IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
O15164 | O43791 | 2 | binding | down-regulates quantity by destabilization | 0.337 | Here, we analyzed changes in the ubiquitin landscape induced by prostate cancer-associated mutations of SPOP, an E3 ubiquitin ligase substrate-binding protein. SPOP mutants impaired ubiquitylation of a subset of proteins in a dominant-negative fashion. Of these, DEK and TRIM24 emerged as effector substrates consistentl... | SIGNOR-272825 |
P00533 | P52735 | 2 | phosphorylation | up-regulates | 0.592 | To understand the mechanism of egf-dependent vav2 activation, we examined first the egf-dependent phosphorylation sites on vav2 and the nature of interaction of vav2 with the activated egf receptor. Based on our in vitro and in vivo data all three tyrosine residues (142, 159, and 172) in the n-terminal domain of vav2 c... | SIGNOR-95980 |
P49810 | P48730 | 0 | phosphorylation | up-regulates activity | 0.364 | In vitro the large hydrophilic loop of PS-2 between transmembrane domains 6 and 7 can be phosphorylated by casein kinase-1 (CK-1) and CK-2, but not by PKA or PKC. Quantitative analysis of in vitro phosphorylation demonstrates the presence of two phosphorylation sites for CK-1 and a single site for CK-2. A deletion anal... | SIGNOR-250802 |
P28482 | P24723 | 0 | phosphorylation | up-regulates activity | 0.506 | Protein kinase C-eta regulates Mcl-1 level via ERK1. knockdown of PKCη but not PKCα, -δ or -ε caused a significant decrease in ERK (extracellular signal-regulated kinase) phosphorylation. Knockdown of ERK1 but not ERK2 decreased Mcl-1 level, and the decrease in Mcl-1 caused by PKCη knockdown was restored by ERK1 overe... | SIGNOR-261910 |
O95837 | P33032 | 2 | binding | up-regulates activity | 0.268 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257393 |
Q9Y6N7 | Q12857 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | For example, within the NFI targetome, we identified 6 collagen genes, 13 genes encoding potassium channel or glutamate receptor subunits and a range of factors related to axon guidance (e.g. Slit1, Robo1, Epha4, Epha5, Epha8) | SIGNOR-268893 |
P62993 | P00533 | 2 | binding | up-regulates activity | 0.923 | Adaptor protein Grb2 binds phosphotyrosines in the epidermal growth factor (EGF) receptor (EGFR) and thereby links receptor activation to intracellular signaling cascades. | SIGNOR-267725 |
Q15796 | Q92831 | 0 | acetylation | up-regulates | 0.578 | We demonstrate that both smad2 and smad3 are acetylated by the coactivators p300 and cbp in a tgfbeta-dependent manner. Smad2 is also acetylated by p/caf. The acetylation of smad2 was significantly higher than that of smad3. Lys(19) in the mh1 domain was identified as the major acetylated residue in both the long and s... | SIGNOR-150273 |
P09919 | Q99062 | 2 | binding | up-regulates | 0.766 | The gcsf:gcsf-r complex formed a 2:2 stoichiometry by means of a cross-over interaction between the ig-like domains of gcsf-r and gcsf. the ig-like domain cross-over structure necessary for gcsf-r activation is consistent with previously reported thermodynamic and mutational analyses. | SIGNOR-144743 |
Q9UHD2 | P09769 | 0 | phosphorylation | down-regulates activity | 0.2 | The Src family kinases (SFKs) Lck, Hck, and Fgr directly phosphorylate TBK1 at Tyr354/394, to prevent TBK1 dimerization and activation. | SIGNOR-276725 |
P26678 | Q13976 | 0 | phosphorylation | up-regulates activity | 0.409 | Phosphorylation of PLB by PKA or cGKI at Ser 16 relieves the inhibition of SERCA2a and results in increased contractility through enhanced Ca 2+ i reuptake into the SR. | SIGNOR-279269 |
P46527 | P62258 | 2 | binding | down-regulates | 0.54 | 14-3-3_, 14-3-3_, and 14-3-3_ (but not 14-3-3_ and 14-3-3_) could form a complex with p27kip1 / we discovered that akt-mediated p27kip1phosphorylation directly induces p27kip1binding to 14-3-3 and cytoplasmic localization through phosphorylating the newly identified thr198residue. | SIGNOR-88297 |
Q05655 | O95466 | 1 | phosphorylation | up-regulates activity | 0.27 | PKC\u03b4 induces FMNL1 phosphorylation. | SIGNOR-279261 |
Q96G30 | Q01726 | 2 | binding | down-regulates activity | 0.491 | We report that MRAP and MRAP2 can interact with all 5 MCRs. This interaction results in MC2R surface expression and signaling. In contrast, MRAP and MRAP2 can reduce MC1R, MC3R, MC4R, and MC5R responsiveness to [Nle4,D-Phe7]alpha-melanocyte-stimulating hormone (NDP-MSH). MRAP and MRAP2 can reduce the surface expression... | SIGNOR-252365 |
O60858 | P31751 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | Here, we demonstrate that overexpression of RFP2 in cells induced apoptosis through proteasomal degradation of MDM2 and AKT. We observed that RFP2 formed a complex with MDM2, a negative regulator of the p53 tumor suppressor, and AKT, a regulator of apoptosis inhibition at the cellular level. Additionally, we found tha... | SIGNOR-271853 |
P26358 | Q16576 | 2 | binding | down-regulates activity | 0.571 | AMPK inhibited DNMT1 through phosphorylation of Ser730 in DNMT1 and Ser314 in RBBP7|association with RBBP7 could inhibit DNMT1 | SIGNOR-264785 |
P50542 | O75381 | 2 | binding | up-regulates activity | 0.929 | The peroxisomal docking complex is a key component of the import machinery for matrix proteins. The core protein of this complex, Pex14, is thought to represent the initial docking site for the import receptors Pex5 and Pex7. | SIGNOR-253027 |
P54253 | P31749 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.411 | Interaction of Ataxin-1 and 14-3-3 Requires Akt Phosphorylation at S776. 14-3-3 protein, a multifunctional regulatory molecule, mediates the neurotoxicity of ataxin-1 by binding to and stabilizing ataxin-1, thereby slowing its normal degradation. | SIGNOR-252561 |
P35222 | P55286 | 2 | binding | up-regulates activity | 0.678 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265870 |
P42336 | Q9UBI6 | 2 | binding | up-regulates | 0.4 | We show that pge2 stimulates colon cancer cell growth through its heterotrimeric guanine nucleotide-binding protein (g protein)coupled receptor, ep2, by a signaling route that involves the activation of phosphoinositide 3-kinase and the protein kinase akt by free g protein bg subunits and the direct association of the ... | SIGNOR-141795 |
P08311 | P55085 | 1 | cleavage | down-regulates activity | 0.526 | PAR1E and PAR2E (10 microM) were incubated in the presence of the different proteases | The enzymes were used at the following concentrations: 0.5 unit/mL thrombin, 2.5 nM trypsin, 20 nM plasmin, 20 nM cathepsin G, 20 nM elastase, 20 nM proteinase 3, and 2 units/mL calpain I and II|Protease-activated receptors (PARs) m... | SIGNOR-263585 |
P46937 | Q9UDY2 | 2 | binding | down-regulates | 0.519 | The Crumbs complex component AMOT co-localizes with MST1_ 2, LATS1_ 2 and YAP in a complex at the tight junction to control cell growth. Zona occludens-2 (ZO-2) in the tight junction, and a-catenin, b-catenin, or PTPN14 in the adherence junction, also bind to YAP_TAZ. | SIGNOR-230754 |
P13010 | P52945 | 2 | binding | down-regulates quantity by destabilization | 0.307 | The interaction of PDX-1 with Ku subunits and its phosphorylation on threonine 11 by the DNA-PK appear to be implicated in its degradation by the proteosome. | SIGNOR-225537 |
Q9BUB5 | Q13177 | 0 | phosphorylation | down-regulates activity | 0.42 | Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. When 293T cells are subjected to apoptotic induction by hydrogen peroxide, Mnk1 is phosphorylated at both Thr(22) and Ser(27). These results indicate a role for Pak2 in the down-regulation of translat... | SIGNOR-250221 |
O43432 | Q96NX5 | 0 | phosphorylation | up-regulates | 0.2 | Here we report that activity-dependent translational initiation in cultured rat hippocampal neurons is enhanced by camki-mediated phosphorylation of ser1156 in eukaryotic initiation factor eif4gii (4gii). | SIGNOR-197149 |
Q14586 | P09238 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.39 | Furthermore, ZNF267 binds to the MMP-10 promoter region as demonstrated by chromatin immunoprecipitation assays. In conclusion, our results suggest that ZNF267 as a negative transcriptional regulator of MMP-10 | SIGNOR-266211 |
P53350 | Q15022 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.362 | PLK1 and HOTAIR Accelerate Proteasomal Degradation of SUZ12 and ZNF198 during Hepatitis B Virus-Induced Liver Carcinogenesis|In SUZ12, residues 539, 541 and 546 phosphorylated by Plk1 in vitro | SIGNOR-275555 |
P49841 | P49770 | 2 | binding | down-regulates | 0.2 | Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). | SIGNOR-175475 |
Q9NZN5 | P50148 | 2 | binding | up-regulates activity | 0.419 | Leukemia-associated Rho guanine nucleotide exchange factor promotes G alpha q-coupled activation of RhoA. | SIGNOR-256520 |
P51946 | P49336 | 0 | phosphorylation | down-regulates | 0.645 | Cdk8 phosphorylates mammalian cyclin h in the vicinity of its functionally unique amino-terminal and carboxy-terminal alpha-helical domains. This phosphorylation represses both the ability of tfiih to activate transcription and its ctd kinase activity | SIGNOR-82033 |
Q86Y13 | P54253 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.483 | HOTAIR associates with E3 ubiquitin ligases bearing RNA-binding domains, Dzip3 and Mex3b, as well as with their respective ubiquitination substrates, Ataxin-1 and Snurportin-1. In this manner, HOTAIR facilitates the ubiquitination of Ataxin-1 by Dzip3 and Snurportin-1 by Mex3b in cells and in vitro, and accelerates the... | SIGNOR-272078 |
P31785 | P40933 | 2 | binding | up-regulates | 0.853 | The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, and il-15 as well as il-2. Here we show that the gamma(c) is also shared with the il-21r complex. | SIGNOR-108815 |
Q9UJU2 | P35222 | 2 | binding | up-regulates activity | 0.917 | Activated dvl binds and inhibits the phosphorylation of beta catenin by gsk3beta/alfa, blocking beta catenin degradation), so that beta catenin accumulates and translocates to the nucleus, where it interacts with the t cell specific factor (tcf)/lymphoid enhancer binding factor 1 (lef-1) transcription factor and induce... | SIGNOR-134219 |
Q13115 | P28482 | 1 | dephosphorylation | down-regulates activity | 0.762 | Dephosphorylation and Inactivation of ERKs|A single protein kinase, MEK, activates ERK2 by phosphorylating threonine 183 and tyrosine 185 | SIGNOR-248718 |
P06493 | P39880 | 1 | phosphorylation | down-regulates | 0.357 | Phosphorylation of serines 1237 and 1270 caused inhibition of dna binding in vitro. In cotransfection studies, cyclin a-cdk1 inhibited cdp/cux stable dna binding and prevented repression of the p21(waf1) reporter. | SIGNOR-110912 |
O43707 | Q05397 | 0 | phosphorylation | down-regulates | 0.558 | Phosphorylation at y12 by fak reduces _-actinin1's affinity for actin [25] and [27]. _-actinin4 is phosphorylated at y4, y31, and y265. Phosphorylation at y4 or y31 decreases its binding to actin [28] while phosphorylation of y265 increases its affinity for actin | SIGNOR-192195 |
Q15149 | Q9H3D4 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Here we show that in the developing skin, epidermal progenitor cells of mice lacking p63 transcription factor display alterations in the nuclear shape accompanied by a marked decrease in expression of several nuclear envelope-associated components (Lamin B1, Lamin A/C, Sun1, Nesprin-3, Plectin) compared with controls. ... | SIGNOR-263279 |
P48960 | P08174 | 2 | binding | up-regulates | 0.2 | This interaction may facilitate cell activation and migration through the blood-brain barrier. In addition, cd97-cd55 interactions in the parenchyma of the brain may contribute to the inflammation. | SIGNOR-95458 |
P68400 | Q9Y6K1 | 1 | phosphorylation | down-regulates activity | 0.2 | This modulation can be directly attributed to CK2-mediated phosphorylation of Dnmt3a. We also find that CK2-mediated phosphorylation is required for localization of Dnmt3a to heterochromatin. | SIGNOR-276650 |
P78347 | Q15853 | 2 | binding | up-regulates activity | 0.347 | TFII-I has been shown to interact with USF and to associate with either E-box elements or initiator sequences to activate gene transcription | SIGNOR-268537 |
P10645 | P08047 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Recently, binding of specific protein 1 (Sp1) and cAMP response element binding protein (CREB) to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells. Here we demonstrate that binding of early growth response pr... | SIGNOR-254273 |
Q12841 | Q14689 | 2 | binding | up-regulates activity | 0.48 | We identified DIP2A as a novel FSTL1-binding partner from the membrane fraction of endothelial cells. Co-immunoprecipitation assays revealed a direct physical interaction between FSTL1 and DIP2A. The work in the current study identifies DIP2A as a novel receptor for FSTL1 that mediates Akt activation and cell survival... | SIGNOR-266603 |
Q13216 | Q03468 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.582 | We have previously shown that CSA is a subunit of an E3 ubiquitin ligase complex. Here we demonstrate that CSB is a substrate of this ligase: Following UV irradiation, CSB is degraded at a late stage of the repair process in a proteasome- and CSA-dependent manner. | SIGNOR-271406 |
O95837 | Q9Y271 | 2 | binding | up-regulates activity | 0.385 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257135 |
Q13554 | P16949 | 1 | phosphorylation | down-regulates | 0.515 | Stimulation via cd2 activated multiple signal transduction pathways, resulting in phosphorylation of distinct sites of stathmin. Ser16 of recombinant human stathmin was phosphorylated also by purified cam kinase ii, and in vivo, cam kinase ii activity was indeed stimulated in cd2-triggered jurkat cells. | SIGNOR-59358 |
P42771 | P40424 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.308 | We show that the Pbx1 and Meis2 homeodomain proteins interact with Klf4 and can be recruited to DNA elements comprising a Klf4 site or G C box, with adjacent Meis and Pbx sites. Meis2d and Pbx1a activate expression of p15(Ink4a) and E-cadherin, dependent on the Meis2d transcriptional activation domain. We suggest a mod... | SIGNOR-267239 |
P53350 | O95425 | 1 | phosphorylation | up-regulates activity | 0.2 | PLK1 phosphorylates Ser238 of SVIL, which can promote the localization of SVIL to the central spindle and association with PRC1. Expression of a PLK1 phosphorylation site mutant, S238A-SVIL, inhibited myosin II activation at the equatorial cortex and induced aberrant furrowing. | SIGNOR-273729 |
O75925 | P15927 | 1 | sumoylation | up-regulates | 0.2 | Pias1 and pias4 promote brca1 accumulation and sumoylation, rpa phosphorylation, and dsb repair | SIGNOR-162153 |
P04035 | P13674 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this study, we found that the prolyl 4-hydroxylase (P4H) subunit P4HA1 protects NPC cells from erastin-induced ferroptosis by activating HMGCS1, a key enzyme in the mevalonate pathway. Our results show that HMGCS1 and HMGCR are regulated by P4HA subunits at the transcriptional level (Fig. S4). | SIGNOR-279854 |
P29803 | Q15118 | 0 | phosphorylation | down-regulates | 0.505 | Human pdh1 and rat pdh2 were expressed previously and were shown to have different specific activities and the ability to be phosphorylated by pdk1 and pdk2 | SIGNOR-143966 |
P54727 | P23760 | 2 | binding | down-regulates activity | 0.294 | Monoubiquitinated Pax3 was shuttled to the intrinsic proteasomal protein S5a by interacting specifically with the ubiquitin-binding protein Rad23B. | SIGNOR-237667 |
Q12888 | O15264 | 0 | phosphorylation | down-regulates activity | 0.2 | Here we show that 53BP1 is phosphorylated during mitosis on two residues, T1609 and S1618, located in its well-conserved ubiquitination-dependent recruitment (UDR) motif.|Dephosphorylation enables the recruitment of 53BP1 to double-strand DNA breaks |phosphorylation of T1609 is likely to be mediated by p38 MAPK | SIGNOR-264449 |
Q14185 | P00533 | 0 | phosphorylation | up-regulates activity | 0.308 | Here we report that EGFRvIII induces serine phosphorylation at serine residue 1250 (S1250) of Dock180 (p-Dock180 S1250 ) and that p-Dock180 S1250 is required for EGFRvIII-promoted Rac1 activation, glioblastoma cell growth, survival and invasion in vitro and in vivo .|We demonstrate that EGFRvIII induces serine phosphor... | SIGNOR-279329 |
Q03112 | Q02763 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | We finally observed that the forced expression of Evi1 induced GATA-2 expression in a hematopoietic cell line, EML C1, along with GATA-1, Ang-1, Ang-2 and Tie2 | SIGNOR-266063 |
P03372 | O14686 | 2 | binding | up-regulates | 0.454 | A novel estrogen receptor (er)alpha coactivator complex, the mll2 complex, which consists of mll2, ash2, rbq3, and wdr5, was identified / disrupting the interaction between eralpha and the mll2 complex with small interfering rnas specific against mll2 or an mll2 fragment representing the interacting region with eralpha... | SIGNOR-145865 |
P28482 | P46527 | 1 | phosphorylation | up-regulates | 0.346 | Phosphorylation on ser-10 of kip1 is the major site of phosphorylation in resting cells, takes place at the g(0)-g1 phase and leads to protein stability. | SIGNOR-77651 |
P18084 | Q9Y490 | 2 | binding | up-regulates activity | 0.589 | Over the past 10 years, the binding of talin to the cytoplasmic tail of integrin-β subunits has been established to have a key role in integrin activation. Binding of the phosphotyrosinebinding (PTB)-domain-like subdomain of the protein 4.1, ezrin, radixin, moesin (FERM) domain of talin to the conserved WxxxNP(I/L)Y mo... | SIGNOR-257629 |
P43405 | P22681 | 0 | ubiquitination | down-regulates quantity | 0.816 | Thus, c-Cbl specifically downregulates Syk levels in the presence of LMP2A.|c-Cbl promoted LMP2A degradation through ubiquitination, specifically degraded the Syk protein tyrosine kinase in the presence of LMP2A, and inhibited LMP2A induction of the EBV lytic cycle | SIGNOR-278689 |
Q00987 | P98177 | 1 | ubiquitination | down-regulates activity | 0.63 | Mdm2 Induces Mono-Ubiquitination of FOXO4.|higher amounts of Mdm2 transfected resulted in reduced FOXO4 transcriptional activity. | SIGNOR-278656 |
P05556 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.265 | PTPRG activation by the P1-WD peptide affected the tyrosine phosphorylation of several signaling molecules. Data analysis identified 31 molecules whose phosphorylation was modified in a statistically significant manner (Table I). inhibition of ABL1, BMX, BTK, DAB1, ITGB1, JAK2, KDR, KIT, LIMK1, MET, PDGFRB, SHC1, and V... | SIGNOR-254706 |
O60674 | P23470 | 0 | dephosphorylation | down-regulates activity | 0.287 | Deeper examination shows that JAKs are critically involved in integrin-mediated monocyte adhesion and that PTPRG activation leads to JAK2 dephosphorylation on the critical 1007–1008 phosphotyrosine residues, implying JAK2 inhibition and thus explaining the antiadhesive role of PTPRG. | SIGNOR-254690 |
Q14493 | Q16778 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265386 |
Q86T82 | Q01094 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | USP37 was induced by E2F transcription factors in G1|Ectopic E2F1 activated the wild-type promoter, but not the mutant promoter, 3-fold over basal levels in 293T cells (Figure 4F), confirming the functionality of the E2F binding sites in the USP37 promoter. | SIGNOR-265047 |
Q9H4A3 | O95198 | 2 | binding | down-regulates quantity by destabilization | 0.469 | We found that KLHL2, as well as KLHL3, was co-immunoprecipitated with all four WNK isoforms. The direct interaction of KLHL2 with WNKs was confirmed on fluorescence correlation spectroscopy. Co-expression of KLHL2 and Cullin3 decreased the abundance of WNK1, WNK3 and WNK4 within HEK293T cells, and a significant increas... | SIGNOR-272119 |
P38398 | P62136 | 0 | dephosphorylation | down-regulates activity | 0.377 | Protein kinases involved in the DNA damage checkpoint control, such as ATM, ATR, and hCds1/Chk2, have been shown to phosphorylate and activate BRCA1 upon DNA damage. |Altogether, these results indicate that PP1α specifically dephosphorylates BRCA1 at multiple serine sites, including S988 [12], S1423, and S1524. | SIGNOR-248560 |
P07948 | Q9Y6K9 | 1 | phosphorylation | down-regulates activity | 0.357 | Either IKKγ/NEMO WT or the Y374F mutant was coexpressed with each member of the Src family protein tyrosine kinases (SF-PTKs) in HEK 293T cells. Our study thus demonstrates that the Y374 or S377 residue located at the C-terminal proline-rich domain of human IKKγ/NEMO undergoes phosphorylation upon TNF-α treatment or Kv... | SIGNOR-276369 |
P63000 | Q7Z6B7 | 0 | gtpase-activating protein | down-regulates activity | 0.56 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260515 |
Q00987 | O43293 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.342 | Zip kinase was able to phosphorylate mdm2 at ser166, a site previously reported to be modified by akt kinase, thus demonstrating that zip kinase is a bona fide mdm2-binding protein. | SIGNOR-123159 |
P35398 | Q8IVA1 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | RORα regulates the expression of several genes in Purkinje cells. RORα becomes highly expressed in postmitotic Purkinje cells. It regulates their maturation, particularly dendritic differentiation. Dendritogenesis and the expression of several genes, including Shh, Itpr1, Pcp4, Calb1, Pcp2, and Slc1a6, normally express... | SIGNOR-266849 |
P08908 | Q6P1N0 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.371 | Akt kinase-interacting protein 1 (Aki1)/Freud-1/CC2D1A is localized in the cytosol, nucleus, and centrosome. Aki1 plays distinct roles depending on its localization. In the cytosol, it acts as a scaffold protein in the phosphoinositide 3-kinase (PI3K)/3-phosphoinositide-dependent protein kinase 1 (PDK1)/Akt pathway. In... | SIGNOR-268295 |
O14641 | Q14332 | 2 | binding | up-regulates activity | 0.65 | Upon ligand binding, DVL proteins are recruited to Frizzled receptors at the plasma membrane and co-recruit cytoplasmic transducers, such as Axin, CK1 and GSK3 binding protein (GBP), presumably along with their partners, to promote ?-catenin-dependent signalling. | SIGNOR-258959 |
P23469 | Q14721 | 1 | dephosphorylation | down-regulates activity | 0.355 | Hypomyelination and increased activity of voltage-gated K(+) channels in mice lacking protein tyrosine phosphatase epsilon | SIGNOR-248450 |
Q08050 | Q9H2X6 | 0 | phosphorylation | up-regulates activity | 0.2 | In conclusion, the phosphorylation of FOXM1 by HIPK2 can promote FOXM1 transcription activity and cell proliferation in RCC, thus, indicating a potential mechanism for the treatment of human RCC in the future. | SIGNOR-278944 |
P19174 | P38936 | 1 | phosphorylation | up-regulates quantity by stabilization | 0.262 | Phosphorylation at Ser-146 by PKCδ increases p21 stability | SIGNOR-262962 |
P49716 | P04150 | 0 | transcriptional regulation | up-regulates quantity | 0.315 | We conclude that glucocorticoid-induced adipogenesis from bone marrow stromal cells is mediated through a reaction cascade in which dexamethasone transcriptionally activates C/EBPδ; C/EBPδ then binds to PPARγ2 promoter and transactivates PPARγ2 gene expression. | SIGNOR-253061 |
Q9H0K1 | Q9BV73 | 1 | phosphorylation | down-regulates | 0.321 | Here, we show that the salt inducible kinase 2 (sik2) localizes at the centrosome, plays a key role in the initiation of mitosis, and regulates the localization of the centrosome linker protein, c-nap1, through s2392 phosphorylation | SIGNOR-167488 |
Q05195 | P23443 | 0 | phosphorylation | down-regulates | 0.304 | Both rsk and s6k phosphorylate serine 145 of mad1 upon serum or insulin stimulation. Ser-145 phosphorylation of mad1 accelerates the ubiquitination and degradation of mad1 through the 26s proteasome pathway, which in turn promotes the transcriptional activity of myc. | SIGNOR-178590 |
P08754 | P21728 | 2 | binding | up-regulates activity | 0.282 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257181 |
Q9UQM7 | P11831 | 1 | phosphorylation | up-regulates activity | 0.369 | Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. | Microsequencing of these phosphorylated peptides identified that both Ser-103 and a novel residue, Thr-160 in the MADS box of SRF, were sites of phosphorylation. | The location of Thr-160 in the 3-D structure of SRF s... | SIGNOR-250639 |
P57078 | O14641 | 1 | phosphorylation | up-regulates activity | 0.44 | Co-transfection of a RIPK4-GFP fusion increased the percentage of cells containing DVL2 puncta to more than 75% ( and ), suggesting that RIPK4 facilitates DVL2 signalosome formation.|Phosphorylation of DVL2 at Ser 298 and Ser 480 by RIPK4 favored canonical Wnt signaling. | SIGNOR-279756 |
Q9Y696 | Q00535 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | These results confirm that CDK5 phosphorylates CLIC4 at serine 108.|We found that activated CDK5 phosphorylated serine 108 in CLIC4, increasing CLIC4 protein stability, and accumulation. | SIGNOR-279451 |
P37231 | P00533 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.513 | Here, we found that nuclear EGFR induced phosphorylation of PPARγ at Tyr-74 leading to PPARγ ubiquitination and degradation by mouse double minute 2 (MDM2) ubiquitin ligase. | SIGNOR-277190 |
P04150 | P28482 | 0 | phosphorylation | down-regulates activity | 0.623 | Cyclin-dependent kinase (CDK) and mitogen-activated protein kinase (MAPK) phosphorylate the rat glucocorticoid receptor in vitro at distinct sites that together correspond to the major phosphorylated receptor residues observed in vivo; MAPK phosphorylates receptor residues threonine 171 and serine 246, whereas multiple... | SIGNOR-249428 |
Q14493 | Q7L7L0 | 1 | translation regulation | up-regulates quantity by expression | 0.2 | Synthesis of mature histone mRNA requires only a single processing reaction: an endonucleolytic cleavage between a conserved stem-loop and a purine-rich downstream element to form the 3' end. The stem-loop binding protein (SLBP) is required for processing, and following processing, histone mRNA is transported to the cy... | SIGNOR-265409 |
P61586 | Q13464 | 2 | binding | up-regulates activity | 0.81 | Planar cell polarity (pcp) signalling triggers activation of the small gtpases rhoa and rac1, which in turn activate rho kinase (rock) and jun-n-terminal kinase (jnk), respectively, leading to actin polymerization and microtubule stabilization. | SIGNOR-199542 |
P27361 | Q9UHA4 | 2 | binding | up-regulates | 0.606 | A protein called mp1 (mek partner 1) was identified that bound specifically to mek1 and erk1 and facilitated their activation. When overexpressed in cultured cells, mp1 enhanced activation of erk1 and activation of a reporter driven by the transcription factor elk-1. | SIGNOR-59877 |
P51955 | Q13188 | 0 | phosphorylation | up-regulates | 0.244 | Our data suggest that mst2 phosphorylates nek2a thereby recruiting nek2a to centrosomes and promoting phosphorylation and displacement of centrosomal linker proteins | SIGNOR-169539 |
P35222 | P49674 | 0 | phosphorylation | down-regulates activity | 0.657 | Using mass spectrometry and phosphopeptide-specific antibodies, we show that a complex of axin and casein kinase I (CKI) induces Beta-catenin phosphorylation at a single site: serine 45 (S45). | SIGNOR-244102 |
P45985 | O43379 | 0 | relocalization | up-regulates activity | 0.2 | In the WT brain, the WDR62 scaffold organizes a protein complex including MEKK3, MKK4/7, and JNK1 to control NPC development during corticogenesis | SIGNOR-271715 |
Q92830 | Q71DI3 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269601 |
Q13043 | O43561 | 1 | phosphorylation | up-regulates activity | 0.2 | MST kinase phosphorylates and activates LATS kinase. | SIGNOR-279661 |
P09471 | P08173 | 2 | binding | up-regulates activity | 0.373 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256965 |
P00533 | Q13671 | 2 | binding | up-regulates | 0.403 | The interaction between egfr and rin1 delineates a novel signal transduction pathway between egfr and its effectors, rin1, rab5a, and ras, which together coordinate and regulate both signaling and membrane trafficking. | SIGNOR-101530 |
P07550 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.352 | We investigate the role of the beta 2-adrenergic receptor phosphorylation by protein kinase C in this regulatory process. Mutation of the serine-261, -262, -344 and -345 of the beta 2-adrenergic receptor prevented the phorbol-ester-induced phosphorylation of the receptor. This mutation also abolished the phorbol-ester-... | SIGNOR-248855 |
O60216 | Q01196 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.283 | We observed that depletion of RAD21 (but not CTCF) enhanced RUNX1 transcription in human HL-60 myelocytic leukemia cells | SIGNOR-259973 |
P98170 | O43236 | 2 | ubiquitination | down-regulates quantity | 0.2 | Fig. 1 D revealed that co-transfection of ARTS and full length XIAP strongly reduces the levels of ARTS, while co-transfection of ARTS and XIAPdelRING does not change ARTS protein levels.|In this study we show that XIAP also promotes the ubiquitination and degradation of its antagonist ARTS. | SIGNOR-278801 |
Q9Y5Q3 | P35452 | 2 | binding | down-regulates activity | 0.378 | Hoxd12 and MHox, that interact with v-/c-Maf, using the phage display method. The Hox proteins also could associate with the other Maf protein family members, MafB, MafK, MafF, and MafG, but not with Jun and Fos. The Hox proteins negatively regulated the DNA binding, transactivation and cell-transforming abilities of M... | SIGNOR-221896 |
O14936 | Q8IZU9 | 2 | binding | up-regulates activity | 0.459 | A Missense De Novo Variant in the CASK-interactor KIRREL3 Gene Leading to Neurodevelopmental Disorder with Mild Cerebellar Hypoplasia. KIRREL3 is a gene important for the central nervous system development-in particular for the process of neuronal migration, axonal fasciculation, and synaptogenesis-and colocalizes and ... | SIGNOR-269078 |
P63092 | P47901 | 2 | binding | up-regulates activity | 0.44 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256791 |
Q9UJA2 | Q8NCQ5 | 2 | binding | down-regulates quantity by destabilization | 0.333 | Fbxo15 Targets CLS1 Protein for Ubiquitination and Degradation to Disrupt Mitochondrial Function. S. aureus infection induces expression of a kinase, PINK1, that phosphorylates an indispensable protein CLS1, which in turn triggers CLS1 ubiquitination and degradation by the F box protein (SCFFbxo15). | SIGNOR-272170 |
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