IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P00519 | P17676 | 1 | phosphorylation | up-regulates | 0.399 | The y79 amino acid residue of c/ebpbeta was phosphorylated by c-abl or arg. The phosphorylation of c/ebpbeta resulted in an increased c/ebpbeta stability and a potentiation of c/ebpbeta transcription activation activity in cells | SIGNOR-186423 |
Q8NEA6 | Q96J02 | 0 | ubiquitination | down-regulates quantity | 0.331 | Itch promotes proteolytic degradation of Glis3.|Since Itch interacts with and ubiquitinates Glis3, it was of interest to determine which regions were necessary for Itch directed degradation of Glis3. | SIGNOR-278653 |
P55072 | Q5VZV1 | 0 | methylation | up-regulates activity | 0.308 | We reveal that METTL21C trimethylates p97 on the Lys315 residue and found that loss of this modification reduced p97 hexamer formation and ATPase activity in vivo. | SIGNOR-255918 |
Q13485 | P63279 | 0 | sumoylation | up-regulates | 0.626 | The mh1 domain of smad4 was shown to associate physically with ubc9, the ubiquitin carrier protein (e2) conjugating enzyme in sumoylation. In cultured cells, smad4 is modified by sumo-1 at the endogenous level. The sumoylation sites were identified as two evolutionarily conserved lysine residues, lys-113 and lys-159, i... | SIGNOR-98997 |
P35240 | Q13188 | 2 | binding | up-regulates activity | 0.327 | NF2 is activated by oxidative stress in cardiomyocytes and mouse myocardium and facilitates apoptosis. NF2 promotes I/R injury through activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. | SIGNOR-261955 |
O15524 | P07947 | 0 | phosphorylation | up-regulates quantity by stabilization | 0.2 | Samples from human lymphomas that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylation of SOCS1 on Y80, and SOCS1 cytoplasmic localization. | SIGNOR-277453 |
Q9HBE5 | P23458 | 2 | binding | up-regulates | 0.628 | Retroviral-mediated transduction of wild-type gamma c into xscid jt cells restored function to the il-21r, as shown by il-21-induced tyrosine phosphorylation of jak1 and jak3, and downstream activation of stat5 | SIGNOR-90266 |
Q9BU19 | Q13131 | 0 | phosphorylation | down-regulates | 0.2 | Arebp is phosphorylated at ser(470) by ampk. Phosphorylation reduces the dna-binding activity of arebp. | SIGNOR-150590 |
P49760 | Q9UBK2 | 1 | phosphorylation | down-regulates activity | 0.2 | Clk2 could also repress PGC-1alpha activation of Foxo1 on the IRS response element , as well as repress the Pepck promoter .|Clk2 phosphorylates and represses PGC-1\u03b1. | SIGNOR-278228 |
P35579 | P35222 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.274 | Nuclear MYH9 bound to the CTNNB1 promoter through its DNA-binding domain, and interacted with myosin light chain 9, β-actin and RNA polymerase II to promote CTNNB1 transcription, which conferred resistance to anoikis in GC cells in vitro and in vivo. | SIGNOR-278896 |
P06241 | Q9ULL1 | 1 | phosphorylation | up-regulates activity | 0.2 | We also show that this activation of PLEKHG1 by FYN requires interaction between these two proteins and FYN-induced tyrosine phosphorylation of PLEKHG1 .|We also show that this activation of PLEKHG1 by FYN requires interaction between these two proteins and FYN-induced tyrosine phosphorylation of PLEKHG1. | SIGNOR-279988 |
O75143 | P42345 | 0 | phosphorylation | down-regulates | 0.651 | Mtor phosphorylates a mammalian homologue of atg13 and the mammalian atg1 homologues ulk1 and ulk2. | SIGNOR-183965 |
P29350 | P52333 | 1 | dephosphorylation | up-regulates | 0.688 | The expression of shp-1 protein was associated with dephosphorylation of the jak3 kinase. | SIGNOR-82764 |
P46821 | Q13618 | 0 | ubiquitination | down-regulates quantity | 0.254 | Gigaxonin is the substrate-specific adaptor for a new Cul3-E3-ubiquitin ligase family that promotes the proteasome dependent degradation of its partners MAP1B, MAP8 and tubulin cofactor B. | SIGNOR-268946 |
P49755 | P49768 | 2 | binding | up-regulates | 0.653 | Here we report that tmp21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage | SIGNOR-146364 |
Q9NYF5 | P63000 | 1 | gtpase-activating protein | down-regulates activity | 0.435 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260503 |
P33032 | O00253 | 2 | binding | down-regulates activity | 0.55 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268714 |
P51452 | P00533 | 1 | dephosphorylation | down-regulates activity | 0.357 | We found that EGF receptor (EGFR) was a direct substrate of VHR and that overexpression of VHR down-regulated EGFR phosphorylation, particularly at Tyr-992 residue. Expression of VHR inhibited the activation of phospholipase Cγ and protein kinase C, both downstream effectors of Tyr-992 phosphorylation of EGFR. | SIGNOR-248532 |
P12931 | O15492 | 1 | phosphorylation | up-regulates | 0.346 | Src-mediated rgs16 tyrosine phosphorylation promotes rgs16 stability. / this result suggests src phosphorylates native rgs16 at residue tyr177 in vitro. | SIGNOR-98271 |
Q8NER1 | Q00535 | 0 | phosphorylation | up-regulates activity | 0.2 | TNF-alpha overexpression increased Cdk5-mediated phosphorylation of TRPV1 at T407.|These results suggest that the activation of Cdk5 by p35 enhances the response of TRPV1 to capsaicin, probably by phosphorylation of the channel [34]. | SIGNOR-278437 |
A0PJZ3 | P46531 | 2 | binding | up-regulates | 0.382 | Recently, we have shown (28) that two members of the human glycosyltransferase 8 family (gt8) (29), gxylt1 and gxylt2 (glucoside-xylosyltransferase 1/2), are able to transfer the first alfa1,3-linked xylose to o-glucosylated mammalian notch egf repeats. | SIGNOR-177714 |
P18031 | Q9UKV8 | 1 | dephosphorylation | down-regulates activity | 0.2 | Taken together, our results indicate that Tyr 393 of AGO2 is hyperphosphorylated in response to PTP1B inactivation and may contribute to H-RAS V12 -induced development of senescence.|We identified phospho-Tyr 393 of argonaute 2 (AGO2) as a direct substrate of PTP1B. | SIGNOR-277120 |
P08754 | Q96RI0 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257157 |
P32245 | P63092 | 2 | binding | up-regulates activity | 0.521 | The melanocortin (MC) receptor family consists of five Gs-coupled receptors that control various physiological functions in response to four distinct agonists, adrenocorticotropic hormone (ACTH, also known as corticotrophin) and alpha, beta, and gamma melanocyte-stimulating hormone (MSH), which are derived from the pro... | SIGNOR-268707 |
P29323 | O43795 | 1 | phosphorylation | up-regulates activity | 0.2 | EphB2 kinase activity is required for Myo1b-EphB2 interaction and induced Myo1b phosphorylation. | SIGNOR-279171 |
P17813 | P12931 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.385 | We identified epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as Src-activators that induce endoglin turnover following (612)YIY(614) phosphorylation. | SIGNOR-276654 |
P35222 | P10721 | 0 | phosphorylation | up-regulates activity | 0.392 | These results suggest that active KIT can directly phosphorylate tyrosine residues of beta-catenin. | SIGNOR-278361 |
P04637 | Q9UNH5 | 0 | dephosphorylation | down-regulates activity | 0.401 | The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53|. Furthermore, the hCdc14 phosphatases were found to dephosphorylate p53 specifically at the p34Cdc2/clb phosphorylation site (p53-phosphor-Ser315)|Earlier studies showed that Ser315 phosphorylation increases the sequence-sp... | SIGNOR-248828 |
P28482 | Q9BQQ3 | 1 | phosphorylation | down-regulates activity | 0.27 | Here we show that GRASP65 is phosphorylated on serine 277 in interphase cells, and this is strongly enhanced in response to the addition of serum or epidermal growth factor. This is directly mediated by ERK suggesting that GRASP65 has some role in growth factor signal transduction. These results argue against Ser-277 p... | SIGNOR-262841 |
P55087 | P19784 | 0 | phosphorylation | down-regulates activity | 0.338 | We found that the stress-induced kinase casein kinase (CK)II phosphorylates the Ser276 immediately preceding the tyrosine motif, increasing AQP4-mu 3A interaction and enhancing AQP4-lysosomal targeting and degradation. | To determine whether Ser276 is an actual CKII substrate, we used GST–AQP4‐Cter proteins in which on... | SIGNOR-250976 |
P08575 | O60674 | 1 | dephosphorylation | down-regulates activity | 0.472 | Src homology-2 (SH2) containing tyrosine phosphatase and CD45 tyrosine phosphatase play a major role in modulating JAK-STAT pathway. SH2 containing tyrosine phosphatases include SHP1 and SHP2 (shatterproof 1 & 2). Their SH2 domains allow attachment to the phospho-tyrosine residues present on activated receptors, JAKs o... | SIGNOR-255679 |
P30679 | P41231 | 2 | binding | up-regulates activity | 0.408 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257031 |
Q96J02 | P49757 | 2 | binding | up-regulates | 0.615 | Numb activates the catalytic activity of itch, releasing it from an inhibitory intramolecular interaction between its homologous to e6-ap c-terminus and ww domains. | SIGNOR-167844 |
O75385 | Q13501 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.567 | ULK1 phosphorylates p62 at the Ser403 site. | SIGNOR-278349 |
P19174 | P17612 | 0 | phosphorylation | down-regulates | 0.2 | The observation that pka also phosphorylates plc-yl on serine 1248 suggests that phosphorylation of this residue may be a common mechanism by which pkc and pka inhibit plc-yl. | SIGNOR-17901 |
P11511 | P01100 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.346 | We found that both SF1 and LRH1 can transcriptionally cooperate with the AP-1 family members c-JUN and c-FOS, known to be associated with enhanced proliferation of endometrial carcinoma cells, to further enhance activation of the STAR, HSD3B2, and CYP19A1 PII promoters. | SIGNOR-254879 |
Q99743 | P20393 | 0 | transcriptional regulation | down-regulates quantity by repression | 0.631 | In this study, we found that NPAS2, like BMAL1, is a direct target gene of RORα and REV-ERBα. it appears in the context of the NPAS2 promoter RORα functions as a transcriptional activator, but REV-ERBα may only function as an inhibitor of RORα activity by blocking binding. | SIGNOR-267981 |
Q8NG66 | P51955 | 0 | phosphorylation | up-regulates | 0.393 | Nek2 directly phosphorylated nek11 in the c-terminal non-catalytic region and elevated nek11 kinase activity. | SIGNOR-124944 |
Q13618 | Q66K74 | 1 | ubiquitination | down-regulates quantity | 0.242 | Gigaxonin is the substrate-specific adaptor for a new Cul3-E3-ubiquitin ligase family that promotes the proteasome dependent degradation of its partners MAP1B, MAP8 and tubulin cofactor B. | SIGNOR-268947 |
Q99942 | Q7Z434 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.456 | In this study, we showed that the E3 ubiquitin ligase RING-finger protein 5 (RNF5) interacted with VISA at mitochondria in a viral infection-dependent manner. Domain mapping experiments indicated that the C-terminal transmembrane domain of VISA was required for its interaction with RNF5. RNF5 targeted VISA at K362 and ... | SIGNOR-271489 |
P48729 | P10071 | 1 | phosphorylation | down-regulates | 0.6 | In principle, pka, ck-1 and gsk3 can phosphorylate as many as 19 serine residues in gli3: fourpkasites, three primarygsk3sites, four primary ck-1 sites and eight secondary gsk3 and ck-1 sites | SIGNOR-116512 |
O60755 | P09471 | 2 | binding | up-regulates activity | 0.278 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256998 |
P49841 | Q9NX09 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.339 | It has been reported that GSK3beta phosphorylates REDD1 at residues Thr23 and Thr25, resulting in REDD1 recruitment to the Cullin 4a-beta-Trcp E3 ligase complex. | SIGNOR-279526 |
P78337 | P00519 | 0 | phosphorylation | up-regulates activity | 0.2 | Notably, c-Abl controls augmentation of Pitx1 at the post-transcriptional level.|Overexpression of c-Abl induces tyrosine phosphorylation of Pitx1, either directly or indirectly. | SIGNOR-280171 |
P63244 | P00519 | 0 | phosphorylation | up-regulates | 0.2 | Phosphorylation of rack1 on tyrosine 52 by c-abl is required for insulin-like growth factor i-mediated regulation of focal adhesion kinase.Tyrosine 52 is further shown to be phosphorylated by c-abl kinase, and the c-abl inhibitor sti571 disrupts fak interaction with rack1 | SIGNOR-185649 |
Q9UBE8 | O43318 | 0 | phosphorylation | up-regulates | 0.651 | The tak1-nlk-mapk-related pathway antagonizes signalling between beta-catenin and transcription factor tcf. | SIGNOR-96425 |
O60502 | P17858 | 1 | deglycosylation | up-regulates activity | 0.2 | Our previous investigation on O-GlcNAcylation of PFK1 has demonstrated that O-GlcNAcylation inhibits PFK1 enzyme activity|In cells, a single set of antagonistic enzymes-O-GlcNAc transferase (OGT) and O-GlcNAc hydrolase are responsible for the addition and removal of GlcNAc moiety, respectively. | SIGNOR-267608 |
Q9UIF3 | Q92949 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.324 | FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sp... | SIGNOR-266937 |
O60890 | P61586 | 1 | gtpase-activating protein | up-regulates activity | 0.636 | OPHN-1 colocalized with the actin cytoskeleton in neuronal and glial cells. We have previously shown that OPHN1 stimulates GTPases activity of RhoA, Cdc42, and Rac1 in vitro | SIGNOR-268397 |
P19086 | Q5NUL3 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257313 |
Q9UEW3 | Q86VS8 | 2 | binding | down-regulates | 0.2 | We have identified a microtubule-binding protein, hook3, as a novel interacting partner of sr-a. / by transfecting small interfering rna targeting hook3, total and surface expression, receptor-mediated ligand uptake and protein stability of sr-a were significantly promoted, whereas the protein synthesis and maturation ... | SIGNOR-152268 |
O60260 | Q9UNE7 | 2 | binding | up-regulates activity | 0.2 | In this study, we found that CHIP promotes Parkin-mediated Pael-R ubiquitination and subsequent degradation. In vitro ubiquitination assays suggested that only a combination of both Parkin and its cofactor CHIP function as a ubiquitin ligase, which is able to sufficiently ubiquitinate Pael-R in vivo (Figure 6). | SIGNOR-272888 |
P50148 | Q9HB89 | 2 | binding | up-regulates activity | 0.492 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256751 |
P49841 | P54132 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.259 | We now provide evidence that BLM undergoes K48-linked ubiquitylation and subsequent degradation during mitosis due to the E3 ligase, Fbw7α. Fbw7α carries out its function after GSK3β- and CDK2/cyclin A2-dependent phosphorylation events on Thr171 and Ser175 of BLM which lies within a well-defined phosphodegron, a sequen... | SIGNOR-276906 |
P49815 | Q15382 | 1 | gtpase-activating protein | down-regulates activity | 0.922 | Tsc2 functions as a gap to inhibit rheb activity. Tsc2 displays gap (gtpase-activating protein) activity specifically towards the small g protein rheb and inhibits its ability to stimulate the mtor signaling pathway. It has recently been shown that tsc2 has gtpase-activating protein (gap) activity towards the ras famil... | SIGNOR-128432 |
O14920 | Q05513 | 0 | phosphorylation | up-regulates activity | 0.517 | Activation of IkappaB kinase beta by protein kinase C isoforms. | Interestingly, recombinant active zetaPKC and alphaPKC are able to stimulate in vitro the activity of IKKbeta but not that of IKKalpha. In addition, evidence is presented here that recombinant zetaPKC directly phosphorylates IKKbeta in vitro, involving ... | SIGNOR-249015 |
P61586 | Q9Y4D1 | 2 | binding | up-regulates activity | 0.822 | B-catenin-independent wnt signaling can activate rho family gtpases through at least two mechanisms: (1) direct activation of rac1 by dvl;and (2) activation of rhoa via dvl-associated activator of morphogenesis-1 (daam1), possibly through the weak-similarity guaninenucleotide exchange factor (wgef)1. | SIGNOR-185268 |
P00533 | Q13555 | 0 | phosphorylation | down-regulates activity | 0.362 | The mechanism of desensitization of kinase activity can be accounted for, in part, by the EGF-stimulated phosphorylation of the receptor at Ser1046/7, a substrate for the multifunctional calmodulin-dependent protein kinase II in vitro. Mutation of Ser1046/7 by replacement with Ala residues blocks desensitization of the... | SIGNOR-250694 |
P35626 | P30411 | 1 | phosphorylation | down-regulates activity | 0.2 | Ligand-induced phosphorylation is found at Ser339 and Ser346/Ser348 that could be executed by several G protein-coupled receptor kinases. 32P labeling of peptide 3 containing pS346/pS348 was enhanced 1.5–3-fold as compared with mock-transfected cells in the order GRK6 < GRK5 < GRK2 < GRK4α < GRK3. several endogenous GR... | SIGNOR-251462 |
P13688 | Q13557 | 0 | phosphorylation | up-regulates | 0.2 | Camkiid specifically phosphorylates thr-457 on ceacam1-sf, which in turn regulates the process of lumen formation via apoptosis of the central acinar cells. | SIGNOR-203402 |
Q15596 | P04150 | 2 | binding | up-regulates activity | 0.839 | Here we report that GRIP1 loss in macrophages attenuates glucocorticoid induction of several anti-inflammatory targets, and that GC treatment of quiescent macrophages globally directs GRIP1 toward GR binding sites dominated by palindromic GC response elements (GRE), suggesting a non-redundant GRIP1 function as a GR coa... | SIGNOR-256095 |
Q16539 | P08151 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.27 | Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. | SIGNOR-277916 |
P17252 | P27987 | 1 | null | down-regulates activity | 0.359 | However, when assayed in the presence of calcium/calmodulin, the activity of the B isoform was decreased following phosphorylation by either protein kinase. | SIGNOR-248990 |
P53355 | P98161 | 1 | phosphorylation | up-regulates activity | 0.2 | In addition, the tumor suppressor death-associated protein kinase phosphorylates and activates PKD1 in response to oxidative damage ( xref ). | SIGNOR-279985 |
O95153 | Q9UQ26 | 2 | binding | down-regulates activity | 0.2 | SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. | SIGNOR-264368 |
P41208 | Q92949 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.353 | FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sp... | SIGNOR-266930 |
P19419 | P27361 | 0 | phosphorylation | up-regulates | 0.601 | Erki phosphorylates five c-terminal sites in elk-i (s324, t336, s383, s389 and s422) with varying degrees of efficiency. | SIGNOR-34669 |
Q96EB6 | Q09472 | 1 | deacetylation | down-regulates | 0.835 | Sirt1 induces deacetylation and repression of p300 itself (81). Mutational analysis demonstrated that sirt1 repression of p300 involves both lysine 1020 and lysine 1024 | SIGNOR-182511 |
P00533 | O14828 | 1 | phosphorylation | up-regulates activity | 0.399 | In our efforts to identify cellular tyrosine kinases that phosphorylate SCAMPs, we are quite intrigued by the observation that among a number of kinases, only the EGFR exhibits activity toward SCAMPs. EGF catalyzes the progressive phosphorylation of the SCAMPs up to 1 h poststimulation and may enhance colocalization of... | SIGNOR-262858 |
Q9UGL1 | Q16665 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.271 | To this end, we confirm that KDM3A, KDM4B, KDM4C, KDM5B, KDM5C, and KDM62 are direct targets of HIF-1a while extent the list of known targets to KDM2A, KDM2B, KDM4D, KDM5A, and KDM6A. The results demonstrated that majority of the KDMs were similarly induced (KDM2A, KDM2B, KDM3A, KDM4B, KDM4C, KDM4D, KDM5A, KDM5B, KDM5C... | SIGNOR-271563 |
P04637 | P33981 | 0 | phosphorylation | up-regulates | 0.499 | Ttk/hmps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at thr18. phosphorylation at thr18 enhances p53-dependent activation of not only p21 but also lats2, two mediators of the postmitotic checkpoint. | SIGNOR-184931 |
P17252 | P49840 | 1 | phosphorylation | down-regulates | 0.345 | Convergence of multiple signaling cascades at glycogen synthase kinase 3: edg receptor-mediated phosphorylation and inactivation by lysophosphatidic acid through a protein kinase c-dependent intracellular pathway. | SIGNOR-115714 |
Q05655 | P05787 | 1 | phosphorylation | up-regulates | 0.322 | The present study showed that shear stress, but not stretch, activates PKC delta and phosphorylates K8 Ser-73, which then mediates the disassembly/reorganization of keratin IF in AEC. | SIGNOR-260887 |
Q9H6Y7 | Q96BI1 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.525 | Here, we present evidences indicating that RING105, a novel conserved RING-finger protein with a PA (protease-associated) domain and a PEST sequence, is a ubiquitin ligase for TSSC5 that can function in concert with the ubiquitin-conjugating enzyme UbcH6. The polyubiquitin target site on TSSC5 was mapped to a region i... | SIGNOR-271551 |
Q09472 | Q13950 | 1 | acetylation | up-regulates quantity | 0.453 | Bmp-induced non-smad erk signaling pathway cooperatively regulates osteoblast differentiation, in part, through increasing the stability and transcriptional activity of runx2 or increasing runx2 acetylation by p300. | SIGNOR-195579 |
Q06830 | Q00534 | 0 | phosphorylation | down-regulates | 0.2 | Peroxiredoxin (prx) i is a member of the peroxiredoxin family of peroxidases and contains a consensus site (thr(90)-pro-lys-lys) for phosphorylation by cyclin-dependent kinases (cdks). This protein has now been shown to be phosphorylated specifically on thr(90) by several cdks, including cdc2, in vitro. Phosphorylation... | SIGNOR-87113 |
Q05513 | Q04206 | 1 | phosphorylation | up-regulates | 0.555 | Rela is phosphorylated at: ser276 by the catalytic subunit of protein kinase a (pkac), msk1 and msk2; at ser311 by the atypical pkczeta; at ser468 by ikkbeta, ikkepsilon and glycogen-synthase kinase-3beta (gsk3beta); at ser529 by ck2; and at ser536 by ikkbeta, ikkalfa, ikkepsilon, nf-kb activating kinase (nak, also kno... | SIGNOR-151432 |
Q03113 | Q92633 | 2 | binding | up-regulates | 0.46 | Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphophate (S1P) act through G12/13-coupled receptors to inhibit the Hippo pathway kinases Lats1/2, thereby activating YAP and TAZ transcription. | SIGNOR-198507 |
Q9ULB5 | P35222 | 2 | binding | up-regulates activity | 0.568 | At its C-terminus, cadherin interacts with β-catenin, which dynamically associates with α-catenin, a direct binding partner of filamentous actin | SIGNOR-265869 |
P23528 | P53671 | 0 | phosphorylation | down-regulates activity | 0.766 | We report here that limk1 and limk2 phosphorylate both cofilin and actin-depolymerizing factor (adf) specifically at ser-3 and exhibit partially distinct substrate specificity when tested using site-directed cofilin mutants as substrates | SIGNOR-105098 |
O00329 | P01116 | 2 | binding | up-regulates | 0.633 | Grb2 binds and activates sos, which then activates ras, and this activates p110 independently of p85./it was also described that ras interacts with pi3k in a direct manner./lysine residue 227 is essential for the interaction of ras with pi3k | SIGNOR-175210 |
Q15672 | Q9UGI0 | 0 | deubiquitination | down-regulates activity | 0.331 | Trabid inhibits Twist1 activity by cleaving RNF8-mediated Twist1 K63-linked ubiquitination | SIGNOR-273502 |
P19022 | P12931 | 0 | phosphorylation | down-regulates | 0.397 | Src-mediated phosphorylation of the n-cadherin cytoplasmic domain results in a significant reduction in beta-catenin bindingbeta-catenin dissociates from n-cadherin and redistributes to the nucleus of transmigrating melanoma cells to activate gene transcription.Because there were only four tyrosine residues (y852, y860... | SIGNOR-143242 |
O15075 | Q6ZN28 | 1 | phosphorylation | up-regulates activity | 0.2 | Subsequently, MACC1 gets phosphorylated by DCLK1.|This might be attributed to the higher activation of MACC1 by DCLK1 in the MACC1-positive cell lines SW620/Control and SW480/MACC1 used in this study. | SIGNOR-279031 |
Q6ZVD7 | Q9UHC6 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.2 | In this study we performed chromatin immunoprecipitation coupled to shotgun cloning to discover novel STOX1A target genes. Our results show that CNTNAP2, a member of the neurexin family, is directly downregulated by STOX1A. | SIGNOR-269065 |
Q92831 | P78527 | 0 | phosphorylation | up-regulates activity | 0.417 | In response to UV-induced DNA damage, DNA-PK phosphorylates and activates PCAF, and activated PCAF is transferred to photo lesion sites and further acetylates RPA1 at K163. | SIGNOR-280092 |
Q9UJZ1 | P43403 | 2 | binding | up-regulates activity | 0.2 | In these studies, we also found that SLP-2 interacted with Lck, ZAP70, LAT, and PLC-gamma1 during the 30-min period following stimulation in vitro|The SLP-2-associated pool of these molecules became phosphorylated/activated in a sequential manner, a profile compatible with their temporal involvement in early TCR signal... | SIGNOR-260377 |
Q14247 | Q9P2B4 | 2 | binding | up-regulates activity | 0.357 | CTTNBP2NL interacts with cortactin and targets cortactin to stress fibers. | SIGNOR-261695 |
Q5JR12 | P45984 | 0 | phosphorylation | down-regulates | 0.2 | Specific phosphorylation of pp2czeta at ser (92) by stress-activated jnk attenuates its phosphatase activity in cells. | SIGNOR-178934 |
P06241 | P20916 | 1 | phosphorylation | up-regulates activity | 0.425 | Fyn constitutively binds to MAG in a latent form. Ligand stimulation of L-MAG would result in activation of Fyn kinase and phosphorylation of Tyr-620. Binding and activation of PLC y through this phosphotyrosine residue would contribute to the signaling pathway involved in the regulation of myelination. | SIGNOR-251178 |
Q12955 | P12830 | 2 | binding | up-regulates activity | 0.323 | Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. Ankyrin-G also recruits beta-2-spectrin to E-cadherin-beta-catenin complexes, thus providing a direct connection between E-cadherin and the spectrin/actin skeleton. | SIGNOR-266710 |
Q13257 | P33981 | 0 | phosphorylation | up-regulates activity | 0.713 | Mps1 is an upstream component of the spindle assembly checkpoint, which, in human cells, is required for checkpoint activation in response to spindle damage but not apparently during an unperturbed mitosis. Mps1 also recruits Mad1 and Mad2 to kinetochores.|Thus, in human cells, Mps1 catalytic activity is required for s... | SIGNOR-252036 |
Q05655 | Q5JVS0 | 1 | phosphorylation | down-regulates activity | 0.29 | We found a strong phosphorylation of Ki-1/57 by PKCalphabeta, PKCdelta, PKClambda/zeta, and especially by PKCsigma, however not by PKCmi. These data show that Ki-1/57 can serve in principal as a substrate for a wide variety of different PKC isoforms but also that its phosphorylation is strongest with PKCsigma. | This s... | SIGNOR-249254 |
Q96GD4 | O14578 | 1 | phosphorylation | down-regulates activity | 0.283 | Finally, Aurora B phosphorylates CIT-K to control its localization and interaction with central spindle partners.|Together these findings indicate that CIT-K is an Aurora B substrate and that Aurora B phosphorylation at S699 dampens the association of CIT-K with KIF23 and the chromosomal passenger complex in order to r... | SIGNOR-279140 |
P42229 | O14543 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.637 | We have also found SOCS2 and SOCS3 specifically induced in 32D/Flt3-ITD, both of which are STAT3/5 target genes and known negative regulators of receptor signaling | SIGNOR-261548 |
P48664 | Q03135 | 2 | binding | down-regulates activity | 0.2 | EAAT3 has previously been shown to form complexes with caveolin-1, a major component of caveolae, which participate in the regulation of transport proteins. The present study explored the impact of caveolin-1 on electrogenic transport by excitatory amino acid transporter isoforms EAAT1-4. caveolin-1 is a powerful negat... | SIGNOR-264810 |
Q92900 | P31751 | 0 | phosphorylation | up-regulates activity | 0.2 | AKT-Mediated UPF1 Phosphorylation at T151 Promotes UPF1 Helicase Activity | SIGNOR-277595 |
Q13131 | Q86TI0 | 1 | phosphorylation | down-regulates | 0.425 | In rat l6 myotubes, endogenous tbc1d1 is strongly phosphorylated on ser237 and binds to 14-3-3s in response to the ampk activators aicar | SIGNOR-159048 |
P49815 | P49841 | 0 | phosphorylation | up-regulates activity | 0.731 | Gsk3 inhibits the mtor pathway by phosphorylating tsc2 in a manner dependent on ampk-priming phosphorylation. | SIGNOR-149380 |
P19086 | Q08828 | 2 | binding | down-regulates activity | 0.467 | Activated a z inhibits the activity of type I and type V adenylyl cyclases. | SIGNOR-278044 |
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