IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O43683 | Q5FBB7 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Bub1 phosphorylates Sgo1 in the vicinity of its APC/C degrons in vitro.|On the other hand, Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1 mediated chromosome removal of Sgo1. | SIGNOR-278915 |
Q99594 | P46937 | 2 | binding | up-regulates | 0.85 | When dephosphorylated, yap/taz enter nuclei and induce gene transcription by interacting with transcription factors tead14. | SIGNOR-201471 |
Q86YB8 | Q9BS26 | 2 | binding | up-regulates quantity by stabilization | 0.2 | Here, we report the functional characterization of a novel UPR-induced ER resident protein (ERp44) that forms mixed disulfides with both hEROs, as well as with partially unfolded Ig subunits. | SIGNOR-261048 |
Q15796 | P24941 | 0 | phosphorylation | down-regulates activity | 0.488 | Moreover, CDK2 is the predominant CDK that phosphorylates Smad2 on T8 in myeloma cells, leading to inhibition of Smad2-Smad4 association that precludes transcriptional regulation by Smad2.|Moreover, CDK2 is the predominant cyclin-dependent kinase that phosphorylates Smad2 on T8 in myeloma cells, leading to inhibition o... | SIGNOR-279678 |
P49841 | Q9Y5Q3 | 1 | phosphorylation | down-regulates | 0.2 | We showed that c-maf and mafb, like mafa, are indeed phosphorylated by gsk-3/ we demonstrated that phosphorylation by gsk-3 is conserved among the large maf proteins. It couples ubiquitination/degradation and transcriptional activation and modulates maf biological activity. | SIGNOR-159476 |
Q9Y2M5 | Q14457 | 2 | binding | down-regulates quantity by destabilization | 0.277 | Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination. KLHL20 promotes ubiquitination of phagophore-residing VPS34 and Beclin-1 | SIGNOR-272415 |
Q92823 | Q12955 | 1 | relocalization | up-regulates quantity | 0.721 | Neurofascin, L1, NrCAM, NgCAM, and neuroglian are membrane-spanning cell adhesion molecules with conserved cytoplasmic domains that are believed to play important roles in development of the nervous system. This report presents biochemical evidence that the cytoplasmic domains of these molecules associate directly with... | SIGNOR-266720 |
Q13351 | O95600 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.25 | Here we report that Klf8 is repressed by Klf3 in vivo and is up-regulated by Klf1. Transcript analysis indicates that Klf8 has two promoters, both containing multiple CACCC elements. Transactivation assays and chromatin immunoprecipitation experiments indicate that Klf3 represses Klf8 directly and that Klf1 activates K... | SIGNOR-266050 |
P24468 | P28702 | 2 | binding | up-regulates | 0.275 | Arp-1/rxr, coup-tfi/rxr, and arp-1/coup-tfi heterodimers bound the fp330-3' site. | SIGNOR-79452 |
P24941 | O43379 | 0 | relocalization | up-regulates activity | 0.244 | Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the centrosome, with CDK5RAP2 at the apex, and CEP152, WDR62 and CEP63 at seq... | SIGNOR-271726 |
P53355 | P04637 | 1 | phosphorylation | up-regulates | 0.558 | Dna damage-activated protein kinases like chk1/2 modify the box-i domain of p53 at thr18 and ser20 (46) by an allosteric mechanism (10). | SIGNOR-153491 |
P35568 | O14543 | 2 | binding | down-regulates | 0.74 | Irs-1 is the major signaling protein that socs3 targets to inhibit insulin signaling | SIGNOR-199361 |
Q5XPI4 | P83916 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | In the present study, we report that HP1α and β undergo proteasomal degradation in lamin A/C knock-down cells and show by ectopic expression, RNAi and binding studies that the RING finger ubiquitin ligase RNF123 is directly involved in HP1 degradation. | SIGNOR-272034 |
P28482 | Q15796 | 1 | phosphorylation | up-regulates | 0.722 | We show that phosphorylation of smad2, a mediator of the activin/transforming growth factor-beta signal, by activated extracellular signal-regulated kinase 1 (erk1) increases the amount of smad2 protein and leads to enhanced transcriptional activity. | SIGNOR-91714 |
P31749 | Q9Y3C5 | 1 | phosphorylation | down-regulates quantity | 0.456 | Upon inhibition of the AKT pathway or mutation of T135, the phosphorylation at one of these sites is virtually eliminated, suggesting that AKT may phosphorylate RNF11 at T135. Moreover, RNF11 is phosphorylated by AKT in vitro and is recognized by phospho-AKT substrate antibodies. RNF11 shows enhanced binding to 14-3-3 ... | SIGNOR-252558 |
P21860 | O14944 | 2 | binding | up-regulates | 0.591 | For example, betacellulin binds to and activates both erbb1 and erbb4, whereas epiregulin binds to erbb1, erbb3 and erbb4 | SIGNOR-191785 |
P61106 | Q96T51 | 1 | relocalization | up-regulates activity | 0.63 | Here, we have demonstrated that Rab14 interacts with RUFY1, previously identified as a Rab4 effector, and is required for RUFY1 recruitment onto endosomes and efficient recycling of Tfn. | SIGNOR-261279 |
Q76N32 | O95613 | 1 | relocalization | up-regulates activity | 0.34 | We also found that Cep68 forms a complex with Cep215 (also known as Cdk5Rap2) and PCNT (also known as pericentrin), two PCM (pericentriolar material) proteins involved in centriole engagement. |Cep68 stabilization increases the amount of PCNT at metaphase centrosomes, but does not affect its removal at the end of mitos... | SIGNOR-275623 |
P17252 | O14939 | 1 | phosphorylation | up-regulates | 0.692 | The phosphorylation sites in phospholipase d2 (pld2) induced by activation of protein kinase calpha (pkcalpha) in cos 7 cells were analyzed by mass spectrometry. Ser134, 146, and 243, and thr72, 99/100, and 252 were identified. These sites were mutated to ala and the double mutation of ser243 and thr252 eliminated the ... | SIGNOR-138355 |
Q9Y2I6 | P06493 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.422 | In this study, we show that Nlp can be phosphorylated by cell cycle protein kinase Cdc2/cyclin B1. The phosphorylation sites of Nlp are mapped at Ser185 and Ser589. the phosphorylation at the site Ser589 by Cdc2/cyclin B1 plays an important role in Nlp protein stability probably due to its effect on protein degradation... | SIGNOR-259831 |
P14778 | P45983 | 1 | phosphorylation | up-regulates activity | 0.379 | Il-1 binding to its receptor triggers a cascade of signaling events, including activation of the stress-activated mitogen-activated protein (map) kinases, c-jun nh2-terminal kinase (jnk) and p38 map kinase, as well as transcription factor nuclear factor kappab (nf-kappab | SIGNOR-249513 |
O14986 | P17252 | 0 | phosphorylation | down-regulates | 0.2 | Collaboration of ampk and pkc to induce phosphorylation of ser413 on pip5k1b resulting in decreased kinase activity and reduced ptdins(4,5)p2 synthesis in response to oxidative stress and energy restriction. we demonstrate that pkc can directly phosphorylate ser413 in vitro | SIGNOR-194820 |
P15880 | P0DTD1-PRO_0000449619 | 2 | binding | down-regulates activity | 0.2 | Nsp1 Locks the 40S in a Conformation Incompatible with mRNA Loading and Disrupts Initiation Factor Binding. Molecular interactions between C-Nsp1 and 40S ribosome components, including uS3, h18, and uS5. | SIGNOR-262508 |
P49711 | Q00341 | 2 | binding | up-regulates activity | 0.481 | Vigilin interacts with CCCTC-binding factor (CTCF) and is involved in CTCF-dependent regulation of the imprinted genes Igf2 and H19. vigilin is present at several known CTCF target sites, such as the promoter regions of c-myc and BRCA1, the locus control region of β-globin, and several regions within the Igf2/H19 locus... | SIGNOR-266693 |
Q9UI08 | Q70E73 | 2 | binding | up-regulates activity | 0.346 | Here we show that Lpd is a substrate of Abl kinases and binds to the Abl SH2 domain. Phosphorylation of Lpd positively regulates the interaction between Lpd and Ena/VASP proteins. | SIGNOR-268427 |
Q13976 | Q13507 | 1 | phosphorylation | down-regulates | 0.408 | The present study demonstrates that human trpc3 expressed in hek293 cells forms store-operated ca2+ influx channels, the activity of which is inhibited by pkg. The inhibition is due to a direct phosphorylation of pkg on trpc3 channels at position t11 and s263. | SIGNOR-142961 |
O15111 | P35222 | 1 | phosphorylation | up-regulates quantity | 0.485 | Interestingly, while IKK2 negatively regulates beta-catenin stability similar to GSK3beta, IKK1 seems to increase beta-catenin protein level and downstream signal, such as cyclin D1 transcription.|These results suggested IKK1 may phosphorylate beta-catenin at different residues and protect it from ubiquitination mediat... | SIGNOR-280230 |
P49841 | E9PAV3 | 1 | phosphorylation | down-regulates | 0.2 | Gsk3 beta-dependent phosphorylation of the alpha nac coactivator regulates its nuclear translocation and proteasome-mediated degradation. | SIGNOR-123262 |
Q9UBE8 | P40763 | 1 | phosphorylation | up-regulates | 0.347 | Phosphorylation of s727 induces pin1 binding which increases transcription. Pin1 binding increases stat3 interaction with p300 and dna. | SIGNOR-155828 |
O95229 | Q14457 | 2 | binding | up-regulates activity | 0.435 | We show that Beclin-1 interacts directly with Zwint-1-a component of the KMN (KNL-1/Mis12/Ndc80) complex-which is essential for kinetochore-microtubule interactions. This suggests that Beclin-1 acts downstream of the KMN complex to influence the recruitment of outer kinetochore proteins and promotes accurate kinetochor... | SIGNOR-265027 |
P61328 | Q9NY46 | 2 | binding | down-regulates activity | 0.235 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253444 |
Q15303 | P04626 | 2 | binding | up-regulates | 0.53 | Most breast, skin, lung, ovary, and gastrointestinal tract tumors express erbb-4, and heterodimerization of this receptor with erbb-2, may be involved in some cancer | SIGNOR-43844 |
Q12857 | Q14938 | 1 | transcriptional regulation | up-regulates quantity | 0.2 | We report that, in the absence of Nfia or Nfib, there is a marked reduction in the spinal cord expression of NFIX, and that NFIB can transcriptionally activate Nfix expression in vitro. These data demonstrate that NFIX is part of the downstream transcriptional program through which NFIA and NFIB coordinate gliogenesis ... | SIGNOR-268871 |
Q05655 | P29353 | 1 | phosphorylation | up-regulates | 0.569 | Pkc delta phosphorylates p52shca at ser29 to regulate erk activation in response to h2o2. | SIGNOR-149398 |
Q16659 | Q05923 | 0 | dephosphorylation | down-regulates activity | 0.376 | DUSP2 can dephosphorylate both ERK3 and ERK4 when expressed in mammalian cells.|Finally, we demonstrate that DUSP2 inhibits ERK3 and ERK4 mediated activation of MK5. | SIGNOR-277069 |
P29120 | P10997 | 1 | cleavage | up-regulates activity | 0.446 | The processing of proinsulin to insulin occurs in the secretory granules at the C-terminal end of pairs of basic amino acids, Arg31-Arg32 and Lys64-Arg65 [9,10]. Following cleavage, by the prohormone convertases, PC3 (also known as PC1) and PC2, the pair of basic amino acids are removed rapidly by carboxypeptidase E (C... | SIGNOR-261782 |
P49841 | O15273 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | GSK-3beta phosphorylates FBXL21 and TCAP to activate FBXL21-mediated, phosphodegron-dependent TCAP degradation.|These results show direct GSK-3beta phosphorylation of TCAP S157 and FBXL21 T33 sites. | SIGNOR-264852 |
Q13485 | P12755 | 2 | binding | down-regulates activity | 0.821 | The ski and snon protein family associate with and repress the activity of smad2, smad3, and smad4, three members of the tgf-fl signaling pathway | SIGNOR-236074 |
P12532 | P00519 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Here, we show that oncogenic HER2 tyrosine kinase signaling induces phosphorylation of mitochondrial creatine kinase 1 (MtCK1) on tyrosine 153 (Y153) in an ABL-dependent manner in breast cancer cells. Y153 phosphorylation, which is commonly upregulated in HER2+ breast cancers, stabilizes MtCK1 to increase the phosphocr... | SIGNOR-277406 |
P09471 | O43613 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257012 |
P05549 | P35318 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.267 | These findings suggest that NF-IL6 and AP-2 sites in the promoter region are the functional elements in the transcriptional regulation of human AM gene in vascular endothelial cells. | SIGNOR-254048 |
Q9NRD5 | P78348 | 1 | relocalization | up-regulates activity | 0.537 | we found that the PDZ domain-containing protein PICK1 (protein interacting with C kinase) interacts specifically with the C-termini of BNC1 and ASIC. Our studies showing association of recombinant PICK1 with ASIC and BNC1, and the presence of both PICK1 and ASIC in the synaptosomal fraction | SIGNOR-223417 |
P11274 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.601 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260526 |
Q14332 | Q92997 | 2 | binding | up-regulates activity | 0.641 | Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. | SIGNOR-258962 |
P15498 | P43405 | 2 | binding | up-regulates | 0.92 | Vav interacts with the tyrosine kinase syk | SIGNOR-107049 |
O60674 | P16410 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.445 | Janus Kinase 2 (Jak2) was directly associated with a box 1-like motif in the cytoplasmic tail of CTLA-4 molecule. Jak2 phosphorylated Y-165 residue in the cytoplasmic region of CTLA-4. It has been reported that phosphorylation and dephosphorylation of tyrosine residue Y-165 in the cytoplasmic region of CTLA-4 play an i... | SIGNOR-251346 |
Q9NZN1 | P62166 | 2 | binding | up-regulates activity | 0.595 | IL1 receptor accessory protein like, a protein involved in X-linked mental retardation, interacts with Neuronal Calcium Sensor-1 and regulates exocytosis. our data show that IL1RAPL interacts only with NCS-1 through its specific C-terminal domain. The functional relevance of IL1RAPL activity was further supported by th... | SIGNOR-263962 |
P05771 | Q16236 | 1 | phosphorylation | up-regulates | 0.418 | Phosphorylation of nrf2 at ser-40 by protein kinase c regulates antioxidant response element-mediated transcription / recently we reported evidence for the involvement of protein kinase c (pkc) in phosphorylating nrf2 and triggering its nuclear translocation in response to oxidative stress | SIGNOR-91830 |
P68400 | P08473 | 1 | phosphorylation | down-regulates | 0.323 | The cytoplasmic n-terminal domain of nep interacts with the phosphatase and tensin homologue deleted on chromosome 10 (pten) thereby regulating intracellular signaling via akt. Ser 6 is efficiently phosphorylated by protein kinase ck2. The phosphorylation of the cytoplasmic domain of nep inhibits its interaction with p... | SIGNOR-168673 |
Q9Y6B2 | Q92793 | 2 | binding | down-regulates activity | 0.406 | Here, we show that EID-1 is a potent inhibitor of differentiation and link this activity to its ability to inhibit p300 (and the highly related molecule, CREB-binding protein, or CBP) histone acetylation activity. | SIGNOR-253380 |
P17252 | O15530 | 0 | phosphorylation | up-regulates | 0.417 | One of the most studied events controlled by ptdins(3,4,5)p3, comprises the activation of a of agc family protein kinases, including isoforms of protein kinase b (pkb)/akt, p70 ribosomal s6 kinase (s6k), serum and glucocorticoid-induced protein kinase (sgk) and protein kinase c (pkc), which play crucial roles in regula... | SIGNOR-126066 |
P98161 | P53355 | 0 | phosphorylation | up-regulates activity | 0.2 | In addition, the tumor suppressor death-associated protein kinase phosphorylates and activates PKD1 in response to oxidative damage ( xref ). | SIGNOR-279985 |
Q6U7Q0 | Q01860 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assays revealed that Zfp322a binds to Pou5f1 and Nanog promoters and regulates their transcription. | SIGNOR-264900 |
P55957 | P67870 | 0 | phosphorylation | up-regulates activity | 0.286 | Here we report that Bid is phosphorylated by casein kinase I (CKI) and casein kinase II (CKII). Inhibition of CKI and CKII accelerated Fas-mediated apoptosis and Bid cleavage, whereas hyperactivity of the kinases delayed apoptosis. | These results suggest that residues S61, S64, and to a much lesser extent T58 are site... | SIGNOR-251054 |
P05412 | Q9NR30 | 2 | binding | up-regulates activity | 0.455 | C-Jun and RHII/Gu proteins interact in human cells at their endogenous level of expression. The helicase activity of RHII/Gu specifically facilitates c-Jun-mediated transcription. | SIGNOR-260977 |
P11802 | P42771 | 2 | binding | down-regulates | 0.905 | The first group, including p16ink4a, p15ink4b,p18ink4cand p19ink4d, is specific for the g1 cdks, cdk4 and cdk6, inhibiting the kinase activity of cyclin d/cdk4-cdk6 complexes on prb. | SIGNOR-44554 |
Q9NR28 | Q13490 | 2 | binding | down-regulates quantity | 0.895 | Smac promotes caspase-9 activation by binding to inhibitor of apoptosis proteins, IAPs, and removing their inhibitory activity. Smac is normally a mitochondrial protein but is released into the cytosol when cells undergo apoptosis. | SIGNOR-80206 |
O15297 | Q00987 | 1 | dephosphorylation | up-regulates | 0.681 | Wip1 interacts with and dephosphorylates mdm2 at serine 395, a site phosphorylated by the atm kinase. Dephosphorylated mdm2 has increased stability and affinity for p53, facilitating p53 ubiquitination and degradation. | SIGNOR-158328 |
P07288 | Q96ST3 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.2 | Chromatin immunoprecipitation (ChIP) and DNA affinity precipitation analysis demonstrated that Ebp1 and Sin3A associate at the PSA and E2F1 promoters. Functionally, Sin3A enhanced the ability of Ebp1 to repress transcription of androgen receptor (AR) and E2F1 regulated genes. | SIGNOR-253663 |
P35225 | P78552 | 2 | binding | up-regulates | 0.853 | It is now known that this alternate receptor is a heterodimer, the type ii il-4 receptor or the il-13 receptor, which is comprised of IL-4R And IL-13R1. | SIGNOR-100750 |
P26951 | O60674 | 2 | binding | up-regulates | 0.615 | Indeed, only upon fibronectin adhesion is janus kinase 2 (jak2) recruited to the beta1 integrin-il-3r complex and triggers il-3r beta common phosphorylation, leading to the formation of docking sites for activated stat5a. | SIGNOR-134859 |
P34897 | Q9NXA8 | 0 | post translational modification | down-regulates activity | 0.235 | Mitochondrial serine hydroxymethyl transferase (SHMT2) is a rate-limiting enzyme that catalyzes the catabolism of serine and drives the proliferation of osteosarcoma cells and colon cancer cells. SIRT5 directly mediates the desuccinylation of Lysine 280 on SHMT2. Therefore, SIRT5 is a candidate target to inhibit serine... | SIGNOR-267644 |
P08754 | P33032 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257183 |
P53350 | Q96T23 | 1 | phosphorylation | up-regulates activity | 0.352 | Moreover, CDK1 phosphorylates RSF1 at Ser1375, and this phosphorylation is necessary for PLK1 recruitment. Subsequently, PLK1 phosphorylates RSF1 at Ser1359, stabilizing PLK1 deposition. | SIGNOR-273590 |
Q9UHD2 | P42226 | 1 | phosphorylation | up-regulates | 0.674 | We now show that stat6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger sting (also named mita/eris) to recruit stat6 to the endoplasmic reticulum, leading to stat6 phosphorylation on ser(407) by tbk1 and tyr(641), independent of jaks. Phosphorylated s... | SIGNOR-176775 |
P53602 | P38646 | 2 | binding | down-regulates activity | 0.342 | Mortalin binds to mevalonate pyrophosphate decarboxyl ase in mammalian cell. Mot-2 inactivates MPD resulting in decreased amounts of the steady state Ras protein. | SIGNOR-265890 |
P49841 | P20807 | 0 | cleavage | up-regulates activity | 0.272 | Thus, it has been shown that calpain cleaves the inhibitory domain of GSK3 generating two fragments of 40 and 30 kDa. This cleavage enhanced activity of the kinase | SIGNOR-251607 |
O95382 | Q99683 | 2 | phosphorylation | up-regulates quantity by stabilization | 0.551 | ASK2 Activates ASK1 by Phosphorylation | SIGNOR-260832 |
P35711 | Q8IYA7 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.295 | MKX is a meniscus-enriched transcription factor. In human meniscus cells, MKX regulates the expression of meniscus marker genes, OA-related genes, and other transcription factors, including Scleraxis (SCX), SRY Box 5 (SOX5), and Runt domain-related transcription factor 2 (RUNX2). | SIGNOR-267214 |
P32754 | Q9BYT3 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. However, the regulation of HPD expression remains largely unknown. Here, we demonstrate that molecular chaperone TTC36, which is highly expressed in liver, is associated with HPD... | SIGNOR-272958 |
P00734 | P00742 | 0 | cleavage | up-regulates activity | 0.459 | The present data point to key roles of FVIII and FIX in FX activation at the site of a platelet thrombus by supporting: (i) thrombin generation, (ii) thrombus growth and platelet phosphatidylserine exposure, and (iii) fibrin formation at the platelet surface. The likely mechanism is that tenase activity via FVIIIa and ... | SIGNOR-263539 |
O95393 | P17813 | 2 | binding | up-regulates activity | 0.362 | Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. We found that mouse and human endoglin ECD-Fc bound directly, specifically, and with high affinity to bone morphogenetic proteins 9 and 10 (BMP9 and BMP10) in su... | SIGNOR-276657 |
P54821 | P11831 | 2 | binding | up-regulates | 0.442 | The human homeodomain proteinphox1interacts functionally with serum response factor (srf) to impart serum responsive transcriptional activity to srf-binding sites in a hela cell cotransfection assay. | SIGNOR-52657 |
O60936 | P49840 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | The present study provided evidence that GSK3alpha and beta directly phosphorylates Arc, resulting in its subsequent degradation. | SIGNOR-279179 |
P09471 | P41968 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257026 |
O15111 | Q9Y261 | 1 | phosphorylation | down-regulates | 0.2 | Here, we show that ikk_, an important downstream kinase of tnf_, interacts with and phosphorylates foxa2 at s107/s111, thereby suppressing foxa2 transactivation activity and leading to decreased numb expression | SIGNOR-195316 |
P10276 | Q9NPD5 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter. | SIGNOR-268989 |
P00533 | P42229 | 2 | binding | up-regulates | 0.821 | We identified stat5 as a direct binding partner to egfr and erbb4 and discovered new recognition motifs for shc and stat5.Egf stimulation and subsequent phosphorylation of egfr at tyrosine y978, y998 and y869 would then subsequently lead to recruitment and activation of stat5. | SIGNOR-68159 |
Q07955 | P61011 | 2 | binding | up-regulates activity | 0.299 | We have now demonstrated that p54 interacts not only with SC35 and ASF/SF2 but also with U2AF. Pairwise interactions between p54 and other RS domain-containing spliceosomal proteins in comparison with SC35 and ASF/SF2 as detected by the yeast two-hybrid interaction assay. . It is conceivable that p54 can mediate 59 and... | SIGNOR-261161 |
P23771 | P42226 | 0 | null | up-regulates | 0.662 | GATA-3 plays a central role in regulating Th1 and Th2 cell differentiation. Upon interleukin (IL)-4 binding to its receptor, GATA-3 is induced through the action of Stat6 | SIGNOR-254299 |
Q16778 | Q9HCI7 | 0 | monoubiquitination | down-regulates activity | 0.2 | MSL1/2 ubiquitylates histone H2B on K 34. Importantly, only mono-ubiquitylation of H2B by MSL1/2 was detected in cells (data not shown), suggesting that MSL1/2, like RNF20/RNF40, was mainly a mono-ubiquitylase under physiological conditions.the MOF-MSL complex functions to promote both H4 K16ac and H2B K34ub. H2B K34u... | SIGNOR-271976 |
Q9P2B4 | Q9NRL3 | 2 | binding | up-regulates activity | 0.666 | Although CTTNBP2 and CTTNBP2NL are different in terms of tissue and subcellular distribution, our data indicate that, similar to CTTNBP2NL, CTTNBP2 associates with members of the striatin family, namely striatin and zinedin. Moreover, CTTNBP2 is critical for the distribution of striatin and zinedin in dendritic spines.... | SIGNOR-261701 |
Q09472 | Q02078 | 2 | binding | up-regulates | 0.861 | Once released from associated repressors, MEF2 is bound by the p300 coactivator, which possesses histone acetyltransferase activity. Thus, the net result of CaMK signaling to MEF2 complexes is increased histone acetylation (Ac), which relaxes chromatin and stimulates MEF2 target gene transcription. | SIGNOR-232165 |
P10636 | Q00535 | 0 | phosphorylation | down-regulates activity | 0.763 | We found that cdk5 phosphorylated tau(441) at Thr-181, Ser-199, Ser-202, Thr-205, Thr-212, Ser-214, Thr-217, Thr-231, Ser-235, Ser-396, and Ser-404, but not at Ser-262, Ser-400, Thr-403, Ser-409, Ser-413, or Ser-422. GSK-3beta phosphorylated all the cdk5-catalyzed sites above except Ser-235. | SIGNOR-249321 |
P12931 | P25490 | 1 | phosphorylation | down-regulates activity | 0.284 | YY1 phosphorylation is mediated by Src family kinases. | SIGNOR-276940 |
P57764 | P49662 | 0 | cleavage | up-regulates activity | 0.647 | Co-expression of GSDMD with caspase-1, 4, 5 or 11 but not apoptotic caspases (caspase-2, 8 and 9) in 293T cells induced the same cleavage of GSDMD|inflammatory caspases specifically cleave GSDMD after the 272FLTD275 (or 273LLSD276) sequence | | SIGNOR-256417 |
O43303 | P0DP25 | 2 | binding | up-regulates activity | 0.328 | We report that CP110 interacts with two different Ca2+-binding proteins, calmodulin (CaM) and centrin, in vivo. our data demonstrate a functional role for CaM binding to CP110 and suggest that CP110 cooperates with CaM and centrin to regulate progression through cytokinesis. | SIGNOR-266348 |
O75553 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.2 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254697 |
P00519 | P56962 | 1 | phosphorylation | down-regulates activity | 0.2 | C-Abl was identified as one of the kinases, which phosphorylates syntaxin 17.Western blot shows phosphorylation of syntaxin 17 on Tyr-156 by overexpression and activation of c-Abl. A phospho-mimicking mutant (Y156E) of syntaxin 17 showed reduced interaction with COPI vesicles. These results suggest that tyrosine phosph... | SIGNOR-273538 |
Q9Y222 | P07996 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Notably, amphiregulin (Areg), thrombospondin-1 (Tsp-1), JunB, Egr1, adrenomedullin (Adm), Bcl-3 and methyl-CpG binding domain protein 1 (Mbd1) were downregulated in the lungs from Dmp1-null mice while Gas1 and Ect2 genes were upregulated. | SIGNOR-261587 |
P10275 | Q16512 | 0 | phosphorylation | up-regulates | 0.587 | Rho can sensitize the ar to low levels of circulating androgens by promoting the nuclear translocation of a transcriptional co-activator, fhl2 (four and a half lim domains 2), which binds ar, and by stimulating protein kinase n (pkn), which phosphorylates ar directly. | SIGNOR-152762 |
Q92530 | O95271 | 0 | ADP-ribosylation | down-regulates quantity by destabilization | 0.501 | We identify the ADP-ribosyltransferase tankyrase (TNKS) and the 19S assembly chaperones dp27 and dS5b as direct binding partners of the proteasome regulator PI31. TNKS-mediated ADP-ribosylation of PI31 drastically reduces its affinity for 20S proteasome alpha subunits to relieve 20S repression by PI31. | SIGNOR-263387 |
P06493 | O15287 | 1 | phosphorylation | up-regulates | 0.355 | S387a mutant abolished fancg fusion protein phosphorylation by cdc2. | SIGNOR-129061 |
Q92993 | P49841 | 0 | phosphorylation | up-regulates | 0.367 | We demonstrate that gsk-3 phosphorylates serine 86 of the p53-acetyltransferase tip60. A tip60(s86a) mutant was less active to induce p53 k120 acetylation, histone 4 acetylation, and expression of puma | SIGNOR-174049 |
Q15797 | Q9HCE7 | 0 | ubiquitination | down-regulates | 0.708 | Smurf1 and smurf2 are e3 ubiquitin ligases known to suppress tgf-beta signaling through degradation of smads and receptors for tgf-beta and bmps | SIGNOR-195660 |
Q96QP1 | Q96CG3 | 1 | phosphorylation | up-regulates activity | 0.247 | The authors proposed that binding of ADP-Hep caused a conformational change exposing the catalytic cleft and allowing for ALPK1 to phosphorylate and activate TIFA leading to downstream NF-kB activation. | SIGNOR-279789 |
O95352 | O94817 | 2 | binding | up-regulates | 0.937 | Analogous to ubiquitination, atg12 is conjugated to atg5 by atg7--an e1-like protein--and atg10--an e2-like protein. | SIGNOR-180132 |
P28482 | Q9UBS5 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | We found that, in addition to CaMKIIβ, also ERK1/2 is involved in the degradation pathway of GABAB receptors under physiological and ischemic conditions. In contrast to our previous view, CaMKIIβ does not appear to directly phosphorylate S867. Instead, the data support a mechanism in which CaMKIIβ activates ERK1/2, whi... | SIGNOR-277857 |
P67775 | Q00987 | 1 | dephosphorylation | up-regulates activity | 0.455 | cyclin G also binds in vivo and in vitro to Mdm2 and markedly stimulates the ability of PP2A to dephosphorylate Mdm2 at T216. Consistent with these data, cyclin G null cells have both Mdm2 that is hyperphosphorylated at T216 and markedly higher levels of p53 protein when compared to wild-type cells | SIGNOR-248636 |
O00141 | P08151 | 2 | binding | down-regulates | 0.2 | SGK1 is known to inhibit another intrinsic pathway, the Hedgehog pathway, through downregulation of SMO and the GLI transcription factor family | SIGNOR-251672 |
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