IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P20248 | P30304 | 0 | dephosphorylation | up-regulates activity | 0.692 | Cdc25A dephosphorylates and activates CyclinE\u2013Cdk2, CyclinA\u2013Cdk2 and CyclinB\u2013Cdk1, whereas Cdc25B and Cdc25C primarily target CyclinB\u2013Cdk1 [4,5] . | SIGNOR-277136 |
O75030 | Q15661 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | The transcription of tryptase gene in human mast cells is regulated by mi transcription factor |Using mutant constructs of tryptase promoter, we observed that two E-box (CANNTG) motifs including between -817 to -715 and -421 to -202 are able to involve in the transactivation of tryptase gene by MITF-A. | SIGNOR-251725 |
Q96K19 | Q14643 | 1 | polyubiquitination | down-regulates activity | 0.431 | In summary, here we present evidence that RNF170 is an E3 ligase that mediates IP3 receptor ubiquitination and processing by the UPP and that it is recruited to activated IP3 receptors by the erlin1/2 complex to which it is constitutively bound. | SIGNOR-271913 |
P40763 | Q9HC98 | 0 | phosphorylation | up-regulates activity | 0.332 | Our data also show that NEK6 interacts with STAT3, an oncogenic transcription factor, and phosphorylates STAT3 on Ser(727), which is important for transcriptional activation. These results demonstrate that NEK6 interacts with and phosphorylates STAT3, an event that could play an important role in oncogenesis. For the m... | SIGNOR-273902 |
P35222 | O14965 | 0 | phosphorylation | up-regulates quantity | 0.346 | In addition, Aurora-A overexpression is significantly correlated with increased cytoplasmic \u03b2-catenin expression in esophageal squamous cell carcinoma tissues.|We also demonstrate for the first time that Aurora-A directly interacts with \u03b2-catenin and phosphorylates \u03b2-catenin at Ser552 and Ser675. | SIGNOR-278468 |
Q96NI6 | P10586 | 2 | binding | up-regulates activity | 0.351 | SALM5 trans-synaptically interacts with LAR-RPTPs in a splicing-dependent manner to regulate synapse development. we identified LAR-RPTPs as novel ligands of SALM5 that mediates SALM5-dependent presynaptic differentiation in a splicing-dependent manner. Our data indicate that SALM5 interacts with all three known LAR-RP... | SIGNOR-264087 |
Q93077 | Q86Y13 | 0 | monoubiquitination | up-regulates activity | 0.2 | 2A-HUB catalyzes monoubiquitination of H2A at lysine 119, functioning as a combinatoric component of the repression machinery required for specific gene regulation programs. Thus, 2A-HUB mediates a selective repression of a specific set of chemokine genes in macrophages, critically modulating migratory responses to TL... | SIGNOR-271759 |
P60321 | Q99619 | 2 | binding | down-regulates quantity by destabilization | 0.2 | We have identified SPRY domain-containing SOCS (suppressor of cytokine signaling) box protein 2 (SPSB2) as a novel negative regulator that recruits an E3 ubiquitin ligase complex to polyubiquitinate iNOS, resulting in its proteasomal degradation. A cell-free ubiquitination assay was established to demonstrate SPSB2-dep... | SIGNOR-271901 |
P54253 | P12830 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.343 | Overexpression of the CtBP2 protein enhanced the repression activity of the E-cadherin promoter in a dose-dependent manner, whereas overexpression of ataxin-1 increased the activity of the E-cadherin promoter in a dose-dependent manner | SIGNOR-261577 |
Q14344 | P41231 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257233 |
O60271 | Q15759 | 2 | binding | up-regulates | 0.446 | Cdo, jlp, and p38alpha/beta form complexes in differentiating myoblasts, and cdo and jlp cooperate to enhance levels of active p38alpha/beta in transfectants. | SIGNOR-150147 |
Q05397 | P51813 | 0 | phosphorylation | up-regulates | 0.551 | Bmx phosphorylated focal adhesion kinase (fak) at tyr577 subsequent to its src-mediated phosphorylation at tyr576. Loss of bmx by rna interference or by genetic deletion in mouse embryonic fibroblasts (mefs) markedly impaired fak activity. | SIGNOR-202139 |
O15530 | Q13153 | 1 | phosphorylation | up-regulates activity | 0.357 | P21-activated kinase (PAK1) is phosphorylated and activated by 3-phosphoinositide-dependent kinase-1 (PDK1). We identify threonine 423, a conserved threonine in the activation loop of kinase subdomain VIII, as the PDK1 phosphorylation site on PAK1. | SIGNOR-250267 |
P50406 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257274 |
P17252 | Q38SD2 | 1 | phosphorylation | up-regulates activity | 0.2 | PKCα unexpectedly does not activate LRRK1 by phosphorylating the kinase domain, but instead phosphorylates a cluster of conserved residues (Ser1064, Ser1074 and Thr1075) located within a region of the CORB domain of the GTPase domain. we postulate that phosphorylation of Ser1064, Ser1074 and Thr1075 activates LRRK1 by ... | SIGNOR-276865 |
Q96GD4 | P01106 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.373 | AURKB directly phosphorylates MYC at serine 67, counteracting GSK3\u03b2-directed threonine 58 phosphorylation and subsequent FBXW7- mediated proteasomal degradation. | SIGNOR-279439 |
Q15858 | Q92914 | 2 | binding | down-regulates activity | 0.2 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253426 |
Q03393 | Q13237 | 0 | phosphorylation | up-regulates | 0.53 | Upon expression in cos-1 cells, ptps-s19a was stable but not phosphorylated and had a reduced activity of approximately 33% in comparison to wild-type ptps. Addition of cgmp stimulated phosphotransferase activity 2-fold. Extracts from transfected cos-1 cells overexpressing cgkii stimulated ser(19) phosphorylation more ... | SIGNOR-71751 |
O00548 | Q86YT6 | 0 | ubiquitination | up-regulates activity | 0.743 | Mib physically interacts with Delta and promotes its ubiquitination and internalization [66], which have been shown to up-regulate Notch activity. | SIGNOR-209750 |
Q9NRM7 | O95863 | 1 | phosphorylation | up-regulates | 0.528 | Lats2 kinase potentiates snail1 activity by promoting nuclear retention upon phosphorylation. during tgf_-induced emt lats2 is activated and snail1 phosphorylated at t203. | SIGNOR-176647 |
P30550 | O95837 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257421 |
P55273 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | Cdk2 and pka were found to participate in p19ink4d phosphorylation process and that they would mediate serine 76 and threonine 141 modifications respectively. Nuclear translocation of p19ink4d induced by dna damage was shown to be dependent on serine 76 phosphorylation. | SIGNOR-197285 |
P22681 | P15498 | 2 | binding | up-regulates | 0.692 | Hese data imply that c-cbl is a molecular adapter that regulates the function of vav | SIGNOR-49188 |
Q96S52 | Q92643 | 2 | binding | up-regulates activity | 0.943 | To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1... | SIGNOR-261362 |
Q02156 | Q9BPZ7 | 2 | binding | up-regulates activity | 0.263 | In the present study, we have identified the mTORC2 subunit Sin1 as a direct binding partner of the PKC (protein kinase C) ε kinase domain and map the interaction to the central highly conserved region of Sin1. Exploiting the conformational dependence for PKC phosphorylation, we demonstrate that mTORC2 is essential for... | SIGNOR-276348 |
Q9NZ42 | Q8WW43 | 2 | binding | up-regulates | 0.942 | Furthermore, overexpression of aph-1 facilitates pen-2-mediated ps1 proteolysis, resulting in a significant increase in ps1 fragments. Our data reveal a direct role of pen-2 in proteolytic cleavage of ps1 and a regulatory function of aph-1, in coordination with pen-2, in the biogenesis of the ps1 complex. | SIGNOR-97110 |
P49840 | Q96BR1 | 0 | phosphorylation | down-regulates activity | 0.354 | Phosphorylation of GSK3 by PKB or SGK1 inhibits GSK3 activity|estern blotting using an antibody specific for the PKB/SGK1 consensus phosphorylation site in GSK3a/beta (serine 21 and 9 respectively) revealed an increase in GSK3a/beta phosphorylation in human embryonic kidney 293 (HEK293) cells overexpressing wild type S... | SIGNOR-249165 |
Q9H4B4 | P37840 | 1 | phosphorylation | down-regulates activity | 0.319 | Polo-like kinase (plk) family (plk1, plk2, and plk3) phosphorylate alpha-syn and beta-syn specifically at ser-129 and ser-118, respectively. Polo-like kinase 2 (plk2) phosphorylates alpha-synuclein at serine 129 in central nervous system. The membrane association of pd-linked mutant alpha -synuclein, but not wild-type ... | SIGNOR-189053 |
Q5H9F3 | Q8WUI4 | 2 | binding | up-regulates activity | 0.48 | BCoR-L1 interacts with Class II HDACs, HDAC4, HDAC5, and HDAC7, suggesting that they are involved in its function as transcriptional corepressor. | SIGNOR-259114 |
Q99836 | Q01638 | 2 | binding | up-regulates activity | 0.655 | As shown in Figure 3D, MyD88, IRAK, IRAK4, and TRAF6 are all recruited to ST2 upon IL-33 stimulation. | SIGNOR-277704 |
Q86VS8 | Q9UEW3 | 2 | binding | down-regulates | 0.2 | We have identified a microtubule-binding protein, hook3, as a novel interacting partner of sr-a. / by transfecting small interfering rna targeting hook3, total and surface expression, receptor-mediated ligand uptake and protein stability of sr-a were significantly promoted, whereas the protein synthesis and maturation ... | SIGNOR-152268 |
P05771 | P04083 | 1 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202784 |
P06493 | Q14493 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.419 | Phosphorylation of threonine 61 by cyclin a/Cdk1 triggers degradation of stem-loop binding protein at the end of S phase | SIGNOR-265258 |
P30679 | Q9BPV8 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257143 |
Q9UQ13 | P27361 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.335 | Here, we showed that SHOC2, a RAS activator, is a FBXW7 substrate. Growth stimuli trigger SHOC2 phosphorylation on Thr507 by the mitogen-activated protein kinase (MAPK) signal, which facilitates FBXW7 binding for ubiquitylation and degradation. | SIGNOR-277443 |
P05067 | P24941 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.267 | These include a significant increase in APP phosphorylation at Thr 668 by cdk2, cdk4, and cdk5, which increases its beta-amyloid production and APP proteolysis by the activated caspases during cell cycle ( xref ; xref ; xref ; xref ). | SIGNOR-280210 |
Q8NEG4 | Q8N752 | 2 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273759 |
Q04206 | P49840 | 0 | phosphorylation | up-regulates activity | 0.2 | Redundant functions of GSK-3_ and GSK-3_ through phosphorylation of RelA at Thr-254 play a crucial role in early stages of chondrocyte differentiation | SIGNOR-255827 |
Q9BRS2 | P68400 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.332 | Casein kinase 2 (CK2) phosphorylates RIOK1 at T410, which stabilizes RIOK1 by antagonizing K411 methylation and impeding the recruitment of FBXO6 to RIOK1. | SIGNOR-273630 |
P06239 | P40763 | 1 | phosphorylation | up-regulates activity | 0.699 | Lck was able to induce tyrosine phosphorylation of STAT3 to a level equal to or greater than that induced by Jak2.|This finding, along with the previous data, gives strong evidence that Lck can directly and positively affect STAT3 activity.Our data provide strong evidence that Lck can activate STAT3 via phosphorylation... | SIGNOR-279201 |
Q01196 | Q86X55 | 0 | methylation | down-regulates activity | 0.282 | We have found that PRMT4 is highly expressed in HSPCs, where it functions as an inhibitor of myeloid differentiation (Figure 7G). In these cells, PRMT4 methylates RUNX1 at R223, promoting the assembly of a DPF2-containing transcriptional co-repressive complex, and repressing transcription at the miR-223 locus. | SIGNOR-261967 |
Q96P68 | P08754 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257155 |
P61956 | Q6ZNA4 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.626 | Arkadia ubiquitinates poly-SUMO2 chains in a SIM- and RING-dependent manner. | SIGNOR-272882 |
O75444 | P54821 | 2 | binding | down-regulates activity | 0.353 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221893 |
Q92831 | Q6NXT2 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269617 |
P35579 | P26447 | 2 | binding | down-regulates activity | 0.418 | Our results show that S100A4 regulates cell polarization during directed motility by affecting the localization of protrusions through interactions with myosin-IIA, with S100A4 expressing cells displaying few side protrusions and extensive forward protrusions during chemotaxis compared with control cells. The mechanism... | SIGNOR-269282 |
P35555 | Q9UBX5 | 2 | binding | down-regulates activity | 0.39 | Fibulin-4 and -5 are extracellular glycoproteins with essential non-compensatory roles in elastic fiber assembly. We have determined how they interact with tropoelastin, lysyl oxidase, and fibrillin-1, thereby revealing how they differentially regulate assembly. Both fibulins differentially bound N-terminal fibrillin-1... | SIGNOR-252138 |
P0DP24 | O43303 | 2 | binding | up-regulates activity | 0.2 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-266332 |
P18848 | Q6PI48 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | QRICH1 promotes the expression of translation-related genes. our combined ChIP-seq and RNA-seq analyses identified that QRICH1 and ATF4 were enriched at the promoters of these specific tRNA synthetases, and that ER stress positively regulated their transcription (Fig. 4I). Together, these findings suggest that QRICH1 a... | SIGNOR-269418 |
P58401 | Q8N0W4 | 2 | binding | up-regulates activity | 0.768 | Pre- and postsynaptic plasma membranes are always precisely aligned, and are separated by a synaptic cleft of ~20 nm. The cleft contains an undefined proteinaceous material in the middle, and is presumably bridged by synaptic cell-adhesion molecules such as Nrxns and Nlgns that align the pre- and postsynaptic elements ... | SIGNOR-264160 |
O14944 | P78536 | 0 | cleavage | up-regulates activity | 0.565 | ADAM17 is involved in the release and activation of several growth factors and cytokine receptor ligands. Among the growth factors activated by ADAM17 are TGF-alpha, amphiregulin, epiregulin and HB-EGF | SIGNOR-259843 |
P35813 | Q15797 | 1 | dephosphorylation | down-regulates | 0.538 | In this study, we have found that ppm1a, a metal ion-dependent protein serine/threonine phosphatase, physically interacts with and dephosphorylates smad1 both in vitro and in vivo. considering the highly conserved nature of the sxs motif in all r-smads, we reasoned that ppm1a might also recognize the sxs motif in the ... | SIGNOR-149077 |
P61586 | O15013 | 0 | guanine nucleotide exchange factor | up-regulates activity | 0.525 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260535 |
O76093 | P21802 | 2 | binding | up-regulates | 0.73 | Fgfs bind and activate high-affinity receptor tyrosine kinases. The cloning of fgf receptors (fgfrs) has identified four distinct genes | SIGNOR-42368 |
P63096 | P32239 | 2 | binding | up-regulates activity | 0.274 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257037 |
Q8N884 | P51451 | 0 | phosphorylation | down-regulates activity | 0.2 | DNA damage induces nuclear translocation of cGAS in a manner that is dependent on importin-α, and the phosphorylation of cGAS at tyrosine 215-mediated by B-lymphoid tyrosine kinase-facilitates the cytosolic retention of cGAS. | SIGNOR-275844 |
O15126 | P00533 | 0 | phosphorylation | up-regulates activity | 0.335 | In our efforts to identify cellular tyrosine kinases that phosphorylate SCAMPs, we are quite intrigued by the observation that among a number of kinases, only the EGFR exhibits activity toward SCAMPs. EGF catalyzes the progressive phosphorylation of the SCAMPs up to 1 h poststimulation and may enhance colocalization of... | SIGNOR-262857 |
Q07352 | P49137 | 0 | phosphorylation | down-regulates | 0.62 | Mk2-mediated inhibition of brf1 requires phosphorylation at s54, s92, and s203. Phosphorylation of brf1 by mk2 does not appear to alter its ability to interact with ares or to associate with mrna decay enzymes. Thus, mk2 inhibits brf1-dependent amd through direct phosphorylation. | SIGNOR-161274 |
P05107 | Q9Y490 | 2 | binding | up-regulates activity | 0.719 | Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y mo... | SIGNOR-257618 |
P08238 | P68400 | 0 | phosphorylation | down-regulates | 0.333 | Although the kinase responsible for hsp90? Phosphorylation in vivo is not known, it has been reported that ck2 can phosphorylate these sites in vitro (24). Thus, we prephosphorylated recombinant hsp90? With ck2 before addition to the reaction. Remarkably, hsp90? Phosphorylation greatly reduced its ability to inhibit ap... | SIGNOR-179264 |
Q969H0 | P05412 | 2 | binding | down-regulates quantity by destabilization | 0.495 | We report that in neurons the stability of c-Jun is regulated by the E3 ligase SCF(Fbw7), which ubiquitinates phosphorylated c-Jun and facilitates c-Jun degradation. | SIGNOR-272950 |
P04637 | P24941 | 0 | phosphorylation | up-regulates activity | 0.871 | The N-terminus of E2F1 can interact directly with a region towards the C-terminus of p53, resulting in increased nuclear retention of p53 and p53-mediated transcription and apoptosis. This is inhibited by competition between p53 and cyclin A at the binding site within E2F19,10. The interaction between p53 and E2F1 is e... | SIGNOR-119379 |
Q14653 | P52292 | 0 | relocalization | up-regulates activity | 0.2 | The results from Figure 1C suggest that ORF6 inhibits IFN-β production through IRF3 or a component downstream of IRF3. Thus, we examined the effect of ORF6 on IRF3 nuclear translocation. Upon poly(I:C) treatment, IRF3 translocated to the cell nucleus in the absence of ORF6, whereas the expression of ORF6 blocked its nu... | SIGNOR-262514 |
Q9Y6N7 | Q14938 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268907 |
P61586 | A1A4S6 | 0 | gtpase-activating protein | down-regulates activity | 0.668 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260465 |
Q8IYW5 | P54132 | 1 | ubiquitination | up-regulates activity | 0.262 | Here, we demonstrate that the ubiquitin/SUMO-dependent DNA damage response (UbS-DDR), controlled by the E3 ligases RNF8/RNF168, triggers BLM recruitment to sites of replication fork stalling via ubiquitylation in the N-terminal region of BLM and subsequent BLM binding to the ubiquitin-interacting motifs of RAP80. | SIGNOR-272114 |
P07196 | Q9C040 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.43 | Here, we show that TRIM RING finger protein TRIM2, highly expressed in the nervous system, is an UbcH5a-dependent ubiquitin ligase. We further demonstrate that TRIM2 binds to neurofilament light subunit (NF-L) and regulates NF-L ubiquitination. | SIGNOR-271776 |
P50148 | P41968 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257230 |
P45983 | P16949 | 1 | phosphorylation | down-regulates | 0.316 | Involved in the regulation of the microtubule (mt) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Here we show that in response to hyperosmotic stress, jnk phosphorylates a key cytoplasmic microtubule regulatory protein, stathmin (stmn), on conserved ser-25 an... | SIGNOR-166694 |
O95837 | P29371 | 2 | binding | up-regulates activity | 0.435 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257333 |
Q04206 | P19838 | 2 | binding | up-regulates activity | 0.713 | Here we report the crystal structure at 2.9 a resolution of the p50/p65 heterodimer bound to the kappab dna | SIGNOR-55378 |
O00459 | P37173 | 2 | binding | up-regulates | 0.433 | These studies revealed that PI 3-kinase is associated in vivo with both TGF-_ receptor subtypes and that TGF-_1 stimulation enhances PI 3-kinase activity associated with type I TGF-_ receptor in hASM cells. | SIGNOR-227528 |
P20340 | O43896 | 0 | relocalization | up-regulates quantity | 0.409 | Here, we identify Bicaudal-D-related protein 1 (BICDR-1) as an effector of the small GTPase Rab6 and key component of the molecular machinery that controls secretory vesicle transport in developing neurons. BICDR-1 interacts with kinesin motor Kif1C, the dynein/dynactin retrograde motor complex, regulates the pericentr... | SIGNOR-266877 |
Q13950 | P27361 | 0 | phosphorylation | up-regulates | 0.565 | In this study, we identified two phosphorylation sites in runx2 at ser301 and ser319 that are required for mapk-dependent activation of runx2 transcriptional activity and osteoblast differentiation. | SIGNOR-188347 |
P21802 | Q04760 | 1 | phosphorylation | up-regulates activity | 0.2 | We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of t... | SIGNOR-276184 |
Q96A54 | Q15848 | 2 | binding | up-regulates | 0.677 | Two adiponectin receptors, adipor1 and adipor2, have recently been identified. | SIGNOR-146170 |
Q9Y3I1 | Q96SW2 | 2 | binding | down-regulates quantity by destabilization | 0.257 | We have shown that CRBN is also targeted for degradation by SCFFbxo7 ubiquitin ligase. | SIGNOR-272311 |
P35869 | P49841 | 0 | phosphorylation | up-regulates activity | 0.25 | A proposed model of GSK3β role on AHR function and degradation. AHR is phosphorylated by GSK3β in a p23-dependent manner in HeLa cells. This phosphorylation is required for optimal activation of the ligand-dependent AHR target gene transcription. After phosphorylation, AHR is K63-ubiquitinated and is targeted for the L... | SIGNOR-276664 |
Q8IXJ9 | P42771 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.3 | Modeling ASXL1 mutation revealed impaired hematopoiesis caused by derepression of p16Ink4a through aberrant PRC1-mediated histone modification. These results indicated that loss of protein interaction between Asxl1 mutant and Bmi1 affected the activity of PRC1, and subsequent derepression of p16Ink4a by aberrant histon... | SIGNOR-260119 |
P06493 | O14745 | 1 | phosphorylation | down-regulates activity | 0.276 | During the early stages of mitosis in HeLa cells, Cdc2 phosphorylates EBP50 on serine residues 280 and 302.|Phosphorylation by Cdc2 inhibits EBP50's role in forming microvilli in interphase but not mitotic cells. (A) Results from scoring JEG-3 cells for the presence of microvilli; error bars indicate mean \u00b1 SD. (B... | SIGNOR-278305 |
P12882 | P14859 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238760 |
O15151 | O15297 | 0 | dephosphorylation | up-regulates quantity by stabilization | 0.431 | PPM1D also inhibits p53 activity by dephosphorylating Ser395 and stabilizing MDM2 and by dephosphorylating Ser403 on MDMX | SIGNOR-275491 |
P08236 | P19484 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.249 | Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy|A chromatin immunoprecipitation (ChIP) assay with antibodies against TFEB or ACSS2 demonstrated that glucose deprivation results in the binding of TFEB (Figure 3D) and ACSS2 (Figure 3E) to the promoter regions of CTSA, GBA, GU... | SIGNOR-276553 |
P45985 | Q9NYL2 | 0 | phosphorylation | up-regulates activity | 0.2 | We show here that members of the mixed-lineage kinase (MLK) family (including MLK1, MLK2, MLK3, and dual leucine zipper kinase [DLK]) are expressed in neuronal cells and are likely to act between Rac1/Cdc42 and MKK4 and -7 in death signaling. | SIGNOR-243348 |
O14641 | P53350 | 0 | phosphorylation | up-regulates | 0.465 | Dvl2 bound to and was phosphorylated at thr206 by a mitotic kinase, polo-like kinase 1 (plk1), and this phosphorylation was required for spindle orientation and stable microtubule (mt)-kt attachment | SIGNOR-167858 |
Q00534 | Q01196 | 1 | phosphorylation | up-regulates | 0.615 | We have identified four phosphorylation sites on aml1c that are necessary for transcriptional activity of aml1c in k562 and 293t cells (27).4 mutation of these four sites (serine 276, serine 293, serine 303, and threonine 300) to alanine abolishes transcriptional activation, whereas mutation of these sites to aspartic ... | SIGNOR-138953 |
Q9Y618 | P41182 | 2 | binding | up-regulates activity | 0.631 | The POZ domains of BCL-6 and several other POZ proteins interact with corepressors N-CoR and SMRT. | SIGNOR-252240 |
Q9P2Y5 | Q14457 | 2 | binding | up-regulates activity | 0.861 | UVRAG interacts with Beclin 1, leading to activation of autophagy and thereof inhibition of tumorigenesis. | SIGNOR-150825 |
Q9H000 | Q04206 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.341 | MKRN2 promotes p65 ubiquitination and degradation through RING finger domain. | SIGNOR-278591 |
Q13546 | Q9UHD2 | 2 | phosphorylation | up-regulates activity | 0.373 | Additionally, RIPK1-dependent hyper-phosphorylation of TBK1 in Casp8 Ripk3 cells occurred during MNV-1 infection (Figure 4F).|RIPK1 and its kinase activity were required to promote increased TBK1 phosphorylation in the absence of caspase-8 (Figure 3E), suggesting that RIPK1 may promote TBK1 activation. | SIGNOR-279278 |
P53350 | Q6PGQ7 | 2 | phosphorylation | down-regulates | 0.788 | Following cdk1-dependent recruitment, plk1 triggers hbora destruction by phosphorylating a recognition site for scf(beta-trcp). | SIGNOR-178154 |
Q9Y5B0 | Q96GX5 | 1 | dephosphorylation | down-regulates activity | 0.433 | Taken together, these data suggest that Fcp1 bound and dephosphorylated Gwl at S90 and S453, and possibly at other Cdk1 dependent sites, during mitosis exit and that Fcp1 catalyzed dephosphorylation lowered Gwl activity towards Ensa and ARPP19, allowing PP2A-B55 to autoactivate.|Together, these data indicate that Fcp1 ... | SIGNOR-276971 |
Q04206 | Q13547 | 2 | binding | down-regulates | 0.571 | Phosphorylation at thr505 by the chk1 inhibits rela transactivation and results in its increased association with hdac1. | SIGNOR-151425 |
P42345 | Q92544 | 2 | binding | down-regulates activity | 0.2 | TM9SF4 inhibited mTOR activity in HEK293 cells. Under nutrient starvation, TM9SF4 functions to facilitate mTOR inactivation, resulting in an enhanced autophagic flux, which serves to protect cells from apoptotic cell death. | SIGNOR-266703 |
P37840 | P34947 | 0 | phosphorylation | down-regulates activity | 0.636 | Grk5 phosphorylated ser-129 of alpha-synuclein at the plasma membrane and induced translocation of phosphorylated alpha-synuclein to the perikaryal area. Grk5-catalyzed phosphorylation also promoted the formation of soluble oligomers and aggregates of alpha-synuclein. | SIGNOR-149372 |
Q99683 | O14548 | 1 | phosphorylation | up-regulates activity | 0.2 | Phosphorylation of EB1 by ASK1 promotes the binding of EB1 to CLIP-170 and p150 glued. | SIGNOR-278341 |
P31749 | P10586 | 0 | dephosphorylation | down-regulates | 0.342 | Knock-down of lar by the l3 sirna probe markedly inhibited the insulin-stimulated increase in the phosphorylation of protein kinase b (pkb, also called akt) on serine 473 by >90% | SIGNOR-137246 |
P05771 | P56537 | 1 | phosphorylation | down-regulates activity | 0.307 | Our results show that release of eIF6 from 60S subunits may operate, in mammalian cells, through a RACK1–PKC betaII pathway. |Loading 60S subunits with eIF6 caused a dose-dependent translational block and impairment of 80S formation, which were reversed by expression of RACK1 and stimulation of PKC in vivo and in vitro... | SIGNOR-249245 |
P07202 | P01266 | 1 | catalytic activity | up-regulates activity | 0.505 | After transport through the apical membrane, I− is covalently bound to the tyrosyl residues of Tg by thyroid peroxidase (TPO). | SIGNOR-259914 |
Q6JBY9 | P52907 | 2 | binding | up-regulates | 0.667 | An important clue to the function of CapZIP and its phosphorylation came from the finding that it binds to the actin-capping protein CapZ (Figure 7A), and that cellular stresses trigger the dissociation of these two proteins (Figure 7B). Such an effect is presumably lost when CapZIP is phosphorylated and dissociates fr... | SIGNOR-263088 |
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