IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q12800 | P67775 | 0 | dephosphorylation | up-regulates | 0.2 | We previously established that phosphorylation of lsf in early g1 at ser-291 and ser-309 inhibits its transcriptional activity and that dephosphorylation later in g1 is required for its reactivation. This predominant cis conformation would also limit dephosphorylation of ser-291 and ser-309 by phosphatases such as pp2a | SIGNOR-167385 |
O60603 | Q99836 | 2 | binding | up-regulates activity | 0.673 | To initiate the innate immune response, Toll-like receptors (TLRs) associate with cytoplasmic adaptor proteins through TIR (Toll/interleukin-1 receptor) domain interactions. The four principal signaling adaptor proteins include MyD88, MAL, TRIF and TRAM, and the fifth protein SARM, involved in negative regulation of TL... | SIGNOR-266740 |
P04083 | P17252 | 0 | phosphorylation | up-regulates | 0.2 | The authors identified several phosphorylated residues by a combination of peptide mapping and sequence analysis and showed that recombinant pp60c-src phosphorylates annexin a1 near its amino terminus, at tyrosine 21 (tyr21). Also polyoma virus middle t/pp60c-src complex, recombinant pp50v-abl, and the egf receptor/kin... | SIGNOR-202780 |
P26358 | Q9H9S0 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.432 | Oct4 and Nanog upregulate Dnmt1 through direct binding to its promoter, thereby leading to the repressed expression of p16 and p21 and genes associated with development and lineage differentiation | SIGNOR-253157 |
P04629 | P29350 | 0 | dephosphorylation | down-regulates activity | 0.476 | Here, we identify SHP-1 as a phosphotyrosine phosphatase that negatively regulates TrkA. SHP-1 formed complexes with TrkA at Y490, and dephosphorylated it at Y674/675. | SIGNOR-248468 |
Q9NRJ5 | Q96HN2 | 2 | binding | down-regulates activity | 0.2 | Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation|In addition to CPSF, IRBIT interacted in vitro with poly(A) polymerase (PAP), which is ... | SIGNOR-268332 |
Q03113 | O43613 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257404 |
Q96F24 | P42345 | 0 | phosphorylation | up-regulates activity | 0.2 | Human NRBF2 is phosphorylated by MTORC1 at S113 and S120. Upon nutrient starvation or MTORC1 inhibition, NRBF2 phosphorylation is diminished. Phosphorylated NRBF2 preferentially interacts with PIK3C3/PIK3R4. Suppression of NRBF2 phosphorylation by MTORC1 inhibition alters its binding preference from PIK3C3/PIK3R4 to AT... | SIGNOR-265875 |
P63092 | P21728 | 2 | binding | up-regulates activity | 0.498 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256796 |
Q5S007 | P37840 | 1 | phosphorylation | down-regulates activity | 0.624 | Here we show that full-length Lrrk2 or fragments containing its kinase domain have a significant capacity to phosphorylate recombinant alpha synuclein (Asyn) at serine 129. Such phosphorylated Asyn is the major component of pathological deposits in PD. | SIGNOR-249690 |
Q8WVD3 | Q13315 | 0 | phosphorylation | up-regulates activity | 0.2 | We further confirm that RNF138 is phosphorylated by ATM at Ser124. | SIGNOR-279505 |
Q13114 | Q96RJ3 | 2 | binding | down-regulates quantity by destabilization | 0.758 | Activation of br3 induces recruitment and degradation of traf3. | SIGNOR-168199 |
Q9Y4K3 | Q9Y4K3 | 2 | ubiquitination | up-regulates activity | 0.2 | Here we report that the ubiquitin ligase (e3) traf6 interacts with a consensus motif present in tbetari. The tbetari-traf6 interaction is required for tgf-beta-induced autoubiquitylation of traf6 and subsequent activation of the tak1-p38/jnk pathway, which leads to apoptosis. | SIGNOR-180562 |
P28482 | Q13153 | 1 | phosphorylation | down-regulates activity | 0.402 | We also show that ERK2 phosphorylates PAK1 on Thr(212) in vitro and that Thr(212) is phosphorylated in smooth muscle cells following PDGF-BB treatment in an adhesion- and MEK/ERK-dependent fashion. Expression of a phosphomimic variant, PAK-T212E, does not alter ERK association, but markedly attenuates downstream ERK si... | SIGNOR-249432 |
P16519 | P01178-PRO_0000020496 | 1 | cleavage | up-regulates quantity | 0.2 | Oxytocin-extended form is further cleaved by enzymatic activity to yield the nine-amino-acid active peptide, OT. The proteolysis may involve several pro-hormone convertases, convertase 2 (PC2) (20p11-1-11.2) and convertase 5 (PC5) (9q21.3) (Gabreels et al 1998). Both enzymes are found in OT neurosecretory vesicles and ... | SIGNOR-270337 |
Q02750 | Q9Y2U5 | 0 | phosphorylation | up-regulates | 0.414 | Both mekk2 and mekk3 are able to activate the jun kinase pathway in vivo. However, following routine immunoprecipitation in triton x-100, mekk2 but not mekk3 is able to effectively phosphorylate both sek-1 and mek-1 and to undergo autophosphorylation | SIGNOR-107692 |
P08138 | P01138 | 2 | binding | up-regulates | 0.836 | The low affinity neurotrophin receptor p75ntr can mediate cell survival as well as cell death of neural cells by ngf and other neurotrophins. | SIGNOR-76832 |
Q07817 | Q07812 | 2 | binding | down-regulates | 0.745 | The presence of an anti-apoptotic molecule such as bcl-2 or bcl-xl can inhibit the activation of bax following a death signal. | SIGNOR-59141 |
Q8NG27 | P15172 | 0 | transcriptional regulation | up-regulates quantity | 0.2 | ... chromatin immunoprecipitation (ChIP) analysis showed MYOD binds to a site upstream the Pja1 promoter preferentially in C2C12 cells induced to differentiate (Fig. 2c). In addition, over-expression of MyoD in human fibroblasts is sufficient to up-regulate Pja1 expression | SIGNOR-255718 |
P54764 | P20827 | 2 | binding | up-regulates | 0.823 | Receptors of the epha group preferentially interact with glycosylphosphatidylinositol (gpi)-linked ligands (of the ephrin-a subclass, which comprises five ligands), while receptors of the ephb group preferentially interact with transmembrane ligands (of the ephrin-b subclass, which comprises three ligands) (table 1). I... | SIGNOR-52087 |
O95835 | Q16635 | 1 | phosphorylation | down-regulates activity | 0.387 | When the inhibitory Hippo kinase module is ' on ', LATS1 and LATS2 phosphorylate and inactivate YAP and TAZ, and the output gene production is therefore turned off.|When the inhibitory Hippo kinase module is \u2018on\u2019, LATS1 and LATS2 phosphorylate and inactivate YAP and TAZ, and the output gene production is ther... | SIGNOR-279200 |
P27361 | P05976 | 1 | phosphorylation | up-regulates | 0.287 | Activation of raf/mek/erk cascade can also result in the phosphorylation of the antiapoptotic mcl-1 protein and the pro-apoptotic bim protein. | SIGNOR-148002 |
Q15759 | Q06413 | 1 | phosphorylation | up-regulates activity | 0.538 | In this study, we demonstrate that among the different Mitogen-activated protein kinases, the MADS-box transcription factors MEF2A and MEF2C are preferentially phosphorylated and activated by the p38 subfamily members p38alpha and p38beta2. | SIGNOR-280025 |
P35222 | O60907 | 2 | binding | up-regulates activity | 0.659 | TBL1 appears to serve two roles in regulating the activity of β-catenin. Besides the initially identified role of TBL1 in recruiting β-catenin to the SCF(TBL1) complex, it has also been shown to function as a transcriptional co-activator of β-catenin in recruiting it to the promoter site of Wnt target genes. Our result... | SIGNOR-271954 |
O00418 | O15264 | 0 | phosphorylation | down-regulates activity | 0.578 | eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. eEF2K[S359A] was phosphorylated (presumably at Ser396) by the high concentrations of SAPK4/p38 used in this experiment. However, the inhibition of eEF2K under these conditions was reduced from 82% in the wild-type enzyme to 19% in eEF2K[S359A] | SIGNOR-250089 |
O15264 | Q6JBY9 | 1 | phosphorylation | down-regulates activity | 0.419 | CapZIP was also phosphorylated rapidly by SAPK3/p38γ and SAPK4/p38δ, and even faster and more extensively by JNK1α1, these protein kinases phosphorylating CapZIP in vitro to >3, approx. 2 and >5 mol of phosphate/mol of protein respectively within a few minutes. Following tryptic digestion and C18 chromatography, furthe... | SIGNOR-263084 |
P16104 | Q99504 | 0 | dephosphorylation | down-regulates | 0.2 | Tyr142 is dephosphorylated by the tyr phosphatases eya1 and eya3. | SIGNOR-168927 |
P54646 | Q13085 | 1 | phosphorylation | down-regulates | 0.697 | Significant negative linear correlations between phospho-acc and acc activity were observed in all models (p < 0.01). The decline in acc activity was related to the decrease in pcr and the rise in amp. A relationship between phospho-ampk (threonine 172) and activity of ampk immunoprecipitated with anti-alpha(2) subunit... | SIGNOR-87583 |
Q13561 | O43264 | 0 | relocalization | up-regulates activity | 0.685 | ZW10 interacts with dynamitin, a subunit of the dynein-dynactin complex (Echeverri et al., 1996), thereby recruiting this motor to kinetochores | SIGNOR-265016 |
Q9BYB0 | Q9P1A6 | 0 | relocalization | up-regulates activity | 0.2 | SHANK proteins are ‘master’ scaffolding proteins that tether and organize intermediate scaffolding proteins. They are located at excitatory synapses, where they are crucial for proper synaptic development and function. SAPAP proteins subsequently bind to the PDZ domain of members of the SHANK protein family. SHANK prot... | SIGNOR-264591 |
P34925 | O14640 | 2 | binding | up-regulates | 0.483 | Ryk also binds to dishevelled, through which it activates the canonical wnt, providing a link between wnt and dishevelled. | SIGNOR-129568 |
Q13459 | P60953 | 1 | gtpase-activating protein | down-regulates activity | 0.562 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260511 |
P23443 | Q13362 | 2 | binding | down-regulates | 0.341 | The human homolog of pp2a-b', ppp2r5c, also counteracts s6k1 phosphorylation, indicating a conserved mechanism in mammals | SIGNOR-165224 |
P42575 | Q96GD4 | 0 | phosphorylation | up-regulates activity | 0.244 | Furthermore, in vitro phosphorylation using GST-Casp2 363-423 WT or S384A confirmed that S384 of caspase-2 is phosphorylated by AURKB. | SIGNOR-279496 |
P16066 | P01160 | 2 | binding | up-regulates | 0.887 | Natriuretic peptide receptor-a (npra) is the biological receptor of the peptide hormones atrial natriuretic peptide (anp) and brain natriuretic peptide (bnp) | SIGNOR-137600 |
P17612 | Q15831 | 1 | phosphorylation | up-regulates activity | 0.502 | Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. | SIGNOR-250055 |
P43694 | Q4G0P3 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | HYDIN promotes expression of Gata4 in cardiomyocyte differentiation. HYDIN functions as a positive regulator of human cardiomyocyte differentiation and promotes expression of cardiac contractile genes in hESC cells. This is mediated through GATA4, a critical transcription factor in heart development. Cardiac-specific H... | SIGNOR-265479 |
P17252 | P46940 | 1 | phosphorylation | up-regulates | 0.258 | Using a mass spectrometry-based assay, we show that egf induces phosphorylation of iqgap1 ser(1443), a residue known to be phosphorylated by pkcthe nonphosphorylatable iqgap1 s1441a/s1443a had no effect. In contrast, the s1441e/s1443d mutation markedly enhanced the ability of iqgap1 to induce neurite outgrowth. | SIGNOR-128714 |
P09874 | Q9UGL1 | 1 | relocalization | up-regulates activity | 0.354 | The mechanism of KDM5B recruitment is quite specific and requires the presence of nucleosomes containing histone variant MacroH2A1.1 and PARylation by PARP1. | SIGNOR-271574 |
Q96B36 | P31751 | 0 | phosphorylation | down-regulates | 0.674 | Insulin-stimulated phosphorylation of pras40 by akt/pkb suppresses its mtorc1 inhibitory activity. | SIGNOR-153931 |
P48730 | O14641 | 1 | phosphorylation | up-regulates | 0.534 | Ck1_/__dependent phosphorylation of dvl2 at s143 and t224and that this event is critical to interact with plk1 in early stages of the cell cycle | SIGNOR-197547 |
Q9NR61 | P46531 | 2 | binding | up-regulates activity | 0.644 | Expression analysis of known notch ligands suggests that dll4 is the only ligand that exhibits spatial and temporal expression consistent with the activation of notch1 and notch4 during vascular development. The identification of dll4 reveals a candidate ligand for notch receptors involved in blood vessel biology | SIGNOR-112649 |
Q9UKM9 | Q99873 | 1 | post transcriptional regulation | up-regulates quantity | 0.247 | RALY binds poly-U rich elements within several RNAs and regulates the expression as well as the stability of specific transcripts. Here we show that RALY binds PRMT1 mRNA and regulates its expression.|We demonstrate that RALY down-regulation decreases protein arginine N-methyltransferase 1 levels | SIGNOR-262273 |
Q6NUQ1 | Q92878 | 2 | binding | up-regulates activity | 0.471 | We propose that p130, forming a complex with Rad50 through RINT-1, blocks telomerase-independent telomere lengthening in normal cells. | SIGNOR-265030 |
P11678 | P10153 | 1 | post translational modification | up-regulates activity | 0.476 | Human eosinophils are bone marrow-derived, non-dividing granulocytes of the innate immune system, which store the highly cationic proteins eosinophil peroxidase (EPO), major basic protein (MBP), eosinophil-derived neurotoxin (EDN), and eosinophil cationic protein (ECP) in secondary granules. we demonstrated that Tyr ni... | SIGNOR-261704 |
Q13315 | P53350 | 1 | phosphorylation | down-regulates activity | 0.429 | Indeed Chk2 mediates the degradation of Cdc25A to activate the S-phase checkpoint [5\u20137,18] , whereas ATM phosphorylates and inactivates Plk1, consolidating the delay in the entry into M phase [5\u201319] .|Indeed Chk2 mediates the degradation of Cdc25A to activate the S-phase checkpoint [5-7,18], whereas ATM pho... | SIGNOR-279793 |
P05067 | P53779 | 0 | phosphorylation | up-regulates | 0.582 | Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in sh-sy5y neuroblastoma cells. is regulated by jnk3 via phosphorylation of app at thr668 | SIGNOR-204671 |
Q13077 | P20333 | 2 | binding | up-regulates | 0.72 | Traf1 interacts with tnf-r2 indirectly through heterodimer formation with traf2. | SIGNOR-33133 |
O75602 | Q92949 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.447 | FOXJ1 expression in basal cells induced the expression of a panel of cilia-associated genes, including centrin 2 (CETN2); dynein, axonemal, heavy chain 11 (DNAH11); dynein, axonemal, intermediate chain 1 (DNAI1); dynein, axonemal, light intermediate chain 1 (DNALI1); EF-hand domain, C-terminal, containing 1 (EFHC1); sp... | SIGNOR-266935 |
O60486 | Q86YJ5 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | MARCH9, a member of the RING-CH family of transmembrane E3 ubiquitin ligases, down-regulates CD4, major histocompatibility complex-I (MHC), and ICAM-1 in lymphoid cells. To identify novel MARCH9 substrates, we used high throughput flow cytometry and quantitative mass spectrometry by stable isotope labeling by amino aci... | SIGNOR-271532 |
Q13887 | P49841 | 0 | phosphorylation | down-regulates | 0.368 | Stability of the klf5 is mediated by proteasomal degradation via phosphorylation by glycogen synthase kinase 3_ (gsk3_) and recognition by f-box and wd repeat domain-containing 7 (fbw7) of a phosphodegron sequence surrounding serine 303 in klf5 | SIGNOR-203627 |
Q969T9 | P12931 | 0 | phosphorylation | up-regulates activity | 0.297 | Using dominant-negative, constitutively active mutants, RNAi, and pharmacological studies, we demonstrated that phosphorylation of WBP2 at Tyr192 and Tyr231 could be regulated by c-Src and c-Yes kinases.We further showed that abrogating WBP2 phosphorylation impaired >60% of ERα reporter activity, putatively by blocking... | SIGNOR-273567 |
Q07889 | P19174 | 2 | binding | up-regulates | 0.647 | We provide evidence that sos1, a p21ras-specific guanine nucleotide exchange factor, directly binds to the sh3 domain of plc-gamma1, and that the sh3 domain of plc-gamma1 is involved in sos1-mediated p21ras activation. | SIGNOR-80024 |
P31749 | Q96QF0 | 1 | phosphorylation | up-regulates activity | 0.2 | Rabin8 is phosphorylated and activated by Akt in cells grown on stiff ECM. | SIGNOR-277802 |
Q70E73 | P50552 | 2 | binding | up-regulates activity | 0.578 | Here we show that Lpd is a substrate of Abl kinases and binds to the Abl SH2 domain. Phosphorylation of Lpd positively regulates the interaction between Lpd and Ena/VASP proteins. | SIGNOR-268426 |
Q8IU81 | P14316 | 2 | binding | up-regulates activity | 0.692 | We have identified two novel proteins that interact specifically with the C-terminal repression domain of Interferon Regulatory Factor-2 (IRF-2). These proteins, which we term IRF-2 binding proteins 1 and 2 (IRF-2BP1 and IRF-2BP2, the latter having two splicing isoforms, A and B), are nuclear proteins, and have the pro... | SIGNOR-224045 |
P23467 | Q9UM73 | 1 | dephosphorylation | down-regulates | 0.334 | Rptpbeta/zeta dephosphorylates alk at the site(s) in alk that is undergoing autophosphorylation through autoactivation. | SIGNOR-157175 |
Q9NS28 | P17612 | 0 | phosphorylation | up-regulates activity | 0.2 | Cyclic AMP- and cyclic GMP-dependent kinases (PKA, PKG) inhibit the interaction of RGS18 and 14-3-3 by phosphorylating S216. | SIGNOR-273786 |
Q13153 | Q13352 | 1 | phosphorylation | up-regulates | 0.2 | Serine 28 phosphorylation of nrif3 confers its co-activator function for estrogen receptor-alpha transactivation. p21-activated protein kinase 1 (pak1) phosphorylates eralpha at ser305 and this modification is important in eralpha transactivation function. | SIGNOR-178795 |
P63000 | Q9H0H5 | 0 | gtpase-activating protein | down-regulates activity | 0.586 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260512 |
P10586 | Q9NT99 | 2 | binding | up-regulates activity | 0.617 | The NGL (netrin-G ligand; LRRC4) family of synaptic cell adhesion molecules belongs to the superfamily of leucine-rich repeat (LRR) proteins. The three known members of the NGL family, NGL-1, NGL-2, and NGL-3, are mainly localized to the postsynaptic side of excitatory synapses, and interact with the presynaptic ligand... | SIGNOR-264049 |
Q06124 | P21802 | 1 | dephosphorylation | down-regulates activity | 0.622 | In forming this heterotetrameric complex Grb2 inhibits both the dephosphorylation of FGFR2 by Shp2 and the phosphorylation of Shp2 by FGFR2 (XREF_FIG, respectively).|Knockdown of Grb2 elevates Shp2 phosphorylation (XREF_FIG), strongly suggesting that the inability of Shp2 to interact directly with the receptor in the p... | SIGNOR-277030 |
P45983 | Q13469 | 1 | phosphorylation | down-regulates | 0.752 | Jnks directly phosphorylate nuclear factor of activated t-cell (nfat) transcription factors, thus antagonizing the effects of calcium-regulated signaling through the protein phosphatase calcineurin jnk directly regulated nuclear factor of activated t-cell (nfat) activation in culture and in transgenic mice containing ... | SIGNOR-118217 |
P04035 | Q86TM6 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.562 | In the presence of the ubiquitin-conjugating enzyme UBC7, the RING-H2 finger has in vitro ubiquitination activity for Lys(48)-specific polyubiquitin linkage, suggesting that human HRD1 is an E3 ubiquitin ligase involved in protein degradation.Human HRD1 appears to be involved in the basal degradation of 3-hydroxy-3-met... | SIGNOR-272594 |
O00566 | Q96G21 | 2 | binding | up-regulates activity | 0.818 | Mpp10 represents a platform for the interaction of multiple factors within the 90S pre-ribosome. In eukaryotes, ribosome assembly is a highly complex process that involves more than 200 assembly factors that ensure the folding, modification and processing of the different rRNA species as well as the timely association ... | SIGNOR-261174 |
P09651 | P01106 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.456 | We also demonstrate that the oncogenic transcription factor c-Myc upregulates transcription of PTB, hnRNPA1 and hnRNPA2, | SIGNOR-268690 |
Q16539 | Q14790 | 1 | phosphorylation | down-regulates | 0.55 | P38-mapk can directly phosphorylate and inhibit the activities of caspase-8 | SIGNOR-122103 |
Q07869 | Q7Z6Z7 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Furthermore, the E3 ubiquitin ligase HUWE1 was identified to mediate PPARalpha polyubiquitination.|This notion is also supported by our finding that Huwe1 knockdown up-regulated the expression of PPARalpha target genes at the cellular level. | SIGNOR-278814 |
Q86XI6 | P13807 | 2 | binding | up-regulates | 0.714 | In the liver, PTG and PPP1R3B(GL)are expressed at roughly equivalent levels [55], and they jointly promote hepatic glycogen mobilization and storage. PTG overexpression significantly increased glycogen content, mainly due to its ability to promote the redistribution of PP1 and glycogen synthase to glycogen granules, si... | SIGNOR-271734 |
Q7Z6Z7 | P04198 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.423 | HUWE1 ubiquitinates and directs MYCN degradation to the proteasome. | SIGNOR-278750 |
P49810 | P55212 | 0 | cleavage | up-regulates activity | 0.363 | In decreasing order of activity, caspase-8, -3, -1, -6 and -7 proteolysed PS2 at the recognition site D326SYD329. | SIGNOR-261750 |
Q13761 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.579 | RUNX3 protein is ubiquitinated by MDM2 at Lys-94 and Lys-148.|RUNX3 protein is ubiquitinated by MDM2 at Lys 94 and Lys 148.|MDM2 suppresses the transcriptional activity of RUNX3. | SIGNOR-278557 |
Q53HL2 | P33981 | 0 | phosphorylation | up-regulates | 0.461 | First, we confirmed that wild-type borealin is phosphorylated at the previously described sites t88, t94, t169, and t230 when present in complex with survivin borealin might be a substrate for mps1. In the case of wild-type borealin, the fast exchange between the monomeric and dimeric forms may allow mps1 to phosphoryl... | SIGNOR-186151 |
P24941 | P30291 | 2 | null | down-regulates quantity by destabilization | 0.666 | PS123 primes CK2 to phosphorylate S121, resulting in creation of a β-TrCP phosphodegron (EEGFGpS121) that is responsible for the instability of Wee1A during interphase. | SIGNOR-276039 |
Q9UP95 | Q9BYP7 | 0 | phosphorylation | down-regulates activity | 0.464 | We have shown that with-no-lysine kinase 3 (WNK3) possesses several properties that suggest it could be the Cl−/volume-sensitive regulatory kinase that, in association with protein phosphatases, reciprocally modifies the phosphorylation/dephosphorylation states of the SLC12 proteins and thus their activities|WNK3 activ... | SIGNOR-264627 |
P40763 | P16591 | 0 | phosphorylation | up-regulates activity | 0.402 | Replacing the unique 43-amino acid-long N-terminal tail of p51 (ferT) with a parallel segment from the N-terminal tail of p94 (fer) did not change the subcellular localization of p51 (ferT) but enabled it to activate Stat3.|When combined with immunoprecipitation analysis, this assay showed that p94 (fer) can lead to th... | SIGNOR-279713 |
P49023 | P12931 | 0 | phosphorylation | up-regulates activity | 0.808 | Here, we demonstrate that Src kinase directly phosphorylates Y88 paxillin|In this study, we also show how pY88 paxillin transduces a signal to activate Akt | SIGNOR-263977 |
P05305 | P24530 | 2 | binding | up-regulates | 0.946 | Endothelin-1 (et-1) and angiotensin ii (angii), two potent vasoactive peptides involved in the regulation of cardiovascular homeostasis, also induce mitogenic and pro-angiogenic responses in vitro and in vivo. Both peptides are produced by cleavage of inactive precursors by metalloproteases (endothelin-converting enzym... | SIGNOR-145762 |
P11831 | Q9UQM7 | 0 | phosphorylation | up-regulates activity | 0.369 | Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites. | Microsequencing of these phosphorylated peptides identified that both Ser-103 and a novel residue, Thr-160 in the MADS box of SRF, were sites of phosphorylation. | The location of Thr-160 in the 3-D structure of SRF s... | SIGNOR-250639 |
Q00978 | P48551 | 2 | binding | up-regulates activity | 0.727 | By binding to IFNalphaR2 within the region where two adjacent proline boxes bear phospho-Ser364 and phospho-Ser384, CBP acetylates IFNalphaR2 on Lys399, which in turn serves as the docking site for interferon regulatory factor 9 (IRF9)RF9 interacts with the acetyl-Lys399 motif by means of its IRF homology2 (IH2) domain... | SIGNOR-217779 |
Q7L591 | P07948 | 0 | phosphorylation | up-regulates activity | 0.409 | An adaptor protein Dok-3 mediates the suppressive function of LYN. The Dok-3 phosphorylated by LYN upon BCR stimulation forms a complex with GRB2, which allows it to enter into the signalosome and associate with activation of SHIP protein. This translocation facilitates the efficient inhibition of PLCc2 and SYK from ac... | SIGNOR-268447 |
P09429 | P31249 | 2 | binding | up-regulates activity | 0.298 | We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-... | SIGNOR-219980 |
Q8TD08 | P05412 | 1 | phosphorylation | up-regulates | 0.428 | Up-regulation of c-jun mrna in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-jun n-terminal kinases are required for efficient up-regulation of c-jun protein. these data suggest that erks, rather than jnks, are required for c- jun up-regulation. | SIGNOR-91375 |
Q13490 | O43353 | 1 | polyubiquitination | up-regulates activity | 0.652 | CIAP1/2 are direct E3 ligases conjugating diverse types of ubiquitin chains to receptor interacting proteins kinases 1 to 4 (RIP1-4).Together, our results demonstrate that depleting cIAP1/2 inhibits RIP1-4 mediated NF-kB activation without affecting RIP auto-phosphorylation. | SIGNOR-272712 |
P53350 | P78527 | 2 | phosphorylation | up-regulates activity | 0.425 | Moreover, PLK1 phosphorylates DNA-PKcs directly on Ser 3205 invitro, suggesting that DNA-PKcs Ser 3205 is a direct target of PLK1 in mitosis. | SIGNOR-278188 |
P67775 | P05771 | 1 | dephosphorylation | down-regulates activity | 0.446 | Specifically, the threonine at position 500 (T500) on the activation loop, and T641 and S660 on the carboxyl terminus of protein kinase C beta II are phosphorylated in vivo. T500 and S660 are selectively dephosphorylated in vitro by protein phosphatase 2A to yield an enzyme that is still capable of lipid-dependent acti... | SIGNOR-248620 |
O60315 | P0C2W1 | 2 | binding | down-regulates quantity by destabilization | 0.362 | One of the hallmarks of EMT is loss of E-cadherin and gain of N-cadherin expression, which are regulated by the core EMT-inducing transcription factors (EMT-TFs), such as Zeb1/2, Snai1/2 and Twist1. Here, we find that EMT-TFs can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbx... | SIGNOR-272180 |
Q16236 | Q13131 | 0 | phosphorylation | up-regulates activity | 0.2 | MS-based analysis of immunoprecipitated Nrf2 revealed serine 374, 408 and 433 in human Nrf2 to be hyperphosphorylated as a function of activated AMPK. A direct phosphate-transfer by AMPK to those sites was indicated by in vitro kinase assays with recombinant proteins as well as interaction of AMPK and Nrf2 in cells, ev... | SIGNOR-277496 |
P06493 | Q15116 | 1 | phosphorylation | down-regulates quantity by destabilization | 0.2 | We demonstrated that cyclin-dependent kinase 1-mediated phosphorylation of Ser261 residue primes PD-1 protein nucleus translocation and binding with FBW7. | SIGNOR-277605 |
O43464 | P98170 | 2 | binding | down-regulates | 0.709 | Here we report that a serine protease called htra2/omi is released from mitochondria and inhibits the function of xiap by direct binding in a similar way to diablo. | SIGNOR-110834 |
O15264 | P10636 | 1 | phosphorylation | down-regulates activity | 0.531 | Phosphorylation of tau by SAPK3 and SAPK4 resulted in a marked reduction in the ability of tau to promote microtubule assembly. | SIGNOR-278313 |
Q7Z5J4 | O15516 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.479 | RAI1 Transcriptionally Activates CLOCK via an Intron 1 Enhancer Element. data suggest that RAI1 binds, directly or in a complex, to the first intron of CLOCK and enhances its transcriptional activity in vitro, supporting RAI1 as a positive regulator of CLOCK and an important part of the circadian loop of transcription.... | SIGNOR-266839 |
Q9NP80 | Q9BUB5 | 0 | phosphorylation | up-regulates activity | 0.2 | Constitutively active MNK1 activates and phosphorylates iPLA2γ. Thus, complement-mediated activation of iPLA(2)γ is mediated via ERK and p38 pathways, and phosphorylation of Ser-511 and/or Ser-515 plays a key role in the catalytic activity and signaling of iPLA(2)γ. | SIGNOR-273677 |
P24071 | P67775 | 0 | dephosphorylation | up-regulates activity | 0.323 | Furthermore, FcalphaRI activation is induced by protein phosphatase 2A (PP2A) after it dephosphorylates a single serine residue (S263) in the FcalphaRI intracellular tail | SIGNOR-264858 |
Q99558 | O15111 | 2 | phosphorylation | up-regulates activity | 0.698 | Once activated by autophosphorylation, nik activates ikkalpha, which in turn phosphorylates nf-kb2. This stimulates limited proteasome-mediated proteolysis of nf-kb2 to p52. Removal of the carboxy-terminal ankyrin repeats from nf-kb2 releases the p52/RELB heterodimer, allowing its translocation to the nucleus where it ... | SIGNOR-167060 |
O14503 | P48729 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.2 | CK1α-mediated phosphorylation of DEC1 on a conserved degron is required for DEC1 degradation. | SIGNOR-276851 |
Q9BT81 | Q9HCK8 | 0 | transcriptional regulation | down-regulates quantity | 0.2 | Many of the most significantly up-regulated genes in Chd8+/− and Chd8−/− NPCs are involved in later stages of neuronal development, including Ascl1 [a central driver of neural reprogramming (29)], Dcx, Map2, Nefm, Neurod4, and Neurog1 (Fig. 2 E and F). Additionally, we found that Sox3 is derepressed in both Chd8+/− and... | SIGNOR-268922 |
Q9HCE7 | Q96AC1 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Smurf1 mediates Kindlin-2 proteasomal degradation.|Smurf1 promotes polyubiquitination of Kindlin-2. | SIGNOR-278614 |
P49327 | O15379 | 0 | deacetylation | up-regulates quantity by stabilization | 0.2 | Overexpression of HA-HDAC3 decreased the acetylation level of endogenous FASN by 35% in HEK293T cells, while the expression of a catalytic inactive mutant HDAC3Y298H (38) failed to reduce FASN acetylation (Fig. 4C). Conversely, HDAC3 knockdown increased the acetylation level of endogenous FASN by >1.5-fold in HEK293T c... | SIGNOR-267367 |
Q04760 | P07947 | 0 | phosphorylation | up-regulates activity | 0.2 | We show that Glo1 activity is promoted by phosphorylation on Tyrosine 136 via multiple kinases. Glo1 Y136 is phosphorylated by multiple different kinases including all members of the Src family. Depletion of multiple different kinases led to a partial reduction in Glo1(Y136) phosphorylation. These included members of t... | SIGNOR-276185 |
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