IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
Q16566 | Q9UNW9 | 1 | phosphorylation | up-regulates quantity | 0.255 | CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. CaMKIV Phosphorylates Nova-2 and Regulates Its Nuclear Localization. Conversely, Nova-2 with single or double mutations to alanine (2A and 1A2A) was predominantly nuclear, like the WT (Figures 5H and and5I).5I). In contrast, glutamate mutations at s... | SIGNOR-273521 |
P29966 | P17252 | 0 | phosphorylation | down-regulates activity | 0.73 | Here we report that MARCKS is a filamentous (F) actin crosslinking protein, with activity that is inhibited by PKC-mediated phosphorylation and by binding to calcium-calmodulin | SIGNOR-249650 |
P24941 | P38936 | 2 | phosphorylation | down-regulates quantity by destabilization | 0.954 | Cdk2 destabilizes p21 via the cy2 cyclin-binding motif and p21 phosphorylation at ser-130. | SIGNOR-149416 |
P03372 | P27986 | 2 | binding | up-regulates | 0.628 | Recently, it has been known that er activates phosphatidylinositol-3-oh kinase (pi3k) through binding with the p85 regulatory subunit of pi3k. | SIGNOR-140470 |
P06241 | Q9Y210 | 1 | phosphorylation | up-regulates activity | 0.505 | Fyn phosphorylates TRPC6 and increases its diacylglycerol stimulated single channel activity. | SIGNOR-279717 |
P15374 | P62979 | 1 | cleavage | up-regulates quantity | 0.802 | Here we provide data suggesting that two of the four mammalian ubiquitin precursors, UBA52 and UBA80, are processed mostly post-translationally whereas the other two, UBB and UBC, probably undergo a combination of co- and post-translational processing. Using an unbiased biochemical approach we found that UCHL3, USP9X, ... | SIGNOR-270828 |
P61073 | Q05655 | 0 | phosphorylation | down-regulates activity | 0.2 | Therefore, internalization of CXCR4 in response to PMA appears to be mediated by activation of protein kinase C | However, mutation of the dileucine motif or the serines at positions 324, 325, 338, and 339 profoundly decreased internalization. | SIGNOR-260898 |
P09471 | P25103 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257249 |
Q14449 | P49840 | 0 | phosphorylation | down-regulates activity | 0.264 | Phosphorylation of clustered serine residues in the N-terminus of BPS domain negatively regulates formation of the complex between human Grb14 and insulin receptor| In vitro kinase assay using the motif-derived peptides showed that the serine residues located in N-terminal (Ser358, Ser362 and Ser366) and C-terminal (Se... | SIGNOR-264871 |
P12931 | Q13642 | 1 | phosphorylation | up-regulates activity | 0.26 | However, overexpression of Src promoted most of the Flag-FHL1-WT to translocate to the nucleus, whereas the Flag-FHL1-Y149-272F mutant (phosphorylation deficient mutant) remained in the cytoplasm (XREF_FIG).|We found that Src phosphorylates FHL1 at Y149 and Y272, demonstrating that FHL1 is a bona fide novel substrate o... | SIGNOR-278213 |
Q96GD4 | Q99661 | 1 | phosphorylation | up-regulates | 0.731 | Here, we show that the binding of mcak to chromosome arms is also regulated by aurora b and that aurora b-dependent chromosome arm and centromere localization is regulated by distinct two-site phosphoregulatory mechanisms. Mcak association with chromosome arms is promoted by phosphorylation of t95 on mcak, whereas phos... | SIGNOR-155890 |
P78527 | O75030 | 1 | phosphorylation | up-regulates activity | 0.2 | These results suggest that DNA-PK can target MITF-S325 for phosphorylation. In melanocytes and melanoma cells, MITF is rapidly phosphorylated by DNA-PK and interacts with NBS1–RAD50 but not MRE11, destabilizing the MRN complex. | SIGNOR-277899 |
Q9ULT8 | P07900 | 1 | ubiquitination | down-regulates quantity | 0.2 | We demonstrate that Hectd1 is a functional ubiquitin ligase and that one of its substrates is Hsp90, a chaperone protein with both intra- and extracellular clients. Identification of Hsp90 in both proteomic screens suggested that members of the Hsp90 superfamily may be substrates of Hectd1. Myc-Hectd1ANK and HA-Hsp90b... | SIGNOR-261199 |
Q92830 | P84243 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269603 |
Q9NPD5 | P53567 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Taken together, these findings suggest that the LPS-induced down-regulation of Oatp4 is likely due to reduction in the binding of HNF1alpha, C/EBP, HNF3, and RXR:RAR to the Oatp4 promoter. | SIGNOR-268986 |
O15530 | Q00005 | 2 | binding | down-regulates activity | 0.331 | Here, we show that PPP2R2B, encoding the B55² regulatory subunit of the PP2A complex, is epigenetically inactivated by DNA hypermethylation in colorectal cancer. B55²-associated PP2A interacts with PDK1 and modulates its activity toward Myc phosphorylation. | SIGNOR-243511 |
P43405 | P15498 | 2 | phosphorylation | up-regulates | 0.92 | Vav interacts with the tyrosine kinase syk. inhibition of syk kinase activity prevents tyrosine phosphorylation of vav and its interaction with pi 3-k. | SIGNOR-107046 |
P01019-PRO_0000032457 | P12821 | 2 | binding | up-regulates activity | 0.2 | Ang I is subsequently converted into the major RAS effector peptide Ang II or Ang (1–8), through activity of the zinc-dependent protease ACE, which hydrolyzes two amino acids from the carboxy terminus of Ang I | SIGNOR-260231 |
Q00535 | Q13794 | 1 | phosphorylation | down-regulates | 0.356 | We show that noxa is phosphorylated on a serine residue (s(13)) in the presence of glucose. Phosphorylation promotes its cytosolic sequestration and suppresses its apoptotic function. We identify cdk5 as the noxa kinase | SIGNOR-170357 |
Q05397 | P63000 | 1 | phosphorylation | up-regulates activity | 0.574 | Both Src and FAK phosphorylate Rac1 at tyrosine 64.|Our investigations of direct interactions between Rac1, Src, and FAK were motivated by our previous insights into FAK augmentation of Rac1 activation during cell spreading, and the Cerione lab 's work on the interactions between Src and Cdc42 , . | SIGNOR-279652 |
Q99523 | Q13153 | 0 | phosphorylation | down-regulates activity | 0.2 | PAKs specifically phosphorylate Ser15 of the sortilin-cd and alter its trafficking. It can be concluded that PAK1-3 may indeed instigate the phosphorylation of sortilin and that they target a single serine residue (Ser15) located in the kinase domain-binding site of the sortilin-cd. Full-length sortilins with the serin... | SIGNOR-273718 |
Q92914 | Q9UI33 | 2 | binding | down-regulates activity | 0.2 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253438 |
Q6STE5 | P15172 | 2 | binding | up-regulates activity | 0.538 | We show that the muscle determination factor MyoD and the SWI/SNF subunit BAF60c interact on the regulatory elements of MyoD-target genes in myoblasts, prior to activation of transcription. BAF60c facilitates MyoD binding to target genes and marks the chromatin for signal-dependent recruitment of the SWI/SNF core to mu... | SIGNOR-238289 |
Q13586 | P28482 | 0 | phosphorylation | up-regulates | 0.351 | The netrin-2-mediated nfatc3 activation was coincident with robust interactions between cdo and stim1 in myoblasts and the erk-mediated stim1 phosphorylation at serine 575 | SIGNOR-192788 |
P78527 | P31749 | 1 | phosphorylation | up-regulates activity | 0.754 | DNA-PK phosphorylates HM Ser473 of PKB. However, we also noted similar patterns in T loop Thr308 phosphorylation after _-IR []his function is apparently restricted to the PKBalpha isoform | SIGNOR-252431 |
P06493 | P53350 | 2 | binding | up-regulates activity | 0.611 | Moreover, CDK1 phosphorylates RSF1 at Ser1375, and this phosphorylation is necessary for PLK1 recruitment. Subsequently, PLK1 phosphorylates RSF1 at Ser1359, stabilizing PLK1 deposition. | SIGNOR-273589 |
Q04637 | P17252 | 0 | phosphorylation | up-regulates activity | 0.258 | Phospho-proteomic and mutational analyses revealed that eIF4G1 is a substrate for PKCα at Ser1186. | SIGNOR-276327 |
O14640 | Q53G59 | 2 | binding | down-regulates quantity by destabilization | 0.621 | KLHL12 recruits Dsh to Cullin-3 for protein degradation. In vitro ubiquitination of Dsh3 by KLHL12–Cullin-3–Roc1. The E3 ligase complex was obtained by transfection of HEK293T cells . We show that the BTB-containing protein KLHL12 negatively regulates Dsh function by recruiting a pool of Dsh to the Cullin-3 ligase sc... | SIGNOR-271558 |
Q05655 | P04040 | 1 | phosphorylation | up-regulates activity | 0.266 | Endothelin-1 stimulates catalase activity through the PKCδ-mediated phosphorylation of serine 167. | SIGNOR-260904 |
Q9H0K1 | O75581 | 1 | phosphorylation | up-regulates activity | 0.2 | Mechanistically, SIK2, phosphorylated by CK1α, directly phosphorylated LRP6 in a SIK2 kinase activity-dependent manner, leading to Wnt/β-catenin signaling pathway activation. | SIGNOR-275399 |
Q9H2X6 | P06276 | 1 | phosphorylation | down-regulates quantity | 0.2 | As shown in XREF_FIG, HIPK2 overexpression strongly reduced Myc-Che-1 levels, whereas it produced little effect on Che-1 T144A expression.|Notably, we found that HIPK2 phosphorylates a specific residue of Che-1, which is required for its interaction with Pin1 and for its degradation through the proteasome pathway. | SIGNOR-279190 |
P08246 | P05546 | 1 | cleavage | down-regulates activity | 0.451 | Amino acid sequence analysis led to the conclusion that both neutrophil elastase and cathepsin G cleave HC at Ile66, which does not affect HC activity, and at Val439, near the reactive site Leu444, which inactivates HC. | SIGNOR-256510 |
Q96SW2 | Q9H3D4 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | CRBN functions as a substrate receptor of the E3 ubiquitin ligase CRL4, whose substrate specificity is modulated by thalidomide and its analogs.When thalidomide binds to CRBN, substrate specificity of CRL4CRBN is altered and CRBN neomorphically binds to ∆Np63, TAp63 and other neosubstrates and ubiquitinates them for pr... | SIGNOR-272214 |
Q8NHW3 | P49841 | 0 | phosphorylation | down-regulates quantity by destabilization | 0.257 | We also demonstrate that gsk-3 triggers mafa sequential phosphorylation on residues s61, t57, t53, and s49 /we demonstrated that phosphorylation by gsk-3 is conserved among the large maf proteins. It couples ubiquitination/degradation and transcriptional activation and modulates maf biological activity./ Taken together... | SIGNOR-159462 |
Q05195 | P17480 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.36 | MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation|MAD1 repressed and c-MYC activated rDNA transcription in nuclear run-on assays. Repression of rDNA transcription by MAD1 was associated with its ability to interact directly with the promoter of upstream binding factor (UBF), an rDNA ... | SIGNOR-269646 |
Q9NP62 | Q14012 | 0 | phosphorylation | up-regulates activity | 0.388 | We show that Epac1 and Rap1, in response to cAMP, activate CaMKI to phosphorylate Ser47 in GCM1. This phosphorylation facilitates the interaction between GCM1 and the desumoylating enzyme SENP1 and thereby leads to GCM1 desumoylation and activation. | SIGNOR-262680 |
P28336 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257315 |
Q71DI3 | Q9Y4C1 | 0 | demethylation | up-regulates activity | 0.2 | Using a biochemical assay coupled with chromatography, we have purified a JmjC domain-containing protein, JHDM2A, which specifically demethylates mono- and dimethyl-H3K9. | SIGNOR-276844 |
O14654 | Q9UNE7 | 0 | polyubiquitination | down-regulates quantity by destabilization | 0.2 | IRS4 was phosphorylated at Ser859 by CK1γ2 in vitro and in vivo, which promoted the polyubiquitination and degradation of IRS4 through the ubiquitin/lysosome pathway by the carboxyl terminus of Hsc70-interacting protein(CHIP). | SIGNOR-277616 |
P12931 | P78352 | 1 | phosphorylation | up-regulates | 0.565 | These results indicate that psd-95 phosphorylation by src facilitates the integration of pyk2 to psd-95 signal complex, the activation of pyk2/src, as well as the subsequent tyrosine phosphorylation of nr2a, which ultimately results in the upregulation of nmda receptor function and synaptic transmission. | SIGNOR-205120 |
Q15276 | Q15139 | 0 | phosphorylation | up-regulates activity | 0.382 | PKD phosphorylates Rabaptin-5 at Ser407, and this controls alphavbeta3 and alpha5beta1 integrin and EGFR recycling. | SIGNOR-278192 |
Q5VWQ8 | P15976 | 2 | binding | up-regulates activity | 0.2 | DAB2IP suppresses transcription of stem cell factor receptor CD117, by interacting with GATA-1 on a silencer element on its gene | SIGNOR-254770 |
P50542 | O43933 | 2 | binding | up-regulates activity | 0.548 | Pex1, Pex6, and Pex26 are involved in Pex5 export from peroxisomes., we found that Pex1 and Pex6 bind to Pex5 (Fig. (Fig.6). Therefore, it is conceivable that Pex1 and Pex6 pull out Pex5 from peroxisome membranes in an ATP-dependent manner. | SIGNOR-253618 |
Q13315 | Q9Y6K9 | 1 | phosphorylation | down-regulates activity | 0.739 | Atm phosphorylates serine-85 of nemo to promote its ubiquitin-dependent nuclear export. | SIGNOR-144813 |
Q8N752 | Q8NEG4 | 2 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273759 |
Q13185 | P17612 | 0 | phosphorylation | up-regulates | 0.2 | We demonstrate that p-ser 83-hp1gamma has an exclusively euchromatic localization, interacts with ku70 (a regulatory protein involved in multiple nuclear procesess), has impaired silencing activity and serves as a marker for transcription elongation. | SIGNOR-145109 |
Q09472 | P31749 | 0 | phosphorylation | up-regulates | 0.697 | We find that suberoylanilide hydroxamic acid stimulates akt activity, which is required to phosphorylate p300 at ser(1834). Akt-mediated phosphorylation of p300 dramatically increases its acetyltransferase activity | SIGNOR-148983 |
Q9NR28 | P53779 | 0 | phosphorylation | down-regulates | 0.341 | Here we demonstrate that jnk3 can phosphorylate smac. Phosphorylation of smac by jnk3 attenuates its interaction with xiap. These results suggest that jnk3 activity can attenuate the progression of apoptosis through a novel mechanism of action, the down-regulation of interaction between smac and xiap. | SIGNOR-157280 |
P51812 | O15297 | 0 | dephosphorylation | down-regulates activity | 0.361 | RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the pres... | SIGNOR-248322 |
P01189 | P40763 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.638 | We show that phospho-STAT3 activates POMC promoter in response to leptin signaling through a mechanism that requires an SP1-binding site in the POMC promoter. | SIGNOR-263497 |
Q7Z6Z7 | P43405 | 0 | phosphorylation | up-regulates activity | 0.2 | Collectively, these data suggest that TNF induced tyrosine phosphorylation of Mule by Syk contributes to its E3 ligase activity. | SIGNOR-280150 |
Q14814 | P23409 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.573 | Myogenin and MEF2 function synergistically to activate the MRF4 promoter during myogenesis. | SIGNOR-238715 |
P23771 | Q969H0 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.403 | Fbw7 promotes degradation of GATA3 in a Thr-156-dependent manner. | SIGNOR-276635 |
P49840 | Q13554 | 0 | phosphorylation | down-regulates | 0.291 | Inhibitory phosphorylation of gsk-3 by camkii couples depolarization to neuronal survival. | SIGNOR-167962 |
P04179 | Q16236 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.45 | BTG2 was found to up-regulate expression of antioxidant enzymes known to be regulated by NFE2L2, including catalase, SOD1, and SOD2 | SIGNOR-254652 |
P42224 | O14543 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.677 | Expression of SOCS1 and SOCS3 is regulated primarily by activation of STAT1 and STAT3, respectively, although their expression can be mediated through other signaling cascades, including the mitogen activated protein kinase (MAPK) and nuclear factor-kappa B (NF-kappaB) pathways. | SIGNOR-249565 |
Q16633 | P14859 | 2 | binding | up-regulates | 0.622 | Obf1 enhances transcriptional potential of oct1. | SIGNOR-100968 |
O75582 | Q92934 | 1 | phosphorylation | down-regulates activity | 0.344 | Phosphorylation of Bad at Ser112 in response to growth factors or cytokines is generally linked to cell survival. Knockdown of MSK1 suppressed Bad phosphorylation after calcium ionophore A23187 treatment in neuronal cells | SIGNOR-262990 |
P11142 | O75061 | 0 | relocalization | up-regulates activity | 0.883 | Hsc70, recruited by the J-domain protein auxilin, mediates clathrin uncoating and release of a free vesicle, primed to fuse with a target membrane. | SIGNOR-260719 |
P29353 | P29317 | 2 | binding | up-regulates | 0.616 | We also show that the interaction of epha2 with grb2 is indirect and mediated by shc and that this complex is necessary for epha2-mediated activation of erk kinases. | SIGNOR-94804 |
P28482 | Q96RK0 | 1 | phosphorylation | down-regulates | 0.372 | Specifically, 14-3-3 binds to p90(rsk)-phosphorylated ser?_??_ Of capic?_A thereby modulating dna binding to its hmg (high-mobility group) box, whereas erk phosphorylations prevent binding of a c-terminal nls (nuclear localization sequence) to importin ?4 (kpna3))[...] These results suggest that erk phosphorylation of ... | SIGNOR-169875 |
P08575 | P23458 | 1 | dephosphorylation | up-regulates | 0.454 | These negative regulatory effects on ig class switching were concomitant with the ability of cd45 to dephosphorylate the induced phosphorylation of jak1, jak3, | SIGNOR-87154 |
P13674 | Q01581 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | In this study, we found that the prolyl 4-hydroxylase (P4H) subunit P4HA1 protects NPC cells from erastin-induced ferroptosis by activating HMGCS1, a key enzyme in the mevalonate pathway. Our results show that HMGCS1 and HMGCR are regulated by P4HA subunits at the transcriptional level (Fig. S4). | SIGNOR-279853 |
Q8N122 | P27361 | 0 | phosphorylation | up-regulates activity | 0.469 | We found three proline-directed residues within raptor, ser(8), ser(696), and ser(863), which are directly phosphorylated by erk1/2. Expression of phosphorylation-deficient alleles of raptor revealed that phosphorylation of these sites by erk1/2 normally promotes mtorc1 activity and signaling to downstream substrates, ... | SIGNOR-169530 |
P17252 | Q16760 | 1 | phosphorylation | down-regulates activity | 0.366 | The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain. | SIGNOR-249265 |
P25101 | P19086 | 2 | binding | up-regulates activity | 0.25 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257320 |
Q13905 | P46108 | 2 | binding | up-regulates | 0.901 | The endogenous c3g could be coprecipitated with crk from cell lysates of cells expressing high levels of c-crk or v-crk, suggesting high binding affinity and a possible interaction in vivo. | SIGNOR-33732 |
Q13547 | Q96KB5 | 0 | phosphorylation | up-regulates activity | 0.245 | TOPK overexpression promotes HDAC1 and HDAC2 phosphorylation and Histone 3 and Histone 4 acetylation in BV2 cells.|The results of in vitro studies further confirmed the effect of TOPK on HDAC activity by showing that TOPK overexpression significantly up-regulated p-HDAC1 and p-HDAC2, resulting in an increase in the ace... | SIGNOR-279086 |
P63000 | Q9BRR9 | 0 | gtpase-activating protein | down-regulates activity | 0.606 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260464 |
O15357 | Q9ULV8 | 2 | binding | down-regulates | 0.2 | This association between ship2 and cbl could sequester cbl from the egfr, thereby regulating the kinetics of egfr-cbl association and subsequent internalization and degradation of the receptor. | SIGNOR-133388 |
P00519 | P37231 | 1 | phosphorylation | up-regulates quantity | 0.341 | We show that the tyrosine kinase Abelson murine leukemia viral oncogene (cAbl) is an adipogenic key regulator. c-Abl promotes adipogenesis by phosphorylation and subsequent stabilization of PPARγ. | SIGNOR-262297 |
Q92835 | P16885 | 1 | dephosphorylation | down-regulates activity | 0.312 | An adaptor protein Dok-3 mediates the suppressive function of LYN. The Dok-3 phosphorylated by LYN upon BCR stimulation forms a complex with GRB2, which allows it to enter into the signalosome and associate with activation of SHIP protein. This translocation facilitates the efficient inhibition of PLCc2 and SYK from ac... | SIGNOR-268455 |
P53350 | Q96FF9 | 1 | phosphorylation | down-regulates activity | 0.705 | Here we show that the mitotic kinases Aurora B and Cyclin-dependent kinase 1 (Cdk1) destabilize interactions between Sororin and the cohesin subunit precocious dissociation of sisters protein 5 (Pds5) by phosphorylating Sororin, leading to release of acetylated cohesin from chromosome arms and loss of cohesion. | SIGNOR-276122 |
O14920 | Q9NQC7 | 1 | phosphorylation | down-regulates activity | 0.548 | Thus, serine 418 is phosphorylated in vivo.Cyld phosphorylation may serve as a mechanism to inactivate its traf2 deubiquitination activity. | SIGNOR-204716 |
Q00535 | P00352 | 1 | phosphorylation | up-regulates quantity | 0.2 | Cdk5 Phosphorylates ALDH1A1 at S75 and S274.|These results demonstrate that Cdk5 increases ALDH1A1 levels in neurotoxin exposed neuronal cells both at transcriptional level and by direct phosphorylation at S75 and S274 sites. | SIGNOR-279399 |
Q96LA8 | Q9NRC8 | 1 | methylation | down-regulates activity | 0.259 | Protein arginine methyltransferase 6 (PRMT6) directly interacts with and methylates SIRT7 at R388 in vitro and in vivo R388 methylation suppresses the H3K18 deacetylase activity of SIRT7 without modulating its subcellular localization. | SIGNOR-275888 |
P46060 | O75592 | 1 | relocalization | down-regulates quantity by destabilization | 0.315 | SUMOylated RanGAP1 Inhibits MYCBP2 Activity and Mediates Its Transport to the Nucleus. Surprisingly, we did not find MYCBP2-dependent ubiquitylation of SUMOylated RanGAP1 but instead a strong inhibition of the ubiquitin ligase activity of MYCBP2 in the presence of SUMOylated RanGAP1, as determined by the presence of ub... | SIGNOR-261203 |
P30305 | Q9UNH5 | 0 | dephosphorylation | down-regulates activity | 0.56 | Cdc14A inhibits Cdc25A and Cdc25B activity, the latter through direct binding and dephosphorylation ( ).|Together, these data indicate that Cdc14A dephosphorylates Cdc25B, inhibiting its catalytic activity. | SIGNOR-276968 |
Q9Y5Q3 | P49840 | 0 | phosphorylation | down-regulates | 0.2 | We showed that c-maf and mafb, like mafa, are indeed phosphorylated by gsk-3/ we demonstrated that phosphorylation by gsk-3 is conserved among the large maf proteins. It couples ubiquitination/degradation and transcriptional activation and modulates maf biological activity. | SIGNOR-159432 |
P41221 | Q13467 | 2 | binding | up-regulates | 0.832 | These results identify hfz5 as a receptor for wnt-5a. | SIGNOR-46897 |
Q7Z6J0 | Q12852 | 2 | binding | up-regulates | 0.376 | One explanation as provided by our model is that mlk3 and dlk interact indirectly via posh with mutual activation when both are wild-type the multidomain protein posh binds to the constitutively active form of rac1, which is known to regulate the activity of mlks, while jip1 binds to mlks and additional components of ... | SIGNOR-108577 |
P06493 | Q08050 | 1 | phosphorylation | up-regulates | 0.762 | A conserved phosphorylation site within the forkhead domain of foxm1b is required for its activation by cyclin-cdk1further analysis reveals that the leu-641 residue within an lxl motif is required for the recruitment of the cyclin-cdk complex, and the thr-596 residue is a critical cdk1 phosphorylation site within the a... | SIGNOR-187880 |
P02818 | P15036 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Ets2 is expressed at high levels during the differentiation and matrix mineralization phases of MC3T3-E1 culture. In addition, several extracellular matrix (ECM) associated gene products are targets of Ets2. Some of these matrix associated genes include: bone sialoprotein, osteonectin, osteocalcin and osteopontin | SIGNOR-259875 |
P23246 | P11387 | 2 | binding | up-regulates | 0.372 | We show that the psf/p54 dimer has pronounced stimulatory effect on dna catalysis by topoisomerase i | SIGNOR-60563 |
Q96GX5 | P31749 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we report that AKT phosphorylates MASTL at residue T299, which plays a critical role in its activation. | SIGNOR-277515 |
P00533 | P35222 | 1 | phosphorylation | up-regulates activity | 0.773 | EGFR and TRKA effect on WNT3a mediated Topflash induction was abolished by U0126 or expression of dominant negative LRP6-5A mutant (XREF_FIG), demonstrating that both EGFR and TRKA signal via ERK and LRP6 pathway to upregulate WNT and beta-catenin signaling.|FGFR2, FGFR3, EGFR and TRKA Phosphorylate beta-catenin at Tyr... | SIGNOR-278309 |
P28335 | P63096 | 2 | binding | up-regulates activity | 0.293 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256734 |
Q9UNH7 | P11717 | 2 | binding | down-regulates quantity | 0.364 | Here, we discovered that the binding between SNX-BARs and CI-MPR or IGF1R is mediated by the phox-homology (PX) domain of SNX5 or SNX6 and a bipartite motif, termed SNX-BAR-binding motif (SBM), in the cargoes. our studies establish that SNX-BARs function as a direct cargo-selecting module for a large set of transmembra... | SIGNOR-269443 |
Q9UJD0 | A6NNM3 | 2 | binding | down-regulates activity | 0.265 | SH3 domains of RBPs interact with RIMs. The enhancement of depolarization-induced secretion in PC12 cells by fusion proteins that suppress the associations of RBPs with RIMs and α1 suggests that RBPs may repress RIMs, either directly or through associated proteins. | SIGNOR-264374 |
Q05655 | O15162 | 1 | phosphorylation | up-regulates | 0.424 | Following the induction of apoptosis, however, phosphorylation of serine residues decreased and it increased on threonine, consistent with the predicted pkc phosphorylation site at thr-161. Transfection of cho cells with scramblase and pkc_, but not scramblase or pkc_ alone, increased scramblase activity | SIGNOR-76904 |
P18089 | P19086 | 2 | binding | up-regulates activity | 0.437 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257109 |
Q8IYW5 | Q14669 | 0 | ubiquitination | down-regulates activity | 0.465 | Here, we show that TRIP12 and UBR5, two HECT domain ubiquitin E3 ligases, control accumulation of RNF168, a rate-limiting component of a pathway that ubiquitylates histones after DNA breakage. We find that RNF168 can be saturated by increasing amounts of DSBs. Depletion of TRIP12 and UBR5 allows accumulation of RNF168 ... | SIGNOR-266783 |
Q13976 | P11831 | 1 | phosphorylation | up-regulates | 0.275 | Myotonic dystrophy protein kinase (DMPK), a muscle- and neuron-restricted kinase, enhanced SRF-mediated promoter activity of the skeletal and cardiac alpha-actin genes in C2C12 myoblasts as well as in nonmyogenic cells. | Threonine 159 in the MADS box alphaI coil was a specific phosphorylation target in vitro as well a... | SIGNOR-188185 |
P11940 | Q13064 | 0 | ubiquitination | down-regulates activity | 0.2 | MKRN3-mediated ubiquitination was found to attenuate the binding of PABPs to the poly(A) tails of mRNA|Altogether, it is thus clear that the ubiquitination of PABPC1 or PABPC4 by MKRN3 negatively regulates the formation of translation initiation complex (TIC), attenuates their binding to poly (A)-tail contained mRNAs, ... | SIGNOR-278764 |
Q01973 | P12931 | 1 | phosphorylation | up-regulates | 0.318 | Ror1 binds to and phosphorylates c-src / ror1 kinase-dependent c-src activation | SIGNOR-196751 |
Q96T88 | P48730 | 0 | phosphorylation | up-regulates | 0.245 | We further show that uhrf1 physically interacts with _-trcp1 in a manner dependent on phosphorylation of serine 108 (s108(uhrf1)) within the dsg degron. Furthermore, we demonstrate that s108(uhrf1) phosphorylation is catalyzed by casein kinase 1 delta (ck1_) and is important for the recognition of uhrf1 by scf(_-trcp). | SIGNOR-200349 |
Q9HCI7 | P04637 | 1 | ubiquitination | down-regulates activity | 0.37 | Here we describe MSL2, a novel E3 ligase for p53 that promotes ubiquitin-dependent cytoplasmic p53 localization. Unlike Mdm2 or most other p53 E3 ligases, MSL2-mediated p53 ubiquitination does not affect the stability of p53. Moreover, the MSL2-mediated effect on p53 is Mdm2-independent. Thus, our study identifies an i... | SIGNOR-271774 |
P0DTD1-PRO_0000449624 | Q9UHD2 | 2 | binding | down-regulates activity | 0.2 | We use unbiased screening to identify SARS-CoV-2 proteins that antagonize type I interferon (IFN-I) response. We found three proteins that antagonize IFN-I production via distinct mechanisms: nonstructural protein 6 (nsp6) binds TANK binding kinase 1 (TBK1) to suppress interferon regulatory factor 3 (IRF3) phosphorylat... | SIGNOR-262510 |
O15409 | Q13224 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.318 | By interacting with CASK, TBR1 regulates several ASD candidate genes, such as GRIN2B, AUTS2 and RELN—all of which are recurrently mutated in ASD. In areas of the brain with overlapping expression patterns, such as in glutamatergic layer 6 neurons, the TBR1–FOXP2 interaction may result in co-ordinated regulation of comm... | SIGNOR-266834 |
P28482 | P23469 | 0 | dephosphorylation | down-regulates activity | 0.39 | The effect of PTP epsilon on ERKs is at least in part indirect because phosphorylation of the threonine residue in the ERK activation loop is reduced in the presence of PTP epsilon. Nonetheless, PTP epsilon is present in a molecular complex with ERK, providing PTP epsilon with opportunity to act on ERK proteins also di... | SIGNOR-248448 |
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