mechanism to ensure member states comply with treaty obligations, but employing similar logic as that used in ...
wikipedia
a3844152116ce1171ce136aaec3eb81e85f199cd
andrew moravcsik is perhaps the most prominent intergovernmentalist
andrew moravcsik is perhaps the most prominent intergovernmentalist theorist who has written on delegation and his work can essentially be thought of as applying the principal-agent model in a manner which stresses minimal agency loss. the model is not a simple principal-agent model however, as he conceives of the eu a...
wikipedia
795193b71ffa257baf3917c3a767c1fc5be9becd
delegation theories have also been applied extensively in
delegation theories have also been applied extensively in studies of the european union. the dominant approach has undoubtedly been the principal-agent approach, but there have also been variations from the classic form by intergovernmentalist approaches and the fiduciary model laid out by giandomenico majone.
wikipedia
e6476a61a4926cbbdffbfd5ed345c2127e36991a
this argument has been highly influential and the
this argument has been highly influential and the number of icbs has risen dramatically since the 1980s however it is not without its critics. many scholars (for instance kathleen mcnamara) have questioned the premises of the icb argument, making the case that democratic pressures will not result in high inflation and ...
wikipedia
fa13913300fdd3afc8118a216ec6f51ffd24f379
one of the most important areas where delegation
one of the most important areas where delegation theories have been applied has been in the debate over the merits of independent central banks (icbs) such as the bank of england or the european central bank. this debate has corresponded to the theories of credible commitments and can be understood as a solution to pro...
wikipedia
b74fa02a0c341eb7c9356a1524640ef9bb17b021
delegation theory in its broadest sense is the
delegation theory in its broadest sense is the process by which an authority shifts some of its responsibilities onto another entity with the view of achieving the best performance in terms of its stated aims and purposes. it is very common for government agencies to delegate authority to private companies with the nec...
wikipedia
85137362ac11030d680ce50e883f07b4d2638d35
elvin abraham kabat was an american biomedical scientist
elvin abraham kabat was an american biomedical scientist and one of the founding fathers of quantitative immunochemistry. kabat was awarded the louisa gross horwitz prize from columbia university in 1977, national medal of science in 1991, and american association of immunologists lifetime achievement award in 1995. he...
wikipedia
1d6fc6a1d7d4e486b798ea81a8d036681c55f194
in 1942, kabat married sally lennick, a young
in 1942, kabat married sally lennick, a young canadian art student. they had three children, one of whom is the american developer of mindfulness-based stress reduction (mbsr), jon kabat-zinn. since 2001, the families of michael heidelberger and kabat have worked with columbia university's department of microbiology an...
wikipedia
0cec7c4a119029c0fad1fc5ea18f3fd0e7dea97d
after being selected by the national institutes of
after being selected by the national institutes of health as a fogarty scholar in 1974, kabat continued to conduct government research alongside his teaching at columbia university well after his 1985 emeritus appointment, maintaining a working research laboratory and remaining an active member of the department of mic...
wikipedia
057e95e827f3dd25cbc955d572d2cbfded555002
following president harry s. truman 's 1947 executive
following president harry s. truman 's 1947 executive order 9835 mandating loyal screenings of all federal employees, kabat was reported by swedish biochemist james b. sumner for supposedly being a communist sympathizer. kabat was dismissed from his research position at the bronx veterans administration hospital, inter...
wikipedia
73ee019dfbbae703232545b802824df4818505dd
kabat spent the majority of his career as
kabat spent the majority of his career as a faculty member of the columbia university college of physicians and surgeons. hired as a research associate by the department of biochemistry in 1941, he joined the faculty of the department of bacteriology as an assistant professor in 1946. kabat became an associate professo...
wikipedia
b551773a508e2d4df29a80f76f1acaad4467123d
as part of a post-doctoral fellowship funded by
as part of a post-doctoral fellowship funded by the rockefeller foundation, kabat studied new methods of ultracentrifugation and electrophoresis alongside arne tiselius and kai pederson in theodor svedberg 's uppsala university lab in sweden to research immunoglobulin g (igg). in 1938, he returned to new york city to t...
wikipedia
4cc42183078420f622936ffbfd164d04da653094
in january 1933, kabat began working in michael
in january 1933, kabat began working in michael heidelberger's laboratory by conducting routine lab chores at the columbia university college of physicians and surgeons, introduced through heidelberger's wife nina, a customer of the kabat family's dress business. kabat started work on his ph.d. in the department of bio...
wikipedia
baf143063c4c185a7a576204e114421467273fe0
kabat's parents arrived in the united states from
kabat's parents arrived in the united states from eastern europe toward the end of the 19th century, changing their last name from kabatchnick to kabat. the bankruptcy of his family's dress manufacturing business during the great depression led to kabat's life-long miserly attitudes toward personal and laboratory expen...
wikipedia
20943c146ff1ec975453b55ed7edced569a7cb6a
during his career, kabat served on advisory panels
during his career, kabat served on advisory panels for the national research council, office of naval research, national science foundation, national multiple sclerosis society, american foundation for allergic diseases, new york blood center, roche institute of molecular biology, institute of cancer research, and gorg...
wikipedia
edddee778582142a7fe0797f6a42656613827463
kabat is best known for discovering the structural
kabat is best known for discovering the structural and genetic basis for the specificity of antibodies. after showing that antibodies are gamma globulins, he used oligosaccharides of different lengths to interfere with antibodies attempting to bind to the blood plasma substitute dextran, accurately estimating the size ...
wikipedia
c8910d28c8f93fb99aa1793c267fc5ac96f412e5
while working under michael heidelberger at the columbia
while working under michael heidelberger at the columbia university college of physicians and surgeons, kabat studied the carbohydrate chemistry of embryonic-state-specific antigens and markers of white blood cells. additionally, he discovered the chemical basis of the abo blood group system.
wikipedia
4e900039da4b8ee156dfaa0b9951e8aa4936517c
elvin a. kabat was the president of the
elvin a. kabat was the president of the american association of immunologists from 1965 to 1966, a member of the national academy of sciences, and a fellow of the american academy of arts and sciences. he designed the eponymous kabat numbering scheme for numbering amino acid residues in antibodies based on their variab...
wikipedia
c4b3b8f7cb2a6b73e17ebed9aba242df85e12749
elvin abraham kabat (september 1, 1914 – june
elvin abraham kabat (september 1, 1914 – june 16, 2000) was an american biomedical scientist and one of the founding fathers of quantitative immunochemistry. kabat was awarded the louisa gross horwitz prize from columbia university in 1977, national medal of science in 1991, and american association of immunologists li...
wikipedia
0f8228b2fc31668a7e559998e9b9bab8f89953b2
martin played for stoke city before joining local
martin played for stoke city before joining local rivals port vale on trial in july 1976. he appeared as a substitute in a 1–0 defeat at wrexham in a first round league cup match on 18 august 1976. he was not selected again and was instead released in september 1976. he later worked as a matchday ambassador at vale par...
wikipedia
87d7d24e983140ed399122a2bb2eadcefd06f1c7
debbie pain is a conservation biologist and ecotoxicologist
debbie pain is a conservation biologist and ecotoxicologist working on endangered birds around the world. since 1988 she has led projects into reversing the decline in several species through research, practical and policy measures at the royal society for the protection of birds and wildlife and wetlands trust.
wikipedia
048d1aa3904def4eeab669843181923b259fcf1d
pain became keen on birds at the age
pain became keen on birds at the age of seven, inspired by a teacher while at junior school in her home town of ramsgate. she was first in her family to go to university and studied environmental chemistry at wye college, university of london followed by research into the biochemistry of lead poisoning from ammunition ...
wikipedia
45d85622d5efffd627369e4f76456604a6894e91
during her time with the wwt she increased
during her time with the wwt she increased its role in international conservation. this included multinational programmes for recovery of the critically endangered spoon-billed sandpiper and the madagascar pochard. she also continued her research and policy work to reduce lead poisoning of wild birds from ammunition so...
wikipedia
ec36b8b22de5368c7b6e8f85f82c07c2b8a99f7f
while with the rspb she was their first
while with the rspb she was their first international research biologist and then formed and managed an international research team that collaborated within birdlife. she led projects in the early 2000s into causes of decline in the numbers of white-backed and indian vultures in india. she also led research into the ef...
wikipedia
5e6c3192e04eb63b43713c1cadd83f0b7fff70a7
pain worked from 1988 on ecotoxicology at station
pain worked from 1988 on ecotoxicology at station biologique de la tour du valat in the camargue, france, and from 1992 was employed in the research department of the royal society for the protection of birds. she initiated and led the international research section. in 2008 she became director of conservation for the ...
wikipedia
87d7d24e983140ed399122a2bb2eadcefd06f1c7
debbie pain is a conservation biologist and ecotoxicologist
debbie pain is a conservation biologist and ecotoxicologist working on endangered birds around the world. since 1988 she has led projects into reversing the decline in several species through research, practical and policy measures at the royal society for the protection of birds and wildlife and wetlands trust.
wikipedia
ecccf6d5fb7ca4786ba81a64a35b95c0a8852e69
in enzymology, an ethanolaminephosphotransferase is an enzyme that
in enzymology, an ethanolaminephosphotransferase is an enzyme that catalyzes the chemical reaction thus, the two substrates of this enzyme are cdp-ethanolamine and 1,2-diacylglycerol, whereas its two products are cmp and phosphatidylethanolamine. this enzyme belongs to the family of transferases, specifically those tra...
wikipedia
fe73557822ac02b42dddb57c30a37d254fe1c2b9
this enzyme belongs to the family of transferases,
this enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. the systematic name of this enzyme class is cdp-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase. other names in common use include ept, diacylglycerol ethanolaminephosphotransfera...
wikipedia
a3fee07824490cabd30c58608fc0f0088aa90c01
this is a list of participation by football
this is a list of participation by football clubs in the cayman islands in north american competitions. in 1981, yama sun oil became the first caymanian football club to participate in a concacaf competition, entering in the caribbean zone of the 1981 concacaf champions' cup. they advanced to the second qualifying roun...
wikipedia
c13849a9af22bff42590e3148c37833c5e0c0be9
in 1981, yama sun oil became the first
in 1981, yama sun oil became the first caymanian football club to participate in a concacaf competition, entering in the caribbean zone of the 1981 concacaf champions' cup. they advanced to the second qualifying round before losing to subt of present-day curaçao.
wikipedia
b41a5a5a8dfc7f532a63fa601a62f26bd5331751
the dicastery for promoting integral human development is
the dicastery for promoting integral human development is a dicastery of the roman curia. the vatican announced the creation of the dicastery on 31 august 2016 and it became effective 1 january 2017. cardinal peter turkson was named its first prefect. the prefect is to be assisted by a secretary and at least one unders...
wikipedia
090557f17af9aa9fb774d440cca9fff802a75892
the dicastery for promoting integral human development is
the dicastery for promoting integral human development is committed to fostering among peoples: sensitivity for peace, commitment to justice and solidarity with those who are most vulnerable such as migrants and refugees, particularly through the celebrations of the world day of peace, the world day of migrants, the wo...
wikipedia
c1ba7d7cf4762bc591fbbc979a2042b512cee37f
in fulfilling its mission, it may establish relationships
in fulfilling its mission, it may establish relationships with associations, institutes and non-governmental organizations, including those outside the catholic church, who are committed to promoting justice and peace. it may also enter into discussion with representatives of civil governments and other international p...
wikipedia
564e6713f443575ca1a7c3a75a3cfd56d466bd01
the dicastery promotes integral human development in the
the dicastery promotes integral human development in the light of the gospel and in the tradition of the church's social teachings. to this end, it maintains relations with the conferences of bishops, offering them its cooperation so that values related to justice and peace as well as the care of creation may be promot...
wikipedia
83101bb1513d9f0b0d4cda9f81e225caddcf7af8
on 20 march 2020, pope francis asked the
on 20 march 2020, pope francis asked the dicastery for promoting integral human development (dpihd) to create a vatican covid-19 commission to express the church's solicitude facing the covid-19 pandemic, and propose responses to the potential socio-economic challenges deriving from it.
wikipedia
de88de6c9ecbbf0c9ba4f3937f10fb8fcf54030c
the pope announced that "temporarily" he would personally
the pope announced that "temporarily" he would personally direct the special migrants and refugees section which is part of the dicastery. he named the canadian jesuit michael czerny (later cardinal) and the italian scalabrinian fabio baggio to serve as undersecretaries for issues related to refugees and migrants.
wikipedia
f6a33dc895dca38d367df8a31dfc81893300b2ce
on 16 june 2017 the pope named bruno
on 16 june 2017 the pope named bruno marie duffé, a french professor with long experience in human rights and relief work, the dicastery's secretary. fr. nicola riccardi and msgr. segundo tejado muñoz were named undersecretaries, on 8 july 2017.
wikipedia
cd04033738921138b672dcc1d28667ca49489b8d
this dicastery of the roman curia combined the
this dicastery of the roman curia combined the work of four pontifical councils established following the second vatican council: justice and peace, pastoral care of migrants and itinerant people, pastoral assistance to health care workers, and cor unum. pope francis has given it responsibility for "issues regarding mi...
wikipedia
eedf894a73ce9d469d21fc021bd418c7b2968061
on 21 december 2021, members of the dicastery's
on 21 december 2021, members of the dicastery's leadership submitted their resignations in anticipation of the end of their five-year mandate in january. pope francis accepted them. on 23 december 2021, pope francis named cardinal michael czerny and sister alessandra smerilli interim prefect and secretary, respectively...
wikipedia
14dcb2eca86cdbdc4697ce4d0584723219c1e19a
the vatican announced the creation of the dicastery
the vatican announced the creation of the dicastery on 31 august 2016 and it became effective 1 january 2017. cardinal peter turkson was named its first prefect. the prefect is to be assisted by a secretary and at least one undersecretary.
wikipedia
904f31a088ae4a2623c2582365fb798c63144c76
the esa optical ground station is the european
the esa optical ground station is the european space agency's ground based observatory at the teide observatory on tenerife, spain, built for the observation of space debris. ogs is part of the artemis experiment and is operated by the iac and ataman science s.l.u. the observatory is a 1-meter coudé telescope with a fi...
wikipedia
48529fd6b343c2f21d59333183682a6f9b905fac
to make scientific astronomical night observations. it is
to make scientific astronomical night observations. it is equipped with a cryogenically cooled mosaic ccd-camera of 4k×4k pixels. the detection threshold is between 19th and 21st magnitude, which corresponds to a capability to detect space debris objects as small as 10 cm in the geostationary ring. as a large part of t...
wikipedia
b139e11f597e2837d692dd6737298f83de50f9fc
since 2006, the telescope has also been used
since 2006, the telescope has also been used as a receiver station for quantum communication experiments (such as testing bell's inequality, quantum cryptography, and quantum teleportation), with the sender station being 143 km away in the observatory on la palma. this is possible because this telescope can be tilted t...
wikipedia
c304426b18c55fc2d663e20b9815b57aa6a91929
it is equipped with a cryogenically cooled mosaic
it is equipped with a cryogenically cooled mosaic ccd-camera of 4k×4k pixels. the detection threshold is between 19th and 21st magnitude, which corresponds to a capability to detect space debris objects as small as 10 cm in the geostationary ring. as a large part of the observation time is dedicated to space debris sur...
wikipedia
781a9525ad5c3e2a766e53b51058e367f97db7e0
the observatory is a 1-meter coudé telescope with
the observatory is a 1-meter coudé telescope with a field of view of 0.7 degrees, supported by an english cross-axial mount inside a dome 12.5-meters in diameter. its main purposes are:
wikipedia
210f1f74be055142d299296c4b7377dc2d1e1110
the esa optical ground station (ogs telescope or
the esa optical ground station (ogs telescope or esa space debris telescope) is the european space agency 's ground based observatory at the teide observatory on tenerife, spain, built for the observation of space debris. ogs is part of the artemis experiment and is operated by the iac (instituto de astrofísica de cana...
wikipedia
7fd5e7dc1c58efb78018f1dfe11cad01e974c775
the endoneurium is a layer of delicate connective
the endoneurium is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber in the peripheral nervous system. its component cells are called endoneurial cells. the endoneuria with their enclosed nerve fibers are bundled into groups called nerve fascicles, each fascicle within its ow...
wikipedia
4a5a452b58a7e3e104a955713d6bd9e4b499b82c
the endoneurium runs longitudinally along the nerve fiber,
the endoneurium runs longitudinally along the nerve fiber, but with discontinuities where septa pass inward from the innermost layer of the perineurium. it contains fine bundles of fibrous connective tissue, primarily collagen, embedded in a matrix of ground substance. this structure serves to support capillary blood v...
wikipedia
e00a9489703892d91c1907eff62453cb607a7f36
the endoneurium contains a liquid known as endoneurial
the endoneurium contains a liquid known as endoneurial fluid, which contains little protein. in the peripheral nervous system the endoneurial fluid is notionally equivalent to cerebrospinal fluid in the central nervous system. peripheral nerve injuries commonly release increased amounts of endoneurial fluid into surrou...
wikipedia
8caaff725f07c2cd80f14f0018c21ed01badb9d3
the endoneurium (also called endoneurial channel, endoneurial sheath,
the endoneurium (also called endoneurial channel, endoneurial sheath, endoneurial tube, or henle's sheath) is a layer of delicate connective tissue around the myelin sheath of each myelinated nerve fiber in the peripheral nervous system. its component cells are called endoneurial cells. the endoneuria with their enclos...
wikipedia
8da03c0b136ea54be3ddafa9093a6d92eee215ad
cationic liposomes are spherical structures that contain positively
cationic liposomes are spherical structures that contain positively charged lipids. cationic liposomes can vary in size between 40 nm and 500 nm, and they can either have one lipid bilayer (monolamellar) or multiple lipid bilayers (multilamellar). the positive charge of the phospholipids allows cationic liposomes to fo...
wikipedia
1a82935e47202158650e3d8a834faa5e801c3cb3
if delivered through intravenous administration, cationic liposomes can
if delivered through intravenous administration, cationic liposomes can result in opsonization, which is an immune response that occurs when opsonins tag foreign pathogens to be eliminated through phagocytosis. due to their positive charge, cationic liposomes bind to various plasma proteins, forming a protein corona on...
wikipedia
4b5869d6af2e0838584fe4c9a5832629d87d4c12
the positive charge of cationic lipids has been
the positive charge of cationic lipids has been shown to have cytotoxic effects, as these lipids can activate several pro-apoptotic and pro-inflammatory cell signaling pathways. the cationic nature of these lipids is associated with the structure of the head group. in particular, it was found that the quaternary ammoni...
wikipedia
7352db8b9ef9888f1dade03d3f6047cb88912d0b
syncore bio's endotag-1 is a cationic liposome formulation
syncore bio's endotag-1 is a cationic liposome formulation with embedded ptx. the cationic lipid used in this formulation is dioleoyloxypropyltrimethylammonium (dotap). the ptx-embedded cationic liposome interacts with the negatively charged tumor endothelial cells required for tumor angiogenesis, in order to reduce th...
wikipedia
1c50e1a88d294738d4fd0327b53041e71eb58f7f
paclitaxel (ptx) is a chemotherapy medication used to
paclitaxel (ptx) is a chemotherapy medication used to treat many types of cancer, such as ovarian cancer, breast cancer, and pancreatic cancer. ptx works by inhibiting the growth of tumor endothelial cells, however it has in vivo delivery issues that are caused by its unfavorable pharmacokinetic and physical properties...
wikipedia
b98cbb8a9d8b03e1d9e51dd385d139b54eb8d2dc
cationic liposomes can deliver nucleic acids into the
cationic liposomes can deliver nucleic acids into the cell through an endocytotic pathway or through cell membrane fusion. fusogenic cationic liposomes almost exclusively deliver nucleic acids through cell membrane fusion. the fusion between positively charged cationic liposomes and negatively charged cell surfaces eff...
wikipedia
d31d496f051679e5a2f78400c162580058720ab5
cationic liposomes are manufactured similarly to liposomes. there
cationic liposomes are manufactured similarly to liposomes. there are multiple processes that can be used to form cationic liposomes, such as sonication, extrusion, and vortexing. however, the shear forces associated with these methods are capable of damaging the nucleic acids prior to encapsulation. microfluidics is a...
wikipedia
c83a98824b20c3b0f9dd53e8122328aac03b40d5
because the phospholipids each have a hydrophobic tail
because the phospholipids each have a hydrophobic tail and a hydrophilic head group, they are able to form a lipid bilayer with the hydrophilic heads facing outwards and the hydrophobic tails facing inwards. adding dope in addition to dotma promotes the endosomal escape of nucleic acids into the cytosol when the cation...
wikipedia
9dc16936468a8760f5ddda07a548774e5ea4309f
cationic liposomes with a higher transfection efficiency are
cationic liposomes with a higher transfection efficiency are composed of a cationic phospholipid, and a few neutral helper lipids. a commonly used cationic phospholipid is dotma, and a commonly used fusogenic helper lipid is dioleoyl phosphatidylethanolamine (dope). a couple of commonly used neutral helper lipids are c...
wikipedia
2c018d53172b7003799f3e07b6ea5942aaa19def
the use of cationic lipids helps to enhance
the use of cationic lipids helps to enhance the overall stability and efficiency of liposomes. although cationic lipids themselves are able to encapsulate nucleic acids into liposomes, the transfection efficiency is low due to a process known as endosomal escape. lipids that are capable of destabilizing endosomal membr...
wikipedia
1ff973adfa1906fc1e93155325e74c8b49c2f3e7
in the 1960s, alec d. bangham discovered liposomes
in the 1960s, alec d. bangham discovered liposomes as concentric lipid bilayers surrounding an aqueous center, based on his research at the university of cambridge babraham institute. the first formulations were designed using all natural lipids. in 1987, philip felgner published the first approach to using cationic li...
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4f2e2d18fa667e412d09e764e51644614a43925d
cationic liposomes are spherical structures that contain positively
cationic liposomes are spherical structures that contain positively charged lipids. cationic liposomes can vary in size between 40 nm and 500 nm, and they can either have one lipid bilayer (monolamellar) or multiple lipid bilayers (multilamellar). the positive charge of the phospholipids allows cationic liposomes to fo...
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09fdb58002ade196c1d8f41c4376106001e29f0f
database encryption can generally be defined as a
database encryption can generally be defined as a process that uses an algorithm to transform data stored in a database into "cipher text" that is incomprehensible without first being decrypted. it can therefore be said that the purpose of database encryption is to protect the data stored in a database from being acces...
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bdc6470edd0cffba4d395e78665a45c4a6ba918f
when discussing the topic of database encryption it
when discussing the topic of database encryption it is imperative to be aware of the risks that are involved in the process. the first set of risks are related to key management. if private keys are not managed in an "isolated system", system administrators with malicious intentions may have the ability to decrypt sens...
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0e5f9713205e92f55310fb927b7dbbad9662fef6
the first important disadvantage of application-level encryption is
the first important disadvantage of application-level encryption is that applications used by a firm will need to be modified to encrypt data themselves. this has the potential to consume a significant amount of time and other resources. given the nature of opportunity cost firms may not believe that application-level ...
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6c6a152f4bb58a9d5fc679debe691e58cc61a39e
one of the most important advantages of application-level
one of the most important advantages of application-level encryption is the fact that application-level encryption has the potential to simplify the encryption process used by a company. if an application encrypts the data that it writes/modifies from a database then a secondary encryption tool will not need to be inte...
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97707df1acf26cb82c0aae599c1ec15ede8eff08
in application-level encryption, the process of encrypting data
in application-level encryption, the process of encrypting data is completed by the application that has been used to generate or modify the data that is to be encrypted. essentially this means that data is encrypted before it is written to the database. this unique approach to encryption allows for the encryption proc...
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5425dc4dd51416b6b35c98e0c14d6e4a09278a76
some systems incorporate a "pepper" in addition to
some systems incorporate a "pepper" in addition to salts in their hashing systems. pepper systems are controversial, however it is still necessary to explain their use. a pepper is a value that is added to a hashed password that has been salted. this pepper is often unique to one website or service, and it is important...
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c2c1d3dcea810fc6337ccb6c3855fc54579d6f12
one issue that arises when using hashing for
one issue that arises when using hashing for password management in the context of database encryption is the fact that a malicious user could potentially use an input to hash table rainbow table for the specific hashing algorithm that the system uses. this would effectively allow the individual to decrypt the hash and...
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a800a8338290d3662d2a74e7e7b9c45271053673
hashing is used in database systems as a
hashing is used in database systems as a method to protect sensitive data such as passwords; however it is also used to improve the efficiency of database referencing. inputted data is manipulated by a hashing algorithm. the hashing algorithm converts the inputted data into a string of fixed length that can then be sto...
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c360c22df2c122a1e161acab5f3cae26f6ed6190
the symmetric & asymmetric database encryption section introduced
the symmetric & asymmetric database encryption section introduced the concept of public and private keys with basic examples in which users exchange keys. the act of exchanging keys becomes impractical from a logistical point of view, when many different individuals need to communicate with each-other. in database encr...
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4953c0b55edb08e1d173aed3fd784f6f90bba7f5
asymmetric encryption expands on symmetric encryption by incorporating
asymmetric encryption expands on symmetric encryption by incorporating two different types of keys into the encryption method: private and public keys. a public key can be accessed by anyone and is unique to one user whereas a private key is a secret key that is unique to and only known by one user. in most scenarios t...
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b9330cba894e5b9aacec8ee6c117027f5b80f95c
symmetric encryption in the context of database encryption
symmetric encryption in the context of database encryption involves a private key being applied to data that is stored and called from a database. this private key alters the data in a way that causes it to be unreadable without first being decrypted. data is encrypted when saved, and decrypted when opened given that t...
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94b15ab05aa5ae490fb18bd8e1dd25b95b24a276
it is important to note that traditional database
it is important to note that traditional database encryption techniques normally encrypt and decrypt the contents of a database. databases are managed by "database management systems" (dbms) that run on top of an existing operating system (os). this raises a potential security concern, as an encrypted database may be r...
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1be93a733b857e21031fe21371e50acf39cc3342
experimental work is being done on providing database
experimental work is being done on providing database operations (like searching or arithmetical operations) on encrypted fields without the need to decrypt them. strong encryption is required to be randomized - a different result must be generated each time. this is known as probabilistic encryption. field-level encry...
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2279bbe551e613ee11ce6744005ab00fb4a5d6c7
in order to explain column-level encryption it is
in order to explain column-level encryption it is important to outline basic database structure. a typical relational database is divided into tables that are divided into columns that each have rows of data. whilst tde usually encrypts an entire database, column-level encryption allows for individual columns within a ...
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5f7967f843de36e33eff6f8a89600589c5488cb2
transparent data encryption (often abbreviated as tde) is
transparent data encryption (often abbreviated as tde) is used to encrypt an entire database, which therefore involves encrypting " data at rest ". data at rest can generally be defined as "inactive" data that is not currently being edited or pushed across a network. as an example, a text file stored on a computer is "...
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3cb03d0c426b140febbcbb9add48d800918ebb8a
database encryption can generally be defined as a
database encryption can generally be defined as a process that uses an algorithm to transform data stored in a database into " cipher text " that is incomprehensible without first being decrypted. it can therefore be said that the purpose of database encryption is to protect the data stored in a database from being acc...
wikipedia
717a0918b290dfb7d27986330872c5a6de3ec936
in mathematics, the cartan–hadamard conjecture is a fundamental
in mathematics, the cartan–hadamard conjecture is a fundamental problem in riemannian geometry and geometric measure theory which states that the classical isoperimetric inequality may be generalized to spaces of nonpositive sectional curvature, known as cartan–hadamard manifolds. the conjecture, which is named after f...
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82fedd59a3bc07d3a175c17ad10fb10e5d7a6b75
the generalized conjecture has been established only in
the generalized conjecture has been established only in dimension 2 by gerrit bol, and dimension 3 by kleiner. the generalized conjecture also holds for regions of small volume in all dimensions, as proved by frank morgan and david johnson.
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0404d1561007f644dcfb83d5893a9163e490366c
the conjecture has a more general form, sometimes
the conjecture has a more general form, sometimes called the "generalized cartan–hadamard conjecture" which states that if the curvature of the ambient cartan–hadamard manifold m is bounded above by a nonpositive constant k, then the least perimeter enclosures in m, for any given volume, cannot have smaller perimeter t...
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10dd1af9c80308af805b05a5c2b2f6c235bd5edb
weil's proof relies on conformal maps and harmonic
weil's proof relies on conformal maps and harmonic analysis, croke's proof is based on an inequality of santaló in integral geometry, while kleiner adopts a variational approach which reduces the problem to an estimate for total curvature. mohammad ghomi and joel spruck have shown that kleiner's approach will work in a...
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ebeb1d0846e1cda0709c715590ab2e86b1824928
according to marcel berger, weil, who was a
according to marcel berger, weil, who was a student of hadamard at the time, was prompted to work on this problem due to "a question asked during or after a hadamard seminar at the collège de france " by the probability theorist paul lévy.
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dd9abb24e741c158c372cc048414e67ae113d731
the conjecture, in all dimensions, was first stated
the conjecture, in all dimensions, was first stated explicitly in 1976 by thierry aubin, and a few years later by misha gromov, yuri burago and viktor zalgaller. in dimension 2 this fact had already been established in 1926 by andré weil and rediscovered in 1933 by beckenbach and rado. in dimensions 3 and 4 the conject...
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5acc8e9f49d7a4dd7e26b7e0a53312de026e60dd
informally, the conjecture states that negative curvature allows
informally, the conjecture states that negative curvature allows regions with a given perimeter to hold more volume. this phenomenon manifests itself in nature through corrugations on coral reefs, or ripples on a petunia flower, which form some of the simplest examples of non-positively curved spaces.
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