IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q13153 | P19086 | 1 | phosphorylation | up-regulates | 0.2 | Phosphorylation of either ser(16) by pak1 or ser(27) by pkc decreased the affinity of galpha(z) for gbetagamma;phosphorylation of both residues by pkc caused no further effect. Pak1 thus regulates galpha(z) function by attenuating the inhibitory effects of both gaps and gbetagamma. | SIGNOR-48673 |
O15534 | Q92973 | 0 | relocalization | up-regulates activity | 0.268 | The non-classical nuclear import carrier Transportin 1 modulates circadian rhythms through its effect on PER1 nuclear localization | SIGNOR-262102 |
O15217 | P0DMV9 | 0 | relocalization | up-regulates activity | 0.2 | Model showing Ser189/Thr193 protein kinase dependent phosphorylation of GST A4‐4 has increased affinity for chaperone Hsp70 which activates mitochondrial competent import signals for GSTA4‐4. |Protein kinase A mediated phosphorylation of serine residues of CYPs increases the affinity of proteins for binding to cytoplas... | SIGNOR-264800 |
O15392 | P98170 | 2 | binding | up-regulates | 0.494 | Formation of a survivin-xiap complex promotes increased xiap stability against ubiquitination/proteasomal destruction and synergistic apoptosis | SIGNOR-126367 |
P43657 | P08754 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256868 |
Q9BXM7 | Q7KZI7 | 0 | phosphorylation | up-regulates activity | 0.367 | MARK2 phosphorylated and activated the cleaved form of PINK1 (DeltaN-PINK1 | SIGNOR-278975 |
P15941 | P06239 | 0 | phosphorylation | up-regulates activity | 0.46 | The present results demonstrate that Lck phosphorylation of MUC1 on Y-46 also increases binding of MUC1 and beta-catenin. The results further show that ZAP-70 phosphorylation of MUC1-CD stimulates the interaction of MUC1 and beta-catenin | SIGNOR-249358 |
P06493 | Q99640 | 2 | phosphorylation | down-regulates activity | 0.752 | Active Cdk1 phosphorylates and inhibits Wee1 and Myt1 kinases and phosphorylates and activates the Cdc25 phosphatases. | SIGNOR-279600 |
Q5S007 | Q92997 | 2 | binding | up-regulates | 0.48 | Subsequent assays confirmed a direct interaction between the lrrk2 roccor domain and all three human dvl proteins, these data are consistent with a role for lrrk2 in the activation of canonical wnt signaling bringing dvl proteins to cellular membranes. | SIGNOR-202187 |
P24941 | Q8WZ60 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | We confirmed the formation of ubiquitin and CDK2 by different systems and further identified the E3 ligase KLHL6 as a mediator of the ubiquitination and degradation of CDK2. | SIGNOR-272310 |
O00327 | P51449 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.502 | As RORs function as transcriptional activators and their expression correlates with histone acetylation and chromatin accessibility, RORs are thought to function as positive regulators of Bmal1 expression at its peak levels, whereas REV-ERBs block ROR and negatively regulate Bmal1 at the trough of its expression. | SIGNOR-268004 |
Q8N2W9 | Q12888 | 1 | sumoylation | up-regulates | 0.637 | Pias1 and pias4 are recruited to dna-damage sites and mediate 53bp1 recruitment and sumoylation | SIGNOR-162167 |
Q13285 | Q9HAZ1 | 0 | phosphorylation | up-regulates activity | 0.2 | Immunoblotting analyses showed that the phosphorylation status of NR5A1 at Ser203 was attenuated by the CLK1/4 inhibitor. | SIGNOR-274117 |
P19086 | P50406 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257274 |
O60675 | P54821 | 2 | binding | down-regulates activity | 0.273 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221932 |
P35222 | Q92729 | 0 | dephosphorylation | down-regulates activity | 0.4 | Protein tyrosine phosphatase receptor U (PTPRU) has been shown to be a tumor suppressor in colon cancer by dephosphorylating \u03b2-catenin and reducing the activation of \u03b2-catenin signaling. | SIGNOR-277095 |
P04637 | Q92570 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.264 | We showed that p53 directly bound the promoter of NR4A3 gene and induced its transcription. p53 transactivates the NR4A3 promoter in H1299 cells. | SIGNOR-256200 |
Q8TB45 | P35790 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | These data suggests that CKI overexpression may overcome a requirement for phosphorylation at the major mTOR sites in DEPTOR for formation of the degron and are consistent with our finding that CKI can phosphorylate S286 and S287 in DEPTOR in vitro in the absence of mTOR. | SIGNOR-279605 |
O95379 | P08754 | 2 | binding | up-regulates activity | 0.2 | TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transformation | SIGNOR-256490 |
Q6ZUJ8 | P42336 | 2 | binding | up-regulates | 0.416 | This accumulation of tyrosine-phosphorylated bcap at the membrane with its associated pi3k would then allow for the catalysis of ptd ins p2 to ptd ins p3 and downstream pi3k-dependent signals. Therefore, bcap is an essential activator of the pi3k pathway downstream of tlr signaling, providing a brake to limit potential... | SIGNOR-191664 |
Q02556 | Q06124 | 0 | dephosphorylation | down-regulates activity | 0.353 | We found that Bcr-abl-induced, Shp2 dependent dephosphorylation of Icsbp impaired repression of GAS2 by this transcription factor. | SIGNOR-277173 |
O60664 | P51151 | 0 | null | up-regulates activity | 0.591 | Rab9-dependent transport from late endosomes to the Golgi requires the Rab9 effectors p40 (Diaz et al., 1997) and TIP47 (Diaz and Pfeffer, 1998), a protein that recognizes the cytoplasmic domains of the two types of MPRs and packages them into nascent transport vesicles (Carroll et al., 2001). MPR recycling also utiliz... | SIGNOR-253089 |
P35790 | Q00987 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.274 | The data presented here provides evidence for a molecular mechanism by which CKI-dependent phosphorylation of Mdm2 at multiple sites triggers SCF \u03b2-TRCP -mediated Mdm2 destruction ( xref ). | SIGNOR-279606 |
Q13315 | Q9BUR4 | 1 | phosphorylation | up-regulates activity | 0.337 | Here, we show that in response to various types of DNA damage, including IR and UV, WRAP53β is phosphorylated on serine residue 64 by ATM with a time-course that parallels its accumulation at DNA lesions. Interestingly, recruitment of phosphorylated WRAP53β (pWRAP53βS64) to sites of such DNA damage promotes its interac... | SIGNOR-273511 |
P22888 | P01229 | 2 | binding | up-regulates | 0.684 | Hcg is a heterodimeric glycoprotein hormone, consisting of a common? -subunit and a hormone-specific ?-Subunit (2). It binds to the lh receptor (lhr). | SIGNOR-70028 |
Q01082 | P68400 | 0 | phosphorylation | down-regulates | 0.334 | We show here that the short c-terminal splice variant of betaii-spectrin (betaiisigma2) is a substrate for phosphorylation. In vitro, protein kinase ck2 phosphorylates ser-2110 and thr-2159 / phosphorylation of ?II?2 C-terminal fragment inhibits its interaction with ?II N-terminal fragment. | SIGNOR-150471 |
O96019 | P50750 | 0 | phosphorylation | up-regulates activity | 0.323 | Collectively, these results suggest that the cdk9 and Cyclin T complex more efficiently phosphorylates Baf53 in vitro. | SIGNOR-279689 |
P19784 | Q14005 | 1 | phosphorylation | up-regulates activity | 0.326 | We now show that N-terminal to the NLS domain of pro-IL-16 are protein kinase CK2 substrate and cdc2 kinase substrate sites which, along with the NLS, constitute a dual phosphorylation-regulated CcN motif which regulates nuclear localization of pro-IL-16. In addition, we demonstrate that mutation of either site is asso... | SIGNOR-251009 |
O96017 | P67775 | 0 | dephosphorylation | up-regulates activity | 0.432 | Protein phosphatase 2A interacts with Chk2 and regulates phosphorylation at Thr-68 after cisplatin treatment of human ovarian cancer cells|In response to DNA damage, Chk2 is initially phosphorylated at Thr-68, which leads to its full activation. | SIGNOR-248617 |
P83916 | Q7Z589 | 2 | binding | up-regulates activity | 0.2 | The binding sites for HP1β and BS69 with EMSY abut each other, and are found directly adjacent to the ENT domain of EMSY. This demonstrates that EMSY has the capacity to contact directly at least two proteins which contain a Royal Family domain. Since this domain is found in proteins with a chromatin connection, we ass... | SIGNOR-263917 |
O60858 | P22736 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | These results suggest that Trim13 activity mediates Nur77 ubiquitination, leading to its degradation. | SIGNOR-278564 |
Q99705 | P50148 | 2 | binding | up-regulates activity | 0.529 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257302 |
Q9BX63 | P38398 | 2 | binding | up-regulates activity | 0.796 | BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT repeats of BRCA1. Moreover, BACH1 likely contributes to the DNA repair function of BRCA1 []. | SIGNOR-259185 |
O14795 | Q9UJD0 | 0 | relocalization | up-regulates activity | 0.266 | N-terminal interactions of RIMs with RAB3 and MUNC13 regulate DCV fusion. Through N-terminal interactions, RIMs position MUNC13 and recruit DCVs via RAB3, which is located on the vesicle | SIGNOR-264384 |
Q8N5S9 | P0DP24 | 2 | binding | up-regulates | 0.488 | The binding of Ca2+/CaM to CaM-KK is absolutely required for its activation and efficient phosphorylation of target protein kinases | SIGNOR-266328 |
Q8IWV1 | P43405 | 0 | phosphorylation | up-regulates activity | 0.378 | Upon stimulation via the B or T cell receptors, LAX is rapidly phosphorylated by Src and Syk family tyrosine kinases and interacts with Grb2, Gads, and p85. | SIGNOR-273535 |
P30304 | P14635 | 1 | dephosphorylation | up-regulates activity | 0.855 | Cdc25A dephosphorylates and activates CyclinE\u2013Cdk2, CyclinA\u2013Cdk2 and CyclinB\u2013Cdk1, whereas Cdc25B and Cdc25C primarily target CyclinB\u2013Cdk1 [4,5] . | SIGNOR-277137 |
P35372 | P08754 | 2 | binding | up-regulates activity | 0.513 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256854 |
O00141 | Q92542 | 1 | phosphorylation | down-regulates quantity | 0.337 | Furthermore, SGK1 directly bound to and phosphorylated Nicastrin on Ser437, thereby promoting protein degradation.|We showed that SGK1 downregulates Nicastrin protein levels. | SIGNOR-280122 |
P61812 | P37173 | 2 | binding | up-regulates | 0.754 | We show that tbetarii-b, an alternatively spliced variant of the tgf-beta type ii receptor, is a tgf-beta2 binding receptor, which mediates signalling via the smad pathway in the absence of any tgf-beta type iii receptor | SIGNOR-104795 |
P14618 | P30304 | 0 | dephosphorylation | up-regulates activity | 0.487 | Cdc25A dephosphorylates PKM2 at S37, and promotes PKM2 dependent beta-catenin transactivation and c-Myc-upregulated expression of the glycolytic genes GLUT1, PKM2 and LDHA, and of CDC25A; thus, Cdc25A upregulates itself in a positive feedback loop.|Cdc25A dephosphorylates PKM2 at S37, and promotes PKM2-dependent \u03b2... | SIGNOR-276967 |
Q14164 | Q14653 | 1 | phosphorylation | up-regulates activity | 0.741 | Virus-induced phosphoactivation of irf-3, thought to be mediated directly or indirectly by ikk? And/or tbk1 occurs in the c-terminal region of irf-3 at seven ser/thr residues, 385sslentvdlhisnshplslts405 (fig. 1a).Within This region, irf-3 has two phosphorylation sites: site 1 includes ser385 and ser386, whereas site 2... | SIGNOR-178379 |
Q09472 | Q92585 | 2 | acetylation | up-regulates | 0.651 | The n-terminal domain of maml1 directly interacts with both p300 and histones, and the p300-maml1 complex specifically acetylates histone h3 and h4 tails in chromatin. Furthermore, p300 acetylates maml1 and evolutionarily conserved lysine residues in the maml1 n-terminus are direct substrates for p300-mediated acetylat... | SIGNOR-153035 |
P14136 | P17612 | 0 | phosphorylation | down-regulates activity | 0.283 | GFAP can serve as a substrate for phosphorylation by CAMP-dependent protein kinase. CAMP-dependent protein kinase or protein kinase C phosphorylated Ser-8, Ser-13, and Ser-34.each phosphorylation was shown to induce disassembly of the glial filaments. | SIGNOR-249713 |
P04628 | Q9NPG1 | 2 | binding | up-regulates activity | 0.628 | Wnt proteins bind to the frizzled receptors and lrp5/6 co-receptors, and through stabilizing the critical mediator betBeta-catenin, initiate a complex signaling cascade that plays an important role in regulating cell proliferation and differentiation. | SIGNOR-131571 |
P49841 | Q9BPU6 | 1 | phosphorylation | up-regulates activity | 0.431 | The T516 phosphorylation was achieved by the glycogen synthase kinase-3beta (GSK-3beta), which can phosphorylate the wildtype protein but not the non-phosphorylatable mutant. Furthermore, we have shown that T516 phosphorylation is essential for the tubulin-binding property of CRMP5. Therefore, CRMP5-induced growth inhi... | SIGNOR-264835 |
P62140 | P42575 | 1 | dephosphorylation | up-regulates activity | 0.2 | Nutrient-replete oocytes inhibit C2 via S135 phosphorylation catalyzed by calcium/calmodulin-dependent protein kinase II. We now show that C2 phosphorylated at S135 binds 14-3-3zeta, thus preventing C2 dephosphorylation. Moreover, we determined that S135 dephosphorylation is catalyzed by protein phosphatase-1 (PP1), wh... | SIGNOR-248576 |
P59768 | P62873 | 2 | binding | up-regulates activity | 0.94 | GNG2 dissociates from the activated receptor, bound with GNB1 as stable dimer. | SIGNOR-251106 |
P06400 | Q01094 | 2 | binding | down-regulates activity | 0.921 | E2f binds rb. E2f activation domain is the target for rb-induced repression. Rb can silence the 57 residue e2f activation domain. Rb can mask e2f residues involved in the activation process, possibly by mimicking a component of the transcriptional machinery | SIGNOR-37305 |
P04637 | O43474 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.56 | Previous work has shown that the Kruppel-like factor 4 (KLF4) transcription factor represses p53 transcription by binding to the PE21 element. | SIGNOR-270544 |
Q8WXE1 | P24941 | 0 | phosphorylation | up-regulates | 0.579 | Atrip is a cdk2 substrate, and cdk2-dependent phosphorylation of s224 regulates the ability of atr-atrip to promote cell cycle arrest in response to dna damage./ One possibility is s224 phosphorylation creates a binding site for another protein involved in the g2-m checkpoint response | SIGNOR-156928 |
P05787 | Q16539 | 0 | phosphorylation | up-regulates | 0.592 | Keratin 8 (k8) serine 73 occurs within a relatively conserved type ii keratin motif ((68)nqsllspl) and becomes phosphorylated in cultured cells and organs during mitosis, cell stress, and apoptosis. Here we show that ser-73 is exclusively phosphorylated in vitro by p38 mitogen-activated protein kinase.The ser-73 --> al... | SIGNOR-114079 |
P31749 | Q15672 | 1 | phosphorylation | up-regulates | 0.438 | Moreover, phosphorylation of twist-1 at ser42 was shown in vivo in various human cancer tissues, suggesting that this post-translational modification ensures functional activation of twist-1 after promotion of survival during carcinogenesis. | SIGNOR-164884 |
O14641 | P48730 | 0 | phosphorylation | up-regulates | 0.534 | Ck1_/__dependent phosphorylation of dvl2 at s143 and t224and that this event is critical to interact with plk1 in early stages of the cell cycle | SIGNOR-197547 |
O43791 | O75496 | 1 | ubiquitination | down-regulates activity | 0.2 | SPOP promotes K27-linked non-degradative poly-ubiquitination of Geminin at lysine residues 100 and 127. This poly-ubiquitination of Geminin prevents DNA replication over-firing by indirectly blocking the association of Cdt1 with the MCM protein complex, an interaction required for DNA unwinding and replication. | SIGNOR-268926 |
Q16816 | P06737 | 1 | phosphorylation | up-regulates activity | 0.54 | It is well-characterized that GP is activated by PhK-mediated serine phosphorylation at Ser-15 | SIGNOR-267399 |
P04626 | P03372 | 1 | phosphorylation | up-regulates | 0.572 | The results presented here show for the first time that er redistribution to the cytoplasm and its interaction with her2 are important downstream effects of her2 overexpression, that erk1/2 is important for er cytoplasmic localization, and that subcellular localization of er may play a mechanistic role in determining t... | SIGNOR-124962 |
P51812 | Q9Y4K3 | 1 | phosphorylation | up-regulates activity | 0.272 | These results demonstrate that TRAF6 K63 ubiquitination might be regulated by an RSK2 mediated phosphorylation dependent mechanism and phosphorylation of TRAF6 at Ser46, 47 and 48 enhances its ubiquitin mediated inflammation signaling. | SIGNOR-278302 |
P31749 | P12268 | 1 | phosphorylation | up-regulates activity | 0.386 | Further, we have demonstrated an in vivo association of IMPDH and PKB/Akt by co‐immunoprecipitation from COS cells expressing a constitutively active form of PKB/Akt. Finally, we were able to show that this constitutively active PKB/Akt could phosphorylate IMPDH in vitro. Thus, the interplay between PKB/Akt and IMPDH r... | SIGNOR-261262 |
P49336 | P46531 | 1 | phosphorylation | down-regulates | 0.552 | Purified recombinant cycc:cdk8 phosphorylates the notch icd within the tad and pest domains, and expression of cycc:cdk8 strongly enhances notch icd hyperphosphorylation and pest-dependent degradation by the fbw7/sel10 ubiquitin ligase in vivo. | SIGNOR-130640 |
P05107 | Q05655 | 0 | phosphorylation | up-regulates | 0.329 | In this study, we present evidence that pkc isoforms are the major protein kinases that phosphorylate the c terminus of the integrin cd18 chain in leukocytes. Ser-745 is identified as a novel phosphorylation site in the integrin cytoplasmic domain. Additionally, we show that a thr-758-phosphorylated integrin peptide ca... | SIGNOR-178897 |
Q92673 | P02649 | 2 | binding | up-regulates | 0.62 | Lr11 binds the apolipoprotein e (apoe)-rich lipoproteins, beta-very low density lipoproteins (vldls), with a high affinity similar to that of other members, such as the ldlr and vldl receptor.Incubation For 48 hours with beta-vldl of lr11-overexpressing cells, but not of control cells, promotes the appearance of numero... | SIGNOR-110555 |
P63096 | P30556 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256738 |
P29350 | P12931 | 2 | dephosphorylation | up-regulates activity | 0.527 | Several protein tyrosine phosphatases are capable of activating Src by dephosphorylating Y530 (reviewed in ref. 9). These include PTP-α, PTP-λ, SHP-1, SHP-2, and PTP1B | SIGNOR-248472 |
P05771 | P04049 | 1 | phosphorylation | up-regulates | 0.445 | Pkc can effectively phosphorylate raf-1, this is a direct effect of activated pkc and not the result of raf-1 autophosphorylation. the sites of pkc-mediated raf-1 phosphorylation are deduced to be ser497 and ser619. | SIGNOR-37474 |
P56211 | Q96GX5 | 0 | phosphorylation | up-regulates activity | 0.73 | We identified cyclic adenosine monophosphateregulated phosphoprotein 19 (Arpp19) and -Endosulfine as two substrates of Gwl that, when phosphorylated by this kinase, associate with and inhibit PP2A, thus promoting mitotic entry. | SIGNOR-243611 |
Q8TDC3 | P23258 | 1 | phosphorylation | up-regulates | 0.248 | Sadb kinases associate and phosphorylate gamma-tubulin on ser 131 s131d gamma-tubulin expression amplifies centrosome duplication | SIGNOR-187405 |
P30405 | P49841 | 0 | phosphorylation | up-regulates activity | 0.378 | Phosphorylation of cyclophilin D at serine 191 regulates mitochondrial permeability transition pore opening and cell death after ischemia-reperfusion|We conclude that CypD phosphorylation at S191 residue leads to its binding to OSCP and thus sensitizes mPTP opening for the subsequent cell death.|Under baseline conditio... | SIGNOR-264880 |
P01106 | Q8N699 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.298 | MT-MC1 is a widely expressed nuclear protein whose overexpression, unlike that of c-Myc targets reported previously, recapitulates multiple c-Myc phenotypes. These include promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instabil... | SIGNOR-261736 |
Q06945 | O00560 | 2 | binding | up-regulates activity | 0.538 | Sox4 activation by IL-5R_ appears to be direct, with syntenin functioning as an adaptor molecule. Syntenin mediates IL-5induced Sox4 activation. | SIGNOR-223089 |
P63000 | P15498 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.765 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260581 |
Q16539 | P03372 | 1 | phosphorylation | up-regulates | 0.625 | Conversely, constitutively active mkk6 induced p38 mapk activation that recapitulated the effects of polyphenols by inducing eralpha phosphorylation and downstream activation of akt, and enos. The key role of eralpha ser-118 phosphorylation was confirmed in enos-transfected cos-7 cells | SIGNOR-136950 |
P35222 | P55285 | 2 | binding | up-regulates activity | 0.578 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265868 |
P50148 | Q99677 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257383 |
P08238 | Q8TF40 | 2 | binding | down-regulates activity | 0.2 | FNIP1 and FNIP2 facilitate FLCN binding to Hsp90 chaperone. Our results suggest that FNIP1 is a potent inhibitor of Hsp90 ATPase activity, as 200 nM of FNIP1 inhibits Hsp90 ATPase activity by 50-fold. FNIP2 also has shown inhibitory activity towards Hsp90; however, it required 1.6 μM of FNIP2 to inhibit the ATPase act... | SIGNOR-261415 |
P38405 | P32239 | 2 | binding | up-regulates activity | 0.265 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256908 |
Q13131 | Q6N021 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | We identify the tumour suppressor TET2 as a substrate of the AMP-activated kinase (AMPK), which phosphorylates TET2 at serine 99, thereby stabilizing the tumour suppressor. Increased glucose levels impede AMPK-mediated phosphorylation at serine 99, which results in the destabilization of TET2 followed by dysregulation ... | SIGNOR-256134 |
A6ND36 | P48729 | 2 | binding | up-regulates quantity | 0.373 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273745 |
P00738 | Q9NZP8 | 0 | cleavage | up-regulates activity | 0.375 | We demonstrate that coexpression of the proform of Hp (proHp) and C1r-LP in COS-1 cells effected cleavage of proHp in the endoplasmic reticulum. This cleavage depended on proteolytic activity of C1r-LP because mutation of the putative active-site Ser residue abolished the reaction. Furthermore, incubation of affinity-p... | SIGNOR-256358 |
Q96LB2 | P50148 | 2 | binding | up-regulates activity | 0.342 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257384 |
P07195 | O14965 | 0 | phosphorylation | up-regulates activity | 0.2 | Aurora-A-mediated phosphorylation of LDHB serine 162 significantly increases its activity in reducing pyruvate to lactate, which efficiently promotes NAD+ regeneration, glycolytic flux, lactate production and bio-synthesis with glycolytic intermediates. | SIGNOR-277493 |
P24723 | Q15139 | 1 | phosphorylation | up-regulates | 0.355 | These results provide direct evidence that pkd becomes activated in vivo as a consequence of pkc-mediated phosphorylation of serines 744 and 748. | SIGNOR-66734 |
P08754 | P48039 | 2 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256849 |
P12931 | Q9Y2X7 | 1 | phosphorylation | up-regulates activity | 0.542 | Tyrosines 246 and 293 are required to hold GIT1 in a closed conformation.Hyperphosphorylation of GIT1-N by Src and pervanadate does not affect its binding in vitro to full length GIT1 proteins. Mutations Y246E and Y293E of GIT1 enhance binding to paxillin. | SIGNOR-276627 |
P35568 | Q15418 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.358 | Negative feedback involves s6k, which inactivates irs by phosphorylation at multiple sites, thus inducing its degradation and altered cell localization. | SIGNOR-175687 |
P12931 | P52789 | 1 | phosphorylation | up-regulates activity | 0.362 | Here we find that c-Src can interact with and phosphorylate hexokinases HK1 and HK2, the rate limiting enzymes in glycolysis.|Moreover, c-Src could efficiently stimulate the catalytic activities of HK1 and HK2, but failed to stimulate their corresponding mutants (XREF_FIG and XREF_SUPPLEMENTARY). | SIGNOR-278499 |
P23458 | Q8NI17 | 2 | binding | up-regulates | 0.497 | Il-31 can activate janus kinase (jak) 1 and jak2 signaling molecules after binding to its receptor complex. | SIGNOR-161342 |
Q2M2I8 | Q96CW1 | 1 | phosphorylation | up-regulates | 0.79 | Aak1 is enriched at presynaptic terminals, whereas in nonneuronal cells it colocalizes with clathrin and ap2 in clathrin-coated pits and at the leading edge of migrating cells. Aak1 specifically phosphorylates the mu subunit in vitro, and stage-specific assays for endocytosis show that mu phosphorylation by aak1 result... | SIGNOR-115657 |
Q9UNW8 | P19086 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257275 |
P10451 | P15036 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.251 | We demonstrated that Ets2 is capable of binding to and transactivating the OPN promoter using gel shift and transient transfection assays | SIGNOR-259872 |
P08754 | P28223 | 2 | binding | up-regulates activity | 0.268 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256885 |
O96013 | Q16236 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | PAK4 directly phosphorylated Nrf2 at T369, and it led to its nuclear export and proteasomal degradation, all of which impaired antioxidant responses in hepatocytes. | SIGNOR-277583 |
P05412 | P17947 | 2 | binding | up-regulates activity | 0.555 | These results indicate that AML1-ETO competes c-Jun away from binding to the β3β4 domain of PU.1. Thus, the c-Jun coactivation function of PU.1 is down-regulated and this in turn down-regulates transcriptional activity of PU.1. | SIGNOR-255660 |
P01042 | P03952 | 0 | cleavage | up-regulates activity | 0.779 | Bradykinin is a nonapeptide composed of the sequence Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg and functions as an inflammatory mediator. BK is the product of the kallikrein–kinin system following activation of FXII. FXIIa leads to proteolysis of PK, and the resulting PKa cleaves HK to generate BK (Figure 1). | SIGNOR-263548 |
P07101 | P51812 | 0 | phosphorylation | up-regulates | 0.267 | Mitogen-activated protein-kinase (map) kinase-activated protein kinases 1 and 2 (mapkap kinase-1, mapkap kinase-2), were found to phosphorylate bacterially expressed human tyrosine hydroxylaserecombinant human tyrosine hydroxylase (hth1) was found to be phosphorylated by mitogen and stress-activated protein kinase 1 (m... | SIGNOR-34682 |
P43034 | Q8WVJ2 | 2 | binding | up-regulates quantity by stabilization | 0.44 | The type I lissencephaly gene product LIS1, a key regulator of cytoplasmic dynein, is critical for cell proliferation, survival, and neuronal migration. However, little is known about the regulation of LIS1. Here, we identify a previously uncharacterized mammalian homolog of Aspergillus NudC, NudCL2 (NudC-like protein ... | SIGNOR-252167 |
P10721 | Q06124 | 1 | phosphorylation | up-regulates activity | 0.684 | SHP2 can be phosphorylated at 2 C-terminal tyrosyl residues by receptor tyrosine kinases, including KIT as well as cytosolic tyrosine kinases, including Src and Abl. The level of tyrosyl phosphorylation of SHP2 has been associated with its recruitment to the receptor.Thus, pharmacologic inhibition of SHP2 phosphatase f... | SIGNOR-256140 |
Q969H4 | P54762 | 2 | binding | up-regulates activity | 0.293 | The phosphorylated CNK1 interacts with ephrinB1. The binding of ephrinB1 to CNK1 connects RhoA and p115RhoGEF with ephrinB1-associated MKK4, promoting JNK activation and cell migration. | SIGNOR-275921 |
P05412 | P01100 | 2 | binding | up-regulates activity | 0.953 | The cFos proto-oncoprotein associates with cJun to form a heterodimer with increased DNA binding and transcriptional activities. | SIGNOR-252087 |
P08651 | Q9HCE7 | 0 | ubiquitination | down-regulates quantity | 0.329 | In addition, Smurf1 knockdown also blocked the degradation of endogenous NFI-C in response to TGF-beta1 (XREF_FIG).|In particular, Smurf1 and Smurf2 markedly increased the polyubiquitination of NFI-C in the presence of TGF-beta1 (XREF_FIG and XREF_SUPPLEMENTARY). | SIGNOR-278753 |
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