IdA stringlengths 6 21 | IdB stringlengths 6 21 | labels int64 0 2 | mechanism stringclasses 40
values | effect stringclasses 10
values | score float64 0.1 0.99 ⌀ | sentence stringlengths 10 1.63k ⌀ | signor_id stringlengths 12 14 |
|---|---|---|---|---|---|---|---|
P63096 | P25101 | 2 | binding | up-regulates activity | 0.406 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257052 |
P50539 | P61244 | 2 | binding | up-regulates activity | 0.558 | The role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT... | SIGNOR-240314 |
Q969Q1 | P55036 | 1 | polyubiquitination | down-regulates quantity by destabilization | 0.403 | S5a/Rpn10 is a ubiquitin (Ub)-binding protein that is a subunit of the 26S proteasome but also exists free in the cytosol. It binds poly-Ub chains through its two Ub-interacting motifs (UIMs). We discovered that, unlike typical substrates of Ub ligases (E3s), S5a can be ubiquitinated by all E3s tested including multime... | SIGNOR-272741 |
Q14689 | Q12841 | 2 | binding | up-regulates activity | 0.48 | We identified DIP2A as a novel FSTL1-binding partner from the membrane fraction of endothelial cells. Co-immunoprecipitation assays revealed a direct physical interaction between FSTL1 and DIP2A. The work in the current study identifies DIP2A as a novel receptor for FSTL1 that mediates Akt activation and cell survival... | SIGNOR-266603 |
P46108 | P09619 | 2 | binding | up-regulates | 0.609 | Crk could bind to both pdgf alpha- and beta-receptors in vivo | SIGNOR-75884 |
P25105 | P63092 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-256789 |
P53367 | Q15139 | 0 | phosphorylation | up-regulates | 0.385 | We report that arfaptins contain an amphipathic helix (ah) preceding the bar domain, which is essential for their binding to phosphatidylinositol 4-phosphate (pi(4)p)-containing liposomes and the tgn of mammalian cells. The binding of arfaptin1, but not arfaptin2, to pi(4)p is regulated by protein kinase d (pkd) mediat... | SIGNOR-202101 |
O60216 | Q8N3U4 | 2 | binding | up-regulates quantity by stabilization | 0.965 | Cohesin is an evolutionarily conserved complex composed of four core proteins (SMC1A, SMC3, RAD21 and either STAG2 or STAG1) that form a ring-shaped structure able to encircle chromatin | SIGNOR-261511 |
Q06413 | P35580 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.345 | Myocyte enhancer factor-2 and serum response factor binding elements regulate fast Myosin heavy chain transcription in vivo. We show that the upstream promoter region of the gene most abundantly expressed in mouse skeletal muscles, IIb MyHC, retains binding activity and transcriptional activation for three positive tra... | SIGNOR-238769 |
O75293 | Q9UQ88 | 2 | binding | down-regulates activity | 0.2 | Western blot analysis for SPDEF revealed that overexpression of GADD45α, β and γ prevents SPDEF degradation mediated by CDK11p58 |We identified CDK11p58 as an interaction partner of GADD45α by co-immunoprecipitation analysis. We corroborated these data by co-immunoprecipitation in vitro translation assays, showing that... | SIGNOR-273024 |
P19525 | P06493 | 1 | phosphorylation | down-regulates | 0.328 | Our findings demonstrate that (i) pkr, ser/thr kinase, phosphorylates its new substrate cdc2 at the tyr 4 residue, (ii) pkr-mediated tyr 4-phosphorylation facilitates cdc2 ubiquitination and proteosomal degradation | SIGNOR-164809 |
P46934 | Q13501 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.277 | Depletion of NEDD4 dramatically reduced the LC3 protein level and elevated the SQSTM1 protein level.|Furthermore, SQSTM1 is ubiquitinated by NEDD4 while LC3 functions as an activator of NEDD4 ligase activity. | SIGNOR-278637 |
P48729 | Q2M2I3 | 2 | binding | up-regulates quantity | 0.2 | We identified members of the FAM83 family of proteins as partners of CK1 in cells. All eight members of the FAM83 family (FAM83A–H) interacted with the α and α-like isoforms of CK1; FAM83A, -B, -E, and -H also interacted with the δ and ε isoforms of CK1. The intrinsic catalytic activity of CK1 is not affected by or req... | SIGNOR-273750 |
Q16539 | P41970 | 1 | phosphorylation | up-regulates | 0.379 | Tcf sap-1a is efficiently phosphorylated by p38 map kinase in vitro and in vivo on the homologous residues ser381 and ser387. Mutation of these sites to alanine severely reduces c-fos sre-dependent transcription mediated by sap-1a and p38 map kinase. | SIGNOR-47685 |
Q86TM6 | P60484 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.2 | Secondly, HRD1 promotes PTEN ubiquitination and degradation. | SIGNOR-278724 |
O00506 | P46937 | 1 | phosphorylation | up-regulates activity | 0.265 | Collectively, our data demonstrate that loss of STK25 promotes YAP/TAZ activation.|Lastly, we assessed if STK25 is able to promote YAP phosphorylation in the absence of LATS-HM phosphorylation, based on our in vitro kinase assay results. | SIGNOR-278993 |
Q01860 | Q6U7Q0 | 0 | transcriptional regulation | up-regulates quantity by expression | 0.2 | Chromatin immunoprecipitation (ChIP) and dual-luciferase reporter assays revealed that Zfp322a binds to Pou5f1 and Nanog promoters and regulates their transcription. | SIGNOR-264900 |
P10915 | P14780 | 0 | cleavage | down-regulates quantity by destabilization | 0.341 | Matrix metalloproteinases cleave at two distinct sites on human cartilage link protein. Sequencing studies of modified link protein components revealed that stromelysins-1 and -2, gelatinases A and B and collagenase cleaved specifically between His16 and Ile17, and matrilysin, stromelysin-2 and gelatinase A cleaved bet... | SIGNOR-256328 |
P31749 | P12931 | 0 | phosphorylation | up-regulates activity | 0.677 | Regulation of Akt/PKB Activation by Tyrosine PhosphorylationAs shown in Fig. 2 d, while mutation of Tyr340 has little effect on either tyrosine phosphorylation or kinase activity of Akt induced by Src527F, substitution of Tyr315 or Tyr326 with a phenylalanine, respectively, dramatically reduces both the tyrosine phosph... | SIGNOR-252623 |
O14920 | P54646 | 0 | phosphorylation | up-regulates | 0.257 | These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and t... | SIGNOR-174405 |
O15105 | Q9Y5K5 | 2 | binding | up-regulates | 0.662 | Here, we report a novel interaction between smads and ubiquitin c-terminal hydrolase uch37, a deubiquitinating enzyme that could potentially reverse smurf-mediated ubiquitination. In gst pull down experiments, uch37 bound weakly to smad2 and smad3, and bound very strongly to smad7 in a region that is distinct from the ... | SIGNOR-138879 |
P0DPK2 | Q92830 | 0 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269597 |
Q12809 | Q15139 | 0 | phosphorylation | down-regulates activity | 0.2 | Based on LC-MS results from in vivo and HEK293 cell experiments we chose four KV11.1 mutant candidates for further functional analysis. Ablation of the putative PKD phosphorylation site in the mutant S284A increased the maximal current indicating S284 as a main PKD target in KV11.1. | SIGNOR-277612 |
P32519 | P67775 | 0 | dephosphorylation | down-regulates activity | 0.2 | Elf-1 enhances the expression of CD3zeta, whereas it suppresses the expression of FcRgamma gene and lupus T cells have decreased amounts of DNA-binding 98 kDa form of Elf-1. We show that the aberrantly increased PP2A in lupus T cells dephosphorylates Elf-1 at Thr-231. Dephosphorylation results in limited expression and... | SIGNOR-248634 |
Q9C0F0 | O60341 | 2 | binding | down-regulates activity | 0.266 | Here, we showed that ASXL3 interacts with HP1α and LSD1, leading to transcriptional repression. | SIGNOR-266764 |
O75143 | Q8TDY2 | 2 | binding | up-regulates | 0.919 | Atg13 directly binds fip200. | SIGNOR-184120 |
P35568 | Q04759 | 0 | phosphorylation | down-regulates activity | 0.567 | Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). | SIGNOR-260906 |
P21246 | Q9UM73 | 2 | binding | up-regulates | 0.547 | We conclude from this series of experiments that ptn specifically binds to the alk orphan receptor as a high affinity ligand at least in part via the putative ligand binding domain described above. | SIGNOR-106411 |
P05154 | P02751 | 2 | binding | down-regulates activity | 0.312 | SERPINA5 inhibits HCC cell migration by directly interacting with fibronectin. SERPINA5 disrupts the fibronectin–integrin β1 signaling pathway. | SIGNOR-265881 |
P12931 | P35916 | 1 | phosphorylation | up-regulates | 0.513 | Vegfr-3 is a direct c-src target and mass spectrometry analysis identified the sites phosphorylated by c-src as tyrosine 830, 833, 853, 1063, 1333, and 1337 vegfr-3 phosphorylation activates the recruitment to the receptor of the adaptor proteins crki/ii and shc inducing activation of jnk. | SIGNOR-165035 |
P49336 | P84022 | 1 | phosphorylation | down-regulates | 0.566 | Similarly, tgf-?-Induced and cdk8/9-mediated phosphorylation of smad3 at threonine 179 (t179) is important for binding of the nedd4l e3 ubiquitin ligase, which accelerates smad3 turnover;cdk8 and cyclint-cdk9 showed a preference for s206 and s214 but also phosphorylated s186 and s195 in the case of smad1;and t179, s208... | SIGNOR-161557 |
Q15418 | P28482 | 0 | phosphorylation | up-regulates activity | 0.759 | Several lines of evidence indicate that the mapkap-k1 isoforms are also activated by mapks in vivo via the ras-dependent protein kinase cascade that is triggered by growth factors or tumor-promoting phorbol esters, such as phorbol 12-myristate 13-acetate (pma). here we identify six sites in mapkap-k1a that become phosp... | SIGNOR-219308 |
P30307 | P06493 | 2 | dephosphorylation | up-regulates | 0.858 | Cdk1/cdc2 activation involves tyr15/thr14 dephosphorylation by cdc25c | SIGNOR-186621 |
P31749 | Q9Y4P1 | 1 | phosphorylation | up-regulates activity | 0.31 | In this study, we identified a novel phosphorylation site at Ser34 of ATG4B induced by AKT in HCC cells.| In brief, our results demonstrate for the first time that the phosphorylation of ATG4B at Ser34 participates in the metabolic reprogramming of HCC cells via repressing mitochondrial function, which possibly results... | SIGNOR-275834 |
Q06413 | Q9UKV0 | 2 | binding | down-regulates | 0.633 | Mirk activated mef2 not through direct phosphorylation of mef2 but by phosphorylation of its inhibitors, the class ii histone deacetylases (hdacs). Mef2 is sequestered by class ii hdacs such as hdac5 and mef2-interacting transcriptional repressor (mitr). Mirk antagonized the inhibition of mef2c by mitr, whereas kinase-... | SIGNOR-235642 |
P02545 | Q9UH99 | 1 | relocalization | up-regulates activity | 0.622 | In the case of Sun2, there is some evidence that A-type lamins might contribute to Sun2 localization in the INM. We report that an interaction between subunits of the HOPS complex and the ERM (ezrin, radixin, moesin) proteins is required for the delivery of EGF receptor (EGFR) to lysosomes. Inhibiting either ERM protei... | SIGNOR-261310 |
Q14833 | P63092 | 2 | binding | up-regulates activity | 0.344 | MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G p... | SIGNOR-264082 |
Q96J02 | Q12778 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.258 | Mechanistically, Itch ubiquitinates Foxo1 for proteasomal degradation. | SIGNOR-278698 |
P63000 | Q8N103 | 0 | gtpase-activating protein | down-regulates activity | 0.402 | We therefore developed a screening-compatible live-cell imaging assay, using FRET-based biosensors for the prototype GTPases RHOA, RAC1 and CDC4215,19,20 (Extended Data Fig. 2 and Supplementary Note 1)|We found catalytic activities for 45/75 RhoGEFs and 48/63 RhoGAPs| Our data thus not only reveal extensive promiscuity... | SIGNOR-260524 |
Q92598 | P19784 | 0 | phosphorylation | down-regulates activity | 0.327 | Protein kinase CK2 phosphorylates Hsp105 alpha at Ser509 and modulates its function. | the phosphorylation of Hsp105 alpha at Ser(509) abolished the inhibitory activity of Hsp105 alpha in vitro. | SIGNOR-251008 |
P67775 | P23443 | 1 | dephosphorylation | down-regulates | 0.72 | Protein phosphatase 2a inactivates the mitogen-stimulated s6 kinase from swiss mouse 3t3 cells | SIGNOR-23575 |
P04637 | Q9HCI7 | 0 | ubiquitination | down-regulates activity | 0.37 | Here we describe MSL2, a novel E3 ligase for p53 that promotes ubiquitin-dependent cytoplasmic p53 localization. Unlike Mdm2 or most other p53 E3 ligases, MSL2-mediated p53 ubiquitination does not affect the stability of p53. Moreover, the MSL2-mediated effect on p53 is Mdm2-independent. Thus, our study identifies an i... | SIGNOR-271774 |
Q02156 | P11362 | 1 | phosphorylation | up-regulates | 0.2 | Phosphorylation of serine 779 in fibroblast growth factor receptor 1 and 2 by protein kinase c(epsilon) regulates ras/mitogen-activated protein kinase signaling and neuronal differentiationour findings show that in addition to fgfr tyrosine phosphorylation, the phosphorylation of a conserved serine residue, ser(779), c... | SIGNOR-201671 |
Q9NYJ8 | Q9Y4K3 | 2 | binding | up-regulates activity | 0.933 | The irak1/traf6 complex can also activate jnk and p38 signalling through assembly of a catalytically active tab2-tab3-tak1 complex. | SIGNOR-205458 |
P42261 | Q13555 | 0 | phosphorylation | up-regulates activity | 0.63 | In this study, CaM-kinase II enhanced kainate currents of expressed glutamate receptor 6 in 293 cells and of wild-type glutamate receptor 1, but not the Ser-627 to Ala mutant, in Xenopus oocytes. | This CaM-kinase II regulatory phosphorylation site is conserved in all AMPA/kainate-type glutamate receptors, and its phos... | SIGNOR-250697 |
P31314 | P06400 | 2 | binding | down-regulates activity | 0.2 | ectopic HOX11 expression resulted in hyperphosphorylation of the retinoblastoma protein (Rb), which correlated with inhibition of the major Rb serine/threonine phosphatase PP1. | SIGNOR-240725 |
Q13950 | P84022 | 2 | binding | down-regulates activity | 0.738 | Tgf-beta inhibited the expression of the cbfa1 and osteocalcin genes, whose expression is controlled by cbfa1 in osteoblast-like cell lines. This inhibition was mediated by smad3, which interacts physically with cbfa1 and represses its transcriptional activity at the cbfa1-binding ose2 promoter sequence. | SIGNOR-235902 |
Q06210 | P17252 | 0 | phosphorylation | down-regulates activity | 0.307 | Phosphorylation of human glutamine:fructose-6-phosphate amidotransferase by cAMP-dependent protein kinase at serine 205 blocks the enzyme activity. | SIGNOR-249040 |
Q6IQ49 | Q9NZJ0 | 2 | binding | down-regulates quantity by destabilization | 0.282 | Here, we identify human SDE2 as a new genome surveillance factor regulated by PCNA interaction. The cleaved SDE2 products need to be degraded by the CRL4CDT2 ubiquitin E3 ligase in a cell cycle- and DNA damage-dependent manner, and failure to degrade SDE2 impairs S phase progression and cellular survival. | SIGNOR-272807 |
Q9NY46 | Q92914 | 2 | binding | down-regulates activity | 0.2 | Sodium channel fast inactivation is modulated by alpha subunit interaction with a family of cytoplasmic proteins termed fibroblast growth factor homologous factors (FHFs). In this paper, we report that all A-type FHFs exert rapid onset long-term inactivation on Nav1.6 and other sodium channels. | SIGNOR-253446 |
P27695 | Q00987 | 0 | ubiquitination | down-regulates quantity by destabilization | 0.416 | Once the reaction proceeds beyond the monoubiquitination stage, MDM2 polyubiquitinates APE1 for degradation. | SIGNOR-278555 |
Q9UL17 | P60568 | 1 | transcriptional regulation | down-regulates quantity by repression | 0.473 | T-bet Transactivates the IFNγ Gene and Represses the IL-2 Gene in EL4 Cells | SIGNOR-266233 |
Q02962 | O75688 | 0 | dephosphorylation | down-regulates activity | 0.2 | PPM1B can dephosphorylate the Pax2 activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation | SIGNOR-251712 |
P09651 | Q9UHD9 | 2 | binding | up-regulates quantity by stabilization | 0.458 | Confirmation of binding of recombinant full-length hnRNPA1 and hnRNPU proteins with ubiquilin-2 by GST-pull-down assays|Additionally, our evidence that ubiquilin-2 is in- volved in stabilizing hnRNPA1 protein | SIGNOR-262270 |
Q9UNE7 | Q16665 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.376 | the ubiquitin ligase activity of CHIP regulates HIF-1α degradation. | SIGNOR-271426 |
O96017 | Q9NQS7 | 1 | phosphorylation | up-regulates activity | 0.261 | Also, inhibition of Chk2 by Chk2 inhibitor II in cytokinesis after release of cells from a nocodazole-induced prometaphase block diminished INCENP localization to the midbody center in late midbodies (Fig. 1, M and N).|In turn, active Chk2 phosphorylates human INCENP at the newly identified site Ser91 to promote INCENP... | SIGNOR-279695 |
P61244 | Q9Y6D9 | 2 | binding | up-regulates activity | 0.301 | the role MAX plays in transcription is thought to be primarily as a cofactor for DNA binding. In this capacity, however, it appears to be essential for most, if not all, the known biological activities of MYC. MAX also functions as a cofactor for DNA binding for a group of bHLHZip proteins related to MYC, including MNT... | SIGNOR-240357 |
P68366 | Q14980 | 2 | binding | up-regulates | 0.514 | Direct binding of numa to tubulin is mediated by a novel sequence motif in the tail domain that bundles and stabilizes microtubules. | SIGNOR-116788 |
Q7Z6J0 | Q9UQF2 | 2 | binding | up-regulates | 0.283 | We find that posh and jips directly associate with one another to form a multiprotein complex, pjac (posh-jip apoptotic complex), that includes all of the known kinase components of the pathway. Our observations indicate that this complex is required for jnk activation and cell death in response to apoptotic stimuli. | SIGNOR-145393 |
P06493 | P22674 | 2 | binding | up-regulates activity | 0.335 | CDK2 is the predominant activating complex form of CCNO, but CCNO can bind to CDK1 to form an activating complex in the absence of CDK2. | SIGNOR-275617 |
P29317 | P52803 | 2 | binding | up-regulates | 0.922 | Members of the epha subfamily of receptor tyrosine kinases and their ephrin-a ligands have been implicated in the guidance of retinal axons along the anterior-posterior axis of the chick optic tectum. | SIGNOR-52467 |
Q01105-2 | P68400 | 0 | phosphorylation | down-regulates | 0.365 | Ckii-mediated phosphorylation at ser9 hinders nuclear import of set | SIGNOR-200798 |
P09471 | Q99677 | 2 | binding | up-regulates activity | 0.2 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257258 |
P98170 | O95831 | 1 | ubiquitination | down-regulates quantity by destabilization | 0.434 | Notably, cotransfection of XIAP along with AIF resulted in the complete inhibition of DNA degradation (21.2% degraded nuclei), suggesting that XIAP directly abrogates the ability of AIF to induce chromatin degradation.|XIAP binds and ubiquitinates AIF, and in this study, we determined the functional consequences of XIA... | SIGNOR-278537 |
Q12968 | Q08209 | 0 | dephosphorylation | up-regulates | 0.538 | Calcineurin directly dephosphorylates nfat resulting in the nuclear import of nfat. | SIGNOR-176376 |
Q99767 | P61764 | 2 | binding | up-regulates activity | 0.701 | Munc18-1 is a neuronal protein that interacts with syntaxin 1 and is required for synaptic vesicle exocytosis. We have now identified two Munc18-1-interacting proteins called Mint1 and Mint2 that may mediate the function of Munc18-1. | SIGNOR-264037 |
Q7Z570 | P58166 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.2 | ZNF804A has been implicated in susceptibility to schizophrenia by several genome-wide association studies (GWAS), follow-up association studies and meta-analyses. ZNF804A was identified as a schizophrenia-associated gene by GWAS and was predicted to play a role in DNA binding and transcription To identify the genes th... | SIGNOR-269462 |
P37231 | P36507 | 2 | binding | up-regulates | 0.2 | The genomic activity of ppargamma is modulated, in addition to ligand binding, by phosphorylation of a serine residue by mapks, such as extracellular signal-regulated protein kinases-1/2 (erk-1/2), or by nucleocytoplasmic compartmentalization through the erk activators mapk kinases-1/2 (mek-1/2). These mapks phosphoryl... | SIGNOR-179393 |
P19086 | P32249 | 2 | binding | up-regulates activity | 0.249 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257110 |
P43489 | P23510 | 2 | binding | up-regulates | 0.921 | Activation of nf-kappab in ox40-transfected hsb-2 cells was detected by electrophoretic mobility shift assay within 30 min after the binding of the ligand gp34. | SIGNOR-54927 |
Q13177 | P35240 | 1 | phosphorylation | down-regulates | 0.512 | Merlin contains a c-terminal serine 518, which is phosphorylated both by p21-activated kinase (pak) and protein kinase a (pka) (shaw et al., 2001;kissil et al., 2002;xiao et al., 2002;alfthan et al., 2004). Phosphorylation at this site is predicted to result in a more open conformation incapable of inhibiting cell grow... | SIGNOR-159768 |
P46527 | Q06124 | 0 | dephosphorylation | up-regulates activity | 0.281 | Moreover, SHP-2 was strongly activated on G-CSF stimulation and specifically dephosphorylated p27(Kip1) in vitro.|Most importantly, we could illustrate that SHP-2 modulates p27 (Kip1) stability and contributes to p27 (Kip1)-mediated cell cycle progression. | SIGNOR-277168 |
Q96J02 | Q86Y01 | 1 | ubiquitination | down-regulates | 0.7 | Itch/aip4 mediates deltex degradation through the formation of k29-linked polyubiquitin chains. | SIGNOR-150002 |
Q16531 | Q01094 | 2 | binding | up-regulates | 0.351 | We show that ddb, a putative dna repair protein, associates with the activation domain of e2f1 / expression of ddb specifically stimulated e2f1-activated transcription | SIGNOR-54096 |
Q96KS0 | P30566 | 1 | hydroxylation | up-regulates activity | 0.2 | ADSL is hydroxylated by EglN2 on Proline 24. An integrated transcriptomics and metabolomics analysis reveals that ADSL activates the oncogenic cMYC pathway by regulating cMYC protein level via a mechanism requiring ADSL proline 24 hydroxylation. ADSL regulates cMYC protein level through adenosine levels | SIGNOR-266613 |
P04150 | P07900 | 2 | binding | down-regulates | 0.735 | We report the crucial underlying role of the intranuclear heat shock protein 90 molecular chaperone complex in pulsatile GR regulation. Pharmacological interference of heat shock protein 90 (HSP90) with geldanamycin during the intranuclear chaperone cycle completely ablated GR's cyclical activity, cyclical cAMP respons... | SIGNOR-251667 |
Q13153 | Q70Z35 | 1 | phosphorylation | down-regulates activity | 0.367 | P21-activated Kinases (PAKs) Mediate the Phosphorylation of PREX2 Protein to Initiate Feedback Inhibition of Rac1 GTPase. PAK-mediated phosphorylation of PREX2 reduced GEF activity toward Rac1 by inhibiting PREX2 binding to PIP3 and Gβγ. | SIGNOR-277181 |
Q00535 | O14936 | 1 | phosphorylation | up-regulates activity | 0.288 | Cdk5 promotes synaptogenesis by regulating the subcellular distribution of the MAGUK family member CASK.|We found that Cdk5 phosphorylates and regulates CASK distribution to membranes. | SIGNOR-280216 |
Q99720 | Q9NZQ7 | 1 | stabilization | up-regulates quantity by stabilization | 0.2 | We propose that Sigma1 is a ligand-operated scaffolding protein that promotes the stability, processing, assembly, and trafficking of specific proteins in the secretory pathway of cancer cells. In support of this hypothesis, we found that siRNA-mediated knockdown of Sigma1 resulted in a significant decrease in PD-L1 pr... | SIGNOR-274974 |
O95433 | P07900 | 2 | binding | up-regulates activity | 0.742 | The N-terminal region of Aha1 interacts with the central domain of Hsp90 and stimulates Hsp90 ATPase activity | SIGNOR-252211 |
P08238 | P31948 | 2 | binding | down-regulates activity | 0.855 | Hsp90 chaperone cycle is tightly regulated by another group of proteins referred to as ‘co-chaperones'. Their stability does not depend on Hsp90 function but they interact with distinct Hsp90 conformational states, providing directionality to the Hsp90 cycle4. Furthermore, certain co-chaperones, such as HOP and Cdc37p5... | SIGNOR-261412 |
Q96NY9 | P68400 | 0 | phosphorylation | up-regulates activity | 0.2 | Here, we show that the CK2 kinase phosphorylates MUS81 at Serine 87 in late-G2/mitosis, and upon mild replication stress. Phosphorylated MUS81 interacts with SLX4, and this association promotes the function of the MUS81 complex. | SIGNOR-273626 |
Q8IXJ9 | P42772 | 1 | transcriptional regulation | up-regulates quantity by expression | 0.276 | Tumor suppressor ASXL1 is essential for the activation of INK4B expression in response to oncogene activity and anti-proliferative signals | SIGNOR-241759 |
Q92915 | P67870 | 0 | phosphorylation | up-regulates activity | 0.27 | Bioluminescence-based screening of small molecule modulators of the FGF14:Nav1.6 complex identified 4,5,6,7 -: tetrabromobenzotriazole (TBB), a potent casein kinase 2 (CK2) inhibitor, as a strong suppressor of FGF14:Nav1.6 interaction. Inhibition of CK2 through TBB reduces the interaction of FGF14 with Nav1.6 and Nav1.... | SIGNOR-275745 |
P30556 | P50148 | 2 | binding | up-regulates activity | 0.643 | Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signali... | SIGNOR-257017 |
P10912 | O60674 | 0 | phosphorylation | up-regulates activity | 0.766 | Jak2 is then phosphorylated and, in turn, phosphorylates the GHR and the signal transducers and activators of transcription (STAT) protein. | SIGNOR-279198 |
O43292 | Q96S52 | 2 | binding | up-regulates activity | 0.895 | To determine roles for PIG-S and PIG-T, we disrupted these genes in mouse F9 cells by homologous recombination. PIG-S and PIG-T knockout cells were defective in transfer of GPI to proteins, particularly in formation of the carbonyl intermediates. We also demonstrate that PIG-S and PIG-T form a protein complex with GAA1... | SIGNOR-261361 |
Q15831 | P06241 | 0 | phosphorylation | down-regulates activity | 0.327 | Moreover, Fyn kinase directly phosphorylated LKB1 on tyrosine 261 and 365 residues and mutations of these sites resulted in LKB1 export into the cytoplasm and increased AMPK phosphorylation. | SIGNOR-278477 |
Q96QT4 | P16885 | 1 | phosphorylation | up-regulates activity | 0.263 | We present data indicating that TRPM7 phosphorylates phospholipase C\u03b32 at position Ser1164 in the C2-domain, and at position Thr1045 in the linker between the catalytic region and the C2 domain. | SIGNOR-278460 |
P06493 | Q8TD19 | 1 | phosphorylation | up-regulates activity | 0.482 | We now identify Plk1 as Nek9 direct activator and propose a two-step activation mechanism that involves Nek9 sequential phosphorylation by CDK1 and Plk1. while CDK1 activity is necessary for Nek9 phosphorylation in mitosis and the resulting change in electrophoretical mobility, Nek9 Thr210 phosphorylation and mitotic a... | SIGNOR-273889 |
Q14686 | P28482 | 0 | phosphorylation | up-regulates activity | 0.2 | In vitro phosphorylation studies with His-tagged TRBP (795–931) suggested that S884 can be phosphorylated by MAPK (ERK2) in vitro (Fig. 10A).Analysis of in vitro and in vivo receptor interactions with TRBP suggested that S884 allowed selective interactions for ERβ, TR, and RXR vs. ERα. | SIGNOR-265882 |
Q07955 | P51955 | 0 | phosphorylation | down-regulates activity | 0.385 | First, NEK2 interacts with and phosphorylates SRSF1. | SIGNOR-279344 |
Q14232 | P49841 | 2 | binding | down-regulates | 0.2 | Akt also promotes protein synthesis by phosphorylating and inactivating gsk3b, thus releasing the gsk3b-dependent inhibition of the eukariotic translation initiation factor 2b (eif2b). | SIGNOR-175436 |
Q92830 | Q5TEC6 | 1 | acetylation | down-regulates activity | 0.2 | The HAT module within the SAGA and ADA complexes acetylates histone H3, mainly on residues K9 and K14. | SIGNOR-269599 |
Q08211 | P35637 | 0 | relocalization | down-regulates activity | 0.482 | We found that ALS mutants of FUS co-localized with Caprin-1, DDX3X, and DHX9 in cytoplasmic inclusions that could lead to the mis-regulation of their respective pathways, providing further clues to the mechanism of ALS pathogenesis.|FUS interacting proteins were sequestered into the cytoplasmic mutant FUS inclusions th... | SIGNOR-262810 |
P31645 | Q9UHD2 | 0 | phosphorylation | up-regulates activity | 0.2 | Taken together, our data suggest that TBK1 expression promotes the general cellular clearance mechanism of soluble HTT and prevents its accumulation and aggregation by enhancing autophagy.|This confirmed that TBK1 phosphorylated endogenous HTT at S13 (Fig XREF_FIG G and H). | SIGNOR-278384 |
Q99527 | P59768 | 2 | binding | up-regulates activity | 0.385 | GPCRs transduce their signal via G-protein heterotrimers (αβγ) that dissociate in free Gα-subunit protein and Gβγ-subunit protein complexes following ligand stimulation; GNG2 stands for the subunit γ, which dissociates from the receptor after the binding of GTP on α-subunit. | SIGNOR-251104 |
Q13153 | O15344 | 1 | phosphorylation | up-regulates activity | 0.2 | Pak1 phosphorylates the N-terminus of Mid1 to promote its association with cortical nodes.|Pak1 promotes Mid1 localization to cortical nodes. | SIGNOR-279307 |
Q8IZF0 | Q8N2C7 | 2 | binding | up-regulates activity | 0.809 | The NALCN complex in the brain consists of NALCN, UNC80 and UNC79. UNC80 directly associates with NALCN and UNC79 forms part of the complex by its interaction with UNC80. | SIGNOR-265184 |
P14384 | P69905 | 1 | cleavage | down-regulates activity | 0.2 | Both human plasma carboxypeptidase N (CPN) and membrane-bound carboxypeptidase M (CPM) released the C-terminal arginine (alpha-Arg141) of the alpha chain of human adult hemoglobin. Thus, the hydrolysis of hemoglobin by CPM and CPN demonstrated the contribution of the alpha-Arg141 residue to sustaining the tetrameric st... | SIGNOR-256507 |
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